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Conserved domains on  [gi|1958789032|ref|XP_038934900|]
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zinc finger protein 563 isoform X1 [Rattus norvegicus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
135-296 7.03e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 7.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 135 KPYKCQQCGKAFSSSSKVRRHERT--HTGE--KPYMCNH--CGKAFPSRGSLRRHDRIHSGEKPFVCKY--CGKAFTGQS 206
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 207 SLPRHERIH-----SGEKPYVCKY--CGKCFISSSTCRVHERTHTGEKLYVCN--LCNKAVTTRTSLRNHERIHSGEKPY 277
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*....
gi 1958789032 278 VCEQCGKGFISSGTFRIHE 296
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
303-399 2.75e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 303 KPYRCKECGKAFTIQSSLQRHERIHTREKPYDC--KECGKAFSGYSSLRRHERIHSGERPYAC-KQCGKAFPALGDCQRH 379
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100
                  ....*....|....*....|
gi 1958789032 380 EQIHTGEKPYICKQCGKAFT 399
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPS 131
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
135-296 7.03e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 7.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 135 KPYKCQQCGKAFSSSSKVRRHERT--HTGE--KPYMCNH--CGKAFPSRGSLRRHDRIHSGEKPFVCKY--CGKAFTGQS 206
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 207 SLPRHERIH-----SGEKPYVCKY--CGKCFISSSTCRVHERTHTGEKLYVCN--LCNKAVTTRTSLRNHERIHSGEKPY 277
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*....
gi 1958789032 278 VCEQCGKGFISSGTFRIHE 296
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
303-399 2.75e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 303 KPYRCKECGKAFTIQSSLQRHERIHTREKPYDC--KECGKAFSGYSSLRRHERIHSGERPYAC-KQCGKAFPALGDCQRH 379
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100
                  ....*....|....*....|
gi 1958789032 380 EQIHTGEKPYICKQCGKAFT 399
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPS 131
zf-H2C2_2 pfam13465
Zinc-finger double domain;
347-370 4.53e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.53e-04
                          10        20
                  ....*....|....*....|....
gi 1958789032 347 SLRRHERIHSGERPYACKQCGKAF 370
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
179-203 4.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.81e-04
                          10        20
                  ....*....|....*....|....*
gi 1958789032 179 SLRRHDRIHSGEKPFVCKYCGKAFT 203
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
135-296 7.03e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 7.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 135 KPYKCQQCGKAFSSSSKVRRHERT--HTGE--KPYMCNH--CGKAFPSRGSLRRHDRIHSGEKPFVCKY--CGKAFTGQS 206
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 207 SLPRHERIH-----SGEKPYVCKY--CGKCFISSSTCRVHERTHTGEKLYVCN--LCNKAVTTRTSLRNHERIHSGEKPY 277
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*....
gi 1958789032 278 VCEQCGKGFISSGTFRIHE 296
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
79-381 7.46e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 7.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032  79 ILIGLPPLNMHIPVQRGHRPYEYETYEDSLYKFREcGKAFLYSECYLKHENAhiiekPYKCQQCGKAFSSSSKVRRHERT 158
Cdd:COG5048   175 SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSY-SIPSSSSDQNLENSSS-----SLPLTTNSQLSPKSLLSQSPSSL 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 159 -HTGEKPYMCNHCGKAFPSRGSLR-RHDRIHSGE-----KPFVCKYCGKAFTGQSSLPRHER--IHSGE--KPYVCKY-- 225
Cdd:COG5048   249 sSSDSSSSASESPRSSLPTASSQSsSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYsl 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 226 CGKCFISSSTCRVHERTHTGEKLYVCNLCNkavttrtslRNHERIHSGEKPyvceqcgkgfiSSGTFRIHERIHTgEKPY 305
Cdd:COG5048   329 CGKLFSRNDALKRHILLHTSISPAKEKLLN---------SSSKFSPLLNNE-----------PPQSLQQYKDLKN-DKKS 387

