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Conserved domains on  [gi|1958676820|ref|XP_038948187|]
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ankyrin repeat and SOCS box protein 3 isoform X3 [Rattus norvegicus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-314 4.40e-44

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 156.65  E-value: 4.40e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  34 VKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSENYIKTKtfeGFCALHLAVSQGHWKVTQILLEAG 113
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADAL---GALLLLAAALAGDLLVALLLLAAG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 114 ADPNTTTLEETTPLFLAVESGQIDVLKLLLQHGANVNgSHSMCGWNSLHQASFQGNAEAIKLLLKQGADRECQDDFGITP 193
Cdd:COG0666    78 ADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN-ARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 194 LFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSNGADPDLYCNEDNWqlPIHAAAQMGHRKT 273
Cdd:COG0666   157 LHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKT--ALDLAAENGNLEI 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1958676820 274 LDLLIPLTNRACDSGPDKVSPVYSAVFGGREECLETLLQNG 314
Cdd:COG0666   235 VKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-314 4.40e-44

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 156.65  E-value: 4.40e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  34 VKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSENYIKTKtfeGFCALHLAVSQGHWKVTQILLEAG 113
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADAL---GALLLLAAALAGDLLVALLLLAAG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 114 ADPNTTTLEETTPLFLAVESGQIDVLKLLLQHGANVNgSHSMCGWNSLHQASFQGNAEAIKLLLKQGADRECQDDFGITP 193
Cdd:COG0666    78 ADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN-ARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 194 LFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSNGADPDLYCNEDNWqlPIHAAAQMGHRKT 273
Cdd:COG0666   157 LHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKT--ALDLAAENGNLEI 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1958676820 274 LDLLIPLTNRACDSGPDKVSPVYSAVFGGREECLETLLQNG 314
Cdd:COG0666   235 VKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
Ank_2 pfam12796
Ankyrin repeats (3 copies);
161-251 8.00e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 89.40  E-value: 8.00e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 161 LHQASFQGNAEAIKLLLKQGADRECQDDFGITPLFVAAQYGKLESLSILISSgANVNCQaLDKATPLFIAAQEGHTKCVE 240
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLK-DNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|.
gi 1958676820 241 LLLSNGADPDL 251
Cdd:pfam12796  79 LLLEKGADINV 89
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 63-356 8.52e-18

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 85.40  E-value: 8.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  63 YHNAVECLQMLIHTDSseNYIKTKTFEGFCALHLAVSQGHWKVTQILLEAGADPNTTTLEETTPLFLAVESGQIDVLKLL 142
Cdd:PHA02874   10 YSGDIEAIEKIIKNKG--NCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 143 LQHGANVNGSHSMCGwnslhqasfqgNAEAIKLLLKQGADRECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALD 222
Cdd:PHA02874   88 IDNGVDTSILPIPCI-----------EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDN 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 223 KATPLFIAAQEGHTKCVELLLSNGADPDLycNEDNWQLPIHAAAQMGHRKTLDLLIPLTNRACDSGPDKVSPVYSAVFGG 302
Cdd:PHA02874  157 GCYPIHIAIKHNFFDIIKLLLEKGAYANV--KDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958676820 303 ReECLETLLQNGYSPDAQMclvfGFSSPLCMALQKDCEFSgVVNILLKYGAQLN 356
Cdd:PHA02874  235 R-SAIELLINNASINDQDI----DGSTPLHHAINPPCDID-IIDILLYHKADIS 282
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 53-245 7.68e-11

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 64.26  E-value: 7.68e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  53 RGW-MPIHEAAYHNAVECLQMLIHTDSSENYikTKTFEGFCALHLAVSQGHWKVTQILLEAGADPNTTTLEE-----TTP 126
Cdd:cd22192    15 RISeSPLLLAAKENDVQAIKKLLKCPSCDLF--QRGALGETALHVAALYDNLEAAVVLMEAAPELVNEPMTSdlyqgETA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 127 LFLAVESGQIDVLKLLLQHGANVN-----------GSHSMC--GWNSLHQASFQGNAEAIKLLLKQGADRECQDDFGITP 193
Cdd:cd22192    93 LHIAVVNQNLNLVRELIARGADVVspratgtffrpGPKNLIyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTV 172

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958676820 194 LFV-AAQYGKL---ESLSILISSGANVNCQALDKA------TPLFIAAQEGHTKCVELLLSN 245
Cdd:cd22192   173 LHIlVLQPNKTfacQMYDLILSYDKEDDLQPLDLVpnnqglTPFKLAAKEGNIVMFQHLVQK 234
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 222-251 2.77e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 2.77e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958676820  222 DKATPLFIAAQEGHTKCVELLLSNGADPDL 251
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 129-287 3.15e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.15  E-value: 3.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 129 LAVESGQIDVLKLLLQHGANVNgshsmCGWNSLHQAS--FQGNAEAIKLLLKQgADRE----------CQDDF--GITPL 194
Cdd:TIGR00870  59 AAIENENLELTELLLNLSCRGA-----VGDTLLHAISleYVDAVEAILLHLLA-AFRKsgplelandqYTSEFtpGITAL 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 195 FVAAQYGKLESLSILISSGANVNCQAldkatplfiaaqeghtKCVELLLSNGADpDLYCNEdnwqLPIHAAAQMGHRKTL 274
Cdd:TIGR00870 133 HLAAHRQNYEIVKLLLERGASVPARA----------------CGDFFVKSQGVD-SFYHGE----SPLNAAACLGSPSIV 191

                         170
                  ....*....|....*
gi 1958676820 275 DLLI--PLTNRACDS 287
Cdd:TIGR00870 192 ALLSedPADILTADS 206
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-314 4.40e-44

