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Conserved domains on  [gi|1958792706|ref|XP_038936152|]
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DENN domain-containing protein 3 isoform X5 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN super family cl11519
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 1-61 2.58e-22

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


The actual alignment was detected with superfamily member pfam02141:

Pssm-ID: 472208  Cd Length: 186  Bit Score: 95.33  E-value: 2.58e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958792706   1 MAECFVAYVHPLQWQHTFVPILSGQMLDFVMAPTSFLMGCHLDHFEEVRKEADGLVLIDID 61
Cdd:pfam02141 124 VAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFIIGVHSRYFDLLEDPLDDVVLVDLD 184
WD40 COG2319
WD40 repeat [General function prediction only];
696-968 2.45e-13

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 2.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 696 GKVVVFDASSWTIHQHcFKVGSSKVNCMVM-AEHSQVWVGSEDSVIYIINVHSMSCNKQLTDHRSAVTGLAV-PSGKKps 773
Cdd:COG2319   142 GTVRLWDLATGKLLRT-LTGHSGAVTSVAFsPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFsPDGKL-- 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 774 aVYSCSLDGTVLAWNVSTLRVISRFQLQHGDLMSISLHNDR---VFCCTARSILVVTLQGfvRQELRIQPSEEPSASFLA 850
Cdd:COG2319   219 -LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrllASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVA 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 851 IqlLPEEQQLwVACTGVSELYIWSLKDlGQPPQ--KTHLQDCTEVTCMiRVKRQIWVGGRGlsqgktrGKIYVMDVEKVT 928
Cdd:COG2319   296 F--SPDGKLL-ASGSDDGTVRLWDLAT-GKLLRtlTGHTGAVRSVAFS-PDGKTLASGSDD-------GTVRLWDLATGE 363

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1958792706 929 LEKELVAHSDTVRTLC-SAEDRYVLSgaGGEEGKIAIWKVE 968
Cdd:COG2319   364 LLRTLTGHTGAVTSVAfSPDGRTLAS--GSADGTVRLWDLA 402
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 127-189 2.60e-13

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 65.77  E-value: 2.60e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958792706  127 NCKIQHITLQLLVGIFREVKNHLNY------EHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKAR 189
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRElrkepgPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 1-61 2.58e-22

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 95.33  E-value: 2.58e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958792706   1 MAECFVAYVHPLQWQHTFVPILSGQMLDFVMAPTSFLMGCHLDHFEEVRKEADGLVLIDID 61
Cdd:pfam02141 124 VAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFIIGVHSRYFDLLEDPLDDVVLVDLD 184
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 2-61 7.59e-20

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 88.02  E-value: 7.59e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958792706    2 AECFVAYVHPLQWQHTFVPILSGQMLDFVMAPTSFLMGCHLDHFEEVRKEADG-LVLIDID 61
Cdd:smart00799 121 IEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGVHSSYFEEVKELPDEdVVVVDLD 181
WD40 COG2319
WD40 repeat [General function prediction only];
696-968 2.45e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 2.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 696 GKVVVFDASSWTIHQHcFKVGSSKVNCMVM-AEHSQVWVGSEDSVIYIINVHSMSCNKQLTDHRSAVTGLAV-PSGKKps 773
Cdd:COG2319   142 GTVRLWDLATGKLLRT-LTGHSGAVTSVAFsPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFsPDGKL-- 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 774 aVYSCSLDGTVLAWNVSTLRVISRFQLQHGDLMSISLHNDR---VFCCTARSILVVTLQGfvRQELRIQPSEEPSASFLA 850
Cdd:COG2319   219 -LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrllASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVA 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 851 IqlLPEEQQLwVACTGVSELYIWSLKDlGQPPQ--KTHLQDCTEVTCMiRVKRQIWVGGRGlsqgktrGKIYVMDVEKVT 928
Cdd:COG2319   296 F--SPDGKLL-ASGSDDGTVRLWDLAT-GKLLRtlTGHTGAVRSVAFS-PDGKTLASGSDD-------GTVRLWDLATGE 363

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1958792706 929 LEKELVAHSDTVRTLC-SAEDRYVLSgaGGEEGKIAIWKVE 968
Cdd:COG2319   364 LLRTLTGHTGAVTSVAfSPDGRTLAS--GSADGTVRLWDLA 402
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 127-189 2.60e-13

