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Conserved domains on  [gi|1958754407|ref|XP_038959561|]
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protocadherin-10 isoform X1 [Rattus norvegicus]

Protein Classification

protocadherin( domain architecture ID 11175748)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 19-101 5.68e-39

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 139.20  E-value: 5.68e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407   19 QLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARRFQTVANSRTPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVF 98
Cdd:pfam08266    1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                   ...
gi 1958754407   99 LEN 101
Cdd:pfam08266   81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 254-354 1.33e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.73  E-value: 1.33e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  254 VYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSShisPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDL 333
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS---GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1958754407  334 GPNAVPAHCKVLVRVLDANDN 354
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 590-680 1.61e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 1.61e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  590 LPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRLDWRTGELRTARRVPakRDPQRPYELVIEVRDHGQPPLS 669
Cdd:cd11304      6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLD--REEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|.
gi 1958754407  670 STATLVVQLVD 680
Cdd:cd11304     84 STATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 467-570 1.99e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.99e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  467 VYDVYVTENNVPGAYIYAVSATDRDEGANAKLTYSILECQIQGmsvftYVSINSDNGYLYALRSFDYEQIKDFSFQVEAR 546
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....
gi 1958754407  547 DAGSPQaLAGNATVNILIVDQNDN 570
Cdd:cd11304     76 DGGGPP-LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 367-459 3.09e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 3.09e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  367 VSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVP---FRLKSsfkNYYTIVTEAPLDREAGDSYTLTVVARDRGEPAL 443
Cdd:cd11304      6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1958754407  444 STSKSIQVQVSDVNDN 459
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 128-246 9.24e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 9.24e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  128 TVEISESATPGTRFPLESAFDPDVGTNSLRDYEIT---PNSYFSLDVQTqgdgnrfAELVLEKPLDREQQAVHRYVLTAV 204
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDPST-------GEITTAKPLDREEQSSYTLTVTAT 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1958754407  205 DggggggggegggggggvglPPQQQRTGTALLTIRVLDSNDN 246
Cdd:cd11304     76 D-------------------GGGPPLSSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 713-838 6.96e-18

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 79.11  E-value: 6.96e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  713 DLTLILIIALGSVSFIFLLAMIVL-AVRCQKEKKLNIYTClasdcclcccccgngsstccgrqararkkklsksdimlvq 791
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLiALRLRRWRSSALLQS---------------------------------------- 40

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1958754407  792 SANVPSNPTqVPVEESGGFGSHHhnQNYCYQVCLTPESAKTDLMFLK 838
Cdd:pfam16492   41 SGNLCSVPA-PHFPGNDGTGTLP--QSYSYEVCLTSDSGKSEFKFLK 84
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 19-101 5.68e-39

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 139.20  E-value: 5.68e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407   19 QLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARRFQTVANSRTPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVF 98
Cdd:pfam08266    1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                   ...
gi 1958754407   99 LEN 101
Cdd:pfam08266   81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 254-354 1.33e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.73  E-value: 1.33e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  254 VYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSShisPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDL 333
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS---GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1958754407  334 GPNAVPAHCKVLVRVLDANDN 354
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 590-680 1.61e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 1.61e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  590 LPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRLDWRTGELRTARRVPakRDPQRPYELVIEVRDHGQPPLS 669
Cdd:cd11304      6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLD--REEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|.
gi 1958754407  670 STATLVVQLVD 680
Cdd:cd11304     84 STATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 467-570 1.99e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.99e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  467 VYDVYVTENNVPGAYIYAVSATDRDEGANAKLTYSILECQIQGmsvftYVSINSDNGYLYALRSFDYEQIKDFSFQVEAR 546
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....
gi 1958754407  547 DAGSPQaLAGNATVNILIVDQNDN 570
Cdd:cd11304     76 DGGGPP-LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 367-459 3.09e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 3.09e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  367 VSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVP---FRLKSsfkNYYTIVTEAPLDREAGDSYTLTVVARDRGEPAL 443
Cdd:cd11304      6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1958754407  444 STSKSIQVQVSDVNDN 459
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 273-356 1.29e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 89.72  E-value: 1.29e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407   273 NATDPDEGQNGEVVYSFSShisPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDAN 352
Cdd:smart00112    1 SATDADSGENGKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1958754407   353 DNAP 356
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
590-678 1.60e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.05  E-value: 1.60e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  590 LPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRLDWRTGELRTARRVpaKRDPQRPYELVIEVRDHGQPPLS 669
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL--DRESIGEYELTVEATDSGGPPLS 82


