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Conserved domains on  [gi|47577687|ref|NP_001000542|]
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olfactory receptor Olr63 [Rattus norvegicus]

Protein Classification

olfactory receptor family 51 protein( domain architecture ID 11607012)

olfactory receptor family 51 protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
27-300 4.74e-167

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320350  Cd Length: 275  Bit Score: 465.05  E-value: 4.74e-167
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  27 FWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAI 106
Cdd:cd15222   1 HWISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 107 HSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDV 186
Cdd:cd15222  81 HTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 187 MKLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRF 265
Cdd:cd15222 161 MKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIaSREERLKALNTCVSHICAVLIFYVPMIGLSMVHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577687 266 SKRHDSLLPVIMANIYLLVPPVLNPIVYGVKTKEI 300
Cdd:cd15222 241 GKHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
 
Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
27-300 4.74e-167

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 465.05  E-value: 4.74e-167
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  27 FWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAI 106
Cdd:cd15222   1 HWISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 107 HSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDV 186
Cdd:cd15222  81 HTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 187 MKLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRF 265
Cdd:cd15222 161 MKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIaSREERLKALNTCVSHICAVLIFYVPMIGLSMVHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577687 266 SKRHDSLLPVIMANIYLLVPPVLNPIVYGVKTKEI 300
Cdd:cd15222 241 GKHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
33-309 1.55e-107

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 314.44  E-value: 1.55e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687    33 LCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGM 112
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687   113 ESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACA 192
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687   193 DIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRFSKRHDS 271
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIaSREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPP 240
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 47577687   272 LLPVIMANIYLLVPPVLNPIVYGVKTKEIRQRILRLFL 309
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278
 
Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
27-300 4.74e-167

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 465.05  E-value: 4.74e-167
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  27 FWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAI 106
Cdd:cd15222   1 HWISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 107 HSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDV 186
Cdd:cd15222  81 HTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 187 MKLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRF 265
Cdd:cd15222 161 MKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIaSREERLKALNTCVSHICAVLIFYVPMIGLSMVHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577687 266 SKRHDSLLPVIMANIYLLVPPVLNPIVYGVKTKEI 300
Cdd:cd15222 241 GKHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
27-300 6.25e-131

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 373.55  E-value: 6.25e-131
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  27 FWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAI 106
Cdd:cd15917   1 IWLSIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 107 HSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDV 186
Cdd:cd15917  81 HSFTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 187 MKLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRF 265
Cdd:cd15917 161 VKLACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLpSKEARLKALSTCGSHICVILIFYTPALFSFLTHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577687 266 SKRHDSLLPVIMANIYLLVPPVLNPIVYGVKTKEI 300
Cdd:cd15917 241 GHHVPPHVHILLANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
27-300 4.09e-124

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 356.27  E-value: 4.09e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  27 FWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAI 106
Cdd:cd15951   1 VWISIPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 107 HSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDV 186
Cdd:cd15951  81 HSFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 187 MKLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRF 265
Cdd:cd15951 161 VKLACADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLpSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577687 266 SKRHDSLLPVIMANIYLLVPPVLNPIVYGVKTKEI 300
Cdd:cd15951 241 GHNVPPHVHILIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
27-300 1.69e-120

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 347.36  E-value: 1.69e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  27 FWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAI 106
Cdd:cd15221   1 VWISIPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 107 HSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDV 186
Cdd:cd15221  81 HFVFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 187 MKLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRF 265
Cdd:cd15221 161 ARLACADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLpSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577687 266 SKRHDSLLPVIMANIYLLVPPVLNPIVYGVKTKEI 300
Cdd:cd15221 241 GRHIPRHVHILLANLYVLVPPMLNPIVYGVKTKQI 275
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
27-300 2.58e-119

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 344.25  E-value: 2.58e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  27 FWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAI 106
Cdd:cd15953   1 IWISIPFCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 107 HSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDV 186
Cdd:cd15953  81 HTLSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 187 MKLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGLT-REAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRF 265
Cdd:cd15953 161 VKLACGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSsKKARQKALNTCTAHICVILMSYTPALFSFLTHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577687 266 SKRHDSLLPVIMANIYLLVPPVLNPIVYGVKTKEI 300
Cdd:cd15953 241 GQGIAPHIHIILANLYLLVPPMLNPIIYGVKTKEI 275
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
27-300 2.30e-115

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 334.38  E-value: 2.30e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  27 FWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAI 106
Cdd:cd15950   1 FWIAIPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 107 HSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDV 186
Cdd:cd15950  81 HSFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 187 MKLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRF 265
Cdd:cd15950 161 VKLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLsSKEARLKAFSTCGSHVCVILLFYIPGLLSIYTQRF 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577687 266 SKRHDSLLPVIMANIYLLVPPVLNPIVYGVKTKEI 300
Cdd:cd15950 241 GQGVPPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
12-301 6.14e-111

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 323.65  E-value: 6.14e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  12 TYFILIGLPGLEEFQFWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNS 91
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  92 TTIQFDACLIQMFAIHSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFC 171
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 172 RSNILSHSYCLHQDVMKLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVF 250
Cdd:cd15949 162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLaTSEARLKTFGTCVSHVCAIL 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 47577687 251 IFYVPFIGLSMVHRFSKRHDSLLPVIMANIYLLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15949 242 AFYVPIAVSSLIHRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
28-301 2.84e-109

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 318.77  E-value: 2.84e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  28 WLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIH 107
Cdd:cd15948   3 WISIPFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLH 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 108 SLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVM 187
Cdd:cd15948  83 SFSIMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 188 KLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRFS 266
Cdd:cd15948 163 KLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLaSKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHRFA 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577687 267 KRHDSLLPVIMANIYLLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15948 243 RHVAPHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
27-300 5.38e-109

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 318.17  E-value: 5.38e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  27 FWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAI 106
Cdd:cd15952   1 FWIGFPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 107 HSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDV 186
Cdd:cd15952  81 HTFTGMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 187 MKLACADIRVNIIYGLIViISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRF 265
Cdd:cd15952 161 AKLACASIRINIIYGLFA-ISVLVLDVILIALSYVLILRAVFRLpSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRF 239
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577687 266 SKRHDSLLPVIMANIYLLVPPVLNPIVYGVKTKEI 300
Cdd:cd15952 240 GHNIPRYIHILLANLYVVLPPMLNPVIYGVRTKQI 274
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
33-309 1.55e-107

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 314.44  E-value: 1.55e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687    33 LCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGM 112
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687   113 ESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACA 192
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687   193 DIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRFSKRHDS 271
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIaSREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPP 240
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 47577687   272 LLPVIMANIYLLVPPVLNPIVYGVKTKEIRQRILRLFL 309
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
28-304 5.75e-105

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 308.07  E-value: 5.75e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  28 WLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIH 107
Cdd:cd15223   2 WLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 108 SLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVM 187
Cdd:cd15223  82 FFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 188 KLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRFS 266
Cdd:cd15223 162 SLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLaSGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFG 241
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47577687 267 KRHDSLLPVIMANIYLLVPPVLNPIVYGVKTKEIRQRI 304
Cdd:cd15223 242 KTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
28-300 2.38e-97

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 288.65  E-value: 2.38e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  28 WLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIH 107
Cdd:cd15954   2 WISIPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 108 SLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVM 187
Cdd:cd15954  82 TFTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 188 KLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRFS 266
Cdd:cd15954 162 KLACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLsSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRFG 241
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577687 267 KRH-DSLLPVIMANIYLLVPPVLNPIVYGVKTKEI 300
Cdd:cd15954 242 GHHiTPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
28-300 1.85e-93

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 278.67  E-value: 1.85e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  28 WLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIH 107
Cdd:cd15956   2 WLSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 108 SLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVM 187
Cdd:cd15956  82 AFSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 188 KLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRFS 266
Cdd:cd15956 162 KLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLpSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFG 241
                       250       260       270
                ....*....|....*....|....*....|....
gi 47577687 267 KRHDSLLPVIMANIYLLVPPVLNPIVYGVKTKEI 300
Cdd:cd15956 242 HSVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
27-300 2.76e-92

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 275.49  E-value: 2.76e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  27 FWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAI 106
Cdd:cd15955   1 HWIGIPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 107 HSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIK-RLPFCRSNILSHSYCLHQD 185
Cdd:cd15955  81 HTLQAFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIKlRLHHFRSTVISHSYCEHMA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 186 VMKLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHR 264
Cdd:cd15955 161 VVKLAADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLpQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHR 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577687 265 FSKRHDSLLPVIMANIYLLVPPVLNPIVYGVKTKEI 300
Cdd:cd15955 241 FGHHVAPYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
27-293 2.98e-77

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 237.00  E-value: 2.98e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  27 FWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAI 106
Cdd:cd13954   1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 107 HSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDV 186
Cdd:cd13954  81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 187 MKLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMvhRF 265
Cdd:cd13954 161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIpSAEGRQKAFSTCASHLTVVSLFYGTIIFMYV--RP 238
                       250       260
                ....*....|....*....|....*...
gi 47577687 266 SKRHDSLLPVIMANIYLLVPPVLNPIVY 293
Cdd:cd13954 239 SSSYSSDLDKVVSVFYTVVTPMLNPIIY 266
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
36-301 5.28e-61

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 195.75  E-value: 5.28e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15225  10 IYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTECF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIR 195
Cdd:cd15225  90 LLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACADTS 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 196 VNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFY--VPFIGLSMVHRFSKRHDSL 272
Cdd:cd15225 170 LNEIAIFVASVLVILVPFLLILVSYIFIISTILKIpSAEGRRKAFSTCSSHLIVVTLFYgcASFTYLRPKSSYSPETDKL 249
                       250       260
                ....*....|....*....|....*....
gi 47577687 273 LPVimanIYLLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15225 250 LSL----FYTVVTPMLNPIIYSLRNKEVK 274
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
29-293 1.97e-55

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 181.14  E-value: 1.97e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  29 LAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHS 108
Cdd:cd15912   3 LFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 109 LSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMK 188
Cdd:cd15912  83 LGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 189 LACADIR----VNIIYGLIVIISAIgldsLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMvh 263
Cdd:cd15912 163 LSCSDTRlielLDFILASVVLLGSL----LLTIVSYIYIISTILRIpSASGRQKAFSTCASHLTVVSIFYGSCIFMYV-- 236
                       250       260       270
                ....*....|....*....|....*....|
gi 47577687 264 RFSKRHDSLLPVIMANIYLLVPPVLNPIVY 293
Cdd:cd15912 237 RPSQSSSLDLNKVVALLNTVVTPLLNPFIY 266
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
36-306 2.81e-55

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 180.98  E-value: 2.81e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15411  10 IYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTlpRVAKIGMAAVVRGAALMAPL--PVFIKRLPFCRSNILSHSYCLHQDVMKLACAD 193
Cdd:cd15411  90 LLGLMAYDRYVAICNPLLYTVVMS--RRVCLKLAAGSYAAGFLNSLihTTLISRLSFCGSNVINHFFCDTPPLLKLSCSD 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 194 IRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVP--FIGLSMVHRFSKRHD 270
Cdd:cd15411 168 THVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIrSAEGRRKAFSTCASHLTAVTIFYGTgiFTYLRPSSSYSLGQD 247
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577687 271 SLLPVimanIYLLVPPVLNPIVYGVKTKEIRQRILR 306
Cdd:cd15411 248 KVASV----FYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
29-293 8.66e-55

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 179.39  E-value: 8.66e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  29 LAFPLCSL-YLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIH 107
Cdd:cd15237   2 LLFILFLLiYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 108 SLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVM 187
Cdd:cd15237  82 ALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 188 KLACADIRVN--IIYGLIVIIsaIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMV-- 262
Cdd:cd15237 162 KLACADTSLNeaVIFVTSVLV--LLIPFSLILASYIRILATILRIqSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRph 239
                       250       260       270
                ....*....|....*....|....*....|.
gi 47577687 263 HRFSKRHDSLLPVimanIYLLVPPVLNPIVY 293
Cdd:cd15237 240 STHSPDQDKMISV----FYTIVTPMLNPLIY 266
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
14-301 5.21e-54

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 177.90  E-value: 5.21e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  14 FILIGLPGLEEFQFWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTT 93
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  94 IQFDACLIQMFAIHSLSGMESTVLLAMAFDRYVAICHPLRHATVLTlPRVAkIGMAAVVRGAALMAPL--PVFIKRLPFC 171
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMS-QRVC-VSLVAGSYLAGFLNSTvhTGFILRLSFC 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 172 RSNILSHSYCLHQDVMKLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVF 250
Cdd:cd15408 159 GSNVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMrSAEGRHKAFSTCASHLTAVT 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 47577687 251 IFY--VPFIGLSMVHRFSKRHDSLLPVimanIYLLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15408 239 LFYgsLAFMYLRPSSRYSLDLDKVASV----FYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
37-293 1.61e-53

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 176.16  E-value: 1.61e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  37 YLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMESTV 116
Cdd:cd15230  11 YLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 117 LLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIRV 196
Cdd:cd15230  91 LAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCSDTHI 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 197 NIIYgLIVIISAIGLDS-LFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFY--VPFIGLSMVHRFSKRHDSL 272
Cdd:cd15230 171 NELV-LFAFSGFIGLSTlLIILISYLYILITILRIrSAEGRRKAFSTCASHLTAVSLFYgtLIFMYLRPSSSYSLDQDKV 249
                       250       260
                ....*....|....*....|.
gi 47577687 273 LPVimanIYLLVPPVLNPIVY 293
Cdd:cd15230 250 VSV----FYTVVIPMLNPLIY 266
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
36-293 2.34e-53

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 175.88  E-value: 2.34e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15431  10 VYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITECL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTlpRVAKIGMAAVVRGAA-LMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADI 194
Cdd:cd15431  90 LLAVMAYDRFVAICNPLRYTLIMS--WRVCIQLAAGSWVSAfLLTVIPVLTMPLHFCGPNVINHFFCEVQALLKLACSDT 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 195 RVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVP--FIGLSMVHRFSKRHDS 271
Cdd:cd15431 168 SLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIrSAEGRRKAFSTCGSHLTVVTIFYGTaiFMYLRPQSKSSSDQDK 247
                       250       260
                ....*....|....*....|..
gi 47577687 272 LLPVimanIYLLVPPVLNPIVY 293
Cdd:cd15431 248 IISV----FYGVVTPMLNPLIY 265
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
36-300 8.85e-53

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 174.28  E-value: 8.85e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15421  10 IFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGAECL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHaTVLTLPRVAkIGMAAV--VRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACAD 193
Cdd:cd15421  90 LLALMAYDRYVAICHPLRY-PVLMSPRVC-LLMAAGswLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLSCAD 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 194 IRVniiYGLIVIISAIG---LDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMvhRFSKRH 269
Cdd:cd15421 168 TSA---YETVVYVSGVLfllIPFSLILASYALILLTVLRMrSAEGRKKALATCSSHLTVVSLYYGPAIFTYM--RPGSYH 242
                       250       260       270
                ....*....|....*....|....*....|.
gi 47577687 270 DSLLPVIMANIYLLVPPVLNPIVYGVKTKEI 300
Cdd:cd15421 243 SPEQDKVVSVFYTILTPMLNPLIYSLRNKEV 273
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
28-296 1.25e-52

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 173.71  E-value: 1.25e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  28 WLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIH 107
Cdd:cd15914   2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 108 SLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVM 187
Cdd:cd15914  82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 188 KLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIglSMVHRFS 266
Cdd:cd15914 162 SLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIpSAEGRQKAFSTCAAHLTVVLLFFGSVS--FMYLRLS 239
                       250       260       270
                ....*....|....*....|....*....|
gi 47577687 267 KRHDSLLPVIMANIYLLVPPVLNPIVYGVK 296
Cdd:cd15914 240 KSYSLDYDRAIAVVYAVLTPFFNPIIYSLR 269
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
35-293 2.52e-52

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 173.18  E-value: 2.52e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  35 SLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMES 114
Cdd:cd15918   9 GMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDN 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 115 TVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADI 194
Cdd:cd15918  89 FLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 195 RVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIG--LSMVHRFSKRHDS 271
Cdd:cd15918 169 HLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIpSAGGKWKAFSTCGSHLSVVSLFYGTVIGvyLSPPSSHSASKDS 248
                       250       260
                ....*....|....*....|..
gi 47577687 272 LLPVimanIYLLVPPVLNPIVY 293
Cdd:cd15918 249 VAAV----MYTVVTPMLNPFIY 266
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
31-293 2.89e-52

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 172.94  E-value: 2.89e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  31 FPLCSL-YLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSL 109
Cdd:cd15430   4 FVLCLImYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 110 SGMESTVLLAMAFDRYVAICHPLRHATVLTlpRVAKIGMAAVVRGAALMAPL--PVFIKRLPFCRSNILSHSYCLHQDVM 187
Cdd:cd15430  84 GSTECVLLAVMAYDRYVAICNPLRYPIIMN--KRLCVQMAAGSWVTGFLNSLveTVLAMQLPFCGNNVINHFTCEILAVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 188 KLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGLTR-EAQAKAFGTCVSHVCAVFIFYVPFigLSMVHRFS 266
Cdd:cd15430 162 KLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSaEGRKKAFSTCSAHLTVVIIFYGTI--LFMYMKPK 239
                       250       260
                ....*....|....*....|....*..
gi 47577687 267 KRHDSLLPVIMANIYLLVPPVLNPIVY 293
Cdd:cd15430 240 SKNAQISDKLITLFYGVVTPMLNPIIY 266
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
35-302 4.28e-52

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 172.79  E-value: 4.28e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  35 SLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMES 114
Cdd:cd15235  10 AMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 115 TVLLAMAFDRYVAICHPLRHATVLTLPR-VAKIGMAAVVrgAALMAPLPVF-IKRLPFCRSNILSHSYCLHQDVMKLACA 192
Cdd:cd15235  90 FLLAVMAYDRYVAICHPLHYATVMSPKRcLLLVAGSWLL--SHLHSLLHTLlMSRLSFCGSNEIPHFFCDLQPLLKLSCS 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 193 DIRVNIIY----GLIVIISAIgldsLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSM--VHRF 265
Cdd:cd15235 168 DTSLNELLifteGAVVVLGPF----LLIVLSYARILAAVLKVpSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFqpSSSY 243
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577687 266 SKRHDSLLPVimanIYLLVPPVLNPIVYGVKTKEIRQ 302
Cdd:cd15235 244 SADKDRVATV----MYTVVTPMLNPFIYSLRNKDVKG 276
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
37-301 2.56e-51

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 170.52  E-value: 2.56e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  37 YLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMESTV 116
Cdd:cd15231  11 YLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTECLL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 117 LLAMAFDRYVAICHPLRHATVLTlpRVAKIGMAAVVRGAALMAPL--PVFIKRLPFCRSNILSHSYCLHQDVMKLACADI 194
Cdd:cd15231  91 LAVMAYDRYVAICNPLHYAVIMS--RKVCLQLAAASWLCGFLNSAvhTVLTFRLSFCGSNQISHFFCDIPPLLKLSCSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 195 RVNIIygLIVIISA-IGLD-SLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVP----FIGLSMVHRFSK 267
Cdd:cd15231 169 SLNEV--LLLVASVfIGLTpFLFIVISYVYIISTILKIrSAEGRRKAFSTCASHLTVVTLFYGTaifnYNRPSSGYSLDK 246
                       250       260       270
                ....*....|....*....|....*....|....
gi 47577687 268 rhDSLLPVimanIYLLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15231 247 --DTLISV----LYSIVTPMLNPIIYSLRNKEVK 274
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
36-306 5.93e-51

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 169.89  E-value: 5.93e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15412  10 IYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEYY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGA--ALMAPLPVFikRLPFCRSNILSHSYCLHQDVMKLACAD 193
Cdd:cd15412  90 MLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFlnGLIQTILTF--RLSFCGSNVINHFYCADPPLIKLSCSD 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 194 IRVNIIYglIVIISAIGLDS--LFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIglSMVHRFSKRHD 270
Cdd:cd15412 168 TYVKETA--MFIVAGFNLSSslLIILISYLFILIAILRIrSAEGRCKAFSTCGSHLTAVTIFYGTLF--CMYLRPPSEES 243
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577687 271 SLLPVIMANIYLLVPPVLNPIVYGVKTKEIRQRILR 306
Cdd:cd15412 244 VEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
36-293 6.25e-51

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 169.56  E-value: 6.25e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDI-LISTSsMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMES 114
Cdd:cd15227  10 IYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLcYISVT-VPKSIANSLTNTRSISFLGCVAQVFLFIFFAASEL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 115 TVLLAMAFDRYVAICHPLRHATVLTlpRVAKIGMAAVV-RGAALMAPL-PVFIKRLPFCRSNILSHSYCLHQDVMKLACA 192
Cdd:cd15227  89 ALLTVMAYDRYVAICHPLHYEVIMN--RGACVQMAAASwLSGLLYGALhTANTFSLPFCGSNVIHQFFCDIPQLLKLSCS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 193 DIRVNIIyGLIVIISAIGLDSL-FISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYvpFIGLSMVHRFSKRHD 270
Cdd:cd15227 167 DTYLNEI-GVLVLSVCLGLGCFvFIIVSYVHIFSTVLRIpSAQGRSKAFSTCLPHLIVVSLFL--STGSFAYLKPPSDSP 243
                       250       260
                ....*....|....*....|...
gi 47577687 271 SLLPVIMANIYLLVPPVLNPIVY 293
Cdd:cd15227 244 SLLDLLLSVFYSVVPPTLNPIIY 266
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
14-308 2.65e-50

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 168.70  E-value: 2.65e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  14 FILIGLPGLEEFQFWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTT 93
Cdd:cd15943   2 FILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  94 IQFDACLIQMFAIHSLSGMESTVLLAMAFDRYVAICHPLRHaTVLTLPRVAKIGMAAVVRGAALMAPLPVFIK-RLPFCR 172
Cdd:cd15943  82 ISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLY-TVIMSPRVCIQLVAGSYLIGFVNALIQTICTfRLPFCG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 173 SNILSHSYCLHQDVMKLACADIRVNIIYgLIVIISAIGL-DSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVF 250
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVNEIV-LFAFAIFLGIfTSLEILVSYVYILSAILRIhSSEGRRKAFSTCASHLMAVT 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 251 IFY--VPFIGLSMVHRFSKRHDSLLPVimanIYLLVPPVLNPIVYGVKTKEIRQRILRLF 308
Cdd:cd15943 240 IFYgtTLFMYLRPSSSYSLDQDKVVSV----FYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
35-302 6.59e-50

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 167.22  E-value: 6.59e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  35 SLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMES 114
Cdd:cd15424   9 IIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 115 TVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADI 194
Cdd:cd15424  89 LLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACADT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 195 RVN--IIYGLIVIISAIGLDSLFISFSylLILKTVLGLTREA-QAKAFGTCVSHVCAVFIFYVPFIGLSMVHRF--SKRH 269
Cdd:cd15424 169 HITeaIVFGAGVLILLVPLSVILTSYG--LILASVLQMQSAAgRHKAFSTCASHLAVVTLFYGTVISMYMRPRSgsTPDR 246
                       250       260       270
                ....*....|....*....|....*....|...
gi 47577687 270 DSLLPVimanIYLLVPPVLNPIVYGVKTKEIRQ 302
Cdd:cd15424 247 DKQIAV----FYIVITPLLNPIIYTLRNKDVHG 275
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
14-308 3.25e-49

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 165.91  E-value: 3.25e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  14 FILIGLPGLEEFQFWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTT 93
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  94 IQFDACLIQMFAIHSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRS 173
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 174 NILSHSYCLHQDVMKLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIF 252
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIrSAEGRQKAFSTCASHLTAITIF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47577687 253 YVpfIGLSMVHRFSKRHdSLLPVIMANI-YLLVPPVLNPIVYGVKTKEIRQRILRLF 308
Cdd:cd15410 241 HG--TILFMYCRPSSSY-SLDTDKVASVfYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
37-301 3.62e-49

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 165.08  E-value: 3.62e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  37 YLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMESTV 116
Cdd:cd15229  11 YLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 117 LLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGA--ALMAPLPVFikRLPFCRSNILSHSYCLHQDVMKLACADI 194
Cdd:cd15229  91 LSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFlyALINTLLLL--NLHFCGPNEINHFSCELPSLLPLSCSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 195 RVNIIYGLIVIIsAIGLDSLFISF-SYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMvhRFSKRHDSL 272
Cdd:cd15229 169 FANKMVLLTSSV-IFGLGSFLLTLvSYIHIISTILRIrSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYL--RPNSASSSV 245
                       250       260
                ....*....|....*....|....*....
gi 47577687 273 LPVIMANIYLLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15229 246 LDRVFSIQYSILTPMLNPIIYSLKNKEVK 274
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
36-301 4.16e-49

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 165.12  E-value: 4.16e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15417  10 IYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTECF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRG--AALMAPLPVFikRLPFCRSNILSHSYCLHQDVMKLACAD 193
Cdd:cd15417  90 LLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGflNSLIQTVSMF--QLSFCGPNVIDHFFCDIPPLLSLSCSD 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 194 IRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGLTR-EAQAKAFGTCVSHVCAVFIFYVPfiGLSMVHRFSKRHDSL 272
Cdd:cd15417 168 TFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSaKGRSKAFNTCASHLTAVTLFYGT--GLFVYLRPSSSHSQD 245
                       250       260
                ....*....|....*....|....*....
gi 47577687 273 LPVIMANIYLLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15417 246 QDKVASVFYTVVIPMLNPLIYSLRNKEIK 274
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
36-293 1.13e-48

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 163.63  E-value: 1.13e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15915  10 LYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEAM 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHaTVLTLPRVAkIGMAAVVRGAALMAPL--PVFIKRLPFCRSNILSHSYCLHQDVMKLACAD 193
Cdd:cd15915  90 LLAVMAYDRYVAICNPLRY-TVIMNPQVC-LLLAVACWVTGFFHALmhTVMTSRLPFCGPNKINHFFCDIKPLLKLACGD 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 194 IR-----VNIIYGLIVIISaigldSLFISFSYLLILKTVLGLTR--EAQAKAFGTCVSHVCAVFIFYVPFIGLSMvhRFS 266
Cdd:cd15915 168 TSlnlwlLNIVTGSIALGT-----FILTLLSYIYIISFLLLKVRskEGRHKAFSTCASHLTVVLLLYGPALFTYI--RPS 240
                       250       260
                ....*....|....*....|....*..
gi 47577687 267 KRHDSLLPVIMANIYLLVPPVLNPIVY 293
Cdd:cd15915 241 SGDSLEQDRIVALLYTVVTPVLNPLIY 267
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
36-301 1.31e-48

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 163.65  E-value: 1.31e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15420  10 LYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTECV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIR 195
Cdd:cd15420  90 LLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLACADTW 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 196 VNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRFSKRhdSLLP 274
Cdd:cd15420 170 INEILIFAGCVFILLGPFSLILISYLHILAAILKIqSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNS--AEQE 247
                       250       260
                ....*....|....*....|....*..
gi 47577687 275 VIMANIYLLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15420 248 KILSLFYSLFNPMLNPLIYSLRNKQVK 274
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
36-301 2.34e-48

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 162.96  E-value: 2.34e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15429  10 MYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEFI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTlPRVAkIGMAAVVRGAALMAPL--PVFIKRLPFCRSNILSHSYCLHQDVMKLACAD 193
Cdd:cd15429  90 LLAVMAYDRYVAVCHPLRYTVIMS-GGLC-IQLAAASWTSGFLNSLvqTAFTFRLPFCGHNTINHFSCELLAVVRLACVD 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 194 IRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMvhRFSKRHDSL 272
Cdd:cd15429 168 TSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIrSSEGRHKAFSTCASHLTVVSLCYGTAIFTYM--RPRSGSSAL 245
                       250       260
                ....*....|....*....|....*....
gi 47577687 273 LPVIMANIYLLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15429 246 QEKMISLFYAVVTPMLNPLIYSLRNKEVK 274
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
36-293 9.28e-48

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 161.23  E-value: 9.28e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15939  10 IYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIR 195
Cdd:cd15939  90 LLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACTDTY 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 196 VniiYGLIVIIS--AIGLDSLFI-SFSYLLILKTVLGLTREAQAKAFGTCVSHVCAVFIFYVPFIGLSMvhrfskRHDSL 272
Cdd:cd15939 170 V---IGLLVVANsgLICLLSFLIlLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYM------RPVTT 240
                       250       260
                ....*....|....*....|...
gi 47577687 273 LPV--IMANIYLLVPPVLNPIVY 293
Cdd:cd15939 241 FPIdkVVAVFYTIITPMLNPLIY 263
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
27-293 1.94e-47

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 160.50  E-value: 1.94e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  27 FWLAFplcSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAI 106
Cdd:cd15232   4 FWLFL---FLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 107 HSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDV 186
Cdd:cd15232  81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 187 MKLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFY--VPFIGLSMVH 263
Cdd:cd15232 161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIrSTEGKKKAFSTCSSHLIVVSLYYstVIYTYIRPSS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 47577687 264 RFSKRHDSllpvIMANIYLLVPPVLNPIVY 293
Cdd:cd15232 241 SYSPEKDK----VVAVLYSVVTPTLNPLIY 266
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
36-306 1.97e-47

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 160.61  E-value: 1.97e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15416  10 IYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVECF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTlPRVAKIGMAAVVRGAALMAPL-PVFIKRLPFCRSNILSHSYCLHQDVMKLACADI 194
Cdd:cd15416  90 LLAAMAYDRYVAICNPLLYSTIMS-QKVCVLLVAASYLGGCLNALVfTTCVFSLSFCGPNEINHFFCDFPPLLKLSCSDI 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 195 RVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFY--VPFIGLSMVHRFSKRHDS 271
Cdd:cd15416 169 RLAKILPSISSGIIILVTVLTIIISYLYILIAILRIrSTEGRHKAFSTCASHLTAVTLFYgtITFIYVMPNSSYSMDQNK 248
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577687 272 LLPVimanIYLLVPPVLNPIVYGVKTKEIRQRILR 306
Cdd:cd15416 249 VVSV----FYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
35-302 7.76e-47

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 158.89  E-value: 7.76e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  35 SLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMES 114
Cdd:cd15234   9 SMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDN 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 115 TVLLAMAFDRYVAICHPLRHaTVLTLPRVAKIgMAAVVRGAALMAPLP--VFIKRLPFCRSNILSHSYCLHQDVMKLACA 192
Cdd:cd15234  89 FLLAVMAYDRYVAICHPLHY-TVIMNPCLCGL-LVLLSLLISILDSLLhsLMVLQLSFCTDVEIPHFFCELAQVLKLACS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 193 DIRVNIIygLIVIISAI--GLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYvpFIGLSMVHRFSKRH 269
Cdd:cd15234 167 DTLINNI--LIYLATVIfgGIPLSGIIFSYYKIVSSILRIpSSGGKYKAFSTCGSHLSVVSLFY--GTGLGVYISSAVTH 242
                       250       260       270
                ....*....|....*....|....*....|...
gi 47577687 270 DSLLPVIMANIYLLVPPVLNPIVYGVKTKEIRQ 302
Cdd:cd15234 243 SSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKG 275
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
34-293 1.10e-46

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 158.52  E-value: 1.10e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  34 CSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGME 113
Cdd:cd15226   8 SLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSE 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 114 STVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACAD 193
Cdd:cd15226  88 MVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLACTD 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 194 irvniIYGL-IVIISAIGLDSLFISF----SYLLILKTVLGLTREAQAKAFGTCVSHVCAVFIFYVPFIGLSMvhrfskR 268
Cdd:cd15226 168 -----TYVLeLMVVANSGLISLVCFLllliSYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYV------W 236
                       250       260
                ....*....|....*....|....*..
gi 47577687 269 HDSLLPV--IMANIYLLVPPVLNPIVY 293
Cdd:cd15226 237 PFSTFPVdkFLAVFYTVITPLLNPIIY 263
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
36-293 1.31e-46

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 158.17  E-value: 1.31e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15947  10 FYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGSTECV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHaTVLTLPRVAkIGMAAVVRGAALMAPL--PVFIKRLPFCRSNILSHSYCLHQDVMKLACAD 193
Cdd:cd15947  90 LLAVMAFDRYVAVCRPLHY-TVIMHPRLC-VQLAALSWLSGLANSLlqTTLTLQLPLCGHHTLDHFFCEVPALIKLACVD 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 194 IRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMV--HRFSKRHD 270
Cdd:cd15947 168 TTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIkSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQppSSYSQDQG 247
                       250       260
                ....*....|....*....|...
gi 47577687 271 SLLpvimANIYLLVPPVLNPIVY 293
Cdd:cd15947 248 KFI----SLFYTVVTPTLNPLIY 266
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
36-302 2.63e-46

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 157.86  E-value: 2.63e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15419  10 IYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEGF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIR 195
Cdd:cd15419  90 LLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLSCSDTF 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 196 VNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFY--VPFIGLSMVHRFSKRHDSl 272
Cdd:cd15419 170 INELVMFVLCGLIIVSTILVILVSYAYILSTILRIpSAEGRKKAFSTCASHLTAVSLFYgtVFFMYAQPGAVSSPEQSK- 248
                       250       260       270
                ....*....|....*....|....*....|
gi 47577687 273 lpvIMANIYLLVPPVLNPIVYGVKTKEIRQ 302
Cdd:cd15419 249 ---VVSVFYTLVIPMLNPLIYSLRNKDVKE 275
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
14-306 2.14e-45

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 155.67  E-value: 2.14e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  14 FILIGLPGLEEFQFWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTT 93
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  94 IQFDACLIQMFAIHSLSGMESTVLLAMAFDRYVAICHPLrHATVLTLPRVAKIGMAAVVRGAALMAPLPV-FIKRLPFCR 172
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPL-LYTTAMSRRVCYLLLVGAYLSGMATSLVHTtLTFRLSFCG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 173 SNILSHSYCLHQDVMKLACADIRVN--IIYGLIVIISAIGLDSLFIsfSYLLILKTVLGL-TREAQAKAFGTCVSHVCAV 249
Cdd:cd15945 160 SNTINHFFCDIPPLLALSCSDTQINelLLFALCGFIQTSTFLAIII--SYCYIIITVLKIrSAEGRFKAFSTCASHLTAV 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47577687 250 FIFY--VPFIGLSMVHRFSKRHDSLLPVimanIYLLVPPVLNPIVYGVKTKEIRQRILR 306
Cdd:cd15945 238 GLFYgtLLFMYLRPSSSYSLDTDKMTSV----FYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
36-301 5.54e-45

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 154.50  E-value: 5.54e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15407  10 IYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFATVENF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIR 195
Cdd:cd15407  90 LLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALSCSDIH 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 196 VNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIglSMVHRFSKRHDSLLP 274
Cdd:cd15407 170 ISEIVLFFLASFNVFFALLVILISYLFIFITILRMrSAEGHQKAFSTCASHLTAVSIFYGTVI--FMYLQPSSSHSMDTD 247
                       250       260
                ....*....|....*....|....*..
gi 47577687 275 VIMANIYLLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15407 248 KMASVFYTMVIPMLNPLVYSLRNKEVK 274
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
37-293 6.01e-45

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 153.98  E-value: 6.01e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  37 YLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMESTV 116
Cdd:cd15224  11 YVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 117 LLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIRV 196
Cdd:cd15224  91 LAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCTDMSL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 197 NIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVpfIGLSMVHRFSKRHDSLLPV 275
Cdd:cd15224 171 AELVDFILALIILLVPLLVTVASYICIISTVLRIpSATGRQKAFSTCASHLTVVIIFYS--ATLFMYARPKAISSFDSNK 248
                       250
                ....*....|....*...
gi 47577687 276 IMANIYLLVPPVLNPIVY 293
Cdd:cd15224 249 LVSVLYTVVTPLLNPIIY 266
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
37-293 6.97e-45

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 153.79  E-value: 6.97e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  37 YLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMESTV 116
Cdd:cd15911  11 YIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATECYL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 117 LLAMAFDRYVAICHPLRHATVLTlPRVAkIGMAAV--VRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADI 194
Cdd:cd15911  91 LAVMSYDRYLAICKPLHYASLMN-GRLC-LQLAAGswISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 195 RvnIIYGLIVIISAIG--LDSLFISFSYLLILKTVLGL--TREAQaKAFGTCVSHVCAVFIFYVPFIGLSMVHrfSKRHD 270
Cdd:cd15911 169 S--LVELVTFILSSIVtlPPFLLTLTSYICIISTILRIpsTTGRQ-KAFSTCSSHLIVVTIFYGTLIIVYVVP--STNTS 243
                       250       260
                ....*....|....*....|...
gi 47577687 271 SLLPVIMANIYLLVPPVLNPIVY 293
Cdd:cd15911 244 RDLNKVFSLFYTVLTPLVNPLIY 266
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
36-306 1.02e-44

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 153.72  E-value: 1.02e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15409  10 IYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTlPRVAKIGMAAVVRGAALMAPLPV-FIKRLPFCRSNILSHSYCLHQDVMKLACADI 194
Cdd:cd15409  90 LLAAMAYDRYVAICNPLLYPVVMS-NRLCVQLITASYIGGFLHSMIHVgLTFRLSFCGSNEINHFFCDIPPLLKISCTDP 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 195 RVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRFSKRHDSLL 273
Cdd:cd15409 169 SINELVLFIFSGSIQVFTILTVLISYSYILFTILKMkSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYALDQDM 248
                       250       260       270
                ....*....|....*....|....*....|...
gi 47577687 274 PVimANIYLLVPPVLNPIVYGVKTKEIRQRILR 306
Cdd:cd15409 249 MD--SLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
36-301 3.53e-44

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 152.22  E-value: 3.53e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFW-FNSTTIQFDACLIQMFAIHSLSGMES 114
Cdd:cd15916  10 IYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLePGGKVISFGGCVAQLYFFHFLGSTEC 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 115 TVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADI 194
Cdd:cd15916  90 FLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACADT 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 195 RVNiiygLIVIISAIGLDSL----FISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVP--FIGLSMVHRFSk 267
Cdd:cd15916 170 TIN----ELVIFASIGVVALgcfiLILLSYGNIVRAILRIrTAEGRRRAFSTCASHLIVVLCFYVPcvFIYLRPGSKEA- 244
                       250       260       270
                ....*....|....*....|....*....|....
gi 47577687 268 rhdslLPVIMANIYLLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15916 245 -----LDGVIAVFYTVVTPLLNPLIYTLRNKEVK 273
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
37-293 5.10e-44

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 151.46  E-value: 5.10e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  37 YLIAVLGNLTIIYIVRTE-HRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15935  11 YAAILLGNLLIVVTVHADpHLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEML 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIR 195
Cdd:cd15935  91 LLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIKLACMDTY 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 196 VNiiygLIVIISAIGLDSL----FISFSYLLILKTVLGLTREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRFSKRHDS 271
Cdd:cd15935 171 VV----EVLMVANSGLLSLvcflVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSSSSVDK 246
                       250       260
                ....*....|....*....|..
gi 47577687 272 LLPVimanIYLLVPPVLNPIVY 293
Cdd:cd15935 247 VASV----FYTLITPALNPLIY 264
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
18-301 9.62e-44

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 151.37  E-value: 9.62e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  18 GLPGLEEFQFWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFD 97
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  98 ACLIQMFAIHSLSGMESTVLLAMAFDRYVAICHPLRHATVLTlPRVAKIGMAAVVRGAALMAPL-PVFIKRLPFCRSNIL 176
Cdd:cd15406  81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMS-PRVCSLLVAGVYIMGLIGATVhTSCMLRLSFCGDNVI 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 177 SHSYCLHQDVMKLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVP 255
Cdd:cd15406 160 NHYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIrSAEGRSKAFSTCSSHLAAVGVFYGS 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 47577687 256 FIGlsMVHRFSKRHDSLLPVIMANIYLLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15406 240 IIF--MYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVK 283
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
29-301 1.79e-43

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 150.27  E-value: 1.79e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  29 LAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHS 108
Cdd:cd15228   3 LFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 109 LSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMK 188
Cdd:cd15228  83 LGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 189 LACADIRVniiyGLIVIISAIGLDS----LFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVH 263
Cdd:cd15228 163 LACADTSI----AETVSFTNVGLVPltcfLLILASYVRIVISILKMrSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQP 238
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47577687 264 RFSKRHDSLLPVIMAniylLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15228 239 TPSPVLVTPVQIFNN----VVTPMLNPLIYTLRNKEVK 272
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
36-293 3.09e-43

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 149.39  E-value: 3.09e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15913  10 IYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTTECF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGaALMAPLPVF-IKRLPFCRSNILSHSYCLHQDVMKLAC--A 192
Cdd:cd15913  90 FLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCG-FLWFLIPVVlISQLPFCGPNIIDHFLCDPGPLLALSCvpA 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 193 DIRVNIIYGLIVIIsaIGLDSLFISFSYLLILKTVLGLTREA-QAKAFGTCVSHVCAVFIFYvpfiGLSMVHRFS--KRH 269
Cdd:cd15913 169 PGTELICYTLSSLI--IFGTFLFILGSYTLVLRAVLRVPSAAgRHKAFSTCGSHLAVVSLFY----GSVMVMYVSpgSGN 242
                       250       260
                ....*....|....*....|....
gi 47577687 270 DSLLPVIMANIYLLVPPVLNPIVY 293
Cdd:cd15913 243 STGMQKIVTLFYSVVTPLLNPLIY 266
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
36-293 5.23e-43

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 148.74  E-value: 5.23e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15940  10 LYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIR 195
Cdd:cd15940  90 LLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACTDTY 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 196 VNIiyglIVIISAIGLDSL----FISFSYLLILKTVLGLTREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRFSKRHDS 271
Cdd:cd15940 170 LID----ILIVSNSGLISLvcfvALLGSYIVILVSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFSEDK 245
                       250       260
                ....*....|....*....|..
gi 47577687 272 LLPVimanIYLLVPPVLNPIVY 293
Cdd:cd15940 246 VVSV----FYTVVTPLLNPIIY 263
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
36-293 7.27e-43

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 148.64  E-value: 7.27e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15936  10 VYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEVF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIR 195
Cdd:cd15936  90 LLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACTDTF 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 196 VniiyGLIVIISAIGLDSLFISF----SYLLILKTVLGLTREAQAKAFGTCVSHVCAV--------FIFYVPFIGLSMvh 263
Cdd:cd15936 170 L----LELLMVSNSGLVTLLIFFilliSYTVILVKIRTHVTEGKRKALSTCASQITVVtlifvpciYIYARPFQTFPM-- 243
                       250       260       270
                ....*....|....*....|....*....|
gi 47577687 264 rfskrhDSLLPVimanIYLLVPPVLNPIVY 293
Cdd:cd15936 244 ------DKAVSV----LYTVITPMLNPMIY 263
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
36-301 3.84e-42

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 146.76  E-value: 3.84e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15434  10 FYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGGTECV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLrHATVLTLPRVAKiGMAAV-----VRGAALMAPlpvFIKRLPFCRSNILSHSYCLHQDVMKLA 190
Cdd:cd15434  90 LLAVMAYDRYAAVCQPL-HYTVVMHPRLCW-KLVAMswligFGNSLVLSP---LTLSLPRCGHHRVDHFFCEMPALIKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 191 CADIRV--NIIYGLIVIISAIGLdsLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMV--HRF 265
Cdd:cd15434 165 CVDTTAyeATIFALGVFILLFPL--SLILVSYGYIARAVLKIkSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQpkNSV 242
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577687 266 SKRHDSLLpvimANIYLLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15434 243 SQDQGKFL----TLFYTIVTPSLNPLIYTLRNKDVK 274
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
36-306 4.16e-42

