NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958752077|ref|XP_038958799|]
View 

leucine-rich repeat-containing protein 34 isoform X1 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 67-344 1.09e-34

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 133.38  E-value: 1.09e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077  67 SKALRNHPcIGGVDVRYNLIGDVGAYYAAKLLQKQPNITYLNLMFNDIGPEGGELIAKALQKNKTLKYLRMTGNKIENTG 146
Cdd:COG5238   174 AKALQNNS-VETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEG 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 147 GMLFAAMLQMNSSLEKLDLGDCDLGLQSVIAFSTVLTQNKAIKGINLNrpilygeqeestvhighmlkQNHVLVElhmck 226
Cdd:COG5238   253 VIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLS--------------------VNRIGDE----- 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 227 hgmknyGIQQLCNALHSNSTLRYLDVSCNKITRDGMVFLADVLKSNSTLEVLDLSFNRIENAGAKYLSETLTShNRSLKA 306
Cdd:COG5238   308 ------GAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEG-NTTLRE 380

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1958752077 307 LSVVSNKIEGEGLVALSQSMNTNLVLSNIYIWGNKFDE 344
Cdd:COG5238   381 LNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLIGAE 418
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 67-344 1.09e-34

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 133.38  E-value: 1.09e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077  67 SKALRNHPcIGGVDVRYNLIGDVGAYYAAKLLQKQPNITYLNLMFNDIGPEGGELIAKALQKNKTLKYLRMTGNKIENTG 146
Cdd:COG5238   174 AKALQNNS-VETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEG 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 147 GMLFAAMLQMNSSLEKLDLGDCDLGLQSVIAFSTVLTQNKAIKGINLNrpilygeqeestvhighmlkQNHVLVElhmck 226
Cdd:COG5238   253 VIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLS--------------------VNRIGDE----- 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 227 hgmknyGIQQLCNALHSNSTLRYLDVSCNKITRDGMVFLADVLKSNSTLEVLDLSFNRIENAGAKYLSETLTShNRSLKA 306
Cdd:COG5238   308 ------GAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEG-NTTLRE 380

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1958752077 307 LSVVSNKIEGEGLVALSQSMNTNLVLSNIYIWGNKFDE 344
Cdd:COG5238   381 LNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLIGAE 418
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 70-347 4.63e-30

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 118.23  E-value: 4.63e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077  70 LRNHPCIGGVDVRYNLIGDVGAYYAAKLLQKQPNITYLNLMFNDIG--PEGGELIAKALQKNKTLKYLRMTGNKIENTGG 147
Cdd:cd00116    19 LPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDGC 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 148 MLFAAMLQmNSSLEKLDLGDCDLGLQSVIAFSTVLTQNK-AIKGINLNRPILYGeqeESTVHIGHMLKQNHVLVELHMCK 226
Cdd:cd00116    99 GVLESLLR-SSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEG---ASCEALAKALRANRDLKELNLAN 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 227 HGMKNYGIQQLCNALHSNSTLRYLDVSCNKITRDGMVFLADVLKSNSTLEVLDLSFNRIENAGAKYLSETLTSHNRSLKA 306
Cdd:cd00116   175 NGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLT 254

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1958752077 307 LSVVSNKIEGEGLVALSQSMNTNLVLSNIYIWGNKFDEDTC 347
Cdd:cd00116   255 LSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGA 295
LRR_8 pfam13855
Leucine rich repeat;
245-314 1.15e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.15e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 245 STLRYLDVSCNKITRDGmvflADVLKSNSTLEVLDLSFNRIenagaKYLSETLTSHNRSLKALSVVSNKI 314
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD----DGAFKGLSNLKVLDLSNNLL-----TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
272-299 7.54e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 33.92  E-value: 7.54e-03
                           10        20
                   ....*....|....*....|....*...
gi 1958752077  272 NSTLEVLDLSFNRIENAGAKYLSETLTS 299
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 67-344 1.09e-34

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 133.38  E-value: 1.09e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077  67 SKALRNHPcIGGVDVRYNLIGDVGAYYAAKLLQKQPNITYLNLMFNDIGPEGGELIAKALQKNKTLKYLRMTGNKIENTG 146
Cdd:COG5238   174 AKALQNNS-VETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEG 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 147 GMLFAAMLQMNSSLEKLDLGDCDLGLQSVIAFSTVLTQNKAIKGINLNrpilygeqeestvhighmlkQNHVLVElhmck 226
Cdd:COG5238   253 VIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLS--------------------VNRIGDE----- 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 227 hgmknyGIQQLCNALHSNSTLRYLDVSCNKITRDGMVFLADVLKSNSTLEVLDLSFNRIENAGAKYLSETLTShNRSLKA 306
Cdd:COG5238   308 ------GAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEG-NTTLRE 380

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1958752077 307 LSVVSNKIEGEGLVALSQSMNTNLVLSNIYIWGNKFDE 344
Cdd:COG5238   381 LNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLIGAE 418
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 103-388 5.56e-33

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 128.75  E-value: 5.56e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 103 NITYLNLMFNDIGPEGGELIAKALQKNKTLKYLRMTGNKIENTGGMLFAAMLQMNSSLEKLDLGDCDLGLQSVIAFSTVL 182
Cdd:COG5238   181 SVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEAL 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 183 TQNKAIKGINLNrpilygeqeestvhighmlkQNHVLVElhmckhgmknyGIQQLCNALHSNSTLRYLDVSCNKITRDGM 262
Cdd:COG5238   261 KNNTTVETLYLS--------------------GNQIGAE-----------GAIALAKALQGNTTLTSLDLSVNRIGDEGA 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 263 VFLADVLKSNSTLEVLDLSFNRIENAGAKYLSETLTShNRSLKALSVVSNKIEGEGLVALSQSMNTNLVLSNIYIWGNKF 342
Cdd:COG5238   310 IALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQE-NTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNI 388

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1958752077 343 DEDTCVAYSNLIESGRLKPENTDVEPYVVDEHIYLSEVSNGLKRHY 388
Cdd:COG5238   389 GKQGAEALIDALQTNRLHTLILDGNLIGAEAQQRLEQLLERIKSVY 434
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 70-347 4.63e-30

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 118.23  E-value: 4.63e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077  70 LRNHPCIGGVDVRYNLIGDVGAYYAAKLLQKQPNITYLNLMFNDIG--PEGGELIAKALQKNKTLKYLRMTGNKIENTGG 147
Cdd:cd00116    19 LPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDGC 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 148 MLFAAMLQmNSSLEKLDLGDCDLGLQSVIAFSTVLTQNK-AIKGINLNRPILYGeqeESTVHIGHMLKQNHVLVELHMCK 226
Cdd:cd00116    99 GVLESLLR-SSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEG---ASCEALAKALRANRDLKELNLAN 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 227 HGMKNYGIQQLCNALHSNSTLRYLDVSCNKITRDGMVFLADVLKSNSTLEVLDLSFNRIENAGAKYLSETLTSHNRSLKA 306
Cdd:cd00116   175 NGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLT 254

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1958752077 307 LSVVSNKIEGEGLVALSQSMNTNLVLSNIYIWGNKFDEDTC 347
Cdd:cd00116   255 LSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGA 295
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 98-312 5.56e-23

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 98.58  E-value: 5.56e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077  98 LQKQPNITYLNLMFNDIGPEGGELIaKALQKNKTLKYLRMTGNKIENTGGMLFAAMLQMNS-SLEKLDLGDCDLGLQSVI 176
Cdd:cd00116    77 LTKGCGLQELDLSDNALGPDGCGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCE 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 177 AFSTVLTQNKAIKGINL-NRPILY------------------------GEQEESTVHIGHMLKQNHVLVELHMCKHGMKN 231
Cdd:cd00116   156 ALAKALRANRDLKELNLaNNGIGDagiralaeglkancnlevldlnnnGLTDEGASALAETLASLKSLEVLNLGDNNLTD 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 232 YGIQQLCNAL-HSNSTLRYLDVSCNKITRDGMVFLADVLKSNSTLEVLDLSFNRIENAGAKYLSETLTSHNRSLKALSVV 310
Cdd:cd00116   236 AGAAALASALlSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVK 315


                  ..
gi 1958752077 311 SN 312
Cdd:cd00116   316 DD 317
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 47-297 1.24e-21

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 96.40  E-value: 1.24e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077  47 AGNSRLD----SGQRITSEDFWLLSKALRNHPCIGGVDVRYNLIGDVGAYYAAKLLQKQPNITYLNLMFNDIGPEGGELI 122
Cdd:COG5238   233 KGNKSLTtldlSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIAL 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 123 AKALQKNKTLKYLRMTGNKIENTGGMLFAAMLQMNSSLEKLDLGDCDLGLQSVIAfstvltqnkaikginlnrpilygeq 202
Cdd:COG5238   313 AEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIA------------------------- 367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 203 eestvhighmlkqnhvlvelhmckhgmknygiqqLCNALHSNSTLRYLDVSCNKITRDGMVFLADVLKSNsTLEVLDLSF 282
Cdd:COG5238   368 ----------------------------------LAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-RLHTLILDG 412

                         250
                  ....*....|....*
gi 1958752077 283 NRIENAGAKYLSETL 297
Cdd:COG5238   413 NLIGAEAQQRLEQLL 427
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 181-355 1.86e-15

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 77.52  E-value: 1.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 181 VLTQNKAIKGIN--LNRPILYGEQEESTVHIGHMLKQNHVLVELHMCKHgMKNYGIQQLCNALHSNSTLRYLDVSCNKIT 258
Cdd:COG5238   143 LIQVLKDPLGGNavHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQ-IGDEGIEELAEALTQNTTVTTLWLKRNPIG 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 259 RDGMVFLADVLKSNSTLEVLDLSFNRIENAGAKYLSETLTsHNRSLKALSVVSNKIEGEGLVALSQSMNTNLVLSNIYIW 338
Cdd:COG5238   222 DEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALK-NNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLS 300

                         170
                  ....*....|....*..
gi 1958752077 339 GNKFDEDTCVAYSNLIE 355
Cdd:COG5238   301 VNRIGDEGAIALAEGLQ 317
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 94-356 1.06e-12

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 68.54  E-value: 1.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077  94 AAKLLQKQPNITYLNLMFNDIGPEGGELIAKALQKNKTLKYLRMTGNKIENTGGMLFAAM--LQMNSSLEKLDLGDCDLG 171
Cdd:cd00116    15 ATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLLqgLTKGCGLQELDLSDNALG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 172 LQSVIAFStvltqnkaikginlnrpilygeqeestvhighmlkqnhvlvelhmckhgmknygiqqlcnALHSNSTLRYLD 251
Cdd:cd00116    95 PDGCGVLE------------------------------------------------------------SLLRSSSLQELK 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 252 VSCNKITRDGMVFLADVLKSNS-TLEVLDLSFNRIENAGAKYLSETLtSHNRSLKALSVVSNKIEGEGLVALSQSMNTNL 330
Cdd:cd00116   115 LNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKAL-RANRDLKELNLANNGIGDAGIRALAEGLKANC 193

                         250       260
                  ....*....|....*....|....*.
gi 1958752077 331 VLSNIYIWGNKFDEDTCVAYSNLIES 356
Cdd:cd00116   194 NLEVLDLNNNGLTDEGASALAETLAS 219
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 24-194 1.25e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 65.07  E-value: 1.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077  24 LNILQKLDEEIEKR-----------PKEKITVNIAGNSRLDSGqriTSEDfwlLSKALRNHPCIGGVDVRYNLIGDVGAY 92
Cdd:cd00116   110 LQELKLNNNGLGDRglrllakglkdLPPALEKLVLGRNRLEGA---SCEA---LAKALRANRDLKELNLANNGIGDAGIR 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077  93 YAAKLLQKQPNITYLNLMFNDIGPEGGELIAKALQKNKTLKYLRMTGNKIENTGGMLFA-AMLQMNSSLEKLDLGDCDLG 171
Cdd:cd00116   184 ALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALAsALLSPNISLLTLSLSCNDIT 263

                         170       180
                  ....*....|....*....|...
gi 1958752077 172 LQSVIAFSTVLTQNKAIKGINLN 194
Cdd:cd00116   264 DDGAKDLAEVLAEKESLLELDLR 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
231-344 6.30e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 6.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 231 NYGIQQLCNALHSNSTLRYLDVSCNKITRdgmvfLADVLKSNSTLEVLDLSFNRIENagakyLSETLtSHNRSLKALSVV 310
Cdd:COG4886   145 NNQLTDLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQITD-----LPEPL-GNLTNLEELDLS 213

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958752077 311 SNKIE--GEGLVALSQsmntnlvLSNIYIWGNKFDE 344
Cdd:COG4886   214 GNQLTdlPEPLANLTN-------LETLDLSNNQLTD 242
LRR_8 pfam13855
Leucine rich repeat;
245-314 1.15e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.15e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 245 STLRYLDVSCNKITRDGmvflADVLKSNSTLEVLDLSFNRIenagaKYLSETLTSHNRSLKALSVVSNKI 314
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD----DGAFKGLSNLKVLDLSNNLL-----TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-369 2.34e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077   1 MEKLQDQYSFLCSENIRKTNPLILNILQKLDEEIEKRPKEKITVNIAGNSRLDSGQRITSEDFWLLSKALRNHPCIGGVD 80
Cdd:COG4886    23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077  81 VRYNligdvgayyaaKLLQKQPNITYLNLMFNDIgpeggELIAKALQKNKTLKYLRMTGNKIENtggmlFAAMLQMNSSL 160
Cdd:COG4886   103 LSGN-----------EELSNLTNLESLDLSGNQL-----TDLPEELANLTNLKELDLSNNQLTD-----LPEPLGNLTNL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 161 EKLDLGDCDLGlqsviAFSTVLTQNKAIKGINLNRpilygeqeestvhighmlkqNHvlvelhmckhgmknygIQQLCNA 240
Cdd:COG4886   162 KSLDLSNNQLT-----DLPEELGNLTNLKELDLSN--------------------NQ----------------ITDLPEP 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752077 241 LHSNSTLRYLDVSCNKITRdgmvfLADVLKSNSTLEVLDLSFNRIEN----AGAKYLSETLTSHNR-----------SLK 305
Cdd:COG4886   201 LGNLTNLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQLTDlpelGNLTNLEELDLSNNQltdlpplanltNLK 275

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958752077 306 ALSVVSNKIEGEGLVALSQSMNTNLVLSNIYIWGNKFDEDTCVAYSNLIESGRLKPENTDVEPY 369
Cdd:COG4886   276 TLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
272-299 7.54e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 33.92  E-value: 7.54e-03
                           10        20
                   ....*....|....*....|....*...
gi 1958752077  272 NSTLEVLDLSFNRIENAGAKYLSETLTS 299
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_6 pfam13516
Leucine Rich repeat;
271-294 8.39e-03

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 33.75  E-value: 8.39e-03
                          10        20
                  ....*....|....*....|....
gi 1958752077 271 SNSTLEVLDLSFNRIENAGAKYLS 294
Cdd:pfam13516   1 SNTHLTTLDLSDNDIGDEGAEALA 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH