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Conserved domains on  [gi|1958800907|ref|XP_038938908|]
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serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X4 [Rattus norvegicus]

Protein Classification

WW-binding domain-containing protein( domain architecture ID 10633234)

WW-binding domain-containing protein similar to serine/threonine-protein phosphatase 4 regulatory subunit 1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WRNPLPNID pfam15017
Putative WW-binding domain and destruction box; This short conserved region is a putative ...
 433-458 1.52e-03

Putative WW-binding domain and destruction box; This short conserved region is a putative destruction-box, with its RxxLxxI sequence motif, though the homology is not absolute. The domain occurs on a number of tumourigenic proteins, on some RNA-binding proteins and serine-threonine regulatory proteins. The second less well-conserved motif, WITPS, is a potential WW domain ligand-binding motif for recruiting proteins to their substrates. WW domains bind tightly to short proline-containing peptides that are typically in regions of native disordered polypeptide, as this family is as it lies between a PIN domain and a zinc-binding domain.


:

Pssm-ID: 464448  Cd Length: 56  Bit Score: 37.71  E-value: 1.52e-03
                          10        20
                  ....*....|....*....|....*..
gi 1958800907 433 FNSFHFWRTPLPQIDLD-KELQQDPGE 458
Cdd:pfam15017   3 FNSFLFWRNPLPEIDLElEELLEEEDE 29
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 341-515 6.35e-03

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 6.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958800907 341 PEDAPSDLSAPHSSARLDGT---LEGCAAETPGDSAGDMRVPADSSLlctlSSESPQEAASDAESGKKHDNNSKSASRPD 417
Cdd:PRK07764  650 PEHHPKHVAVPDASDGGDGWpakAGGAAPAAPPPAPAPAAPAAPAGA----APAQPAPAPAATPPAGQADDPAAQPPQAA 725

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958800907 418 VGTSSPEPTPLDQemfnsfhfwrTPLPQidlDKELQQDPGERPSPERTGDAPAAPVPGSPSITMATRKELEEMIENLEPH 497
Cdd:PRK07764  726 QGASAPSPAADDP----------VPLPP---EPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPS 792

                         170
                  ....*....|....*...
gi 1958800907 498 MDDPDVKAQVEVLSAALR 515
Cdd:PRK07764  793 MDDEDRRDAEEVAMELLE 810
 
Name Accession Description Interval E-value
WRNPLPNID pfam15017
Putative WW-binding domain and destruction box; This short conserved region is a putative ...
 433-458 1.52e-03

Putative WW-binding domain and destruction box; This short conserved region is a putative destruction-box, with its RxxLxxI sequence motif, though the homology is not absolute. The domain occurs on a number of tumourigenic proteins, on some RNA-binding proteins and serine-threonine regulatory proteins. The second less well-conserved motif, WITPS, is a potential WW domain ligand-binding motif for recruiting proteins to their substrates. WW domains bind tightly to short proline-containing peptides that are typically in regions of native disordered polypeptide, as this family is as it lies between a PIN domain and a zinc-binding domain.


Pssm-ID: 464448  Cd Length: 56  Bit Score: 37.71  E-value: 1.52e-03
                          10        20
                  ....*....|....*....|....*..
gi 1958800907 433 FNSFHFWRTPLPQIDLD-KELQQDPGE 458
Cdd:pfam15017   3 FNSFLFWRNPLPEIDLElEELLEEEDE 29
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 341-515 6.35e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 6.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958800907 341 PEDAPSDLSAPHSSARLDGT---LEGCAAETPGDSAGDMRVPADSSLlctlSSESPQEAASDAESGKKHDNNSKSASRPD 417
Cdd:PRK07764  650 PEHHPKHVAVPDASDGGDGWpakAGGAAPAAPPPAPAPAAPAAPAGA----APAQPAPAPAATPPAGQADDPAAQPPQAA 725

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958800907 418 VGTSSPEPTPLDQemfnsfhfwrTPLPQidlDKELQQDPGERPSPERTGDAPAAPVPGSPSITMATRKELEEMIENLEPH 497
Cdd:PRK07764  726 QGASAPSPAADDP----------VPLPP---EPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPS 792

                         170
                  ....*....|....*...
gi 1958800907 498 MDDPDVKAQVEVLSAALR 515
Cdd:PRK07764  793 MDDEDRRDAEEVAMELLE 810
 
Name Accession Description Interval E-value
WRNPLPNID pfam15017
Putative WW-binding domain and destruction box; This short conserved region is a putative ...
 433-458 1.52e-03

Putative WW-binding domain and destruction box; This short conserved region is a putative destruction-box, with its RxxLxxI sequence motif, though the homology is not absolute. The domain occurs on a number of tumourigenic proteins, on some RNA-binding proteins and serine-threonine regulatory proteins. The second less well-conserved motif, WITPS, is a potential WW domain ligand-binding motif for recruiting proteins to their substrates. WW domains bind tightly to short proline-containing peptides that are typically in regions of native disordered polypeptide, as this family is as it lies between a PIN domain and a zinc-binding domain.


Pssm-ID: 464448  Cd Length: 56  Bit Score: 37.71  E-value: 1.52e-03
                          10        20
                  ....*....|....*....|....*..
gi 1958800907 433 FNSFHFWRTPLPQIDLD-KELQQDPGE 458
Cdd:pfam15017   3 FNSFLFWRNPLPEIDLElEELLEEEDE 29
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 341-515 6.35e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 6.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958800907 341 PEDAPSDLSAPHSSARLDGT---LEGCAAETPGDSAGDMRVPADSSLlctlSSESPQEAASDAESGKKHDNNSKSASRPD 417
Cdd:PRK07764  650 PEHHPKHVAVPDASDGGDGWpakAGGAAPAAPPPAPAPAAPAAPAGA----APAQPAPAPAATPPAGQADDPAAQPPQAA 725

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958800907 418 VGTSSPEPTPLDQemfnsfhfwrTPLPQidlDKELQQDPGERPSPERTGDAPAAPVPGSPSITMATRKELEEMIENLEPH 497
Cdd:PRK07764  726 QGASAPSPAADDP----------VPLPP---EPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPS 792

                         170
                  ....*....|....*...
gi 1958800907 498 MDDPDVKAQVEVLSAALR 515
Cdd:PRK07764  793 MDDEDRRDAEEVAMELLE 810
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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