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Conserved domains on  [gi|1952685561|ref|XP_038302217|]
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protein lifeguard 1 isoform X2 [Canis lupus familiaris]

Protein Classification

protein lifeguard( domain architecture ID 10179627)

protein lifeguard similar to human protein lifeguard 2, an antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis, and regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 82-237 3.09e-70

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


:

Pssm-ID: 198410  Cd Length: 217  Bit Score: 217.02  E-value: 3.09e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561  82 PFSDSWIRRAFIIKVFLILSAQLVVTGAIVSVFLFW------------------PAFFVVLIVLACCGKLRRQVPANYIL 143
Cdd:cd10428     1 PFDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHdpvkkfvrknpwlyyvsyIVFFITYIALACCEGLRRRFPWNLIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561 144 LGLFTVLQGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHL 223
Cdd:cd10428    81 LGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHI 160

                         170
                  ....*....|....
gi 1952685561 224 LYAGLGTIVFSLQL 237
Cdd:cd10428   161 VYASLGALLFSLYL 174
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 82-237 3.09e-70

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 217.02  E-value: 3.09e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561  82 PFSDSWIRRAFIIKVFLILSAQLVVTGAIVSVFLFW------------------PAFFVVLIVLACCGKLRRQVPANYIL 143
Cdd:cd10428     1 PFDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHdpvkkfvrknpwlyyvsyIVFFITYIALACCEGLRRRFPWNLIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561 144 LGLFTVLQGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHL 223
Cdd:cd10428    81 LGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHI 160

                         170
                  ....*....|....
gi 1952685561 224 LYAGLGTIVFSLQL 237
Cdd:cd10428   161 VYASLGALLFSLYL 174
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 90-235 3.39e-26

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 102.64  E-value: 3.39e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561  90 RAFIIKVFLILSAQLVVTGAIVSVF--------------LFWPAFFVVLIVLAC----CGKLRRQVPANYILLGLFTVLQ 151
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVlsspallfpslhppLFWVLIIAPLGLLFGalllARKRKYSSNVALLLLLAFTLLM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561 152 GLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYAGLGTI 231
Cdd:pfam01027  81 GLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISYLGVL 160


                  ....
gi 1952685561 232 VFSL 235
Cdd:pfam01027 161 LFSG 164
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 89-234 5.45e-19

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 84.08  E-value: 5.45e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561  89 RRAFIIKVFLILSAQLVVTGAIVSV---------------FLFWPAFFV--VLIVLACCGKLRRQVPANYILLGLFTVLQ 151
Cdd:COG0670    19 LRKVLRNTYGLLALGLLLTALVAYLgmalpglaallfgspGLFWVLLIAplGLVFLLSKLANRANSAAALALLFAYTALM 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561 152 GLLLGAVSVFY----NAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYAG 227
Cdd:COG0670    99 GLTLSPILLVYtglsGPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQSPALSLAISV 178


                  ....*..
gi 1952685561 228 LGTIVFS 234
Cdd:COG0670   179 AGVLLFS 185
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 82-237 3.09e-70

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 217.02  E-value: 3.09e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561  82 PFSDSWIRRAFIIKVFLILSAQLVVTGAIVSVFLFW------------------PAFFVVLIVLACCGKLRRQVPANYIL 143
Cdd:cd10428     1 PFDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHdpvkkfvrknpwlyyvsyIVFFITYIALACCEGLRRRFPWNLIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561 144 LGLFTVLQGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHL 223
Cdd:cd10428    81 LGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHI 160

                         170
                  ....*....|....
gi 1952685561 224 LYAGLGTIVFSLQL 237
Cdd:cd10428   161 VYASLGALLFSLYL 174
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 73-234 1.07e-35

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 128.49  E-value: 1.07e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561  73 PDDSNNLAN-PFSDSWIRRAFIIKVFLILSAQLVVTGAIVSVF---------------LFWPAFFVVLIVLACCGKLRRQ 136
Cdd:cd10429    10 PDDFKYGTNvASAEPEIRMAFLRKVYSILSVQLLATTAVSALFylspsiktfvqshpwLFLISLIGSLILLIALYWKRHS 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561 137 VPANYILLGLFTVLQGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLII-YGILLLF 215
Cdd:cd10429    90 HPVNLILLSLFTLCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWALILlALIFQFF 169

                         170
                  ....*....|....*....
gi 1952685561 216 IRSYWLHLLYAGLGTIVFS 234
Cdd:cd10429   170 PYSPTFELVYAGLGALLFS 188
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 90-235 3.39e-26

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 102.64  E-value: 3.39e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561  90 RAFIIKVFLILSAQLVVTGAIVSVF--------------LFWPAFFVVLIVLAC----CGKLRRQVPANYILLGLFTVLQ 151
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVlsspallfpslhppLFWVLIIAPLGLLFGalllARKRKYSSNVALLLLLAFTLLM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561 152 GLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYAGLGTI 231
Cdd:pfam01027  81 GLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISYLGVL 160


                  ....
gi 1952685561 232 VFSL 235
Cdd:pfam01027 161 LFSG 164
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 88-235 2.82e-23

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 94.79  E-value: 2.82e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561  88 IRRAFIIKVFLILSAQLVVTGAIVSVFLF----WPA------FFVVLIVLAC-CGKLRRQVPANYILLGLFTVLQGLLLG 156
Cdd:cd06181     1 STKDFLRKVYMILALQLLLTAATATAFTVcdpgWYWspalmgLLTSMLALMAtAAMIRAKMPVNLILLFGFTGLMGYVVG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1952685561 157 AVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYAGLGTIVFSL 235
Cdd:cd06181    81 PLLFFYGPTILLRALGGTALVFFGLTVYALQARKDFLFLGGPLMAGLGFLLLSFLLNTFFYSPWLHLVAAAVGLVLFCG 159
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 89-234 3.62e-21

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 89.54  E-value: 3.62e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561  89 RRAFIIKVFLILSAQLVVTGA-------------IVSVFLFWPAFFVVLIVLACCGKLRRQ--VPANYILLGLFTVLQGL 153
Cdd:cd10432     2 LRSFMKKVYGLMAAGLLLTAVgayvgastpalllIAGSPLMWVLLIAELALVFGLSFRINKmsVATALPLFFAFAALTGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561 154 LLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYAGLGTIVF 233
Cdd:cd10432    82 TLSPILLVYTGASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQFAISAIGVLIF 161


                  .
gi 1952685561 234 S 234
Cdd:cd10432   162 S 162
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 89-234 5.45e-19

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 84.08  E-value: 5.45e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561  89 RRAFIIKVFLILSAQLVVTGAIVSV---------------FLFWPAFFV--VLIVLACCGKLRRQVPANYILLGLFTVLQ 151
Cdd:COG0670    19 LRKVLRNTYGLLALGLLLTALVAYLgmalpglaallfgspGLFWVLLIAplGLVFLLSKLANRANSAAALALLFAYTALM 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561 152 GLLLGAVSVFY----NAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYAG 227
Cdd:COG0670    99 GLTLSPILLVYtglsGPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQSPALSLAISV 178


                  ....*..
gi 1952685561 228 LGTIVFS 234
Cdd:COG0670   179 AGVLLFS 185
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 97-235 8.10e-08

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 51.82  E-value: 8.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561  97 FLILSAQLVVT--GAIVSVFLFWPAFFVVLIVLACCGKL-----RRQVPANYILLGLFTVLQGLLLG-----AVSVFYNA 164
Cdd:cd10433    11 YMLLSMTLAFSalGAGVSMAGGSPIMGLLLTLVGAYGLLfliekTRNSAWGIVLVFAFTGFMGYTLGpilnmYLALPNGG 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1952685561 165 EEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYAGLGTIVFSL 235
Cdd:cd10433    91 QIIMTALGGTAAIFFGLSAYALTTKKDFSFLGGFLFVGAIVLLLAAVANIFLQIPALSLAISAAFVLFSSG 161
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 94-237 9.16e-06

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 45.68  E-value: 9.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561  94 IKVFLILSAQLVVT--GAIVSVF---LFWPAFFVVL---IVLACCGKLRRQVPANYILLGLFTVLQGL----LLGAVSVF 161
Cdd:cd10430    13 KKVYLTLAVALLAAavGAYVHMViniGGLLTGLLSLglsLWLAFTPSTGKNEPKRLGLLLGFAFLTGAslgpLLDLVIAI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561 162 yNAEEVLWATAATALVTLSLTLFALQTK-WDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLH--LLYAGL----GTIVFS 234
Cdd:cd10430    93 -NPSIIVTAFLGTAVIFACFSLAALLAKrREYLYLGGLLSSALSILLLVSLANIFGGSKFLFqaELYLGLlvfcGFVLFD 171


                  ...
gi 1952685561 235 LQL 237
Cdd:cd10430   172 TQM 174
TgpA_N pfam11992
TgpA N-terminal domain; This domain can be found at the N terminus of TgpA from Pseudomonas ...
 98-214 1.84e-04

TgpA N-terminal domain; This domain can be found at the N terminus of TgpA from Pseudomonas aeruginosa. TgpA is a transglutaminase that plays a critical role in the viability of Pseudomonas aeruginosa. This domain is composed of 5 transmembrane helices.


Pssm-ID: 463423  Cd Length: 336  Bit Score: 42.42  E-value: 1.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561  98 LILSAQLVVTGAIVSVFLFWPAFFVVLIVLACCGKLRRQVPANYILLGLFTVLQGLLLGAVSVFYNAEEVLWATAATALV 177
Cdd:pfam11992   2 LLLAAALALLPLLSGLPWWVPALLLVALVLAVGALLRRLRLPRWRLPPALLLAGLLVLALLLTLFLAGTALLGLSLGLLA 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1952685561 178 TLSLTLFALQTKW-------DF--------------TMLNGMLFVLLFVLIIYGILLL 214
Cdd:pfam11992  82 AVALLLLALLLKLlevrlrrDAlaglllllfllvpaALLSQSLGLLLFLLLALAFLLL 139
COG5373 COG5373
Uncharacterized membrane protein [Function unknown];
96-249 4.89e-04

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 444140 [Multi-domain]  Cd Length: 854  Bit Score: 41.91  E-value: 4.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561  96 VFLILSAQLVVTGAIVSVF-----LFWPAFFVVLIVLACCGKLRRQVPANYILLGLFTVLQGLLLgavsvfYNAEEVLWA 170
Cdd:COG5373   338 LFGTPLVAFALQLALVADSgyglaLSALALALLYLALALLLRRRRPALLALAFLALGVAFATLAI------PLALSARWT 411

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561 171 TAATALVTLSLTLFALQTKWDFTMLNGMLFVLL---FVLIIYGILLLFIRSY--WLHLLYAGLGTIVFSLQLERWRDAGL 245
Cdd:COG5373   412 AALWALEGLGLLWLGLRQWRLLLRWWALLLQLAplaALLAAYWPVANLAGSYlwALLALALAALFAALALRLARRRSAGL 491


                  ....
gi 1952685561 246 RGAG 249
Cdd:COG5373   492 RLWG 495
SLC5sbd cd10322
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ...
 93-207 4.73e-03

Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.


Pssm-ID: 271357 [Multi-domain]  Cd Length: 454  Bit Score: 38.30  E-value: 4.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685561  93 IIKVFLILSAQLVVTGAIVSVFLFWP------AFFVVLIVLACCGKLRRQVPANYILLGLFTVlqGLLLGAVSVFYNAEE 166
Cdd:cd10322   122 IIALIPYLALQLIGGGYILSTLLGIPytvaviIAAVIVILYTVFGGMRAVAWTDVIQGIVMLI--GVLVAAIFILSKVGG 199

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1952685561 167 VLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLI 207
Cdd:cd10322   200 GGFSALAAALPALLLALGPGGGLGWSTILSLILLTGLGVLA 240
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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