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Conserved domains on  [gi|1958674738|ref|XP_038947432|]
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denticleless protein homolog isoform X1 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-329 6.84e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.74  E-value: 6.84e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738   3 HILAVANEEGFVRLYNTESQTskktCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELMGTCKGHQCSLK 82
Cdd:COG2319   133 KTLASGSADGTVRLWDLATGK----LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVR 208
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738  83 SVAFSKFQKAVFcTGGRDGNIMIWDTrcnkkdgfyrqvnqisgahntadkqtpskpkkkQNSKGLAPSVDSQQSVTVVLF 162
Cdd:COG2319   209 SVAFSPDGKLLA-SGSADGTVRLWDL---------------------------------ATGKLLRTLTGHSGSVRSVAF 254
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 163 -QDENTVVSAGAvDGIIKVWDLRknytayrqepiasksflyPGTSTRKLGY-----SSLVLDSTGSTLFANCTDDNIYMF 236
Cdd:COG2319   255 sPDGRLLASGSA-DGTVRLWDLA------------------TGELLRTLTGhsggvNSVAFSPDGKLLASGSDDGTVRLW 315
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 237 NMTGLKtsPLAVFNGHQNSTFYVksSLSPDDQFLISGSSDEAAYIWKVSmPWHPPTVLLGHSQEVTSVCWCPsDFTKIAT 316
Cdd:COG2319   316 DLATGK--LLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTVRLWDLA-TGELLRTLTGHTGAVTSVAFSP-DGRTLAS 389
                         330
                  ....*....|...
gi 1958674738 317 CSDDNTLKIWRLN 329
Cdd:COG2319   390 GSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-329 6.84e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.74  E-value: 6.84e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738   3 HILAVANEEGFVRLYNTESQTskktCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELMGTCKGHQCSLK 82
Cdd:COG2319   133 KTLASGSADGTVRLWDLATGK----LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVR 208
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738  83 SVAFSKFQKAVFcTGGRDGNIMIWDTrcnkkdgfyrqvnqisgahntadkqtpskpkkkQNSKGLAPSVDSQQSVTVVLF 162
Cdd:COG2319   209 SVAFSPDGKLLA-SGSADGTVRLWDL---------------------------------ATGKLLRTLTGHSGSVRSVAF 254
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 163 -QDENTVVSAGAvDGIIKVWDLRknytayrqepiasksflyPGTSTRKLGY-----SSLVLDSTGSTLFANCTDDNIYMF 236
Cdd:COG2319   255 sPDGRLLASGSA-DGTVRLWDLA------------------TGELLRTLTGhsggvNSVAFSPDGKLLASGSDDGTVRLW 315
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 237 NMTGLKtsPLAVFNGHQNSTFYVksSLSPDDQFLISGSSDEAAYIWKVSmPWHPPTVLLGHSQEVTSVCWCPsDFTKIAT 316
Cdd:COG2319   316 DLATGK--LLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTVRLWDLA-TGELLRTLTGHTGAVTSVAFSP-DGRTLAS 389
                         330
                  ....*....|...
gi 1958674738 317 CSDDNTLKIWRLN 329
Cdd:COG2319   390 GSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
3-327 1.66e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 138.62  E-value: 1.66e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738   3 HILAVANEEGFVRLYNTESQTSKKTCfkewMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELMGTCKGHQCSLK 82
Cdd:cd00200    22 KLLATGSGDGTIKVWDLETGELLRTL----KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVS 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738  83 SVAFSKFQKaVFCTGGRDGNIMIWDTRCNKkdgfyrQVNQISGaHNtadkqtpskpkkkqnskglapsvdsqQSVTVVLF 162
Cdd:cd00200    98 SVAFSPDGR-ILSSSSRDKTIKVWDVETGK------CLTTLRG-HT--------------------------DWVNSVAF 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 163 QDENTVVSAGAVDGIIKVWDLRKNYTAYRqepiasksflYPGtstRKLGYSSLVLDSTGSTLFANCTDDNIYMFNMTGLK 242
Cdd:cd00200   144 SPDGTFVASSSQDGTIKLWDLRTGKCVAT----------LTG---HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 243 TspLAVFNGHQNSTFYVksSLSPDDQFLISGSSDEAAYIWKVsMPWHPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNT 322
Cdd:cd00200   211 C--LGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVWDL-RTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGT 284

                  ....*
gi 1958674738 323 LKIWR 327
Cdd:cd00200   285 IRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
287-326 3.87e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 3.87e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958674738  287 PWHPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIW 326
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
169-350 9.61e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.01  E-value: 9.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 169 VSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFlypgtstrklgysSLVLDSTGSTLFANCTDDNiymfnmtglKTSPLAV 248
Cdd:PLN00181  548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVW-------------SIDYSSADPTLLASGSDDG---------SVKLWSI 605
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 249 FNGHQNSTFYVKSSLS----PDD--QFLISGSSDEAAYIWKVSMPWHPPTVLLGHSQEVTSVCWCpsDFTKIATCSDDNT 322
Cdd:PLN00181  606 NQGVSIGTIKTKANICcvqfPSEsgRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV--DSSTLVSSSTDNT 683
                         170       180
                  ....*....|....*....|....*...
