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Conserved domains on  [gi|1958775674|ref|XP_038965575|]
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eukaryotic translation initiation factor 4 gamma 3 isoform X7 [Rattus norvegicus]

Protein Classification

MIF4G domain-containing protein( domain architecture ID 10501428)

MIF4G (middle domain of eukaryotic initiation factor 4G) domain-containing protein may contain multiple alpha-helical repeats; similar to Saccharomyces cerevisiae suppressor of glycerol defect protein 1 and Arabidopsis thaliana eukaryotic translation initiation factor isoform 4G

CATH:  1.25.40.180
Gene Ontology:  GO:0003723|GO:0005515
SCOP:  4000569

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 958-1186 7.80e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


:

Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.08  E-value: 7.80e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  958 FRKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLkvpmadkpgNTVNFR 1037
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674 1038 KLLLNRCQKEFEKdkadddvfekkqkeleaasapeertrlHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCV 1117
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958775674 1118 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLCN 1186
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1424-1536 8.39e-36

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


:

Pssm-ID: 397128  Cd Length: 113  Bit Score: 132.01  E-value: 8.39e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674 1424 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1503
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1958775674 1504 TLELADDMAIDIPHIWLYLAELVTPMLKEGGIS 1536
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 65-487 5.07e-10

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.96  E-value: 5.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674   65 RALQTPAPQQIPRGPVqqpledriFPPTVSavysTVTQVARQPGPPTPSPYSAHEINKGHPNLAATPPGHASSPGLSQTP 144
Cdd:PHA03247  2672 RAAQASSPPQRPRRRA--------ARPTVG----SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAP 2739

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  145 YPSGQNAGPATLVYPQAPQTMNSQPQARSPPSRAVPVHCPDNWKRRKVLEQTPVYRSLAGRGWIKYciggfrpiqffQRP 224
Cdd:PHA03247  2740 APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPA-----------DPP 2808

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  225 QIQPPRAAIPNSSPSLRPGAQTPTAVYQANQHImmvNHLPMPYPVPQG----PQYCIPQYRHSGPPYVGPPQQYPVQPPG 300
Cdd:PHA03247  2809 AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP---PPGPPPPSLPLGgsvaPGGDVRRRPPSRSPAAKPAAPARPPVRR 2885

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  301 PGPFYPGPGPGDFANAYGTPFYPSQPVYQSAPIIVPTQQQPP-PAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPP 379
Cdd:PHA03247  2886 LARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPqPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG 2965

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  380 IGRPTSTPTPPQQLPSQAPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVfqspsTVLRLVLSGEKKEQAGQI 459
Cdd:PHA03247  2966 ALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPV-----SLKQTLWPPDDTEDSDAD 3040

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 1958775674  460 P-------ETAAGEPSPEPPRTSSPTTLPPLARSS 487
Cdd:PHA03247  3041 SlfdsdseRSDLEALDPLPPEPHDPFAHEPDPATP 3075
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 958-1186 7.80e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.08  E-value: 7.80e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  958 FRKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLkvpmadkpgNTVNFR 1037
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674 1038 KLLLNRCQKEFEKdkadddvfekkqkeleaasapeertrlHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCV 1117
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958775674 1118 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLCN 1186
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 959-1183 4.12e-51

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 179.48  E-value: 4.12e-51
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674   959 RKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVtLKVPmadkpgntvNFRK 1038
Cdd:smart00543    2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLN-AKNP---------DFGS 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  1039 LLLNRCQKEFEKDkadddvfekkqkeleaasapeertrlhdeLEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVV 1118
Cdd:smart00543   72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958775674  1119 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKT---SSRIRFMLQDVIDLR 1183
Cdd:smart00543  123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELR 197
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1424-1536 8.39e-36

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 132.01  E-value: 8.39e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674 1424 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1503
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1958775674 1504 TLELADDMAIDIPHIWLYLAELVTPMLKEGGIS 1536
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 1424-1536 1.66e-33

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 125.43  E-value: 1.66e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  1424 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1503
Cdd:smart00544    1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80

                            90       100       110
                    ....*....|....*....|....*....|...
gi 1958775674  1504 TLELADDMAIDIPHIWLYLAELVTPMLKEGGIS 1536
Cdd:smart00544   81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
PHA03247 PHA03247
large tegument protein UL36; Provisional
 65-487 5.07e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.96  E-value: 5.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674   65 RALQTPAPQQIPRGPVqqpledriFPPTVSavysTVTQVARQPGPPTPSPYSAHEINKGHPNLAATPPGHASSPGLSQTP 144
Cdd:PHA03247  2672 RAAQASSPPQRPRRRA--------ARPTVG----SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAP 2739

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  145 YPSGQNAGPATLVYPQAPQTMNSQPQARSPPSRAVPVHCPDNWKRRKVLEQTPVYRSLAGRGWIKYciggfrpiqffQRP 224
Cdd:PHA03247  2740 APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPA-----------DPP 2808

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  225 QIQPPRAAIPNSSPSLRPGAQTPTAVYQANQHImmvNHLPMPYPVPQG----PQYCIPQYRHSGPPYVGPPQQYPVQPPG 300
Cdd:PHA03247  2809 AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP---PPGPPPPSLPLGgsvaPGGDVRRRPPSRSPAAKPAAPARPPVRR 2885

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  301 PGPFYPGPGPGDFANAYGTPFYPSQPVYQSAPIIVPTQQQPP-PAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPP 379
Cdd:PHA03247  2886 LARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPqPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG 2965

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  380 IGRPTSTPTPPQQLPSQAPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVfqspsTVLRLVLSGEKKEQAGQI 459
Cdd:PHA03247  2966 ALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPV-----SLKQTLWPPDDTEDSDAD 3040

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 1958775674  460 P-------ETAAGEPSPEPPRTSSPTTLPPLARSS 487
Cdd:PHA03247  3041 SlfdsdseRSDLEALDPLPPEPHDPFAHEPDPATP 3075
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 73-286 4.27e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 48.49  E-value: 4.27e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674   73 QQIPRGPVQQPledRIFPPTVSAVYSTVTQVARQPGPPTPSPYSAHEINKGHPNLAA------TPPGHASSPglSQTPYP 146
Cdd:pfam09770  105 QQPAARAAQSS---AQPPASSLPQYQYASQQSQQPSKPVRTGYEKYKEPEPIPDLQVdaslwgVAPKKAAAP--APAPQP 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  147 SGQNAGP--------------------ATLVYPQAPQTMNSQPQARSPPSRAVPVHCPDNWKRRKVLEQTPVYRSLAGrg 206
Cdd:pfam09770  180 AAQPASLpapsrkmmsleeveaamraqAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHP-- 257

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  207 wikyciGGFRPIQFFQRPQIQPPRAAIPNSSPSLRPGAQTPTAVYQANQHIM------MVNHLPMPYPVPQGPQYCIPQY 280
Cdd:pfam09770  258 ------GQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILqnpnrlSAARVGYPQNPQPGVQPAPAHQ 331


                   ....*.
gi 1958775674  281 RHSGPP 286
Cdd:pfam09770  332 AHRQQG 337
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 958-1186 7.80e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.08  E-value: 7.80e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  958 FRKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLkvpmadkpgNTVNFR 1037
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674 1038 KLLLNRCQKEFEKdkadddvfekkqkeleaasapeertrlHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCV 1117
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958775674 1118 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLCN 1186
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 959-1183 4.12e-51

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 179.48  E-value: 4.12e-51
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674   959 RKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVtLKVPmadkpgntvNFRK 1038
Cdd:smart00543    2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLN-AKNP---------DFGS 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  1039 LLLNRCQKEFEKDkadddvfekkqkeleaasapeertrlhdeLEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVV 1118
Cdd:smart00543   72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958775674  1119 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKT---SSRIRFMLQDVIDLR 1183
Cdd:smart00543  123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELR 197
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1424-1536 8.39e-36

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 132.01  E-value: 8.39e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674 1424 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1503
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1958775674 1504 TLELADDMAIDIPHIWLYLAELVTPMLKEGGIS 1536
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 1424-1536 1.66e-33

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 125.43  E-value: 1.66e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  1424 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1503
Cdd:smart00544    1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80

                            90       100       110
                    ....*....|....*....|....*....|...
gi 1958775674  1504 TLELADDMAIDIPHIWLYLAELVTPMLKEGGIS 1536
Cdd:smart00544   81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
PHA03247 PHA03247
large tegument protein UL36; Provisional
 65-487 5.07e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.96  E-value: 5.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674   65 RALQTPAPQQIPRGPVqqpledriFPPTVSavysTVTQVARQPGPPTPSPYSAHEINKGHPNLAATPPGHASSPGLSQTP 144
Cdd:PHA03247  2672 RAAQASSPPQRPRRRA--------ARPTVG----SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAP 2739

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  145 YPSGQNAGPATLVYPQAPQTMNSQPQARSPPSRAVPVHCPDNWKRRKVLEQTPVYRSLAGRGWIKYciggfrpiqffQRP 224
Cdd:PHA03247  2740 APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPA-----------DPP 2808

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  225 QIQPPRAAIPNSSPSLRPGAQTPTAVYQANQHImmvNHLPMPYPVPQG----PQYCIPQYRHSGPPYVGPPQQYPVQPPG 300
Cdd:PHA03247  2809 AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP---PPGPPPPSLPLGgsvaPGGDVRRRPPSRSPAAKPAAPARPPVRR 2885

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  301 PGPFYPGPGPGDFANAYGTPFYPSQPVYQSAPIIVPTQQQPP-PAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPP 379
Cdd:PHA03247  2886 LARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPqPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG 2965

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  380 IGRPTSTPTPPQQLPSQAPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVfqspsTVLRLVLSGEKKEQAGQI 459
Cdd:PHA03247  2966 ALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPV-----SLKQTLWPPDDTEDSDAD 3040

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 1958775674  460 P-------ETAAGEPSPEPPRTSSPTTLPPLARSS 487
Cdd:PHA03247  3041 SlfdsdseRSDLEALDPLPPEPHDPFAHEPDPATP 3075
PHA03247 PHA03247
large tegument protein UL36; Provisional
 65-536 6.58e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.57  E-value: 6.58e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674   65 RALQTPAPQQIPRGPVQQPLEDRIFPPTVSAvySTVTQVA-----RQPGPPTPSPYSAHeinkghpnlAATPPGHASSPG 139
Cdd:PHA03247  2566 RSVPPPRPAPRPSEPAVTSRARRPDAPPQSA--RPRAPVDdrgdpRGPAPPSPLPPDTH---------APDPPPPSPSPA 2634

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  140 LSQTPYPSGQNAGPATLVYPQ-APQTMNSQPQARSPPSRAVPVHCPDNWKRRKVleqtpvyRSLAGrgwikyciggfrPI 218
Cdd:PHA03247  2635 ANEPDPHPPPTVPPPERPRDDpAPGRVSRPRRARRLGRAAQASSPPQRPRRRAA-------RPTVG------------SL 2695

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  219 QFFQRPqiqPPRAAIPNSSP-SLRPGAQTPTAVYQANQHIMMVNHLPMPYPVPQGPQYCIPQYRHSGPPYVGPPQQYPVQ 297
Cdd:PHA03247  2696 TSLADP---PPPPPTPEPAPhALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP 2772

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  298 PpgpgpfypgpgpgdfANAYGTPfyPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQggkdiTEEIMSGGGSRNPT 377
Cdd:PHA03247  2773 A---------------APAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAA-----ALPPAASPAGPLPP 2830

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  378 PPIGRPTSTPTPPQQL-PSQAPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKKEQA 456
Cdd:PHA03247  2831 PTSAQPTAPPPPPGPPpPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQ 2910

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  457 GQIPE------TAAGEPSPEPPRTSSPTTLPPLARSSLPSPMSAA--LSSQQLLTAEDKCELSSSKDDAPPVRSPTSCTA 528
Cdd:PHA03247  2911 PQAPPppqpqpQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPsgAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPA 2990


                   ....*...
gi 1958775674  529 APGPSLTD 536
Cdd:PHA03247  2991 SSTPPLTG 2998
PHA03247 PHA03247
large tegument protein UL36; Provisional
 132-558 2.12e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.49  E-value: 2.12e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  132 PGHAS--SPGLSQTPYPSGQNAGPATLVYPQapqtmnsqPQARSPPSRAVPVHCPDnwkrRKVLEQTPVyRSLAgrgWIk 209
Cdd:PHA03247  2475 PGAPVyrRPAEARFPFAAGAAPDPGGGGPPD--------PDAPPAPSRLAPAILPD----EPVGEPVHP-RMLT---WI- 2537

