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Conserved domains on  [gi|1958751278|ref|XP_038958487|]
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ankyrin repeat domain-containing protein 55 isoform X3 [Rattus norvegicus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11430360)

ankyrin repeat (ANK) domain-containing protein mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

CATH:  1.25.40.20
Gene Ontology:  GO:0005515
PubMed:  33435370|15152081|17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-249 2.42e-40

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 148.56  E-value: 2.42e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278   9 DLTMVYQAASNGDVNSLTAVIREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGW 88
Cdd:COG0666    53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  89 LEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGA 168
Cdd:COG0666   133 LEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA--DVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 169 DPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgpSIINYDDESGKTCVHIAAASGFGDIIHDLAKVPECNLQALDVDDR 248
Cdd:COG0666   211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAG---ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287


                  .
gi 1958751278 249 T 249
Cdd:COG0666   288 L 288
Ank_2 pfam12796
Ankyrin repeats (3 copies);
218-299 9.05e-15

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 9.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 218 HIAAASGFGDIIHDLAKvPECNLQALDVDDRTPLHWAAAAGKAECVQSLLDlGMDSNLRDiNESTPLAYALYCGHTACVR 297
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 1958751278 298 LL 299
Cdd:pfam12796  79 LL 80
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-249 2.42e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 148.56  E-value: 2.42e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278   9 DLTMVYQAASNGDVNSLTAVIREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGW 88
Cdd:COG0666    53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  89 LEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGA 168
Cdd:COG0666   133 LEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA--DVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 169 DPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgpSIINYDDESGKTCVHIAAASGFGDIIHDLAKVPECNLQALDVDDR 248
Cdd:COG0666   211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAG---ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287


                  .
gi 1958751278 249 T 249
Cdd:COG0666   288 L 288
PHA03095 PHA03095
ankyrin-like protein; Provisional
 3-297 1.84e-23

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 103.95  E-value: 1.84e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278   3 DSSEEVDLTMVYQAASNGDVNSLTAVIREDPSIlECCDSEGCTPL---MHAVSGRQVDTVKLLLKMGANINTQDAYGRTS 79
Cdd:PHA03095    8 DIIMEAALYDYLLNASNVTVEEVRRLLAAGADV-NFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTP 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  80 LCLATYLGWLEGCVSLL-RNGAKHNIPDKNGRLPLHA-----ATAEPDVRLLIVLLqqsslSEINHQDTEGMTPLH-WAA 152
Cdd:PHA03095   87 LHLYLYNATTLDVIKLLiKAGADVNAKDKVGRTPLHVylsgfNINPKVIRLLLRKG-----ADVNALDLYGMTPLAvLLK 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 153 FHNRPQHT-QMLLKKGADPTLVDKDFKTALHWAVQS---GNRILCSIIlSHRQGPSIINyddESGKTCVHIAAASGFGDI 228
Cdd:PHA03095  162 SRNANVELlRLLIDAGADVYAVDDRFRSLLHHHLQSfkpRARIVRELI-RAGCDPAATD---MLGNTPLHSMATGSSCKR 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958751278 229 IHdLAKVPECNLQ--ALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVR 297
Cdd:PHA03095  238 SL-VLPLLIAGISinARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
Ank_2 pfam12796
Ankyrin repeats (3 copies);
47-174 3.73e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.92  E-value: 3.73e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  47 LMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEgCVSLLrngAKHNIPDKngrlplhaataepdvrlli 126
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLE-IVKLL---LEHADVNL------------------- 57

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958751278 127 vllqqsslseinhqDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVD 174
Cdd:pfam12796  58 --------------KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
218-299 9.05e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 9.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 218 HIAAASGFGDIIHDLAKvPECNLQALDVDDRTPLHWAAAAGKAECVQSLLDlGMDSNLRDiNESTPLAYALYCGHTACVR 297
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 1958751278 298 LL 299
Cdd:pfam12796  79 LL 80
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 42-70 9.46e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.57  E-value: 9.46e-06
                           10        20
                   ....*....|....*....|....*....
gi 1958751278   42 EGCTPLMHAVSGRQVDTVKLLLKMGANIN 70
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 209-299 1.56e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.94  E-value: 1.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 209 DDESGKTCVHIAAASGFGDIIHDLAKVpecNLQAlDVDD---RTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLA 285
Cdd:PLN03192  521 DDPNMASNLLTVASTGNAALLEELLKA---KLDP-DIGDskgRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALW 596