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 156.65  E-value: 4.40e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  34 VKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSENYIKTKtfeGFCALHLAVSQGHWKVTQILLEAG 113
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADAL---GALLLLAAALAGDLLVALLLLAAG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 114 ADPNTTTLEETTPLFLAVESGQIDVLKLLLQHGANVNgSHSMCGWNSLHQASFQGNAEAIKLLLKQGADRECQDDFGITP 193
Cdd:COG0666    78 ADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN-ARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 194 LFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSNGADPDLYCNEDNWqlPIHAAAQMGHRKT 273
Cdd:COG0666   157 LHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKT--ALDLAAENGNLEI 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1958676820 274 LDLLIPLTNRACDSGPDKVSPVYSAVFGGREECLETLLQNG 314
Cdd:COG0666   235 VKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
27-280 1.46e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 149.72  E-value: 1.46e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  27 LAAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHtdsSENYIKTKTFEGFCALHLAVSQGHWKVT 106
Cdd:COG0666    27 AAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLA---AGADINAKDDGGNTLLHAAARNGDLEIV 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 107 QILLEAGADPNTTTLEETTPLFLAVESGQIDVLKLLLQHGANVNGSHSMcGWNSLHQASFQGNAEAIKLLLKQGADRECQ 186
Cdd:COG0666   104 KLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNAR 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 187 DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSNGADPDLYCNEDNwqLPIHAAA 266
Cdd:COG0666   183 DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGL--TALLLAA 260

                         250
                  ....*....|....
gi 1958676820 267 QMGHRKTLDLLIPL 280
Cdd:COG0666   261 AAGAALIVKLLLLA 274
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
27-260 1.37e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 144.33  E-value: 1.37e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  27 LAAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSenyIKTKTFEGFCALHLAVSQGHWKVT 106
Cdd:COG0666    60 AAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD---VNARDKDGETPLHLAAYNGNLEIV 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 107 QILLEAGADPNTTTLEETTPLFLAVESGQIDVLKLLLQHGANVNGSHSMcGWNSLHQASFQGNAEAIKLLLKQGADRECQ 186
Cdd:COG0666   137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958676820 187 DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSNGADPDLYCNEDNWQL 260
Cdd:COG0666   216 DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
108-356 7.29e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 115.05  E-value: 7.29e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 108 ILLEAGADPNTTTLEETTPLFLAVESGQIDVLKLLLQHGANVNGSHSMCGWNSLHQASFQGNAEAIKLLLKQGADRECQD 187
Cdd:COG0666     5 LLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 188 DFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSNGADPDLYCNEDNwqLPIHAAAQ 267
Cdd:COG0666    85 DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGN--TPLHLAAA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 268 MGHRKTLDLLIpltnracDSGPD-------KVSPVYSAVFGGREECLETLLQNGYSPDAQMCLvfgFSSPLCMALQKDCE 340
Cdd:COG0666   163 NGNLEIVKLLL-------EAGADvnardndGETPLHLAAENGHLEIVKLLLEAGADVNAKDND---GKTALDLAAENGNL 232

                         250
                  ....*....|....*.
gi 1958676820 341 fsGVVNILLKYGAQLN 356
Cdd:COG0666   233 --EIVKLLLEAGADLN 246
Ank_2 pfam12796
Ankyrin repeats (3 copies);
161-251 8.00e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 89.40  E-value: 8.00e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 161 LHQASFQGNAEAIKLLLKQGADRECQDDFGITPLFVAAQYGKLESLSILISSgANVNCQaLDKATPLFIAAQEGHTKCVE 240
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLK-DNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|.
gi 1958676820 241 LLLSNGADPDL 251
Cdd:pfam12796  79 LLLEKGADINV 89
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
139-356 8.35e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 95.41  E-value: 8.35e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 139 LKLLLQHGANVNGSHSMCGWNSLHQASFQGNAEAIKLLLKQGADRECQDDFGITPLFVAAQYGKLESLSILISSGANVNC 218
Cdd:COG0666     3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 219 QALDKATPLFIAAQEGHTKCVELLLSNGADPDLYCNEDNWqlPIHAAAQMGHRKTLDLLIpltnracDSGPD-------K 291
Cdd:COG0666    83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGET--PLHLAAYNGNLEIVKLLL-------EAGADvnaqdndG 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958676820 292 VSPVYSAVFGGREECLETLLQNGYSPDAQmcLVFGFsSPLCMALQKDCEfsGVVNILLKYGAQLN 356
Cdd:COG0666   154 NTPLHLAAANGNLEIVKLLLEAGADVNAR--DNDGE-TPLHLAAENGHL--EIVKLLLEAGADVN 213
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 63-356 8.52e-18

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 85.40  E-value: 8.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  63 YHNAVECLQMLIHTDSseNYIKTKTFEGFCALHLAVSQGHWKVTQILLEAGADPNTTTLEETTPLFLAVESGQIDVLKLL 142
Cdd:PHA02874   10 YSGDIEAIEKIIKNKG--NCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 143 LQHGANVNGSHSMCGwnslhqasfqgNAEAIKLLLKQGADRECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALD 222
Cdd:PHA02874   88 IDNGVDTSILPIPCI-----------EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDN 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 223 KATPLFIAAQEGHTKCVELLLSNGADPDLycNEDNWQLPIHAAAQMGHRKTLDLLIPLTNRACDSGPDKVSPVYSAVFGG 302
Cdd:PHA02874  157 GCYPIHIAIKHNFFDIIKLLLEKGAYANV--KDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958676820 303 ReECLETLLQNGYSPDAQMclvfGFSSPLCMALQKDCEFSgVVNILLKYGAQLN 356
Cdd:PHA02874  235 R-SAIELLINNASINDQDI----DGSTPLHHAINPPCDID-IIDILLYHKADIS 282
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 32-299 3.65e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 83.47  E-value: 3.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  32 GNVKILRKLLK-KGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSENYIKTKTFEgfcALHLAVSQGHWKVTQILL 110
Cdd:PHA02874   12 GDIEAIEKIIKnKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPH---PLLTAIKIGAHDIIKLLI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 111 EAGADPNtttleettplFLAVESGQIDVLKLLLQHGANVNGSHSMCGwNSLHQASFQGNAEAIKLLLKQGADRECQDDFG 190
Cdd:PHA02874   89 DNGVDTS----------ILPIPCIEKDMIKTILDCGIDVNIKDAELK-TFLHYAIKKGDLESIKMLFEYGADVNIEDDNG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 191 ITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSNGADPDLYCNedNWQLPIHAAAqMGH 270
Cdd:PHA02874  158 CYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCK--NGFTPLHNAI-IHN 234

