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Conserved domains on  [gi|1046889252|ref|XP_017449058|]
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leucine-rich repeat-containing protein 69 isoform X1 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-240 6.41e-33

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 126.59  E-value: 6.41e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  15 TALKGGKSTKILTLNGKKMSKMPSALEKLPNLRTLDLQNNQISkvcpelrtltkltllnlgnnllqEVPEEIKYLTSLKN 94
Cdd:COG4886   107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLT-----------------------DLPEPLGNLTNLKS 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  95 LhlfgnricriaagvldglgdlvllNLNDNQLSSLPPEIGRLQNLTFLSLNHNKLTVIPKEICFLEHLSELHINYNRITR 174
Cdd:COG4886   164 L------------------------DLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTD 219

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046889252 175 IPEEIRFLQNLQQLSLVRNNIEELPeEVCQLTKLGVLDVAGNVIQIFPAGFQDLKLREFYCEGNPL 240
Cdd:COG4886   220 LPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-240 6.41e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 126.59  E-value: 6.41e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  15 TALKGGKSTKILTLNGKKMSKMPSALEKLPNLRTLDLQNNQISkvcpelrtltkltllnlgnnllqEVPEEIKYLTSLKN 94
Cdd:COG4886   107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLT-----------------------DLPEPLGNLTNLKS 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  95 LhlfgnricriaagvldglgdlvllNLNDNQLSSLPPEIGRLQNLTFLSLNHNKLTVIPKEICFLEHLSELHINYNRITR 174
Cdd:COG4886   164 L------------------------DLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTD 219

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046889252 175 IPEEIRFLQNLQQLSLVRNNIEELPeEVCQLTKLGVLDVAGNVIQIFPAGFQDLKLREFYCEGNPL 240
Cdd:COG4886   220 LPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 26-260 1.65e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 68.72  E-value: 1.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  26 LTLNGKKMS-KMPSALEKLPNLRTLDLQNNQISKvcpelrtltkltllnlgnnllqEVPEEIKYLT-SLKNLHLFGNRIC 103
Cdd:PLN00113   74 IDLSGKNISgKISSAIFRLPYIQTINLSNNQLSG----------------------PIPDDIFTTSsSLRYLNLSNNNFT 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252 104 riAAGVLDGLGDLVLLNLNDNQLS-SLPPEIGRLQNLTFLSLNHNKLT-VIPKEICFLEHLSELHINYNRIT-RIPEEIR 180
Cdd:PLN00113  132 --GSIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELG 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252 181 FLQNLQQLSLVRNNIE-ELPEEVCQLTKLGVLD-VAGNVIQIFPAGFQDLKLREFycegnpLFL-KNPIFAPQPKDLWTL 257
Cdd:PLN00113  210 QMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDlVYNNLTGPIPSSLGNLKNLQY------LFLyQNKLSGPIPPSIFSL 283


                  ...
gi 1046889252 258 REI 260
Cdd:PLN00113  284 QKL 286
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 14-216 8.83e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.96  E-value: 8.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  14 LTALKGGKSTKILTLNGKKMSKMPSaLEKLPNLRTLDLQNNQISKVcpelrtltkltllnlgnnllqevpEEIKYLTSLK 93
Cdd:cd21340    17 IDNLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKI------------------------ENLENLVNLK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  94 NLHLFGNRICRIAagvldglgdlvllNLNdnqlsslppeigRLQNLTFLSLNHNKLtviPKEICFL----------EHLS 163
Cdd:cd21340    72 KLYLGGNRISVVE-------------GLE------------NLTNLEELHIENQRL---PPGEKLTfdprslaalsNSLR 123

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046889252 164 ELHINYNRITRIpEEIRFLQNLQQLSLVRNNIEELpEEVCQL----TKLGVLDVAGN 216
Cdd:cd21340   124 VLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDL-EELLDLlsswPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
137-195 1.01e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.01e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046889252 137 QNLTFLSLNHNKLTVIPKEiCF--LEHLSELHINYNRITRI-PEEIRFLQNLQQLSLVRNNI 195
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDG-AFkgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-240 6.41e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 126.59  E-value: 6.41e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  15 TALKGGKSTKILTLNGKKMSKMPSALEKLPNLRTLDLQNNQISkvcpelrtltkltllnlgnnllqEVPEEIKYLTSLKN 94
Cdd:COG4886   107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLT-----------------------DLPEPLGNLTNLKS 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  95 LhlfgnricriaagvldglgdlvllNLNDNQLSSLPPEIGRLQNLTFLSLNHNKLTVIPKEICFLEHLSELHINYNRITR 174
Cdd:COG4886   164 L------------------------DLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTD 219

