NCBI Conserved Domain Search

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 211.46 E-value: 1.64e-63

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  262 GTVTEFKHPGHFYVQLYSSEVLEYMNQLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEGVDVLQKKAHV 341
Cdd:cd20408      1 GTVTEFKNPGEFYIQIYTLEVLESLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQKKAGV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958643053  342 LYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGEWTEDCV 391
Cdd:cd20408     81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 146.06 E-value: 2.77e-41

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  512 GHKLAELQESLSEYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPK 591
Cdd:cd20409      1 GRQLAELQESLSAYCKVAPASSDFSPAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPS 80


                   ..
gi 1958643053  592 LL 593
Cdd:cd20409     81 LL 82

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 140.27 E-value: 7.45e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  938 ANVLEIISPTLFYAIPSEMPENQEKLCVLTAELLEHCNAQKGQPPYRPRTGEACCAKYT--------------------- 996
Cdd:cd20411      1 ALVLEVISPDLFYALPKTGQVNVEKLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTgdknwyravvletsdsevkvl 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958643053  997 --NYGNVERLPFSRVQPITASHLQLPFRIIRCSLEG 1030
Cdd:cd20411     81 yaDYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 128.63 E-value: 9.82e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  489 DEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCSHVtPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESVL 568
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASK-PPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVE 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1958643053  569 VGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAG 606
Cdd:pfam00567   80 VLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 128.24 E-value: 1.59e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  709 ETVDVMVCMMHSPGEFYCHclKDDALKKLDDLNKSLADYCAQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGNV 788
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQ--PKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLV 78

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1958643053  789 KVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWL 825
Cdd:pfam00567   79 EVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQL 115

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 115.13 E-value: 1.10e-30

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958643053  756 FKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFL 814
Cdd:cd20410      1 FKPIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 113.60 E-value: 1.71e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  258 MEIKGTVTEFKHPGHFYVQlySSEVLEYMNQLSASLKETYANMVPEdGYLPVKGEVCVAKYTVDQTWNRAVVEgVDVLQK 337
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQ--PKSDSKKLEKLTEELQEYYASKPPE-SLPPAVGDGCVAAFSEDGKWYRAKIT-ESLDDG 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1958643053  338 KAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSG 378
Cdd:pfam00567   77 LVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 105.22 E-value: 1.71e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  514 KLAELQESLSEYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAyASEESVLVGYVDYGNFEILSLKRLCPIIPKLL 593
Cdd:cd20411     25 KLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLE-TSDSEVKVLYADYGNTETLPLSRILPITKSHL 103

                           90
                   ....*....|...
gi 1958643053  594 DLPMQALNCVLAG 606
Cdd:cd20411    104 ELPFQIIRCSLAG 116

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 96.67 E-value: 2.16e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  493 GVVAHIQTPEDFF--CQQLQSGHKLAELQESLSEYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAY-ASEESVLV 569
Cdd:cd20408      1 GTVTEFKNPGEFYiqIYTLEVLESLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVdVQQKKAGV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958643053  570 GYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGMWTPEAI 619
Cdd:cd20408     81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 92.55 E-value: 4.83e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  483 LTLNVGDEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCSHvtpRSDFYPTIGDMCCAQFSEDDQWYRASVLAYA 562
Cdd:cd20439      4 YLFKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSLMKQIQSYYLI---HNDPYKHGQIACVAKYSKDGKWYRAAVLKQV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1958643053  563 SEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGV 607
Cdd:cd20439     81 SAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 89.83 E-value: 4.24e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  271 GHFYVQLYSSEVLE-YMNQLSA-SLKETYAnmvPEDGYLPVKGEVCVAKYTVDQTWNRAVV-----EGVDVLQKKAHVLY 343
Cdd:cd20443      2 GRFYVQVVSDQRLSsIQQQLEGlSLKDKAN---PPGGFNPKKGELVLAQFSADNSWNRAMVvnaprQGTQSPKDEYEVFY 78

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1958643053  344 IDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGV-VP 381
Cdd:cd20443     79 IDYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAHIkVP 117

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 87.12 E-value: 3.40e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  720 SPGEFYC-HCLKDDALKKLDDLNKSLADYC-AQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSgNVKVHFVDYGN 797
Cdd:cd20411      8 SPDLFYAlPKTGQVNVEKLKALMTELAEYCsKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLETSDS-EVKVLYADYGN 86

                           90       100
                   ....*....|....*....|....*...
gi 1958643053  798 VEEVTTDQLHAIAPQFLLLPFQGMQCWL 825
Cdd:cd20411     87 TETLPLSRILPITKSHLELPFQIIRCSL 114

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 83.96 E-value: 5.98e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  720 SPGEFYCHCLKDDALKKLDDLNKSLAD-YCAQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGN-VKVHFVDYGN 797
Cdd:cd20408      8 NPGEFYIQIYTLEVLESLVKLTSQLKKtYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQKkAGVFYIDYGN 87

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1958643053  798 VEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKHWTKEA 839
Cdd:cd20408     88 EETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEEC 129

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 84.09 E-value: 6.87e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  493 GVVAHIQTPEDFFCQQlqSGHKLAELQESLSEYCSHVTPRSDFYPTI--GDMCCAQFSEDDQWYRASVLAYASEEsVLVG 570
Cdd:cd20426      3 AYATAVDSPEYFWCQF--ATEKIQCLAVKVQEAGEQVADRGNFIPSIyvGDPCIVKYSEDNHWYRALVTKINDNL-VSVR 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1958643053  571 YVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGMWTPEA 618
Cdd:cd20426     80 FVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEA 127

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 81.19 E-value: 1.56e-18

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958643053  286 MNQLSaslKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEGVDVlQKKAHVLYIDYGNEEIIPVDRIHQL 360
Cdd:cd20433      9 MEKLR---FEIASNPPLPGSYTPRKGDLCAAKFVEDGEWYRAKVEKVEG-DKKVHVLYIDYGNREVLPSTRLAAL 79

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 75.41 E-value: 2.02e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  735 KKLDDLNKSLADYCAQKPPNGFKAE--VGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQ 812
Cdd:cd20412      4 LQLDKLVQEMTQYYESEENRHTLLTvqVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALRSD 83

                           90
                   ....*....|.
gi 1958643053  813 FLLLPFQGMQC 823
Cdd:cd20412     84 FLSLPFQAIEC 94

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 74.64 E-value: 3.44e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  511 SGHKLAELQESL-SEYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPII 589
Cdd:cd20433      1 TGPQLEKLMEKLrFEIASNPPLPGSYTPRKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALP 80