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  210 yciggfRPIQFFQRPQIQPPRAAIPNSSPSLRPGAQTPTavyqanqhimmvnhlPMPYPVPQGPQYCIPQYRHSGPPYVG 289
Cdd:PHA03247  2538 ------RGLEELASDDAGDPPPPLPPAAPPAAPDRSVPP---------------PRPAPRPSEPAVTSRARRPDAPPQSA 2596

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  290 PPQQYPVQPPGPGPFYPGPGPGDFANAYGTPFYPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEIMS 369
Cdd:PHA03247  2597 RPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQA 2676

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  370 GGGSRNPTPPIGRPTSTPT-----PPQQLPSQAPEHSPVVYGT----VESAHLAASTPVTAAsdqkqeekPKPDPVFQSP 440
Cdd:PHA03247  2677 SSPPQRPRRRAARPTVGSLtsladPPPPPPTPEPAPHALVSATplppGPAAARQASPALPAA--------PAPPAVPAGP 2748

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  441 STVLRLVLSGEKKEQAGQIPETAAGEPSPEPPRTSSPTTLPPLA--RSSLPSPMSAALSSQQLLTAedKCELSSSKDDAP 518
Cdd:PHA03247  2749 ATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSesRESLPSPWDPADPPAAVLAP--AAALPPAASPAG 2826

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 1958775674  519 PVRSPTSCTAAPGPSLTDDIGLCKKPCGVAPPDGQLVSSP 558
Cdd:PHA03247  2827 PLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRP 2866
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 90-507 4.22e-06

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 52.01  E-value: 4.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674   90 PPTVSAVYSTVTQVARQPGPP-TPS-PYSAHEINKGHPNLAATPpghasSPGLsQTPYPSgqnAGPATLVYPQAPQTMNS 167
Cdd:PRK10263   319 PVAVAAAATTATQSWAAPVEPvTQTpPVASVDVPPAQPTVAWQP-----VPGP-QTGEPV---IAPAPEGYPQQSQYAQP 389

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  168 QPQARSPPSRAVPVHCPDNWKRRKVLEQTPVYRSLAGRGwikyciggfrPIQFFQRPQIQPPRAAIPNSSPSLRPGAQtP 247
Cdd:PRK10263   390 AVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQP----------AQQPYYAPAPEQPVAGNAWQAEEQQSTFA-P 458

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  248 TAVYQANQhimmvnhlPMPYPVPQGPQYCIPQYrhsgppyvgppqqypvqppgpgpfypgpgpgdfanaygtpfYPSQPV 327
Cdd:PRK10263   459 QSTYQTEQ--------TYQQPAAQEPLYQQPQP-----------------------------------------VEQQPV 489

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  328 YQSAPIIVPTQQQPPP----AKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPPIGRPTSTPtPPQQLPSQAPehspv 403
Cdd:PRK10263   490 VEPEPVVEETKPARPPlyyfEEVEEKRAREREQLAAWYQPIPEPVKEPEPIKSSLKAPSVAAVP-PVEAAAAVSP----- 563

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  404 VYGTVESAHLAASTPVTAASdqkqeekpkpdPVFQspstvlrLVLSGEKKEQAGQipetAAGEPSPEPPRTSSPTtlppl 483
Cdd:PRK10263   564 LASGVKKATLATGAAATVAA-----------PVFS-------LANSGGPRPQVKE----GIGPQLPRPKRIRVPT----- 616

                          410       420
                   ....*....|....*....|....
gi 1958775674  484 aRSSLPSpMSAALSSQQLltAEDK 507
Cdd:PRK10263   617 -RRELAS-YGIKLPSQRA--AEEK 636
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
370-533 1.80e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 49.85  E-value: 1.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  370 GGGSRNPTPPIGRPTSTPTPPQQLPSQA-PEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVL 448
Cdd:PRK07003   368 PGGGVPARVAGAVPAPGARAAAAVGASAvPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDA 447