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046889252 175 IPEEIRFLQNLQQLSLVRNNIEELPeEVCQLTKLGVLDVAGNVIQIFPAGFQDLKLREFYCEGNPL 240
Cdd:COG4886   220 LPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-240 1.56e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 114.65  E-value: 1.56e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  37 PSALEKLPNLRTLDLQNNQISkvcpelrtltkltllnlgnnllqEVPEEIKYLTSLKNLhlfgnricriaagvldglgdl 116
Cdd:COG4886   106 NEELSNLTNLESLDLSGNQLT-----------------------DLPEELANLTNLKEL--------------------- 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252 117 vllNLNDNQLSSLPPEIGRLQNLTFLSLNHNKLTVIPKEICFLEHLSELHINYNRITRIPEEIRFLQNLQQLSLVRNNIE 196
Cdd:COG4886   142 ---DLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1046889252 197 ELPEEVCQLTKLGVLDVAGNVIQIFPAGFQDLKLREFYCEGNPL 240
Cdd:COG4886   219 DLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
21-240 1.64e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 114.65  E-value: 1.64e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  21 KSTKILTLNGKKMSKMPSALEKLPNLRTLDLQNNQISKVCPELRTLTKLTLLNLGNNLLQEVPEEIKYLTSLKNLHLFGN 100
Cdd:COG4886    27 LLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252 101 RicriaagVLDGLGDLVLLNLNDNQLSSLPPEIGRLQNLTFLSLNHNKLTVIPKEICFLEHLSELHINYNRITRIPEEIR 180
Cdd:COG4886   107 E-------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELG 179

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046889252 181 FLQNLQQLSLVRNNIEELPEEVCQLTKLGVLDVAGNVIQIFPAGFQDLK-LREFYCEGNPL 240
Cdd:COG4886   180 NLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTnLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-240 4.66e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.68  E-value: 4.66e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  43 LPNLRTLDLQNNQISKVCPELRTLTKLTLLNLGNNLLQEVPEEIKYLTSLKNLHLFGNRICRIAAGVLDGLGDLVLLNLN 122
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252 123 DNQLSSLPPEIGRLQNLTF-----------------LSLNHNKLTVIPKEICFLEHLSELHINYNRITRIPEEIRFLQNL 185
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTEldlsgneelsnltnlesLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNL 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1046889252 186 QQLSLVRNNIEELPEEVCQLTKLGVLDVAGNVIQIFPAGFQDLK-LREFYCEGNPL 240
Cdd:COG4886   162 KSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTnLEELDLSGNQL 217
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 26-260 1.65e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 68.72  E-value: 1.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  26 LTLNGKKMS-KMPSALEKLPNLRTLDLQNNQISKvcpelrtltkltllnlgnnllqEVPEEIKYLT-SLKNLHLFGNRIC 103
Cdd:PLN00113   74 IDLSGKNISgKISSAIFRLPYIQTINLSNNQLSG----------------------PIPDDIFTTSsSLRYLNLSNNNFT 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252 104 riAAGVLDGLGDLVLLNLNDNQLS-SLPPEIGRLQNLTFLSLNHNKLT-VIPKEICFLEHLSELHINYNRIT-RIPEEIR 180
Cdd:PLN00113  132 --GSIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELG 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252 181 FLQNLQQLSLVRNNIE-ELPEEVCQLTKLGVLD-VAGNVIQIFPAGFQDLKLREFycegnpLFL-KNPIFAPQPKDLWTL 257
Cdd:PLN00113  210 QMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDlVYNNLTGPIPSSLGNLKNLQY------LFLyQNKLSGPIPPSIFSL 283


                  ...
gi 1046889252 258 REI 260
Cdd:PLN00113  284 QKL 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
16-257 2.13e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 2.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  16 ALKGGKSTKILTLNGKKMSKMPSALEKLPNLRTLDLQNNQISkvcpelrtltkltllnlgnnllqEVPEEIKYLTSLKNL 95
Cdd:COG4886   177 ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT-----------------------DLPEPLANLTNLETL 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  96 HLFGNRICRIAAGVLDGLGDLVllNLNDNQLSSLPPEiGRLQNLTFLSLNHNKLTVIPKEICFLEHLSELHINYNRITRI 175
Cdd:COG4886   234 DLSNNQLTDLPELGNLTNLEEL--DLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252 176 PEEIRFLQNLQQLSLVRNNIEELPEEVCQLTKLGVLDVAGNVIQIFPAGFQDLKLREFYCEGNPLFLKNPIFAPQPKDLW 255
Cdd:COG4886   311 LELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390


                  ..
gi 1046889252 256 TL 257
Cdd:COG4886   391 LL 392
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 22-216 7.70e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 63.33  E-value: 7.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  22 STKILTLNGKK-MSKMPSALEKLPNLRTLDLQNNQISKVCPELRTLTKLTLLNLG--NNLLQEVPEEIKYLTSLKNLHLF 98
Cdd:PLN00113  165 SLKVLDLGGNVlVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLgyNNLSGEIPYEIGGLTSLNHLDLV 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  99 GNricriaagvldglgdlvllnlndNQLSSLPPEIGRLQNLTFLSLNHNKLT-VIPKEICFLEHLSELHINYNRIT-RIP 176
Cdd:PLN00113  245 YN-----------------------NLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIP 301

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1046889252 177 EEIRFLQNLQQLSLVRNNIE-ELPEEVCQLTKLGVLDVAGN 216
Cdd:PLN00113  302 ELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSN 342
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 14-216 8.83e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.96  E-value: 8.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  14 LTALKGGKSTKILTLNGKKMSKMPSaLEKLPNLRTLDLQNNQISKVcpelrtltkltllnlgnnllqevpEEIKYLTSLK 93
Cdd:cd21340    17 IDNLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKI------------------------ENLENLVNLK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  94 NLHLFGNRICRIAagvldglgdlvllNLNdnqlsslppeigRLQNLTFLSLNHNKLtviPKEICFL----------EHLS 163
Cdd:cd21340    72 KLYLGGNRISVVE-------------GLE------------NLTNLEELHIENQRL---PPGEKLTfdprslaalsNSLR 123

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046889252 164 ELHINYNRITRIpEEIRFLQNLQQLSLVRNNIEELpEEVCQL----TKLGVLDVAGN 216
Cdd:cd21340   124 VLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDL-EELLDLlsswPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 36-219 3.29e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 3.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  36 MPSALEKLPNLRTLDLQNNQISKvcpelrtltkltllnlgnnllqEVPEEIKYLTSLKNLHLFGNRICRIAAGVLDGLGD 115
Cdd:PLN00113  276 IPPSIFSLQKLISLDLSDNSLSG----------------------EIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPR 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252 116 LVLLNLNDNQLS-SLPPEIGRLQNLTFLSLNHNKLT-VIPKEICFLEHLSELHINYNRI-TRIPEEIRFLQNLQQLSLVR 192
Cdd:PLN00113  334 LQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLeGEIPKSLGACRSLRRVRLQD 413

                         170       180
                  ....*....|....*....|....*...
gi 1046889252 193 NNIE-ELPEEVCQLTKLGVLDVAGNVIQ 219
Cdd:PLN00113  414 NSFSgELPSEFTKLPLVYFLDISNNNLQ 441
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
126-227 5.42e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.24  E-value: 5.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252 126 LSSLPPEIGrlQNLTFLSLNHNKLTVIPKEIcfLEHLSELHINYNRITRIPEEIRflQNLQQLSLVRNNIEELPEEVCql 205
Cdd:PRK15370  190 LTTIPACIP--EQITTLILDNNELKSLPENL--QGNIKTLYANSNQLTSIPATLP--DTIQEMELSINRITELPERLP-- 261

                          90       100
                  ....*....|....*....|..
gi 1046889252 206 TKLGVLDVAGNVIQIFPAGFQD 227
Cdd:PRK15370  262 SALQSLDLFHNKISCLPENLPE 283
LRR_8 pfam13855
Leucine rich repeat;
137-195 1.01e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.01e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046889252 137 QNLTFLSLNHNKLTVIPKEiCF--LEHLSELHINYNRITRI-PEEIRFLQNLQQLSLVRNNI 195
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDG-AFkgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
121-223 8.78e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.77  E-value: 8.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252 121 LNDNQLSSLPPEIGrlQNLTFLSLNHNKLTVIPKEICflEHLSELHINYNRITRIPEEI-RFLQNL-------------- 185
Cdd:PRK15370  206 LDNNELKSLPENLQ--GNIKTLYANSNQLTSIPATLP--DTIQEMELSINRITELPERLpSALQSLdlfhnkisclpenl 281

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1046889252 186 ----QQLSLVRNNIEELPEEVCqlTKLGVLDVAGNVIQIFPA 223
Cdd:PRK15370  282 peelRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPE 321
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 136-236 1.31e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252 136 LQNLTFLSLNHNKLTVIPkEICFLEHLSELHINYNRITRIpEEIRFLQNLQQLSLVRNNIEELpEEVCQLTKLGVLDVAG 215
Cdd:cd21340     1 LKRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGG 77