                   .
gi 1958643053  590 P 590
Cdd:cd20433     81 P 81

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 74.81 E-value: 8.23e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  505 FCQQLQSGHKLAELQESLSEYC--SHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVL------AYASEESVLVGYVDYGN 576
Cdd:cd20443      4 FYVQVVSDQRLSSIQQQLEGLSlkDKANPPGGFNPKKGELVLAQFSADNSWNRAMVVnaprqgTQSPKDEYEVFYIDYGN 83

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1958643053  577 FEILSLKRLCPIIPKLLDLPMQALNCVLAGVKP 609
Cdd:cd20443     84 QETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 71.39 E-value: 1.78e-15

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958643053  760 VGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAI 809
Cdd:cd20379      1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 74.03 E-value: 1.99e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  713 VMVCMMHSPGEFYCHCLKDDALkkLDDLNKSLADYCAQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHF 792
Cdd:cd20440     14 VYITHVYSPAKFYCQLDRNTEI--LEALMEKIAEISKLFNSQILDNCKTRLCLAKYFEDGQWYRALAHPVESSSHLSVYF 91

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958643053  793 VDYGNVEEVTTDQLHAI---APQFLLLPFQGMQCWL 825
Cdd:cd20440     92 VDYGNKQIVEKNEVLPIpdtAVDLLLTPMQAIKCCL 127

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 72.84 E-value: 3.49e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  707 VDETVDVMVCMMHSPGEFYCHCLKDDalKKLDDLNKSLADYCAQKppngfKAEVGRPC------CACFAGDGNWYRALVK 780
Cdd:cd20437      1 VGTTEKVKITAAVSPSKFYCQLLSWE--PELSKLTTQMTLHYESV-----SKELNPSCenfgllCAAKGKDGQWHRGFLQ 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1958643053  781 EILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWL 825
Cdd:cd20437     74 QLLPPSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 70.06 E-value: 5.67e-15

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958643053  535 FYPTIGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKLL 593
Cdd:cd20410      1 FKPIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 71.18 E-value: 5.70e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  736 KLDDLNKSLADYCAQKPPNG--FKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQF 813
Cdd:cd20433      4 QLEKLMEKLRFEIASNPPLPgsYTPRKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALPPAF 83

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 69.47 E-value: 9.26e-15

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958643053  539 IGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPI 588
Cdd:cd20379      1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 71.75 E-value: 1.09e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  705 FTVDETVDVMVCMMHSPGEFYCHCLKDdaLKKLDDLNKSLADYCAqkppngFKAEVGRPC-CACFA---GDGNWYRALVK 780
Cdd:cd20439      6 FKPGSVVDVKCSYVNSPGDFWCQLQTK--SSELKSLMKQIQSYYL------IHNDPYKHGqIACVAkysKDGKWYRAAVL 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1958643053  781 EILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDI 828
Cdd:cd20439     78 KQVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 69.82 E-value: 1.50e-14

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958643053  543 CCAQFSEDDQWYRASVL-AYASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLG 612
Cdd:cd20423      9 CLAKYSEDGKWCRALIDnVYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSG 79

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 69.41 E-value: 5.85e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  711 VDVMVCMMHSPGEFYCHCLKDDALKKL--DDLN--KSLADYCAQKPPNgfkaeVGRPCCACFAGDGNWYRALVKEILPSG 786
Cdd:cd20425      2 TEVYVSHVNSPSDFYVQLAQDEDELSMisEKLNasKANDEEVECESLQ-----LGDLICAEYPEDGLWYRAVVKEKIPNN 76

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1958643053  787 NVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWL 825
Cdd:cd20425     77 LVSVQFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 69.85 E-value: 6.31e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  712 DVMVCMMHSPGEFYCHcLKDDALKkLDDLNKSLAD-YCAQKPPNGF--KAEVGRPCCACFAGDGnWYRALVKEILPSGnV 788
Cdd:cd20422      3 DAQVEFVKDPSEFWIR-LGEHAVP-FSKLMRSMTAfYSQASKLDGVvlKPQPGQLCCAKWKEDR-YYRAIVTAVKGKM-V 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958643053  789 KVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKHWTKEATARFQ 844
Cdd:cd20422     79 EVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFK 134

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 68.92 E-value: 7.90e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  934 KTVPANVLEIISPTLFYAIPSEmpeNQEKLCVLTAELLEHCNaQKGQPPYRPRTGEACCAKYTN---------------- 997
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKS---DSKKLEKLTEELQEYYA-SKPPESLPPAVGDGCVAAFSEdgkwyrakiteslddg 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1958643053  998 --------YGNVERLPFSRVQPITASHLQLPFRIIRCSLEG 1030
Cdd:pfam00567   77 lvevlfidYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 68.23 E-value: 7.98e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  515 LAELQEslsEYCSHVTPRSDFY-PTIGDMCCAQFsEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKLL 593
Cdd:cd20415      5 TKKIQE---FYKEGDDGGLEILcPVQGQACVALF-EDGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFL 80

                           90
                   ....*....|....*.
gi 1958643053  594 DLPMQALNCVLAGVKP 609
Cdd:cd20415     81 SLPEKARECRLAFIEP 96

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 69.02 E-value: 8.97e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  495 VAHIQTPEDFFCQQLQSGHKLAELQESLSEYcSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDY 574
Cdd:cd20440     16 ITHVYSPAKFYCQLDRNTEILEALMEKIAEI-SKLFNSQILDNCKTRLCLAKYFEDGQWYRALAHPVESSSHLSVYFVDY 94

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1958643053  575 GNFEILSLKRLCPI---IPKLLDLPMQALNCVL 604
Cdd:cd20440     95 GNKQIVEKNEVLPIpdtAVDLLLTPMQAIKCCL 127

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 69.43 E-value: 1.15e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  757 KAEVGRPCCACFAGDGNWYRALVKEILpSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKHWT 836
Cdd:cd20438     54 KPEPGLLCCARYSKDRHYYRAVITEVL-DLKVSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWT 132


                   ....*...
gi 1958643053  837 KEATARFQ 844
Cdd:cd20438    133 KNANDFFK 140

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 68.20 E-value: 1.19e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  533 SDFYPtigDM-CCAQFSeDDQWYRASVLAYASEESV--LVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKP 609
Cdd:cd20418      2 TDFRP---EMpCLAEYS-DGKWYRAKLLSILEFNPVkiLVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKP 77

                           90       100
                   ....*....|....*....|....
gi 1958643053  610 SLGM-----------WTPEAICVM 622
Cdd:cd20418     78 PLNDseteripycpeWSMKALWAM 101

