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Conserved domains on  [gi|1958757954|ref|XP_038954942|]
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leucine-rich repeat-containing protein 20 isoform X3 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-89 2.98e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 2.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757954   4 FSQLRELRLEGNYLYRLPNEVSSLQHLRAIDLSRNQFQDFPEQLTTLPALETINLEENEIvADVPVEkLAAMPALRTINL 83
Cdd:COG4886   158 LTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQL-TDLPEP-LANLTNLETLDL 235


                  ....*.
gi 1958757954  84 RLNPLS 89
Cdd:COG4886   236 SNNQLT 241
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-89 2.98e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 2.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757954   4 FSQLRELRLEGNYLYRLPNEVSSLQHLRAIDLSRNQFQDFPEQLTTLPALETINLEENEIvADVPVEkLAAMPALRTINL 83
Cdd:COG4886   158 LTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQL-TDLPEP-LANLTNLETLDL 235


                  ....*.
gi 1958757954  84 RLNPLS 89
Cdd:COG4886   236 SNNQLT 241
PLN03150 PLN03150
hypothetical protein; Provisional
 20-92 4.42e-10

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 55.21  E-value: 4.42e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958757954  20 LPNEVSSLQHLRAIDLSRNQFQ-DFPEQLTTLPALETINLEENEIVADVPvEKLAAMPALRTINLRLNPLSAEV 92
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIP-ESLGQLTSLRILNLNGNSLSGRV 506
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 5-93 1.56e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 1.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757954   5 SQLRELRLEGNylyRLPNEVS-------------SLQHLraiDLSRNQFQDfPEQLTTLPALETINLEENEI--VADVpV 69
Cdd:cd21340    90 TNLEELHIENQ---RLPPGEKltfdprslaalsnSLRVL---NISGNNIDS-LEPLAPLRNLEQLDASNNQIsdLEEL-L 161

                          90       100
                  ....*....|....*....|....
gi 1958757954  70 EKLAAMPALRTINLRLNPLSAEVR 93
Cdd:cd21340   162 DLLSSWPSLRELDLTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
5-63 1.78e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 1.78e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958757954   5 SQLRELRLEGNYLYRLPNEV-SSLQHLRAIDLSRNQFQDF-PEQLTTLPALETINLEENEI 63
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-89 2.98e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 2.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757954   4 FSQLRELRLEGNYLYRLPNEVSSLQHLRAIDLSRNQFQDFPEQLTTLPALETINLEENEIvADVPVEkLAAMPALRTINL 83
Cdd:COG4886   158 LTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQL-TDLPEP-LANLTNLETLDL 235


                  ....*.
gi 1958757954  84 RLNPLS 89
Cdd:COG4886   236 SNNQLT 241
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-89 3.88e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 3.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757954   1 MTTFSQLRELRLEGNYLYRLPNEVSSLQHLRAIDLSRNQFQDFPEQLTTLPALETINLEENEIvADVPVEkLAAMPALRT 80
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQL-TDLPEE-LGNLTNLKE 186


                  ....*....
gi 1958757954  81 INLRLNPLS 89
Cdd:COG4886   187 LDLSNNQIT 195
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
5-89 5.23e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 5.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757954   5 SQLRELRLEGNYLYRLPNEVSSLQHLRAIDLSRNQFQDFPEqLTTLPALETINLEENEIvADVPveKLAAMPALRTINLR 84
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQL-TDLP--PLANLTNLKTLDLS 280


                  ....*
gi 1958757954  85 LNPLS 89
Cdd:COG4886   281 NNQLT 285
PLN03150 PLN03150
hypothetical protein; Provisional
 20-92 4.42e-10

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 55.21  E-value: 4.42e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958757954  20 LPNEVSSLQHLRAIDLSRNQFQ-DFPEQLTTLPALETINLEENEIVADVPvEKLAAMPALRTINLRLNPLSAEV 92
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIP-ESLGQLTSLRILNLNGNSLSGRV 506
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-89 4.82e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.55  E-value: 4.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757954   4 FSQLRELRLEGNylyrlpNEVSSLQHLRAIDLSRNQFQDFPEQLTTLPALETINLEENEIvADVPvEKLAAMPALRTINL 83
Cdd:COG4886    95 LTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQL-TDLP-EPLGNLTNLKSLDL 166


                  ....*.
gi 1958757954  84 RLNPLS 89
Cdd:COG4886   167 SNNQLT 172
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 5-93 1.56e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 1.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757954   5 SQLRELRLEGNylyRLPNEVS-------------SLQHLraiDLSRNQFQDfPEQLTTLPALETINLEENEI--VADVpV 69
Cdd:cd21340    90 TNLEELHIENQ---RLPPGEKltfdprslaalsnSLRVL---NISGNNIDS-LEPLAPLRNLEQLDASNNQIsdLEEL-L 161

                          90       100
                  ....*....|....*....|....
gi 1958757954  70 EKLAAMPALRTINLRLNPLSAEVR 93
Cdd:cd21340   162 DLLSSWPSLRELDLTGNPVCKKPK 185
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 3-88 8.26e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.99  E-value: 8.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757954   3 TFSQLRELRLEGNYLY-RLPNEVSSLQHLRAIDLSRNQFQ-DFPEQLTTLPALETINLEENEIVADVPvEKLAAMPALRT 80
Cdd:PLN00113  497 SLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSGEIP-KNLGNVESLVQ 575