                          90       100
                  ....*....|....*....|..
gi 1046889252 216 NVIQIFpAGFQDLK-LREFYCE 236
Cdd:cd21340    78 NRISVV-EGLENLTnLEELHIE 98
LRR_8 pfam13855
Leucine rich repeat;
120-172 1.38e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 1.38e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1046889252 120 NLNDNQLSSLPPEI-GRLQNLTFLSLNHNKLTVI-PKEICFLEHLSELHINYNRI 172
Cdd:pfam13855   7 DLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
161-218 8.74e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 8.74e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252 161 HLSELHINYNRITRIPEEI-RFLQNLQQLSLVRNNIEELPEEVCQ-LTKLGVLDVAGNVI 218
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 4-216 2.63e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252   4 SSKIMTERLLLTALKGGKSTKILTLNGKKMSKMPSALEKLPNLRTLDLQNNQISKvcpelrtltkltllnlgnnllqEVP 83
Cdd:PLN00113  364 STNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSG----------------------ELP 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  84 EEIKYLTSLKNLHLFGNRICRIAAGVLDGLGDLVLLNLNDNQLSSLPPEIGRLQNLTFLSLNHNKLT-VIPKEICFLEHL 162
Cdd:PLN00113  422 SEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSEL 501

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1046889252 163 SELHINYNRIT-RIPEEIRFLQNLQQLSLVRNNIE-ELPEEVCQLTKLGVLDVAGN 216
Cdd:PLN00113  502 MQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQN 557
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
123-216 3.23e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.46  E-value: 3.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252 123 DNQLSSLPPEIGRLQNLTFLSLNHNKLTVIPKEicflehLSELHINYNRITRIPeeiRFLQNLQQLSLVRNNIEELPEEV 202
Cdd:PRK15387  371 NNRLTSLPALPSGLKELIVSGNRLTSLPVLPSE------LKELMVSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESL 441

                          90
                  ....*....|....
gi 1046889252 203 CQLTKLGVLDVAGN 216
Cdd:PRK15387  442 IHLSSETTVNLEGN 455
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 35-193 1.71e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252  35 KMPSALEKLPNLRTLDLQNNQISKVCPELR--TLTKLTLLNLGNNLLQEVPEEIKYlTSLKNLHLFGNRICRIAAGVLDG 112
Cdd:PLN00113  419 ELPSEFTKLPLVYFLDISNNNLQGRINSRKwdMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGS 497

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252 113 LGDLVLLNLNDNQLSS-LPPEIGRLQNLTFLSLNHNKLT-VIPKEICFLEHLSELHINYNRIT-RIPEEIRFLQNLQQLS 189
Cdd:PLN00113  498 LSELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVN 577


                  ....
gi 1046889252 190 LVRN 193
Cdd:PLN00113  578 ISHN 581
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
124-254 3.77e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 39.38  E-value: 3.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252 124 NQLSSLPPEIGRLQNLTFLSLNHNKLTVIPKEICflehlsELHINYNRITRIPEeirFLQNLQQLSLVRNNIEELPEEVC 203
Cdd:PRK15387  292 NQLTSLPVLPPGLQELSVSDNQLASLPALPSELC------KLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLPTLPS 362

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1046889252 204 QLTKLGVLDVAGNVIQIFPAGfqdlkLREFYCEGNPLfLKNPIFAPQPKDL 254
Cdd:PRK15387  363 ELYKLWAYNNRLTSLPALPSG-----LKELIVSGNRL-TSLPVLPSELKEL 407
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
121-232 6.57e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 38.60  E-value: 6.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252 121 LNDNQLSSLPPEIGRLQNLTFLSLNHNKLTVIPKEICflehlsELHINYNRITRIPEeirFLQNLQQLSLVRNNIEELPE 200
Cdd:PRK15387  249 VSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLC------KLWIFGNQLTSLPV---LPPGLQELSVSDNQLASLPA 319

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1046889252 201 EVCQLTKLGVLDVAGNVIQIFPAGFQDLKLRE 232
Cdd:PRK15387  320 LPSELCKLWAYNNQLTSLPTLPSGLQELSVSD 351
LRR_9 pfam14580
Leucine-rich repeat;
158-232 9.17e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 36.67  E-value: 9.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046889252 158 FLEHLSELHINYNRITRIPEEI-RFLQNLQQLSLVRNNIEELPE-----EVCQLTKLGVLD------------VAGNVIQ 219
Cdd:pfam14580  62 LLRRLKTLLLNNNRICRIGEGLgEALPNLTELILTNNNLQELGDldplaSLKKLTFLSLLRnpvtnkphyrlyVIYKVPQ 141

                          90
                  ....*....|...
gi 1046889252 220 IFPAGFQDLKLRE 232
Cdd:pfam14580 142 LRLLDFRKVKQKE 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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