                          90
                  ....*....|....
gi 1958751278 286 YALYCGHTACVRLL 299
Cdd:PLN03192  597 NAISAKHHKIFRIL 610
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 246-275 4.47e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 4.47e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958751278  246 DDRTPLHWAAAAGKAECVQSLLDLGMDSNL 275
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 11-166 1.69e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.15  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  11 TMVYQAASNGDVNSLTAVIREDPS-ILECCDSE---GCTPLMHAVSGRQVDTVKLLLKMGANINTQDA------------ 74
Cdd:cd22192    53 TALHVAALYDNLEAAVVLMEAAPElVNEPMTSDlyqGETALHIAVVNQNLNLVRELIARGADVVSPRAtgtffrpgpknl 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  75 --YGRTSLCLATYLGwLEGCVSLL-RNGAKHNIPDKNGRLPLHAATAEPDVRL------LIV----LLQQSSLSEI-NHQ 140
Cdd:cd22192   133 iyYGEHPLSFAACVG-NEEIVRLLiEHGADIRAQDSLGNTVLHILVLQPNKTFacqmydLILsydkEDDLQPLDLVpNNQ 211

                         170       180
                  ....*....|....*....|....*.
gi 1958751278 141 dteGMTPLHWAAFHNRPQHTQMLLKK 166
Cdd:cd22192   212 ---GLTPFKLAAKEGNIVMFQHLVQK 234
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-249 2.42e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 148.56  E-value: 2.42e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278   9 DLTMVYQAASNGDVNSLTAVIREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGW 88
Cdd:COG0666    53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  89 LEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGA 168
Cdd:COG0666   133 LEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA--DVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 169 DPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgpSIINYDDESGKTCVHIAAASGFGDIIHDLAKVPECNLQALDVDDR 248
Cdd:COG0666   211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAG---ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287


                  .
gi 1958751278 249 T 249
Cdd:COG0666   288 L 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
40-284 1.49e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 140.86  E-value: 1.49e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  40 DSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE 119
Cdd:COG0666    51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 120 PDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSH 199
Cdd:COG0666   131 GNLEIVKLLLEAG--ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 200 RqgpSIINYDDESGKTCVHIAAASGFGDIIHDLAKVPEcNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDIN 279
Cdd:COG0666   209 G---ADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA-DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284


                  ....*
gi 1958751278 280 ESTPL 284
Cdd:COG0666   285 LLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
45-309 3.15e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 131.61  E-value: 3.15e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  45 TPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRL 124
Cdd:COG0666    23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEI 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 125 LIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgps 204
Cdd:COG0666   103 VKLLLEAGA--DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAG---- 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 205 iinyddesgktcvhiaaasgfgdiihdlakvpeCNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPL 284
Cdd:COG0666   177 ---------------------------------ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223

                         250       260
                  ....*....|....*....|....*
gi 1958751278 285 AYALYCGHTACVRLLSREGRAEPAR 309
Cdd:COG0666   224 DLAAENGNLEIVKLLLEAGADLNAK 248
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
59-299 2.50e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 109.27  E-value: 2.50e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  59 VKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAepDVRLLIVLLQQSSLSEIN 138
Cdd:COG0666     4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAAL--AGDLLVALLLLAAGADIN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 139 HQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgpsiinyddesgktcvh 218
Cdd:COG0666    82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAG------------------ 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 219 iaaasgfgdiihdlAKVpecNLQalDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRL 298
Cdd:COG0666   144 --------------ADV---NAQ--DNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKL 204


                  .
gi 1958751278 299 L 299
Cdd:COG0666   205 L 205
PHA03095 PHA03095
ankyrin-like protein; Provisional
 3-297 1.84e-23

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 103.95  E-value: 1.84e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278   3 DSSEEVDLTMVYQAASNGDVNSLTAVIREDPSIlECCDSEGCTPL---MHAVSGRQVDTVKLLLKMGANINTQDAYGRTS 79
Cdd:PHA03095    8 DIIMEAALYDYLLNASNVTVEEVRRLLAAGADV-NFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTP 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  80 LCLATYLGWLEGCVSLL-RNGAKHNIPDKNGRLPLHA-----ATAEPDVRLLIVLLqqsslSEINHQDTEGMTPLH-WAA 152
Cdd:PHA03095   87 LHLYLYNATTLDVIKLLiKAGADVNAKDKVGRTPLHVylsgfNINPKVIRLLLRKG-----ADVNALDLYGMTPLAvLLK 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 153 FHNRPQHT-QMLLKKGADPTLVDKDFKTALHWAVQS---GNRILCSIIlSHRQGPSIINyddESGKTCVHIAAASGFGDI 228
Cdd:PHA03095  162 SRNANVELlRLLIDAGADVYAVDDRFRSLLHHHLQSfkpRARIVRELI-RAGCDPAATD---MLGNTPLHSMATGSSCKR 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958751278 229 IHdLAKVPECNLQ--ALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVR 297
Cdd:PHA03095  238 SL-VLPLLIAGISinARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
PHA03095 PHA03095
ankyrin-like protein; Provisional
 56-299 2.15e-22