                   ....*....
gi 1958754407  670 STATLVVQL 678
Cdd:pfam00028   83 STATVTITV 91
Cadherin pfam00028
Cadherin domain;
255-349 6.31e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.13  E-value: 6.31e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  255 YTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRareLFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLG 334
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG---NFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1958754407  335 PNAVPAHCKVLVRVL 349
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 486-572 1.22e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 1.22e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407   486 SATDRDEGANAKLTYSILecqiQGmSVFTYVSINSDNGYLYALRSFDYEQIKDFSFQVEARDAGSPQaLAGNATVNILIV 565
Cdd:smart00112    1 SATDADSGENGKVTYSIL----SG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP-LSSTATVTITVL 74


                    ....*..
gi 1958754407   566 DQNDNAP 572
Cdd:smart00112   75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 381-461 5.31e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.09  E-value: 5.31e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407   381 SVTDRDSEENGQVQCELLGDVPFRLkssFK---NYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVN 457
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGL---FSidpETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1958754407   458 DNAP 461
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 605-680 8.64e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 8.64e-20
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958754407   605 AVDADDGENARLTYSIVRGNEMNLFRLDWRTGELRTARRVpaKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPL--DREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 128-246 9.24e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 9.24e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  128 TVEISESATPGTRFPLESAFDPDVGTNSLRDYEIT---PNSYFSLDVQTqgdgnrfAELVLEKPLDREQQAVHRYVLTAV 204
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDPST-------GEITTAKPLDREEQSSYTLTVTAT 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1958754407  205 DggggggggegggggggvglPPQQQRTGTALLTIRVLDSNDN 246
Cdd:cd11304     76 D-------------------GGGPPLSSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 713-838 6.96e-18

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 79.11  E-value: 6.96e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  713 DLTLILIIALGSVSFIFLLAMIVL-AVRCQKEKKLNIYTClasdcclcccccgngsstccgrqararkkklsksdimlvq 791
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLiALRLRRWRSSALLQS---------------------------------------- 40

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1958754407  792 SANVPSNPTqVPVEESGGFGSHHhnQNYCYQVCLTPESAKTDLMFLK 838
Cdd:pfam16492   41 SGNLCSVPA-PHFPGNDGTGTLP--QSYSYEVCLTSDSGKSEFKFLK 84
Cadherin pfam00028
Cadherin domain;
468-564 3.25e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.64  E-value: 3.25e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  468 YDVYVTENNVPGAYIYAVSATDRDEGANAKLTYSILECQIQGMsvFTyvsINSDNGYLYALRSFDYEQIKDFSFQVEARD 547
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN--FR---IDPDTGDISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 1958754407  548 AGSPqALAGNATVNILI 564
Cdd:pfam00028   76 SGGP-PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
367-453 4.26e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.56  E-value: 4.26e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  367 VSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRlksSFK-NYYT--IVTEAPLDREAGDSYTLTVVARDRGEPAL 443
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG---NFRiDPDTgdISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|
gi 1958754407  444 STSKSIQVQV 453
Cdd:pfam00028   82 SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 145-248 1.04e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 1.04e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407   145 SAFDPDVGTNSLRDYEITPNS---YFSLDVQTQgdgnrfaELVLEKPLDREQQAVHRYVLTAVDGGggggggeggggggg 221
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNddgLFSIDPETG-------EITTTKPLDREEQPEYTLTVEATDGG-------------- 59

                            90       100
                    ....*....|....*....|....*..
gi 1958754407   222 vglppQQQRTGTALLTIRVLDSNDNVP 248
Cdd:smart00112   60 -----GPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 21-118 1.10e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.25  E-value: 1.10e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407   21 HYTVQEEQEHGTFVGNI-AEDLglDITKLSARRFQTVANSRTPYLDLNLETGVLYVNEKIDREQIckqspsCVLHLEVFL 99
Cdd:cd11304      3 EVSVPENAPPGTVVLTVsATDP--DSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTA 74

                           90       100
                   ....*....|....*....|....
gi 1958754407  100 ENPLELFR-----VEIEVLDINDN 118
Cdd:cd11304     75 TDGGGPPLsstatVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
128-241 4.76e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.84  E-value: 4.76e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  128 TVEISESATPGTRFPLESAFDPDVGTNSLRDYEIT---PNSYFSLDVQTQgdgnrfaELVLEKPLDREQQAVHRYVLTAV 204
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEAT 74

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1958754407  205 DGGggggggegggggggvglppQQQRTGTALLTIRVL 241
Cdd:pfam00028   75 DSG-------------------GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 52-120 1.48e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.18  E-value: 1.48e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958754407    52 RFQTVANSRTPYLDLNLETGVLYVNEKIDREQICkqspscVLHLEVFLENPLELFR-----VEIEVLDINDNPP 120
Cdd:smart00112   14 TYSILSGNDDGLFSIDPETGEITTTKPLDREEQP------EYTLTVEATDGGGPPLsstatVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 19-101 5.68e-39

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 139.20  E-value: 5.68e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407   19 QLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARRFQTVANSRTPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVF 98
Cdd:pfam08266    1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                   ...
gi 1958754407   99 LEN 101
Cdd:pfam08266   81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 254-354 1.33e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.73  E-value: 1.33e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  254 VYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSShisPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDL 333
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS---GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1958754407  334 GPNAVPAHCKVLVRVLDANDN 354
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 590-680 1.61e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 1.61e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  590 LPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRLDWRTGELRTARRVPakRDPQRPYELVIEVRDHGQPPLS 669
Cdd:cd11304      6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLD--REEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|.
gi 1958754407  670 STATLVVQLVD 680
Cdd:cd11304     84 STATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 467-570 1.99e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.99e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  467 VYDVYVTENNVPGAYIYAVSATDRDEGANAKLTYSILECQIQGmsvftYVSINSDNGYLYALRSFDYEQIKDFSFQVEAR 546
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....
gi 1958754407  547 DAGSPQaLAGNATVNILIVDQNDN 570
Cdd:cd11304     76 DGGGPP-LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 367-459 3.09e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 3.09e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  367 VSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVP---FRLKSsfkNYYTIVTEAPLDREAGDSYTLTVVARDRGEPAL 443
Cdd:cd11304      6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1958754407  444 STSKSIQVQVSDVNDN 459
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 273-356 1.29e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 89.72  E-value: 1.29e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407   273 NATDPDEGQNGEVVYSFSShisPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDAN 352
Cdd:smart00112    1 SATDADSGENGKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1958754407   353 DNAP 356
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
590-678 1.60e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.05  E-value: 1.60e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  590 LPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRLDWRTGELRTARRVpaKRDPQRPYELVIEVRDHGQPPLS 669
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL--DRESIGEYELTVEATDSGGPPLS 82


                   ....*....
gi 1958754407  670 STATLVVQL 678
Cdd:pfam00028   83 STATVTITV 91
Cadherin pfam00028
Cadherin domain;
255-349 6.31e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.13  E-value: 6.31e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  255 YTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRareLFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLG 334
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG---NFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1958754407  335 PNAVPAHCKVLVRVL 349
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 486-572 1.22e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 1.22e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407   486 SATDRDEGANAKLTYSILecqiQGmSVFTYVSINSDNGYLYALRSFDYEQIKDFSFQVEARDAGSPQaLAGNATVNILIV 565
Cdd:smart00112    1 SATDADSGENGKVTYSIL----SG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP-LSSTATVTITVL 74


                    ....*..
gi 1958754407   566 DQNDNAP 572
Cdd:smart00112   75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 381-461 5.31e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.09  E-value: 5.31e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407   381 SVTDRDSEENGQVQCELLGDVPFRLkssFK---NYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVN 457
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGL---FSidpETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1958754407   458 DNAP 461
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 605-680 8.64e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 8.64e-20
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958754407   605 AVDADDGENARLTYSIVRGNEMNLFRLDWRTGELRTARRVpaKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPL--DREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 128-246 9.24e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 9.24e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  128 TVEISESATPGTRFPLESAFDPDVGTNSLRDYEIT---PNSYFSLDVQTqgdgnrfAELVLEKPLDREQQAVHRYVLTAV 204
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDPST-------GEITTAKPLDREEQSSYTLTVTAT 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1958754407  205 DggggggggegggggggvglPPQQQRTGTALLTIRVLDSNDN 246
Cdd:cd11304     76 D-------------------GGGPPLSSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 713-838 6.96e-18

