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Conserved domains on  [gi|47576081|ref|NP_001000162|]
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olfactory receptor Olr140 [Rattus norvegicus]

Protein Classification

olfactory receptor family 51 protein( domain architecture ID 11607012)

olfactory receptor family 51 protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
28-301 1.57e-153

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320350  Cd Length: 275  Bit Score: 430.77  E-value: 1.57e-153
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  28 WISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLH 107
Cdd:cd15222   2 WISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 108 GFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMI 187
Cdd:cd15222  82 TFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVM 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 188 HLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRFA 267
Cdd:cd15222 162 KLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFG 241
                       250       260       270
                ....*....|....*....|....*....|....
gi 47576081 268 KHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQI 301
Cdd:cd15222 242 KHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
 
Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
28-301 1.57e-153

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 430.77  E-value: 1.57e-153
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  28 WISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLH 107
Cdd:cd15222   2 WISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 108 GFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMI 187
Cdd:cd15222  82 TFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVM 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 188 HLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRFA 267
Cdd:cd15222 162 KLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFG 241
                       250       260       270
                ....*....|....*....|....*....|....
gi 47576081 268 KHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQI 301
Cdd:cd15222 242 KHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
34-309 3.08e-98

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 290.94  E-value: 3.08e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081    34 FCL-YTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:pfam13853   1 FCLmYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081   113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVCA 192
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081   193 DIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRFAKHASP 272
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPP 240
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 47576081   273 LVHVLMANIYLLAPPVMNPIIYSAKTKQIRQGITHLL 309
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
 
Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
28-301 1.57e-153

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 430.77  E-value: 1.57e-153
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  28 WISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLH 107
Cdd:cd15222   2 WISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 108 GFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMI 187
Cdd:cd15222  82 TFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVM 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 188 HLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRFA 267
Cdd:cd15222 162 KLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFG 241
                       250       260       270
                ....*....|....*....|....*....|....
gi 47576081 268 KHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQI 301
Cdd:cd15222 242 KHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
27-301 1.18e-111

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 324.63  E-value: 1.18e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  27 LWISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFL 106
Cdd:cd15917   1 IWLSIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 107 HGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDM 186
Cdd:cd15917  81 HSFTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 187 IHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRF 266
Cdd:cd15917 161 VKLACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576081 267 AKHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQI 301
Cdd:cd15917 241 GHHVPPHVHILLANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
27-301 7.21e-102

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 299.98  E-value: 7.21e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  27 LWISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFL 106
Cdd:cd15221   1 VWISIPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 107 HGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDM 186
Cdd:cd15221  81 HFVFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 187 IHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRF 266
Cdd:cd15221 161 ARLACADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576081 267 AKHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQI 301
Cdd:cd15221 241 GRHIPRHVHILLANLYVLVPPMLNPIVYGVKTKQI 275
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
27-301 9.13e-101

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 296.87  E-value: 9.13e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  27 LWISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFL 106
Cdd:cd15953   1 IWISIPFCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 107 HGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDM 186
Cdd:cd15953  81 HTLSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 187 IHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRF 266
Cdd:cd15953 161 VKLACGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576081 267 AKHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQI 301
Cdd:cd15953 241 GQGIAPHIHIILANLYLLVPPMLNPIIYGVKTKEI 275
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
26-302 1.51e-100

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 296.43  E-value: 1.51e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  26 HLWISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFF 105
Cdd:cd15948   1 HPWISIPFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 106 LHGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQD 185
Cdd:cd15948  81 LHSFSIMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 186 MIHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHR 265
Cdd:cd15948 161 VVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHR 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47576081 266 FAKHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQIR 302
Cdd:cd15948 241 FARHVAPHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
27-301 2.42e-99

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 293.48  E-value: 2.42e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  27 LWISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFL 106
Cdd:cd15951   1 VWISIPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 107 HGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDM 186
Cdd:cd15951  81 HSFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 187 IHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRF 266
Cdd:cd15951 161 VKLACADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576081 267 AKHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQI 301
Cdd:cd15951 241 GHNVPPHVHILIANVYLLVPPMLNPIIYGVRTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
34-309 3.08e-98

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 290.94  E-value: 3.08e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081    34 FCL-YTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:pfam13853   1 FCLmYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081   113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVCA 192
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081   193 DIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRFAKHASP 272
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPP 240
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 47576081   273 LVHVLMANIYLLAPPVMNPIIYSAKTKQIRQGITHLL 309
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
27-301 2.70e-95

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 283.12  E-value: 2.70e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  27 LWISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFL 106
Cdd:cd15952   1 FWIGFPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 107 HGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDM 186
Cdd:cd15952  81 HTFTGMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 187 IHLVCADIRVNSWYGFaLVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRF 266
Cdd:cd15952 161 AKLACASIRINIIYGL-FAISVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRF 239
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576081 267 AKHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQI 301
Cdd:cd15952 240 GHNIPRYIHILLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
27-301 2.48e-93

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 278.14  E-value: 2.48e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  27 LWISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFL 106
Cdd:cd15950   1 FWIAIPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 107 HGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDM 186
Cdd:cd15950  81 HSFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 187 IHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRF 266
Cdd:cd15950 161 VKLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYTQRF 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576081 267 AKHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQI 301
Cdd:cd15950 241 GQGVPPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
11-302 3.63e-92

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 275.89  E-value: 3.63e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  11 PFYFILTGIPGFEAIHLWISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFN 90
Cdd:cd15949   1 PSTFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  91 IREISFEACFAQFFFLHGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPF 170
Cdd:cd15949  81 SNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 171 CHSHLLSHSYCLHQDMIHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAV 250
Cdd:cd15949 161 YRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 47576081 251 LVLYVPMVGVSMTHRFAKHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQIR 302
Cdd:cd15949 241 LAFYVPIAVSSLIHRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
28-305 3.24e-83

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 252.60  E-value: 3.24e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  28 WISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLH 107
Cdd:cd15223   2 WLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 108 GFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMI 187
Cdd:cd15223  82 FFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 188 HLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRFA 267
Cdd:cd15223 162 SLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFG 241
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47576081 268 KHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQIRQGI 305
Cdd:cd15223 242 KTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
28-301 8.66e-80

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 243.62  E-value: 8.66e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  28 WISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLH 107
Cdd:cd15956   2 WLSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 108 GFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMI 187
Cdd:cd15956  82 AFSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 188 HLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRFA 267
Cdd:cd15956 162 KLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFG 241
                       250       260       270
                ....*....|....*....|....*....|....
gi 47576081 268 KHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQI 301
Cdd:cd15956 242 HSVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
28-301 7.28e-79

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 241.21  E-value: 7.28e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  28 WISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLH 107
Cdd:cd15955   2 WIGIPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 108 GFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLK-RLPFCHSHLLSHSYCLHQDM 186
Cdd:cd15955  82 TLQAFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIKlRLHHFRSTVISHSYCEHMAV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 187 IHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRF 266
Cdd:cd15955 162 VKLAADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRF 241
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576081 267 AKHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQI 301
Cdd:cd15955 242 GHHVAPYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
27-301 7.71e-77