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 100.48  E-value: 2.15e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  56 VDTVKLLLKMGANINTQDAYGRTSLC--LATYLGWLEGCVS-LLRNGAKHNIPDKNGRLPLHA----ATAEPDVRLLIvl 128
Cdd:PHA03095   27 VEEVRRLLAAGADVNFRGEYGKTPLHlyLHYSSEKVKDIVRlLLEAGADVNAPERCGFTPLHLylynATTLDVIKLLI-- 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 129 lqqSSLSEINHQDTEGMTPLH--WAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN------RILCsiilshR 200
Cdd:PHA03095  105 ---KAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanvellRLLI------D 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 201 QGPSIINYDDEsGKTCVHIAAAS--GFGDIIHDLAkVPECNLQALDVDDRTPLHWAAAAG--KAECVQSLLDLGMDSNLR 276
Cdd:PHA03095  176 AGADVYAVDDR-FRSLLHHHLQSfkPRARIVRELI-RAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISINAR 253

                         250       260
                  ....*....|....*....|....
gi 1958751278 277 DINESTPLAYA-LYCGHTACVRLL 299
Cdd:PHA03095  254 NRYGQTPLHYAaVFNNPRACRRLI 277
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 50-205 2.05e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 81.64  E-value: 2.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  50 AVSGRQVDTVKLLLKMGANINTQDAYGRTSL--CLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIV 127
Cdd:PHA03100   80 YNLTDVKEIVKLLLEYGANVNAPDNNGITPLlyAISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKIL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 128 --LLQQ--------------SSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRI 191
Cdd:PHA03100  160 klLIDKgvdinaknrvnyllSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKE 239

                         170
                  ....*....|....
gi 1958751278 192 LCSIILSHrqGPSI 205
Cdd:PHA03100  240 IFKLLLNN--GPSI 251
Ank_2 pfam12796
Ankyrin repeats (3 copies);
47-174 3.73e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.92  E-value: 3.73e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  47 LMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEgCVSLLrngAKHNIPDKngrlplhaataepdvrlli 126
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLE-IVKLL---LEHADVNL------------------- 57

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958751278 127 vllqqsslseinhqDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVD 174
Cdd:pfam12796  58 --------------KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
218-299 9.05e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 9.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 218 HIAAASGFGDIIHDLAKvPECNLQALDVDDRTPLHWAAAAGKAECVQSLLDlGMDSNLRDiNESTPLAYALYCGHTACVR 297
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 1958751278 298 LL 299
Cdd:pfam12796  79 LL 80
Ank_2 pfam12796
Ankyrin repeats (3 copies);
181-277 9.98e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 9.98e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 181 LHWAVQSGNRILCSIILSHRQGPsiiNYDDESGKTCVHIAAASGFGDIIHDLAKVPECNLQaldVDDRTPLHWAAAAGKA 260
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADA---NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHL 74

                          90
                  ....*....|....*..
gi 1958751278 261 ECVQSLLDLGMDSNLRD 277
Cdd:pfam12796  75 EIVKLLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 44-303 1.11e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.16  E-value: 1.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  44 CTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLclatylgwlegcvSLLRNgAKHNIPDkngrlplhaataepDVR 123
Cdd:PHA03100   36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPL-------------HYLSN-IKYNLTD--------------VKE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 124 LLIVLLQQSSLseINHQDTEGMTPLHWAAfHNRPQHTQM---LLKKGADPTLVDKDFKTALHWAVQSGNRIL--CSIILS 198
Cdd:PHA03100   88 IVKLLLEYGAN--VNAPDNNGITPLLYAI-SKKSNSYSIveyLLDNGANVNIKNSDGENLLHLYLESNKIDLkiLKLLID 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 199 HrqgpsIINYDdesGKTCVHIAAASGfgdiihdlakvpeCNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDI 278
Cdd:PHA03100  165 K-----GVDIN---AKNRVNYLLSYG-------------VPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNK 223