gi 1958674738 323 LKIWRLNRGLEEKPEGDKHSIVGWTSQK 350
Cdd:PLN00181  684 LKLWDLSMSISGINETPLHSFMGHTNVK 711
WD40 pfam00400
WD domain, G-beta repeat;
288-326 9.24e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 9.24e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958674738 288 WHPPTVLLGHSQEVTSVCWCPSDfTKIATCSDDNTLKIW 326
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-329 6.84e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.74  E-value: 6.84e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738   3 HILAVANEEGFVRLYNTESQTskktCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELMGTCKGHQCSLK 82
Cdd:COG2319   133 KTLASGSADGTVRLWDLATGK----LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVR 208
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738  83 SVAFSKFQKAVFcTGGRDGNIMIWDTrcnkkdgfyrqvnqisgahntadkqtpskpkkkQNSKGLAPSVDSQQSVTVVLF 162
Cdd:COG2319   209 SVAFSPDGKLLA-SGSADGTVRLWDL---------------------------------ATGKLLRTLTGHSGSVRSVAF 254
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 163 -QDENTVVSAGAvDGIIKVWDLRknytayrqepiasksflyPGTSTRKLGY-----SSLVLDSTGSTLFANCTDDNIYMF 236
Cdd:COG2319   255 sPDGRLLASGSA-DGTVRLWDLA------------------TGELLRTLTGhsggvNSVAFSPDGKLLASGSDDGTVRLW 315
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 237 NMTGLKtsPLAVFNGHQNSTFYVksSLSPDDQFLISGSSDEAAYIWKVSmPWHPPTVLLGHSQEVTSVCWCPsDFTKIAT 316
Cdd:COG2319   316 DLATGK--LLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTVRLWDLA-TGELLRTLTGHTGAVTSVAFSP-DGRTLAS 389
                         330
                  ....*....|...
gi 1958674738 317 CSDDNTLKIWRLN 329
Cdd:COG2319   390 GSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
3-327 1.66e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 138.62  E-value: 1.66e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738   3 HILAVANEEGFVRLYNTESQTSKKTCfkewMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELMGTCKGHQCSLK 82
Cdd:cd00200    22 KLLATGSGDGTIKVWDLETGELLRTL----KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVS 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738  83 SVAFSKFQKaVFCTGGRDGNIMIWDTRCNKkdgfyrQVNQISGaHNtadkqtpskpkkkqnskglapsvdsqQSVTVVLF 162
Cdd:cd00200    98 SVAFSPDGR-ILSSSSRDKTIKVWDVETGK------CLTTLRG-HT--------------------------DWVNSVAF 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 163 QDENTVVSAGAVDGIIKVWDLRKNYTAYRqepiasksflYPGtstRKLGYSSLVLDSTGSTLFANCTDDNIYMFNMTGLK 242
Cdd:cd00200   144 SPDGTFVASSSQDGTIKLWDLRTGKCVAT----------LTG---HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 243 TspLAVFNGHQNSTFYVksSLSPDDQFLISGSSDEAAYIWKVsMPWHPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNT 322
Cdd:cd00200   211 C--LGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVWDL-RTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGT 284

                  ....*
gi 1958674738 323 LKIWR 327
Cdd:cd00200   285 IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
3-333 3.33e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.96  E-value: 3.33e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738   3 HILAVANEEGFVRLYNTESqtskKTCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELMGTCKGHQCSLK 82
Cdd:COG2319    91 RLLASASADGTVRLWDLAT----GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVT 166
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738  83 SVAFSKFQKAVFcTGGRDGNIMIWDTRcnkkDGfyRQVNQISGahntadkqtpskpkkkqnskglapsvdSQQSVTVVLF 162
Cdd:COG2319   167 SVAFSPDGKLLA-SGSDDGTVRLWDLA----TG--KLLRTLTG---------------------------HTGAVRSVAF 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 163 -QDENTVVSAGAvDGIIKVWDLRknytayRQEPIASksflYPGTSTrklGYSSLVLDSTGSTLFANCTDDNIYMFNMTGL 241