                         250       260       270
                  ....*....|....*....|....*....|
gi 1958676820 271 RKTLDLLIplTNRAC-DSGPDKVSPVYSAV 299
Cdd:PHA02874  235 RSAIELLI--NNASInDQDIDGSTPLHHAI 262
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-248 2.19e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 80.86  E-value: 2.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  33 NVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSsenYIKTKTFEGFCALHLAVSQGH-----WKVTQ 107
Cdd:PHA03100   14 KVKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGA---DINSSTKNNSTPLHYLSNIKYnltdvKEIVK 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 108 ILLEAGADPNTTTLEETTPLFLAV--ESGQIDVLKLLLQHGANVNgSHSMCGWNSLHQASFQGNAE-------------- 171
Cdd:PHA03100   91 LLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVN-IKNSDGENLLHLYLESNKIDlkilkllidkgvdi 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 172 ----AIKLLLKQGADRECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSNGA 247
Cdd:PHA03100  170 naknRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249


                  .
gi 1958676820 248 D 248
Cdd:PHA03100  250 S 250
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 32-251 3.97e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 80.04  E-value: 3.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  32 GNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSENYiKTKTFEGfcALHLAVSQGHWKVTQILLE 111
Cdd:PHA02875   13 GELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDV-KYPDIES--ELHDAVEEGDVKAVEELLD 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 112 AGADPNTTTLEETTP-LFLAVESGQIDVLKLLLQHGANVNGShSMCGWNSLHQASFQGNAEAIKLLLKQGADRECQDDFG 190
Cdd:PHA02875   90 LGKFADDVFYKDGMTpLHLATILKKLDIMKLLIARGADPDIP-NTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCG 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958676820 191 ITPLFVAAQYGKLESLSILISSGANVNCQALDK-ATPLFIAAQEGHTKCVELLLSNGADPDL 251
Cdd:PHA02875  169 CTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGADCNI 230
Ank_2 pfam12796
Ankyrin repeats (3 copies);
128-219 8.93e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.46  E-value: 8.93e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 128 FLAVESGQIDVLKLLLQHGANVNgSHSMCGWNSLHQASFQGNAEAIKLLLKQgADRECQDDfGITPLFVAAQYGKLESLS 207
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADAN-LQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 1958676820 208 ILISSGANVNCQ 219
Cdd:pfam12796  79 LLLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
194-278 1.25e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.07  E-value: 1.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 194 LFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSNgADPDLYCNEDNwqlPIHAAAQMGHRKT 273
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT---ALHYAARSGHLEI 76


                  ....*
gi 1958676820 274 LDLLI 278
Cdd:pfam12796  77 VKLLL 81
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 128-373 4.53e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 77.01  E-value: 4.53e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 128 FLAVESGQIDVLKLLLQHGANVNgSHSMCGWNSLHQASFQG-----NAEAIKLLLKQGADRECQDDFGITPLFVAAQyGK 202
Cdd:PHA03100   40 YLAKEARNIDVVKILLDNGADIN-SSTKNNSTPLHYLSNIKynltdVKEIVKLLLEYGANVNAPDNNGITPLLYAIS-KK 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 203 LESLSI---LISSGANVNCQALDKATPLFIAAQEGH--TKCVELLLSNGADPDLYCNED---NWQLPIHAAAQMGHrktl 274
Cdd:PHA03100  118 SNSYSIveyLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINAKNRVNyllSYGVPINIKDVYGF---- 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 275 dllipltnracdsgpdkvSPVYSAVFGGREECLETLLQNGYSPDAqmCLVFGfSSPLCMALQKdcEFSGVVNILLKYGAq 354
Cdd:PHA03100  194 ------------------TPLHYAVYNNNPEFVKYLLDLGANPNL--VNKYG-DTPLHIAILN--NNKEIFKLLLNNGP- 249

                         250
                  ....*....|....*....
gi 1958676820 355 lNELHLAYCLKYEKFSMFC 373
Cdd:PHA03100  250 -SIKTIIETLLYFKDKDLN 267
Ank_2 pfam12796
Ankyrin repeats (3 copies);
27-115 1.25e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.37  E-value: 1.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  27 LAAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIhtdssENYIKTKTFEGFCALHLAVSQGHWKVT 106
Cdd:pfam12796   3 LAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-----EHADVNLKDNGRTALHYAARSGHLEIV 77


                  ....*....
gi 1958676820 107 QILLEAGAD 115
Cdd:pfam12796  78 KLLLEKGAD 86
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-217 9.45e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 72.78  E-value: 9.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  33 NVKILRKLLKKGRSVDVADNRGWMPIHEAAYH--NAVECLQMLIHTDSSenyIKTKTFEGFCALHLAVSQGHW--KVTQI 108
Cdd:PHA03100   85 VKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGAN---VNIKNSDGENLLHLYLESNKIdlKILKL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 109 LLEAGADPntttleettplflavesGQIDVLKLLLQHGANVNgSHSMCGWNSLHQASFQGNAEAIKLLLKQGADRECQDD 188
Cdd:PHA03100  162 LIDKGVDI-----------------NAKNRVNYLLSYGVPIN-IKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNK 223