                         250       260
                  ....*....|....*....|....*
gi 1958751278 279 NESTPLAYALYCGHTACVRLLSREG 303
Cdd:PHA03100  224 YGDTPLHIAILNNNKEIFKLLLNNG 248
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 8-287 1.25e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 73.94  E-value: 1.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278   8 VDLTMVYQAasngDVNSLTAvirEDPSILECcdsegctplmhAVSGRQVDTVKLLLKMGANINTQDaygrTSLCLATYLG 87
Cdd:PHA02876  194 VNLLLSYGA----DVNIIAL---DDLSVLEC-----------AVDSKNIDTIKAIIDNRSNINKND----LSLLKAIRNE 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  88 WLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDV-RLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHN-RPQHTQMLLK 165
Cdd:PHA02876  252 DLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERGA--DVNAKNIKGETPLYLMAKNGyDTENIRTLIM 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 166 KGADPTLVDKDFKTALHWAvQSGNRILCSIILSHRQGPSIiNYDDESGKTCVHIAAASGFGDIIHDLAKVpECNLQALDV 245
Cdd:PHA02876  330 LGADVNAADRLYITPLHQA-STLDRNKDIVITLLELGANV-NARDYCDKTPIHYAAVRNNVVIINTLLDY-GADIEALSQ 406

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1958751278 246 DDRTPLHWA-AAAGKAECVQSLLDLGMDSNLRDINESTPLAYA 287
Cdd:PHA02876  407 KIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYA 449
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 34-220 2.74e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 72.30  E-value: 2.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  34 SILECC------DSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDK 107
Cdd:PHA02874  109 TILDCGidvnikDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDN 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 108 NGRLPLHAATAEPDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFHNRPqhTQMLLKKGADPTLVDKDFKTALHWAVQS 187
Cdd:PHA02874  189 NGESPLHNAAEYGDYACIKLLIDHG--NHIMNKCKNGFTPLHNAIIHNRS--AIELLINNASINDQDIDGSTPLHHAINP 264

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958751278 188 GNRI-LCSIILSHRQGPSIinyDDESGKTCVHIA 220
Cdd:PHA02874  265 PCDIdIIDILLYHKADISI---KDNKGENPIDTA 295
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 19-288 2.99e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 71.92  E-value: 2.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  19 NGDVNSLTAVIREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLG-------WLEG 91
Cdd:PHA02874   11 SGDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGahdiiklLIDN 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  92 CV----------------SLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFHN 155
Cdd:PHA02874   91 GVdtsilpipciekdmikTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYG--ADVNIEDDNGCYPIHIAIKHN 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 156 RPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHrqGPSIINyDDESGKTCVHIAaasgfgdIIHDLAKV 235
Cdd:PHA02874  169 FFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDH--GNHIMN-KCKNGFTPLHNA-------IIHNRSAI 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958751278 236 P----ECNLQALDVDDRTPLHWA-AAAGKAECVQSLLDLGMDSNLRDINESTPLAYAL 288
Cdd:PHA02874  239 EllinNASINDQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKDNKGENPIDTAF 296
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 45-303 4.74e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 72.02  E-value: 4.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  45 TPLMHAVSGRQVDT-VKLLLKMGANINTQDAYGRTSLCLATYLGW-LEGCVSLLRNGAKHNIPDKNGRLPLH-AATAEPD 121
Cdd:PHA02876  275 TPLHHASQAPSLSRlVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHqASTLDRN 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 122 VRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILcsiilshrq 201
Cdd:PHA02876  355 KDIVITLLELGA--NVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYM--------- 423

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 202 gpsiinyddeSGKTCVHIAAasgfgdiihdlakvpecNLQALDVDDRTPLHWAAAAG-KAECVQSLLDLGMDSNLRDINE 280
Cdd:PHA02876  424 ----------SVKTLIDRGA-----------------NVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQN 476

                         250       260
                  ....*....|....*....|...
gi 1958751278 281 STPLAYALycGHTACVRLLSREG 303
Cdd:PHA02876  477 QYPLLIAL--EYHGIVNILLHYG 497
PHA03095 PHA03095
ankyrin-like protein; Provisional
 39-205 7.95e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 70.82  E-value: 7.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  39 CDSEGCTPLMHAVSGRQVD--TVKLLLKMGANINTQDAYGRTSL-CLATYLGWLEGCVS-LLRNGAKHNIPDKNGRLPLH 114
Cdd:PHA03095  148 LDLYGMTPLAVLLKSRNANveLLRLLIDAGADVYAVDDRFRSLLhHHLQSFKPRARIVReLIRAGCDPAATDMLGNTPLH 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 115 -AATAEPDVRLLIVLLQQSSLSeINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILC 193
Cdd:PHA03095  228 sMATGSSCKRSLVLPLLIAGIS-INARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAV 306

