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Conserved domains on  [gi|1958789127|ref|XP_038934933|]
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inactive serine/threonine-protein kinase PLK5 isoform X10 [Rattus norvegicus]

Protein Classification

POLO_box_1 domain-containing protein( domain architecture ID 10191838)

POLO_box_1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
POLO_box_1 cd13118
First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5; The polo-like Ser ...
 139-226 1.24e-31

First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5; The polo-like Ser/Thr kinases (Plk1, Plk2/Snk, Plk3/Prk/Fnk, Plk4/Sak, and the inactive kinase Plk5) play various roles in cytokinesis and mitosis. At their C-terminus, they contain a tandemly repeated polo-box domain (in the case of Plk4, a tandem repeat of cryptic PBDs is found in the middle of the protein followed by a C-terminal single repeat), which appears to be involved in autoinhibition and in mediating the subcellular localization. The latter may be controlled via interactions between the polo-box domain and phospho-peptide motifs. The phosphopeptide binding site is formed at the interface between the two tandemly repeated PBDs. The PBDs of Plk4/Sak appear unique in participating in homodimer interactions, though it is not clear whether and how they interact with phosphopeptides.


:

Pssm-ID: 240561  Cd Length: 91  Bit Score: 113.57  E-value: 1.24e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789127 139 SVLWAPKWVDYSLKYGFGYQLSDGGSGVLFRDGSHMALRPPGGHVSYQPDQGTLWIFALRD--VPGPLRAKLAVLRLFAC 216
Cdd:cd13118     1 PPVWVSKWVDYSNKYGLGYQLSDGSVGVLFNDSTKMVLSPDGKHVQYIERNGEESELTRSDdsYPPDLAKKVTLLKYFRN 80

                          90
                  ....*....|
gi 1958789127 217 YMQRRLREEG 226
Cdd:cd13118    81 YMEEHLSKGG 90
 
Name Accession Description Interval E-value
POLO_box_1 cd13118
First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5; The polo-like Ser ...
 139-226 1.24e-31

First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5; The polo-like Ser/Thr kinases (Plk1, Plk2/Snk, Plk3/Prk/Fnk, Plk4/Sak, and the inactive kinase Plk5) play various roles in cytokinesis and mitosis. At their C-terminus, they contain a tandemly repeated polo-box domain (in the case of Plk4, a tandem repeat of cryptic PBDs is found in the middle of the protein followed by a C-terminal single repeat), which appears to be involved in autoinhibition and in mediating the subcellular localization. The latter may be controlled via interactions between the polo-box domain and phospho-peptide motifs. The phosphopeptide binding site is formed at the interface between the two tandemly repeated PBDs. The PBDs of Plk4/Sak appear unique in participating in homodimer interactions, though it is not clear whether and how they interact with phosphopeptides.


Pssm-ID: 240561  Cd Length: 91  Bit Score: 113.57  E-value: 1.24e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789127 139 SVLWAPKWVDYSLKYGFGYQLSDGGSGVLFRDGSHMALRPPGGHVSYQPDQGTLWIFALRD--VPGPLRAKLAVLRLFAC 216
Cdd:cd13118     1 PPVWVSKWVDYSNKYGLGYQLSDGSVGVLFNDSTKMVLSPDGKHVQYIERNGEESELTRSDdsYPPDLAKKVTLLKYFRN 80

                          90
                  ....*....|
gi 1958789127 217 YMQRRLREEG 226
Cdd:cd13118    81 YMEEHLSKGG 90
POLO_box pfam00659
POLO box duplicated region;
152-208 7.29e-14

POLO box duplicated region;


Pssm-ID: 459894  Cd Length: 61  Bit Score: 65.22  E-value: 7.29e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789127 152 KYGFGYQLSDGGSGVLFRDGSHMALRPPGGHVSYQPDQGTLWIFALRDVPGP---LRAKL 208
Cdd:pfam00659   2 KYGIGYQLSNGTVQVNFNDHTKIILSPDGKAVTYIDKEGERRTYTLSTLSGCpedLKKKL 61
 
Name Accession Description Interval E-value
POLO_box_1 cd13118
First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5; The polo-like Ser ...
 139-226 1.24e-31

First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5; The polo-like Ser/Thr kinases (Plk1, Plk2/Snk, Plk3/Prk/Fnk, Plk4/Sak, and the inactive kinase Plk5) play various roles in cytokinesis and mitosis. At their C-terminus, they contain a tandemly repeated polo-box domain (in the case of Plk4, a tandem repeat of cryptic PBDs is found in the middle of the protein followed by a C-terminal single repeat), which appears to be involved in autoinhibition and in mediating the subcellular localization. The latter may be controlled via interactions between the polo-box domain and phospho-peptide motifs. The phosphopeptide binding site is formed at the interface between the two tandemly repeated PBDs. The PBDs of Plk4/Sak appear unique in participating in homodimer interactions, though it is not clear whether and how they interact with phosphopeptides.