                         170       180
                  ....*....|....*....|....*....
gi 1958676820 189 FGITPLFVAAQYGKLESLSILISSGANVN 217
Cdd:PHA03100  224 YGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
Ank_2 pfam12796
Ankyrin repeats (3 copies);
227-320 9.78e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.68  E-value: 9.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 227 LFIAAQEGHTKCVELLLSNGADPDlyCNEDNWQLPIHAAAQMGHRKTLDLLIPltNRACDSGPDKVSPVYSAVFGGREEC 306
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADAN--LQDKNGRTALHLAAKNGHLEIVKLLLE--HADVNLKDNGRTALHYAARSGHLEI 76

                          90
                  ....*....|....
gi 1958676820 307 LETLLQNGYSPDAQ 320
Cdd:pfam12796  77 VKLLLEKGADINVK 90
PHA03095 PHA03095
ankyrin-like protein; Provisional
 2-257 9.83e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.14  E-value: 9.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820   2 VTTVSTLIKK---MDFTEAYSDTCSTVGLAAREGNVK-ILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVE-CLQMLIHT 76
Cdd:PHA03095   27 VEEVRRLLAAgadVNFRGEYGKTPLHLYLHYSSEKVKdIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLdVIKLLIKA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  77 DSSENYiktKTFEGFCALH--LAVSQGHWKVTQILLEAGADPNTTTLEETTPLFLAVESGQIDV--LKLLLQHGANVNGS 152
Cdd:PHA03095  107 GADVNA---KDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVelLRLLIDAGADVYAV 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 153 hSMCGWNSLHQ--ASFQGNAEAIKLLLKQGADRECQDDFGITPLFVAAQYGKLESLSI--LISSGANVNCQALDKATPLF 228
Cdd:PHA03095  184 -DDRFRSLLHHhlQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLH 262

                         250       260
                  ....*....|....*....|....*....
gi 1958676820 229 IAAQEGHTKCVELLLSNGADPDLYCNEDN 257
Cdd:PHA03095  263 YAAVFNNPRACRRLIALGADINAVSSDGN 291
Ank_2 pfam12796
Ankyrin repeats (3 copies);
94-182 2.05e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.91  E-value: 2.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  94 LHLAVSQGHWKVTQILLEAGADPNTTTLEETTPLFLAVESGQIDVLKLLLQHganVNGSHSMCGWNSLHQASFQGNAEAI 173
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEIV 77


                  ....*....
gi 1958676820 174 KLLLKQGAD 182
Cdd:pfam12796  78 KLLLEKGAD 86
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 94-357 2.58e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 68.94  E-value: 2.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  94 LHLAVSQGHWKVTQILLEAGADPNTTTLEETTPLFLAVESGQIDVLKLLLQHGANVNGSHSmcgwnSLHQASFQGNAEAI 173
Cdd:PHA02876  182 IHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDL-----SLLKAIRNEDLETS 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 174 KLLLKQGADRECQDDFGITPLFVAAQYGKLESL-SILISSGANVNCQALDKATPLFIAAQEGH-TKCVELLLSNGADPDl 251
Cdd:PHA02876  257 LLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVN- 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 252 yCNEDNWQLPIHAAAQMGHRKtlDLLIPLTNRA--------CDSGPDKVSPVYSAV--------FGGREECL-------- 307
Cdd:PHA02876  336 -AADRLYITPLHQASTLDRNK--DIVITLLELGanvnardyCDKTPIHYAAVRNNVviintlldYGADIEALsqkigtal 412

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 308 -------------ETLLQNGYSPDAQMCLVfgfSSPLCMALQKDC------------------------------EFSGV 344
Cdd:PHA02876  413 hfalcgtnpymsvKTLIDRGANVNSKNKDL---STPLHYACKKNCkldviemlldngadvnainiqnqypllialEYHGI 489

                         330
                  ....*....|...
gi 1958676820 345 VNILLKYGAQLNE 357
Cdd:PHA02876  490 VNILLHYGAELRD 502
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 9-248 6.15e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 67.60  E-value: 6.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820   9 IKKMDFTEAYSDTCSTVGL-----AAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTdssenYI 83
Cdd:PHA02878   20 IEYIDHTENYSTSASLIPFiplhqAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRS-----IN 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  84 KTKTFEGFCALHLAVSQGHWKVTQILLEAGADPNTTTLEETTPLFLAVESGQIDVLKLLLQHGANVNGSHSMCGWNSLHQ 163
Cdd:PHA02878   95 KCSVFYTLVAIKDAFNNRNVEIFKIILTNRYKNIQTIDLVYIDKKSKDDIIEAEITKLLLSYGADINMKDRHKGNTALHY 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 164 ASFQGNAEAIKLLLKQGADRECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAqeGHTKCVE--- 240
Cdd:PHA02878  175 ATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV--GYCKDYDilk 252


                  ....*...
gi 1958676820 241 LLLSNGAD 248
Cdd:PHA02878  253 LLLEHGVD 260
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 28-222 2.77e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 66.04  E-value: 2.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  28 AAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSenyIKTKTFEGFCALHLAVSQGHWKVTQ 107
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACN---VHIRDANGNTALWNAISAKHHKIFR 608

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 108 IlleagadpntttleettplflavesgqidvlkllLQHGANVNGSHSmcGWNSLHQASFQGNAEAIKLLLKQGADRECQD 187
Cdd:PLN03192  609 I----------------------------------LYHFASISDPHA--AGDLLCTAAKRNDLTAMKELLKQGLNVDSED 652