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 236.26  E-value: 7.71e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  27 LWISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFL 106
Cdd:cd15954   1 IWISIPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 107 HGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDM 186
Cdd:cd15954  81 HTFTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 187 IHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRF 266
Cdd:cd15954 161 VKLACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576081 267 AKH-ASPLVHVLMANIYLLAPPVMNPIIYSAKTKQI 301
Cdd:cd15954 241 GGHhITPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
27-295 4.50e-59

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 190.39  E-value: 4.50e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  27 LWISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFL 106
Cdd:cd13954   1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 107 HGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDM 186
Cdd:cd13954  81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 187 IHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMthRF 266
Cdd:cd13954 161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYV--RP 238
                       250       260
                ....*....|....*....|....*....
gi 47576081 267 AKHASPLVHVLMANIYLLAPPVMNPIIYS 295
Cdd:cd13954 239 SSSYSSDLDKVVSVFYTVVTPMLNPIIYS 267
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
33-302 8.91e-46

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 156.08  E-value: 8.91e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15225   7 FLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVigRIGLAIICrCVLAVLPSL---FLLKRLPFCHSHLLSHSYCLHQDMIHL 189
Cdd:cd15225  87 ECFLLAAMAYDRYVAICNPLRYTLIMNRRV--CLQLVAGS-WLSGILVSLgqtTLIFSLPFCGSNEINHFFCDIPPVLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 190 VCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPmvgVSMTH-RFAK 268
Cdd:cd15225 164 ACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGC---ASFTYlRPKS 240
                       250       260       270
                ....*....|....*....|....*....|....
gi 47576081 269 HASPLVHVLMANIYLLAPPVMNPIIYSAKTKQIR 302
Cdd:cd15225 241 SYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVK 274
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
27-295 1.65e-43

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 150.21  E-value: 1.65e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  27 LWISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFL 106
Cdd:cd15914   1 LLLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 107 HGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDM 186
Cdd:cd15914  81 HSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 187 IHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHiLAVLVLYVPMVGVsMTHRF 266
Cdd:cd15914 161 LSLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAH-LTVVLLFFGSVSF-MYLRL 238
                       250       260
                ....*....|....*....|....*....
gi 47576081 267 AKHASPLVHVLMANIYLLAPPVMNPIIYS 295
Cdd:cd15914 239 SKSYSLDYDRAIAVVYAVLTPFFNPIIYS 267
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
33-305 5.04e-42

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 146.60  E-value: 5.04e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15235   8 FLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNT 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVigRIGLAIICrCVLAVLPSL---FLLKRLPFCHSHLLSHSYCLHQDMIHL 189
Cdd:cd15235  88 DSFLLAVMAYDRYVAICHPLHYATVMSPKR--CLLLVAGS-WLLSHLHSLlhtLLMSRLSFCGSNEIPHFFCDLQPLLKL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 190 VCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMthRFAKH 269
Cdd:cd15235 165 SCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYF--QPSSS 242
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576081 270 ASPLVHVLMANIYLLAPPVMNPIIYSAKTKQIRQGI 305
Cdd:cd15235 243 YSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
14-302 2.99e-41

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 144.77  E-value: 2.99e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  14 FILTGIPGFEAIHLWISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIRE 93
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  94 ISFEACFAQFFFLHGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEV-IGRIGLAIICRCVLAVLPSLFLLkRLPFCH 172
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVcVSLVAGSYLAGFLNSTVHTGFIL-RLSFCG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 173 SHLLSHSYCLHQDMIHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLV 252
Cdd:cd15408 160 SNVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTL 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 47576081 253 LYvpmvgVSMTHRFAKHASPLVHVLM---ANIYLLAPPVMNPIIYSAKTKQIR 302
Cdd:cd15408 240 FY-----GSLAFMYLRPSSRYSLDLDkvaSVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
33-295 3.86e-40

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 141.47  E-value: 3.86e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15912   7 LLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIgrIGLAIICRCV--LAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLV 190
Cdd:cd15912  87 EFFLLAVMSFDRYVAICNPLHYPTIMNSRVC--LQLVLGSWVGgfLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 191 CADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYvpmvGVS--MTHRFAK 268
Cdd:cd15912 165 CSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFY----GSCifMYVRPSQ 240
                       250       260
                ....*....|....*....|....*..
gi 47576081 269 HASPLVHVLMANIYLLAPPVMNPIIYS 295
Cdd:cd15912 241 SSSLDLNKVVALLNTVVTPLLNPFIYT 267
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
29-305 1.33e-39

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 140.09  E-value: 1.33e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  29 ISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHG 108
Cdd:cd15231   3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 109 FSFMESSVLLAMSFDRYVAICRPLHYASILTSEVigRIGLAIICrCVLAVLPSL---FLLKRLPFCHSHLLSHSYCLHQD 185
Cdd:cd15231  83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKV--CLQLAAAS-WLCGFLNSAvhtVLTFRLSFCGSNQISHFFCDIPP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 186 MIHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYV--------PM 257
Cdd:cd15231 160 LLKLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGtaifnynrPS 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 47576081 258 VGVSMthrfakHASPLVHVLmaniYLLAPPVMNPIIYSAKTKQIRQGI 305
Cdd:cd15231 240 SGYSL------DKDTLISVL----YSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
33-295 3.11e-39

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 138.93  E-value: 3.11e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15232   7 FLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVCA 192
Cdd:cd15232  87 ELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 193 DIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMthRFAKHASP 272
Cdd:cd15232 167 DTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYI--RPSSSYSP 244
                       250       260
                ....*....|....*....|...
gi 47576081 273 LVHVLMANIYLLAPPVMNPIIYS 295
Cdd:cd15232 245 EKDKVVAVLYSVVTPTLNPLIYS 267
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
29-302 3.93e-39

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 138.99  E-value: 3.93e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  29 ISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHG 108
Cdd:cd15411   3 LFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 109 FSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIH 188
Cdd:cd15411  83 LATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 189 LVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMV------GVSM 262
Cdd:cd15411 163 LSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIftylrpSSSY 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 47576081 263 THRFAKHASPLvhvlmaniYLLAPPVMNPIIYSAKTKQIR 302
Cdd:cd15411 243 SLGQDKVASVF--------YTVVIPMLNPLIYSLRNKEVK 274
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
33-305 4.94e-39

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 138.60  E-value: 4.94e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15419   7 FLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEV-IGRIGLAIICRCVLAVLPSLFLLkRLPFCHSHLLSHSYCLHQDMIHLVC 191
Cdd:cd15419  87 EGFLLAAMAYDRFIAICNPLLYPVIMSRRVcVQLVAGSYLCGCINSIIQTSFTF-SLSFCGSNEIDHFFCDVPPLLKLSC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 192 ADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYvpMVGVSMTHRFAKHAS 271
Cdd:cd15419 166 SDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFY--GTVFFMYAQPGAVSS 243
                       250       260       270
                ....*....|....*....|....*....|....
gi 47576081 272 PLVHVLMANIYLLAPPVMNPIIYSAKTKQIRQGI 305
Cdd:cd15419 244 PEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEAL 277
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
33-295 3.89e-38