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 146.79  E-value: 4.16e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15415  10 IYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEGF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIR 195
Cdd:cd15415  90 LLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSDTH 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 196 VN--IIYGLIVIISAIGLdsLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPfIGLSMVHRfSKRHDSL 272
Cdd:cd15415 170 INelLLLTFSGVIAMSTL--LTIIISYIFILFAILRIrSAEGRRKAFSTCASHLTAVTLFYGS-VSFSYIQP-SSQYSLE 245
                       250       260       270
                ....*....|....*....|....*....|....
gi 47577687 273 LPVIMANIYLLVPPVLNPIVYGVKTKEIRQRILR 306
Cdd:cd15415 246 QEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
36-301 4.67e-42

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 146.70  E-value: 4.67e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15413  10 IYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLrHATVLTLPRVAKIGMAAVVRGAALMAPL-PVFIKRLPFCRSNILSHSYCLHQDVMKLACADI 194
Cdd:cd15413  90 LLSAMAYDRYVAICNPL-LYTVIMSQRVCIVLVAIPYLYSFFVALFhTIKTFRLSFCGSNVINHFYCDDLPLLALSCSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 195 RVniIYGLIVIISAIGL-DSLFISF-SYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIglSMVHRFSKRHdS 271
Cdd:cd15413 169 HE--KELIILIFAGFNLiSSLLIVLvSYLFILSAILRIrSAEGRQKAFSTCGSHLTVVTIFYGTLI--FMYLQPKSSH-S 243
                       250       260       270
                ....*....|....*....|....*....|.
gi 47577687 272 LLPVIMANI-YLLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15413 244 LDTDKMASVfYTLVIPMLNPLIYSLRNKEVK 274
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
25-302 3.44e-41

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 144.61  E-value: 3.44e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  25 FQFWLAFPLcsLYLIAVLGNLTIIYIVRTEHRLHE-PMYIFLCMLSGLDILISTSSMPKMMAIFWFNS-TTIQFDACLIQ 102
Cdd:cd15941   1 SLFFLLFLL--IYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQ 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 103 MFAIHSLSGMESTVLLAMAFDRYVAICHPLRHATVLTlpRVAKIGMAAV--VRGAALMAPLPVFIKRLPFCRSNILSHSY 180
Cdd:cd15941  79 LYAFHFLASTECFLYTVMAYDRYLAICHPLHYPTAMN--RRMCAGLAGGtwATGATHAAIHTSLTFRLPYCGPCQIAYFF 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 181 CLHQDVMKLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGL 259
Cdd:cd15941 157 CDIPPVLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIrTAEGRQRAFSTCSAHLTGVLLYYVPSVFI 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 47577687 260 SMVHRFSKRHDSLLPVimanIYLLVPPVLNPIVYGVKTKEIRQ 302
Cdd:cd15941 237 YLQPSSSQAGAGAPAV----FYTIVTPMLNPFIYTLRNKEVKR 275
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
35-309 8.87e-41

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 143.72  E-value: 8.87e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  35 SLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMES 114
Cdd:cd15414   9 LVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 115 TVLLAMAFDRYVAICHPLRHaTVLTLPRVAkIGMAAVVRGAALMAPL--PVFIKRLPFCRSNILSHSYCLHQDVMKLACA 192
Cdd:cd15414  89 FLLASMAYDRYVAICNPLLY-TVIMSQRVC-VQLVVGPYVVGLLNTTthTTAAFFLPFCGPNVINHFFCDIPPLLSLSCA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 193 DIRVNIIYgLIVIISAIG-LDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVP--FIGLSMVHRFSKR 268
Cdd:cd15414 167 DTQINKWV-LFIMAGALGvLSGLIILVSYIYILIAILRIrSAEGRRKAFSTCSSHLTAVSILYGTlfFIYVRPSSSSSLD 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47577687 269 HDSLLPVimanIYLLVPPVLNPIVYGVKTKEIRQRILRLFL 309
Cdd:cd15414 246 LDKVVSV----FYTAVIPMLNPLIYSLRNKEVKDALRRTIR 282
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
36-296 1.96e-40

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 142.23  E-value: 1.96e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15946  10 IYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECT 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIR 195
Cdd:cd15946  90 LFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKLACADTS 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 196 VN----IIYGLIVIISAIGLdslfISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVP--FIGLSMVHRFSKR 268
Cdd:cd15946 170 LNemvdFVLGVIVLVVPLSL----ILASYVNIFKAILKIrSTQGRCKAFSTCASHITVVTMFYGPamFMYMRPGSNYSPE 245
                       250       260
                ....*....|....*....|....*...
gi 47577687 269 HDSLlpviMANIYLLVPPVLNPIVYGVK 296
Cdd:cd15946 246 RDKK----ISLFYNVFTALLNPVIYSLR 269
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
37-302 5.24e-40

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 141.46  E-value: 5.24e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  37 YLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMESTV 116
Cdd:cd15432  11 YILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGSTECVL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 117 LLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIRV 196
Cdd:cd15432  91 LAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCVDTTA 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 197 NIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRFSKRHDSllPV 275
Cdd:cd15432 171 NEAELFVISVLLLLIPLGLILISYIFIVRAVLRIrSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNSSHDR--GK 248
                       250       260
                ....*....|....*....|....*..
gi 47577687 276 IMANIYLLVPPVLNPIVYGVKTKEIRQ 302
Cdd:cd15432 249 MVALFYGIITPMLNPLIYTLRNKDVKE 275
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
36-301 9.41e-40

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 140.65  E-value: 9.41e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15942  10 VYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAECF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIR 195
Cdd:cd15942  90 LYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADTA 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 196 VNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPfigLSMVHRFSKRHDSLLP 274
Cdd:cd15942 170 FNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIpSAEGQRRAFSTCTAHLTVVVIYYVP---LTFIYLRPGSQDPLDG 246
                       250       260
                ....*....|....*....|....*..
gi 47577687 275 VImANIYLLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15942 247 VV-AVFYTTVTPLLNPVIYTLRNKEMK 272
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
35-302 3.24e-39

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 139.13  E-value: 3.24e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  35 SLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMES 114
Cdd:cd15236   9 AMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 115 TVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADI 194
Cdd:cd15236  89 FLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSST 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 195 RVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRFSKRHDSll 273
Cdd:cd15236 169 SLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVpSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSSDK-- 246
                       250       260
                ....*....|....*....|....*....
gi 47577687 274 PVIMANIYLLVPPVLNPIVYGVKTKEIRQ 302
Cdd:cd15236 247 DIVASVMYTVVTPMLNPFIYSLRNRDIKG 275
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
36-307 2.40e-38

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 137.22  E-value: 2.40e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15418  11 SYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSECF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIR 195
Cdd:cd15418  91 LLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACDDTR 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 196 VNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFigLSMVHRFSKRHDSLLP 274
Cdd:cd15418 171 VYELILYFILGFNVIAPTALILASYTFILAAILRIhSASGRHKAFSTCSAHLTSVTLYYGSI--LFIYSRPSSSHTPDRD 248
                       250       260       270
                ....*....|....*....|....*....|...
gi 47577687 275 VIMANIYLLVPPVLNPIVYGVKTKEIRQRILRL 307
Cdd:cd15418 249 KVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
14-308 5.04e-38

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 136.45  E-value: 5.04e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  14 FILIGLPGLEEFQFWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTT 93
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  94 IQFDACLIQMFAIHSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRS 173
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 174 NILSHSYCLHQDVMKLACADIRVN--IIYGLIVIISAIGLdsLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVF 250
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINeiLLYVFCGFVEMSSL--SIILISYLFILVAILRMrSAEGRRKAFSTCASHFTGVT 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 251 IFY--VPFIGLSMVHRFSKRHDSLLPVimanIYLLVPPVLNPIVYGVKTKEIRQRILRLF 308
Cdd:cd15944 239 LFYgtVIFMYLRPTSVYSLDQDKWASV----FYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
29-301 6.17e-37

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 133.31  E-value: 6.17e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  29 LAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHS 108
Cdd:cd15405   3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 109 LSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMK 188
Cdd:cd15405  83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQ 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 189 LACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFY--------VPFIGL 259
Cdd:cd15405 163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHIsSTEGRSKAFSTCSSHIIAVSLFFgsgafmylKPSSVG 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 47577687 260 SMVHRfskrhdsllpVIMANIYLLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15405 243 SVNQG----------KVSSVFYTNVVPMLNPLIYSLRNKDVK 274
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
36-301 6.35e-37

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 133.37  E-value: 6.35e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15428  10 IYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITECA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIR 195
Cdd:cd15428  90 LLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLASTDTH 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 196 VNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHR--FSKRHDSL 272
Cdd:cd15428 170 QAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMqSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKssTSKEYDKM 249
                       250       260
                ....*....|....*....|....*....
gi 47577687 273 LPVimanIYLLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15428 250 ISV----FYIIVTPMLNPLIYSLRNKEVK 274
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
37-301 2.27e-36

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 131.84  E-value: 2.27e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  37 YLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMESTV 116
Cdd:cd15233  11 YIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 117 LLAMAFDRYVAICHPLRHATVLTlpRVAKIGMAAVVRGAALMAPL--PVFIKRLPFCRSNILSHSYCLHQDVMKLACADI 194
Cdd:cd15233  91 LTAMAYDRYLAICQPLTYSVRMS--WRVQTALVGISCACAFTNALthTVAMSTLKFCGPNVINHFFCDLPPLFQLSCSST 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 195 RVNIIYgLIVIISAIGLDSL-FISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFYVPFIGLSMvhRFSKRHDSL 272
Cdd:cd15233 169 HLNELL-LFVFAFFMALAPCvLIVVSYAHVVAAVLRIrSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYM--RLGSVYSSD 245
                       250       260
                ....*....|....*....|....*....
gi 47577687 273 LPVIMANIYLLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15233 246 KDKVIGILNTVLSPMLNPLIYSLRNKDVK 274
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
27-293 3.97e-35

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 128.32  E-value: 3.97e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  27 FWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAI 106
Cdd:cd15937   1 LLLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 107 HSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDV 186
Cdd:cd15937  81 HFLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 187 MKLACADI-RVNIIY----GLIVIISAIGldsLFISFSYLLILktVLGLTREAQAKAFGTCVSHVCAVFIFYVPFIGLsM 261
Cdd:cd15937 161 IKLACTNTyTVELLMfsnsGLVILLCFLL---LLISYAFLLAK--LRTHSSKGKSKAASTCITHIIIVFVMFGPAIYI-Y 234
                       250       260       270
                ....*....|....*....|....*....|..
gi 47577687 262 VHRFskrHDSLLPVIMANIYLLVPPVLNPIVY 293
Cdd:cd15937 235 ARPF---RSFPMDKVVAVFHTVIFPLLNPMIY 263
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
37-301 4.12e-34

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 125.67  E-value: 4.12e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  37 YLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMESTV 116
Cdd:cd15433  11 YLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAECVL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 117 LLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIRV 196
Cdd:cd15433  91 LAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLACGDDET 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 197 NIIYGLIVIISAIGLDSLFISFSYLLILKTVLGL-TREAQAKAFGTCVSHVCAVFIFY--VPFIGLSMVHRFSKRHDSLL 273
Cdd:cd15433 171 TEVQMFVARVVILLLPAALILGSYGHVAHAVLRIkSSAGRRRAFGTCGSHLMVVFLFYgsAIYTYLQPIHRYSQAHGKFV 250
                       250       260
                ....*....|....*....|....*...
gi 47577687 274 pvimANIYLLVPPVLNPIVYGVKTKEIR 301
Cdd:cd15433 251 ----SLFYTVMTPALNPLIYTLRNKDVK 274
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
37-296 1.99e-33

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 123.83  E-value: 1.99e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  37 YLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMESTV 116
Cdd:cd15938  11 YTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 117 LLAMAFDRYVAICHPLRHATVLTlPRVAKIGMAAVVRGAALMAPL-PVFIKRLPFCRSNILSHSYCLHQDVMKLACADIR 195
Cdd:cd15938  91 LTVMAYDRYVAICKPLHYTTIMS-RRLCWVLVAASWAGGFLHSIVqTLLTIQLPFCGPNQVNNFFCDVPPVIKLACTDTC 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 196 VNIIY-----GLIVIISAIGLDSlfisfSYLLILKTVlgLTREAQAKAFGTCVSHVCAVFIFYVPFIGLSMvhrfskRHD 270
Cdd:cd15938 170 VTELLmvsnsGLISTVCFVVLVT-----SYTTILVTI--RSTEGRRKALSTCASHLMVVTLFFGPCIFIYA------RPF 236
                       250       260
                ....*....|....*....|....*...
gi 47577687 271 SLLPV--IMANIYLLVPPVLNPIVYGVK 296
Cdd:cd15938 237 STFPVdkHVSVLYNVITPMLNPLIYTLR 264
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
43-293 3.86e-23

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 95.83  E-value: 3.86e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687    43 GNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMA-IFWFNSTTIQFDACLIQMFAIHSLSGMESTVLLAMA 121
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVyYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687   122 FDRYVAICHPLRHATVLTlPRVAKIGMAAV-VRGAALMAPLPVFIKRLPFCRSNilsHSYCLHQDVMKLACadirvNIIY 200
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRT-PRRAKVLILVIwVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSK-----PVSY 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687   201 GLIVIISAIGLDSLFISFSYLLILKTVL--------GLTREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRF------S 266
Cdd:pfam00001 152 TLLISVLGFLLPLLVILVCYTLIIRTLRksaskqksSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLaldcelS 231
                         250       260
                  ....*....|....*....|....*..
gi 47577687   267 KRHDSLLPVIMANIYllVPPVLNPIVY 293
Cdd:pfam00001 232 RLLDKALSVTLWLAY--VNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
29-296 6.89e-20

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 87.34  E-value: 6.89e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  29 LAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHS 108
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 109 LSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYClhqdvmk 188
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWP------- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 189 lacaDIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTV---------------LGLTREAQAKAFGTCVSHVCAVFIFY 253
Cdd:cd00637 154 ----DLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLrrhrrrirssssnssRRRRRRRERKVTKTLLIVVVVFLLCW 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 47577687 254 VPFIGLSMVHRFSKRHDSLLPVIMANIYLLV--PPVLNPIVYGVK 296
Cdd:cd00637 230 LPYFILLLLDVFGPDPSPLPRILYFLALLLAylNSAINPIIYAFF 274
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
28-302 2.70e-13

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 68.36  E-value: 2.70e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  28 WLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMP-----KMMAIFWFNSTTIQFDACLIQ 102
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPfsavyTLLGYWPFGPVLCRFWIALDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 103 MFAIHSLSGmestvLLAMAFDRYVAICHPLRHATVLTlPRVAKIGMAAVVRGAALMAPLPVFIKRLPfcRSNILSHSYCL 182
Cdd:cd14967  81 LCCTASILN-----LCAISLDRYLAITRPLRYRQLMT-KKRALIMIAAVWVYSLLISLPPLVGWRDE--TQPSVVDCECE 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 183 HQdvmklacadirVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLgltREaqAKAFGTcVSHVCAVFIF-YVPFIGLSM 261
Cdd:cd14967 153 FT-----------PNKIYVLVSSVISFFIPLLIMIVLYARIFRVAR---RE--LKAAKT-LAIIVGAFLLcWLPFFIIYL 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 47577687 262 VHRFSkRHDSLLPVIMANIYLL--VPPVLNPIVYGVKTKEIRQ 302
Cdd:cd14967 216 VSAFC-PPDCVPPILYAVFFWLgyLNSALNPIIYALFNRDFRR 257
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
34-164 7.20e-10

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 58.84  E-value: 7.20e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  34 CSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIhsLSGME 113
Cdd:cd14972   6 IVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLV--LSLLA 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577687 114 STV-LLAMAFDRYVAICHPLRHATVLTLPRVaKIGMAAVVRGAALMAPLPVF 164
Cdd:cd14972  84 SAYsLLAIAVDRYISIVHGLTYVNNVTNKRV-KVLIALVWVWSVLLALLPVL 134
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
33-261 4.04e-09

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 56.47  E-value: 4.04e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  33 LCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIfwfnSTTIQFDA----C----LIQMF 104
Cdd:cd15196   7 LATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVLPQLIW----DITYRFYGgdllCrlvkYLQVV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 105 AIHsLSgmeSTVLLAMAFDRYVAICHPLRHATVltLPRVAKIgMAAVVRGAALMAPLP-VFIKRLPFCRSNILSHSYCLH 183
Cdd:cd15196  83 GMY-AS---SYVLVATAIDRYIAICHPLSSHRW--TSRRVHL-MVAIAWVLSLLLSIPqLFIFSYQEVGSGVYDCWATFE 155
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47577687 184 QDVmklacadirVNIIYGLIVIISAIGLDSLFISFSYLLILKTVlgltREAQAKAFGTCVSHVCAVFIFYVPFIGLSM 261
Cdd:cd15196 156 PPW---------GLRAYITWFTVAVFVVPLIILAFCYGRICYVV----WRAKIKTVKLTLVVVACYIVCWTPFFVVQM 220
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
35-146 6.49e-09

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 55.96  E-value: 6.49e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  35 SLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQ--------MFAI 106
Cdd:cd15103   9 TLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQhidnvidsMICS 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 47577687 107 HSLSGMEStvLLAMAFDRYVAICHPLRHATVLTLPRVAKI 146
Cdd:cd15103  89 SLLASICS--LLAIAVDRYITIFYALRYHSIMTVRRAGVI 126
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
33-304 2.70e-08