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1958676820 188 DFGITPLFVAAQYGKLESLSILISSGANVNCQALD 222
Cdd:PLN03192  653 HQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 35-245 3.51e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 64.90  E-value: 3.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  35 KILRKLLKKGRSVDVAD-NRGWMPIHEAAYHNAVECLQMLIHTDSSENyIKTKTFEGfcALHLAVSQGHWKVTQILLEAG 113
Cdd:PHA02878  148 EITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVN-IPDKTNNS--PLHHAVKHYNKPIVHILLENG 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 114 ADPNTTTLEETTPLFLAVES-GQIDVLKLLLQHGANVNGSHSMCGWNSLHQASfqGNAEAIKLLLKQGADRECQDDFGIT 192
Cdd:PHA02878  225 ASTDARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYILGLTALHSSI--KSERKLKLLLEYGADINSLNSYKLT 302

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958676820 193 PLFVAA-QYGKLESLSILISsgaNVNCQALDKAtplFIAAQEGHTKCVELLLSN 245
Cdd:PHA02878  303 PLSSAVkQYLCINIGRILIS---NICLLKRIKP---DIKNSEGFIDNMDCITSN 350
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 53-245 7.68e-11

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 64.26  E-value: 7.68e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  53 RGW-MPIHEAAYHNAVECLQMLIHTDSSENYikTKTFEGFCALHLAVSQGHWKVTQILLEAGADPNTTTLEE-----TTP 126
Cdd:cd22192    15 RISeSPLLLAAKENDVQAIKKLLKCPSCDLF--QRGALGETALHVAALYDNLEAAVVLMEAAPELVNEPMTSdlyqgETA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 127 LFLAVESGQIDVLKLLLQHGANVN-----------GSHSMC--GWNSLHQASFQGNAEAIKLLLKQGADRECQDDFGITP 193
Cdd:cd22192    93 LHIAVVNQNLNLVRELIARGADVVspratgtffrpGPKNLIyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTV 172

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958676820 194 LFV-AAQYGKL---ESLSILISSGANVNCQALDKA------TPLFIAAQEGHTKCVELLLSN 245
Cdd:cd22192   173 LHIlVLQPNKTfacQMYDLILSYDKEDDLQPLDLVpnnqglTPFKLAAKEGNIVMFQHLVQK 234
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 173-402 1.05e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 60.06  E-value: 1.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 173 IKLLLKQGADRECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHT-----KCVELLLSNGA 247
Cdd:PHA03100   18 IKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 248 DPDLYCNEDNWQLPIHAAAQMGHRKTLDLLIpltNRACD---SGPDKVSPVYSAVFGGRE--ECLETLLQNGYSPDAqmc 322
Cdd:PHA03100   98 NVNAPDNNGITPLLYAISKKSNSYSIVEYLL---DNGANvniKNSDGENLLHLYLESNKIdlKILKLLIDKGVDINA--- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 323 lvfgfssplcmalqKDcefsgVVNILLKYGAQLNE--------LHLAycLKYEKFSMFCCFLKKGCLVvpwNHTSEF--- 391
Cdd:PHA03100  172 --------------KN-----RVNYLLSYGVPINIkdvygftpLHYA--VYNNNPEFVKYLLDLGANP---NLVNKYgdt 227

                         250
                  ....*....|..
gi 1958676820 392 -VSYAVKAQTKY 402
Cdd:PHA03100  228 pLHIAILNNNKE 239
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 28-248 1.97e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 56.61  E-value: 1.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  28 AAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSEN--------YIKTKTFE--------GF 91
Cdd:PHA02876  185 AAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINkndlsllkAIRNEDLEtslllydaGF 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  92 CA----------LHLAVSQGHW-KVTQILLEAGADPNTTTLEETTPLFLAVESG-QIDVLKLLLQHGANVNGSHSMcgWN 159
Cdd:PHA02876  265 SVnsiddckntpLHHASQAPSLsRLVPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRL--YI 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 160 S-LHQAS-FQGNAEAIKLLLKQGADRECQDDFGITPLFVAA------------QYG-KLESLS----------------- 207
Cdd:PHA02876  343 TpLHQAStLDRNKDIVITLLELGANVNARDYCDKTPIHYAAvrnnvviintllDYGaDIEALSqkigtalhfalcgtnpy 422

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1958676820 208 ----ILISSGANVNCQALDKATPLFIAAQEG-HTKCVELLLSNGAD 248
Cdd:PHA02876  423 msvkTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGAD 468
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 208-318 2.48e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 56.45  E-value: 2.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 208 ILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSNGADPDLYCNEDNwqLPIHAAAQMGHRKTLDLLipLTNRACDS 287
Cdd:PTZ00322  100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGK--TPLELAEENGFREVVQLL--SRHSQCHF 175

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958676820 288 GPDKVSPVYSavFGGREECLETLLQNGYSPD 318
Cdd:PTZ00322  176 ELGANAKPDS--FTGKPPSLEDSPISSHHPD 204
Ank_4 pfam13637
Ankyrin repeats (many copies);
192-243 2.69e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.97  E-value: 2.69e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958676820 192 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLL 243
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 28-200 8.88e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.20  E-value: 8.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  28 AAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSsenYIKTKTFEGFCALHLAVSQGHWKVTQ 107
Cdd:PHA02874  131 AIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGA---YANVKDNNGESPLHNAAEYGDYACIK 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 108 ILLEAGADPNTTTLEETTPLFLAVESGQiDVLKLLLQHgANVNgSHSMCGWNSLHQA-SFQGNAEAIKLLLKQGADRECQ 186
Cdd:PHA02874  208 LLIDHGNHIMNKCKNGFTPLHNAIIHNR-SAIELLINN-ASIN-DQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIK 284

                         170
                  ....*....|....
gi 1958676820 187 DDFGITPLFVAAQY 200
Cdd:PHA02874  285 DNKGENPIDTAFKY 298
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 161-244 9.56e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.52  E-value: 9.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 161 LHQASFQGNAEAIKLLLKQGADRECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVE 240
Cdd:PTZ00322   86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165