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 79.11  E-value: 6.96e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  713 DLTLILIIALGSVSFIFLLAMIVL-AVRCQKEKKLNIYTClasdcclcccccgngsstccgrqararkkklsksdimlvq 791
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLiALRLRRWRSSALLQS---------------------------------------- 40

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1958754407  792 SANVPSNPTqVPVEESGGFGSHHhnQNYCYQVCLTPESAKTDLMFLK 838
Cdd:pfam16492   41 SGNLCSVPA-PHFPGNDGTGTLP--QSYSYEVCLTSDSGKSEFKFLK 84
Cadherin pfam00028
Cadherin domain;
468-564 3.25e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.64  E-value: 3.25e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  468 YDVYVTENNVPGAYIYAVSATDRDEGANAKLTYSILECQIQGMsvFTyvsINSDNGYLYALRSFDYEQIKDFSFQVEARD 547
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN--FR---IDPDTGDISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 1958754407  548 AGSPqALAGNATVNILI 564
Cdd:pfam00028   76 SGGP-PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
367-453 4.26e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.56  E-value: 4.26e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  367 VSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRlksSFK-NYYT--IVTEAPLDREAGDSYTLTVVARDRGEPAL 443
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG---NFRiDPDTgdISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|
gi 1958754407  444 STSKSIQVQV 453
Cdd:pfam00028   82 SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 145-248 1.04e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 1.04e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407   145 SAFDPDVGTNSLRDYEITPNS---YFSLDVQTQgdgnrfaELVLEKPLDREQQAVHRYVLTAVDGGggggggeggggggg 221
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNddgLFSIDPETG-------EITTTKPLDREEQPEYTLTVEATDGG-------------- 59

                            90       100
                    ....*....|....*....|....*..
gi 1958754407   222 vglppQQQRTGTALLTIRVLDSNDNVP 248
Cdd:smart00112   60 -----GPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 21-118 1.10e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.25  E-value: 1.10e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407   21 HYTVQEEQEHGTFVGNI-AEDLglDITKLSARRFQTVANSRTPYLDLNLETGVLYVNEKIDREQIckqspsCVLHLEVFL 99
Cdd:cd11304      3 EVSVPENAPPGTVVLTVsATDP--DSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTA 74

                           90       100
                   ....*....|....*....|....
gi 1958754407  100 ENPLELFR-----VEIEVLDINDN 118
Cdd:cd11304     75 TDGGGPPLsstatVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
128-241 4.76e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.84  E-value: 4.76e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407  128 TVEISESATPGTRFPLESAFDPDVGTNSLRDYEIT---PNSYFSLDVQTQgdgnrfaELVLEKPLDREQQAVHRYVLTAV 204
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEAT 74

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1958754407  205 DGGggggggegggggggvglppQQQRTGTALLTIRVL 241
Cdd:pfam00028   75 DSG-------------------GPPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 22-118 9.33e-07

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 48.11  E-value: 9.33e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958754407   22 YTVQEEQEHGTFVGNIAEDLGlditKLSARRFQTVA--NSRTP-YLDLNLETGVLYVNEKIDREQIckqspsCVLHLEVF 98
Cdd:cd00031      4 GSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAagKEALPsWLHWEPHSGILEGLEKLDREDK------GVHYISVS 73

                           90       100
                   ....*....|....*....|....*
gi 1958754407   99 L-----ENPLELFRVEIEVLDINDN 118
Cdd:cd00031     74 AaslgaNVPQTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 52-120 1.48e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.18  E-value: 1.48e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958754407    52 RFQTVANSRTPYLDLNLETGVLYVNEKIDREQICkqspscVLHLEVFLENPLELFR-----VEIEVLDINDNPP 120
Cdd:smart00112   14 TYSILSGNDDGLFSIDPETGEITTTKPLDREEQP------EYTLTVEATDGGGPPLsstatVTITVLDVNDNAP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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