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 65.77  E-value: 2.60e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958792706  127 NCKIQHITLQLLVGIFREVKNHLNY------EHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKAR 189
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRElrkepgPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 711-966 4.53e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.75  E-value: 4.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 711 HCFKVGSSKVNCMVMAEHSQ-VWVGSEDSVIYIINVHSMSCNKQLTDHRSAVTG-LAVPSGKKpsaVYSCSLDGTVLAWN 788
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDvAASADGTY---LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 789 VSTLRVISRFQlQH-GDLMSISLHNDR--VFCCTA-RSI---------LVVTLQG---FVRQeLRIQP------------ 840
Cdd:cd00200    80 LETGECVRTLT-GHtSYVSSVAFSPDGriLSSSSRdKTIkvwdvetgkCLTTLRGhtdWVNS-VAFSPdgtfvasssqdg 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 841 --------SEEPSASF-------LAIQLLPEEQQLwVACTGVSELYIWSLKDlgqppqKTHLQDCTE-----VTCMIRVK 900
Cdd:cd00200   158 tiklwdlrTGKCVATLtghtgevNSVAFSPDGEKL-LSSSSDGTIKLWDLST------GKCLGTLRGhengvNSVAFSPD 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958792706 901 RQIwvggrgLSQGKTRGKIYVMDVEKVTLEKELVAHSDTVRTLCSAED-RYVLSGAggEEGKIAIWK 966
Cdd:cd00200   231 GYL------LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgKRLASGS--ADGTIRIWD 289
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 156-191 7.93e-04

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 37.94  E-value: 7.93e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1958792706 156 FNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKARLN 191
Cdd:pfam03455   1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLE 36
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 1-61 2.58e-22

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 95.33  E-value: 2.58e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958792706   1 MAECFVAYVHPLQWQHTFVPILSGQMLDFVMAPTSFLMGCHLDHFEEVRKEADGLVLIDID 61
Cdd:pfam02141 124 VAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFIIGVHSRYFDLLEDPLDDVVLVDLD 184
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 2-61 7.59e-20

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 88.02  E-value: 7.59e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958792706    2 AECFVAYVHPLQWQHTFVPILSGQMLDFVMAPTSFLMGCHLDHFEEVRKEADG-LVLIDID 61
Cdd:smart00799 121 IEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGVHSSYFEEVKELPDEdVVVVDLD 181
WD40 COG2319
WD40 repeat [General function prediction only];
696-968 2.45e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 2.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 696 GKVVVFDASSWTIHQHcFKVGSSKVNCMVM-AEHSQVWVGSEDSVIYIINVHSMSCNKQLTDHRSAVTGLAV-PSGKKps 773
Cdd:COG2319   142 GTVRLWDLATGKLLRT-LTGHSGAVTSVAFsPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFsPDGKL-- 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 774 aVYSCSLDGTVLAWNVSTLRVISRFQLQHGDLMSISLHNDR---VFCCTARSILVVTLQGfvRQELRIQPSEEPSASFLA 850
Cdd:COG2319   219 -LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrllASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVA 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 851 IqlLPEEQQLwVACTGVSELYIWSLKDlGQPPQ--KTHLQDCTEVTCMiRVKRQIWVGGRGlsqgktrGKIYVMDVEKVT 928
Cdd:COG2319   296 F--SPDGKLL-ASGSDDGTVRLWDLAT-GKLLRtlTGHTGAVRSVAFS-PDGKTLASGSDD-------GTVRLWDLATGE 363

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1958792706 929 LEKELVAHSDTVRTLC-SAEDRYVLSgaGGEEGKIAIWKVE 968
Cdd:COG2319   364 LLRTLTGHTGAVTSVAfSPDGRTLAS--GSADGTVRLWDLA 402
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 127-189 2.60e-13