Cdd:COG2319   213 sPDGKLLASGSA-DGTVRLWDLA------TGKLLRT----LTGHSG---SVRSVAFSPDGRLLASGSADGTVRLWDLATG 278
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 242 KtsPLAVFNGHQNSTFYVksSLSPDDQFLISGSSDEAAYIWKVSMPWhPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDN 321
Cdd:COG2319   279 E--LLRTLTGHSGGVNSV--AFSPDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFSP-DGKTLASGSDDG 352
                         330
                  ....*....|..
gi 1958674738 322 TLKIWRLNRGLE 333
Cdd:COG2319   353 TVRLWDLATGEL 364
WD40 COG2319
WD40 repeat [General function prediction only];
35-331 5.77e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.63  E-value: 5.77e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738  35 HWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELMGTCKGHQCSLKSVAFSKFQKAVFcTGGRDGNIMIWDTRcnkkD 114
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLA-SGSADGTVRLWDLA----T 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 115 GfyRQVNQISGaHntadkqtpskpkkkqnskglapsvdsQQSVTVVLF-QDENTVVSAGAvDGIIKVWDLRKNytayrqE 193
Cdd:COG2319   152 G--KLLRTLTG-H--------------------------SGAVTSVAFsPDGKLLASGSD-DGTVRLWDLATG------K 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 194 PIASksflYPGTSTRKlgySSLVLDSTGSTLFANCTDDNIYMFNMTGLKtsPLAVFNGHQNSTFYVksSLSPDDQFLISG 273
Cdd:COG2319   196 LLRT----LTGHTGAV---RSVAFSPDGKLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSV--AFSPDGRLLASG 264
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958674738 274 SSDEAAYIWKVSmPWHPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIWRLNRG 331
Cdd:COG2319   265 SADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATG 320
WD40 COG2319
WD40 repeat [General function prediction only];
34-331 1.73e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 1.73e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738  34 AHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELMGTCKGHQCSLKSVAFSkFQKAVFCTGGRDGNIMIWDTrcnkk 113
Cdd:COG2319    34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS-PDGRLLASASADGTVRLWDL----- 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 114 dgfyrqvnqisgahntadkqtpskpkkkQNSKGLAPSVDSQQSVTVVLF-QDENTVVSAGAvDGIIKVWDLRknytayRQ 192
Cdd:COG2319   108 ----------------------------ATGLLLRTLTGHTGAVRSVAFsPDGKTLASGSA-DGTVRLWDLA------TG 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 193 EPIASksflYPGTSTRklgYSSLVLDSTGSTLFANCTDDNIYMFNMTGLKtsPLAVFNGHQNStfyVKS-SLSPDDQFLI 271
Cdd:COG2319   153 KLLRT----LTGHSGA---VTSVAFSPDGKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGA---VRSvAFSPDGKLLA 220
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 272 SGSSDEAAYIWKVSmPWHPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIWRLNRG 331
Cdd:COG2319   221 SGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATG 278
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
70-331 2.43e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 2.43e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738  70 LMGTCKGHQCSLKSVAFSKFQKaVFCTGGRDGNIMIWDTrcNKKDGFYRQVNQISGAhntadkqtpskpkkkqnskglap 149
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDL--ETGELLRTLKGHTGPV----------------------- 54
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 150 svdsqqsVTVVLFQDENTVVSAGAvDGIIKVWDLRKNYTAYRQEpiasksflypgtstrklGYSSLVLD---STGSTLFA 226
Cdd:cd00200    55 -------RDVAASADGTYLASGSS-DKTIRLWDLETGECVRTLT-----------------GHTSYVSSvafSPDGRILS 109
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 227 NCTDDN-IYMFNMTglKTSPLAVFNGHQNStfyVKS-SLSPDDQFLISGSSDEAAYIWKVSmPWHPPTVLLGHSQEVTSV 304
Cdd:cd00200   110 SSSRDKtIKVWDVE--TGKCLTTLRGHTDW---VNSvAFSPDGTFVASSSQDGTIKLWDLR-TGKCVATLTGHTGEVNSV 183
                         250       260
                  ....*....|....*....|....*..
