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Conserved domains on  [gi|1958769650|ref|XP_038963564|]
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Fanconi anemia group D2 protein homolog isoform X1 [Rattus norvegicus]

Protein Classification

fanconi anemia group D2 protein( domain architecture ID 11235073)

fanconi anemia group D2 protein (FANCD2) is required for maintenance of chromosomal stability, promotion of accurate and efficient pairing of homologs during meiosis, and the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing

Gene Ontology:  GO:0006281|GO:0031573|GO:1990918|GO:0070182

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FancD2 pfam14631
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
 38-1420 0e+00

Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.


:

Pssm-ID: 464225  Cd Length: 1346  Bit Score: 2343.24  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650   38 SCGSHEVEENGSVFVRLLKASGLTLKTGDNQNQLGVDQIIFQRKLFQALRKHPSYPKVIEEFVNGLESYTEDIDSLRNCL 117
Cdd:pfam14631    1 SHAQNEVEENGSVFVKLLKTAGVILKTGENQNEIAVDQVIFQKKLQQALRKHPSYPKVIEEFITGLESYIEDRDTFRNCL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  118 LSCERLQDEEA-SMGTFYSKSLIKLLLGIDILQPAIIKMLFEKVPQFLFESESRDGISMPRLIISQLKWLDRIVDSKDLT 196
Cdd:pfam14631   81 LPCVPLQSEEAsSMVTSYQESLIKLLLGIEILQPAIIKTLFEKLPEFMFESVNSDGLNMPRLIINQLKWLDRIVDGKDLT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  197 TQMMQLISVAPVNLQHDFITSLPEILGDSQHANVGKELSELLVQNTSLTVPILDVFSSLRLDPNFLSEIRQLVMGKLSSV 276
Cdd:pfam14631  161 SKLMQLISVAPVELQHDIITSLPEILEDSQHNDVARELSSLLVENTQLTVPILDALSSLNLDPTLLSEVRQAVMGTLSAV 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  277 RLEDLPVIVKFILHSVTDSTSLEVIAELREKLNVQHFTLPSRIQASQSKLKSKGLASSSGNQENSDKDCIVLLFDVIKSA 356
Cdd:pfam14631  241 QLEDLPVVVKFILHSVSATDAYEVISELRKKLDLEQCVLPPVLQASQSKLKSKGAASSSGNQASSSQDCISLVFDVIKSA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  357 IRYEKTISEAWIKAIERIQSAAEHKALDVAMLLIIYGTSTQTKKGVERLLRNKIQSDCIQEQLLDSTFSTHCLVLKDICP 436
Cdd:pfam14631  321 VRFQKTISEAWLKAIENIDSVSDHKVLDLLMLFIIYSTNANQKKGIERVLRNKVRSGCIQEQLLQSTFRTHALVLRDYFP 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  437 SILLLAQTLFHSQDQRIILFGSLLCKYAFKFFDTYCQQEVVGALVTHVCSGNEAEVDAALDVLLELIVLNASAMRLNAAF 516
Cdd:pfam14631  401 SILALAQSLLHSPDQSIVSFGSHMYKYAFTAFDSYCQQEVVGALVTHVCSGNEAEVDVALELLLELVVLKPSAMRLYAVF 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  517 IKGILDYLENMSPQQIRKIFCILSTLAFSQQPGTSNHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAEDRTmPS 596
Cdd:pfam14631  481 VKGILDYMDNLTPQQIRKLFHILSTLAFSQQHEQSSHIQDDMHIVIRKQLSSTVPKYKRIGIIGAVTMVGSMAADRS-KS 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  597 NSTQRSASVSSEQHTQVTSLLQLVHSCTEHSPWASSLYYDEFANLIQERKLAPKTLEWVAQTIFNDFQDAFVVDFCAVPE 676
Cdd:pfam14631  560 GSSSQSASLSKEQCRQVTSLLELVHSCSEQSPQAAALYYDELANLIQKGKLDPKVLEWIGQSVLNDFQDDFVVDLGPDIE 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  677 GDFPFPVKALYGLEECNTQDGIVINLLPLFF-QEFAKDVSQVTSQESSQKSMSPLCLASHFRLLRLCVARQHNGNLDEID 755
Cdd:pfam14631  640 GDFPFPVKALYGLEEEESQGGIAINLLPLLAkDEQAKDEGEVTAQEKGQKRVSPLCLSPFFRLLRLCVEKQHDGDLEEID 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  756 ALLDCPLFLPDLEPGEKLESMSAKDRSLMCSLTFLTFNWFREVVNAFCQQTSPEMKGKVLSRLKDLVELQEILEKYLAVI 835
Cdd:pfam14631  720 GLLGCPLILTDLEVGEKLESLSKKEREFLCSLLFHTINWFREVVNAFCQQKDPEMKGKVLTRLQNITELQSLLEKYLAVT 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  836 PDYVPPFTSVDLDTLDviprsnsavaaksrhkgktggkkqkadsstasctdtllTEDTSECDVAPSGKSQVDKESTGKEG 915
Cdd:pfam14631  800 PGYVPPLANFDLDSSQ--------------------------------------KEEASEAEESQSEKSQLEKEFKGKEG 841

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  916 KTFVSLQNYRAFFRELDIEVFSILHSGLVTKFILDTEMHTEATEVVQLGPAELLFLLEDLSQKLENRLTPSFTKRVCFFK 995
Cdd:pfam14631  842 KTGVSLQSYRAFFRELDIEVFSVLHCGLLTKSLLDTEMHTKAREEVQLGPAELLFLLEDLSRKLEFMLTPAPAKRAPFLK 921

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  996 NKGSRNIGFSHLHQRSVQDIVHCVVQLLTPMCNHLENIHNFFQCLGAENLSVNDKARVTAQEHYTMSSCYQKLLQVFHAL 1075
Cdd:pfam14631  922 GKGDRNVGFSHLQQRSAQEIAHCVVQLLPPLCNHLENIHNYFQCLLAENHGVVDGPGVDVQEHQLMSSCYQLLLQVLHTL 1001

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1076 LAWKGFTHQSNHRLLRSALEVLASRLKQTEEGQPLEELLSQSFSYLQNLQHSIPSFQCGLYLLRLLMALLEKSAVPTQKK 1155
Cdd:pfam14631 1002 FAWSGFSQPENRSLLKSALGVLAGRLKEGEAELTLEELVSHSFEYLQNFRSSVPSFQCALCLIQLLIVIAEKSGNPAAKR 1081

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1156 EKLASLAKQLLCRAW--PHGDKEKNPTFNDHLHDLLCIYLEHTDNVLKAIEEITGVGVPELVNAPKDASSSTFPTLTRHT 1233
Cdd:pfam14631 1082 EKIASLARQFLCQVWvtPSGEKEKGNKFNDALHTLLCIYLEHTDDVLKAIEEIAGEGVPELINSSKDASSSTFPTLTRQT 1161

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1234 FVIFFRVMMAELEKTVKGLQAGTATDSQQVHEEKLLYWNMAVRDFSILINLMKVFDSYPVLHVCLKYGRRFVEAFLKQCM 1313
Cdd:pfam14631 1162 FLVFFRVMMAELEKSVRKIQPGTASDSQEVQEEKLLYWNMAVRDFHILVNLVKVFDSRPVLHVCLKYGRLFVEAFLKLGM 1241

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1314 PLLDFSFRKHRDDVLSLLQTLQLNTRLLHHLCGHSKIHQDTRLTKHVPLLKKSLELLVCRVKAMLVLNNCREAFWLGTLK 1393
Cdd:pfam14631 1242 PLLDFSFKKHREDVQSLLKTFQLSTRQLHHMCGHSKIHQDTGLTNHVPLLKKSLELFVYRVKAMLVLNNCQEAFWLGNLK 1321

                         1370      1380
                   ....*....|....*....|....*..
gi 1958769650 1394 NRDLQGEEIISQhpSSPENTSEDSEDG 1420
Cdd:pfam14631 1322 NRDLQGEEILSQ--RSQESDEEEEEDS 1346
 
Name Accession Description Interval E-value
FancD2 pfam14631
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
 38-1420 0e+00

Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.


Pssm-ID: 464225  Cd Length: 1346  Bit Score: 2343.24  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650   38 SCGSHEVEENGSVFVRLLKASGLTLKTGDNQNQLGVDQIIFQRKLFQALRKHPSYPKVIEEFVNGLESYTEDIDSLRNCL 117
Cdd:pfam14631    1 SHAQNEVEENGSVFVKLLKTAGVILKTGENQNEIAVDQVIFQKKLQQALRKHPSYPKVIEEFITGLESYIEDRDTFRNCL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  118 LSCERLQDEEA-SMGTFYSKSLIKLLLGIDILQPAIIKMLFEKVPQFLFESESRDGISMPRLIISQLKWLDRIVDSKDLT 196
Cdd:pfam14631   81 LPCVPLQSEEAsSMVTSYQESLIKLLLGIEILQPAIIKTLFEKLPEFMFESVNSDGLNMPRLIINQLKWLDRIVDGKDLT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  197 TQMMQLISVAPVNLQHDFITSLPEILGDSQHANVGKELSELLVQNTSLTVPILDVFSSLRLDPNFLSEIRQLVMGKLSSV 276
Cdd:pfam14631  161 SKLMQLISVAPVELQHDIITSLPEILEDSQHNDVARELSSLLVENTQLTVPILDALSSLNLDPTLLSEVRQAVMGTLSAV 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  277 RLEDLPVIVKFILHSVTDSTSLEVIAELREKLNVQHFTLPSRIQASQSKLKSKGLASSSGNQENSDKDCIVLLFDVIKSA 356
Cdd:pfam14631  241 QLEDLPVVVKFILHSVSATDAYEVISELRKKLDLEQCVLPPVLQASQSKLKSKGAASSSGNQASSSQDCISLVFDVIKSA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  357 IRYEKTISEAWIKAIERIQSAAEHKALDVAMLLIIYGTSTQTKKGVERLLRNKIQSDCIQEQLLDSTFSTHCLVLKDICP 436
Cdd:pfam14631  321 VRFQKTISEAWLKAIENIDSVSDHKVLDLLMLFIIYSTNANQKKGIERVLRNKVRSGCIQEQLLQSTFRTHALVLRDYFP 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  437 SILLLAQTLFHSQDQRIILFGSLLCKYAFKFFDTYCQQEVVGALVTHVCSGNEAEVDAALDVLLELIVLNASAMRLNAAF 516
Cdd:pfam14631  401 SILALAQSLLHSPDQSIVSFGSHMYKYAFTAFDSYCQQEVVGALVTHVCSGNEAEVDVALELLLELVVLKPSAMRLYAVF 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  517 IKGILDYLENMSPQQIRKIFCILSTLAFSQQPGTSNHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAEDRTmPS 596
Cdd:pfam14631  481 VKGILDYMDNLTPQQIRKLFHILSTLAFSQQHEQSSHIQDDMHIVIRKQLSSTVPKYKRIGIIGAVTMVGSMAADRS-KS 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  597 NSTQRSASVSSEQHTQVTSLLQLVHSCTEHSPWASSLYYDEFANLIQERKLAPKTLEWVAQTIFNDFQDAFVVDFCAVPE 676
Cdd:pfam14631  560 GSSSQSASLSKEQCRQVTSLLELVHSCSEQSPQAAALYYDELANLIQKGKLDPKVLEWIGQSVLNDFQDDFVVDLGPDIE 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  677 GDFPFPVKALYGLEECNTQDGIVINLLPLFF-QEFAKDVSQVTSQESSQKSMSPLCLASHFRLLRLCVARQHNGNLDEID 755
Cdd:pfam14631  640 GDFPFPVKALYGLEEEESQGGIAINLLPLLAkDEQAKDEGEVTAQEKGQKRVSPLCLSPFFRLLRLCVEKQHDGDLEEID 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  756 ALLDCPLFLPDLEPGEKLESMSAKDRSLMCSLTFLTFNWFREVVNAFCQQTSPEMKGKVLSRLKDLVELQEILEKYLAVI 835
Cdd:pfam14631  720 GLLGCPLILTDLEVGEKLESLSKKEREFLCSLLFHTINWFREVVNAFCQQKDPEMKGKVLTRLQNITELQSLLEKYLAVT 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  836 PDYVPPFTSVDLDTLDviprsnsavaaksrhkgktggkkqkadsstasctdtllTEDTSECDVAPSGKSQVDKESTGKEG 915
Cdd:pfam14631  800 PGYVPPLANFDLDSSQ--------------------------------------KEEASEAEESQSEKSQLEKEFKGKEG 841

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  916 KTFVSLQNYRAFFRELDIEVFSILHSGLVTKFILDTEMHTEATEVVQLGPAELLFLLEDLSQKLENRLTPSFTKRVCFFK 995
Cdd:pfam14631  842 KTGVSLQSYRAFFRELDIEVFSVLHCGLLTKSLLDTEMHTKAREEVQLGPAELLFLLEDLSRKLEFMLTPAPAKRAPFLK 921

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  996 NKGSRNIGFSHLHQRSVQDIVHCVVQLLTPMCNHLENIHNFFQCLGAENLSVNDKARVTAQEHYTMSSCYQKLLQVFHAL 1075
Cdd:pfam14631  922 GKGDRNVGFSHLQQRSAQEIAHCVVQLLPPLCNHLENIHNYFQCLLAENHGVVDGPGVDVQEHQLMSSCYQLLLQVLHTL 1001

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1076 LAWKGFTHQSNHRLLRSALEVLASRLKQTEEGQPLEELLSQSFSYLQNLQHSIPSFQCGLYLLRLLMALLEKSAVPTQKK 1155
Cdd:pfam14631 1002 FAWSGFSQPENRSLLKSALGVLAGRLKEGEAELTLEELVSHSFEYLQNFRSSVPSFQCALCLIQLLIVIAEKSGNPAAKR 1081

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1156 EKLASLAKQLLCRAW--PHGDKEKNPTFNDHLHDLLCIYLEHTDNVLKAIEEITGVGVPELVNAPKDASSSTFPTLTRHT 1233
Cdd:pfam14631 1082 EKIASLARQFLCQVWvtPSGEKEKGNKFNDALHTLLCIYLEHTDDVLKAIEEIAGEGVPELINSSKDASSSTFPTLTRQT 1161

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1234 FVIFFRVMMAELEKTVKGLQAGTATDSQQVHEEKLLYWNMAVRDFSILINLMKVFDSYPVLHVCLKYGRRFVEAFLKQCM 1313
Cdd:pfam14631 1162 FLVFFRVMMAELEKSVRKIQPGTASDSQEVQEEKLLYWNMAVRDFHILVNLVKVFDSRPVLHVCLKYGRLFVEAFLKLGM 1241

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1314 PLLDFSFRKHRDDVLSLLQTLQLNTRLLHHLCGHSKIHQDTRLTKHVPLLKKSLELLVCRVKAMLVLNNCREAFWLGTLK 1393
Cdd:pfam14631 1242 PLLDFSFKKHREDVQSLLKTFQLSTRQLHHMCGHSKIHQDTGLTNHVPLLKKSLELFVYRVKAMLVLNNCQEAFWLGNLK 1321

                         1370      1380
                   ....*....|....*....|....*..
gi 1958769650 1394 NRDLQGEEIISQhpSSPENTSEDSEDG 1420
Cdd:pfam14631 1322 NRDLQGEEILSQ--RSQESDEEEEEDS 1346
FANCD2 cd11721
Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
 93-1405 0e+00

Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCD2 is required for DNA damage-induced intra-S phase checkpoint and for cellular resistance to DNA crosslinking agents.


Pssm-ID: 212595  Cd Length: 1161  Bit Score: 1366.61  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650   93 PKVIEEFVNGLESYTEDIDSLRNCLLSCERLQDEEASMGTFYSKSLIKLLLGIDILQPAIIKMLFEKVPQFLFESES-RD 171
Cdd:cd11721      1 PENVDEFLSGLEDFLADRDRLRKALLPCNLLTTESSSASSVPQDSLIRLLLQVDPLQPKVIELLLEKLPEFLDEDASvPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  172 GISMPRLIISQLKWLDRIVDSKDLTTQMMQLISVAPVNLQHDFITSLPEILGDSQHANVGKELSELLVQNTSLTVPILDV 251
Cdd:cd11721     81 EDNLPRLILNQFKWLDHIVDSEDLTEKLLELLSVAPSELQKEIITSLPEIIGDSQHEDVAEELCKLLQENSELTVPILDA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  252 FSSLRLDPNFLSEIRQLVMGKLSSVRLEDLPVIVKFILHSVTDSTSLEVIAELREKLNVQHFTLPSRIqasqsklkskgl 331
Cdd:cd11721    161 LSNLNLSPELLSEIREKVLSCLKTVPLEDLPVLVKFLLQSITATEALEIISKLRKNLDFSPLSDPSSS------------ 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  332 aSSSGNQENSDKDCIVLLFDVIKSAIRYEKTISEAWIKAIERIQSAAEHKALDVAMLLIIYGTSTQTKKGVERLLRNKIQ 411
Cdd:cd11721    229 -GSSDKSKASANSCQSLILEAIKSALRFSKLLAEAWIKVISSIDAPQDHKVIDLILLLILYSTNEDKRKSIESLLKKKIK 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  412 SDCIQEQLLDSTFSTHCLVLKDICPSILLLAQTLFHSQDQRIILFGSLLCKYAFKFFDTYCQQEVVGALVTHVCSGNEAE 491
Cdd:cd11721    308 SGFIRTSLLDLAFTGHSQVLKDYFKSLLSLADNLLRSAEPVVREFGSHLYKLLFKHFDRYYQQEVVGALITHIGSGNSSE 387

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  492 VDAALDVLLELIVLNASAMRLNAAFIKGILDYLENMSPQQIRKIFCILSTLAFSQQP-GTSNHIQDDMHLVIRKQLSSTV 570
Cdd:cd11721    388 VDAALDVLRELAEKNPDELLPYATFIKGILDYLDSLNLKQIRQLFDILCHLAFSERPlSEGSSIQDDLHIIVRKQLSNSS 467

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  571 FKYKLIGIIGAVTMAGIMAEDRTMPSN---STQRSASVSSEQHTQVTSLLQLVHSCTEHSPWASSLYYDEFANLI-QERK 646
Cdd:cd11721    468 PKYKRMGIIGAVTLVKHLASANSSDDAverSSSNGSSLPDERLKQAANLLELVLSSCKNSPEALALFYDELANIIsQASN 547

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  647 LAPKTLEWVAQTIFNDFQDAFVVDFCavpegdfpfpvkalygleecntqdgivinllplffqefakdvsqvtsqessqkS 726
Cdd:cd11721    548 LDPKFLEWLGETITEDFQESFVVDLD-----------------------------------------------------E 574

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  727 MSPLCLASHFRLLRLCVARQHNGNLDEIDALLDCPLFLPDLEPGEKLESMSAKDRSLMCSLTFLTFNWFREVVNAFCQQT 806
Cdd:cd11721    575 TSSAILASLFRLLRLLERSQQGGSLDEIDALLGCPLVLPDFEVDEKFDSLSTEQRSVVLDCLFYAINWFREVINAFATQK 654

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  807 SPEMKGKVLSRLKDLVELQEILEKYLAVipdyvppftsvdldtldviprsnsavaaksrhkgktggkkqkadsstasctd 886
Cdd:cd11721    655 DASTKKKVLKRLRNLIELEGRLSKLLAH---------------------------------------------------- 682

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  887 tlltedtsecdvapsgksqvdkestgkegktfvslqnyrAFFRELDIEVFSILHSGLVTKFILdtemHTEATEVVQLGPA 966
Cdd:cd11721    683 ---------------------------------------CYFRELDLEVFSLLKSGLVTDTSL----ELSEEEGVHLGPK 719

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  967 ELLFLLEDLSQKLENRLTPSFTKRVcFFKNKGSRNIGFSHLHQRSVQDIVHCVVQLLTPMCNHLENIHNFFQCLGAENLS 1046
Cdd:cd11721    720 ELRFLLEDLNRKLEHVLTSPKKKRM-PLLKPLKKGQGFSSLSQKSPKEVLKALVPLLPHLCKHLEKIHNYLQNLLLSNAG 798

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1047 VNDKARVTAQEHYTMSSCYQKLLQVFHALLAWKGFTHQSNHRLLRSALEVLASRLK-QTEEGQPLEELLSQSFSYLQNLQ 1125
Cdd:cd11721    799 QLDAPGPFVQENQYAKSCYGLLLQCLRLLFAWPGFSSQSNRVLLKSALRAIASRLKeSTGKDLPLKELVSSLFKYLKSFE 878

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1126 HSIPSFQCGLYLLRLLMALLEKSAVPTQKKEKLASLAKQLLCRAWPH--GDKEKNPTFNDHLHDLLCIYLEHTDNVLKAI 1203
Cdd:cd11721    879 PSVPSLSTAVSLVQLLQALMEKSPDRPQLREKLADLARNFLCRQWPDlsGESEKGQKYNDLIDTLLRIYLEHSDDPLKKL 958

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1204 EEITGVGVPELVNAPKD-ASSSTFPTLTRHTFVIFFRVMMAELEKTVKGLQAGTAtDSQQVHEEKLLYWNMAVRDFSILI 1282
Cdd:cd11721    959 EEIAGEALPELLEKKKDkDALETFPTLSKSTFPIFFRVLMEALIESVKKILSSAA-DTGGGEMERLLLWQSAVRVFKALV 1037

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1283 NLMKVFDSYPVLHVCLKYGRRFVEAFLKQCMPLLDFSFRKHRDDVLSLLQTLQLNTRLLHHLCGHSKIHQDTRLTKHVPL 1362
Cdd:cd11721   1038 NLVKTFDKRPVLAICLKYGRLFLKLFLKLGMPLLEKLFKNHKEEVQELLKTLQQSTRYLHHICCHSKIHKDTALTNHVPA 1117

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|...
gi 1958769650 1363 LKKSLELLVCRVKAMLVLNNCREAFWLGTLKNRDLQGEEIISQ 1405
Cdd:cd11721   1118 LKKSLETLVYRVKAMLVANNCSEAFWMGNLKNKDLQGEEILSQ 1160
 
Name Accession Description Interval E-value
FancD2 pfam14631
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
 38-1420 0e+00

Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.


Pssm-ID: 464225  Cd Length: 1346  Bit Score: 2343.24  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650   38 SCGSHEVEENGSVFVRLLKASGLTLKTGDNQNQLGVDQIIFQRKLFQALRKHPSYPKVIEEFVNGLESYTEDIDSLRNCL 117
Cdd:pfam14631    1 SHAQNEVEENGSVFVKLLKTAGVILKTGENQNEIAVDQVIFQKKLQQALRKHPSYPKVIEEFITGLESYIEDRDTFRNCL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  118 LSCERLQDEEA-SMGTFYSKSLIKLLLGIDILQPAIIKMLFEKVPQFLFESESRDGISMPRLIISQLKWLDRIVDSKDLT 196
Cdd:pfam14631   81 LPCVPLQSEEAsSMVTSYQESLIKLLLGIEILQPAIIKTLFEKLPEFMFESVNSDGLNMPRLIINQLKWLDRIVDGKDLT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  197 TQMMQLISVAPVNLQHDFITSLPEILGDSQHANVGKELSELLVQNTSLTVPILDVFSSLRLDPNFLSEIRQLVMGKLSSV 276
Cdd:pfam14631  161 SKLMQLISVAPVELQHDIITSLPEILEDSQHNDVARELSSLLVENTQLTVPILDALSSLNLDPTLLSEVRQAVMGTLSAV 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  277 RLEDLPVIVKFILHSVTDSTSLEVIAELREKLNVQHFTLPSRIQASQSKLKSKGLASSSGNQENSDKDCIVLLFDVIKSA 356
Cdd:pfam14631  241 QLEDLPVVVKFILHSVSATDAYEVISELRKKLDLEQCVLPPVLQASQSKLKSKGAASSSGNQASSSQDCISLVFDVIKSA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  357 IRYEKTISEAWIKAIERIQSAAEHKALDVAMLLIIYGTSTQTKKGVERLLRNKIQSDCIQEQLLDSTFSTHCLVLKDICP 436
Cdd:pfam14631  321 VRFQKTISEAWLKAIENIDSVSDHKVLDLLMLFIIYSTNANQKKGIERVLRNKVRSGCIQEQLLQSTFRTHALVLRDYFP 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  437 SILLLAQTLFHSQDQRIILFGSLLCKYAFKFFDTYCQQEVVGALVTHVCSGNEAEVDAALDVLLELIVLNASAMRLNAAF 516
Cdd:pfam14631  401 SILALAQSLLHSPDQSIVSFGSHMYKYAFTAFDSYCQQEVVGALVTHVCSGNEAEVDVALELLLELVVLKPSAMRLYAVF 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  517 IKGILDYLENMSPQQIRKIFCILSTLAFSQQPGTSNHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAEDRTmPS 596
Cdd:pfam14631  481 VKGILDYMDNLTPQQIRKLFHILSTLAFSQQHEQSSHIQDDMHIVIRKQLSSTVPKYKRIGIIGAVTMVGSMAADRS-KS 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  597 NSTQRSASVSSEQHTQVTSLLQLVHSCTEHSPWASSLYYDEFANLIQERKLAPKTLEWVAQTIFNDFQDAFVVDFCAVPE 676
Cdd:pfam14631  560 GSSSQSASLSKEQCRQVTSLLELVHSCSEQSPQAAALYYDELANLIQKGKLDPKVLEWIGQSVLNDFQDDFVVDLGPDIE 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  677 GDFPFPVKALYGLEECNTQDGIVINLLPLFF-QEFAKDVSQVTSQESSQKSMSPLCLASHFRLLRLCVARQHNGNLDEID 755
Cdd:pfam14631  640 GDFPFPVKALYGLEEEESQGGIAINLLPLLAkDEQAKDEGEVTAQEKGQKRVSPLCLSPFFRLLRLCVEKQHDGDLEEID 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  756 ALLDCPLFLPDLEPGEKLESMSAKDRSLMCSLTFLTFNWFREVVNAFCQQTSPEMKGKVLSRLKDLVELQEILEKYLAVI 835
Cdd:pfam14631  720 GLLGCPLILTDLEVGEKLESLSKKEREFLCSLLFHTINWFREVVNAFCQQKDPEMKGKVLTRLQNITELQSLLEKYLAVT 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  836 PDYVPPFTSVDLDTLDviprsnsavaaksrhkgktggkkqkadsstasctdtllTEDTSECDVAPSGKSQVDKESTGKEG 915
Cdd:pfam14631  800 PGYVPPLANFDLDSSQ--------------------------------------KEEASEAEESQSEKSQLEKEFKGKEG 841

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  916 KTFVSLQNYRAFFRELDIEVFSILHSGLVTKFILDTEMHTEATEVVQLGPAELLFLLEDLSQKLENRLTPSFTKRVCFFK 995
Cdd:pfam14631  842 KTGVSLQSYRAFFRELDIEVFSVLHCGLLTKSLLDTEMHTKAREEVQLGPAELLFLLEDLSRKLEFMLTPAPAKRAPFLK 921

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  996 NKGSRNIGFSHLHQRSVQDIVHCVVQLLTPMCNHLENIHNFFQCLGAENLSVNDKARVTAQEHYTMSSCYQKLLQVFHAL 1075
Cdd:pfam14631  922 GKGDRNVGFSHLQQRSAQEIAHCVVQLLPPLCNHLENIHNYFQCLLAENHGVVDGPGVDVQEHQLMSSCYQLLLQVLHTL 1001

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1076 LAWKGFTHQSNHRLLRSALEVLASRLKQTEEGQPLEELLSQSFSYLQNLQHSIPSFQCGLYLLRLLMALLEKSAVPTQKK 1155
Cdd:pfam14631 1002 FAWSGFSQPENRSLLKSALGVLAGRLKEGEAELTLEELVSHSFEYLQNFRSSVPSFQCALCLIQLLIVIAEKSGNPAAKR 1081

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1156 EKLASLAKQLLCRAW--PHGDKEKNPTFNDHLHDLLCIYLEHTDNVLKAIEEITGVGVPELVNAPKDASSSTFPTLTRHT 1233
Cdd:pfam14631 1082 EKIASLARQFLCQVWvtPSGEKEKGNKFNDALHTLLCIYLEHTDDVLKAIEEIAGEGVPELINSSKDASSSTFPTLTRQT 1161

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1234 FVIFFRVMMAELEKTVKGLQAGTATDSQQVHEEKLLYWNMAVRDFSILINLMKVFDSYPVLHVCLKYGRRFVEAFLKQCM 1313
Cdd:pfam14631 1162 FLVFFRVMMAELEKSVRKIQPGTASDSQEVQEEKLLYWNMAVRDFHILVNLVKVFDSRPVLHVCLKYGRLFVEAFLKLGM 1241

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1314 PLLDFSFRKHRDDVLSLLQTLQLNTRLLHHLCGHSKIHQDTRLTKHVPLLKKSLELLVCRVKAMLVLNNCREAFWLGTLK 1393
Cdd:pfam14631 1242 PLLDFSFKKHREDVQSLLKTFQLSTRQLHHMCGHSKIHQDTGLTNHVPLLKKSLELFVYRVKAMLVLNNCQEAFWLGNLK 1321

                         1370      1380
                   ....*....|....*....|....*..
gi 1958769650 1394 NRDLQGEEIISQhpSSPENTSEDSEDG 1420
Cdd:pfam14631 1322 NRDLQGEEILSQ--RSQESDEEEEEDS 1346
FANCD2 cd11721
Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
 93-1405 0e+00

Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCD2 is required for DNA damage-induced intra-S phase checkpoint and for cellular resistance to DNA crosslinking agents.


Pssm-ID: 212595  Cd Length: 1161  Bit Score: 1366.61  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650   93 PKVIEEFVNGLESYTEDIDSLRNCLLSCERLQDEEASMGTFYSKSLIKLLLGIDILQPAIIKMLFEKVPQFLFESES-RD 171
Cdd:cd11721      1 PENVDEFLSGLEDFLADRDRLRKALLPCNLLTTESSSASSVPQDSLIRLLLQVDPLQPKVIELLLEKLPEFLDEDASvPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  172 GISMPRLIISQLKWLDRIVDSKDLTTQMMQLISVAPVNLQHDFITSLPEILGDSQHANVGKELSELLVQNTSLTVPILDV 251
Cdd:cd11721     81 EDNLPRLILNQFKWLDHIVDSEDLTEKLLELLSVAPSELQKEIITSLPEIIGDSQHEDVAEELCKLLQENSELTVPILDA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  252 FSSLRLDPNFLSEIRQLVMGKLSSVRLEDLPVIVKFILHSVTDSTSLEVIAELREKLNVQHFTLPSRIqasqsklkskgl 331
Cdd:cd11721    161 LSNLNLSPELLSEIREKVLSCLKTVPLEDLPVLVKFLLQSITATEALEIISKLRKNLDFSPLSDPSSS------------ 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  332 aSSSGNQENSDKDCIVLLFDVIKSAIRYEKTISEAWIKAIERIQSAAEHKALDVAMLLIIYGTSTQTKKGVERLLRNKIQ 411
Cdd:cd11721    229 -GSSDKSKASANSCQSLILEAIKSALRFSKLLAEAWIKVISSIDAPQDHKVIDLILLLILYSTNEDKRKSIESLLKKKIK 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  412 SDCIQEQLLDSTFSTHCLVLKDICPSILLLAQTLFHSQDQRIILFGSLLCKYAFKFFDTYCQQEVVGALVTHVCSGNEAE 491
Cdd:cd11721    308 SGFIRTSLLDLAFTGHSQVLKDYFKSLLSLADNLLRSAEPVVREFGSHLYKLLFKHFDRYYQQEVVGALITHIGSGNSSE 387

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  492 VDAALDVLLELIVLNASAMRLNAAFIKGILDYLENMSPQQIRKIFCILSTLAFSQQP-GTSNHIQDDMHLVIRKQLSSTV 570
Cdd:cd11721    388 VDAALDVLRELAEKNPDELLPYATFIKGILDYLDSLNLKQIRQLFDILCHLAFSERPlSEGSSIQDDLHIIVRKQLSNSS 467

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  571 FKYKLIGIIGAVTMAGIMAEDRTMPSN---STQRSASVSSEQHTQVTSLLQLVHSCTEHSPWASSLYYDEFANLI-QERK 646
Cdd:cd11721    468 PKYKRMGIIGAVTLVKHLASANSSDDAverSSSNGSSLPDERLKQAANLLELVLSSCKNSPEALALFYDELANIIsQASN 547

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  647 LAPKTLEWVAQTIFNDFQDAFVVDFCavpegdfpfpvkalygleecntqdgivinllplffqefakdvsqvtsqessqkS 726
Cdd:cd11721    548 LDPKFLEWLGETITEDFQESFVVDLD-----------------------------------------------------E 574

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  727 MSPLCLASHFRLLRLCVARQHNGNLDEIDALLDCPLFLPDLEPGEKLESMSAKDRSLMCSLTFLTFNWFREVVNAFCQQT 806
Cdd:cd11721    575 TSSAILASLFRLLRLLERSQQGGSLDEIDALLGCPLVLPDFEVDEKFDSLSTEQRSVVLDCLFYAINWFREVINAFATQK 654

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  807 SPEMKGKVLSRLKDLVELQEILEKYLAVipdyvppftsvdldtldviprsnsavaaksrhkgktggkkqkadsstasctd 886
Cdd:cd11721    655 DASTKKKVLKRLRNLIELEGRLSKLLAH---------------------------------------------------- 682

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  887 tlltedtsecdvapsgksqvdkestgkegktfvslqnyrAFFRELDIEVFSILHSGLVTKFILdtemHTEATEVVQLGPA 966
Cdd:cd11721    683 ---------------------------------------CYFRELDLEVFSLLKSGLVTDTSL----ELSEEEGVHLGPK 719

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  967 ELLFLLEDLSQKLENRLTPSFTKRVcFFKNKGSRNIGFSHLHQRSVQDIVHCVVQLLTPMCNHLENIHNFFQCLGAENLS 1046
Cdd:cd11721    720 ELRFLLEDLNRKLEHVLTSPKKKRM-PLLKPLKKGQGFSSLSQKSPKEVLKALVPLLPHLCKHLEKIHNYLQNLLLSNAG 798

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1047 VNDKARVTAQEHYTMSSCYQKLLQVFHALLAWKGFTHQSNHRLLRSALEVLASRLK-QTEEGQPLEELLSQSFSYLQNLQ 1125
Cdd:cd11721    799 QLDAPGPFVQENQYAKSCYGLLLQCLRLLFAWPGFSSQSNRVLLKSALRAIASRLKeSTGKDLPLKELVSSLFKYLKSFE 878

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1126 HSIPSFQCGLYLLRLLMALLEKSAVPTQKKEKLASLAKQLLCRAWPH--GDKEKNPTFNDHLHDLLCIYLEHTDNVLKAI 1203
Cdd:cd11721    879 PSVPSLSTAVSLVQLLQALMEKSPDRPQLREKLADLARNFLCRQWPDlsGESEKGQKYNDLIDTLLRIYLEHSDDPLKKL 958

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1204 EEITGVGVPELVNAPKD-ASSSTFPTLTRHTFVIFFRVMMAELEKTVKGLQAGTAtDSQQVHEEKLLYWNMAVRDFSILI 1282
Cdd:cd11721    959 EEIAGEALPELLEKKKDkDALETFPTLSKSTFPIFFRVLMEALIESVKKILSSAA-DTGGGEMERLLLWQSAVRVFKALV 1037

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1283 NLMKVFDSYPVLHVCLKYGRRFVEAFLKQCMPLLDFSFRKHRDDVLSLLQTLQLNTRLLHHLCGHSKIHQDTRLTKHVPL 1362
Cdd:cd11721   1038 NLVKTFDKRPVLAICLKYGRLFLKLFLKLGMPLLEKLFKNHKEEVQELLKTLQQSTRYLHHICCHSKIHKDTALTNHVPA 1117

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|...
gi 1958769650 1363 LKKSLELLVCRVKAMLVLNNCREAFWLGTLKNRDLQGEEIISQ 1405
Cdd:cd11721   1118 LKKSLETLVYRVKAMLVANNCSEAFWMGNLKNKDLQGEEILSQ 1160
FANC cd11719
Fanconi anemia ID complex proteins FANCI and FANCD2; The Fanconi anemia ID complex consists of ...
 133-1283 0e+00

Fanconi anemia ID complex proteins FANCI and FANCD2; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome.


Pssm-ID: 212593  Cd Length: 977  Bit Score: 1249.82  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  133 FYSKSLIKLLLGID----ILQPAIIKMLFEKVPQFLFESESR-DGISMPRLIISQLKWLDRIVDSKDLTTQMMQLISVAP 207
Cdd:cd11719      1 RAVGTLLRAVLKGSpcseEDGALRRYKIYSCCIQLVESGDLQqDVASEIIGLLMLEVHHFPGPLLVDLASDFVGAVREDR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  208 VNLQHDFITSLPEILG-----------------DSQHANVGKELSELLvQNTSLTVPILDVFSSLRLDPNFLSEIRQLVM 270
Cdd:cd11719     81 LVNGKSLELLPIILTAlatkkevlacgkgdlngEEYKRQLIDTLCSVR-WPQRYMIQLTSVFKDVCLTPEEMNLVVAKVL 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  271 GKLSSVRLEDLPVIVKFILHS---VTDSTSLEVIAELREKLNVQHFTLPSRIQAsqsklkskglASSSGNQENSDKDCIV 347
Cdd:cd11719    160 TMFSKLNLQEIPPLVYQLLVLsskGSRRSVLDGIIAFFRELDKQHREEQSSDEL----------SELITAPADELYHVEG 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  348 LLFDVIKSAIRYE-KTISEAWIKAIERIQSA--AEHKALDVAMLLIIYGTSTQTKKGVERLLRNKIQSDC---------- 414
Cdd:cd11719    230 TVILHIVFAIKLDcELGRELLKHLKAGQQGDpsKCLCPFSIALLLSLTRIQRFEEQVFDLLKTSVVKSFKdlqllqgskf 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  415 ---------IQEQLLDSTFSTHCLVLKDICPSILLLAQTLFHS---------------------QDQRIILFGSLLCKYA 464
Cdd:cd11719    310 lqtlvpqrtCVSTMILEVVRNSVHSWDHVTQGLIEFGFILMDSygpkkildgkaveigtslskmTNQHACKLGANILLET 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  465 FKfFDTYCQQEVVGALVTHVCSGNEAEVDAALDVLLELIVLNASAmRLNAAFIKGILDYLENMSPQQIRKIFCILSTLAF 544
Cdd:cd11719    390 FK-IHEMIRQEILEQVLNRVVTRTSSPINHFLDLFSDIIMYAPLI-LQNCSKVTETFDYLTFLPLQTVQGLLKAVQPLLK 467

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  545 SQqpgtsNHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAEDRTMPSNS------------TQRSASVSSEQHTQ 612
Cdd:cd11719    468 IS-----MSMRDSLILVLRKAMFASQLDARKSAVAGFLLLLKNFKVLGSLPSSQctqsigvtqvrvDVHSRYSAVANETF 542

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  613 VTSLLQLVHSCTEHSPWASSLYYDefanliqERKLAPKTLEWVAQTIFNDFQDAFVVDFCAVPEGDFPFPVKAlygleec 692
Cdd:cd11719    543 CLEIIDSLKRSLGQQADIRLMLYD-------GFYDVLRRNSQLASSIMQTLFSQLKQFYEPEPDLLPPLKLGA------- 608

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  693 ntqdgivinllplffqefakdvsqvTSQESSQKSMSPLCLASHFRLLRLCVARQhngnldeidalldcplflpdlepgek 772
Cdd:cd11719    609 -------------------------CVLTQGSQIFLQEPLDHLLSCIQHCLAWY-------------------------- 637

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  773 lesmsakdrslmcsltflTFNWFREVVNAFCQQTSPE-----MKGKVLSRLKDLVELQEIlekylavipdyvppftsvdl 847
Cdd:cd11719    638 ------------------ACLIMGVCEVLMEYNFSISnfsksKFEEILSLFTCYKKFSDI-------------------- 679

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  848 dtldviprsnsavaaksrhkgktggkkqkadsstasctdtlltedtsecdvapsgksqvdkestgkegktfvslqnyraf 927
Cdd:cd11719        --------------------------------------------------------------------------------

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650  928 frelDIEVFSILHSGLVTKFILDT---EMHTEATEVVQLGPAELLFLLEDLSQKLENrltpsftkrvcffknkgsrnigf 1004
Cdd:cd11719    680 ----IFQNLCDITRVLLWRYTSIPtsvEESGKKEKGKSISLLCLEGLQKTFSVVLQF----------------------- 732

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1005 shlhqrsvqdIVHCVVQLL-----------------TPMCNHLENIHNFFQCLGAEnlsvndkARVTAQEHYTMSSCYQK 1067
Cdd:cd11719    733 ----------YQPKVQQFLqaldvmgteeeeagvtvTQRASFQIRQFQRSLLNLLS-------SEEDDFNSKEALLLIAV 795

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1068 LLQVFHALLAwkgfthqsnhrllrsalevlasrlkqteegqpleelLSQSFSYLQNLQH----------SIPSFQCGLYL 1137
Cdd:cd11719    796 LSTLSRLLEP------------------------------------TSPQFVQMLSWTSkickeysqedASFCKSLMNLF 839

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1138 LRLLMALLEksavptqkkeklASLAKQLLCRAWPHGDK-----------------EKNPTFNDHLHDLLCIYLEhtDNVL 1200
Cdd:cd11719    840 FSLHVLYKS------------PVTLLRDLSQDIHGQLGdidqdveiektdhfavvNLRTAAPTVCLLVLSQAEK--VMQL 905

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769650 1201 KAIEEITGVGVPElvnapkdassSTFPTLTRHTFVIFFRVMMAELEKTVKGLQAGTAtDSQQVHEEKLLYWNMAVRDFSI 1280
Cdd:cd11719    906 GTLVTFFHELVQT----------ALPSGSCVDTLLKGLSKIYSTLTAFVKYYLQVCQ-SSRGIPNTVEKLVKLSGSHLTP 974


                   ...
gi 1958769650 1281 LIN 1283
Cdd:cd11719    975 VCY 977
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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