Pssm-ID: 240561  Cd Length: 91  Bit Score: 113.57  E-value: 1.24e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789127 139 SVLWAPKWVDYSLKYGFGYQLSDGGSGVLFRDGSHMALRPPGGHVSYQPDQGTLWIFALRD--VPGPLRAKLAVLRLFAC 216
Cdd:cd13118     1 PPVWVSKWVDYSNKYGLGYQLSDGSVGVLFNDSTKMVLSPDGKHVQYIERNGEESELTRSDdsYPPDLAKKVTLLKYFRN 80

                          90
                  ....*....|
gi 1958789127 217 YMQRRLREEG 226
Cdd:cd13118    81 YMEEHLSKGG 90
POLO_box pfam00659
POLO box duplicated region;
152-208 7.29e-14

POLO box duplicated region;


Pssm-ID: 459894  Cd Length: 61  Bit Score: 65.22  E-value: 7.29e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789127 152 KYGFGYQLSDGGSGVLFRDGSHMALRPPGGHVSYQPDQGTLWIFALRDVPGP---LRAKL 208
Cdd:pfam00659   2 KYGIGYQLSNGTVQVNFNDHTKIILSPDGKAVTYIDKEGERRTYTLSTLSGCpedLKKKL 61
POLO_box cd13112
Polo-box domain (PBD), a C-terminal tandemly repeated region of polo-like kinases; The ...
 142-218 7.78e-07

Polo-box domain (PBD), a C-terminal tandemly repeated region of polo-like kinases; The polo-like Ser/Thr kinases (Plk1, Plk2/Snk, Plk3/Prk/Fnk, Plk4/Sak, and the inactive kinase Plk5) play various roles in cytokinesis and mitosis. At their C-terminus, they contain a tandemly repeated polo-box domain (in the case of Plk4, a tandem repeat of cryptic PBDs is found in the middle of the protein followed by a C-terminal single repeat), which appears to be involved in autoinhibition and in mediating the subcellular localization. The latter may be controlled via interactions between the polo-box domain and phospho-peptide motifs. The phosphopeptide binding site is formed at the interface between the two tandemly repeated PBDs. The PBDs of Plk4/Sak appear unique in participating in homodimer interactions, though it is not clear whether and how they interact with phosphopeptides.


Pssm-ID: 240556  Cd Length: 76  Bit Score: 46.26  E-value: 7.78e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958789127 142 WAPKWVDYslKYGFGYQLSDGGSGVLFRDGSHMALRPPGGHVSY-QPDqGTLWIFALRDVPGPLRAKLAVLRLFACYM 218
Cdd:cd13112     2 TLKVWYFT--KYGIGQLLSTGSVEILFNDGTKLILSPDGSSLKYyDPD-GQLTRYYLSELPSELRSKLEYLNTFVTHV 76
POLO_box_Plk4_3 cd13116
C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak); The polo-like Ser ...
 154-215 3.73e-03

C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak); The polo-like Ser/Thr kinases (Plk1, Plk2/Snk, Plk3/Prk/Fnk, Plk4/Sak, and the inactive kinase Plk5) play various roles in cytokinesis and mitosis. At their C-terminus, they contain a tandemly repeated polo-box domain (in the case of Plk4, a tandem repeat of cryptic PBDs is found in the middle of the protein followed by a C-terminal single repeat), which appears to be involved in autoinhibition and in mediating the subcellular localization. The latter may be controlled via interactions between the polo-box domain and phospho-peptide motifs. The phosphopeptide binding site is formed at the interface between the two tandemly repeated PBDs. The PBDs of Plk4/Sak appear unique in participating in homodimer interactions, though it is not clear whether and how they interact with phosphopeptides.


Pssm-ID: 240559  Cd Length: 81  Bit Score: 35.64  E-value: 3.73e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958789127 154 GFGYQLSDGGSGVLFRDGSHMALRPPGGH-VSYQPDQGTLWIFALRDV-PGPLRAKL----AVLRLFA 215
Cdd:cd13116    14 GWASQLSSGEIWVQYNDGSQLTVSPNRSStITYTSSDGTVTRYNQSDSlPEHVREKLshlpMVIKLLV 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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