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 68.63 E-value: 1.19e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  264 VTEFKHPGHFY-VQLYSSEVLEYMNQLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVegVDVLQKKAHVL 342
Cdd:cd20411      3 VLEVISPDLFYaLPKTGQVNVEKLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTGDKNWYRAVV--LETSDSEVKVL 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958643053  343 YIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSG 378
Cdd:cd20411     81 YADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 66.71 E-value: 1.71e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  736 KLDDLNKSLADYCAQKPPN-GFKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFL 814
Cdd:cd20409      3 QLAELQESLSAYCKVAPASsDFSPAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPSLL 82

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 68.31 E-value: 2.13e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  491 FC-GVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCSHVTPRSDFY--PTIGDMCCAQFsEDDQWYRASVLAyASEESV 567
Cdd:cd20422      1 FYdAQVEFVKDPSEFWIRLGEHAVPFSKLMRSMTAFYSQASKLDGVVlkPQPGQLCCAKW-KEDRYYRAIVTA-VKGKMV 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958643053  568 LVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGMWTPEAICVMRK 624
Cdd:cd20422     79 EVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFKR 135

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 67.10 E-value: 2.96e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  495 VAHIQTPEDFFCQQLQSGHKLAELQESLSEYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDY 574
Cdd:cd20425      6 VSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVECESLQLGDLICAEYPEDGLWYRAVVKEKIPNNLVSVQFIDY 85

                           90       100       110
                   ....*....|....*....|....*....|
gi 1958643053  575 GNFEILSLKRLCPIIPKLLDLPMQALNCVL 604
Cdd:cd20425     86 GNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 65.39 E-value: 7.01e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  514 KLAELQESLSEYCSHVTPRSDF-YPTIGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKL 592
Cdd:cd20412      5 QLDKLVQEMTQYYESEENRHTLlTVQVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALRSDF 84

                           90
                   ....*....|
gi 1958643053  593 LDLPMQALNC 602
Cdd:cd20412     85 LSLPFQAIEC 94

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 64.81 E-value: 7.89e-13

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958643053  760 VGRPCCACFAGDGNWYRALVKEI-LPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQP 830
Cdd:cd20423      5 PNPVCLAKYSEDGKWCRALIDNVyEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQ 76

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 66.75 E-value: 8.75e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  720 SPGEFYCHClkddALKKLDDLNKSLADYCAQKPPNGFKA---EVGRPCCACFAGDGNWYRALVKEIlPSGNVKVHFVDYG 796
Cdd:cd20426     10 SPEYFWCQF----ATEKIQCLAVKVQEAGEQVADRGNFIpsiYVGDPCIVKYSEDNHWYRALVTKI-NDNLVSVRFVDYG 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1958643053  797 NVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKHWTKEATARF 843
Cdd:cd20426     85 NEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYF 131

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 64.04 E-value: 1.35e-12

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958643053  313 VCVAKYTVDQTWNRAVVEGVDVLQKKAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAG 384
Cdd:cd20423      8 VCLAKYSEDGKWCRALIDNVYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSG 79

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 63.30 E-value: 1.37e-12

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958643053  310 KGEVCVAKYTVDQTWNRAVVEGVDvLQKKAHVLYIDYGNEEIIPVDRIHQL 360
Cdd:cd20379      1 VGDLCAAKYEEDGKWYRARVLEVL-SNDKVEVFFVDYGNTETVPLSDLRPL 50

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 65.96 E-value: 1.78e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  493 GVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCSHVTPRSDFY--PTIGDMCCAQFSEDDQWYRAsVLAYASEESVLVG 570
Cdd:cd20438      9 AFVEYVLNPSNFWIRTDEYNNEFQALMKNIADIYNLCGNDEELLkkPEPGLLCCARYSKDRHYYRA-VITEVLDLKVSVY 87

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958643053  571 YVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGMWTPEAICVMRK 624
Cdd:cd20438     88 FLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWTKNANDFFKK 141

MYND finger;

Pssm-ID: 460312 Cd Length: 39 Bit Score: 61.67 E-value: 3.20e-12

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958643053  162 CHRCGLFGS--LRCSQCKQTYYCSTACQRRDWSSHSTIC 198
Cdd:pfam01753    1 CAVCGKEALklLRCSRCKSVYYCSKECQKADWPYHKKEC 39

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 64.45 E-value: 3.56e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  485 LNVGDEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCSHVTP-RSDFYPtiGDMCCAQFSeDDQWYRASVLayAS 563
Cdd:cd20424      8 IKIGSEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRLSSEIRKlELSVNP--GTLCLAKYS-DQHWYRGIII--TN 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1958643053  564 EESVLVGYVDYGNFEILSLKRLCPI---IPKLLDLPMQALNCVL 604
Cdd:cd20424     83 KNSTEVFFVDYGNTEKVEKEDMLPIpsdAYELLLLPMQAIKCSL 126

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 64.75 E-value: 3.71e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  704 EFTVDETVDVMVCMMHSPGEFYCH--CLKddalKKLDDLNKSLADYCAQKPPNGFKA---EVGRPCCACfAGDGNWYRAL 778
Cdd:cd20421      6 QLQVGVTETVVVTEVTDPHRIFCQlrSLS----QELKRLSESMHQYYEGRVGSGYETrpeKLGSPCAAR-GSDGRWYRAV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958643053  779 VKEILPSGN-VKVHFVDYGNVEEVTTDQLHAIAPQFLLLP 817
Cdd:cd20421     81 LQQVFSANRvVEVLHVDYGRKEVVSVSNLRYLAPEYFRMP 120

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 63.61 E-value: 4.52e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  501 PEDFFCQQLQSGHKLAELQESLSEYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEIL 580
Cdd:cd20441      2 PSRFFIQLSEDEKVILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGNTAVV 81

                           90       100
                   ....*....|....*....|....*..
gi 1958643053  581 SLKRLCPIIPKLLDLPMQALNCVLAGV 607
Cdd:cd20441     82 DKSNIYTLQEKFLSLPRLSIPCSLSGV 108

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 62.31 E-value: 5.52e-12

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958643053  518 LQESLSEYCSHVTPRSDfYPTIGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKL 592
Cdd:cd20430      1 LSDELAEVCPTAPPLFG-TPDPNKIYGGKFSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETVSRSSIVELPPDL 74

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 62.84 E-value: 8.50e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  720 SPGEFYCHCLKDDA--LKKLDDLNkSLADYCAQKPPNgfKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGN 797
Cdd:cd20441      1 SPSRFFIQLSEDEKviLQLAEELN-ETSEKSRENAAV--KLKVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGN 77

