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Conserved domains on  [gi|1958645194|ref|XP_038966756|]
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zinc finger protein 51 isoform X1 [Rattus norvegicus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-53 2.66e-21

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 87.26  E-value: 2.66e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1958645194   13 LTFRDVAVDFSQEEWECLASPQRALYIDVMLENYSNLVSVE 53
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
210-546 1.16e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 1.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645194 210 NKPYKCNICDKSFtqcsSLKTHRKTHQRLRAGTKPYKCSD--CEKSFSYLSALKSHQKRHTGEKRYkckECDKSYAYRTG 287
Cdd:COG5048    31 PRPDSCPNCTDSF----SRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD---LNSKSLPLSNS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645194 288 LKRHQKIHTAKErYSCQHCGKVFHQLSHFKSHFTVHSAEKPYKC-NECHRSFPHYVFFRRHKKNHSLQKSHKCKECGKSF 366
Cdd:COG5048   104 KASSSSLSSSSS-NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLrNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645194 367 FILSHlkTHYRIHTGEKPYKCTECDKSFTQYSHLRRHQRIYTGKKLYRCEVCDKWFTMSSSLSRHQKIHTEAKTYKCKDC 446
Cdd:COG5048   183 NLSLL--ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645194 447 DIFFTHYSSLRRHQRVHTGE--------KHTCKQCGKSFTRGSTLRAHQR--IHTGE--KPYKC--SKCDKSFIQASQLR 512
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSssekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALK 340

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1958645194 513 THQRVHTGERPYVCK--ECGKSLTTCAILRAHQKIH 546
Cdd:COG5048   341 RHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQ 376
zf-H2C2_2 pfam13465
Zinc-finger double domain;
539-563 8.06e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.06e-03
                          10        20
                  ....*....|....*....|....*
gi 1958645194 539 LRAHQKIHTGEKPYKCMECGKSYIQ 563
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-53 2.66e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 87.26  E-value: 2.66e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1958645194   13 LTFRDVAVDFSQEEWECLASPQRALYIDVMLENYSNLVSVE 53
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 2.77e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 2.77e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958645194  12 LLTFRDVAVDFSQEEWECLASPQRALYIDVMLENYSNLVSV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 1.73e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 1.73e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958645194  13 LTFRDVAVDFSQEEWECLASPQRALYIDVMLENYSNLVS 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
210-546 1.16e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 1.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645194 210 NKPYKCNICDKSFtqcsSLKTHRKTHQRLRAGTKPYKCSD--CEKSFSYLSALKSHQKRHTGEKRYkckECDKSYAYRTG 287
Cdd:COG5048    31 PRPDSCPNCTDSF----SRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD---LNSKSLPLSNS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645194 288 LKRHQKIHTAKErYSCQHCGKVFHQLSHFKSHFTVHSAEKPYKC-NECHRSFPHYVFFRRHKKNHSLQKSHKCKECGKSF 366
Cdd:COG5048   104 KASSSSLSSSSS-NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLrNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645194 367 FILSHlkTHYRIHTGEKPYKCTECDKSFTQYSHLRRHQRIYTGKKLYRCEVCDKWFTMSSSLSRHQKIHTEAKTYKCKDC 446
Cdd:COG5048   183 NLSLL--ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645194 447 DIFFTHYSSLRRHQRVHTGE--------KHTCKQCGKSFTRGSTLRAHQR--IHTGE--KPYKC--SKCDKSFIQASQLR 512
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSssekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALK 340

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1958645194 513 THQRVHTGERPYVCK--ECGKSLTTCAILRAHQKIH 546
Cdd:COG5048   341 RHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQ 376
zf-H2C2_2 pfam13465
Zinc-finger double domain;
371-396 3.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.58e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958645194 371 HLKTHYRIHTGEKPYKCTECDKSFTQ 396
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
539-563 8.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.06e-03
                          10        20
                  ....*....|....*....|....*
gi 1958645194 539 LRAHQKIHTGEKPYKCMECGKSYIQ 563
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-53 2.66e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 87.26  E-value: 2.66e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1958645194   13 LTFRDVAVDFSQEEWECLASPQRALYIDVMLENYSNLVSVE 53
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 2.77e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 2.77e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958645194  12 LLTFRDVAVDFSQEEWECLASPQRALYIDVMLENYSNLVSV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 1.73e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 1.73e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958645194  13 LTFRDVAVDFSQEEWECLASPQRALYIDVMLENYSNLVS 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
210-546 1.16e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 1.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645194 210 NKPYKCNICDKSFtqcsSLKTHRKTHQRLRAGTKPYKCSD--CEKSFSYLSALKSHQKRHTGEKRYkckECDKSYAYRTG 287
Cdd:COG5048    31 PRPDSCPNCTDSF----SRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD---LNSKSLPLSNS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645194 288 LKRHQKIHTAKErYSCQHCGKVFHQLSHFKSHFTVHSAEKPYKC-NECHRSFPHYVFFRRHKKNHSLQKSHKCKECGKSF 366
Cdd:COG5048   104 KASSSSLSSSSS-NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLrNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645194 367 FILSHlkTHYRIHTGEKPYKCTECDKSFTQYSHLRRHQRIYTGKKLYRCEVCDKWFTMSSSLSRHQKIHTEAKTYKCKDC 446
Cdd:COG5048   183 NLSLL--ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645194 447 DIFFTHYSSLRRHQRVHTGE--------KHTCKQCGKSFTRGSTLRAHQR--IHTGE--KPYKC--SKCDKSFIQASQLR 512
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSssekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALK 340