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 136.10  E-value: 3.89e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15230   7 FLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEV-IGRIGLAIICRCVLAVLPSLFLLkRLPFCHSHLLSHSYCLHQDMIHLVC 191
Cdd:cd15230  87 ECFLLAAMAYDRYVAICNPLLYTVIMSKRVcIQLVAGSYLCGFVNSIVHTSSTF-SLSFCGSNVINHFFCDIPPLLKLSC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 192 ADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMvgVSMTHRFAKHAS 271
Cdd:cd15230 166 SDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTL--IFMYLRPSSSYS 243
                       250       260
                ....*....|....*....|....
gi 47576081 272 PLVHVLMANIYLLAPPVMNPIIYS 295
Cdd:cd15230 244 LDQDKVVSVFYTVVIPMLNPLIYS 267
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
33-302 6.05e-37

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 133.22  E-value: 6.05e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15420   7 FSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVigRIGLAIICRC--VLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLV 190
Cdd:cd15420  87 ECVLLAVMSYDRYVAICHPLRYTVIMNWRV--CTTLAATSWAcgFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 191 CADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRFAKHA 270
Cdd:cd15420 165 CADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNSA 244
                       250       260       270
                ....*....|....*....|....*....|..
gi 47576081 271 SPLVHVLManIYLLAPPVMNPIIYSAKTKQIR 302
Cdd:cd15420 245 EQEKILSL--FYSLFNPMLNPLIYSLRNKQVK 274
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
36-294 1.20e-36

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 132.36  E-value: 1.20e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  36 LYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFMESS 115
Cdd:cd15947  10 FYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGSTECV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 116 VLLAMSFDRYVAICRPLHYASILTSEV-IGRIGLAIICRCVLAVLPSLFLLKrLPFCHSHLLSHSYCLHQDMIHLVCADI 194
Cdd:cd15947  90 LLAVMAFDRYVAVCRPLHYTVIMHPRLcVQLAALSWLSGLANSLLQTTLTLQ-LPLCGHHTLDHFFCEVPALIKLACVDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 195 RVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPmvGVSMTHRFAKHASPLV 274
Cdd:cd15947 169 TFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGT--AIYMYLQPPSSYSQDQ 246
                       250       260
                ....*....|....*....|
gi 47576081 275 HVLMANIYLLAPPVMNPIIY 294
Cdd:cd15947 247 GKFISLFYTVVTPTLNPLIY 266
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
33-295 1.24e-36

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 132.35  E-value: 1.24e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15918   7 FLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEvigRIGLAIICRCVLAVLPSL---FLLKRLPFCHSHLLSHSYCLHQDMIHL 189
Cdd:cd15918  87 DNFLLAVMAYDRYVAICHPLHYTTIMSPR---LCILLVAASWVITNLHSLlhtLLMARLSFCASNEIPHFFCDLNPLLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 190 VCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRFAKH 269
Cdd:cd15918 164 SCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHS 243
                       250       260
                ....*....|....*....|....*.
gi 47576081 270 ASPlvHVLMANIYLLAPPVMNPIIYS 295
Cdd:cd15918 244 ASK--DSVAAVMYTVVTPMLNPFIYS 267
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
33-295 1.76e-36

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 131.63  E-value: 1.76e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15237   7 FLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAI-ICRCVLAVLPSLFLLkRLPFCHSHLLSHSYCLHQDMIHLVC 191
Cdd:cd15237  87 ECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSwASGFLNSLVLTSLTL-RLPFCGPNHINHFFCEAPAVLKLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 192 ADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPmvGVSMTHRFAKHAS 271
Cdd:cd15237 166 ADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGT--AIFMYMRPHSTHS 243
                       250       260
                ....*....|....*....|....
gi 47576081 272 PLVHVLMANIYLLAPPVMNPIIYS 295
Cdd:cd15237 244 PDQDKMISVFYTIVTPMLNPLIYS 267
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
33-295 2.53e-36

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 131.27  E-value: 2.53e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15915   7 FLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVCA 192
Cdd:cd15915  87 EAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLACG 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 193 DIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFN-TATWADRLRALNNCLSHILAVLVLYVPMVGVSMthRFAKHAS 271
Cdd:cd15915 167 DTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLkVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYI--RPSSGDS 244
                       250       260
                ....*....|....*....|....
gi 47576081 272 PLVHVLMANIYLLAPPVMNPIIYS 295
Cdd:cd15915 245 LEQDRIVALLYTVVTPVLNPLIYT 268
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
33-305 3.70e-36

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 131.37  E-value: 3.70e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15412   7 FLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVIT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVCA 192
Cdd:cd15412  87 EYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 193 DIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMvgVSMTHRFAKHASP 272
Cdd:cd15412 167 DTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTL--FCMYLRPPSEESV 244
                       250       260       270
                ....*....|....*....|....*....|...
gi 47576081 273 LVHVLMANIYLLAPPVMNPIIYSAKTKQIRQGI 305
Cdd:cd15412 245 EQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQAL 277
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
14-309 1.04e-35

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 130.56  E-value: 1.04e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  14 FILTGIPGFEAIHLWISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIRE 93
Cdd:cd15943   2 FILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  94 ISFEACFAQFFFLHGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLA-IICRCVLAVLPSlFLLKRLPFCH 172
Cdd:cd15943  82 ISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGsYLIGFVNALIQT-ICTFRLPFCG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 173 SHLLSHSYCLHQDMIHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLV 252
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47576081 253 LYVPMvgVSMTHRFAKHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQIRQGITHLL 309
Cdd:cd15943 241 FYGTT--LFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
33-295 1.49e-35

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 129.50  E-value: 1.49e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFL-----------------SMlaltdlgltlttlptVMQLLwfNIREIS 95
Cdd:cd15227   7 FLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLknlsfldlcyisvtvpkSI---------------ANSLT--NTRSIS 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  96 FEACFAQFFFLHGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRI-GLAIICRCVLAVLPSLFLLkRLPFCHSH 174
Cdd:cd15227  70 FLGCVAQVFLFIFFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMaAASWLSGLLYGALHTANTF-SLPFCGSN 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 175 LLSHSYCLHQDMIHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLY 254
Cdd:cd15227 149 VIHQFFCDIPQLLKLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFL 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47576081 255 VPmvGVSMTHRFAKHASPLVHVLMANIYLLAPPVMNPIIYS 295
Cdd:cd15227 229 ST--GSFAYLKPPSDSPSLLDLLLSVFYSVVPPTLNPIIYS 267
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
33-302 3.06e-35

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 128.87  E-value: 3.06e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15229   7 FLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIicrCVLAVLPSL---FLLKRLPFCHSHLLSHSYCLHQDMIHL 189
Cdd:cd15229  87 EAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGA---WALGFLYALintLLLLNLHFCGPNEINHFSCELPSLLPL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 190 VCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPmvGVSMTHRFAKH 269
Cdd:cd15229 164 SCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGT--GFFRYLRPNSA 241
                       250       260       270
                ....*....|....*....|....*....|...
gi 47576081 270 ASPLVHVLMANIYLLAPPVMNPIIYSAKTKQIR 302
Cdd:cd15229 242 SSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVK 274
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
33-302 3.33e-35

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 128.72  E-value: 3.33e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLS-MLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSF 111
Cdd:cd15916   7 FLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGhLSFLDMWLSTVTVPKMLAGFLEPGGKVISFGGCVAQLYFFHFLGS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 112 MESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVC 191
Cdd:cd15916  87 TECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLAC 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 192 ADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMThrfaKHAS 271
Cdd:cd15916 167 ADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLR----PGSK 242
                       250       260       270
                ....*....|....*....|....*....|.
gi 47576081 272 PLVHVLMANIYLLAPPVMNPIIYSAKTKQIR 302
Cdd:cd15916 243 EALDGVIAVFYTVVTPLLNPLIYTLRNKEVK 273
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
31-295 4.90e-35

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 127.99  E-value: 4.90e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  31 IPFFCL----YTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFL 106
Cdd:cd15911   1 ILLFLLflviYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 107 HGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIgrIGLAIIC--RCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQ 184
Cdd:cd15911  81 GSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLC--LQLAAGSwiSGFLASTITVILMSQLTFCGPNEIDHFFCDFA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 185 DMIHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTH 264
Cdd:cd15911 159 PLLKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVP 238
                       250       260       270
                ....*....|....*....|....*....|.
gi 47576081 265 RfaKHASPLVHVLMANIYLLAPPVMNPIIYS 295
Cdd:cd15911 239 S--TNTSRDLNKVFSLFYTVLTPLVNPLIYS 267
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
14-303 1.01e-34

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 127.94  E-value: 1.01e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  14 FILTGIPGFEAIHLWISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIRE 93
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  94 ISFEACFAQFFFLHGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHS 173
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 174 HLLSHSYCLHQDMIHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVL 253
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 47576081 254 YVPMvgVSMTHRFAKHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQIRQ 303
Cdd:cd15945 241 YGTL--LFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKE 288
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
33-305 2.24e-34

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 126.42  E-value: 2.24e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15236   7 FLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEV-IGRIGLAIICRCVLAVLPSLfLLKRLPFCHSHLLSHSYCLHQDMIHLVC 191
Cdd:cd15236  87 DSFLLAVMAYDRYVAICHPLHYTAIMRPELcVLLVAGSWVLTCFHALLHTL-LLARLSFCADNVIPHFFCDLVALLKLSC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 192 ADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRFAKhaS 271
Cdd:cd15236 166 SSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNN--S 243
                       250       260       270
                ....*....|....*....|....*....|....
gi 47576081 272 PLVHVLMANIYLLAPPVMNPIIYSAKTKQIRQGI 305
Cdd:cd15236 244 SDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
33-294 2.98e-34

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 125.86  E-value: 2.98e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15224   7 FLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVCA 192
Cdd:cd15224  87 ECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCT 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 193 DIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMvgVSMTHRFAKHASP 272
Cdd:cd15224 167 DMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSAT--LFMYARPKAISSF 244
                       250       260
                ....*....|....*....|..
gi 47576081 273 LVHVLMANIYLLAPPVMNPIIY 294
Cdd:cd15224 245 DSNKLVSVLYTVVTPLLNPIIY 266
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
33-306 3.55e-34

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 125.98  E-value: 3.55e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15409   7 FLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIglaIICRCVLAVLPSLF---LLKRLPFCHSHLLSHSYCLHQDMIHL 189
Cdd:cd15409  87 ECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQL---ITASYIGGFLHSMIhvgLTFRLSFCGSNEINHFFCDIPPLLKI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 190 VCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRfakH 269
Cdd:cd15409 164 SCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPS---S 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47576081 270 ASPLVHVLMANI-YLLAPPVMNPIIYSAKTKQIRQGIT 306
Cdd:cd15409 241 LYALDQDMMDSLfYTIVIPLLNPFIYSLRNKEVIDALR 278
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
27-302 3.99e-34

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 125.98  E-value: 3.99e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  27 LWISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFL 106
Cdd:cd15429   1 LGLFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 107 HGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIgrIGLAIICRCV---LAVLPSLFLLkRLPFCHSHLLSHSYCLH 183
Cdd:cd15429  81 LALGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLC--IQLAAASWTSgflNSLVQTAFTF-RLPFCGHNTINHFSCEL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 184 QDMIHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMt 263
Cdd:cd15429 158 LAVVRLACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYM- 236
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47576081 264 hRFAKHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQIR 302
Cdd:cd15429 237 -RPRSGSSALQEKMISLFYAVVTPMLNPLIYSLRNKEVK 274
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
14-309 2.11e-33

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 124.31  E-value: 2.11e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  14 FILTGIPGFEAIHLWISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIRE 93
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  94 ISFEACFAQFFFLHGFSFMESSVLLAMSFDRYVAICRPLHYASILTSE-----VIGRIGLAIICRCVLavlpsLFLLKRL 168
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKlcvllVAGSYLWGIVCSLIH-----TCGLLRL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 169 PFCHSHLLSHSYCLHQDMIHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHIL 248
Cdd:cd15410 156 SFCGSNVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLT 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47576081 249 AVLVLYVPMvgVSMTHRFAKHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQIRQGITHLL 309
Cdd:cd15410 236 AITIFHGTI--LFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
31-302 3.02e-33

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 123.68  E-value: 3.02e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  31 IPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFS 110
Cdd:cd15407   5 IIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 111 FMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIglaIICRCVLAVLPSLFLLK---RLPFCHSHLLSHSYCLHQDMI 187
Cdd:cd15407  85 TVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACL---TIGCYVCGFLNASIHTGntfRLSFCKSNVINHFFCDIPPVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 188 HLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVpmVGVSMTHRFA 267
Cdd:cd15407 162 ALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYG--TVIFMYLQPS 239
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576081 268 KHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQIR 302
Cdd:cd15407 240 SSHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVK 274
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
29-305 3.13e-33

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 123.26  E-value: 3.13e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  29 ISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHG 108
Cdd:cd15434   3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 109 FSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGR-IGLAIICRCVLAVLPSLFLLkRLPFCHSHLLSHSYCLHQDMI 187
Cdd:cd15434  83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKlVAMSWLIGFGNSLVLSPLTL-SLPRCGHHRVDHFFCEMPALI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 188 HLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMvgVSMTHRFA 267
Cdd:cd15434 162 KLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTI--IYMYLQPK 239
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47576081 268 KHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQIRQGI 305
Cdd:cd15434 240 NSVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
33-303 6.23e-33