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  449 SGEKKEQAGQIPETAAGEPSPEPPRTSSPT-----TLPPLARSSLPSPMSAALSSQQLLTAEDKCELSSSKDDAP-PVRS 522
Cdd:PRK07003   448 PVPAKANARASADSRCDERDAQPPADSGSAsapasDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPaAAAP 527

                          170
                   ....*....|.
gi 1958775674  523 PTSCTAAPGPS 533
Cdd:PRK07003   528 PAPEARPPTPA 538
PHA03378 PHA03378
EBNA-3B; Provisional
 65-404 2.42e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 49.30  E-value: 2.42e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674   65 RALQTPAPQQIPRGPVQQPLEDRIFPPTVSAVysTVTQVARQPGPPTPSPYSAHEINKGHPNLAATPPGHASS------P 138
Cdd:PHA03378   614 HIPETSAPRQWPMPLRPIPMRPLRMQPITFNV--LVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGANTMlpiqwaP 691

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  139 GLSQTPypsgqNAGPATLVYPQAPQTMNSQPQArsPPSRAVPVHCPDNWKRRKVLEQTPVYRSLAGRGWIkyciggfrpi 218
Cdd:PHA03378   692 GTMQPP-----PRAPTPMRPPAAPPGRAQRPAA--ATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRA---------- 754

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  219 qffQRPQIQPPRAAIPNSSpslrPGAQTPTAVYQANQHIMMVNH-LPMPYPVPQGP----QYCIPQYRHSGPP--YVGPP 291
Cdd:PHA03378   755 ---RPPAAAPGRARPPAAA----PGAPTPQPPPQAPPAPQQRPRgAPTPQPPPQAGptsmQLMPRAAPGQQGPtkQILRQ 827

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  292 QQYPVQPPGPGPFYPGPGPGDFANAYGTPFYPSQPVYQ--SAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEI-- 367
Cdd:PHA03378   828 LLTGGVKRGRPSLKKPAALERQAAAGPTPSPGSGTSDKivQAPVFYPPVLQPIQVMRQLGSVRAAAASTVTQAPTEYTge 907

                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 1958775674  368 MSGGGSRNPT--PPIGRPTSTPTPPQQLPSQAPEHSPVV 404
Cdd:PHA03378   908 RRGVGPMHPTdiPPSKRAKTDAYVESQPPHGGQSHSFSV 946
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 73-286 4.27e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 48.49  E-value: 4.27e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674   73 QQIPRGPVQQPledRIFPPTVSAVYSTVTQVARQPGPPTPSPYSAHEINKGHPNLAA------TPPGHASSPglSQTPYP 146
Cdd:pfam09770  105 QQPAARAAQSS---AQPPASSLPQYQYASQQSQQPSKPVRTGYEKYKEPEPIPDLQVdaslwgVAPKKAAAP--APAPQP 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  147 SGQNAGP--------------------ATLVYPQAPQTMNSQPQARSPPSRAVPVHCPDNWKRRKVLEQTPVYRSLAGrg 206
Cdd:pfam09770  180 AAQPASLpapsrkmmsleeveaamraqAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHP-- 257

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  207 wikyciGGFRPIQFFQRPQIQPPRAAIPNSSPSLRPGAQTPTAVYQANQHIM------MVNHLPMPYPVPQGPQYCIPQY 280
Cdd:pfam09770  258 ------GQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILqnpnrlSAARVGYPQNPQPGVQPAPAHQ 331


                   ....*.
gi 1958775674  281 RHSGPP 286
Cdd:pfam09770  332 AHRQQG 337
PHA03247 PHA03247
large tegument protein UL36; Provisional
 90-497 8.31e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 8.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674   90 PPTVSAVYSTVTQVARQPGPPTPSPYSAHEINKGHPNLAATPPG---HASSPGLSQTPYPSGQNAGPAT-LVYPQAPQtm 165
Cdd:PHA03247  2628 PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGraaQASSPPQRPRRRAARPTVGSLTsLADPPPPP-- 2705

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  166 nSQPQARSPPSRAVPVHCPDNWKRRKVLEQTPVYRSLAGRGWIKYCIGGFRPIqffQRPQIQ--PPRAAIPNSSPSLRPG 243
Cdd:PHA03247  2706 -PTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARP---ARPPTTagPPAPAPPAAPAAGPPR 2781

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  244 AQTPTAVYQANQHIMMVNHLPMPYPVP---QGPQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFANAYGTP 320
Cdd:PHA03247  2782 RLTRPAVASLSESRESLPSPWDPADPPaavLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGD 2861

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  321 FYPSQPVYQSAPiiVPTQQQPPPAKREKKTIRIRDPNqggkdiTEEIMSGGGSRNPTPPIGRPTSTPTPPQQLPSQAPEH 400
Cdd:PHA03247  2862 VRRRPPSRSPAA--KPAAPARPPVRRLARPAVSRSTE------SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPP 2933

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  401 SPvvygTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPstvlrlvlsgekkeqaGQIPETAAGEPSPEPPRTSSPTTL 480
Cdd:PHA03247  2934 PP----PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVP----------------GRVAVPRFRVPQPAPSREAPASST 2993

                          410
                   ....*....|....*..
gi 1958775674  481 PPLARSSLPSPMSAALS 497
Cdd:PHA03247  2994 PPLTGHSLSRVSSWASS 3010
PHA03378 PHA03378
EBNA-3B; Provisional
 68-613 2.51e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.21  E-value: 2.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674   68 QTPAPQQIPRGPVQQPLEDRIFPPTVsavystvtQVARQPGPPTPSPYSAHEINKGHPNLAATPPGhaSSPGLSQTPYPS 147
Cdd:PHA03378   446 HSQAPTVVLHRPPTQPLEGPTGPLSV--------QAPLEPWQPLPHPQVTPVILHQPPAQGVQAHG--SMLDLLEKDDED 515

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  148 GQNAGPATLVYPQAPQTMNSQpqarsppsRAVPVHCPD-NWKRRKVLEQTPVYRSLAGRGwikycigGFRPIQFfqRPQI 226
Cdd:PHA03378   516 MEQRVMATLLPPSPPQPRAGR--------RAPCVYTEDlDIESDEPASTEPVHDQLLPAP-------GLGPLQI--QPLT 578

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  227 QPPRAAIPNSSPSlrpgaqtptavyqanqhimmvnHLPMPYPVPQGPQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYP 306
Cdd:PHA03378   579 SPTTSQLASSAPS----------------------YAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPL 636

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  307 GPGPGDFaNAYGTPfYPSQPVYQSAPIIVPTQQQPPPAKREkktirirdPNQGGKDITEEIMSGGGSRNP---TPPIGRP 383
Cdd:PHA03378   637 RMQPITF-NVLVFP-TPHQPPQVEITPYKPTWTQIGHIPYQ--------PSPTGANTMLPIQWAPGTMQPpprAPTPMRP 706

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  384 TSTPTPPQQLPSQAPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKKEQAGQIPETA 463
Cdd:PHA03378   707 PAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAP 786

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  464 A----GEPSPEPPRTSSPTTLPPLARSSLPSPMSAALSSQQLLTAEDKCELSSSKDDAPPVR-SPTSCTAAPGPSLTDDI 538
Cdd:PHA03378   787 QqrprGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERqAAAGPTPSPGSGTSDKI 866

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  539 glCKKPCGVAPpdgqlVSSPVLIneMNGVGEKLPAKENTVDMV-------RQEVLPLTLElEILehPQEERKVECTPTPI 611
Cdd:PHA03378   867 --VQAPVFYPP-----VLQPIQV--MRQLGSVRAAAASTVTQApteytgeRRGVGPMHPT-DIP--PSKRAKTDAYVESQ 934


                   ..
gi 1958775674  612 TP 613
Cdd:PHA03378   935 PP 936
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 62-440 3.16e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.91  E-value: 3.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674   62 PNIRALQTPAPQQIPR-GPVQQPLEDRIFPPTVSAvYSTVTQVARQPGPPTPSPYSAHEINKGHPnLAATPPGHASSPGL 140
Cdd:pfam03154  229 TLIQQTPTLHPQRLPSpHPPLQPMTQPPPPSQVSP-QPLPQPSLHGQMPPMPHSLQTGPSHMQHP-VPPQPFPLTPQSSQ 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  141 SQTP-YPSGQNAGPATlvypQAPQTMNSQPQARSP-PSRAVPV-HCPDNWKRRKVLEQTPVyRSLAGRGWIKYCIGGFRP 217
Cdd:pfam03154  307 SQVPpGPSPAAPGQSQ----QRIHTPPSQSQLQSQqPPREQPLpPAPLSMPHIKPPPTTPI-PQLPNPQSHKHPPHLSGP 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  218 IQFFQRPQIQPPraaipnssPSLRPGAQTPTavyqanqhimmvNHLPMPYPvpqGPQYCIPQYRHSGPPyvgppqqypvq 297
Cdd:pfam03154  382 SPFQMNSNLPPP--------PALKPLSSLST------------HHPPSAHP---PPLQLMPQSQQLPPP----------- 427

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  298 ppgpgpfypgpgpgdfanaygtpfyPSQPvyqsaPIIVPTQQQPPPAKREKKTIRIRD-PNQggKDITEEIMSGGGSRNP 376
Cdd:pfam03154  428 -------------------------PAQP-----PVLTQSQSLPPPAASHPPTSGLHQvPSQ--SPFPQHPFVPGGPPPI 475

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958775674  377 TPPIGRPTSTPT--PPQQLPSQAPEHSPVVYGTVESAHLAASTPVTAASDQKQE-EKPKPDPVFQSP 440
Cdd:pfam03154  476 TPPSGPPTSTSSamPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEpESPPPPPRSPSP 542
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 100-549 4.32e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.14  E-value: 4.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  100 VTQVARQPGPPTPSPY---------SAHEINKGHPNLAATPPGHASSPGLSQTPYPSGQNAGPAtlvyPQAPqtmnSQPQ 170
Cdd:pfam03154  137 IDQDNRSTSPSIPSPQdnesdsdssAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPT----PSAP----SVPP 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  171 ARSPPSRAVPVHCPDNWKRRKVLEQTPVYRSlagrgwikyciggfrpiqffQR-PQIQPPRAAIPNSSPslrPGAQTPTA 249
Cdd:pfam03154  209 QGSPATSQPPNQTQSTAAPHTLIQQTPTLHP--------------------QRlPSPHPPLQPMTQPPP---PSQVSPQP 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  250 VYQANQHIMMVnhlPMPYPVPQGPqyciPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFANAYgTPfyPSQPVYQ 329
Cdd:pfam03154  266 LPQPSLHGQMP---PMPHSLQTGP----SHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIH-TP--PSQSQLQ 335

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  330 SAPiivPTQQQP-PPAKRekktirirdpnqggkditeeimsgggsrnPTPPIGRPTSTPTPPQQLPsQAPEHSPvvygtv 408
Cdd:pfam03154  336 SQQ---PPREQPlPPAPL-----------------------------SMPHIKPPPTTPIPQLPNP-QSHKHPP------ 376

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  409 esaHLAASTPVTAASDQKQEEKPKPD---PVFQSPST---VLRLVlsgekkEQAGQIPEtaagePSPEPPRTSSPTTLPP 482
Cdd:pfam03154  377 ---HLSGPSPFQMNSNLPPPPALKPLsslSTHHPPSAhppPLQLM------PQSQQLPP-----PPAQPPVLTQSQSLPP 442

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958775674  483 LArSSLPSPMSAALSSQQLLTAEDKCELSSSKDDAPPVRSPTSCTAApGPSLtddiglcKKPCGVAP 549
Cdd:pfam03154  443 PA-ASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSA-MPGI-------QPPSSASV 500
PRK11901 PRK11901
hypothetical protein; Reviewed
 323-450 4.39e-04

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 44.67  E-value: 4.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  323 PSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDP---------NQGGKDITEEIMSGGGSRNPTPPIGRPTSTPTPPQQL 393
Cdd:PRK11901   113 TAPPQDISAPPISPTPTQAAPPQTPNGQQRIELPgnisdalsqQQGQVNAASQNAQGNTSTLPTAPATVAPSKGAKVPAT 192

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  394 PSQAPEHSPVVYGT--VESAHLAASTPVTAASDQKQEEKPKPDPVFQS-PSTVLRLVLSG 450
Cdd:PRK11901   193 AETHPTPPQKPATKkpAVNHHKTATVAVPPATSGKPKSGAASARALSSaPASHYTLQLSS 252
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
319-505 1.68e-03

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 42.73  E-value: 1.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  319 TPFYPSQpvyqsapiiVPTQQQPPPAKREKKTIRIRDPNQGgkditeeimSGGGSRNPTPPIGRPTSTPTPPQQLPSQAP 398
Cdd:pfam05539  186 HPTYPSQ---------VTPQSQPATQGHQTATANQRLSSTE---------PVGTQGTTTSSNPEPQTEPPPSQRGPSGSP 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  399 EHSPvvygtvesahlaaSTP----VTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKKeqagqiPETAAGEPSPEPPRT 474
Cdd:pfam05539  248 QHPP-------------STTsqdqSTTGDGQEHTQRRKTPPATSNRRSPHSTATPPPTT------KRQETGRPTPRPTAT 308

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1958775674  475 SSPTTLPPlarSSLPSPMSAALSSQQLLTAE 505
Cdd:pfam05539  309 TQSGSSPP---HSSPPGVQANPTTQNLVDCK 336
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 339-534 3.48e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 3.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  339 QQPPPAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPPIGRPTSTPTPPQQLPSQAPEHSPVVYGTVESAHlaASTP 418
Cdd:PHA03307    69 TGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVG--SPGP 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  419 VTAASDQKQEEKPKPDPVFQSPSTVLRLVLSgekkeqAGQIPETAAGEPSPEPPRTSSPTTLPPlaRSSLPSPMSA--AL 496
Cdd:PHA03307   147 PPAASPPAAGASPAAVASDAASSRQAALPLS------SPEETARAPSSPPAEPPPSTPPAAASP--RPPRRSSPISasAS 218

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1958775674  497 SSQQLLTAEDKCELSSSKDDAPPVRS------PTSCTAAPGPSL 534
Cdd:PHA03307   219 SPAPAPGRSAADDAGASSSDSSSSESsgcgwgPENECPLPRPAP 262
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
323-519 5.29e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.76  E-value: 5.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  323 PSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPPigrPTSTPTPPQQLPSQAPEHSP 402
Cdd:PRK07003   467 DAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPA---AAAPPAPEARPPTPAAAAPA 543

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  403 vvygtvesahlAASTPVTAASDqkqeekpkpdpvfqspstVLR---LVLSGEKKEQAGQIPETAAGEPSPEPPRTSSPTT 479
Cdd:PRK07003   544 -----------ARAGGAAAALD------------------VLRnagMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAV 594

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1958775674  480 LPPLARSSLPSPMSAALSSQQLLTAEDKCELSSSKDDAPP 519
Cdd:PRK07003   595 QVPTPRARAATGDAPPNGAARAEQAAESRGAPPPWEDIPP 634
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 244-539 6.80e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.61  E-value: 6.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  244 AQTPTAVYQAN-QHIMMVNHLPMPYPVPQGPQY---CIPQYrHSGPPYVGPPQQYpvqppgpgpFYPGPGPGDFANAYGT 319
Cdd:PRK10263   326 ATTATQSWAAPvEPVTQTPPVASVDVPPAQPTVawqPVPGP-QTGEPVIAPAPEG---------YPQQSQYAQPAVQYNE 395

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  320 PFypSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPpigRPTSTPTPPQQLPSQAPE 399
Cdd:PRK10263   396 PL--QQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQ---QSTFAPQSTYQTEQTYQQ 470

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775674  400 hsPVVYGTVESAHLAASTPVTAASDQKQEE-KPKPDPVFQSPSTVLRlvlSGEKKEQAGQ----IPETAAgEPSPEPPRT 474
Cdd:PRK10263   471 --PAAQEPLYQQPQPVEQQPVVEPEPVVEEtKPARPPLYYFEEVEEK---RAREREQLAAwyqpIPEPVK-EPEPIKSSL 544

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958775674  475 S--SPTTLPPLARSSLPSPMSAALSSQQLLTaedkcelSSSKDDAPPVRSPTScTAAPGPSLTDDIG 539
Cdd:PRK10263   545 KapSVAAVPPVEAAAAVSPLASGVKKATLAT-------GAAATVAAPVFSLAN-SGGPRPQVKEGIG 603
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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