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958643053  798 VEEVTTDQLHAIAPQFLLLPFQGMQCWLVDI 828
Cdd:cd20441     78 TAVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 61.07 E-value: 1.38e-11

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958643053  764 CCACFAGDGnWYRALVKEILPSGN-VKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQP 830
Cdd:cd20407     10 ICAAPVMNA-WYRAQVVGVFEETDeVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 62.91 E-value: 1.50e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  712 DVMVCMMHSPGEFYCHCLKDDALkkLDDLNKSLADYCAQKPPNGFKAEVGRPCCACFAgDGNWYRALVKEILPsgNVKVH 791
Cdd:cd20424     15 EVYITYVNDPWTFYCQLARNAGV--LDQLASAISRLSSEIRKLELSVNPGTLCLAKYS-DQHWYRGIIITNKN--STEVF 89

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1958643053  792 FVDYGNVEEVTTDQLHAI---APQFLLLPFQGMQCWL 825
Cdd:cd20424     90 FVDYGNTEKVEKEDMLPIpsdAYELLLLPMQAIKCSL 126

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 61.32 E-value: 1.70e-11

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958643053  286 MNQLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEGVdVLQKKAHVLYIDYGNEEIIPVDRIHQLSRSI 364
Cdd:cd20409      4 LAELQESLSAYCKVAPASSDFSPAVGEVCCAQFTEDNQWYRASVLAY-SSEDSVLVGYIDFGNSEEVALSRLRPIPPSL 81

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 61.29 E-value: 2.16e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  518 LQESLSEYCSH-VTPRSDFYPTIGDMCCAQfSEDDQWYRASVLAyASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLP 596
Cdd:cd20427      3 MEDEMKEFYSKsSTAMCLRSPSVGQLVAVK-AEEDAWLRAQVIE-VEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLP 80

                           90
                   ....*....|...
gi 1958643053  597 MQALNCVLAGVKP 609
Cdd:cd20427     81 FQATKCKLAGLEP 93

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 60.08 E-value: 1.63e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  940 VLEIISPTLFYAIPsEMPENQEKLCVLTAELLEHCNAQKGQPPYRPRTGEACCAKYT----------------------- 996
Cdd:cd20408      3 VTEFKNPGEFYIQI-YTLEVLESLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSedqnwyralvqtvdvqqkkagvf 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958643053  997 --NYGNVERLPFSRVQPITASHLQLPFRIIRCSLEGLTELNGS 1037
Cdd:cd20408     82 yiDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGS 124

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 57.67 E-value: 1.63e-10

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958643053   537 PTIGDMCCAQFsEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKL 592
Cdd:smart00333    3 FKVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 56.51 E-value: 3.37e-10

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1958643053   759 EVGRPCCACFaGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQF 813
Cdd:smart00333    4 KVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 57.30 E-value: 3.44e-10

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958643053  743 SLADYCAQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQF 813
Cdd:cd20430      4 ELAEVCPTAPPLFGTPDPNKIYGGKFSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETVSRSSIVELPPDL 74

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 59.28 E-value: 5.15e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  261 KGTVTEFKHPGHFYVQLY-SSEVLEYMNQLSASLKETYANMVPEDgylPVKGEVCVAKYTVDQTWNRAVVEGVDVLQKKA 339
Cdd:cd20442      5 KGTLLSVSKNGTFYVRLLrNSEQLTDLESLIAKEAKKCKFVPVED---IKEGLECLAKSKKNLKWYRAVVEHLYPETEKM 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1958643053  340 HVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKC 374
Cdd:cd20442     82 LVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLC 116

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 58.59 E-value: 5.33e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  494 VVAHIQTPEDFFCQQLQSGHKLAELQESLSEY--CSHVTPRSDFYPTIGDMCCAQfSEDDQWYRASVL-AYASEESVLVG 570
Cdd:cd20421     16 VVTEVTDPHRIFCQLRSLSQELKRLSESMHQYyeGRVGSGYETRPEKLGSPCAAR-GSDGRWYRAVLQqVFSANRVVEVL 94

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958643053  571 YVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAG 606
Cdd:cd20421     95 HVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 56.06 E-value: 9.38e-10

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958643053  539 IGDMCCAQFseDDQWYRASVLAYASE-ESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKP 609
Cdd:cd20407      7 VGVICAAPV--MNAWYRAQVVGVFEEtDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 56.69 E-value: 1.46e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  495 VAHIQTPEDF---FCQQLQS---GHKLAELQESLS-EYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESV 567
Cdd:cd20419      2 VEYIESPSQFyvrFYSKDTSemlEDMMIEMRRCYSnEHVSERYVMPEAFIQPGQVCCVRIPEDVWWYRVIIHQVLNKQEV 81

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1958643053  568 LVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVL 604
Cdd:cd20419     82 EVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 56.70 E-value: 1.75e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  270 PGHFYVQLYSSEVLeyMNQLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEgvdvlQKKA----HVLYID 345
Cdd:cd20425     12 PSDFYVQLAQDEDE--LSMISEKLNASKANDEEVECESLQLGDLICAEYPEDGLWYRAVVK-----EKIPnnlvSVQFID 84

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958643053  346 YGNEEIIPVDRIHQLSRSISLFPPSAIKCYV 376
Cdd:cd20425     85 YGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 56.74 E-value: 2.38e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  260 IKGTVTEFKHPGHFYVQLYSSEV--LEYMNQLSASLKETYANMVPEdgylPVKGEVCVAKYTVDQTWNRAVVEGVDvlQK 337
Cdd:cd20426      1 IEAYATAVDSPEYFWCQFATEKIqcLAVKVQEAGEQVADRGNFIPS----IYVGDPCIVKYSEDNHWYRALVTKIN--DN 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958643053  338 KAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGEWTEDCV 391
Cdd:cd20426     75 LVSVRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEAN 128

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 56.30 E-value: 2.56e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  715 VCMMHSPGEFYCHCLKDDALKKLDDLNKSLADYCAQK------PPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGNV 788
Cdd:cd20419      2 VEYIESPSQFYVRFYSKDTSEMLEDMMIEMRRCYSNEhvseryVMPEAFIQPGQVCCVRIPEDVWWYRVIIHQVLNKQEV 81

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1958643053  789 KVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWL 825
Cdd:cd20419     82 EVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 56.68 E-value: 3.11e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  712 DVMVCMMHSPGEFYCHcLKDDALKKLDDLNKSLADY--CAQKPPNGFkaeVGRPCCA--C-FAGDGNWYRALVKEILPSG 786
Cdd:cd20428      3 NVRVTNVCSDGTLYCQ-VPSKGLSKLNEILDKIEYYfhSRQMTSEYF---VSLPFCGkiClARYKGKWARVEITNVHSSR 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958643053  787 NVKVHFVDYGNVEEVTTDQLHAIAPQFL----LLPFQGMQCWLVDIQPKNKHWTKEA 839
Cdd:cd20428     79 ALDVHFLDTGTVASVKVSELREIPPPFLreliSIPPQALKCCLADLPLNIGMWTPDA 135

