NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958657542|ref|XP_038941561|]
View 

centrosomal protein of 95 kDa isoform X3 [Rattus norvegicus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DUF5745 pfam19016
Domain of unknown function (DUF5745); This is a domain of unknown function found in ...
 51-107 8.98e-24

Domain of unknown function (DUF5745); This is a domain of unknown function found in Platyhelminthes. It shows homology with the calponin homology (CH) domain.


:

Pssm-ID: 465945  Cd Length: 59  Bit Score: 94.17  E-value: 8.98e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958657542  51 LIVIPRSQEDNAHNVQAVIDSLALDYLQVSLSHITGENIVKGDKGSIKNLLEIFDGL 107
Cdd:pfam19016   3 VIRNPSSVEDRIHNIQAVIDSLANDVLNVDLSHITPEDIVDGDPEAIRNLLEIFVGI 59
 
Name Accession Description Interval E-value
DUF5745 pfam19016
Domain of unknown function (DUF5745); This is a domain of unknown function found in ...
 51-107 8.98e-24

Domain of unknown function (DUF5745); This is a domain of unknown function found in Platyhelminthes. It shows homology with the calponin homology (CH) domain.


Pssm-ID: 465945  Cd Length: 59  Bit Score: 94.17  E-value: 8.98e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958657542  51 LIVIPRSQEDNAHNVQAVIDSLALDYLQVSLSHITGENIVKGDKGSIKNLLEIFDGL 107
Cdd:pfam19016   3 VIRNPSSVEDRIHNIQAVIDSLANDVLNVDLSHITPEDIVDGDPEAIRNLLEIFVGI 59
CH_NAV2-like cd21212
calponin homology (CH) domain found in neuron navigator (NAV) 2, NAV3, and similar proteins; ...
 39-101 4.99e-03

calponin homology (CH) domain found in neuron navigator (NAV) 2, NAV3, and similar proteins; This family includes neuron navigator 2 (NAV2) and NAV3, both of which contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs. NAV2, also called helicase APC down-regulated 1 (HELAD1), pore membrane and/or filament-interacting-like protein 2 (POMFIL2), retinoic acid inducible in neuroblastoma 1 (RAINB1), Steerin-2 (STEERIN2), or Unc-53 homolog 2 (unc53H2), possesses 3' to 5' helicase activity and exonuclease activity. It is involved in neuronal development, specifically in the development of different sensory organs. NAV3, also called pore membrane and/or filament-interacting-like protein 1 (POMFIL1), Steerin-3 (STEERIN3), or Unc-53 homolog 3 (unc53H3), may regulate IL2 production by T-cells. It may be involved in neuron regeneration.


Pssm-ID: 409061  Cd Length: 105  Bit Score: 36.79  E-value: 4.99e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958657542  39 LYQSILGEKVPDLIVIPRSQEDNAHNVQAvidslALDYLQ---VSLSHITGENIVKGDKGSIKNLL 101
Cdd:cd21212    38 LIEAVAGEKVPGIHSRPKTRAQKLENIQA-----CLQFLAalgVDVQGITAEDIVDGNLKAILGLF 98
 
Name Accession Description Interval E-value
DUF5745 pfam19016
Domain of unknown function (DUF5745); This is a domain of unknown function found in ...
 51-107 8.98e-24

Domain of unknown function (DUF5745); This is a domain of unknown function found in Platyhelminthes. It shows homology with the calponin homology (CH) domain.


Pssm-ID: 465945  Cd Length: 59  Bit Score: 94.17  E-value: 8.98e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958657542  51 LIVIPRSQEDNAHNVQAVIDSLALDYLQVSLSHITGENIVKGDKGSIKNLLEIFDGL 107
Cdd:pfam19016   3 VIRNPSSVEDRIHNIQAVIDSLANDVLNVDLSHITPEDIVDGDPEAIRNLLEIFVGI 59
CH_NAV2-like cd21212
calponin homology (CH) domain found in neuron navigator (NAV) 2, NAV3, and similar proteins; ...
 39-101 4.99e-03

calponin homology (CH) domain found in neuron navigator (NAV) 2, NAV3, and similar proteins; This family includes neuron navigator 2 (NAV2) and NAV3, both of which contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs. NAV2, also called helicase APC down-regulated 1 (HELAD1), pore membrane and/or filament-interacting-like protein 2 (POMFIL2), retinoic acid inducible in neuroblastoma 1 (RAINB1), Steerin-2 (STEERIN2), or Unc-53 homolog 2 (unc53H2), possesses 3' to 5' helicase activity and exonuclease activity. It is involved in neuronal development, specifically in the development of different sensory organs. NAV3, also called pore membrane and/or filament-interacting-like protein 1 (POMFIL1), Steerin-3 (STEERIN3), or Unc-53 homolog 3 (unc53H3), may regulate IL2 production by T-cells. It may be involved in neuron regeneration.


Pssm-ID: 409061  Cd Length: 105  Bit Score: 36.79  E-value: 4.99e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958657542  39 LYQSILGEKVPDLIVIPRSQEDNAHNVQAvidslALDYLQ---VSLSHITGENIVKGDKGSIKNLL 101
Cdd:cd21212    38 LIEAVAGEKVPGIHSRPKTRAQKLENIQA-----CLQFLAalgVDVQGITAEDIVDGNLKAILGLF 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH