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Conserved domains on  [gi|47575941|ref|NP_001000165|]
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olfactory receptor Olr148 [Rattus norvegicus]

Protein Classification

family 52 olfactory receptor( domain architecture ID 11607001)

family 52 olfactory receptor is a G-protein coupled receptor (GPCR) that plays a central role in olfaction, the sense of smell; GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins by binding to an extracellular agonist, which induces conformational changes that lead to the activation of heterotrimeric G proteins, which then bind to and activate numerous downstream effector proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
33-308 5.61e-168

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320349  Cd Length: 275  Bit Score: 467.54  E-value: 5.61e-168
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  33 LWIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCV 112
Cdd:cd15221   1 VWISIPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 113 HSIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGI 192
Cdd:cd15221  81 HFVFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 193 ARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRF 272
Cdd:cd15221 161 ARLACADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47575941 273 GHNrVPKNVHIFLANLYVLVPPVLNPIIYGARTKEI 308
Cdd:cd15221 241 GRH-IPRHVHILLANLYVLVPPMLNPIVYGVKTKQI 275
 
Name Accession Description Interval E-value
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
33-308 5.61e-168

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 467.54  E-value: 5.61e-168
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  33 LWIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCV 112
Cdd:cd15221   1 VWISIPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 113 HSIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGI 192
Cdd:cd15221  81 HFVFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 193 ARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRF 272
Cdd:cd15221 161 ARLACADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47575941 273 GHNrVPKNVHIFLANLYVLVPPVLNPIIYGARTKEI 308
Cdd:cd15221 241 GRH-IPRHVHILLANLYVLVPPMLNPIVYGVKTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
39-316 8.63e-104

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 305.19  E-value: 8.63e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941    39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941   119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941   199 NITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNrVP 278
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHN-VP 239
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 47575941   279 KNVHIFLANLYVLVPPVLNPIIYGARTKEIRSRLVKLF 316
Cdd:pfam13853 240 PLLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
 
Name Accession Description Interval E-value
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
33-308 5.61e-168

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 467.54  E-value: 5.61e-168
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  33 LWIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCV 112
Cdd:cd15221   1 VWISIPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 113 HSIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGI 192
Cdd:cd15221  81 HFVFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 193 ARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRF 272
Cdd:cd15221 161 ARLACADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47575941 273 GHNrVPKNVHIFLANLYVLVPPVLNPIIYGARTKEI 308
Cdd:cd15221 241 GRH-IPRHVHILLANLYVLVPPMLNPIVYGVKTKQI 275
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
33-308 5.20e-151

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 424.78  E-value: 5.20e-151
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  33 LWIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCV 112
Cdd:cd15917   1 IWLSIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 113 HSIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGI 192
Cdd:cd15917  81 HSFTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 193 ARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRF 272
Cdd:cd15917 161 VKLACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47575941 273 GHNrVPKNVHIFLANLYVLVPPVLNPIIYGARTKEI 308
Cdd:cd15917 241 GHH-VPPHVHILLANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
33-308 6.14e-139

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 394.32  E-value: 6.14e-139
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  33 LWIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCV 112
Cdd:cd15953   1 IWISIPFCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 113 HSIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGI 192
Cdd:cd15953  81 HTLSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 193 ARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRF 272
Cdd:cd15953 161 VKLACGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47575941 273 GHNrVPKNVHIFLANLYVLVPPVLNPIIYGARTKEI 308
Cdd:cd15953 241 GQG-IAPHIHIILANLYLLVPPMLNPIIYGVKTKEI 275
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
33-308 1.40e-138

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 393.28  E-value: 1.40e-138
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  33 LWIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCV 112
Cdd:cd15952   1 FWIGFPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 113 HSIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGI 192
Cdd:cd15952  81 HTFTGMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 193 ARLACANITVNIVYGLTVALLaMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRF 272
Cdd:cd15952 161 AKLACASIRINIIYGLFAISV-LVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRF 239
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47575941 273 GHNrVPKNVHIFLANLYVLVPPVLNPIIYGARTKEI 308
Cdd:cd15952 240 GHN-IPRYIHILLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
33-308 3.85e-136

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 387.09  E-value: 3.85e-136
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  33 LWIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCV 112
Cdd:cd15951   1 VWISIPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 113 HSIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGI 192
Cdd:cd15951  81 HSFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 193 ARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRF 272
Cdd:cd15951 161 VKLACADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47575941 273 GHNrVPKNVHIFLANLYVLVPPVLNPIIYGARTKEI 308
Cdd:cd15951 241 GHN-VPPHVHILIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
34-308 1.34e-132

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 378.00  E-value: 1.34e-132
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  34 WIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVH 113
Cdd:cd15222   2 WISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 114 SIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIA 193
Cdd:cd15222  82 TFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVM 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 194 RLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFG 273
Cdd:cd15222 162 KLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFG 241
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47575941 274 HNrVPKNVHIFLANLYVLVPPVLNPIIYGARTKEI 308
Cdd:cd15222 242 KH-ASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
33-308 3.39e-125

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 359.42  E-value: 3.39e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  33 LWIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCV 112
Cdd:cd15950   1 FWIAIPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 113 HSIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGI 192
Cdd:cd15950  81 HSFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 193 ARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRF 272
Cdd:cd15950 161 VKLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYTQRF 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47575941 273 GHNrVPKNVHIFLANLYVLVPPVLNPIIYGARTKEI 308
Cdd:cd15950 241 GQG-VPPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
34-312 2.83e-111

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 324.25  E-value: 2.83e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  34 WIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVH 113
Cdd:cd15223   2 WLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 114 SIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIA 193
Cdd:cd15223  82 FFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 194 RLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFG 273
Cdd:cd15223 162 SLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFG 241
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47575941 274 hNRVPKNVHIFLANLYVLVPPVLNPIIYGARTKEIRSRL 312
Cdd:cd15223 242 -KTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
32-309 4.39e-111

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 323.78  E-value: 4.39e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  32 HLWIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFC 111
Cdd:cd15948   1 HPWISIPFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 112 VHSIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMG 191
Cdd:cd15948  81 LHSFSIMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 192 IARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHR 271
Cdd:cd15948 161 VVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHR 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47575941 272 FGHNRVPkNVHIFLANLYVLVPPVLNPIIYGARTKEIR 309
Cdd:cd15948 241 FARHVAP-HVHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
17-309 1.07e-110

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 323.27  E-value: 1.07e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  17 PVTLFLTGIPGLEFAHLWIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLN 96
Cdd:cd15949   1 PSTFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  97 ANEISFGGCLAQMFCVHSIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPY 176
Cdd:cd15949  81 SNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 177 CSHRVMAHTYCEHMGIARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVI 256
Cdd:cd15949 161 YRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 47575941 257 LVFYIPAFFSFLTHRFGHNrVPKNVHIFLANLYVLVPPVLNPIIYGARTKEIR 309
Cdd:cd15949 241 LAFYVPIAVSSLIHRFGQN-VPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
33-308 7.66e-105

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 307.91  E-value: 7.66e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  33 LWIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCV 112
Cdd:cd15954   1 IWISIPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 113 HSIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGI 192
Cdd:cd15954  81 HTFTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 193 ARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRF 272
Cdd:cd15954 161 VKLACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47575941 273 GHNRVPKNVHIFLANLYVLVPPVLNPIIYGARTKEI 308
Cdd:cd15954 241 GGHHITPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
34-308 3.21e-104

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 306.02  E-value: 3.21e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  34 WIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVH 113
Cdd:cd15956   2 WLSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 114 SIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIA 193
Cdd:cd15956  82 AFSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 194 RLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFG 273
Cdd:cd15956 162 KLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFG 241
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47575941 274 HNrVPKNVHIFLANLYVLVPPVLNPIIYGARTKEI 308
Cdd:cd15956 242 HS-VPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
39-316 8.63e-104

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 305.19  E-value: 8.63e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941    39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941   119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941   199 NITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNrVP 278
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHN-VP 239
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 47575941   279 KNVHIFLANLYVLVPPVLNPIIYGARTKEIRSRLVKLF 316
Cdd:pfam13853 240 PLLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
34-308 2.80e-100

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 296.29  E-value: 2.80e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  34 WIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVH 113
Cdd:cd15955   2 WIGIPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 114 SIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLL-RRLPYCSHRVMAHTYCEHMGI 192
Cdd:cd15955  82 TLQAFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIkLRLHHFRSTVISHSYCEHMAV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 193 ARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRF 272
Cdd:cd15955 162 VKLAADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRF 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47575941 273 GHNRVPkNVHIFLANLYVLVPPVLNPIIYGARTKEI 308
Cdd:cd15955 242 GHHVAP-YVHILLSNLYLLVPPVLNPIVYGVKTKQI 276
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
33-301 1.15e-85

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 258.57  E-value: 1.15e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  33 LWIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCV 112
Cdd:cd13954   1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 113 HSIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGI 192
Cdd:cd13954  81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 193 ARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRF 272
Cdd:cd13954 161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240
                       250       260
                ....*....|....*....|....*....
gi 47575941 273 GHnrvPKNVHIFLANLYVLVPPVLNPIIY 301
Cdd:cd13954 241 SY---SSDLDKVVSVFYTVVTPMLNPIIY 266
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
39-309 3.02e-73

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 227.34  E-value: 3.02e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15225   7 FLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQII----FAGIVRSVAIVSpFIFllrRLPYCSHRVMAHTYCEHMGIAR 194
Cdd:cd15225  87 ECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVagswLSGILVSLGQTT-LIF---SLPFCGSNEINHFFCDIPPVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 LACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGH 274
Cdd:cd15225 163 LACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSY 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47575941 275 NRvpkNVHIFLANLYVLVPPVLNPIIYGARTKEIR 309
Cdd:cd15225 243 SP---ETDKLLSLFYTVVTPMLNPIIYSLRNKEVK 274
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
41-308 9.84e-70

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 218.19  E-value: 9.84e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  41 VMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYALES 120
Cdd:cd15421   9 LIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGAEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 121 SVLLAMAFDRYVAICNPLRYTTILNHTVIAQII----FAGIVRSVaIVSPFIFllrRLPYCSHRVMAHTYCEHMGIARLA 196
Cdd:cd15421  89 LLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAagswLGGSLNSL-IHTVYTM---HFPYCGSREIHHFFCEVPALLKLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 197 CANITV--NIVYGLTVALLAmgLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGH 274
Cdd:cd15421 165 CADTSAyeTVVYVSGVLFLL--IPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYH 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47575941 275 N-RVPKNVHIFlanlYVLVPPVLNPIIYGARTKEI 308
Cdd:cd15421 243 SpEQDKVVSVF----YTILTPMLNPLIYSLRNKEV 273
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
39-304 1.55e-68

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 214.79  E-value: 1.55e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15918   7 FLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15918  87 DNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHnrvP 278
Cdd:cd15918 167 DTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSH---S 243
                       250       260
                ....*....|....*....|....*.
gi 47575941 279 KNVHIFLANLYVLVPPVLNPIIYGAR 304
Cdd:cd15918 244 ASKDSVAAVMYTVVTPMLNPFIYSLR 269
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
39-312 2.88e-65

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 206.69  E-value: 2.88e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15235   8 FLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNT 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15235  88 DSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCS 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNRVP 278
Cdd:cd15235 168 DTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSSYSADK 247
                       250       260       270
                ....*....|....*....|....*....|....
gi 47575941 279 KNVhifLANLYVLVPPVLNPIIYGARTKEIRSRL 312
Cdd:cd15235 248 DRV---ATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
39-304 2.24e-64

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 204.28  E-value: 2.24e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15230   7 FLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQII----FAGIVRSVAIVSpFIFllrRLPYCSHRVMAHTYCEHMGIAR 194
Cdd:cd15230  87 ECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVagsyLCGFVNSIVHTS-STF---SLSFCGSNVINHFFCDIPPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 LACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFL----TH 270
Cdd:cd15230 163 LSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLrpssSY 242
                       250       260       270
                ....*....|....*....|....*....|....
gi 47575941 271 RFGHNRVpknVHIFlanlYVLVPPVLNPIIYGAR 304
Cdd:cd15230 243 SLDQDKV---VSVF----YTVVIPMLNPLIYSLR 269
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
41-304 1.04e-62

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 200.16  E-value: 1.04e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  41 VMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYALES 120
Cdd:cd15947   9 IFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGSTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 121 SVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFA----GIVRSVaIVSPFIFllrRLPYCSHRVMAHTYCEHMGIARLA 196
Cdd:cd15947  89 VLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALswlsGLANSL-LQTTLTL---QLPLCGHHTLDHFFCEVPALIKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 197 CANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRfghNR 276
Cdd:cd15947 165 CVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPP---SS 241
                       250       260
                ....*....|....*....|....*...
gi 47575941 277 VPKNVHIFLANLYVLVPPVLNPIIYGAR 304
Cdd:cd15947 242 YSQDQGKFISLFYTVVTPTLNPLIYTLR 269
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
39-314 2.14e-62

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 199.46  E-value: 2.14e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15419   7 FLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQII----FAGIVRSVaIVSPFIFllrRLPYCSHRVMAHTYCEHMGIAR 194
Cdd:cd15419  87 EGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVagsyLCGCINSI-IQTSFTF---SLSFCGSNEIDHFFCDVPPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 LACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGH 274
Cdd:cd15419 163 LSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAVS 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47575941 275 NRVP-KNVHIFlanlYVLVPPVLNPIIYGARTKEIRSRLVK 314
Cdd:cd15419 243 SPEQsKVVSVF----YTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
39-309 3.56e-61

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 196.77  E-value: 3.56e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15408  20 FLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKVISFTGCLTQLYFYAVFATT 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQII----FAGIVRSvAIVSPFIFllrRLPYCSHRVMAHTYCEHMGIAR 194
Cdd:cd15408 100 ECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVagsyLAGFLNS-TVHTGFIL---RLSFCGSNVINHFFCDGPPLLA 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 LACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGH 274
Cdd:cd15408 176 LSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLFYGSLAFMYLRPSSRY 255
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47575941 275 N-RVPKNVHIFlanlYVLVPPVLNPIIYGARTKEIR 309
Cdd:cd15408 256 SlDLDKVASVF----YTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
39-304 7.45e-61

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 195.19  E-value: 7.45e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15237   7 FLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQII----FAGIVRSVAIVSpfifLLRRLPYCSHRVMAHTYCEHMGIAR 194
Cdd:cd15237  87 ECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAatswASGFLNSLVLTS----LTLRLPFCGPNHINHFFCEAPAVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 LACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGH 274
Cdd:cd15237 163 LACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTH 242
                       250       260       270
                ....*....|....*....|....*....|.
gi 47575941 275 NRV-PKNVHIFlanlYVLVPPVLNPIIYGAR 304
Cdd:cd15237 243 SPDqDKMISVF----YTIVTPMLNPLIYSLR 269
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
36-304 7.72e-61

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 194.98  E-value: 7.72e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  36 AIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSI 115
Cdd:cd15227   4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 116 YALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQI-----IFAGIVRSVAIVSPFifllrRLPYCSHRVMAHTYCEHM 190
Cdd:cd15227  84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMaaaswLSGLLYGALHTANTF-----SLPFCGSNVIHQFFCDIP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 191 GIARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTH 270
Cdd:cd15227 159 QLLKLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKP 238
                       250       260       270
                ....*....|....*....|....*....|....
gi 47575941 271 RFghnRVPKNVHIFLANLYVLVPPVLNPIIYGAR 304
Cdd:cd15227 239 PS---DSPSLLDLLLSVFYSVVPPTLNPIIYSLR 269
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
39-312 7.91e-61

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 195.49  E-value: 7.91e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15234   7 FLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15234  87 DNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNrvP 278
Cdd:cd15234 167 DTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTHS--S 244
                       250       260       270
                ....*....|....*....|....*....|....
gi 47575941 279 KNVhIFLANLYVLVPPVLNPIIYGARTKEIRSRL 312
Cdd:cd15234 245 RKT-AVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
39-304 1.22e-60

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 194.75  E-value: 1.22e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15431   7 LLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGIT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIfAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15431  87 ECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLA-AGSWVSAFLLTVIPVLTMPLHFCGPNVINHFFCEVQALLKLACS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNR-V 277
Cdd:cd15431 166 DTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKSSSdQ 245
                       250       260
                ....*....|....*....|....*..
gi 47575941 278 PKNVHIFlanlYVLVPPVLNPIIYGAR 304
Cdd:cd15431 246 DKIISVF----YGVVTPMLNPLIYSLR 268
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
39-309 1.82e-60

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 194.41  E-value: 1.82e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15231   7 FLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFA----GIVRSVAivspFIFLLRRLPYCSHRVMAHTYCEHMGIAR 194
Cdd:cd15231  87 ECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAAswlcGFLNSAV----HTVLTFRLSFCGSNQISHFFCDIPPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 LACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGH 274
Cdd:cd15231 163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGY 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47575941 275 nrvPKNVHIFLANLYVLVPPVLNPIIYGARTKEIR 309
Cdd:cd15231 243 ---SLDKDTLISVLYSIVTPMLNPIIYSLRNKEVK 274
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
41-304 7.80e-60

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 192.59  E-value: 7.80e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  41 VMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYALES 120
Cdd:cd15430   9 IMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 121 SVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACANI 200
Cdd:cd15430  89 VLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVDI 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 201 TVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRfghnrvPKN 280
Cdd:cd15430 169 SLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPK------SKN 242
                       250       260
                ....*....|....*....|....*..
gi 47575941 281 VHI---FLANLYVLVPPVLNPIIYGAR 304
Cdd:cd15430 243 AQIsdkLITLFYGVVTPMLNPIIYSLR 269
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
39-312 9.07e-60

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 192.54  E-value: 9.07e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15420   7 FSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15420  87 ECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLACA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNRVP 278
Cdd:cd15420 167 DTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNSAEQ 246
                       250       260       270
                ....*....|....*....|....*....|....
gi 47575941 279 KNVhifLANLYVLVPPVLNPIIYGARTKEIRSRL 312
Cdd:cd15420 247 EKI---LSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
39-314 6.79e-59

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 190.55  E-value: 6.79e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15417   7 FLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQII----FAGIVRSVAIVSPFIfllrRLPYCSHRVMAHTYCEHMGIAR 194
Cdd:cd15417  87 ECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVagayLGGFLNSLIQTVSMF----QLSFCGPNVIDHFFCDIPPLLS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 LACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGH 274
Cdd:cd15417 163 LSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSH 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 47575941 275 NRvpkNVHIFLANLYVLVPPVLNPIIYGARTKEIRSRLVK 314
Cdd:cd15417 243 SQ---DQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
39-316 7.09e-59

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 191.04  E-value: 7.09e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15943  21 FLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKTISFTGCAAQMYFFVAFATT 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15943 101 ECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGSNVINHFFCDVPPLLKLSCS 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFL----THRFGH 274
Cdd:cd15943 181 DTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIFYGTTLFMYLrpssSYSLDQ 260
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 47575941 275 NRVpknVHIFlanlYVLVPPVLNPIIYGARTKEIRSRLVKLF 316
Cdd:cd15943 261 DKV---VSVF----YTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
39-304 8.38e-59

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 190.16  E-value: 8.38e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVhsIYAL 118
Cdd:cd15232   7 FLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF--TWSL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLL--AMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLA 196
Cdd:cd15232  85 GSELLLltAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 197 CANITVN-IVYGLTVALLAMGlDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLthRFGHN 275
Cdd:cd15232 165 CSDTSLNeIMAFVADVFFGVG-NFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYI--RPSSS 241
                       250       260
                ....*....|....*....|....*....
gi 47575941 276 RVPKNVHIfLANLYVLVPPVLNPIIYGAR 304
Cdd:cd15232 242 YSPEKDKV-VAVLYSVVTPTLNPLIYSLR 269
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
39-314 9.59e-59

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 190.22  E-value: 9.59e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15411   7 FLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTV----IAQIIFAGIVRSVAIVSpfifLLRRLPYCSHRVMAHTYCEHMGIAR 194
Cdd:cd15411  87 ECFLLGLMAYDRYVAICNPLLYTVVMSRRVclklAAGSYAAGFLNSLIHTT----LISRLSFCGSNVINHFFCDTPPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 LACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFL----TH 270
Cdd:cd15411 163 LSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLrpssSY 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 47575941 271 RFGHNRVpknvhifLANLYVLVPPVLNPIIYGARTKEIRSRLVK 314
Cdd:cd15411 243 SLGQDKV-------ASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
35-301 3.09e-58

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 188.46  E-value: 3.09e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  35 IAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHS 114
Cdd:cd15912   3 LFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 115 IYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIAR 194
Cdd:cd15912  83 LGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 LACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFL----TH 270
Cdd:cd15912 163 LSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVrpsqSS 242
                       250       260       270
                ....*....|....*....|....*....|.
gi 47575941 271 RFGHNRVPknvhiflANLYVLVPPVLNPIIY 301
Cdd:cd15912 243 SLDLNKVV-------ALLNTVVTPLLNPFIY 266
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
39-316 8.40e-57

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 185.56  E-value: 8.40e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15410  20 FLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKAISYSGCMLQFFFFCTFVVT 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFagIVRSVAIVSPFIFL--LRRLPYCSHRVMAHTYCEHMGIARLA 196
Cdd:cd15410 100 ESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVA--GSYLWGIVCSLIHTcgLLRLSFCGSNVINHFFCDLPPLLSLS 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 197 CANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNR 276
Cdd:cd15410 178 CSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIFHGTILFMYCRPSSSYSL 257
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47575941 277 -VPKNVHIFlanlYVLVPPVLNPIIYGARTKEIRSRLVKLF 316
Cdd:cd15410 258 dTDKVASVF----YTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
33-312 8.64e-57

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 184.91  E-value: 8.64e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  33 LWIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCV 112
Cdd:cd15429   1 LGLFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 113 HSIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQII----FAGIVRSVaIVSPFIFllrRLPYCSHRVMAHTYCE 188
Cdd:cd15429  81 LALGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAaaswTSGFLNSL-VQTAFTF---RLPFCGHNTINHFSCE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 189 HMGIARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFL 268
Cdd:cd15429 157 LLAVVRLACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYM 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 47575941 269 THRfghNRVPKNVHIFLANLYVLVPPVLNPIIYGARTKEIRSRL 312
Cdd:cd15429 237 RPR---SGSSALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
39-312 9.24e-57

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 185.11  E-value: 9.24e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15229   7 FLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIifAGIVRSVAIVSPFI--FLLRRLPYCSHRVMAHTYCEHMGIARLA 196
Cdd:cd15229  87 EAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQL--VGGAWALGFLYALIntLLLLNLHFCGPNEINHFSCELPSLLPLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 197 CANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNR 276
Cdd:cd15229 165 CSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSASSS 244
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47575941 277 VpknVHIFLANLYVLVPPVLNPIIYGARTKEIRSRL 312
Cdd:cd15229 245 V---LDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
41-309 9.87e-57

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 184.89  E-value: 9.87e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  41 VMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYALES 120
Cdd:cd15434   9 IFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGGTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 121 SVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVA---IVSPFIFllrRLPYCSHRVMAHTYCEHMGIARLAC 197
Cdd:cd15434  89 VLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGnslVLSPLTL---SLPRCGHHRVDHFFCEMPALIKLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 198 ANITV--NIVYGLTVALLAMGLdsILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLThrfGHN 275
Cdd:cd15434 166 VDTTAyeATIFALGVFILLFPL--SLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQ---PKN 240
                       250       260       270
                ....*....|....*....|....*....|....
gi 47575941 276 RVPKNVHIFLANLYVLVPPVLNPIIYGARTKEIR 309
Cdd:cd15434 241 SVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVK 274
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
39-304 2.90e-55

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 180.76  E-value: 2.90e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15911   7 FLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAAT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15911  87 ECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHnrvP 278
Cdd:cd15911 167 DTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNT---S 243
                       250       260
                ....*....|....*....|....*.
gi 47575941 279 KNVHIFLANLYVLVPPVLNPIIYGAR 304
Cdd:cd15911 244 RDLNKVFSLFYTVLTPLVNPLIYSLR 269
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
39-304 3.57e-55

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 180.58  E-value: 3.57e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15915   7 FLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15915  87 EAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLACG 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NIT-----VNIVYGlTVALLAmgldSILIAISYGFILRAVFRLP-SRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRF 272
Cdd:cd15915 167 DTSlnlwlLNIVTG-SIALGT----FILTLLSYIYIISFLLLKVrSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSS 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47575941 273 G----HNRVPknvhiflANLYVLVPPVLNPIIYGAR 304
Cdd:cd15915 242 GdsleQDRIV-------ALLYTVVTPVLNPLIYTLR 270
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
39-314 5.07e-55

