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Conserved domains on  [gi|1958645899|ref|XP_038969117|]
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tsukushi isoform X1 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-306 1.98e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899  85 TTLAGLDLSHNLLTSItPTAFSRLRYLESLDLSHNGLAALPAEVFTSSPLSDINLSHNRLREVSISAftthSQGRAL-HV 163
Cdd:COG4886   113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEEL----GNLTNLkEL 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899 164 DLSHNLIHRLlpypaRASLSAPT-IQSLNLSWNRLRAVP-NLRDLP-LRYLSLDGNPLATInpGAFMGLAGLTHLSLASL 240
Cdd:COG4886   188 DLSNNQITDL-----PEPLGNLTnLEELDLSGNQLTDLPePLANLTnLETLDLSNNQLTDL--PELGNLTNLEELDLSNN 260

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899 241 QgILQLPPHGfrELPGLQVLDLSGNP----KLKWAGAEVFSGLGLLQELDLSGSSLVPLPETLLHHLPAL 306
Cdd:COG4886   261 Q-LTDLPPLA--NLTNLKTLDLSNNQltdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLL 327
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-306 1.98e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899  85 TTLAGLDLSHNLLTSItPTAFSRLRYLESLDLSHNGLAALPAEVFTSSPLSDINLSHNRLREVSISAftthSQGRAL-HV 163
Cdd:COG4886   113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEEL----GNLTNLkEL 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899 164 DLSHNLIHRLlpypaRASLSAPT-IQSLNLSWNRLRAVP-NLRDLP-LRYLSLDGNPLATInpGAFMGLAGLTHLSLASL 240
Cdd:COG4886   188 DLSNNQITDL-----PEPLGNLTnLEELDLSGNQLTDLPePLANLTnLETLDLSNNQLTDL--PELGNLTNLEELDLSNN 260

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899 241 QgILQLPPHGfrELPGLQVLDLSGNP----KLKWAGAEVFSGLGLLQELDLSGSSLVPLPETLLHHLPAL 306
Cdd:COG4886   261 Q-LTDLPPLA--NLTNLKTLDLSNNQltdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLL 327
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 64-175 3.24e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.32  E-value: 3.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899  64 LDLSSNRLETVNESVLGGpgYTTLAGLDLSHNLLTSITPTAFSRLRYLESLDLSHNGLAALPAEVFTSSP-LSDINLSHN 142
Cdd:PLN00113  480 LDLSRNQFSGAVPRKLGS--LSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPvLSQLDLSQN 557

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958645899 143 RLrevsiSAFTTHSQGRA---LHVDLSHNLIHRLLP 175
Cdd:PLN00113  558 QL-----SGEIPKNLGNVeslVQVNISHNHLHGSLP 588
LRR_8 pfam13855
Leucine rich repeat;
90-144 1.96e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 1.96e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958645899  90 LDLSHNLLTSITPTAFSRLRYLESLDLSHNGLAALPAEVFTSSP-LSDINLSHNRL 144
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 60-275 9.95e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 9.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899  60 DTAHLDLSSNRLETVNESV-LGGPGYTTLAGL---DLSHNLLTSITPTAFSRLR---YLESLDLSHNGLA----ALPAEV 128
Cdd:cd00116    52 SLKELCLSLNETGRIPRGLqSLLQGLTKGCGLqelDLSDNALGPDGCGVLESLLrssSLQELKLNNNGLGdrglRLLAKG 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899 129 FTSSP--LSDINLSHNRL-REVSISAFTTHSQGRALH-VDLSHNLI-HRLLPYPARASLSAPTIQSLNLSWNRLR----- 198
Cdd:cd00116   132 LKDLPpaLEKLVLGRNRLeGASCEALAKALRANRDLKeLNLANNGIgDAGIRALAEGLKANCNLEVLDLNNNGLTdegas 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899 199 ----AVPNLRDLplRYLSLDGNPL-----ATINPGAFMGLAGLTHLSLAS----LQGILQLPpHGFRELPGLQVLDLSGN 265
Cdd:cd00116   212 alaeTLASLKSL--EVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCnditDDGAKDLA-EVLAEKESLLELDLRGN 288

                         250
                  ....*....|
gi 1958645899 266 pKLKWAGAEV 275
Cdd:cd00116   289 -KFGEEGAQL 297
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-306 1.98e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899  85 TTLAGLDLSHNLLTSItPTAFSRLRYLESLDLSHNGLAALPAEVFTSSPLSDINLSHNRLREVSISAftthSQGRAL-HV 163
Cdd:COG4886   113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEEL----GNLTNLkEL 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899 164 DLSHNLIHRLlpypaRASLSAPT-IQSLNLSWNRLRAVP-NLRDLP-LRYLSLDGNPLATInpGAFMGLAGLTHLSLASL 240
Cdd:COG4886   188 DLSNNQITDL-----PEPLGNLTnLEELDLSGNQLTDLPePLANLTnLETLDLSNNQLTDL--PELGNLTNLEELDLSNN 260