                         170
                  ....*....|..
gi 1958751278 194 SIILSHRqgPSI 205
Cdd:PHA03095  307 RAALAKN--PSA 316
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 47-275 5.16e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 68.09  E-value: 5.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  47 LMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLI 126
Cdd:PHA02875    6 LCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 127 VLLQQSS-LSEINHQDteGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgpSI 205
Cdd:PHA02875   86 ELLDLGKfADDVFYKD--GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHK---AC 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958751278 206 INYDDESGKTCVHIAAASGFGDI---IHDLAKVPECNLQALDVddrTPLHWAAAAGKAECVQSLLDLGMDSNL 275
Cdd:PHA02875  161 LDIEDCCGCTPLIIAMAKGDIAIckmLLDSGANIDYFGKNGCV---AALCYAIENNKIDIVRLFIKRGADCNI 230
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 43-207 2.58e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 66.06  E-value: 2.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  43 GCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE-PD 121
Cdd:PHA02878  168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKD 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 122 VRLLIVLLQQSslSEINHQDT-EGMTPLHwAAFHNrPQHTQMLLKKGADPTLVDKDFKTALHWAVQS------GNRILCS 194
Cdd:PHA02878  248 YDILKLLLEHG--VDVNAKSYiLGLTALH-SSIKS-ERKLKLLLEYGADINSLNSYKLTPLSSAVKQylciniGRILISN 323

                         170
                  ....*....|...
gi 1958751278 195 IILSHRQGPSIIN 207
Cdd:PHA02878  324 ICLLKRIKPDIKN 336
Ank_2 pfam12796
Ankyrin repeats (3 copies);
251-299 1.83e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.82  E-value: 1.83e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958751278 251 LHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 299
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL 49
Ank_2 pfam12796
Ankyrin repeats (3 copies);
113-199 4.66e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.66  E-value: 4.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 113 LHAATAEPDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKgADPTLVDKDfKTALHWAVQSGNRIL 192
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA--DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEI 76


                  ....*..
gi 1958751278 193 CSIILSH 199
Cdd:pfam12796  77 VKLLLEK 83
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 13-173 6.29e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 61.55  E-value: 6.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  13 VYQAASNGDVNSLTAVIREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGC 92
Cdd:PHA02875   72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  93 VSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLqqSSLSEINHQDTEG-MTPLHWAAFHNRPQHTQMLLKKGADPT 171
Cdd:PHA02875  152 ELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLL--DSGANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGADCN 229


                  ..
gi 1958751278 172 LV 173
Cdd:PHA02875  230 IM 231
Ank_4 pfam13637
Ankyrin repeats (many copies);
248-299 7.67e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.59  E-value: 7.67e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958751278 248 RTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 299
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 44-300 1.46e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 60.66  E-value: 1.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  44 CTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSL---CLA--------------------TYLGWLEGC-------- 92
Cdd:PHA02878   38 FIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLhiiCKEpnklgmkemirsinkcsvfyTLVAIKDAFnnrnveif 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  93 VSLLRNGAKHN--IPDKNgrlpLHAATAEPDVRLLIVLLQQSSLSEINHQDTE-GMTPLHWAAFHNRPQHTQMLLKKGAD 169
Cdd:PHA02878  118 KIILTNRYKNIqtIDLVY----IDKKSKDDIIEAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGAN 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 170 PTLVDKDFKTALHWAVQSGNRILCSIILshRQGPSiINYDDESGKTCVHIAAASGFG-DIIHDLAKVPEC-NLQAlDVDD 247
Cdd:PHA02878  194 VNIPDKTNNSPLHHAVKHYNKPIVHILL--ENGAS-TDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDvNAKS-YILG 269

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958751278 248 RTPLHwaAAAGKAECVQSLLDLGMDSNLRDINESTPLAYAL--YCGHTACVRLLS 300
Cdd:PHA02878  270 LTALH--SSIKSERKLKLLLEYGADINSLNSYKLTPLSSAVkqYLCINIGRILIS 322
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 5-284 1.01e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 58.15  E-value: 1.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278   5 SEEVDLTMVYQAASNGDVNSLTAVIREDPSILECCDSEgCTPLMHAVS-GRQVDTVKLLLKMGANINTQDAYgrTSLCLA 83
Cdd:PHA02876   37 NESIPFTAIHQALQLRQIDIVEEIIQQNPELIYITDHK-CHSTLHTICiIPNVMDIVISLTLDCDIILDIKY--ASIILN 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  84 TY-LGwlEGCVSLLRNGAKHN------IPDKNGRLPLHAATAEPDvRLLIVLLQQSSLSEINHQDTEGMTPLHWAAFHNR 156
Cdd:PHA02876  114 KHkLD--EACIHILKEAISGNdihydkINESIEYMKLIKERIQQD-ELLIAEMLLEGGADVNAKDIYCITPIHYAAERGN 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 157 PQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgpSIINYDDESGKTCVH--------IAAASGFgdi 228
Cdd:PHA02876  191 AKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNR---SNINKNDLSLLKAIRnedletslLLYDAGF--- 264