                  ....
gi 1958676820 241 LLLS 244
Cdd:PTZ00322  166 LLSR 169
Ank_4 pfam13637
Ankyrin repeats (many copies);
225-278 1.20e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.04  E-value: 1.20e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958676820 225 TPLFIAAQEGHTKCVELLLSNGADPDlYCNEDNWQlPIHAAAQMGHRKTLDLLI 278
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADIN-AVDGNGET-ALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
28-74 1.71e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.65  E-value: 1.71e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958676820  28 AAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLI 74
Cdd:pfam13637   8 AAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 174-356 1.79e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.53  E-value: 1.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 174 KLLLKQGADRECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSNGA------ 247
Cdd:PHA02876  162 EMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSninknd 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 248 --------DPDLYCN-------------EDNWQLPIHAAAQMghrKTLDLLIP-LTNRACDSGPDKV---SPVYSAVFGG 302
Cdd:PHA02876  242 lsllkairNEDLETSlllydagfsvnsiDDCKNTPLHHASQA---PSLSRLVPkLLERGADVNAKNIkgeTPLYLMAKNG 318

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958676820 303 RE-ECLETLLQNGYSPDAQMCLvfgFSSPLCMALQKDcEFSGVVNILLKYGAQLN 356
Cdd:PHA02876  319 YDtENIRTLIMLGADVNAADRL---YITPLHQASTLD-RNKDIVITLLELGANVN 369
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 171-255 2.02e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 52.68  E-value: 2.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 171 EAIKLLLKQGADRECQDDFG----ITPLFVAAQYGKLESLSILISSGANVNCQALD-KATPLFIAAQEGHTKCVELLLSN 245
Cdd:PHA02884   47 DIIDAILKLGADPEAPFPLSenskTNPLIYAIDCDNDDAAKLLIRYGADVNRYAEEaKITPLYISVLHGCLKCLEILLSY 126

                          90
                  ....*....|
gi 1958676820 246 GADPDLYCNE 255
Cdd:PHA02884  127 GADINIQTND 136
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 137-230 2.53e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 52.29  E-value: 2.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 137 DVLKLLLQHGANVNGSHSM---CGWNSLHQASFQGNAEAIKLLLKQGAD-RECQDDFGITPLFVAAQYGKLESLSILISS 212
Cdd:PHA02884   47 DIIDAILKLGADPEAPFPLsenSKTNPLIYAIDCDNDDAAKLLIRYGADvNRYAEEAKITPLYISVLHGCLKCLEILLSY 126

                          90
                  ....*....|....*...
gi 1958676820 213 GANVNCQALDKATPLFIA 230
Cdd:PHA02884  127 GADINIQTNDMVTPIELA 144
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 35-248 2.98e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 52.76  E-value: 2.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  35 KILRKLLKKGRSVDVADNRGWMPIHEAAYHN-AVECLQMLIHTDSSENYIKTKTFEgfcALHLAVSQGHWKVTQI-LLEA 112
Cdd:PHA02876  288 RLVPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYIT---PLHQASTLDRNKDIVItLLEL 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 113 GADPNTTTLEETTPLFLAVESGQIDVLKLLLQHGANVNGSHSMCGwNSLHQASFQGNA-EAIKLLLKQGADRECQDDFGI 191
Cdd:PHA02876  365 GANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIG-TALHFALCGTNPyMSVKTLIDRGANVNSKNKDLS 443

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958676820 192 TPLFVAAQYG-KLESLSILISSGANVNCQALDKATPLFIAAqeGHTKCVELLLSNGAD 248
Cdd:PHA02876  444 TPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGAE 499
PHA03095 PHA03095
ankyrin-like protein; Provisional
 170-380 3.91e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 52.33  E-value: 3.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 170 AEAIKLLLKQGADRECQDDFGITPLFVAAQYGK---LESLSILISSGANVNCQALDKATPLFIAAQEGHT-KCVELLLSN 245
Cdd:PHA03095   27 VEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKLLIKA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 246 GADPDLYCNEDNWQLPIHAAAQMGHRKTLDLLI---------------PLT----NRACDSGP-----DKVSPVYSAVFG 301
Cdd:PHA03095  107 GADVNAKDKVGRTPLHVYLSGFNINPKVIRLLLrkgadvnaldlygmtPLAvllkSRNANVELlrlliDAGADVYAVDDR 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 302 G-------------REECLETLLQNGYSPDAQMclVFGFSSPLCMALQKDCEFSGVVNILLKyGAQLNE--------LHL 360
Cdd:PHA03095  187 FrsllhhhlqsfkpRARIVRELIRAGCDPAATD--MLGNTPLHSMATGSSCKRSLVLPLLIA-GISINArnrygqtpLHY 263

                         250       260
                  ....*....|....*....|
gi 1958676820 361 AYClkYEKFSMFCCFLKKGC 380
Cdd:PHA03095  264 AAV--FNNPRACRRLIALGA 281
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 18-150 5.11e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.92  E-value: 5.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  18 YSDTCSTVGLAAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIH----TDSSENYiktktfeGFCA 93
Cdd:PHA02875   99 YKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDhkacLDIEDCC-------GCTP 171

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958676820  94 LHLAVSQGHWKVTQILLEAGADPNTTTLEETTPLF-LAVESGQIDVLKLLLQHGANVN 150
Cdd:PHA02875  172 LIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALcYAIENNKIDIVRLFIKRGADCN 229
Ank_4 pfam13637
Ankyrin repeats (many copies);
128-177 1.06e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.34  E-value: 1.06e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958676820 128 FLAVESGQIDVLKLLLQHGANVNGSHSmCGWNSLHQASFQGNAEAIKLLL 177
Cdd:pfam13637   6 HAAAASGHLELLRLLLEKGADINAVDG-NGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 197-356 5.63e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.45  E-value: 5.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 197 AAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSNGADPDLycNEDNWQLPIHAAAQMGHRKTLDL 276
Cdd:PHA02875    9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDV--KYPDIESELHDAVEEGDVKAVEE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 277 LIPLTNRACDS-GPDKVSPVYSAVFGGREECLETLLQNGYSPDAQMCLVFgfsSPLCMA-LQKDCEfsgVVNILLKYGAQ 354
Cdd:PHA02875   87 LLDLGKFADDVfYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKF---SPLHLAvMMGDIK---GIELLIDHKAC 160