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 180.68  E-value: 5.07e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLaILWLNANE-ISFGGCLAQMFCVHSIYA 117
Cdd:cd15409   7 FLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKML-VNFLSKNKmISFSGCAAQFFFFGFSAT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 118 LESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLAC 197
Cdd:cd15409  86 TECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKISC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 198 ANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNrv 277
Cdd:cd15409 166 TDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYA-- 243
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47575941 278 pKNVHIFLANLYVLVPPVLNPIIYGARTKEIRSRLVK 314
Cdd:cd15409 244 -LDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
39-314 9.41e-55

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 179.83  E-value: 9.41e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15413   7 FLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIIS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15413  87 ELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHN-RV 277
Cdd:cd15413 167 DTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSHSlDT 246
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47575941 278 PKNVHIFlanlYVLVPPVLNPIIYGARTKEIRSRLVK 314
Cdd:cd15413 247 DKMASVF----YTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
39-312 1.27e-54

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 179.57  E-value: 1.27e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLA-ILWLNANEISFGGCLAQMFCVHSIYA 117
Cdd:cd15916   7 FLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAgFLEPGGKVISFGGCVAQLYFFHFLGS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 118 LESSVLLAMAFDRYVAICNPLRYTTILNH---TVIAQIIFAGIVRSVAIVSPFIFllrRLPYCSHRVMAHTYCEHMGIAR 194
Cdd:cd15916  87 TECFLYTLMAYDRYLAICHPLHYPTIMTGrlcTRLATGTWVAGSLHSAIHTSLTF---RLPFCGPNRIDYFFCDIPPLLK 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 LACANITVN-IVYGLTVALLAMGLdSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLThrfG 273
Cdd:cd15916 164 LACADTTINeLVIFASIGVVALGC-FILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLR---P 239
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47575941 274 HNRVPknVHIFLANLYVLVPPVLNPIIYGARTKEIRSRL 312
Cdd:cd15916 240 GSKEA--LDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
39-314 2.02e-54

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 179.10  E-value: 2.02e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15416   7 FLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15416  87 ECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKLSCS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNRVP 278
Cdd:cd15416 167 DIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYSMDQ 246
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47575941 279 KNVhifLANLYVLVPPVLNPIIYGARTKEIRSRLVK 314
Cdd:cd15416 247 NKV---VSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
33-304 2.39e-54

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 178.33  E-value: 2.39e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  33 LWIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCV 112
Cdd:cd15914   1 LLLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 113 HSIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGI 192
Cdd:cd15914  81 HSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 193 ARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLthRF 272
Cdd:cd15914 161 LSLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYL--RL 238
                       250       260       270
                ....*....|....*....|....*....|..
gi 47575941 273 GHNrVPKNVHIFLANLYVLVPPVLNPIIYGAR 304
Cdd:cd15914 239 SKS-YSLDYDRAIAVVYAVLTPFFNPIIYSLR 269
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
39-314 3.13e-54

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 178.36  E-value: 3.13e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15412   7 FLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVIT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15412  87 EYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHN-RV 277
Cdd:cd15412 167 DTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEESvEQ 246
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47575941 278 PKNVHIFlanlYVLVPPVLNPIIYGARTKEIRSRLVK 314
Cdd:cd15412 247 SKIVAVF----YTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
39-312 4.13e-53

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 175.31  E-value: 4.13e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15942   7 FLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQI----IFAGIVRSvAIVSPFIFllrRLPYCSHRVMAHTYCEHMGIAR 194
Cdd:cd15942  87 ECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLslgtWLGGCLHS-TFQTSLTF---RLPYGQKNEVDYIFCDIPAMLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 LACANITVN-IVYGLTVALLAMGLdSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLthRFG 273
Cdd:cd15942 163 LACADTAFNeLVTFIDIGLVAMTC-FLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYL--RPG 239
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47575941 274 HNRVPKNVhifLANLYVLVPPVLNPIIYGARTKEIRSRL 312
Cdd:cd15942 240 SQDPLDGV---VAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
39-312 6.14e-53

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 174.93  E-value: 6.14e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15228   7 FLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGST 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15228  87 ECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLACA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYGLT-VALLAMGLdSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFlTHRFGHNRV 277
Cdd:cd15228 167 DTSIAETVSFTnVGLVPLTC-FLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIY-TQPTPSPVL 244
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47575941 278 PKNVHIFLanlyVLVPPVLNPIIYGARTKEIRSRL 312
Cdd:cd15228 245 VTPVQIFN----NVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
39-304 1.13e-52

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 173.94  E-value: 1.13e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15939   7 FLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15939  87 EIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACT 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITvniVYGLTVA----LLAMGLDSILIaISYGFILRAVfRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLthrfgh 274
Cdd:cd15939 167 DTY---VIGLLVVansgLICLLSFLILL-ISYIVILYSL-RTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYM------ 235
                       250       260       270
                ....*....|....*....|....*....|..
gi 47575941 275 nRVPKNVHI--FLANLYVLVPPVLNPIIYGAR 304
Cdd:cd15939 236 -RPVTTFPIdkVVAVFYTIITPMLNPLIYTLR 266
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
39-308 1.46e-52

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 174.15  E-value: 1.46e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15424   7 ILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGST 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15424  87 ECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 N--ITVNIVYGLTVALLAMGLDSILiaISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGhnr 276
Cdd:cd15424 167 DthITEAIVFGAGVLILLVPLSVIL--TSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSG--- 241
                       250       260       270
                ....*....|....*....|....*....|..
gi 47575941 277 VPKNVHIFLANLYVLVPPVLNPIIYGARTKEI 308
Cdd:cd15424 242 STPDRDKQIAVFYIVITPLLNPIIYTLRNKDV 273
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
39-312 2.35e-52

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 173.43  E-value: 2.35e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15432   7 FLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGST 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15432  87 ECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCV 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLthrFGHNRVP 278
Cdd:cd15432 167 DTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYL---QPPSNSS 243
                       250       260       270
                ....*....|....*....|....*....|....
gi 47575941 279 KNVHIFLANLYVLVPPVLNPIIYGARTKEIRSRL 312
Cdd:cd15432 244 HDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
37-314 2.73e-52

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 173.38  E-value: 2.73e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  37 IPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIY 116
Cdd:cd15407   5 IIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 117 ALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLA 196
Cdd:cd15407  85 TVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 197 CANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNR 276
Cdd:cd15407 165 CSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSM 244
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47575941 277 VP-KNVHIFlanlYVLVPPVLNPIIYGARTKEIRSRLVK 314
Cdd:cd15407 245 DTdKMASVF----YTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
39-312 3.74e-52

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 173.38  E-value: 3.74e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15414   7 FLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVrsVAIVSPFIF--LLRRLPYCSHRVMAHTYCEHMGIARLA 196
Cdd:cd15414  87 ECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYV--VGLLNTTTHttAAFFLPFCGPNVINHFFCDIPPLLSLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 197 CANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRfghNR 276
Cdd:cd15414 165 CADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPS---SS 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47575941 277 VPKNVHIFLANLYVLVPPVLNPIIYGARTKEIRSRL 312
Cdd:cd15414 242 SSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDAL 277
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
39-304 4.21e-52

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 172.85  E-value: 4.21e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15224   7 FLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15224  87 ECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCT 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLThrfghnrvP 278
Cdd:cd15224 167 DMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYAR--------P 238
                       250       260       270
                ....*....|....*....|....*....|.
gi 47575941 279 KNVHIFLAN-----LYVLVPPVLNPIIYGAR 304
Cdd:cd15224 239 KAISSFDSNklvsvLYTVVTPLLNPIIYCLR 269
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
39-314 1.14e-51

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 171.83  E-value: 1.14e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15415   7 FLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFA----GIVRSVAIVSPfiflLRRLPYCSHRVMAHTYCEHMGIAR 194
Cdd:cd15415  87 EGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGsylgGLINSLTHTIG----LLKLSFCGPNVINHYFCDIPPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 LACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGH 274
Cdd:cd15415 163 LSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQY 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 47575941 275 NRVPKNVhifLANLYVLVPPVLNPIIYGARTKEIRSRLVK 314
Cdd:cd15415 243 SLEQEKV---SAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
39-304 1.33e-51

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 171.23  E-value: 1.33e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15226   7 FSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILN-HTVIAQIIFAGIVRSVAIVSPFIFLLrRLPYCSHRVMAHTYCEHMGIARLAC 197
Cdd:cd15226  87 EMVLLIAMAFDRYVAICKPLHYLTIMSpRMCILLVVASWIIGFIHSLSQLAFVV-NLPFCGPNVVDSFFCDLPLVIKLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 198 ANI-TVNIVYGLTVALLAMGLDSILIaISYGFILRAVfRLPSRDAQHKALSTCGSHLGVILVFYIPAFFsFLTHRFGHNR 276
Cdd:cd15226 166 TDTyVLELMVVANSGLISLVCFLLLL-ISYIVILVTV-RKHSSGGSSKALSTCSAHITVVVLFFGPCIF-IYVWPFSTFP 242
                       250       260
                ....*....|....*....|....*...
gi 47575941 277 VPKnvhiFLANLYVLVPPVLNPIIYGAR 304
Cdd:cd15226 243 VDK----FLAVFYTVITPLLNPIIYTLR 266
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
39-315 1.80e-51

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 171.78  E-value: 1.80e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQM--FCVHSIY 116
Cdd:cd15406  16 FLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLffFCVFAIA 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 117 alESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAgiVRSVAIVSPFIF--LLRRLPYCSHRVMAHTYCEHMGIAR 194
Cdd:cd15406  96 --ECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAG--VYIMGLIGATVHtsCMLRLSFCGDNVINHYFCDILPLLK 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 LACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGH 274
Cdd:cd15406 172 LSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLKPSSSS 251
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47575941 275 NRVPKNVHiflANLYVLVPPVLNPIIYGARTKEIRSRLVKL 315
Cdd:cd15406 252 SMTQEKVS---SVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
39-314 6.37e-50

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 167.61  E-value: 6.37e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15945  20 FLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIPFYGCALQMFFFAAFADA 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15945 100 ECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGSNTINHFFCDIPPLLALSCS 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHN-RV 277
Cdd:cd15945 180 DTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLFYGTLLFMYLRPSSSYSlDT 259
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47575941 278 PKNVHIFlanlYVLVPPVLNPIIYGARTKEIRSRLVK 314
Cdd:cd15945 260 DKMTSVF----YTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
39-312 6.44e-49

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 164.56  E-value: 6.44e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15236   7 FLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15236  87 DSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNRVP 278
Cdd:cd15236 167 STSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSSDK 246
                       250       260       270
                ....*....|....*....|....*....|....
gi 47575941 279 KnvhIFLANLYVLVPPVLNPIIYGARTKEIRSRL 312
Cdd:cd15236 247 D---IVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
37-316 3.43e-48

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 163.42  E-value: 3.43e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  37 IPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIY 116
Cdd:cd15944  18 VVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKVISFSGCATQFAFFVGFV 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 117 ALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLA 196
Cdd:cd15944  98 DAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGSNIINHFFCDVPPLLALS 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 197 CANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLThrfghnr 276
Cdd:cd15944 178 CSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLFYGTVIFMYLR------- 250
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 47575941 277 vPKNVHIF-----LANLYVLVPPVLNPIIYGARTKEIRSRLVKLF 316
Cdd:cd15944 251 -PTSVYSLdqdkwASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
39-304 8.64e-48

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 161.49  E-value: 8.64e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15946   7 FLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGIT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15946  87 ECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKLACA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVN--IVYGLTVALLAMGLDsiLIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLthRFGHNR 276
Cdd:cd15946 167 DTSLNemVDFVLGVIVLVVPLS--LILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYM--RPGSNY 242
                       250       260
                ....*....|....*....|....*...
gi 47575941 277 VPkNVHIFLANLYVLVPPVLNPIIYGAR 304
Cdd:cd15946 243 SP-ERDKKISLFYNVFTALLNPVIYSLR 269
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
39-309 1.84e-47

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 161.05  E-value: 1.84e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15405   7 FLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVIS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15405  87 ECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSCT 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGhnrVP 278
Cdd:cd15405 167 STYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSV---GS 243
                       250       260       270
                ....*....|....*....|....*....|.
gi 47575941 279 KNVHIFLANLYVLVPPVLNPIIYGARTKEIR 309
Cdd:cd15405 244 VNQGKVSSVFYTNVVPMLNPLIYSLRNKDVK 274
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
41-312 6.88e-47

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 159.57  E-value: 6.88e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  41 VMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYALES 120
Cdd:cd15433   9 IFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 121 SVLLAMAFDRYVAICNPLRYTTILN----HTVIAQIIFAGIVRSVAIVSpfifLLRRLPYCSHRVMAHTYCEHMGIARLA 196
Cdd:cd15433  89 VLLAVMAFDRYAAVCRPLHYAALMSprlcQTLASISWLSGFVNSVAQTG----LLAERPLCGHRLLDHFFCEMPVFLKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 197 CANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFL--THRFGH 274
Cdd:cd15433 165 CGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLqpIHRYSQ 244
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47575941 275 NRVPknvhiFLANLYVLVPPVLNPIIYGARTKEIRSRL 312
Cdd:cd15433 245 AHGK-----FVSLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
39-304 8.01e-47

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 159.02  E-value: 8.01e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15913   7 FSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15913  87 ECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLALSCV 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHnrvP 278
Cdd:cd15913 167 PAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGN---S 243
                       250       260
                ....*....|....*....|....*.
gi 47575941 279 KNVHIFLANLYVLVPPVLNPIIYGAR 304
Cdd:cd15913 244 TGMQKIVTLFYSVVTPLLNPLIYSLR 269
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
39-304 1.57e-46

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 158.27  E-value: 1.57e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15936   7 FLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFA----GIVRSVAIVSpfifLLRRLPYCSHRVMAHTYCEHMGIAR 194
Cdd:cd15936  87 EVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGswlgGFAHSIVQVA----LLLQLPFCGPNVLDNFYCDVPQVIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 LACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVfRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFlTHRFGH 274
Cdd:cd15936 163 LACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKI-RTHVTEGKRKALSTCASQITVVTLIFVPCIYIY-ARPFQT 240
                       250       260       270
                ....*....|....*....|....*....|
gi 47575941 275 NRVPKNVHIflanLYVLVPPVLNPIIYGAR 304
Cdd:cd15936 241 FPMDKAVSV----LYTVITPMLNPMIYTLR 266
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
39-312 3.42e-46

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 157.70  E-value: 3.42e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHA-PMYLFLCLLSLTDLALSSTTVPKMLA-ILWLNANEISFGGCLAQMFCVHSIY 116
Cdd:cd15941   7 FLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAgLLTLSGRTISFEGCVVQLYAFHFLA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 117 ALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIifAGIVRSVAIVSPFIF--LLRRLPYCSHRVMAHTYCEHMGIAR 194
Cdd:cd15941  87 STECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGL--AGGTWATGATHAAIHtsLTFRLPYCGPCQIAYFFCDIPPVLK 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 LACANITVN-IVYGLTVALLAMGLdSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRfg 273
Cdd:cd15941 165 LACADTTINeLVILANIGIVAAGC-FLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS-- 241
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47575941 274 HNRVPKNVhifLANLYVLVPPVLNPIIYGARTKEIRSRL 312
Cdd:cd15941 242 SSQAGAGA---PAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
39-304 1.10e-45

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 156.06  E-value: 1.10e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15940   7 FLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFA----GIVRSVAIVspfiFLLRRLPYCSHRVMAHTYCEHMGIAR 194
Cdd:cd15940  87 EIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAAlwlgGTVHSLAQT----FLTIRLPYCGPNEIDSFFCDVPPVIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 LACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVfRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGH 274
Cdd:cd15940 163 LACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSL-RKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSF 241
                       250       260       270
                ....*....|....*....|....*....|
gi 47575941 275 NrVPKNVHIFlanlYVLVPPVLNPIIYGAR 304
Cdd:cd15940 242 S-EDKVVSVF----YTVVTPLLNPIIYTLR 266
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
37-312 1.41e-44

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 153.40  E-value: 1.41e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  37 IPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIY 116
Cdd:cd15428   5 ILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 117 ALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIF----AGIVRSVaIVSPFIFllrRLPYCSHRVMAHTYCEHMGI 192
Cdd:cd15428  85 ITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATgswvGGLLVSA-VDTAFTL---NLSFGGHNKINHFLCEMPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 193 ARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRf 272
Cdd:cd15428 161 LKLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPK- 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 47575941 273 ghNRVPKNVHIFLANLYVLVPPVLNPIIYGARTKEIRSRL 312
Cdd:cd15428 240 --SSTSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
39-315 4.00e-44

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 152.24  E-value: 4.00e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15418   8 FLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15418  88 ECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACD 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFL----THRFGH 274
Cdd:cd15418 168 DTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSrpssSHTPDR 247
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47575941 275 NRVpknvhifLANLYVLVPPVLNPIIYGARTKEIRSRLVKL 315
Cdd:cd15418 248 DKV-------VALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
39-312 6.39e-43

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 149.17  E-value: 6.39e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15233   7 FLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15233  87 DCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSCS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYgLTVALLAMGLDSI-LIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNRV 277
Cdd:cd15233 167 STHLNELL-LFVFAFFMALAPCvLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVYSSD 245
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47575941 278 PKNVhifLANLYVLVPPVLNPIIYGARTKEIRSRL 312
Cdd:cd15233 246 KDKV---IGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
43-304 1.85e-41

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 144.91  E-value: 1.85e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  43 YLIALLGNAALILIIGTESAL-HAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYALESS 121
Cdd:cd15935  11 YAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEML 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 122 VLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACANIT 201
Cdd:cd15935  91 LLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIKLACMDTY 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 202 VniVYGLTVA---LLAMGLDSILIaISYGFILrAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLThRFGHNRVP 278
Cdd:cd15935 171 V--VEVLMVAnsgLLSLVCFLVLL-VSYGIIL-TTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLR-PFSSSSVD 245
                       250       260
                ....*....|....*....|....*.
gi 47575941 279 KNVHIFlanlYVLVPPVLNPIIYGAR 304
Cdd:cd15935 246 KVASVF----YTLITPALNPLIYTLR 267
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
39-304 3.60e-39

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 139.10  E-value: 3.60e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15937   7 FLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFA----GIVRSVAIVSpfifLLRRLPYCSHRVMAHTYCEHMGIAR 194
Cdd:cd15937  87 EMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGAswagGFIHSIIQVA----LIIRLPFCGPNVLDNFFCDITQVIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 LACANITVNIVYGLTVALLAMGLDSILIAISYGFILrAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFlTHRFGH 274
Cdd:cd15937 163 LACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLL-AKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIY-ARPFRS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 47575941 275 NRVPKNVHIFlanlYVLVPPVLNPIIYGAR 304
Cdd:cd15937 241 FPMDKVVAVF----HTVIFPLLNPMIYTLR 266
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
39-304 7.67e-38

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 135.39  E-value: 7.67e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15938   7 FLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARLACA 198
Cdd:cd15938  87 EMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACT 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 199 NITVNIVYGLTVALLAMGLDSILIAISYGFILravFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLtHRFGHNRVP 278
Cdd:cd15938 167 DTCVTELLMVSNSGLISTVCFVVLVTSYTTIL---VTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYA-RPFSTFPVD 242
                       250       260
                ....*....|....*....|....*.
gi 47575941 279 KNVHIflanLYVLVPPVLNPIIYGAR 304
Cdd:cd15938 243 KHVSV----LYNVITPMLNPLIYTLR 264
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
49-301 9.61e-26

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 103.15  E-value: 9.61e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941    49 GNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILwLNANEISFG--GCLAQMFCVhsIYALESSV--LL 124
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYY-LNHGDWPFGsaLCKIVGALF--VVNGYASIllLT 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941   125 AMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRlpyCSHRVMAHTYCEHMGIARLACaNITVNI 204
Cdd:pfam00001  78 AISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWT---LTVPEGNVTVCFIDFPEDLSK-PVSYTL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941   205 VYGLTVALLAMgldsILIAISYGFILRAVF-------RLPSRDAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNRV 277
Cdd:pfam00001 154 LISVLGFLLPL----LVILVCYTLIIRTLRksaskqkSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCE 229
                         250       260
                  ....*....|....*....|....*..
gi 47575941   278 PKNVH---IFLANLYVLVPPVLNPIIY 301
Cdd:pfam00001 230 LSRLLdkaLSVTLWLAYVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
35-304 1.47e-19

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 86.57  E-value: 1.47e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  35 IAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHS 114
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 115 IYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCehmgiar 194
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWP------- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 lacaNITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFR--------------LPSRDAQHKALSTCGSHLGVILVFY 260
Cdd:cd00637 154 ----DLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRhrrrirssssnssrRRRRRRERKVTKTLLIVVVVFLLCW 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 47575941 261 IPAFFSFLTHRFGHNRVPKNVHI-FLANLYVLVPPVLNPIIYGAR 304
Cdd:cd00637 230 LPYFILLLLDVFGPDPSPLPRILyFLALLLAYLNSAINPIIYAFF 274
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
34-309 1.41e-14

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 72.21  E-value: 1.41e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  34 WIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQ----- 108
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWialdv 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 109 MFCVHSIYALessvlLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCShrvMAHTYCE 188
Cdd:cd14967  81 LCCTASILNL-----CAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPS---VVDCECE 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 189 HmgiarlacaniTVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRlpsrdaQHKALSTCGSHLGVILVFYIPAFFSFL 268
Cdd:cd14967 153 F-----------TPNKIYVLVSSVISFFIPLLIMIVLYARIFRVARR------ELKAAKTLAIIVGAFLLCWLPFFIIYL 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 47575941 269 THRF-GHNRVPKNVHIFLANLyVLVPPVLNPIIYGARTKEIR 309
Cdd:cd14967 216 VSAFcPPDCVPPILYAVFFWL-GYLNSALNPIIYALFNRDFR 256
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
40-235 2.90e-09

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 56.86  E-value: 2.90e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  40 CVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLAlssTTVPKMLAILWLNANEISFGG---C-LAQMFCVHSI 115
Cdd:cd15196   8 ATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLL---VALFNVLPQLIWDITYRFYGGdllCrLVKYLQVVGM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 116 YAlESSVLLAMAFDRYVAICNPLRY---TTILNHTVIAQIIFAGIVRSVAIVspFIFLLRRLPYCSHRVMAHTYCEhmgi 192
Cdd:cd15196  85 YA-SSYVLVATAIDRYIAICHPLSShrwTSRRVHLMVAIAWVLSLLLSIPQL--FIFSYQEVGSGVYDCWATFEPP---- 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 47575941 193 arlacaniTVNIVYGLTVALLAMGLDSILIAISYGFILRAVFR 235
Cdd:cd15196 158 --------WGLRAYITWFTVAVFVVPLIILAFCYGRICYVVWR 192
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
44-301 1.49e-08

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 54.74  E-value: 1.49e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  44 LIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkmLAILWLNANEISFGGCLAQMFCVHSIYALESSV- 122
Cdd:cd15050  12 LITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMP--LNIVYLLESKWILGRPVCLFWLSMDYVASTASIf 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 123 -LLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPfIFLLRRLPYCSHRVMAHTYCEhmgiarlacANIT 201
Cdd:cd15050  90 sLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIP-ILGWHHFARGGERVVLEDKCE---------TDFH 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 202 VNIVYGLTVALLAMGLDSILIAISYGFILRAVFRlpsrdaQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNRVPKNV 281
Cdd:cd15050 160 DVTWFKVLTAILNFYIPSLLMLWFYAKIFKAVNR------ERKAAKQLGFIMAAFILCWIPYFILFMVIAFCKNCCNENL 233
                       250       260
                ....*....|....*....|
gi 47575941 282 HIFLANLYVLvPPVLNPIIY 301
Cdd:cd15050 234 HMFTIWLGYI-NSTLNPFIY 252
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
37-312 1.76e-08

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 54.69  E-value: 1.76e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  37 IPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVpkMLAILWLNANEISFGGCLAQMFCVHSIY 116
Cdd:cd14986   5 AVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTV--LTQIIWEATGEWVAGDVLCRIVKYLQVV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 117 ALESS--VLLAMAFDRYVAICNPLRytTILNHTVIAQIIFAGIVRS--VAIVSPFIFLLRRLPYCSHRVMAHTYCEhmgi 192
Cdd:cd14986  83 GLFAStyILVSMSLDRYQAIVKPMS--SLKPRKRARLMIVVAWVLSflFSIPQLVIFVERELGDGVHQCWSSFYTP---- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 193 arlacANITVNIVYGLTVALLAmglDSILIAISYGFILRAVF--------RLPSRDAQHKALSTCGSHLG---------- 254
Cdd:cd14986 157 -----WQRKVYITWLATYVFVI---PLIILSYCYGRILRTIWirsrqktdRPIAPTAMSCRSVSCVSSRVslisrakikt 228
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47575941 255 -----VILVFYI----PAFFSFLTHRFGHNRVPKNVHIFLANLYVLVPPVLNPIIYGARTKEIRSRL 312
Cdd:cd14986 229 ikmtlVIILAFIlcwtPYFIVQLLDVYAGMQQLENDAYVVSETLASLNSALNPLIYGFFSSHLSFEH 295
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
44-155 1.69e-07

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 51.87  E-value: 1.69e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  44 LIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkmLAILWLNANEISFGGCL-----AQMFCVHSIYAL 118
Cdd:cd14968  12 VLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCLfmaclVLVLTQSSIFSL 89
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 47575941 119 essvlLAMAFDRYVAICNPLRYTTILNHTVIAQIIFA 155
Cdd:cd14968  90 -----LAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAV 121
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
35-310 4.60e-07

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 50.41  E-value: 4.60e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  35 IAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkmLAILWLNANEISFGGCLAQMFCVHS 114
Cdd:cd15064   3 ISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMP--LSAVYELTGRWILGQVLCDIWISLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 115 IYALESSV--LLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFlLRRLPYcshrVMAHTYCEhmgi 192
Cdd:cd15064  81 VTCCTASIlhLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLF-GWRTPD----SEDPSECL---- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 193 arlacanITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRlpsrdaQHKALSTCGSHLGVILVFYIPAFFSFLTHRF 272
Cdd:cd15064 152 -------ISQDIGYTIFSTFGAFYIPLLLMLILYWKIYRAAAR------ERKAAKTLGIILGAFIVCWLPFFLVALIVPL 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 47575941 273 -GHNRVPKNVHIFLANL-YvlVPPVLNPIIYGARTKEIRS 310
Cdd:cd15064 219 cSHCWIPLALKSFFLWLgY--FNSLINPLIYTFFNKDFRK 256
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
41-301 1.82e-06

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 48.74  E-value: 1.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  41 VMYLIALL---GNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAI----LWLnaneisFGGCLAQMFCVH 113
Cdd:cd15958   6 LMALIVLLivaGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLvvrgRWL------YGSFFCELWTSV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 114 SIYALESSV--LLAMAFDRYVAICNPLRYTTILNHTVIaqiifAGIVRSVAIVSPFIFLLrrlpycshRVMAHTYCEHMG 191
Cdd:cd15958  80 DVLCVTASIetLCVIAIDRYLAITSPFRYQSLLTRARA-----KGIVCTVWAISALVSFL--------PIMMHWWRDEDD 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 192 IARL-----ACANITVNIVYGLTVALLAMGLDSILIAISYGFILR-------------------------AVFRLPSR-- 239
Cdd:cd15958 147 QALKcyedpGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYReakkqikkidkcegrfhntltglgrKCKRRPSRil 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47575941 240 -DAQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNRVPKNVHIFLaNLYVLVPPVLNPIIY 301
Cdd:cd15958 227 aLREQKALKTLGIIMGVFTLCWLPFFLVNVVNVFNRELVPDWLFVFF-NWLGYANSAFNPIIY 288
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
44-169 1.95e-06

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 48.70  E-value: 1.95e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  44 LIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVP----KMLAILWLNANEI-SFGGCLAQMFCVHSIYAL 118
Cdd:cd15318  12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPfstiRSVESCWYFGDSFcRLHTCLDTLFCLTSIFHL 91
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 47575941 119 essvlLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIF 169
Cdd:cd15318  92 -----CFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVFLY 137
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
34-257 2.05e-06

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 48.36  E-value: 2.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  34 WIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkmLAILWLNANEISFGgclaQMFCVH 113
Cdd:cd14993   2 VLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMP--LTLLENVYRPWVFG----EVLCKA 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 114 SIY----ALESSV--LLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVM--AHT 185
Cdd:cd14993  76 VPYlqgvSVSASVltLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEPGtiTIY 155
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47575941 186 YC-EHMGIARLACANITVnivygLTVALLAMGLdsILIAISYGFIlraVFRLPSRDAQHKALSTCGSHLGVIL 257
Cdd:cd14993 156 ICtEDWPSPELRKAYNVA-----LFVVLYVLPL--LIISVAYSLI---GRRLWRRKPPGDRGSANSTSSRRIL 218
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
40-154 3.61e-06

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 47.73  E-value: 3.61e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  40 CVMY-------LIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVP----KMLAILWLnaneisFG----- 103
Cdd:cd15312   1 VAMYlfmagaiLLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPysmvRSVESCWY------FGdlfck 74
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 47575941 104 --GCLAQMFCVHSIYALESsvllaMAFDRYVAICNPLRYTTILNHTVIAQIIF 154
Cdd:cd15312  75 ihSSLDMMLSTTSIFHLCF-----IAVDRYYAVCDPLHYRTKITTPVIKVFLV 122
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
41-310 4.06e-06

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 47.59  E-value: 4.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  41 VMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAIL----WLnaneisFGGCLAQMFCVHSIY 116
Cdd:cd15959   9 LAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILltghWP------LGTTVCELWTSVDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 117 ALESSV--LLAMAFDRYVAICNPLRYTTIlnhtvIAQIIFAGIVRSVAIVSPFIFLLrrlPYCSH--RVMAHTYCEHMGI 192
Cdd:cd15959  83 CVTASIetLCAIAVDRYLAITNPLRYEAL-----VTKRRARTAVCLVWAISAAISFL---PIMNQwwRDGADEEAQRCYD 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 193 ARLACANITvNIVYGLTVALLAMGLDSILIAISYGFIL----------------------------RAVFRLPSR---DA 241
Cdd:cd15959 155 NPRCCDFVT-NMPYAIVSSTVSFYVPLLVMIFVYVRVFvvatrqvrlirkdkvrfppeesppaesrPACGRRPSRllaIK 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47575941 242 QHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNRVPKNVHIFLaNLYVLVPPVLNPIIYgARTKEIRS 310
Cdd:cd15959 234 EHKALKTLGIIMGTFTLCWLPFFVANIIKVFCRSLVPDPAFLFL-NWLGYANSAFNPIIY-CRSPDFRS 300
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
39-153 5.33e-06

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 47.21  E-value: 5.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANE-------ISFGGCLAQMFC 111
Cdd:cd15353   7 FVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNGNDtdaqsftVNIDNVIDSVIC 86
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 47575941 112 VHSIYALESsvLLAMAFDRYVAICNPLRYTTILNHTVIAQII 153
Cdd:cd15353  87 SSLLASICS--LLSIAVDRYFTIFYALQYHNIMTVRRAGVII 126
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
41-168 6.60e-06

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 46.85  E-value: 6.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  41 VMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkmLAILWLNANEISFGGCLaqMFCVHSIYALES 120
Cdd:cd15069   9 IIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIP--FAITISLGFCTDFHSCL--FLACFVLVLTQS 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 47575941 121 SV--LLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAI-VSPFI 168
Cdd:cd15069  85 SIfsLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIgLTPFL 135
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
35-309 8.39e-06

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 46.52  E-value: 8.39e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  35 IAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHS 114
Cdd:cd14972   1 VLVVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 115 IYALESSvLLAMAFDRYVAICNPLRYTTILNHtviaqiifAGIVRSVAIVSPFIFLLRRLPycsHRVMAHTYCEHMGIAR 194
Cdd:cd14972  81 LLASAYS-LLAIAVDRYISIVHGLTYVNNVTN--------KRVKVLIALVWVWSVLLALLP---VLGWNCVLCDQESCSP 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 LACANITVNIVYGLTVALLAMgldsILIAISYGFILRAVFRLPSRDAQH-------------KALSTCGSHLGVILVFYI 261
Cdd:cd14972 149 LGPGLPKSYLVLILVFFFIAL----VIIVFLYVRIFWCLWRHANAIAARqeaavpaqpstsrKLAKTVVIVLGVFLVCWL 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 47575941 262 PAF--FSFLTHRFGHNRVPKNVHIFLanLYVLVPPVLNPIIYGARTKEIR 309
Cdd:cd14972 225 PLLilLVLDVLCPSVCDIQAVFYYFL--VLALLNSAINPIIYAFRLKEMR 272
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
39-309 1.34e-05

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 46.08  E-value: 1.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQ--------MF 110
Cdd:cd15354   7 FLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRhidnvfdsLI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 111 CVHSIYALESsvLLAMAFDRYVAICNPLRYTTILNhtviaqiifagiVRSVAIVSPFIFllrrlpycshrvmahTYCEHM 190
Cdd:cd15354  87 CISVVASMCS--LLAIAVDRYVTIFYALRYHNIMT------------VRRAGIIIACIW---------------TFCTGC 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 191 GIARLACANIT------VNIVYGLTVALLAMGLDSILIAISYgfiLRAVFRLPSRDAQHKALSTCGS-HLGVILVFYIPA 263
Cdd:cd15354 138 GIIFILYSESTyviiclITMFFAMLFLMVSLYIHMFLLARTH---VKRIAALPGYNSVRQRTSMKGAvTLTILLGIFIVC 214
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 47575941 264 FFSFLTHRFGHNRVPKNV-------HIFLANLYVLVPPVLNPIIYGARTKEIR 309
Cdd:cd15354 215 WAPFFLHLILMISCPQNLycvcfmsHFNMYLILIMCNSVIDPLIYAFRSQEMR 267
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
39-171 1.53e-05

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 45.65  E-value: 1.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQ--------MF 110
Cdd:cd15352   7 FLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQhmdnvfdsMI 86
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47575941 111 CVHSIYALESsvLLAMAFDRYVAICNPLRYTTILnhTVIAQIIFAGIVRSVAIVSPFIFLL 171
Cdd:cd15352  87 CISLVASICN--LLAIAVDRYVTIFYALRYHSIM--TVRKALVLIAVIWVVCIVCGIVFIV 143
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
41-310 1.56e-05

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 45.79  E-value: 1.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  41 VMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkmLAILWLNANEISFGGCLAQ-------MFCVH 113
Cdd:cd15051   9 VIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLP--FSAIYELRGEWPLGPVFCNiyisldvMLCTA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 114 SIYALessvlLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAH-TYCEhmgi 192
Cdd:cd15051  87 SILNL-----FAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIHLGWNTPDGRVQNGDTpNQCR---- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 193 arlacanITVNIVYGLTVALLAMGLDSILIAISYGFILR--------------AVFRLPSRDAQ----HKALSTCGSHLG 254
Cdd:cd15051 158 -------FELNPPYVLLVAIGTFYLPLLIMCGVYLRIFRiareqakrinaltpASTANSSKSAAtareHKATVTLAAVLG 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47575941 255 VILVFYIPAFFSFLTHRFGHNRVPKNVHIFLANL-YvlVPPVLNPIIYGARTKEIRS 310
Cdd:cd15051 231 AFIICWFPYFTYFTYRGLCGDNINETALSVVLWLgY--ANSALNPILYAFLNRDFRR 285
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
39-170 1.67e-05

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 45.74  E-value: 1.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkmLAILWLNANEISFGG---CLAQMFCVHSI 115
Cdd:cd14997   7 YGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMP--VALVETWAREPWLLGefmCKLVPFVELTV 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47575941 116 YALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFL 170
Cdd:cd14997  85 AHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFI 139
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
41-169 2.08e-05

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 45.41  E-value: 2.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  41 VMYLIaLLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLailwlnANEI----SFGGCLAQMFCVHSIY 116
Cdd:cd15059  10 VILLI-IVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSL------VNELmgywYFGSVWCEIWLALDVL 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47575941 117 ALESSV--LLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIF 169
Cdd:cd15059  83 FCTASIvnLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLF 137
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
34-310 5.53e-05

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 44.36  E-value: 5.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  34 WIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGC----LAQM 109
Cdd:cd15058   2 GLLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCelwtSVDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 110 FCV-HSIyalesSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFagivrSVAIVSPFIFLlrrLPYCSHRVMAHTYCE 188
Cdd:cd15058  82 LCVtASI-----ETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVC-----VVWIVSALVSF---VPIMNQWWRANDPEA 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 189 HMGIARLACANITVNIVYGLTVALLAMGLdSILIAIsygFILRAVFRLPSRDAQ-------------------------- 242
Cdd:cd15058 149 NDCYQDPTCCDFRTNMAYAIASSVVSFYI-PLLIMI---FVYARVFLIATRQLQlidkrrlrfqsecpapqttspegkrs 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 243 -------------HKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNRVPKNVHIFLaNLYVLVPPVLNPIIYgARTKEIR 309
Cdd:cd15058 225 sgrrpsrltvvkeHKALKTLGIIMGTFTLCWLPFFIANIINVFNRNLPPGEVFLLL-NWLGYINSGLNPIIY-CRSPEFR 302