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899 241 QgILQLPPHGfrELPGLQVLDLSGNP----KLKWAGAEVFSGLGLLQELDLSGSSLVPLPETLLHHLPAL 306
Cdd:COG4886   261 Q-LTDLPPLA--NLTNLKTLDLSNNQltdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLL 327
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-311 1.24e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 1.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899  34 LFDSFSLIRVDCSSLGPHIVPVPIPLDTAHLDLSSNRLETVNESVLGGPGYTTLAGLDLSHNLLTSITPTAFSRLRYLES 113
Cdd:COG4886    21 LTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899 114 LDLSHNglaalpAEVFTSSPLSDINLSHNRLRE--VSISAFTthsqgrAL-HVDLSHNLIHRLLPyparaSLSA-PTIQS 189
Cdd:COG4886   101 LDLSGN------EELSNLTNLESLDLSGNQLTDlpEELANLT------NLkELDLSNNQLTDLPE-----PLGNlTNLKS 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899 190 LNLSWNRLRAVPN-LRDLP-LRYLSLDGNPLATInPGAFMGLAGLTHLSLASLQgiLQLPPHGFRELPGLQVLDLSGNP- 266
Cdd:COG4886   164 LDLSNNQLTDLPEeLGNLTnLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQ--LTDLPEPLANLTNLETLDLSNNQl 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1958645899 267 -KLKWagaevFSGLGLLQELDLSGSSLVPLPEtlLHHLPALQSVSV 311
Cdd:COG4886   241 tDLPE-----LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDL 279
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 64-175 3.24e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.32  E-value: 3.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899  64 LDLSSNRLETVNESVLGGpgYTTLAGLDLSHNLLTSITPTAFSRLRYLESLDLSHNGLAALPAEVFTSSP-LSDINLSHN 142
Cdd:PLN00113  480 LDLSRNQFSGAVPRKLGS--LSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPvLSQLDLSQN 557

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958645899 143 RLrevsiSAFTTHSQGRA---LHVDLSHNLIHRLLP 175
Cdd:PLN00113  558 QL-----SGEIPKNLGNVeslVQVNISHNHLHGSLP 588
LRR_8 pfam13855
Leucine rich repeat;
90-144 1.96e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 1.96e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958645899  90 LDLSHNLLTSITPTAFSRLRYLESLDLSHNGLAALPAEVFTSSP-LSDINLSHNRL 144
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
64-121 2.10e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 2.10e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958645899  64 LDLSSNRLETVNESVLGGPgyTTLAGLDLSHNLLTSITPTAFSRLRYLESLDLSHNGL 121
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGL--SNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
208-266 2.84e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 2.84e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958645899 208 LRYLSLDGNPLATINPGAFMGLAGLTHLSLASLQgILQLPPHGFRELPGLQVLDLSGNP 266
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL-LTTLSPGAFSGLPSLRYLDLSGNR 60
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
53-221 3.33e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 3.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899  53 VPVPIPLDTAHLDLSSNRLETVNESVlggPgyTTLAGLDLSHNLLTSITPTAFSRLRYlesLDLSHNGLAALPAEVftSS 132
Cdd:PRK15370  235 IPATLPDTIQEMELSINRITELPERL---P--SALQSLDLFHNKISCLPENLPEELRY---LSVYDNSIRTLPAHL--PS 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899 133 PLSDINLSHNRLR-------------EVSISAFTT--HSQGRALHV-DLSHNLIHRL---LPyparaslsaPTIQSLNLS 193
Cdd:PRK15370  305 GITHLNVQSNSLTalpetlppglktlEAGENALTSlpASLPPELQVlDVSKNQITVLpetLP---------PTITTLDVS 375

                         170       180       190
                  ....*....|....*....|....*....|
gi 1958645899 194 WNRLRAVPnlRDLP--LRYLSLDGNPLATI 221
Cdd:PRK15370  376 RNALTNLP--ENLPaaLQIMQASRNNLVRL 403
LRR_8 pfam13855
Leucine rich repeat;
185-239 1.88e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 1.88e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958645899 185 PTIQSLNLSWNRLRAVP--NLRDLP-LRYLSLDGNPLATINPGAFMGLAGLTHLSLAS 239
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgAFKGLSnLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
LRR_8 pfam13855
Leucine rich repeat;
231-292 3.82e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 3.82e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958645899 231 GLTHLSLASlQGILQLPPHGFRELPGLQVLDLSGNpKLKWAGAEVFSGLGLLQELDLSGSSL 292
Cdd:pfam13855   2 NLRSLDLSN-NRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 87-299 4.38e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 4.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899  87 LAGLDLS-HNLLTSITPTAFsRLRYLESLDLSHNGLAA-LPAEVF-TSSPLSDINLSHNRlrevsisaFTThsqgralhv 163
Cdd:PLN00113   71 VVSIDLSgKNISGKISSAIF-RLPYIQTINLSNNQLSGpIPDDIFtTSSSLRYLNLSNNN--------FTG--------- 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899 164 dlshnlihrllPYParaSLSAPTIQSLNLSWNRLRA-VPNLRDL--PLRYLSLDGNPLATINPGAFMGLAGLTHLSLASL 240
Cdd:PLN00113  133 -----------SIP---RGSIPNLETLDLSNNMLSGeIPNDIGSfsSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASN 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958645899 241 QGILQLPphgfRELPGLQVLdlsgnpKLKWAGAEVFSG--------LGLLQELDLSGSSLV-PLPETL 299
Cdd:PLN00113  199 QLVGQIP----RELGQMKSL------KWIYLGYNNLSGeipyeiggLTSLNHLDLVYNNLTgPIPSSL 256
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 60-275 9.95e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 9.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899  60 DTAHLDLSSNRLETVNESV-LGGPGYTTLAGL---DLSHNLLTSITPTAFSRLR---YLESLDLSHNGLA----ALPAEV 128
Cdd:cd00116    52 SLKELCLSLNETGRIPRGLqSLLQGLTKGCGLqelDLSDNALGPDGCGVLESLLrssSLQELKLNNNGLGdrglRLLAKG 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899 129 FTSSP--LSDINLSHNRL-REVSISAFTTHSQGRALH-VDLSHNLI-HRLLPYPARASLSAPTIQSLNLSWNRLR----- 198
Cdd:cd00116   132 LKDLPpaLEKLVLGRNRLeGASCEALAKALRANRDLKeLNLANNGIgDAGIRALAEGLKANCNLEVLDLNNNGLTdegas 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899 199 ----AVPNLRDLplRYLSLDGNPL-----ATINPGAFMGLAGLTHLSLAS----LQGILQLPpHGFRELPGLQVLDLSGN 265
Cdd:cd00116   212 alaeTLASLKSL--EVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCnditDDGAKDLA-EVLAEKESLLELDLRGN 288

                         250
                  ....*....|
gi 1958645899 266 pKLKWAGAEV 275
Cdd:cd00116   289 -KFGEEGAQL 297
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 64-299 1.04e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899  64 LDLSSNRLETVNESVLGGpgYTTLAGLDLSHNLLTSITPTAFSRLRYLESLDLSHNGLAA-LPAEVFTSSPLSDINLSHN 142
Cdd:PLN00113  145 LDLSNNMLSGEIPNDIGS--FSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGqIPRELGQMKSLKWIYLGYN 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899 143 RLR---EVSISAFTTHSqgralHVDLSHNlihrllpyparaSLSAPTIQSLNlswnrlravpNLRDlpLRYLSLDGNPLA 219
Cdd:PLN00113  223 NLSgeiPYEIGGLTSLN-----HLDLVYN------------NLTGPIPSSLG----------NLKN--LQYLFLYQNKLS 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899 220 TINPGAFMGLAGLTHLSLA--SLQG-----ILQLP----------------PHGFRELPGLQVLDLSGNpklKWAGaEVF 276
Cdd:PLN00113  274 GPIPPSIFSLQKLISLDLSdnSLSGeipelVIQLQnleilhlfsnnftgkiPVALTSLPRLQVLQLWSN---KFSG-EIP 349

                         250       260
                  ....*....|....*....|....*..
gi 1958645899 277 SGLGL---LQELDLSGSSLV-PLPETL 299
Cdd:PLN00113  350 KNLGKhnnLTVLDLSTNNLTgEIPEGL 376
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 64-265 1.17e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899  64 LDLSSNRLETVNESVLGGPGYttLAGLDLSHNLLTSITPTAFSRLRYLESLDLSHNGLAA-LPAEvFTSSPLSD-INLSH 141
Cdd:PLN00113  361 LDLSTNNLTGEIPEGLCSSGN--LFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGeLPSE-FTKLPLVYfLDISN 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899 142 NRLREVSISAFTTHSQGRALhvDLSHNLIHRLLPYPARASlsapTIQSLNLSWNRLR-AVPN-LRDLP-LRYLSLDGNPL 218
Cdd:PLN00113  438 NNLQGRINSRKWDMPSLQML--SLARNKFFGGLPDSFGSK----RLENLDLSRNQFSgAVPRkLGSLSeLMQLKLSENKL 511