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 122.54  E-value: 6.23e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15424   7 ILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGST 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVigRIGLAIICRCVLAVLPSLFL--LKRLPFCHSHLLSHSYCLHQDMIHLV 190
Cdd:cd15424  87 ECLLLGAMAYDRYLAICHPLLYAAAMGRWR--QLQLALSCWAIGFLLSVINVgcTLRHPFCGPNHINHFFCELPVVLKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 191 CADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMvgVSMTHRFAKHA 270
Cdd:cd15424 165 CADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTV--ISMYMRPRSGS 242
                       250       260       270
                ....*....|....*....|....*....|...
gi 47576081 271 SPLVHVLMANIYLLAPPVMNPIIYSAKTKQIRQ 303
Cdd:cd15424 243 TPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHG 275
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
33-295 1.10e-32

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 121.65  E-value: 1.10e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15913   7 FSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVCA 192
Cdd:cd15913  87 ECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLALSCV 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 193 DIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHiLAVLVLYVPMVGVSMTHRFAKHaSP 272
Cdd:cd15913 167 PAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSH-LAVVSLFYGSVMVMYVSPGSGN-ST 244
                       250       260
                ....*....|....*....|...
gi 47576081 273 LVHVLMANIYLLAPPVMNPIIYS 295
Cdd:cd15913 245 GMQKIVTLFYSVVTPLLNPLIYS 267
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
33-302 3.33e-32

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 120.93  E-value: 3.33e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15416   7 FLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEV-IGRIGLAIICRCVLAVLPSLFLLkRLPFCHSHLLSHSYCLHQDMIHLVC 191
Cdd:cd15416  87 ECFLLAAMAYDRYVAICNPLLYSTIMSQKVcVLLVAASYLGGCLNALVFTTCVF-SLSFCGPNEINHFFCDFPPLLKLSC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 192 ADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLY--VPMVGVSMTHRFAKH 269
Cdd:cd15416 166 SDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYgtITFIYVMPNSSYSMD 245
                       250       260       270
                ....*....|....*....|....*....|...
gi 47576081 270 ASPLVHVLmaniYLLAPPVMNPIIYSAKTKQIR 302
Cdd:cd15416 246 QNKVVSVF----YMVVIPMLNPLIYSLRNKEVK 274
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
31-295 6.50e-32

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 119.64  E-value: 6.50e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  31 IPFFCL----YTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFL 106
Cdd:cd15431   1 IILFVLllivYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 107 HGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIgrIGLAIICR---CVLAVLPslFLLKRLPFCHSHLLSHSYCLH 183
Cdd:cd15431  81 LFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVC--IQLAAGSWvsaFLLTVIP--VLTMPLHFCGPNVINHFFCEV 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 184 QDMIHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPmvGVSMT 263
Cdd:cd15431 157 QALLKLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGT--AIFMY 234
                       250       260       270
                ....*....|....*....|....*....|..
gi 47576081 264 HRFAKHASPLVHVLMANIYLLAPPVMNPIIYS 295
Cdd:cd15431 235 LRPQSKSSSDQDKIISVFYGVVTPMLNPLIYS 266
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
33-305 6.98e-32

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 119.83  E-value: 6.98e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15415   7 FLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVCA 192
Cdd:cd15415  87 EGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 193 DIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPmVGVSMTHRFAKHASP 272
Cdd:cd15415 167 DTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGS-VSFSYIQPSSQYSLE 245
                       250       260       270
                ....*....|....*....|....*....|...
gi 47576081 273 LVHVLmANIYLLAPPVMNPIIYSAKTKQIRQGI 305
Cdd:cd15415 246 QEKVS-AVFYTLVIPMLNPLIYSLRNKDVKDAL 277
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
33-295 8.65e-32

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 119.51  E-value: 8.65e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15946   7 FLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGIT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRI-GLAIICRCVLAVLPSLFLLkRLPFCHSHLLSHSYCLHQDMIHLVC 191
Cdd:cd15946  87 ECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMvAGSWVCGVFSSLLHTFFTM-RLPYCGPNEINHYFCEVPAVLKLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 192 ADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMthRFAKHAS 271
Cdd:cd15946 166 ADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYM--RPGSNYS 243
                       250       260
                ....*....|....*....|....
gi 47576081 272 PLVHVLMANIYLLAPPVMNPIIYS 295
Cdd:cd15946 244 PERDKKISLFYNVFTALLNPVIYS 267
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
29-313 9.32e-32

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 119.84  E-value: 9.32e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  29 ISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHG 108
Cdd:cd15414   3 LFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 109 FSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIH 188
Cdd:cd15414  83 FVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 189 LVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPM--VGVSMTHRF 266
Cdd:cd15414 163 LSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLffIYVRPSSSS 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 47576081 267 AKHASPLVHVLmaniYLLAPPVMNPIIYSAKTKQIRQGITHLLFQRK 313
Cdd:cd15414 243 SLDLDKVVSVF----YTAVIPMLNPLIYSLRNKEVKDALRRTIRRKM 285
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
33-295 1.09e-31

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 119.24  E-value: 1.09e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15939   7 FLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGR-IGLAIICRCVLAVLPSLFLLkRLPFCHSHLLSHSYCLHQDMIHLVC 191
Cdd:cd15939  87 EIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLlVGVAWVGGFLHSTIQILLTL-QLPFCGPNVIDHFFCDLFPLLKLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 192 ADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIfNTATWADRLRALNNCLSHILAVLVLYVPMVGVSM----THRFA 267
Cdd:cd15939 166 TDTYVIGLLVVANSGLICLLSFLILLISYIVILYSL-RTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMrpvtTFPID 244
                       250       260
                ....*....|....*....|....*...
gi 47576081 268 KhasplvhvLMANIYLLAPPVMNPIIYS 295
Cdd:cd15939 245 K--------VVAVFYTIITPMLNPLIYT 264
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
34-299 1.31e-31

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 119.19  E-value: 1.31e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  34 FCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFME 113
Cdd:cd15421   8 LLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGAE 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 114 SSVLLAMSFDRYVAICRPLHYASILTSEVIGRIglaIICRCVLAVLPSLFL---LKRLPFCHSHLLSHSYCLHQDMIHLV 190
Cdd:cd15421  88 CLLLALMAYDRYVAICHPLRYPVLMSPRVCLLM---AAGSWLGGSLNSLIHtvyTMHFPYCGSREIHHFFCEVPALLKLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 191 CADIRV--NSWYGFALVLLIIVLdpLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMthRFAK 268
Cdd:cd15421 165 CADTSAyeTVVYVSGVLFLLIPF--SLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYM--RPGS 240
                       250       260       270
                ....*....|....*....|....*....|.
gi 47576081 269 HASPLVHVLMANIYLLAPPVMNPIIYSAKTK 299
Cdd:cd15421 241 YHSPEQDKVVSVFYTILTPMLNPLIYSLRNK 271
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
31-309 1.52e-31

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 119.39  E-value: 1.52e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  31 IPFFCL----YTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFL 106
Cdd:cd15406  10 LPLFLLflgiYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 107 HGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDM 186
Cdd:cd15406  90 CVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 187 IHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGvsMTHRF 266
Cdd:cd15406 170 LKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIF--MYLKP 247
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 47576081 267 AKHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQIRQGITHLL 309
Cdd:cd15406 248 SSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
33-305 2.45e-31