                .
gi 47575941 310 S 310
Cdd:cd15058 303 T 303
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
34-264 5.88e-05

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 44.02  E-value: 5.88e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  34 WIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTV-PKMLAILW----LNANEISFGGCLAQ 108
Cdd:cd15054   2 WVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMpPAMLNALYgrwvLARDFCPIWYAFDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 109 MFCVHSIYAlessvLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAgiVRSVAIVSPFIFLLRRLPYCSH--RVMAHTY 186
Cdd:cd15054  82 MCCSASILN-----LCVISLDRYLLIISPLRYKLRMTPPRALALILA--AWTLAALASFLPIELGWHELGHerTLPNLTS 154
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47575941 187 CEHMGIARLacaniTVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRlpsrdaQHKALSTCGSHLGVILVFYIPAF 264
Cdd:cd15054 155 GTVEGQCRL-----LVSLPYALVASCLTFFLPSGAICFTYCRILLAARK------ALKASLTLGILLGMFFVTWLPFF 221
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
37-302 6.34e-05

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 43.70  E-value: 6.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  37 IPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkmLAILWlnaneiSFGGC--LAQMFC-VH 113
Cdd:cd15055   5 IVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMP--FSMIR------SIETCwyFGDTFCkLH 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 114 SI--YALESSVLLAM---AFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPycshRVMAHTYCe 188
Cdd:cd15055  77 SSldYILTSASIFNLvliAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDNLNQP----GLIRYNSC- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 189 hMGiarlACAnITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFR-------------------LPSRDAQHKALSTC 249
Cdd:cd15055 152 -YG----ECV-VVVNFIWGVVDLVLTFILPCTVMIVLYMRIFVVARSqarairshtaqvslegsskKVSKKSERKAAKTL 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 47575941 250 GSHLGVILVFYIPAFFSFLTHRF-GHNRVPKNVHIFLanlyVLVPPVLNPIIYG 302
Cdd:cd15055 226 GIVVGVFLLCWLPYYIVSLVDPYiSTPSSVFDVLIWL----GYFNSCLNPLIYA 275
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
36-176 7.76e-05

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 43.49  E-value: 7.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  36 AIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWlNANEISFGGCLAQMFCVHSI 115
Cdd:cd15053   4 ALFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEV-NGGKWYLGPILCDIYIAMDV 82
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47575941 116 YALESSV--LLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPY 176
Cdd:cd15053  83 MCSTASIfnLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPY 145
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
38-165 7.97e-05

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 43.77  E-value: 7.97e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  38 PFCVMYLIALLGNAALILIIGTESALH--APMYLFLCLLSLTDLALSSTTVPKMLAiLWLNANEISFGGCLAQMFCVHSI 115
Cdd:cd14981   6 PPALMFVFGVLGNLLALIVLARSSKSHkwSVFYRLVAGLAITDLLGILLTSPVVLA-VYASNFEWDGGQPLCDYFGFMMS 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47575941 116 YALESSVLL--AMAFDRYVAICNPLRYTTILNHTvIAQIIFAGIVRSVAIVS 165
Cdd:cd14981  85 FFGLSSLLIvcAMAVERFLAITHPFFYNSHVKKR-RARLMLGAVWAFALLIA 135
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
35-264 8.59e-05

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 43.25  E-value: 8.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  35 IAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkmLAILWLNANEISFGGCLAQMFCVHS 114
Cdd:cd15333   7 LAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMP--ISIVYTVTGTWTLGQVVCDIWLSSD 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 115 IYALESSV--LLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPfifllrrlPYCSHRVMAHTYCEHmgi 192
Cdd:cd15333  85 ITCCTASIlhLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLP--------PFFWRQAKAEEEVSE--- 153
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47575941 193 arlaCANITVNIVYGLTVALLAMGLDSILIAISYGFILRAvfrlpSRDAQHKALSTCGSHLGVILVFYIPAF 264
Cdd:cd15333 154 ----CVVNTDHILYTVYSTVGAFYIPTLLLIALYGRIYVE-----ARARERKATKTLGIILGAFIVCWLPFF 216
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
39-309 9.43e-05

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 43.25  E-value: 9.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQ--------MF 110
Cdd:cd15103   7 FLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQhidnvidsMI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 111 CVHSIYALESsvLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFllrrlpycshrvmahtYCEHm 190
Cdd:cd15103  87 CSSLLASICS--LLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFII----------------YSDS- 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 191 giarlacanitVNIVYGLTVALLAMgldSILIAISYGFIL-------RAVFRLPSRDAQHKALSTCGS-----HLGVILV 258
Cdd:cd15103 148 -----------VPVIICLISMFFAM---LVLMASLYVHMFllarshvKKIAALPGQRSTRQRANMKGAvtltiLLGVFIF 213
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 47575941 259 FYIPAFFSFLTHRFGHNRVPKNVHIFLANLY---VLVPPVLNPIIYGARTKEIR 309
Cdd:cd15103 214 CWAPFFLHLTLMISCPSNPYCACYMSHFNVYlilIMCNSVIDPLIYAFRSQELR 267
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
35-231 1.10e-04

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 43.36  E-value: 1.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  35 IAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVP-KMLAILWLNAneiSFGGCLAQM---- 109
Cdd:cd15203   3 LILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPfTLIYTLTKNW---PFGSILCKLvpsl 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 110 FCVhSIYaLESSVLLAMAFDRYVAICNPLRytTILNHTVIAQIIFAGIVRSVAIVSPFIFllrrlpycsHRVMAHTYCEH 189
Cdd:cd15203  80 QGV-SIF-VSTLTLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLSLPLAI---------FQELSDVPIEI 146
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 47575941 190 MGIARLAC----ANITVNIVYGLTVALLAMGLDSILIAISYGFILR 231
Cdd:cd15203 147 LPYCGYFCteswPSSSSRLIYTISVLVLQFVIPLLIISFCYFRISL 192
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
44-309 1.11e-04

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 42.96  E-value: 1.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  44 LIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNAneISFGGCLAQMFCVHSIYALESSV- 122
Cdd:cd15326  12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGY--WVFGRIFCDIWAAVDVLCCTASIl 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 123 -LLAMAFDRYVAICNPLRYTTILNHTviaQIIFAgiVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEhmgiarlacanIT 201
Cdd:cd15326  90 sLCAISIDRYIGVRHSLQYPTIVTRK---RAILA--LLGVWVLSTVISIGPLLGWKEPAPPDDKVCE-----------IT 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 202 VNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLpSRdaQHKALSTCGSHLGVILVFYIPAFFSF-LTHRFGHNRVPKN 280
Cdd:cd15326 154 EEPFYALFSSLGSFYIPLIVILVMYCRVYIVALKF-SR--EKKAAKTLGIVVGMFILCWLPFFIALpLGSLFSHLKPPET 230
                       250       260       270
                ....*....|....*....|....*....|.
gi 47575941 281 VH--IFLANLYvlvPPVLNPIIYGARTKEIR 309
Cdd:cd15326 231 LFkiIFWLGYF---NSCLNPIIYPCSSKEFK 258
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
42-310 1.13e-04

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 43.04  E-value: 1.13e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  42 MYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkmLAILWLNANEISFGGCLAQMFCVHSIYALESS 121
Cdd:cd15330  10 LILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLP--MAALYQVLNKWTLGQVTCDLFIALDVLCCTSS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 122 V--LLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIfLLRRLPYCSHRVMAHTYCEHMGiarlacan 199
Cdd:cd15330  88 IlhLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPM-LGWRTPEDRSDPDACTISKDPG-------- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 200 itvnivYGLTVALLAMGLDSILIAISYGFILRAVFRlpsrdaQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNRVPK 279
Cdd:cd15330 159 ------YTIYSTFGAFYIPLILMLVLYGRIFKAAAR------ERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESTCHM 226
                       250       260       270
                ....*....|....*....|....*....|..
gi 47575941 280 NVHIF-LANLYVLVPPVLNPIIYGARTKEIRS 310
Cdd:cd15330 227 PELLGaIINWLGYSNSLLNPIIYAYFNKDFQS 258
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
41-172 1.38e-04

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 42.86  E-value: 1.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  41 VMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTV-PKMLailWlnanEISFGGCLAQMFC-------V 112
Cdd:cd15386   9 AILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFQVlPQLI---W----EITYRFQGPDLLCravkylqV 81
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47575941 113 HSIYAlESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSV-AIVSPFIFLLR 172
Cdd:cd15386  82 LSMFA-STYMLIMMTVDRYIAVCHPLRTLQQPSRQAYLMIGATWLLSCIlSLPQVFIFSLR 141
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-139 1.80e-04

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 42.50  E-value: 1.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  40 CVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTV-PKMLAILWLNANEISFGGCLAQMFCVHSIYAl 118
Cdd:cd15387   8 ALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFQVlPQLIWDITFRFYGPDFLCRLVKYLQVVGMFA- 86
                        90       100
                ....*....|....*....|.
gi 47575941 119 ESSVLLAMAFDRYVAICNPLR 139
Cdd:cd15387  87 STYMLLLMSIDRCLAICQPLR 107
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
33-140 1.82e-04

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 42.22  E-value: 1.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  33 LWIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkmLAILWLNANEISFGGCLAQMFCV 112
Cdd:cd15335   1 MLIVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMP--LSITYIVMDTWTLGYFICEIWLS 78
                        90       100       110
                ....*....|....*....|....*....|
gi 47575941 113 HSIYALESSV--LLAMAFDRYVAICNPLRY 140
Cdd:cd15335  79 VDMTCCTCSIlhLCVIALDRYWAITDAIEY 108
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
40-143 1.98e-04

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 42.46  E-value: 1.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  40 CVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkmLAILWLNANEISFGGCLAqMFCVHSIYALE 119
Cdd:cd15070   8 ILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLF-MSCLLVVFTHA 84
                        90       100
                ....*....|....*....|....*
gi 47575941 120 SSV-LLAMAFDRYVAICNPLRYTTI 143
Cdd:cd15070  85 SIMsLLAIAVDRYLRVKLTVRYRIV 109
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
41-309 2.12e-04

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 42.54  E-value: 2.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  41 VMYLIAL---LGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNAneISFGGCLAQMFCVHSIYA 117
Cdd:cd15957   6 VMSLIVLaivFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKT--WTFGNFWCEFWTSIDVLC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 118 LESSV--LLAMAFDRYVAICNPLRYTTILNHTVIAQIIFagIVRSVAIVSPFifllrrLPYCSHRVMAHTYCEHMGIARL 195
Cdd:cd15957  84 VTASIetLCVIAVDRYFAITSPFKYQSLLTKNKARVIIL--MVWIVSGLTSF------LPIQMHWYRATHQEAINCYAEE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 196 ACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAV-------------------------FRLPSRDA------QHK 244
Cdd:cd15957 156 TCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAkrqlqkidksegrfhnqnidqngsgGGGGNRRRskfclkEHK 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47575941 245 ALSTCGSHLGVILVFYIPAFFSFLTHRFGHNRVPKNVHIFLaNLYVLVPPVLNPIIYgARTKEIR 309
Cdd:cd15957 236 ALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILL-NWIGYVNSGFNPLIY-CRSPDFR 298
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
74-309 2.15e-04

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 42.40  E-value: 2.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  74 LSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQII 153
Cdd:cd15002  43 LSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHACMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITAVVA 122
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 154 FAGIVRSVAIVSPFIFllRRLPYCSHRVMAhtyceHMGIARLACaniTVNIVYGLTVALLAMGLDSILIAISYGFILRAV 233
Cdd:cd15002 123 SIWVPACLLPLPQWLF--RTVKQSEGVYLC-----ILCIPPLAH---EFMSAFVKLYPLFVFCLPLTFALFYFWRAYGQC 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 234 FR--LPSRDAQHKALSTCGSH--LGVILVFYIP-----AFFSFLTHRFGHNRVPKNVHIFLANLYVLVPPVLNPIIYGAR 304
Cdd:cd15002 193 QRrgTKTQNLRNQIRSRKLTHmlLSVVLAFTILwlpewVAWLWLIHIKSSGSSPPQLFNVLAQLLAFSISSVNPIIFLLM 272

                ....*
gi 47575941 305 TKEIR 309
Cdd:cd15002 273 SEEFR 277
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
35-186 2.19e-04

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 42.32  E-value: 2.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  35 IAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWlNANEISFGgclaQMFCVHS 114
Cdd:cd15134   3 ITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIW-QQYPWVFG----EVFCKLR 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 115 IYALE----SSVLLAMAF--DRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLR----RLPYCSHRVMAH 184
Cdd:cd15134  78 AFLSEmssyASVLTITAFsvERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAIQTRivylEYPPTSGEALEE 157

                ..
gi 47575941 185 TY 186
Cdd:cd15134 158 SA 159
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
40-309 2.20e-04

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 42.10  E-value: 2.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  40 CVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkmLAILWLNANEISFGGCLAQMFCVHSIYALE 119
Cdd:cd15063   8 TFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLP--FSAVNEVLDVWIFGHTWCQIWLAVDVWMCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 120 SSV--LLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCehmgiaRLAC 197
Cdd:cd15063  86 ASIlnLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKDGIMDYSGSSSL------PCTC 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 198 AnITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRlpsrdaQHKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNRV 277
Cdd:cd15063 160 E-LTNGRGYVIYSALGSFYIPMLVMLFFYFRIYRAARM------ETKAAKTVAIIVGCFIFCWLPFFTVYLVRAFCEDCI 232
                       250       260       270
                ....*....|....*....|....*....|..
gi 47575941 278 PKNVHIFLANLYVLvPPVLNPIIYGARTKEIR 309
Cdd:cd15063 233 PPLLFSVFFWLGYC-NSALNPCIYALFSRDFR 263
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
35-156 2.36e-04

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 42.05  E-value: 2.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  35 IAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVP----KMLAILWLNANEI-SFGGCLAQM 109
Cdd:cd15317   3 IYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPfsmiRTVETCWYFGDLFcKFHTGLDLL 82
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 47575941 110 FCVHSIYALessvlLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAG 156
Cdd:cd15317  83 LCTTSIFHL-----CFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIG 124
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
41-166 2.45e-04

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 41.85  E-value: 2.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  41 VMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLailwlnANEI----SFGGCLAQMFCVHSIY 116
Cdd:cd15322   9 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSL------ANEVmgywYFGKVWCEIYLALDVL 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47575941 117 ALESSV--LLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSP 166
Cdd:cd15322  83 FCTSSIvhLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFP 134
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
35-310 2.96e-04

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 41.58  E-value: 2.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  35 IAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkmLAILWLNANEISFGGCLAQMFCVHS 114
Cdd:cd15061   2 LISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLP--LAIIRQLLGYWPLGSHLCDFWISLD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 115 IYALESSVL--LAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLlrrlpycshrvmahtyCEHMGI 192
Cdd:cd15061  80 VLLCTASILnlCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVG----------------PSWHGR 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 193 ARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRlpsrdaQHKALSTCGSHLGVILVFYIPAFFSFLTHRF 272
Cdd:cd15061 144 RGLGSCYYTYDKGYRIYSSMGSFFLPLLLMLFVYLRIFRVIAK------ERKTAKTLAIVVGCFIVCWLPFFIMYLIEPF 217
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47575941 273 GHNRVPKNVHIFLANLYVLvPPVLNPIIYGARTKEIRS 310
Cdd:cd15061 218 CDCQFSEALSTAFTWLGYF-NSVINPFIYAFYNKDFRR 254
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
44-163 3.20e-04

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 41.85  E-value: 3.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  44 LIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAI---LWLNANEISFGGCLAQMFCVHSIYALes 120
Cdd:cd15068  12 VLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIstgFCAACHGCLFIACFVLVLTQSSIFSL-- 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 47575941 121 svlLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAI 163
Cdd:cd15068  90 ---LAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAI 129
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
34-166 3.21e-04

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 41.84  E-value: 3.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  34 WIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVP-KMLAILWlnaneiSFGGCLAQMFCV 112
Cdd:cd15304   2 WPALLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILY------GYRWPLPSKLCA 75
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 113 HSIY--ALESSV----LLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSP 166
Cdd:cd15304  76 VWIYldVLFSTAsimhLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMP 135
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
33-139 3.30e-04

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 41.90  E-value: 3.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  33 LWIaIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILwLNANEIsFG--GCLAQMF 110
Cdd:cd15390   2 LWS-IVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYL-LYNDWP-FGlfYCKFSNF 78
                        90       100       110
                ....*....|....*....|....*....|.
gi 47575941 111 CvhSIYALESSV--LLAMAFDRYVAICNPLR 139
Cdd:cd15390  79 V--AITTVAASVftLMAISIDRYIAIVHPLR 107
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
41-235 3.87e-04

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 41.55  E-value: 3.87e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  41 VMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVhSIYALES 120
Cdd:cd15083   9 IIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSG-GLFGIMS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 121 SV-LLAMAFDRYVAICNPLRYTTILNHTViAQIIFAGI-VRSVAIVSPFIFLLRR------LPYCSHRVMAHTycehmgi 192
Cdd:cd15083  88 INtLAAIAVDRYLVITRPMKASVRISHRR-ALIVIAVVwLYSLLWVLPPLFGWSRyvleglLTSCSFDYLSRD------- 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 47575941 193 arlacaniTVNIVYGLTVALLAMGLDSILIAISYGFILRAVFR 235
Cdd:cd15083 160 --------DANRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRR 194
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
39-312 3.93e-04

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 41.32  E-value: 3.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQ--------MF 110
Cdd:cd15351   7 FLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQhmdnvidtMI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 111 CVHSIYALesSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIfllrrlpycshrvmahTYCEHM 190
Cdd:cd15351  87 CSSVVSSL--SFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFI----------------VYYNSN 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 191 GIarLACAnitvnIVYGLTVALLAMGLDSILIAISYGF---ILRAVFRLPS--RDAQHKALSTCGSHLGVILVFYIPAFF 265
Cdd:cd15351 149 AV--ILCL-----IVFFLFMLVLMLVLYIHMFILACRHsqsISSQQRRQCPhqQTASLKGAITLTILLGIFFLCWGPFFL 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 47575941 266 SFL------THRFGhNRVPKNVHIFLAnlYVLVPPVLNPIIYGARTKEIRSRL 312
Cdd:cd15351 222 HLTlivtcpTHPFC-LCYFKYFNLFLI--LIICNSIIDPLIYAFRSQELRKTL 271
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
39-312 4.03e-04

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 41.48  E-value: 4.03e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSsTTVPKMLaILWLNANEISFGGCLAQ-MFCVHSIYA 117
Cdd:cd14982   7 YSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFV-LTLPFRI-YYYLNGGWWPFGDFLCRlTGLLFYINM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 118 LESSVLLA-MAFDRYVAICNPLRYTTILNHTViAQIIFAGI-VRSVAIVSPFIFLLRRlpycSHRVMAHTYC--EHMGIA 193
Cdd:cd14982  85 YGSILFLTcISVDRYLAVVHPLKSRRLRRKRY-AVGVCAGVwILVLVASVPLLLLRST----IAKENNSTTCfeFLSEWL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 194 RLACANITVNIVYGLTVALlamgldsILIAISYGFILRAVFRLPSRDAQH----KALSTCGSHLGVILVFYIP------A 263
Cdd:cd14982 160 ASAAPIVLIALVVGFLIPL-------LIILVCYSLIIRALRRRSKQSQKSvrkrKALRMILIVLAVFLVCFLPyhvtriL 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47575941 264 FFSFLTHRFGHNRVPKNVHIF------LANLYVlvppVLNPIIYGARTKEIRSRL 312
Cdd:cd14982 233 YLLVRLSFIADCSARNSLYKAyritlcLASLNS----CLDPLIYYFLSKTFRKRL 283
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
36-169 5.56e-04

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 40.88  E-value: 5.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  36 AIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkmLAILWLNANEISFGGCLAQMFCVHSI 115
Cdd:cd15060   4 TILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLP--LNVAYFLLGKWLFGIHLCQMWLTCDI 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47575941 116 YALESSVL--LAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIF 169
Cdd:cd15060  82 LCCTASILnlCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLI 137
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
33-167 5.86e-04

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 41.11  E-value: 5.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  33 LWIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkmLAILWLNANEISFG--GCLAQMF 110
Cdd:cd15074   1 IIIGIYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYP--LAIISAFAHRWLFGdiGCVFYGF 78
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 47575941 111 CVHsIYALES-SVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPF 167
Cdd:cd15074  79 CGF-LFGCCSiNTLTAISIYRYLKICHPPYGPKLSRRHVCIVIVAIWLYALFWAVAPL 135
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
41-169 6.31e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 40.90  E-value: 6.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  41 VMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVP-KMLAILWLNANEISFGGC-----LAQMFCVHS 114
Cdd:cd15005   9 LILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPfVMASVRHGSGWIYGALSCkviafLAVLFCFHS 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47575941 115 IYalessVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIF 169
Cdd:cd15005  89 AF-----TLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVF 138
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
35-139 6.33e-04

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 40.71  E-value: 6.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  35 IAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDlALSSTTVPKMLAILWLNAneISFGGCLAQMFCVHS 114
Cdd:cd15091   3 ITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALAD-ALVTTTMPFQSTVYLMNS--WPFGDVLCKIVISID 79
                        90       100
                ....*....|....*....|....*..
gi 47575941 115 IYALESSV--LLAMAFDRYVAICNPLR 139
Cdd:cd15091  80 YYNMFTSIftLTMMSVDRYIAVCHPVK 106
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
39-235 7.00e-04

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 40.57  E-value: 7.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15979   7 YSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVSV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPF--IFLLRRLPYCSHRVMahtyceHMgiARLA 196
Cdd:cd15979  87 STFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYpvYSVTVPVPVGDRPRG------HQ--CRHA 158
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 47575941 197 CANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFR 235
Cdd:cd15979 159 WPSAQVRQAWYVLLLLILFFIPGVVMIVAYGLISRELYR 197
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
34-155 7.03e-04

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 40.65  E-value: 7.03e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  34 WIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFcVH 113
Cdd:cd14969   2 VLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGF-AV 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 47575941 114 SIYALESSVLLA-MAFDRYVAICNPLRYTTILNHTVIAQIIFA 155
Cdd:cd14969  81 TFLGLVSISTLAaLAFERYLVIVRPLKAFRLSKRRALILIAFI 123
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
41-235 7.08e-04

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 40.69  E-value: 7.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  41 VMYLIALLGNAaLILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLA-ILWLNANEISFGGCLAQMFCVH--SIYA 117
Cdd:cd14978   9 VICIFGIIGNI-LNLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLpYIADYSSSFLSYFYAYFLPYIYplANTF 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 118 LESSVLL--AMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMAHTYCEHMGIARL 195
Cdd:cd14978  88 QTASVWLtvALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTLLRQN 167
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 47575941 196 ACANITV-NIVYGLTVALLAMgldsILIAISYGFILRAVFR 235
Cdd:cd14978 168 ETYLLKYyFWLYAIFVVLLPF----ILLLILNILLIRALRK 204
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
34-309 7.80e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 40.66  E-value: 7.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  34 WIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVP-KMLAILWLNANEISFGGC-----LA 107
Cdd:cd15305   2 WPALLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPvSLIAILYDYAWPLPRYLCpiwisLD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 108 QMFCVHSIYAlessvLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRlpyCSHRVMAHTYC 187
Cdd:cd15305  82 VLFSTASIMH-----LCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMPIPVIGLQ---DDEKVFVNGTC 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 188 ehmgiarlacanITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALSTCGSHLGVILVFYIPAFFSF 267
Cdd:cd15305 154 ------------VLNDENFVLIGSFVAFFIPLIIMVITYCLTIQVLQRQQAINNERRASKVLGIVFFLFLIMWCPFFITN 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 47575941 268 LTHRFGHNRVPKNVHIFLANLYVLVPPV---LNPIIYGARTKEIR 309
Cdd:cd15305 222 ILSVLCKEACDQKLMEELLNVFVWVGYVssgINPLVYTLFNKTYR 266
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
35-140 9.01e-04

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 40.29  E-value: 9.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  35 IAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLailwlnANEI----SFGGCLAQMF 110
Cdd:cd15321   9 IAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSL------ANELmgywYFRKTWCEIY 82
                        90       100       110
                ....*....|....*....|....*....|..
gi 47575941 111 CVHSIYALESSV--LLAMAFDRYVAICNPLRY 140
Cdd:cd15321  83 LALDVLFCTSSIvhLCAISLDRYWSVSRAIEY 114
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
39-303 1.00e-03

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 40.10  E-value: 1.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSsttVPKMLAILWLNANEISFGGcLAQMFCVHSI--Y 116
Cdd:cd14964   5 LSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLAS---LVVLVLFFLLGLTEASSRP-QALCYLIYLLwyG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 117 ALESSV--LLAMAFDRYVAICNPLRYTTilnhtviaQIIFAGIVRSVAIVSPFIFLLRRLPYCSHRVMaHTYCEHMGIAR 194
Cdd:cd14964  81 ANLASIwtTLVLTYHRYFALCGPLKYTR--------LSSPGKTRVIILGCWGVSLLLSIPPLVGKGAI-PRYNTLTGSCY 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 LACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSR-----DAQHKALSTCGSHLGVILVFYIPAFFSFLT 269
Cdd:cd14964 152 LICTTIYLTWGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAaslntDKNLKATKSLLILVITFLLCWLPFSIVFIL 231
                       250       260       270
                ....*....|....*....|....*....|....
gi 47575941 270 HRFGHNRVPKNVHIFLANLYVLVPPVLNPIIYGA 303
Cdd:cd14964 232 HALVAAGQGLNLLSILANLLAVLASTLNPFIYCL 265
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
41-172 1.15e-03

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 40.15  E-value: 1.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  41 VMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkmLAILWLNANEISFGGCLAQMFCVHSIYALES 120
Cdd:cd15205   9 LIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIP--FTLLQNISSNWLGGAFMCKMVPFVQSTAVVT 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 47575941 121 SVLLAM--AFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLR 172
Cdd:cd15205  87 SILTMTciAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQQ 140
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
35-176 1.17e-03

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 39.97  E-value: 1.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  35 IAIP--FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDlALSSTTVPKMLAILWLNanEISFGGCLAQMFCV 112
Cdd:cd14970   1 IVIPavYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVAD-ELFLLGLPFLATSYLLG--YWPFGEVMCKIVLS 77
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47575941 113 HSIYALESSV--LLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPY 176
Cdd:cd14970  78 VDAYNMFTSIfcLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQE 143
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
35-144 1.58e-03

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 39.49  E-value: 1.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  35 IAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkmLAILWLNANEISFGGCLAQMFCVHS 114
Cdd:cd15325   3 LGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLP--FSAIFEILGYWAFGRVFCNIWAAVD 80
                        90       100       110
                ....*....|....*....|....*....|..
gi 47575941 115 IYALESSV--LLAMAFDRYVAICNPLRYTTIL 144
Cdd:cd15325  81 VLCCTASImsLCIISIDRYIGVSYPLRYPSIM 112
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
35-165 1.82e-03

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 39.48  E-value: 1.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  35 IAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLaLSSTTVPKMLAILWlNANEISFGGCLAQMFCVHS 114
Cdd:cd15131   3 ITVTCVLLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDL-LIFLCMPLDLYRLW-QYRPWNFGDLLCKLFQFVS 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 47575941 115 IYALESSVL--LAMAFDRYVAICNPLRYTTILNHTVIAQIIFagIVRSVAIVS 165
Cdd:cd15131  81 ESCTYSTILniTALSVERYFAICFPLRAKVVVTKRRVKLVIL--VLWAVSFLS 131
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
35-248 1.93e-03

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 39.26  E-value: 1.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  35 IAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWlNANEISFG--GCLAQMFCV 112
Cdd:cd14979   3 VTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFW-WQYPWAFGdgGCKLYYFLF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 113 HSIYALESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLpycSHRVMAHTYCEHMGI 192
Cdd:cd14979  82 EACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQ---YLNGPLPGPVPDSAV 158
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47575941 193 ARLACANITVNIVYGlTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALST 248
Cdd:cd14979 159 CTLVVDRSTFKYVFQ-VSTFIFFVLPMFVISILYFRIGVKLRSMRNIKKGTRAQGT 213
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
45-169 2.51e-03

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 39.16  E-value: 2.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  45 IALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAIL-----W----LNANEISFggcLAQMFCVHSI 115
Cdd:cd15217  13 VSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIrngsaWtysvLSCKIVAF---MAVLFCFHAA 89
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 47575941 116 YalessVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIF 169
Cdd:cd15217  90 F-----MLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVF 138
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
37-312 2.85e-03

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 38.72  E-value: 2.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  37 IPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFggCLAQMFcvhsIY 116
Cdd:cd15960   5 IALCVTGTVMACENAIVIAILFYTPSLRAPMFILIGSLALADLLAGLGLIANFVAIYVMNSEAVTL--CSAGLL----LA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 117 ALESSV--LLAMAFDRYVAICNPLRYttilnHTVIAQIIFAGIVRSVAIVSPFIFLLRRLPYcsHRVMAHTYCEhmgiar 194
Cdd:cd15960  79 AFSASVcsLLAITVDRYLSLYNALTY-----HTERTLTFTYGLLALLWLTCIGIGLLPAMGW--NCLRAPASCS------ 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 195 lACANITVNIVYGLTVALLamgLDSILIAISYGFILRAVFRLPSRDA-QHKALSTC---GSHLGVILVFYIPAFFSFLTH 270
Cdd:cd15960 146 -VLRPVTKNNAAVLAVSFL---LLFALMMQLYLQICRIAFRHAQQIAvQHQFVNFClasSTRKGVSTLSLILATFAFCWV 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 47575941 271 RFGHNRVPKNVHIFLANLYVLVPP-----VLNPIIYGARTKEIRSRL 312
Cdd:cd15960 222 PFAVYSMVADSSYPMIYTYYLVLPaacnsVINPIIYAFRNPDIQKSL 268
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
34-170 3.12e-03

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 38.45  E-value: 3.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  34 WIAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVP-KMLAILWLNANEISFGGCLAQ---- 108
Cdd:cd15052   2 WAALLLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWvtld 81
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47575941 109 -MFCVHSIYAlessvLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFL 170
Cdd:cd15052  82 vLFCTASIMH-----LCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVL 139
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
35-309 3.76e-03

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 38.49  E-value: 3.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  35 IAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSttvpkmLAILWLNANEI----SFGGCLAQ-- 108
Cdd:cd15065   2 IGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVAL------LVMTFAVVNDLlgywLFGETFCNiw 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 109 -----MFCVHSIYAlessvLLAMAFDRYVAICNPLRYTTILNHTViaqiIFAGIVrSVAIVSPFI-FLLRRLPYCSHRVM 182
Cdd:cd15065  76 isfdvMCSTASILN-----LCAISLDRYIHIKKPLKYERWMTTRR----ALVVIA-SVWILSALIsFLPIHLGWHRLSQD 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 183 AHTYCEHMGIARLACAnITVNIVYGLTVALLAMGLDSILIAISYGFILRAV-------------------FRLPSRDAQ- 242
Cdd:cd15065 146 EIKGLNHASNPKPSCA-LDLNPTYAVVSSLISFYIPCLVMLLIYSRLYLYArkhvvniksqklpsesgskFQVPSLSSKh 224
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47575941 243 -------HKALSTCGSHLGVILVFYIPAFFSFLTHRFGHNRVPKNVHIFLANL-YvlVPPVLNPIIYGARTKEIR 309
Cdd:cd15065 225 nnqgvsdHKAAVTLGIIMGVFLICWLPFFIINIIAAFCKTCIPPKCFKILTWLgY--FNSCLNPIIYSIFNSEFR 297
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
35-309 4.21e-03

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 38.24  E-value: 4.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  35 IAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkMLAILWLNANeISFGGCLAQMFCVHS 114
Cdd:cd15062   3 VGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLP-FSATLEVLGY-WAFGRIFCDVWAAVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 115 IYALESSV--LLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAI-VSPFIFLLRRLPycshrvmahtycehmg 191
Cdd:cd15062  81 VLCCTASImsLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVIsIGPLLGWKEPAP---------------- 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 192 iARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLpSRdaQHKALSTCGSHLGVILVFYIPAFFSFLTHR 271
Cdd:cd15062 145 -ADEQACGVNEEPGYVLFSSLGSFYLPLAIILVMYCRVYVVAFKF-SR--EKKAAKTLGIVVGAFVLCWFPFFVVLPLGS 220
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47575941 272 FGHNRVPKNVHIFLANLYVLVPPVLNPIIYGARTKEIR 309
Cdd:cd15062 221 LFSTLKPPEPVFKVVFWLGYFNSCLNPIIYPCSSREFK 258
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
39-167 4.79e-03

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 37.93  E-value: 4.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGGCLAQMFCVHSIYAL 118
Cdd:cd15978   7 YSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSV 86
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47575941 119 ESSVLLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPF 167
Cdd:cd15978  87 STFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPY 135
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
35-139 7.08e-03

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 37.63  E-value: 7.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  35 IAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNanEISFGGCLaqmfCVHS 114
Cdd:cd15927   3 VPILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLD--SWPFGEFL----CKLS 76
                        90       100       110
                ....*....|....*....|....*....|.
gi 47575941 115 IYALESSV------LLAMAFDRYVAICNPLR 139
Cdd:cd15927  77 EFLKDTSIgvsvftLTALSADRYFAIVNPMR 107
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
39-144 7.19e-03

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 37.45  E-value: 7.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLNANEISFGG--------CLAQMF 110
Cdd:cd15350   7 FFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADMGYLNRRGpfetklddIMDSLF 86
                        90       100       110
                ....*....|....*....|....*....|....
gi 47575941 111 CVHSIYALESsvLLAMAFDRYVAICNPLRYTTIL 144
Cdd:cd15350  87 CLSLLGSIFS--ILAIAADRYITIFHALRYHNIM 118
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
41-175 7.21e-03

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 37.51  E-value: 7.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  41 VMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVP-----KMLAILWLnaneISFGGCLAQM-----F 110
Cdd:cd15308   9 LLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPlyvysEFQGGVWT----LSPVLCDALMtmdvmL 84
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47575941 111 CVHSIYALessvlLAMAFDRYVAICNPLRYTTILNHTVIAQIIFAGIVRSVAIVSPFIFLLRRLP 175
Cdd:cd15308  85 CTASIFNL-----CAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLNNVP 144
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
35-140 7.78e-03

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 37.54  E-value: 7.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  35 IAIPFCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLA-----ILWLNANEISFGGCLAQM 109
Cdd:cd15324   3 IVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLAnevmgYWYFGSTWCAFYLALDVL 82
                        90       100       110
                ....*....|....*....|....*....|.
gi 47575941 110 FCVHSIYAlessvLLAMAFDRYVAICNPLRY 140
Cdd:cd15324  83 FCTSSIVH-----LCAISLDRYWSVTKAVSY 108
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
39-248 8.79e-03

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 37.26  E-value: 8.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  39 FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPkMLAILWLNANEIsFGgclaQMFCVHSIYAL 118
Cdd:cd15095   7 FAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVP-FTAALYATPSWV-FG----DFMCKFVNYMM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941 119 ESSV------LLAMAFDRYVAICNPLR---YTTILNHTVIAQIIFAGivrSVAIVSPFIFLLRRLPYCSHRVmaHTYCEH 189
Cdd:cd15095  81 QVTVqatcltLTALSVDRYYAIVHPIRslrFRTPRVAVVVSACIWIV---SFLLSIPVAIYYRLEEGYWYGP--QTYCRE 155
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47575941 190 MgiarlaCANITVNIVYGLTVALLAMGLDSILIAISYGFILRAVFRLPSRDAQHKALST 248
Cdd:cd15095 156 V------WPSKAFQKAYMIYTVLLTYVIPLAIIAVCYGLILRRLWRRSVDGNNQSEQLS 208
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
37-139 9.18e-03

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 37.41  E-value: 9.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47575941  37 IP-FCVMYLIALLGNAALILIIGTESALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWlnaneiSFGGCLAQMFCVHSI 115
Cdd:cd15394   4 IPlYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAF------EPRGWVFGRFMCYFV 77
                        90       100       110
                ....*....|....*....|....*....|.
gi 47575941 116 YALESSV-------LLAMAFDRYVAICNPLR 139
Cdd:cd15394  78 FLMQPVTvyvsvftLTAIAVDRYYVTVYPLR 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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