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1958645899 219 ATINPGAFMGLAGLTHLSLASLQGILQLPPhGFRELPGLQVLDLSGN 265
Cdd:PLN00113  512 SGEIPDELSSCKKLVSLDLSHNQLSGQIPA-SFSEMPVLSQLDLSQN 557
LRR_8 pfam13855
Leucine rich repeat;
109-170 2.52e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 2.52e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958645899 109 RYLESLDLSHNGLAALPAEVFTS-SPLSDINLSHNRLREVSISAFtthSQGRAL-HVDLSHNLI 170
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGlSNLKVLDLSNNLLTTLSPGAF---SGLPSLrYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
53-149 3.54e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 42.38  E-value: 3.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899  53 VPVPIPLDTAHLDLSSNRLETVNESVlggPgyTTLAGLDLSHNLLTSITPTAFSRLRYLESldlSHNGLAALPAEV--FT 130
Cdd:PRK15370  340 LPASLPPELQVLDVSKNQITVLPETL---P--PTITTLDVSRNALTNLPENLPAALQIMQA---SRNNLVRLPESLphFR 411

                          90       100
                  ....*....|....*....|..
gi 1958645899 131 S---SPlSDINLSHNRLREVSI 149
Cdd:PRK15370  412 GegpQP-TRIIVEYNPFSERTI 432
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-221 6.27e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 6.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899  90 LDLSHNLLTSITPtaFSRLRYLESLDLSHN------GLAALPAevftsspLSDINLSHNRLRE---VSISAFTTHSQGRA 160
Cdd:cd21340    51 LYLQNNQIEKIEN--LENLVNLKKLYLGGNrisvveGLENLTN-------LEELHIENQRLPPgekLTFDPRSLAALSNS 121

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958645899 161 LHV-DLSHNLIHRLLPYparASLSAptIQSLNLSWNRLRAVPNLRDL-----PLRYLSLDGNPLATI 221
Cdd:cd21340   122 LRVlNISGNNIDSLEPL---APLRN--LEQLDASNNQISDLEELLDLlsswpSLRELDLTGNPVCKK 183
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 90-215 7.65e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.37  E-value: 7.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899  90 LDLSHNLLTSITPTAFSRLRYLESLDLSHNGLAALPAEVFTSSPLSDINLSHNRLREVSISAFTTHSQgrALHVDLSHNL 169
Cdd:PLN00113  433 LDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSE--LMQLKLSENK 510

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958645899 170 IHRLLPypaRASLSAPTIQSLNLSWNRLRA--------VPNLRDLPLRYLSLDG 215
Cdd:PLN00113  511 LSGEIP---DELSSCKKLVSLDLSHNQLSGqipasfseMPVLSQLDLSQNQLSG 561
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-213 8.03e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 8.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899  63 HLDLSSNRLETVNEsvLGGPgyTTLAGLDLSHNLLTSITPTAfsRLRYLESLDLSHNGLAALPAEVFTSSPLSDINLSHN 142
Cdd:COG4886   232 TLDLSNNQLTDLPE--LGNL--TNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958645899 143 RLREVSISAFTTHSQGRALHVDLSHNLIHRLLPYPARASLSAPTIQSLNLSWNRLRAVPNLRDLPLRYLSL 213
Cdd:COG4886   306 LLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLE 376
LRR_8 pfam13855
Leucine rich repeat;
255-308 1.44e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 1.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958645899 255 PGLQVLDLSGNpKLKWAGAEVFSGLGLLQELDLSGSSLVPLPETLLHHLPALQS 308
Cdd:pfam13855   1 PNLRSLDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRY 53
PLN03150 PLN03150
hypothetical protein; Provisional
 89-144 4.10e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.03  E-value: 4.10e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958645899  89 GLDLSHNLLTSITPTAFSRLRYLESLDLSHNGL-AALPAEVFTSSPLSDINLSHNRL 144
Cdd:PLN03150  422 GLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIrGNIPPSLGSITSLEVLDLSYNSF 478
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 63-125 4.61e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 4.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958645899  63 HLDLSSNRLETVNE-SVLggpgyTTLAGLDLSHNLLTSITPTA--FSRLRYLESLDLSHNGLAALP 125
Cdd:cd21340   124 VLNISGNNIDSLEPlAPL-----RNLEQLDASNNQISDLEELLdlLSSWPSLRELDLTGNPVCKKP 184
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 83-197 8.96e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 37.85  E-value: 8.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645899  83 GYTTLAGLDLSHNLLT----SITPTAFSRLRYLESLDLSHN-----GLAALPAEVFTSSPLSDINLSHNRLREVSISAFT 153
Cdd:COG5238   234 GNKSLTTLDLSNNQIGdegvIALAEALKNNTTVETLYLSGNqigaeGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALA 313

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958645899 154 THSQGRA-LHV-DLSHNLIH----RLLpypARASLSAPTIQSLNLSWNRL 197
Cdd:COG5238   314 EGLQGNKtLHTlNLAYNGIGaqgaIAL---AKALQENTTLHSLDLSDNQI 360
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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