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 118.35  E-value: 2.45e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSmlaLTDLGLTLTTLPTVMQLLwFNIRE----ISFEACFAQFFFLHG 108
Cdd:cd15432   7 FLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLS---NLSLLDLCYTTSTVPQML-VNLRSpqktISYGGCVAQLFIFLG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 109 FSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIH 188
Cdd:cd15432  83 LGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 189 LVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYvpmvgVSMTHRFAK 268
Cdd:cd15432 163 LSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFY-----GTAISMYLQ 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 47576081 269 HASPLVHV---LMANIYLLAPPVMNPIIYSAKTKQIRQGI 305
Cdd:cd15432 238 PPSNSSHDrgkMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
33-302 4.53e-31

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 117.74  E-value: 4.53e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15417   7 FLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIglaIICRCVLAVLPSLF---LLKRLPFCHSHLLSHSYCLHQDMIHL 189
Cdd:cd15417  87 ECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQL---VAGAYLGGFLNSLIqtvSMFQLSFCGPNVIDHFFCDIPPLLSL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 190 VCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRfAKH 269
Cdd:cd15417 164 SCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPS-SSH 242
                       250       260       270
                ....*....|....*....|....*....|...
gi 47576081 270 ASPLVHVLmANIYLLAPPVMNPIIYSAKTKQIR 302
Cdd:cd15417 243 SQDQDKVA-SVFYTVVIPMLNPLIYSLRNKEIK 274
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
33-302 6.37e-31

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 117.20  E-value: 6.37e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15233   7 FLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVigRIGLAIICrCVLAVLPSL---FLLKRLPFCHSHLLSHSYCLHQDMIHL 189
Cdd:cd15233  87 DCFLLTAMAYDRYLAICQPLTYSVRMSWRV--QTALVGIS-CACAFTNALthtVAMSTLKFCGPNVINHFFCDLPPLFQL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 190 VCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYvpMVGVSMTHRFAKH 269
Cdd:cd15233 164 SCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFY--GTGVFSYMRLGSV 241
                       250       260       270
                ....*....|....*....|....*....|...
gi 47576081 270 ASPLVHVLMANIYLLAPPVMNPIIYSAKTKQIR 302
Cdd:cd15233 242 YSSDKDKVIGILNTVLSPMLNPLIYSLRNKDVK 274
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
33-302 7.87e-31

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 117.15  E-value: 7.87e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15942   7 FLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVCA 192
Cdd:cd15942  87 ECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 193 DIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRFAKHASP 272
Cdd:cd15942 167 DTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQDPLDG 246
                       250       260       270
                ....*....|....*....|....*....|
gi 47576081 273 LVHVLmaniYLLAPPVMNPIIYSAKTKQIR 302
Cdd:cd15942 247 VVAVF----YTTVTPLLNPVIYTLRNKEMK 272
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
33-303 4.58e-30

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 114.98  E-value: 4.58e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15234   7 FLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVCA 192
Cdd:cd15234  87 DNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 193 DIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRFAkhASP 272
Cdd:cd15234 167 DTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT--HSS 244
                       250       260       270
                ....*....|....*....|....*....|.
gi 47576081 273 LVHVLMANIYLLAPPVMNPIIYSAKTKQIRQ 303
Cdd:cd15234 245 RKTAVASVMYTVVTPMLNPFIYSLRNKDMKG 275
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
14-309 4.78e-30

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 115.27  E-value: 4.78e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  14 FILTGIPGFEAIHLWISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIRE 93
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  94 ISFEACFAQFFFLHGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHS 173
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 174 HLLSHSYCLHQDMIHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVL 253
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47576081 254 YVPMvgVSMTHRFAKHASPLVHVLMANIYLLAPPVMNPIIYSAKTKQIRQGITHLL 309
Cdd:cd15944 241 YGTV--IFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
31-302 6.31e-30

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 114.50  E-value: 6.31e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  31 IPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFS 110
Cdd:cd15428   5 ILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 111 FMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLV 190
Cdd:cd15428  85 ITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 191 CADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRfaKHA 270
Cdd:cd15428 165 STDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPK--SST 242
                       250       260       270
                ....*....|....*....|....*....|..
gi 47576081 271 SPLVHVLMANIYLLAPPVMNPIIYSAKTKQIR 302
Cdd:cd15428 243 SKEYDKMISVFYIIVTPMLNPLIYSLRNKEVK 274
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
31-302 1.77e-29

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 113.28  E-value: 1.77e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  31 IPFFCL----YTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFL 106
Cdd:cd15405   1 IPLFFLflgiYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 107 HGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDM 186
Cdd:cd15405  81 CFFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 187 IHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLY--------VPMV 258
Cdd:cd15405 161 LQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFgsgafmylKPSS 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 47576081 259 GVSMTHRfaKHASPLvhvlmaniYLLAPPVMNPIIYSAKTKQIR 302
Cdd:cd15405 241 VGSVNQG--KVSSVF--------YTNVVPMLNPLIYSLRNKDVK 274
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
36-295 1.89e-29

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 113.23  E-value: 1.89e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  36 LYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFMESS 115
Cdd:cd15430  10 MYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 116 VLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVCADIR 195
Cdd:cd15430  90 LLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVDIS 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 196 VNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMvgVSMTHRFAKHASPLVH 275
Cdd:cd15430 170 LNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTI--LFMYMKPKSKNAQISD 247
                       250       260
                ....*....|....*....|
gi 47576081 276 VLMANIYLLAPPVMNPIIYS 295
Cdd:cd15430 248 KLITLFYGVVTPMLNPIIYS 267
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
33-302 3.85e-29

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 112.52  E-value: 3.85e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15228   7 FLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGST 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGL-AIICRCVLAVLPSlFLLKRLPFCHSHLLSHSYCLHQDMIHLVC 191
Cdd:cd15228  87 ECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAgTWITSSFHATILT-SLTFTLPYCGSNVVDYFFCDIFPVLKLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 192 ADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRFAKHAS 271
Cdd:cd15228 166 ADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSPVLV 245
                       250       260       270
                ....*....|....*....|....*....|.
gi 47576081 272 PLVHVLMAniylLAPPVMNPIIYSAKTKQIR 302
Cdd:cd15228 246 TPVQIFNN----VVTPMLNPLIYTLRNKEVK 272
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
33-295 8.46e-29

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 111.38  E-value: 8.46e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15940   7 FLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVCA 192
Cdd:cd15940  87 EIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACT 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 193 DIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATwADRLRALNNCLSHILAVLVLYVPMVGVSMTHRFAKHASP 272
Cdd:cd15940 167 DTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRST-EGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFSEDK 245
                       250       260
                ....*....|....*....|...
gi 47576081 273 LVHVLmaniYLLAPPVMNPIIYS 295
Cdd:cd15940 246 VVSVF----YTVVTPLLNPIIYT 264
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
33-302 1.52e-28

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 110.87  E-value: 1.52e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15413   7 FLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIIS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVCA 192
Cdd:cd15413  87 ELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 193 DIRVNSwygfaLVLLII----VLDPLLIVL-SYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSM----T 263
Cdd:cd15413 167 DTHEKE-----LIILIFagfnLISSLLIVLvSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLqpksS 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 47576081 264 HRFAKHAsplvhvlMANI-YLLAPPVMNPIIYSAKTKQIR 302
Cdd:cd15413 242 HSLDTDK-------MASVfYTLVIPMLNPLIYSLRNKEVK 274
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
33-295 2.15e-28

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 110.37  E-value: 2.15e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15226   7 FSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVCA 192
Cdd:cd15226  87 EMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLACT 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 193 DIrvnswygFALVLLII-------VLDPLLIVLSYALILKSIFNTATwADRLRALNNCLSHILAVLVLYVPMVGVSMThr 265
Cdd:cd15226 167 DT-------YVLELMVVansglisLVCFLLLLISYIVILVTVRKHSS-GGSSKALSTCSAHITVVVLFFGPCIFIYVW-- 236
                       250       260       270
                ....*....|....*....|....*....|
gi 47576081 266 faKHASPLVHVLMANIYLLAPPVMNPIIYS 295
Cdd:cd15226 237 --PFSTFPVDKFLAVFYTVITPLLNPIIYT 264
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
33-297 2.66e-28

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 109.96  E-value: 2.66e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15938   7 FLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVCA 192
Cdd:cd15938  87 EMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACT 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 193 DIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTatwADRLRALNNCLSHILAVLVLYVPMVGVsmthrFAKHASP 272
Cdd:cd15938 167 DTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTIRST---EGRRKALSTCASHLMVVTLFFGPCIFI-----YARPFST 238
                       250       260
                ....*....|....*....|....*.
gi 47576081 273 L-VHVLMANIYLLAPPVMNPIIYSAK 297
Cdd:cd15938 239 FpVDKHVSVLYNVITPMLNPLIYTLR 264
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
33-303 3.53e-28

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 110.26  E-value: 3.53e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15418   8 FLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVCA 192
Cdd:cd15418  88 ECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACD 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 193 DIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMvgVSMTHRFAKHASP 272
Cdd:cd15418 168 DTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSI--LFIYSRPSSSHTP 245
                       250       260       270
                ....*....|....*....|....*....|.
gi 47576081 273 LVHVLMANIYLLAPPVMNPIIYSAKTKQIRQ 303
Cdd:cd15418 246 DRDKVVALFYTVVNPLLNPLIYSLRNKDVKE 276
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
33-295 5.04e-28

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 109.35  E-value: 5.04e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15936   7 FLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVCA 192
Cdd:cd15936  87 EVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACT 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 193 DIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRlRALNNCLSHILAVLVLYVPMVGVsMTHRFAKH-AS 271
Cdd:cd15936 167 DTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKR-KALSTCASQITVVTLIFVPCIYI-YARPFQTFpMD 244
                       250       260
                ....*....|....*....|....
gi 47576081 272 PLVHVLmaniYLLAPPVMNPIIYS 295
Cdd:cd15936 245 KAVSVL----YTVITPMLNPMIYT 264
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
33-305 8.47e-28

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 109.17  E-value: 8.47e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQ-PMYLFLSMLALTDLGLTLTTLPTVMQ-LLWFNIREISFEACFAQFFFLHGFS 110
Cdd:cd15941   7 FLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAgLLTLSGRTISFEGCVVQLYAFHFLA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 111 FMESSVLLAMSFDRYVAICRPLHYASILTSEV-IGRIGLAIICRCVLAVLPSLfLLKRLPFCHSHLLSHSYCLHQDMIHL 189
Cdd:cd15941  87 STECFLYTVMAYDRYLAICHPLHYPTAMNRRMcAGLAGGTWATGATHAAIHTS-LTFRLPYCGPCQIAYFFCDIPPVLKL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 190 VCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHRFAKH 269
Cdd:cd15941 166 ACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSSSQA 245
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576081 270 ASPLVHVLmaniYLLAPPVMNPIIYSAKTKQIRQGI 305
Cdd:cd15941 246 GAGAPAVF----YTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
27-295 1.78e-27

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 107.93  E-value: 1.78e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  27 LWISIPFFCLYTISIMGNTTILTVIRTEPSLHQ-PMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFF 105
Cdd:cd15935   1 LLLFVLVLACYAAILLGNLLIVVTVHADPHLLQsPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 106 LHGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQD 185
Cdd:cd15935  81 LHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 186 MIHLVCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIfNTATWADRLRALNNCLSHILAVLVLYVPMVGVSMTHR 265
Cdd:cd15935 161 VIKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTL-RGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPF 239
                       250       260       270
                ....*....|....*....|....*....|
gi 47576081 266 FAKHASPLVHVLmaniYLLAPPVMNPIIYS 295
Cdd:cd15935 240 SSSSVDKVASVF----YTLITPALNPLIYT 265
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
33-295 1.91e-25

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 102.51  E-value: 1.91e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  33 FFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFM 112
Cdd:cd15937   7 FLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 113 ESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVCA 192
Cdd:cd15937  87 EMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIKLACT 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 193 DIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRlRALNNCLSHILAVLVLYVPMVGVSMTHRFAKHASP 272
Cdd:cd15937 167 NTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKS-KAASTCITHIIIVFVMFGPAIYIYARPFRSFPMDK 245
                       250       260
                ....*....|....*....|...
gi 47576081 273 LVHVLMANIYllapPVMNPIIYS 295
Cdd:cd15937 246 VVAVFHTVIF----PLLNPMIYT 264
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
34-302 2.68e-24

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 99.48  E-value: 2.68e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  34 FCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSmlaLTDLGLTLTTLPTVMQLLWfNIR----EISFEACFAQFFFLHGF 109
Cdd:cd15433   8 LIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLC---HLSFVDLCFTTSTVPQLLA-NLRgpalTITRGGCVAQLFISLAL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 110 SFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHL 189
Cdd:cd15433  84 GSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 190 VCADIRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGVSM--THRFA 267
Cdd:cd15433 164 ACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLqpIHRYS 243
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576081 268 KHASPLVhvlmANIYLLAPPVMNPIIYSAKTKQIR 302
Cdd:cd15433 244 QAHGKFV----SLFYTVMTPALNPLIYTLRNKDVK 274
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
43-294 1.30e-09

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 57.69  E-value: 1.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081    43 GNTTILTVIRTEPSLHQPMYLFLSMLALT-DLGLTLTTLPTVMQLLWFNIREISFEACFAQFFFLHGFSFMESSVLLAMS 121
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVAdLLFSLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081   122 FDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHllsHSYCLHQDMIHLVCadirvNSWYG 201
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSK-----PVSYT 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081   202 FALVLLIIVLDPLLIVLSYALILKSIFNTA-------TWADRLRALNNCLSHILAVLVLYVP--MVGVSMTHRFAKHASP 272
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSAskqksseRTQRRRKALKTLAVVVVVFILCWLPyhIVNLLDSLALDCELSR 232
                         250       260
                  ....*....|....*....|....
gi 47576081   273 LVHVLMANIYLLAP--PVMNPIIY 294
Cdd:pfam00001 233 LLDKALSVTLWLAYvnSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
29-297 4.13e-09