                  ..
gi 1958676820 355 LN 356
Cdd:PHA02875  161 LD 162
Ank_4 pfam13637
Ankyrin repeats (many copies);
157-210 6.28e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.42  E-value: 6.28e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958676820 157 GWNSLHQASFQGNAEAIKLLLKQGADRECQDDFGITPLFVAAQYGKLESLSILI 210
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02798 PHA02798
ankyrin-like protein; Provisional
 128-255 8.56e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 47.91  E-value: 8.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 128 FLAVESGQIDVLKLLLQHGANVNG-----SHSMCGWNSlHQASFQGNAEAIKLLLKQGADRECQDDFGITPLFVAAQYG- 201
Cdd:PHA02798   43 YLQRDSPSTDIVKLFINLGANVNGldneySTPLCTILS-NIKDYKHMLDIVKILIENGADINKKNSDGETPLYCLLSNGy 121

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958676820 202 --KLESLSILISSGANVNCQALDKATPLFIAAQEGHT---KCVELLLSNGADPDLYCNE 255
Cdd:PHA02798  122 inNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHidiEIIKLLLEKGVDINTHNNK 180
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
203-361 1.77e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.49  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 203 LESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSNGADPDLycNEDNWQLPIHAAAQMGHRKTLDLLIPLTN 282
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALAL--ADALGALLLLAAALAGDLLVALLLLAAGA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 283 RACDSGPDKVSPVYSAVFGGREECLETLLQNGYSPDAQMclvFGFSSPLCMALQKDCEfsGVVNILLKYGAQLNE----- 357
Cdd:COG0666    79 DINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARD---KDGETPLHLAAYNGNL--EIVKLLLEAGADVNAqdndg 153


                  ....*..
gi 1958676820 358 ---LHLA 361
Cdd:COG0666   154 ntpLHLA 160
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 128-317 2.73e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 46.54  E-value: 2.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 128 FLAVESGQIDVLK-LLLQHGANV--NGSHsmcGWNSLHQASFQGNAEAIKLLLKqgADRE-----CQDDF--GITPLFVA 197
Cdd:cd22192    22 LLAAKENDVQAIKkLLKCPSCDLfqRGAL---GETALHVAALYDNLEAAVVLME--AAPElvnepMTSDLyqGETALHIA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 198 AQYGKLESLSILISSGANVncqALDKAT-----------------PLFIAAQEGHTKCVELLLSNGADPDlycNEDNW-Q 259
Cdd:cd22192    97 VVNQNLNLVRELIARGADV---VSPRATgtffrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIR---AQDSLgN 170

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958676820 260 LPIHAAAqmghrktldlLIPLTNRACDsgpdkvspVY----SAVFGGREECLETLLQN-GYSP 317
Cdd:cd22192   171 TVLHILV----------LQPNKTFACQ--------MYdlilSYDKEDDLQPLDLVPNNqGLTP 215
PHA03095 PHA03095
ankyrin-like protein; Provisional
 33-194 6.95e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.02  E-value: 6.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  33 NVKILRKLLKKGRSVDVADNRGWMPIHeaAY---HNA-VECLQMLIHTDSsenYIKTKTFEGFCALH-LAVS-QGHWKVT 106
Cdd:PHA03095  131 NPKVIRLLLRKGADVNALDLYGMTPLA--VLlksRNAnVELLRLLIDAGA---DVYAVDDRFRSLLHhHLQSfKPRARIV 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 107 QILLEAGADPNTTTLEETTPLFLAVESG---QIDVLKLLLqHGANVNGSHSMcGWNSLHQASFQGNAEAIKLLLKQGADR 183
Cdd:PHA03095  206 RELIRAGCDPAATDMLGNTPLHSMATGSsckRSLVLPLLI-AGISINARNRY-GQTPLHYAAVFNNPRACRRLIALGADI 283

                         170
                  ....*....|.
gi 1958676820 184 ECQDDFGITPL 194
Cdd:PHA03095  284 NAVSSDGNTPL 294
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 225-251 2.54e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.42  E-value: 2.54e-04
                          10        20
                  ....*....|....*....|....*...
gi 1958676820 225 TPLFIAA-QEGHTKCVELLLSNGADPDL 251
Cdd:pfam00023   4 TPLHLAAgRRGNLEIVKLLLSKGADVNA 31
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 222-251 2.77e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 2.77e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958676820  222 DKATPLFIAAQEGHTKCVELLLSNGADPDL 251
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 129-287 3.15e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.15  E-value: 3.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 129 LAVESGQIDVLKLLLQHGANVNgshsmCGWNSLHQAS--FQGNAEAIKLLLKQgADRE----------CQDDF--GITPL 194
Cdd:TIGR00870  59 AAIENENLELTELLLNLSCRGA-----VGDTLLHAISleYVDAVEAILLHLLA-AFRKsgplelandqYTSEFtpGITAL 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 195 FVAAQYGKLESLSILISSGANVNCQAldkatplfiaaqeghtKCVELLLSNGADpDLYCNEdnwqLPIHAAAQMGHRKTL 274
Cdd:TIGR00870 133 HLAAHRQNYEIVKLLLERGASVPARA----------------CGDFFVKSQGVD-SFYHGE----SPLNAAACLGSPSIV 191

                         170
                  ....*....|....*
gi 1958676820 275 DLLI--PLTNRACDS 287
Cdd:TIGR00870 192 ALLSedPADILTADS 206
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 22-98 3.95e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 42.64  E-value: 3.95e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958676820  22 CSTVGLAAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIhtdSSENYIKTKTFEGFCALHLAV 98
Cdd:PHA02874  158 CYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLI---DHGNHIMNKCKNGFTPLHNAI 231
Ank_5 pfam13857
Ankyrin repeats (many copies);
142-194 7.91e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.33  E-value: 7.91e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958676820 142 LLQHG-ANVNGSHSmCGWNSLHQASFQGNAEAIKLLLKQGADRECQDDFGITPL 194
Cdd:pfam13857   1 LLEHGpIDLNRLDG-EGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 88-145 1.07e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.42  E-value: 1.07e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958676820  88 FEGFCALHLAVSQGHWKVTQILLEAGADPNTTTLEETTPLFLAVESGQIDVLKLLLQH 145
Cdd:PTZ00322  113 YDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
PHA02798 PHA02798
ankyrin-like protein; Provisional
 34-230 1.39e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.97  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  34 VKILRKLLKKGRSVDVADNRGWMPI-----HEAAYHNAVECLQMLIHTDSSenyIKTKTFEGFCALHLAVSQGHWKVTQI 108
Cdd:PHA02798   51 TDIVKLFINLGANVNGLDNEYSTPLctilsNIKDYKHMLDIVKILIENGAD---INKKNSDGETPLYCLLSNGYINNLEI 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 109 LL---EAGADPNTTTLEETTPLFLAVESG---QIDVLKLLLQHGANVNGSHSMCGWNSLHqASFQGN-----AEAIKLLL 177
Cdd:PHA02798  128 LLfmiENGADTTLLDKDGFTMLQVYLQSNhhiDIEIIKLLLEKGVDINTHNNKEKYDTLH-CYFKYNidridADILKLFV 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 178 KQG---------------------------------------ADRECQDDFGITPLFVAAQYGKLESLSILISSGANVNC 218
Cdd:PHA02798  207 DNGfiinkenkshkkkfmeylnsllydnkrfkknildfifsyIDINQVDELGFNPLYYSVSHNNRKIFEYLLQLGGDINI 286

                         250
                  ....*....|..
gi 1958676820 219 QALDKATPLFIA 230
Cdd:PHA02798  287 ITELGNTCLFTA 298
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 3-150 1.72e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.80  E-value: 1.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820   3 TTVSTLIKK-MDFTEAYSDTCSTVGLAAR--EGNVKILRKLLKKGRSVDVADNrgwmpiheaayhnaVECL-QMLIHTDS 78
Cdd:PHA03100  122 SIVEYLLDNgANVNIKNSDGENLLHLYLEsnKIDLKILKLLIDKGVDINAKNR--------------VNYLlSYGVPINI 187

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958676820  79 SENYiktktfeGFCALHLAVSQGHWKVTQILLEAGADPNTTTLEETTPLFLAVESGQIDVLKLLLQHGANVN 150
Cdd:PHA03100  188 KDVY-------GFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 190-218 2.53e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 2.53e-03
                           10        20
                   ....*....|....*....|....*....
gi 1958676820  190 GITPLFVAAQYGKLESLSILISSGANVNC 218
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 104-217 2.58e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 40.11  E-value: 2.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 104 KVTQILLEAGADPNTTTLEETTPLFLAVESGQI---DVLKLLLQHGANVNGSHSMCGWNSLHQ--ASFQGNAEAIKLLLK 178
Cdd:PHA02989   89 KIVKLLLKFGADINLKTFNGVSPIVCFIYNSNInncDMLRFLLSKGINVNDVKNSRGYNLLHMylESFSVKKDVIKILLS 168

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1958676820 179 QGADR-ECQDDFGITPLFV----AAQYGKLESLSILISSGANVN 217
Cdd:PHA02989  169 FGVNLfEKTSLYGLTPMNIylrnDIDVISIKVIKYLIKKGVNIE 212
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 128-150 3.05e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 3.05e-03
                           10        20
                   ....*....|....*....|...
gi 1958676820  128 FLAVESGQIDVLKLLLQHGANVN 150
Cdd:smart00248   7 HLAAENGNLEVVKLLLDKGADIN 29
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 69-211 8.61e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 38.59  E-value: 8.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820  69 CLQMLIHTDSSEnyiktKTFEGFCALHLAVSQGHWKVTQILLEAGADPNTTTL------EETTPLF--------LAVESG 134
Cdd:cd22194   125 ILDRFINAEYTE-----EAYEGQTALNIAIERRQGDIVKLLIAKGADVNAHAKgvffnpKYKHEGFyfgetplaLAACTN 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820 135 QIDVLKLLLQHGANVNGSHSMCGWNSLH------QASFQGNAEAIKL---LLKQGADRECQ---DDFGITPLFVAAQYGK 202
Cdd:cd22194   200 QPEIVQLLMEKESTDITSQDSRGNTVLHalvtvaEDSKTQNDFVKRMydmILLKSENKNLEtirNNEGLTPLQLAAKMGK 279


                  ....*....
gi 1958676820 203 LESLSILIS 211
Cdd:cd22194   280 AEILKYILS 288
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 2-115 9.51e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 38.43  E-value: 9.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676820   2 VTTVSTLIK-KMDFTEAYSDTCSTVGLAAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSE 80
Cdd:PHA02875  115 LDIMKLLIArGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANI 194

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1958676820  81 NYIKTKTfeGFCALHLAVSQGHWKVTQILLEAGAD 115
Cdd:PHA02875  195 DYFGKNG--CVAALCYAIENNKIDIVRLFIKRGAD 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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