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958751278 229 ihdlakvpecNLQALDVDDRTPLHWAAAAGK-AECVQSLLDLGMDSNLRDINESTPL 284
Cdd:PHA02876  265 ----------SVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPL 311
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 77-303 2.10e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 56.54  E-value: 2.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  77 RTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSSLSEINHQDTEgmTPLHWAAFHNR 156
Cdd:PHA02875    3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIE--SELHDAVEEGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 157 PQHTQMLLKKGadpTLVD----KDFKTALHWAVQSGNRILCSIILSHRQGPSIINYDDesgKTCVHIAAASGFGDIIHDL 232
Cdd:PHA02875   81 VKAVEELLDLG---KFADdvfyKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDK---FSPLHLAVMMGDIKGIELL 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958751278 233 AKVPECnlqaLDVDD---RTPLHWAAAAGKAECVQSLLDLGMDSNLRDIN-ESTPLAYALYCGHTACVRLLSREG 303
Cdd:PHA02875  155 IDHKAC----LDIEDccgCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRG 225
Ank_5 pfam13857
Ankyrin repeats (many copies);
238-287 5.54e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 49.65  E-value: 5.54e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958751278 238 CNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYA 287
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
144-189 6.60e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 6.60e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958751278 144 GMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN 189
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGN 46
Ank_2 pfam12796
Ankyrin repeats (3 copies);
3-73 9.31e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.11  E-value: 9.31e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958751278   3 DSSEEVDLTMVYQAASNGDVNSLTAVIREDPSileCCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQD 73
Cdd:pfam12796  24 NLQDKNGRTALHLAAKNGHLEIVKLLLEHADV---NLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 122-201 1.20e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.90  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 122 VRLLIvllqqSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQ 201
Cdd:PTZ00322   98 ARILL-----TGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQ 172
Ank_5 pfam13857
Ankyrin repeats (many copies);
128-184 1.35e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.42  E-value: 1.35e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958751278 128 LLQQSSLSeINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWA 184
Cdd:pfam13857   1 LLEHGPID-LNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
109-164 5.29e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 5.29e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958751278 109 GRLPLHAATAEPDVRLLIVLLQqsSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLL 164
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLE--KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02946 PHA02946
ankyin-like protein; Provisional
 138-284 5.79e-06

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 48.90  E-value: 5.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 138 NHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGPSIINYDDESGktCV 217
Cdd:PHA02946   66 NETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIERINLLVQYGAKINNSVDEEG--CG 143

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958751278 218 HIAAASGFGDIIhdLAKVPECNLQALDVD----DRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPL 284
Cdd:PHA02946  144 PLLACTDPSERV--FKKIMSIGFEARIVDkfgkNHIHRHLMSDNPKASTISWMMKLGISPSKPDHDGNTPL 212
Ank_5 pfam13857
Ankyrin repeats (many copies);
29-83 8.16e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.49  E-value: 8.16e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958751278  29 IREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLA 83
Cdd:pfam13857   2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 42-70 9.46e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.57  E-value: 9.46e-06
                           10        20
                   ....*....|....*....|....*....
gi 1958751278   42 EGCTPLMHAVSGRQVDTVKLLLKMGANIN 70
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 209-299 1.56e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.94  E-value: 1.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 209 DDESGKTCVHIAAASGFGDIIHDLAKVpecNLQAlDVDD---RTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLA 285
Cdd:PLN03192  521 DDPNMASNLLTVASTGNAALLEELLKA---KLDP-DIGDskgRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALW 596