gi 1958674738 305 CWCPsDFTKIATCSDDNTLKIWRLNRG 331
Cdd:cd00200   184 AFSP-DGEKLLSSSSDGTIKLWDLSTG 209
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
287-326 3.87e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 3.87e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958674738  287 PWHPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIW 326
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
169-350 9.61e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.01  E-value: 9.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 169 VSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFlypgtstrklgysSLVLDSTGSTLFANCTDDNiymfnmtglKTSPLAV 248
Cdd:PLN00181  548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVW-------------SIDYSSADPTLLASGSDDG---------SVKLWSI 605
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 249 FNGHQNSTFYVKSSLS----PDD--QFLISGSSDEAAYIWKVSMPWHPPTVLLGHSQEVTSVCWCpsDFTKIATCSDDNT 322
Cdd:PLN00181  606 NQGVSIGTIKTKANICcvqfPSEsgRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV--DSSTLVSSSTDNT 683
                         170       180
                  ....*....|....*....|....*...
gi 1958674738 323 LKIWRLNRGLEEKPEGDKHSIVGWTSQK 350
Cdd:PLN00181  684 LKLWDLSMSISGINETPLHSFMGHTNVK 711
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
57-321 4.65e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.09  E-value: 4.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738  57 DQTAKFWDVKAGELMGTCKGHQCSLKSVAFSKFQKAVFCTGGRDGNIMIWDTRCNKKDGfyrqvnQISGAHNTADKQTPS 136
Cdd:PLN00181  554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIG------TIKTKANICCVQFPS 627
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 137 kpkkkqnskglapsvDSQQSVTVvlfqdentvvsaGAVDGIIKVWDLRKNytayrQEPIASksflypgtstrKLGYSSLV 216
Cdd:PLN00181  628 ---------------ESGRSLAF------------GSADHKVYYYDLRNP-----KLPLCT-----------MIGHSKTV 664
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674738 217 -----LDStgSTLFANCTDDNIYMFNM----TGLKTSPLAVFNGHQNSTFYVksSLSPDDQFLISGSSDEAAYIWKVSMP 287
Cdd:PLN00181  665 syvrfVDS--STLVSSSTDNTLKLWDLsmsiSGINETPLHSFMGHTNVKNFV--GLSVSDGYIATGSETNEVFVYHKAFP 740
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1958674738 288 WHPPTVLLGH------------SQEVTSVCWCPSDFTKIATCSDDN 321
Cdd:PLN00181  741 MPVLSYKFKTidpvsglevddaSQFISSVCWRGQSSTLVAANSTGN 786
WD40 pfam00400
WD domain, G-beta repeat;
288-326 9.24e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 9.24e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958674738 288 WHPPTVLLGHSQEVTSVCWCPSDfTKIATCSDDNTLKIW 326
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
293-335 1.82e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 1.82e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1958674738 293 VLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIWRLNRGLEEK 335
Cdd:cd00200     4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLR 45
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
68-107 8.31e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 8.31e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958674738   68 GELMGTCKGHQCSLKSVAFSKFQKaVFCTGGRDGNIMIWD 107
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
68-107 4.80e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 4.80e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958674738  68 GELMGTCKGHQCSLKSVAFSKFQKaVFCTGGRDGNIMIWD 107
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
25-64 3.82e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 3.82e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958674738   25 KKTCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWD 64
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
26-64 7.14e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 7.14e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958674738  26 KTCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWD 64
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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