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 55.98 E-value: 4.13e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  261 KGTVTEFKHPGHFYVQLYSSEVleYMNQLSASLKETYANMVPEDGYL--PVKGEVCVAKYTvDQTWNRAVVegVDVLQKK 338
Cdd:cd20422      3 DAQVEFVKDPSEFWIRLGEHAV--PFSKLMRSMTAFYSQASKLDGVVlkPQPGQLCCAKWK-EDRYYRAIV--TAVKGKM 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958643053  339 AHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGEWTEDCVVAVK 395
Cdd:cd20422     78 VEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFK 134

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 55.14 E-value: 9.08e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  505 FCQQLQSG-HKLAELQESLSEYCSHVTPRSDFY---PTIGDMCCAQFSedDQWYRASVLAYASEESVLVGYVDYG---NF 577
Cdd:cd20428     16 YCQVPSKGlSKLNEILDKIEYYFHSRQMTSEYFvslPFCGKICLARYK--GKWARVEITNVHSSRALDVHFLDTGtvaSV 93

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1958643053  578 EILSLKRLCPIIPK-LLDLPMQALNCVLAGVKPSLGMWTPEAICVMR 623
Cdd:cd20428     94 KVSELREIPPPFLReLISIPPQALKCCLADLPLNIGMWTPDAVLWLR 140

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 52.66 E-value: 9.48e-09

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1958643053   308 PVKGEVCVAKYTvDQTWNRAVVEGVDVlQKKAHVLYIDYGNEEIIPVDRIHQL 360
Cdd:smart00333    3 FKVGDKVAARWE-DGEWYRARIVKVDG-EQLYEVFFIDYGNEEVVPPSDLRQL 53

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 53.59 E-value: 1.29e-08

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958643053  760 VGRPCCACFAgDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQP 830
Cdd:cd20415     27 QGQACVALFE-DGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410500 Cd Length: 91 Bit Score: 53.26 E-value: 1.35e-08

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958643053  771 DGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGM 821
Cdd:cd20429     41 ENNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLIEKFRQLPFQAI 91

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 53.21 E-value: 1.90e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  270 PGHFYVQLYSSE-----VLEYMNQLSASLKETYANMvpedgylPVKGEVCVAKYTVDQTWNRAVVEgvDVL-QKKAHVLY 343
Cdd:cd20441      2 PSRFFIQLSEDEkvilqLAEELNETSEKSRENAAVK-------LKVGDLVAAEYDEDLALYRAVIT--AVLpGKSFKVEF 72

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958643053  344 IDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGV 379
Cdd:cd20441     73 IDYGNTAVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 53.19 E-value: 3.28e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  492 CGVVAHIQ-----TPEDFFCQQLQSGHKLAELQESLSEYCSHVTPRSDfyPTI---GDMCCAQfSEDDQWYRASVLAYAS 563
Cdd:cd20437      1 VGTTEKVKitaavSPSKFYCQLLSWEPELSKLTTQMTLHYESVSKELN--PSCenfGLLCAAK-GKDGQWHRGFLQQLLP 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1958643053  564 EESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLA 605
Cdd:cd20437     78 PSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLS 119

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 53.02 E-value: 4.59e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  760 VGRPC----CACFAGDGNWYRALVKEILPSG------NVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQ 829
Cdd:cd20435     47 HGKVKvgdlCAVEDENNLYHRVKVLEITEKDdktkprEVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVK 126


                   ....*...
gi 1958643053  830 P--KNKHW 835
Cdd:cd20435    127 PvdNDTEW 134

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 52.64 E-value: 5.30e-08

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958643053  537 PTIGDMCCAQfSEDDQWYRASVLAYASEES------VLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKP 609
Cdd:cd20435     50 VKVGDLCAVE-DENNLYHRVKVLEITEKDDktkpreVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKP 127

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 50.42 E-value: 5.61e-08

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958643053  306 YLPVKGEVCVAKYTVDQTWNRAVVEgvDVLQK-KAHVLYIDYGNEEIIPVDRIHQLS 361
Cdd:cd20410      1 FKPIVGEPCCAFFSGDGNWYRAMVK--EILPGgAVKVHFVDYGNVEEVTLDKLRKIT 55

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 52.86 E-value: 5.89e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  270 PGHFYVQlysseVLEYMNQLSASLK---ETYANMVPEDGYL--PVKGEVCVAKYTVDQTWNRAVVegVDVLQKKAHVLYI 344
Cdd:cd20438     17 PSNFWIR-----TDEYNNEFQALMKniaDIYNLCGNDEELLkkPEPGLLCCARYSKDRHYYRAVI--TEVLDLKVSVYFL 89

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1958643053  345 DYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGEWTE 388
Cdd:cd20438     90 DFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWTK 133

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.

Pssm-ID: 410469 Cd Length: 56 Bit Score: 49.96 E-value: 7.46e-08

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958643053  539 IGDMCCAQFSEDDQWYRASVLA-YASEESVLVGYVDYGNFEILSLKRLCPIIPK 591
Cdd:cd20398      3 VGDKCRAVYSEDGIIYEATIVSiDAERGTCVVRYTGYGNEEEQNLSDLLPPSGE 56

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 49.56 E-value: 8.37e-08

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958643053  311 GEVCVAKYTVDQTWNRAVVEGVDVLQKKAHVLYIDYGNEEIIPVDRIHQL 360
Cdd:cd21182      1 GDKCLAPYSDDGKYYEATIEEITEESDTATVVFDGYGNSEEVPLSDLKPL 50

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 51.68 E-value: 1.03e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  264 VTEFKHPGHFYVQLYSSEVLEYMNQLSASLKETYANMVPEDGY-LP----VKGEVCVAKYTVDQTWNRAVVegVDVL-QK 337
Cdd:cd20419      2 VEYIESPSQFYVRFYSKDTSEMLEDMMIEMRRCYSNEHVSERYvMPeafiQPGQVCCVRIPEDVWWYRVII--HQVLnKQ 79

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1958643053  338 KAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKC 374
Cdd:cd20419     80 EVEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPA 116

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 49.17 E-value: 1.37e-07

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958643053  540 GDMCCAQFSEDDQWYRASVLA-YASEESVLVGYVDYGNFEILSLKRLCPI 588
Cdd:cd21182      1 GDKCLAPYSDDGKYYEATIEEiTEESDTATVVFDGYGNSEEVPLSDLKPL 50