                          90
                  ....*....|....
gi 1958751278 286 YALYCGHTACVRLL 299
Cdd:PLN03192  597 NAISAKHHKIFRIL 610
PHA02798 PHA02798
ankyrin-like protein; Provisional
 56-196 4.45e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 46.37  E-value: 4.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  56 VDTVKLLLKMGANINTQDAYGRTSLC-----LATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAataepdvrllivLLQ 130
Cdd:PHA02798   51 TDIVKLFINLGANVNGLDNEYSTPLCtilsnIKDYKHMLDIVKILIENGADINKKNSDGETPLYC------------LLS 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958751278 131 QSSLseinhqdtegmtplhwaafhNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSII 196
Cdd:PHA02798  119 NGYI--------------------NNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHIDIEII 164
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 42-73 5.02e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 5.02e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1958751278  42 EGCTPLMHAV-SGRQVDTVKLLLKMGANINTQD 73
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 143-175 5.43e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 5.43e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1958751278 143 EGMTPLHWAAFH-NRPQHTQMLLKKGADPTLVDK 175
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 143-170 1.05e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.55  E-value: 1.05e-04
                          10        20
                  ....*....|....*....|....*...
gi 1958751278 143 EGMTPLHWAAFHNRPQHTQMLLKKGADP 170
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
Ank_4 pfam13637
Ankyrin repeats (many copies);
45-96 1.11e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 1.11e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958751278  45 TPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEgCVSLL 96
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVE-VLKLL 53
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1-176 1.21e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 45.24  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278   1 MGDSSEE-VDLTM---VYQAASNGDVNSLTAVIR--EDPSIlecCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDA 74
Cdd:PLN03192  513 LGDNGGEhDDPNMasnLLTVASTGNAALLEELLKakLDPDI---GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDA 589

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  75 YGRTSLCLATYLGWLEgCVSLLRNGAKHNIPDKNGRLpLHAATAEPDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFH 154
Cdd:PLN03192  590 NGNTALWNAISAKHHK-IFRILYHFASISDPHAAGDL-LCTAAKRNDLTAMKELLKQG--LNVDSEDHQGATALQVAMAE 665

                         170       180
                  ....*....|....*....|..
gi 1958751278 155 NRPQHTQMLLKKGADPTLVDKD 176
Cdd:PLN03192  666 DHVDMVRLLIMNGADVDKANTD 687
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 143-172 1.34e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.11  E-value: 1.34e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958751278  143 EGMTPLHWAAFHNRPQHTQMLLKKGADPTL 172
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 244-301 1.44e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.89  E-value: 1.44e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958751278 244 DVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLLSR 301
Cdd:PTZ00322  112 DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 4-138 1.80e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.50  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278   4 SSEEVDLTMVYQAASNGDVnsltavireDPSILECCDSEGCTplmHAVSGRQVDtVKLLLKMGANINTQDAYGRTSLCLA 83
Cdd:PTZ00322   56 ATENKDATPDHNLTTEEVI---------DPVVAHMLTVELCQ---LAASGDAVG-ARILLTGGADPNCRDYDGRTPLHIA 122

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958751278  84 TYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAAtAEPDVRLLIVLLQQSSLSEIN 138
Cdd:PTZ00322  123 CANGHVQVVRVLLEFGADPTLLDKDGKTPLELA-EENGFREVVQLLSRHSQCHFE 176
PHA02791 PHA02791
ankyrin-like protein; Provisional
 106-189 1.87e-04

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 43.88  E-value: 1.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 106 DKNGRLPLHAATAEPDVRLLIVLLQQSSLSEInhqdTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAV 185
Cdd:PHA02791   27 DVHGHSALYYAIADNNVRLVCTLLNAGALKNL----LENEFPLHQAATLEDTKIVKILLFSGMDDSQFDDKGNTALYYAV 102


                  ....
gi 1958751278 186 QSGN 189
Cdd:PHA02791  103 DSGN 106
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 246-277 2.46e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.42  E-value: 2.46e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1958751278 246 DDRTPLHWAAA-AGKAECVQSLLDLGMDSNLRD 277
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 161-242 2.79e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.73  E-value: 2.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 161 QMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGPSIInydDESGKTCVHIAAASGFGDIIHDLAKVPECNL 240
Cdd:PTZ00322   99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLL---DKDGKTPLELAEENGFREVVQLLSRHSQCHF 175


                  ..
gi 1958751278 241 QA 242
Cdd:PTZ00322  176 EL 177
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 42-71 3.58e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.01  E-value: 3.58e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958751278  42 EGCTPLMHAVSGRQVDTVKLLLKMGANINT 71
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 246-275 4.47e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 4.47e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958751278  246 DDRTPLHWAAAAGKAECVQSLLDLGMDSNL 275
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 11-166 1.69e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.15  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  11 TMVYQAASNGDVNSLTAVIREDPS-ILECCDSE---GCTPLMHAVSGRQVDTVKLLLKMGANINTQDA------------ 74
Cdd:cd22192    53 TALHVAALYDNLEAAVVLMEAAPElVNEPMTSDlyqGETALHIAVVNQNLNLVRELIARGADVVSPRAtgtffrpgpknl 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  75 --YGRTSLCLATYLGwLEGCVSLL-RNGAKHNIPDKNGRLPLHAATAEPDVRL------LIV----LLQQSSLSEI-NHQ 140
Cdd:cd22192   133 iyYGEHPLSFAACVG-NEEIVRLLiEHGADIRAQDSLGNTVLHILVLQPNKTFacqmydLILsydkEDDLQPLDLVpNNQ 211