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 56.53  E-value: 4.13e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  29 ISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFL-SMLALTDLGLTLTTLPTVMQLLWFNIREISFeACFAQFFFLH 107
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFIlNLAVADLLVGLLVIPFSLVSLLLGRWWFGDA-LCKLLGFLQS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 108 GFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMI 187
Cdd:cd00637  80 VSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 188 hlvcadirvnsWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATW--------------ADRLRALNNCLSHILAVLVL 253
Cdd:cd00637 160 -----------AYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRirssssnssrrrrrRRERKVTKTLLIVVVVFLLC 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 47576081 254 YVPMVGVSMTHRFAKHASPLVHVLMANIYLLA--PPVMNPIIYSAK 297
Cdd:cd00637 229 WLPYFILLLLDVFGPDPSPLPRILYFLALLLAylNSAINPIIYAFF 274
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
88-225 2.45e-06

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 48.40  E-value: 2.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  88 WFNIREISFEACFAQFFFLHGFSFMESSVLL--AMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLL 165
Cdd:cd14978  64 YSSSFLSYFYAYFLPYIYPLANTFQTASVWLtvALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEY 143
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 166 KRLPFCHSHLLSHSYCLHQDMIHLVCADIRVNSWYGFALVLLIIVLdpLLIVLSYALILK 225
Cdd:cd14978 144 EVVECENCNNNSYYYVIPTLLRQNETYLLKYYFWLYAIFVVLLPFI--LLLILNILLIRA 201
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
117-305 2.68e-05

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 44.90  E-value: 2.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 117 LLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSyclhqdmiHLVCADI-- 194
Cdd:cd14993  91 LVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEPGTIT--------IYICTEDwp 162
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 195 --RVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTATWADRLRALNNCLSHI-----------LAVLVLYV----PM 257
Cdd:cd14993 163 spELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRRIlrskkkvarmlIVVVVLFAlswlPY 242
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 47576081 258 VGVSMTHRFAKHASPLVHVLMANIYLLA------PPVMNPIIYSAKTKQIRQGI 305
Cdd:cd14993 243 YVLSILLDFGPLSSEESDENFLLILPFAqllgysNSAINPIIYCFMSKKFRRGF 296
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
29-304 3.21e-05

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 44.65  E-value: 3.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  29 ISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFLSMLALTDLGLTLTTLPTVMQLLWfNIREISFE--ACFAQFFFL 106
Cdd:cd14979   3 VTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFW-WQYPWAFGdgGCKLYYFLF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 107 HGFSFMESSVLLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRLPF---CHSHLLSHSYCLH 183
Cdd:cd14979  82 EACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQYLngpLPGPVPDSAVCTL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 184 QDMIHLVCADIRVNSWYGFALVLLIIVLDPLLI---VLSYALILKSIFNTATWADRLRALNNCLSHILAVLVLYVPMVGV 260
Cdd:cd14979 162 VVDRSTFKYVFQVSTFIFFVLPMFVISILYFRIgvkLRSMRNIKKGTRAQGTRNVELSLSQQARRQVVKMLGAVVIAFFV 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47576081 261 ---------------SMTHRFAKHASPLVHVLmANIYLLAPPVMNPIIYSAKTKQIRQG 304
Cdd:cd14979 242 cwlpfhaqrlmfsyaSKEDTFLFDFYQYLYPI-SGILFYLSSAINPILYNLMSSRFRVA 299
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
105-303 2.23e-03

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 39.17  E-value: 2.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 105 FLHGFSF---MESSVLL--AMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFLLKRlpfcHSHLLSHS 179
Cdd:cd14982  74 RLTGLLFyinMYGSILFltCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRST----IAKENNST 149
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 180 YCLHQDMIHLvcadiRVNSWYGFALVLLIIVLDPLLIVLSYALILKSIFNTAT----WADRLRALNNCLSHILAVLVLYV 255
Cdd:cd14982 150 TCFEFLSEWL-----ASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKqsqkSVRKRKALRMILIVLAVFLVCFL 224
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47576081 256 P-----MVGVSMTHRFAKHASPLVHVLMANIYLL----APPVMNPIIYSAKTKQIRQ 303
Cdd:cd14982 225 PyhvtrILYLLVRLSFIADCSARNSLYKAYRITLclasLNSCLDPLIYYFLSKTFRK 281
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
100-302 2.89e-03

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 38.92  E-value: 2.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 100 FAQFFFLHGFSFMessvLLAMSFDRYVAICRPLhyaSILTSEVIGRIGLAIICRC-VLAVLPSLFLLkrlpfchsHLLSH 178
Cdd:cd15195  78 FLKQFGMYLSSFM----LVVIALDRVFAILSPL---SANQARKRVKIMLTVAWVLsALCSIPQSFIF--------SVLRK 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081 179 SYclhqDMIHLV-CADIRVNSW------YGFALVLLIIVLDPLLIVLSYALILKSIFNTATWAD---------------- 235
Cdd:cd15195 143 MP----EQPGFHqCVDFGSAPTkkqerlYYFFTMILSFVIPLIITVTCYLLILFEISKMAKRARdtpisnrrrsrtnsle 218
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47576081 236 --RLRALNNCLSHILAVLVLYVPMVGVSMTHRFAKHA-----SPLVHVLMANIYLlaPPVMNPIIYSAKTKQIR 302
Cdd:cd15195 219 raRMRTLRMTALIVLTFIVCWGPYYVLGLWYWFDKESiknlpPALSHIMFLLGYL--NPCLHPIIYGVFMKEIR 290
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
117-163 6.23e-03

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 37.85  E-value: 6.23e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 47576081 117 LLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRcVLAVLPSLF 163
Cdd:cd15135  96 VATLSFERYIAICHPFKYKALSGSRVRLLICFVWLTS-ALVALPLLF 141
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
28-160 7.61e-03

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 37.16  E-value: 7.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576081  28 WISIPFFCLYTISIMGNTTILTVIRTEPSLHQPMYLFL-SMLALTDLGLTLTTLPTVMQLLwFNIREISFEACfaQFFFL 106
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIvSLAVADLLVALLVMPFSAVYTL-LGYWPFGPVLC--RFWIA 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47576081 107 HGFSFMESSV--LLAMSFDRYVAICRPLHYASILTSE-VIGRIGLAIICRCVLAVLP 160
Cdd:cd14967  78 LDVLCCTASIlnLCAISLDRYLAITRPLRYRQLMTKKrALIMIAAVWVYSLLISLPP 134
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
111-164 8.68e-03

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 37.27  E-value: 8.68e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47576081 111 FMESSV-------LLAMSFDRYVAICRPLHYASILTSEVIGRIGLAIICRCVLAVLPSLFL 164
Cdd:cd14997  79 FVELTVahasvltILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFI 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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