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 52.35 E-value: 1.38e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  514 KLAELQESLSEYCSHV---TPRSDFYPTI----GDMCCAQFSEDDQWYRASVL-AYASEESVLVGYVDYGNFEILSL--- 582
Cdd:cd20442     20 RLLRNSEQLTDLESLIakeAKKCKFVPVEdikeGLECLAKSKKNLKWYRAVVEhLYPETEKMLVFFVDHGITEVVSMgni 99

                           90       100
                   ....*....|....*....|
gi 1958643053  583 KRLCpiiPKLLDLPMQALNC 602
Cdd:cd20442    100 KQLS---NDLLQIPRQAVLC 116

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 51.26 E-value: 1.56e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  262 GTVTEFK-----HPGHFYVQLYSSEV-LEYMNQLSASLKETYAN-MVPEDGYLpvkGEVCVAKYTvDQTWNRAVVEGVdV 334
Cdd:cd20437      2 GTTEKVKitaavSPSKFYCQLLSWEPeLSKLTTQMTLHYESVSKeLNPSCENF---GLLCAAKGK-DGQWHRGFLQQL-L 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958643053  335 LQKKAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVS 377
Cdd:cd20437     77 PPSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLS 119

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 50.54 E-value: 2.62e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  722 GEFYchcLKDDALKKLDDLNKSLADYCAQK---PPNGFKAEVGRPCCACFAGDGNWYRALVKE------ILPSGNVKVHF 792
Cdd:cd20443      2 GRFY---VQVVSDQRLSSIQQQLEGLSLKDkanPPGGFNPKKGELVLAQFSADNSWNRAMVVNaprqgtQSPKDEYEVFY 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1958643053  793 VDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQP 830
Cdd:cd20443     79 IDYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 49.33 E-value: 4.19e-07

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958643053  762 RPCCACFA--GDGNWYRALVKEILPSGNVK--VHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKN 832
Cdd:cd20418      5 RPEMPCLAeySDGKWYRAKLLSILEFNPVKilVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPL 79

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 47.30 E-value: 5.56e-07

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958643053  308 PVKGEVCVAKYtvDQTWNRAVVEGVDVLQKKAHVLYIDYGNEEIIPVDRIHQLS 361
Cdd:cd20444      1 PTPGQMVIAKF--DGNHYRAIVLRVLNPDLKILVRFVDFGNVEVMKLENLYECP 52

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 49.41 E-value: 7.61e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  262 GTVTEFK-----HPGHFYVQLY--SSEVLEYMNQLSaSLKETYANMvpedgYLPvkGEV-CVAKYTVDQTWNRAVVEGVd 333
Cdd:cd20439      9 GSVVDVKcsyvnSPGDFWCQLQtkSSELKSLMKQIQ-SYYLIHNDP-----YKH--GQIaCVAKYSKDGKWYRAAVLKQ- 79

                           90
                   ....*....|....*..
gi 1958643053  334 VLQKKAHVLYIDYGNEE 350
Cdd:cd20439     80 VSAKEVDVIFVDYGNQE 96

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 49.04 E-value: 9.45e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  264 VTEFKHPGHFYVQL-YSSEVLEYMNQLSASLKETYANMVpedgyLPVK-GEVCVAKYTvDQTWNRAVVegvDVLQKKAHV 341
Cdd:cd20424     18 ITYVNDPWTFYCQLaRNAGVLDQLASAISRLSSEIRKLE-----LSVNpGTLCLAKYS-DQHWYRGII---ITNKNSTEV 88

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958643053  342 LYIDYGNEEIIPVDRIHQL---SRSISLFPPSAIKC 374
Cdd:cd20424     89 FFVDYGNTEKVEKEDMLPIpsdAYELLLLPMQAIKC 124

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 47.29 E-value: 1.02e-06

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958643053  308 PVKGEVCVAKYTVDQTWNRAVVEGVDVlQKKAHVLYIDYGNEEIIPVDRIHQLS 361
Cdd:cd20430     19 PDPNKIYGGKFSEDNCWYRCKVKSILS-DEKCTVQYIDYGNTETVSRSSIVELP 71

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 48.96 E-value: 1.12e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  263 TVTEFKHPGHFYVQL--YSSEVleymNQLSASLKETY-ANMVPEDGYLPVK-GEVCVAKyTVDQTWNRAVVEGVDVLQKK 338
Cdd:cd20421     16 VVTEVTDPHRIFCQLrsLSQEL----KRLSESMHQYYeGRVGSGYETRPEKlGSPCAAR-GSDGRWYRAVLQQVFSANRV 90

                           90       100
                   ....*....|....*....|...
gi 1958643053  339 AHVLYIDYGNEEIIPVDRIHQLS 361
Cdd:cd20421     91 VEVLHVDYGRKEVVSVSNLRYLA 113

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410470 [Multi-domain] Cd Length: 55 Bit Score: 46.53 E-value: 1.25e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1958643053  760 VGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQL 806
Cdd:cd20399      3 VGDKCMAVWSEDGQYYEATIEEISEDGTCTVTFDGYGNTEVTPLSQL 49

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 46.09 E-value: 1.30e-06

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958643053  761 GRPCCACFAGDGNWYRALVKEILPSGN-VKVHFVDYGNVEEVTTDQLHAI 809
Cdd:cd21182      1 GDKCLAPYSDDGKYYEATIEEITEESDtATVVFDGYGNSEEVPLSDLKPL 50

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 47.42 E-value: 1.65e-06

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958643053  766 ACFAGDGNWYRALVKEIlPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQP 830
Cdd:cd20427     30 AVKAEEDAWLRAQVIEV-EEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQATKCKLAGLEP 93

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 45.76 E-value: 1.93e-06

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958643053  537 PTIGDMCCAQFseDDQWYRASVL-AYASEESVLVGYVDYGNFEILSLKRL--CP 587
Cdd:cd20444      1 PTPGQMVIAKF--DGNHYRAIVLrVLNPDLKILVRFVDFGNVEVMKLENLyeCP 52

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 47.07 E-value: 4.33e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  264 VTEFKHPGHFYVQLYSSEvlEYMNQLSASLKEtYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEGVDVLQkKAHVLY 343
Cdd:cd20440     16 ITHVYSPAKFYCQLDRNT--EILEALMEKIAE-ISKLFNSQILDNCKTRLCLAKYFEDGQWYRALAHPVESSS-HLSVYF 91