                         170       180
                  ....*....|....*....|....*.
gi 1958751278 141 dteGMTPLHWAAFHNRPQHTQMLLKK 166
Cdd:cd22192   212 ---GLTPFKLAAKEGNIVMFQHLVQK 234
PHA02798 PHA02798
ankyrin-like protein; Provisional
 40-149 2.02e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.97  E-value: 2.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  40 DSEGCTPLMHAVSG-----RQVDTVKLLLKMGANINTQDAYGRTSLCLA---TYLGWLEGCVSLLRNGAKHNIPDKNGRL 111
Cdd:PHA02798   68 DNEYSTPLCTILSNikdykHMLDIVKILIENGADINKKNSDGETPLYCLlsnGYINNLEILLFMIENGADTTLLDKDGFT 147

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1958751278 112 PLHA---ATAEPDVRLLIVLLQQSslSEIN-HQDTEGMTPLH 149
Cdd:PHA02798  148 MLQVylqSNHHIDIEIIKLLLEKG--VDINtHNNKEKYDTLH 187
Ank_4 pfam13637
Ankyrin repeats (many copies);
179-232 2.11e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 2.11e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958751278 179 TALHWAVQSGNRILCSIILSHRQgpsIINYDDESGKTCVHIAAASGFGDIIHDL 232
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGA---DINAVDGNGETALHFAASNGNVEVLKLL 53
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 193-288 2.95e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.43  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 193 CSIILSHRQGPSIINyDDESGKTCVHIAAASGFGDIIH--------------------DLAKVPE------CNLQALDVD 246
Cdd:PHA02876   99 CDIILDIKYASIILN-KHKLDEACIHILKEAISGNDIHydkinesieymklikeriqqDELLIAEmlleggADVNAKDIY 177

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1958751278 247 DRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYAL 288
Cdd:PHA02876  178 CITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAV 219
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 231-299 3.46e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.27  E-value: 3.46e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958751278 231 DLAKVPECNLQALDVDDRTPLHWA-------AAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 299
Cdd:PTZ00322   59 NKDATPDHNLTTEEVIDPVVAHMLtvelcqlAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVL 134
PHA02946 PHA02946
ankyin-like protein; Provisional
 34-241 4.50e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 39.65  E-value: 4.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278  34 SILECCDSEGCTPLMHA---VSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGR 110
Cdd:PHA02946   27 NMLQAIEPSGNYHILHAycgIKGLDERFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHK 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 111 LPLHAATAEPD-VRLLIVLLQQSSLSEINHQDTEGMTPLhWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN 189
Cdd:PHA02946  107 TPLYYLSGTDDeVIERINLLVQYGAKINNSVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIHRHLMSDN 185

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958751278 190 RILCSIILSHRQGPSiINYDDESGKTCVHIAAASGFG--DIIHDLAKVPECNLQ 241
Cdd:PHA02946  186 PKASTISWMMKLGIS-PSKPDHDGNTPLHIVCSKTVKnvDIINLLLPSTDVNKQ 238
Ank_4 pfam13637
Ankyrin repeats (many copies);
76-129 4.84e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.33  E-value: 4.84e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958751278  76 GRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLL 129
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 246-274 6.76e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.54  E-value: 6.76e-03
                          10        20
                  ....*....|....*....|....*....
gi 1958751278 246 DDRTPLHWAAAAGKAECVQSLLDLGMDSN 274
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
Ank_4 pfam13637
Ankyrin repeats (many copies);
215-267 8.24e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.94  E-value: 8.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958751278 215 TCVHIAAASGFGDIIHDLAKVPeCNLQALDVDDRTPLHWAAAAGKAECVQSLL 267
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKG-ADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 111-189 8.29e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.23  E-value: 8.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751278 111 LPLHAATAEPDVRLLIVLLQQSSlSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKkgADPTLVDK----DF---KTALHW 183
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLKCPS-CDLFQRGALGETALHVAALYDNLEAAVVLME--AAPELVNEpmtsDLyqgETALHI 95


                  ....*.
gi 1958751278 184 AVQSGN 189
Cdd:cd22192    96 AVVNQN 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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