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 306 RC--KECGKAFTIQSSLQRHERIHTREKPYDCK--ECGKAFSGYSSLRRHERIHSGERPYACKQCGKAFPALGDCQRHEQ 381
Cdd:COG5048   388 ETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 134-216 1.07e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 134 EKPYKCQ--QCGKAFSSSSKVRRHeRTHtgekpymcNHCGKAFPSRGSLRRHDRIHSGEKPFVCKYCGKAFTGQSSLPRH 211
Cdd:COG5189   347 GKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ....*
gi 1958789032 212 eRIHS 216
Cdd:COG5189   418 -RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
125-416 2.01e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 2.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 125 LKHENAHII----EKPYKC--QQCGKAFSSSSKVRRHERTHTGEKPYMCNHCGKafPSRGSLRRHDRIHSGEKPFV---C 195
Cdd:COG5048    46 LEHLTRHIRshtgEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSSLSSSSSNSNDnnlL 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 196 KYCGKAFTGQSSLPRHERIHSGEKPYVCKYCGKCFISSSTC----------------------RVHERTHTGeklYVCNL 253
Cdd:COG5048   124 SSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSnslhpplpanslskdpssnlslLISSNVSTS---IPSSS 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 254 CNKAVTTRTSLRNHERIHSGEKPYVCEQCGK-GFISSGTFRIHERIHTGEK--PYRCKECGKAFTIQSSLQRHERIHT-- 328
Cdd:COG5048   201 ENSPLSSSYSIPSSSSDQNLENSSSSLPLTTnSQLSPKSLLSQSPSSLSSSdsSSSASESPRSSLPTASSQSSSPNESds 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 329 -----REKPYDCKECGKAFSGYSSLRRHER--IHSGE--RPYAC--KQCGKAFPALGDCQRHEQIHTGEKPYICK--QCG 395
Cdd:COG5048   281 ssekgFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSS 360

                         330       340
                  ....*....|....*....|.
gi 1958789032 396 KAFTRCGSLRIHEKTHARQNS 416
Cdd:COG5048   361 SKFSPLLNNEPPQSLQQYKDL 381
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
303-399 2.75e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 303 KPYRCKECGKAFTIQSSLQRHERIHTREKPYDC--KECGKAFSGYSSLRRHERIHSGERPYAC-KQCGKAFPALGDCQRH 379
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100
                  ....*....|....*....|
gi 1958789032 380 EQIHTGEKPYICKQCGKAFT 399
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPS 131
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
163-411 3.25e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 3.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 163 KPYMCNHCGKAFPSRGSLRRHDRIHSGEKPFVCKY--CGKAFTGQSSLPRHERIHSGEKPYVCKYCG------KCFISSS 234
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 235 TCRVHERTHTGeklyvCNLCNKAVTTRTSLRNHERIHSGEKPYVCEQCGKGFISS----------------------GTF 292
Cdd:COG5048   112 SSSSNSNDNNL-----LSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnslhpplpanslskdpssnLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 293 RIHERIHTGEKPYRCKECGKAFTIQSSLQRHERIHTREKPYDC----------------------------KECGKAFSG 344
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttnsqlspksllsqspsslsssdssssaSESPRSSLP 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 345 YSSLRRHERIHSGER-------PYACKQCGKAFPALGDCQRHEQ--IHTGE--KPYIC--KQCGKAFTRCGSLRIHEKTH 411
Cdd:COG5048   267 TASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLH 346
zf-H2C2_2 pfam13465
Zinc-finger double domain;
347-370 4.53e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.53e-04
                          10        20
                  ....*....|....*....|....
gi 1958789032 347 SLRRHERIHSGERPYACKQCGKAF 370
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
179-203 4.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.81e-04
                          10        20
                  ....*....|....*....|....*
gi 1958789032 179 SLRRHDRIHSGEKPFVCKYCGKAFT 203
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
319-343 5.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.85e-04
                          10        20
                  ....*....|....*....|....*
gi 1958789032 319 SLQRHERIHTREKPYDCKECGKAFS 343
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
292-315 1.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.25e-03
                          10        20
                  ....*....|....*....|....
gi 1958789032 292 FRIHERIHTGEKPYRCKECGKAFT 315
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
153-174 1.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.37e-03
                          10        20
                  ....*....|....*....|..
gi 1958789032 153 RRHERTHTGEKPYMCNHCGKAF 174
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
247-396 1.85e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 247 KLYVCNLCNKAVTTRTSLRNHER--IHSGE--KPYVC--EQCGKGFISSGTFRIHERIHTGEKPYRCK--ECGKAFTI-- 316
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPll 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 317 ---QSSLQRHERIHTREKPYDC--KECGKAFSGYSSLRRHERIHSGERPYACK--QCGKAFPALGDCQRHEQIHTGEKPY 389
Cdd:COG5048   368 nnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447


                  ....*..
gi 1958789032 390 ICKQCGK 396
Cdd:COG5048   448 LCSILKS 454
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 161-244 1.88e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 1.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789032 161 GEKPYMCN--HCGKAFPSRGSLRRHdRIHSgekpfvckYCGKAFTGQSSLPRHERIHSGEKPYVCKYCGKCFISSSTCRV 238
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1958789032 239 HeRTHT 244
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
263-288 2.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.20e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958789032 263 SLRNHERIHSGEKPYVCEQCGKGFIS 288
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-232 3.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.11e-03
                          10        20
                  ....*....|....*....|...
gi 1958789032 210 RHERIHSGEKPYVCKYCGKCFIS 232
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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