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1958643053  344 IDYGNEEIIPVDR---IHQLSRSISLFPPSAIKCY 375
Cdd:cd20440     92 VDYGNKQIVEKNEvlpIPDTAVDLLLTPMQAIKCC 126

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 47.25 E-value: 4.34e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  269 HPGHFYVQL-----YSSEVLEYMN----QLSASLKETYA---NMVPEDgyLPVKGEVCVAKYTvDQTWNRAVVEGV---- 332
Cdd:cd20435      1 DATHYSARIlehrsSDGEVTKSMSstylKLSMKLNMYYSdpsNRILHG--KVKVGDLCAVEDE-NNLYHRVKVLEItekd 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958643053  333 -DVLQKKAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVP 381
Cdd:cd20435     78 dKTKPREVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKP 127

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 46.23 E-value: 5.49e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  497 HIQTPEDFFCQQ--LQSGHKLAELQESLSEYcSHVTPRSDFYPTigDMCCAQFSEDDQ--WYRASVLaYASEESVLVGYV 572
Cdd:cd20431      2 EVVEVGHFWGYRidENSSEILQQLTAEINQR-QLVPLTTKPVPN--LLCLAPFTDADMkkYYRAKIL-YVSGSSAEVFFV 77

                           90       100
                   ....*....|....*....|....
gi 1958643053  573 DYGNFEILSLKRLCPIIPKLLDLP 596
Cdd:cd20431     78 DYGNTSQVPSSLLREIPETLLTLP 101

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 45.12 E-value: 1.20e-05

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958643053  306 YLPVKGEVCVAKYTvDQTWNRAVVEGVdVLQKKAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKC 374
Cdd:cd20415     23 LCPVQGQACVALFE-DGAWYRARIIGL-PGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKAREC 89

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 45.07 E-value: 1.29e-05

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958643053  752 PPNGFkaevgrpCCACFA-GDGN-WYRALVKEILPSgNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLP 817
Cdd:cd20431     42 VPNLL-------CLAPFTdADMKkYYRAKILYVSGS-SAEVFFVDYGNTSQVPSSLLREIPETLLTLP 101

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 44.37 E-value: 1.36e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  961 EKLCVLTAELLEHCNAQKGQPPYRPRTGEACCAKYT------------------------NYGNVERLPFSRVQPITASH 1016
Cdd:cd20409      2 RQLAELQESLSAYCKVAPASSDFSPAVGEVCCAQFTednqwyrasvlayssedsvlvgyiDFGNSEEVALSRLRPIPPSL 81


                   .
gi 1958643053 1017 L 1017
Cdd:cd20409     82 L 82

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 43.48 E-value: 1.49e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1958643053  760 VGRPCCACFAGDGNWYRALVKEILPSGNVK-VHFVDYGNVEEV 801
Cdd:cd20413      3 PGDECLAKYWEDNKFYRAEVTAVHPSGKTAvVKFMEYGNYEEV 45

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 42.96 E-value: 1.59e-05

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958643053  768 FAGDGNWYRALVKEILPSGNVKVHFvDYGNVEEVTTDQL 806
Cdd:cd04508      8 WSDDGQWYPATVVAVNDDGKYTVLF-DDGNEEEVSEDDI 45

Tudor domain found in Tudor domain-containing protein 10 (TDRD10) and similar proteins; TDRD10 is widely expressed and localized both to the nucleus and cytoplasm, and may play general roles like regulation of RNA metabolism. It contains a Tudor domain and an RNA recognition motif (RRM). The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410503 Cd Length: 139 Bit Score: 45.50 E-value: 2.26e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  246 FSDLRSLQLrkSMEIKGT----VTE-FKHPGHFYVQLYSSEVLEYMNQLSASLketyANMVPEDGYLP----VKGEVCVA 316
Cdd:cd20432      6 FGDLSWLAS--IMKVHGEvgllVTDtFPHTPYFWAILLTEESQQNMQQLFSTL----AEVESQQPFLAkedvHRGRRCLA 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1958643053  317 KYTVDQ---TWNRAVVegVDVLQKKAHVLYIDYGNEEIIPVDRIHQLS 361
Cdd:cd20432     80 ECPLGEeggAWNRCWV--LDVVEDFAVVFFVDFGSTANIPLPSLRSLD 125

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 44.32 E-value: 2.91e-05

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958643053  314 CVAKYTvDQTWNRAVVEGVDVLQK-KAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGE 385
Cdd:cd20418     10 CLAEYS-DGKWYRAKLLSILEFNPvKILVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPLND 81

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 45.10 E-value: 3.55e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  539 IGDMCCAQFSEDDQWYRASVLAyASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGMWTPEA 618
Cdd:cd20436     49 VGEFCLVEDTTSGEWYRGRVLE-KIDEKYEVFLIDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIGEKWSSTA 127


                   .
gi 1958643053  619 I 619
Cdd:cd20436    128 V 128

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 45.10 E-value: 3.55e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  311 GEVCVAKYTVDQTWNRAVVegVDVLQKKAHVLYIDYGNEEIipVDRIHQLSRSISLF--PPSAIKCYVSGVVPAAGEWTE 388
Cdd:cd20436     50 GEFCLVEDTTSGEWYRGRV--LEKIDEKYEVFLIDRGEVLN--VHATNMASASGELFqlPPKAVCGIFANILPIGEKWSS 125

                           90
                   ....*....|....*
gi 1958643053  389 DCVVAVKALLFEQYC 403
Cdd:cd20436    126 TAVNYFSSLIGSQVK 140

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410470 [Multi-domain] Cd Length: 55 Bit Score: 42.29 E-value: 3.86e-05

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958643053  538 TIGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCP 587
Cdd:cd20399      2 KVGDKCMAVWSEDGQYYEATIEEISEDGTCTVTFDGYGNTEVTPLSQLKP 51

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 43.53 E-value: 4.91e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  265 TEFKHPGHFYVQLYSSEVLEYMNQLSASLKE-TYANMVPEdgylPVKGEVCVAKYT--VDQTWNRAVVegVDVLQKKAHV 341
Cdd:cd20431      1 TEVVEVGHFWGYRIDENSSEILQQLTAEINQrQLVPLTTK----PVPNLLCLAPFTdaDMKKYYRAKI--LYVSGSSAEV 74

                           90
                   ....*....|...
gi 1958643053  342 LYIDYGNEEIIPV 354
Cdd:cd20431     75 FFVDYGNTSQVPS 87

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 41.56 E-value: 6.20e-05

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958643053  310 KGEVCVAKYTVDQTWNRAVVEGVDVLQKKAHVLYIDYGNEEIIPVDRIHQL 360
Cdd:cd20413      3 PGDECLAKYWEDNKFYRAEVTAVHPSGKTAVVKFMEYGNYEEVLLSDIKPI 53