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 65.77  E-value: 2.60e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958792706  127 NCKIQHITLQLLVGIFREVKNHLNY------EHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKAR 189
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRElrkepgPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 711-966 4.53e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.75  E-value: 4.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 711 HCFKVGSSKVNCMVMAEHSQ-VWVGSEDSVIYIINVHSMSCNKQLTDHRSAVTG-LAVPSGKKpsaVYSCSLDGTVLAWN 788
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDvAASADGTY---LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 789 VSTLRVISRFQlQH-GDLMSISLHNDR--VFCCTA-RSI---------LVVTLQG---FVRQeLRIQP------------ 840
Cdd:cd00200    80 LETGECVRTLT-GHtSYVSSVAFSPDGriLSSSSRdKTIkvwdvetgkCLTTLRGhtdWVNS-VAFSPdgtfvasssqdg 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 841 --------SEEPSASF-------LAIQLLPEEQQLwVACTGVSELYIWSLKDlgqppqKTHLQDCTE-----VTCMIRVK 900
Cdd:cd00200   158 tiklwdlrTGKCVATLtghtgevNSVAFSPDGEKL-LSSSSDGTIKLWDLST------GKCLGTLRGhengvNSVAFSPD 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958792706 901 RQIwvggrgLSQGKTRGKIYVMDVEKVTLEKELVAHSDTVRTLCSAED-RYVLSGAggEEGKIAIWK 966
Cdd:cd00200   231 GYL------LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgKRLASGS--ADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
692-968 3.79e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 3.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 692 ALNEGKVVVFDASSwTIHQHCFKVGSSKVNCMVMAEHSQVWV-GSEDSVIYIINVHSMSCNKQLTDHRSAVTGLAV-PSG 769
Cdd:COG2319    96 ASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLAsGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFsPDG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 770 KKpsaVYSCSLDGTVLAWNVSTLRVISRFQLQHGDLMSISLHND--RVFCCTA-RSILVVTLQGfvRQELRIQPSEEPSA 846
Cdd:COG2319   175 KL---LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkLLASGSAdGTVRLWDLAT--GKLLRTLTGHSGSV 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 847 SFLAIqlLPEEQQLwVACTGVSELYIWSLKDlGQPPQK-THLQDctEVTCMIRVK--RQIWVGGRGlsqgktrGKIYVMD 923
Cdd:COG2319   250 RSVAF--SPDGRLL-ASGSADGTVRLWDLAT-GELLRTlTGHSG--GVNSVAFSPdgKLLASGSDD-------GTVRLWD 316

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1958792706 924 VEKVTLEKELVAHSDTVRTLC-SAEDRYVLSgaGGEEGKIAIWKVE 968
Cdd:COG2319   317 LATGKLLRTLTGHTGAVRSVAfSPDGKTLAS--GSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
696-791 3.50e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 3.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 696 GKVVVFDASSWTIhQHCFKVGSSKVNCMVMAEHSQ-VWVGSEDSVIYIINVHSMSCNKQLTDHRSAVTGLAV-PSGKKps 773
Cdd:COG2319   310 GTVRLWDLATGKL-LRTLTGHTGAVRSVAFSPDGKtLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFsPDGRT-- 386

                          90
                  ....*....|....*...
gi 1958792706 774 aVYSCSLDGTVLAWNVST 791
Cdd:COG2319   387 -LASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 691-817 5.10e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.17  E-value: 5.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 691 CALNEGKVVVFDASSW----TIHQHcfkvgSSKVNCM-VMAEHSQVWVGSEDSVIYIINVHSMSCNKQLTDHRSAVTGLA 765
Cdd:cd00200   152 SSSQDGTIKLWDLRTGkcvaTLTGH-----TGEVNSVaFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVA 226

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958792706 766 V-PSGKkpsAVYSCSLDGTVLAWNVSTLRVisrfqlqhgdLMSISLHNDRVFC 817
Cdd:cd00200   227 FsPDGY---LLASGSEDGTIRVWDLRTGEC----------VQTLSGHTNSVTS 266
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 750-965 1.69e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.63  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 750 CNKQLTDHRSAVTGLAV-PSGKKpsaVYSCSLDGTVLAWNVSTLRVISRFQLQHGDLMSISLHNDRVFCCTA---RSILV 825
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFsPDGKL---LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGssdKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792706 826 VTLQGfvRQELRIQPSEEpsASFLAIQLLPEEQqlWVACTGV-SELYIWslkDLGQPPQKTHLQDCTEVTCMIRVKRQiw 904
Cdd:cd00200    78 WDLET--GECVRTLTGHT--SYVSSVAFSPDGR--ILSSSSRdKTIKVW---DVETGKCLTTLRGHTDWVNSVAFSPD-- 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958792706 905 vgGRGLSQGKTRGKIYVMDVEKVTLEKELVAHSDTVRTLCSAEDRYVLSgAGGEEGKIAIW 965
Cdd:cd00200   147 --GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLL-SSSSDGTIKLW 204
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 156-191 7.93e-04

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 37.94  E-value: 7.93e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1958792706 156 FNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKARLN 191
Cdd:pfam03455   1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLE 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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