                  ....*...
gi 1958757954  81 INLRLNPL 88
Cdd:PLN00113  576 VNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 5-92 1.17e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757954   5 SQLRELRLEGNYLY-RLPNEVSSLQHLRAIDLSRNQFQ-DFPEQLTTLPALETINLEENEIVADVPVEkLAAMPALRTIN 82
Cdd:PLN00113  140 PNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVGQIPRE-LGQMKSLKWIY 218

                          90
                  ....*....|
gi 1958757954  83 LRLNPLSAEV 92
Cdd:PLN00113  219 LGYNNLSGEI 228
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 6-92 2.94e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 2.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757954   6 QLRELRLEGN-YLYRLPNEVSSlQHLRAIDLSRNQFQD-FPEQLTTLPALETINLEENEIVADVPvEKLAAMPALRTINL 83
Cdd:PLN00113  453 SLQMLSLARNkFFGGLPDSFGS-KRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSGEIP-DELSSCKKLVSLDL 530


                  ....*....
gi 1958757954  84 RLNPLSAEV 92
Cdd:PLN00113  531 SHNQLSGQI 539
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-63 4.41e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 4.41e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958757954   1 MTTFSQLRELRLEGNYLYRLPnEVSSLQHLRAIDLSRNQFQDFPEqLTTLPALETINLEENEI 63
Cdd:COG4886   224 LANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
5-63 1.78e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 1.78e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958757954   5 SQLRELRLEGNYLYRLPNEV-SSLQHLRAIDLSRNQFQDF-PEQLTTLPALETINLEENEI 63
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 12-92 5.68e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 5.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757954  12 LEGNYLYR------LPNEVSSLQHLRAIDLSRNQFQ-DFPEQLTTLPALETINLEENEIVADVPVeKLAAMPALRTINLR 84
Cdd:PLN00113  262 LQYLFLYQnklsgpIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGKIPV-ALTSLPRLQVLQLW 340


                  ....*...
gi 1958757954  85 LNPLSAEV 92
Cdd:PLN00113  341 SNKFSGEI 348
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
5-113 1.29e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 39.76  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757954   5 SQLRELRLEGNYLYRLPNEVSSLQHLraiDLSRNQFQDFPEQLTTLPALETINLEENeivadvPVEKlAAMPALRTInlr 84
Cdd:PRK15387  402 SELKELMVSGNRLTSLPMLPSGLLSL---SVYRNQLTRLPESLIHLSSETTVNLEGN------PLSE-RTLQALREI--- 468

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958757954  85 lnplsAEVRVIAPPLIKFDM--LMTPEDTRA 113
Cdd:PRK15387  469 -----TSAPGYSGPIIRFDMagASAPRETRA 494
LRR_8 pfam13855
Leucine rich repeat;
28-88 1.58e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.58e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958757954  28 QHLRAIDLSRNQFQDF-PEQLTTLPALETINLEENEIVADVPVEkLAAMPALRTINLRLNPL 88
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-92 1.71e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757954   1 MTTFSQLRELRLEGNYLY-RLPNEVSSLQHLRAIDLSRNQFQ-DFPEQLTTLPALETINLEENEIVADVPVEkLAAMPAL 78
Cdd:PLN00113  160 IGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSGEIPYE-IGGLTSL 238

                          90
                  ....*....|....
gi 1958757954  79 RTINLRLNPLSAEV 92
Cdd:PLN00113  239 NHLDLVYNNLTGPI 252
PLN03150 PLN03150
hypothetical protein; Provisional
 3-87 1.60e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 36.72  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757954   3 TFSQLRELR---LEGNYLY-RLPNEVSSLQHLRAIDLSRNQFQ-DFPEQLTTLPALETINLEENEIVADVPVeKLAAMPA 77
Cdd:PLN03150  437 DISKLRHLQsinLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGRVPA-ALGGRLL 515

                          90
                  ....*....|.
gi 1958757954  78 LRTI-NLRLNP 87
Cdd:PLN03150  516 HRASfNFTDNA 526
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 7-91 1.76e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 36.18  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757954   7 LRELRLEGNYLY-----RLPNEVSSLQHLRAIDLSRNQFQDF-----PEQLTTLPALETINLEENEI----VADVpVEKL 72
Cdd:cd00116   139 LEKLVLGRNRLEgasceALAKALRANRDLKELNLANNGIGDAgiralAEGLKANCNLEVLDLNNNGLtdegASAL-AETL 217

                          90
                  ....*....|....*....
gi 1958757954  73 AAMPALRTINLRLNPLSAE 91
Cdd:cd00116   218 ASLKSLEVLNLGDNNLTDA 236
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 6-99 4.74e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 35.15  E-value: 4.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757954   6 QLRELRLEGNY-----LYRLPNEVSSLQHLRAIDLSRNQFQD-----FPEQLTTLPALETINLEENEIVADVPV---EKL 72
Cdd:COG5238   209 TVTTLWLKRNPigdegAEILAEALKGNKSLTTLDLSNNQIGDegviaLAEALKNNTTVETLYLSGNQIGAEGAIalaKAL 288

                          90       100
                  ....*....|....*....|....*...
gi 1958757954  73 AAMPALRTINLRLNPLSAE-VRVIAPPL 99
Cdd:COG5238   289 QGNTTLTSLDLSVNRIGDEgAIALAEGL 316
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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