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410455 Cd Length: 55 Bit Score: 41.06 E-value: 8.96e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1958643053  765 CACFA--GDGNWYRALVKEILPSGNVKVHFVDYGNVEEVttdQLHAIAP 811
Cdd:cd20384      9 SRCLAkyDDGLWYPATVTDIDEDGKYTVKFDSYGEVAVV---ELDDILP 54

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 41.42 E-value: 1.27e-04

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958643053  311 GEVCVAkyTVDQTWNRAVVEGVDVLQKKAHVLYIDYGNEEIIPVDRIHQLsRSISL-FPPSAIKCYVSGVVP 381
Cdd:cd20407      8 GVICAA--PVMNAWYRAQVVGVFEETDEVEIKYLDYGGYERVPVDDLRQI-RSDFMtLPFQATECYLANIEP 76

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 41.64 E-value: 1.72e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  288 QLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVegVDVLQKKAHVLYIDYGNEEIIPVDRIHQLSRSISLF 367
Cdd:cd20427      2 QMEDEMKEFYSKSSTAMCLRSPSVGQLVAVKAEEDAWLRAQV--IEVEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSL 79

                           90
                   ....*....|....
gi 1958643053  368 PPSAIKCYVSGVVP 381
Cdd:cd20427     80 PFQATKCKLAGLEP 93

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 40.02 E-value: 2.43e-04

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958643053  540 GDMCCAQFSEDDQWYRASVLAYASEESV-LVGYVDYGNFEILSLKRLCPI 588
Cdd:cd20413      4 GDECLAKYWEDNKFYRAEVTAVHPSGKTaVVKFMEYGNYEEVLLSDIKPI 53

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 39.11 E-value: 3.53e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1958643053  540 GDMCCAQFSEDDQWYRASVLAYASEESVLVGYvDYGNFEILSLKRLCP 587
Cdd:cd04508      1 GDRVEAKWSDDGQWYPATVVAVNDDGKYTVLF-DDGNEEEVSEDDIRP 47

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 39.33 E-value: 4.35e-04

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958643053  312 EVCVAKYtvDQTWNRAV-VEGVDvlQKKAHVLYIDYGNEEIIPVDrihqlsrSISLFPPSAIK 373
Cdd:cd20445      3 ELCIAKY--MDKWYRAVcLESVG--DGRPTVLFCDYGNILMARLT-------DIRPFPPTFAT 54

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410488 Cd Length: 68 Bit Score: 38.96 E-value: 8.60e-04

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  765 CACFAGDGNWYRALVKEILpSGNVKVHFVDYGNVEEVTTDQLHAIA-----PQFlLLPFQ 819
Cdd:cd20417      7 CVVRGSDTLWYRGKVLEVI-GGMVRVQYVDQGYIEKIPQCHLYPMVlypdiPQF-CIPCQ 64

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410500 Cd Length: 91 Bit Score: 39.39 E-value: 9.79e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  507 QQLQSGHKLAELQESLSEYCSHVTPRSdfyPTIG--DMCCAQFseDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKR 584
Cdd:cd20429      1 QPWQELHKLEVLMEEMILYYNKTEERP---VAIEknKVYAAKI--ENNWYRVLVKGILTNGLVSVYELDYGKHELVSIRK 75

                           90
                   ....*....|....*.
gi 1958643053  585 LCPIIPKLLDLPMQAL 600
Cdd:cd20429     76 VQPLIEKFRQLPFQAI 91

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 38.44 E-value: 9.82e-04

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958643053  771 DGNWYRALVKEIL-PSGNVKVHFVDYGNVEEVTTDQL 806
Cdd:cd20444     12 DGNHYRAIVLRVLnPDLKILVRFVDFGNVEVMKLENL 48

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 37.79 E-value: 1.71e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1958643053  772 GNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLP 817
Cdd:cd20445     11 DKWYRAVCLESVGDGRPTVLFCDYGNILMARLTDIRPFPPTFATEP 56

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 36.80 E-value: 3.11e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1958643053  311 GEVCVAKYTVDQTWNRAVVEGVDvLQKKAHVLYiDYGNEEIIPVDRI 357
Cdd:cd04508      1 GDRVEAKWSDDGQWYPATVVAVN-DDGKYTVLF-DDGNEEEVSEDDI 45

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 38.05 E-value: 3.73e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  289 LSASLKETYANMVPEDGYLPVK-GEVCVAKYTVDQTWNRAVVEGVdVLQKKAHVLYIDYGNEEIIPVDRIHQLsRS--IS 365
Cdd:cd20412      9 LVQEMTQYYESEENRHTLLTVQvGDIVAAPFRHDGSWYRARVLGF-LENGNLDLYFVDYGDSGYVPLEDLRAL-RSdfLS 86


                   ....*....
gi 1958643053  366 LfPPSAIKC 374
Cdd:cd20412     87 L-PFQAIEC 94

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 38.19 E-value: 7.98e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  263 TVTEFKHPGHFYVQLYS------SEVLEYMNQLSASLKETYANMVPedgyLPVKGEVCVAKYTvdQTWNRavVEGVDVLQ 336
Cdd:cd20428      5 RVTNVCSDGTLYCQVPSkglsklNEILDKIEYYFHSRQMTSEYFVS----LPFCGKICLARYK--GKWAR--VEITNVHS 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643053  337 KKA-HVLYIDYGNEEIIPVDRIH----QLSRSISLFPPSAIKCYVSGVVPAAGEWTEDCV 391
Cdd:cd20428     77 SRAlDVHFLDTGTVASVKVSELReippPFLRELISIPPQALKCCLADLPLNIGMWTPDAV 136

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.

Pssm-ID: 410469 Cd Length: 56 Bit Score: 35.71 E-value: 8.67e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958643053  759 EVGRPCCACFAGDGNWYRALVKEI-LPSGNVKVHFVDYGNVEEV 801
Cdd:cd20398      2 KVGDKCRAVYSEDGIIYEATIVSIdAERGTCVVRYTGYGNEEEQ 45

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410487 Cd Length: 82 Bit Score: 36.31 E-value: 9.05e-03

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958643053  289 LSASLKETYANMVPEdgylPVKGEV---CVAKYTVDQTWNRAVVEGVdVLQKKAHVLYIDYGNEEIIPVDRIHQLSRSI 364
Cdd:cd20416      1 LQEKMIAEYENSKPE----PVKWENdmhCAVQIQDKKQWRRGQIIRV-VSDTLVEVFLYDFGNKEVVNIDCLRKLEENL 74