NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1059210842|ref|XP_017752427|]
View 

PREDICTED: synergin gamma-like [Eufriesea mexicana]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 502)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
EFh super family cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
50-92 2.34e-07

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


The actual alignment was detected with superfamily member cd00052:

Pssm-ID: 415501 [Multi-domain]  Cd Length: 67  Bit Score: 48.37  E-value: 2.34e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1059210842  50 LVDTNKVFPLLLTSQLPTEVLGHIWNLANQKYAGQLTEQELYI 92
Cdd:cd00052    15 LISGDEARPFLGKSGLPRSVLAQIWDLADTDKDGKLDKEEFAI 57
 
Name Accession Description Interval E-value
EH cd00052
Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and ...
50-92 2.34e-07

Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A hydrophobic binding pocket is formed by residues from both EF-hand motifs. The EH domain binds to proteins containing NPF (class I), [WF]W or SWG (class II), or H[TS]F (class III) sequence motifs.


Pssm-ID: 238009 [Multi-domain]  Cd Length: 67  Bit Score: 48.37  E-value: 2.34e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1059210842  50 LVDTNKVFPLLLTSQLPTEVLGHIWNLANQKYAGQLTEQELYI 92
Cdd:cd00052    15 LISGDEARPFLGKSGLPRSVLAQIWDLADTDKDGKLDKEEFAI 57
EH smart00027
Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe ...
50-92 3.10e-06

Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe (NPF) sequences.


Pssm-ID: 197477 [Multi-domain]  Cd Length: 96  Bit Score: 46.12  E-value: 3.10e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1059210842   50 LVDTNKVFPLLLTSQLPTEVLGHIWNLANQKYAGQLTEQELYI 92
Cdd:smart00027  26 TVTGAQAKPILLKSGLPQTLLAKIWNLADIDNDGELDKDEFAL 68
 
Name Accession Description Interval E-value
EH cd00052
Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and ...
50-92 2.34e-07

Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A hydrophobic binding pocket is formed by residues from both EF-hand motifs. The EH domain binds to proteins containing NPF (class I), [WF]W or SWG (class II), or H[TS]F (class III) sequence motifs.


Pssm-ID: 238009 [Multi-domain]  Cd Length: 67  Bit Score: 48.37  E-value: 2.34e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1059210842  50 LVDTNKVFPLLLTSQLPTEVLGHIWNLANQKYAGQLTEQELYI 92
Cdd:cd00052    15 LISGDEARPFLGKSGLPRSVLAQIWDLADTDKDGKLDKEEFAI 57
EH smart00027
Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe ...
50-92 3.10e-06

Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe (NPF) sequences.


Pssm-ID: 197477 [Multi-domain]  Cd Length: 96  Bit Score: 46.12  E-value: 3.10e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1059210842   50 LVDTNKVFPLLLTSQLPTEVLGHIWNLANQKYAGQLTEQELYI 92
Cdd:smart00027  26 TVTGAQAKPILLKSGLPQTLLAKIWNLADIDNDGELDKDEFAL 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH