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Conserved domains on  [gi|1958752576|ref|XP_038959012|]
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RWD domain-containing protein 3 isoform X2 [Rattus norvegicus]

Protein Classification

DUF1115 domain-containing protein( domain architecture ID 16521)

DUF1115 domain-containing protein similar to Saccharomyces cerevisiae C-terminal region of U4/U6 small nuclear ribonucleoprotein Prp3 which may be involved in U4/U6 reassembly after splicing

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RWDD3_C cd24164
RWD domain-containing protein 3, C-terminal domain; RWDD3, also called RSUME, is a small ...
 41-149 4.61e-53

RWD domain-containing protein 3, C-terminal domain; RWDD3, also called RSUME, is a small protein containing an N-terminal RWD domain and a C-terminal domain of unknown function. RWDD3 acts by modulating post-translational modification (PTM) of proteins, and it also plays a role in tumorigenesis. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


:

Pssm-ID: 467815  Cd Length: 110  Bit Score: 163.94  E-value: 4.61e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752576  41 LWMTLLRLDHMRARTKYVKVVEKWASELRLTGRLMFMGKMILILLQGDRSNIKEYLILQKTSKVDVDSSGKKCKEKMISV 120
Cdd:cd24164     1 LETVLLRLDHMRAKAKYVKTLKKWTQELGLTGRLIFYGKLILILLQGTSENIKKYLVRLRTEKVDVDSRGRPCKERMMTV 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958752576 121 LSETKVQT-EHKRFLAFEVKEYSTLEELQK 149
Cdd:cd24164    81 LGERKVPTcEKSGFTEFEVLEPSSLEELLV 110
 
Name Accession Description Interval E-value
RWDD3_C cd24164
RWD domain-containing protein 3, C-terminal domain; RWDD3, also called RSUME, is a small ...
 41-149 4.61e-53

RWD domain-containing protein 3, C-terminal domain; RWDD3, also called RSUME, is a small protein containing an N-terminal RWD domain and a C-terminal domain of unknown function. RWDD3 acts by modulating post-translational modification (PTM) of proteins, and it also plays a role in tumorigenesis. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467815  Cd Length: 110  Bit Score: 163.94  E-value: 4.61e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752576  41 LWMTLLRLDHMRARTKYVKVVEKWASELRLTGRLMFMGKMILILLQGDRSNIKEYLILQKTSKVDVDSSGKKCKEKMISV 120
Cdd:cd24164     1 LETVLLRLDHMRAKAKYVKTLKKWTQELGLTGRLIFYGKLILILLQGTSENIKKYLVRLRTEKVDVDSRGRPCKERMMTV 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958752576 121 LSETKVQT-EHKRFLAFEVKEYSTLEELQK 149
Cdd:cd24164    81 LGERKVPTcEKSGFTEFEVLEPSSLEELLV 110
DUF1115 pfam06544
Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical ...
 48-160 3.43e-03

Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.


Pssm-ID: 461943  Cd Length: 135  Bit Score: 35.73  E-value: 3.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752576  48 LDHMRARTKyvkvVEKWASELRLTGRLMFMGKMILILLQGDRSNIKEY--LILQ----KTSKVDVDSSGKKCKEKMISVL 121
Cdd:pfam06544   8 LSNPKHRFK----IDKNAKQLGLTGFCILGPPFGLVVVEGGEKSIKKYkkLMLRrikwTENPHEDFEAMKEITFEWDNDE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1958752576 122 SETKV----------QTEHKRFLAFEVKEYSTLEELQKEFETAGLQELF 160
Cdd:pfam06544  84 DNEGEdnkcelvwegEVKERAFRKWKFKVCETEGEAREFLKKHGVEHYW 132
 
Name Accession Description Interval E-value
RWDD3_C cd24164
RWD domain-containing protein 3, C-terminal domain; RWDD3, also called RSUME, is a small ...
 41-149 4.61e-53

RWD domain-containing protein 3, C-terminal domain; RWDD3, also called RSUME, is a small protein containing an N-terminal RWD domain and a C-terminal domain of unknown function. RWDD3 acts by modulating post-translational modification (PTM) of proteins, and it also plays a role in tumorigenesis. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467815  Cd Length: 110  Bit Score: 163.94  E-value: 4.61e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752576  41 LWMTLLRLDHMRARTKYVKVVEKWASELRLTGRLMFMGKMILILLQGDRSNIKEYLILQKTSKVDVDSSGKKCKEKMISV 120
Cdd:cd24164     1 LETVLLRLDHMRAKAKYVKTLKKWTQELGLTGRLIFYGKLILILLQGTSENIKKYLVRLRTEKVDVDSRGRPCKERMMTV 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958752576 121 LSETKVQT-EHKRFLAFEVKEYSTLEELQK 149
Cdd:cd24164    81 LGERKVPTcEKSGFTEFEVLEPSSLEELLV 110
Prp3_C-like cd24140
C-terminal domain of Prp3 and related proteins; This group contains the C-terminal domains of ...
 41-148 1.24e-34

C-terminal domain of Prp3 and related proteins; This group contains the C-terminal domains of Prp3 and RWD domain-containing proteins 2/3. Predicted structures (by AlphaFold) of the C-terminal domains of RWDD2 and RWDD3 reveal similarity to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467812  Cd Length: 117  Bit Score: 117.75  E-value: 1.24e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752576  41 LWMTLLRLDHMRARTKYVKVVEKWAsELRLTGRLMFMGKMILILLQGDRSNIKEYLILQKTSKVDVDSSGK--------K 112
Cdd:cd24140     1 YHCKVFHFKHLQNKKKRFKIKENSK-ELSLKGLCMRIRDPGIIIVVGNEKSCKEYENLVKKRKWNEDFELHtntgdikeK 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1958752576 113 CKEKMISVLSETKVQT--EHKRFLAFEVKEYSTLEELQ 148
Cdd:cd24140    80 CHNNSISKTWEGYLQDckFKGWFLKVCNDQYSLLRTLG 117
RWDD2_C cd24163
C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small ...
 50-163 7.27e-07

C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small proteins that contain an N-terminal RWD domain and a C-terminal domain of unknown function. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467814  Cd Length: 122  Bit Score: 45.71  E-value: 7.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752576  50 HMRARTKyVKVVEKWASELRLTGRLMFmGKMILILLQGDRSNIKEYL-ILQKTSKvdvdssgKKCK---EKMISVLSETK 125
Cdd:cd24163    10 HIYSKKK-RKDIVEWAKELGLTGFSKP-GKPGVICVEGDEEDVDEYVrRIRRLRW-------KKIQvrgEEVIEVPRFFG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1958752576 126 VQTEHKRFLAFEVKEYST--LEELQKEFETAGLQELFSEC 163
Cdd:cd24163    81 EEEDEERALPGGFRELHEdlMGELAAFLEEAGLEELFLTL 120
DUF1115 pfam06544
Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical ...
 48-160 3.43e-03

Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.


Pssm-ID: 461943  Cd Length: 135  Bit Score: 35.73  E-value: 3.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752576  48 LDHMRARTKyvkvVEKWASELRLTGRLMFMGKMILILLQGDRSNIKEY--LILQ----KTSKVDVDSSGKKCKEKMISVL 121
Cdd:pfam06544   8 LSNPKHRFK----IDKNAKQLGLTGFCILGPPFGLVVVEGGEKSIKKYkkLMLRrikwTENPHEDFEAMKEITFEWDNDE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1958752576 122 SETKV----------QTEHKRFLAFEVKEYSTLEELQKEFETAGLQELF 160
Cdd:pfam06544  84 DNEGEdnkcelvwegEVKERAFRKWKFKVCETEGEAREFLKKHGVEHYW 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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