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1958645194 513 THQRVHTGERPYVCK--ECGKSLTTCAILRAHQKIH 546
Cdd:COG5048   341 RHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQ 376
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 209-268 5.88e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.95  E-value: 5.88e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958645194 209 GNKPYKCNI--CDKSFTQCSSLKTHRK---------------THQRLRAGTKPYKCSDCEKSFSYLSALKSHQKRHT 268
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspeKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
120-532 1.58e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645194 120 HKSTHTGEEP--CTSEDCEKSFDLCSNITQDQTFYTEEKEHRQEK--HDDHFSSTYSLMQQSIYIGANAGQCVKYGKCFS 195
Cdd:COG5048    52 HIRSHTGEKPsqCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKslPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPS 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645194 196 IASslsiQQRIDTGnkpYKCNICDKSFTQCSSLKTHRKTHQRLRAGTKPYkcSDCEKSFSYLSALKSHQKRHTGEKRYKC 275
Cdd:COG5048   132 SRD----PQLPDLL---SISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN--SLSKDPSSNLSLLISSNVSTSIPSSSEN 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645194 276 KECDKSYAYRTGLkRHQKIHTAKERYSCQHCGKVFHQLSHFKSHFTVHSAEKPYKCNECHRSFPHYVFFRRHKKNHSLQK 355
Cdd:COG5048   203 SPLSSSYSIPSSS-SDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSS 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645194 356 SHKCKEcgksffilshlkthyrihtgeKPYKCTECDKSFTQYSHLRRHQR--IYTGKKLYRC----EVCDKWFTMSSSLS 429
Cdd:COG5048   282 SEKGFS---------------------LPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFscpySLCGKLFSRNDALK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645194 430 RHQKIHTEAKTYKCKDC------DIFFTHYSSLRRHQRV--HTGEKHTC--KQCGKSFTRGSTLRAHQRIHTGEKP--YK 497
Cdd:COG5048   341 RHILLHTSISPAKEKLLnssskfSPLLNNEPPQSLQQYKdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1958645194 498 CSKCDKSFIQASQLRTHQRVHTGERPYVCKECGKS 532
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSF 455
zf-H2C2_2 pfam13465
Zinc-finger double domain;
371-396 3.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.58e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958645194 371 HLKTHYRIHTGEKPYKCTECDKSFTQ 396
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
347-416 1.60e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.60e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958645194 347 HKKNHSLQKSHKCKECGKSFFILSHLKTHYRIHTGEKPYKCT--ECDKSFTQYSHLRRHQRIYTGKKLYRCE 416
Cdd:COG5048    24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS 95
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 492-572 1.61e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645194 492 GEKPYKCS--KCDKSFIQASQLRTHqRVHtgerpyvcKECGKSLTTCAILRAHQKIHTGEKPYKCMECGKSYIQYSHLKR 569
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1958645194 570 HQK 572
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
483-507 2.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.16e-03
                          10        20
                  ....*....|....*....|....*
gi 1958645194 483 LRAHQRIHTGEKPYKCSKCDKSFIQ 507
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
259-284 3.75e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958645194 259 ALKSHQKRHTGEKRYKCKECDKSYAY 284
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
539-563 8.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.06e-03
                          10        20
                  ....*....|....*....|....*
gi 1958645194 539 LRAHQKIHTGEKPYKCMECGKSYIQ 563
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 269-353 8.37e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 8.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645194 269 GEKRYKCK--ECDKSYAYRTGLKRHqKIHTakeryscqHCGKVFHQLSHFKSHFTVHSAEKPYKCNECHRSFPHYVFFRR 346
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*..
gi 1958645194 347 HKKNHSL 353
Cdd:COG5189   417 HRKHSHD 423
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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