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 54.33  E-value: 2.70e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  33 LCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPkmMAIFWFnsTTIQFDA----CLIQMFAihS 108
Cdd:cd15195   7 TWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMP--MDAVWN--YTVEWLAgdlmCRVMMFL--K 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 109 LSGM--ESTVLLAMAFDRYVAICHPLRHATVLTLPRVAkIGMAAVVRGAALMAPLPVFIKRLPFCRSNILshsyclHQdv 186
Cdd:cd15195  81 QFGMylSSFMLVVIALDRVFAILSPLSANQARKRVKIM-LTVAWVLSALCSIPQSFIFSVLRKMPEQPGF------HQ-- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 187 mklaCADIRVNI------IYGLIVIISAIGLDSLFISFSYLLILKTVLGLTRE-------------------AQAKAFGT 241
Cdd:cd15195 152 ----CVDFGSAPtkkqerLYYFFTMILSFVIPLIITVTCYLLILFEISKMAKRardtpisnrrrsrtnslerARMRTLRM 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47577687 242 CVSHVCAVFIFYVPFIGLSMVHRFSKRHDSLLPVIMANIYLLV---PPVLNPIVYGVKTKEIRQRI 304
Cdd:cd15195 228 TALIVLTFIVCWGPYYVLGLWYWFDKESIKNLPPALSHIMFLLgylNPCLHPIIYGVFMKEIRNWI 293
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
34-164 3.48e-08

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 53.83  E-value: 3.48e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  34 CSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDA-CLIQMFAIHSLSGM 112
Cdd:cd14997   8 GVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREPWLLGEFmCKLVPFVELTVAHA 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577687 113 ESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIgmAAVVRGAALMAPLPVF 164
Cdd:cd14997  88 SVLTILAISFERYYAICHPLQAKYVCTKRRALVI--IALIWLLALLTSSPVL 137
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
35-146 1.68e-07

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 51.72  E-value: 1.68e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  35 SLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMF----AIHSLS 110
Cdd:cd15351   9 FLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMdnviDTMICS 88
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 47577687 111 GMESTV--LLAMAFDRYVAICHPLRHATVLTLPRVAKI 146
Cdd:cd15351  89 SVVSSLsfLGAIAVDRYITIFYALRYHSIMTLQRAVNA 126
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
35-146 1.79e-07

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 51.48  E-value: 1.79e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  35 SLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTI--------QFDACLIQMFAI 106
Cdd:cd15354   9 TLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLviedafvrHIDNVFDSLICI 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 47577687 107 HSLSGMEStvLLAMAFDRYVAICHPLRHATVLTLPRVAKI 146
Cdd:cd15354  89 SVVASMCS--LLAIAVDRYVTIFYALRYHNIMTVRRAGII 126
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
36-302 6.66e-07

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 50.05  E-value: 6.66e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMP-KMMAIFWFNSTTIQFDACLIQMFAIHSLSGMES 114
Cdd:cd14979  10 IFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPvELYNFWWQYPWAFGDGGCKLYYFLFEACTYATV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 115 TVLLAMAFDRYVAICHPLRHATVLTLPRVAKIgmAAVVRGAALMAPLPVFIKrlpfcrSNILSHSYCLHQDVMKLACADI 194
Cdd:cd14979  90 LTIVALSVERYVAICHPLKAKTLVTKRRVKRF--ILAIWLVSILCAIPILFL------MGIQYLNGPLPGPVPDSAVCTL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 195 RVNIIYGLIVIISAI----GLDSLFISFSYLLI---LKTVLGLTREAQAKAFGTCVSH----------------VCAVFI 251
Cdd:cd14979 162 VVDRSTFKYVFQVSTfiffVLPMFVISILYFRIgvkLRSMRNIKKGTRAQGTRNVELSlsqqarrqvvkmlgavVIAFFV 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47577687 252 FYVPF-IGLSMVHRFSKRHDSLLPV-----IMANIYLLVPPVLNPIVYGVKTKEIRQ 302
Cdd:cd14979 242 CWLPFhAQRLMFSYASKEDTFLFDFyqylyPISGILFYLSSAINPILYNLMSSRFRV 298
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
28-203 7.83e-07

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 49.70  E-value: 7.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  28 WLAFPLCSL-YLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMP-----KMMAIFWFNSTTIQfdacLI 101
Cdd:cd15206   1 ELIIPLYSViFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPftlvgQLLRNFIFGEVMCK----LI 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 102 QMFAIHSLSgMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPF-------CR-- 172
Cdd:cd15206  77 PYFQAVSVS-VSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMsrpgghkCRev 155
                       170       180       190
                ....*....|....*....|....*....|...
gi 47577687 173 --SNILSHSYCLHQDVMKLACADIRVNIIYGLI 203
Cdd:cd15206 156 wpNEIAEQAWYVFLDLMLLVIPGLVMSVAYGLI 188
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
35-146 1.66e-06

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 48.75  E-value: 1.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  35 SLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNST-------TIQFDACLIQMFAIH 107
Cdd:cd15353   9 TLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNGNdtdaqsfTVNIDNVIDSVICSS 88
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 47577687 108 SLSGMEStvLLAMAFDRYVAICHPLRHATVLTLPRVAKI 146
Cdd:cd15353  89 LLASICS--LLSIAVDRYFTIFYALQYHNIMTVRRAGVI 125
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
36-165 1.94e-06

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 48.44  E-value: 1.94e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMM-----AIFWFNSTTIQFdaclIQMFAIHSLS 110
Cdd:cd15390  10 MVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFtyllyNDWPFGLFYCKF----SNFVAITTVA 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47577687 111 GMESTvLLAMAFDRYVAICHPLRHatvlTLPRVAKIGMAAVVRGAALMAPLPVFI 165
Cdd:cd15390  86 ASVFT-LMAISIDRYIAIVHPLRP----RLSRRTTKIAIAVIWLASFLLALPQLL 135
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
33-227 2.04e-06

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 48.53  E-value: 2.04e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  33 LCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMpkMMAIFWfnSTTIQFDA----CLI----QMF 104
Cdd:cd14986   7 LGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTV--LTQIIW--EATGEWVAgdvlCRIvkylQVV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 105 AIHSLSGMestvLLAMAFDRYVAICHPLRHATVLTLPRVaKIGMAAVVrgaALMAPLP---VFIKR-----LPFCRSNIL 176
Cdd:cd14986  83 GLFASTYI----LVSMSLDRYQAIVKPMSSLKPRKRARL-MIVVAWVL---SFLFSIPqlvIFVERelgdgVHQCWSSFY 154
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 47577687 177 SHSYclhqdvmklacadIRVNIIYGLIVIISAiglDSLFISFSYLLILKTV 227
Cdd:cd14986 155 TPWQ-------------RKVYITWLATYVFVI---PLIILSYCYGRILRTI 189
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
36-225 2.52e-06

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 48.01  E-value: 2.52e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVrTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMA-IFWFNSTTIQFDACLIQMFAIHSLSGMES 114
Cdd:cd14978  10 ICIFGIIGNILNLVVL-TRKSMRSSTNVYLAALAVSDILVLLSALPLFLLpYIADYSSSFLSYFYAYFLPYIYPLANTFQ 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 115 TV----LLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLA 190
Cdd:cd14978  89 TAsvwlTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTLLRQNE 168
                       170       180       190
                ....*....|....*....|....*....|....*
gi 47577687 191 CADIRVNIIygLIVIISAIGLDSLFISFSYLLILK 225
Cdd:cd14978 169 TYLLKYYFW--LYAIFVVLLPFILLLILNILLIRA 201
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
34-304 3.55e-06

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 47.67  E-value: 3.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  34 CSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILIsTSSMPKMMAIFWFNSTTIQFDACLIQMfAIHSLSGME 113
Cdd:cd14970   8 SVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELF-LLGLPFLATSYLLGYWPFGEVMCKIVL-SVDAYNMFT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 114 STV-LLAMAFDRYVAICHPLRHATVLTlPRVAKIGMAAVVRGAALMApLPVFIkrlpfcRSNILSHSYCLHQDVMKL-AC 191
Cdd:cd14970  86 SIFcLTVMSVDRYLAVVHPVKSLRFRT-PRKAKLVSLCVWALSLVLG-LPVII------FARTLQEEGGTISCNLQWpDP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 192 ADI--RVNIIYGLIViisAIGLDSLFISFSYLLILK----TVLGLTREAQAKAFGT-----CVSHVCAVFIF-YVPFIGL 259
Cdd:cd14970 158 PDYwgRVFTIYTFVL---GFAVPLLVITVCYSLIIRrlrsSRNLSTSGAREKRRARrkvtrLVLVVVAVFVVcWLPFHVF 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 47577687 260 SMVHRFSKRHDSLLPVIMANIYLL---VPPVLNPIVYGVKTKEIRQRI 304
Cdd:cd14970 235 QIVRLLIDPPETLTVVGVFLFCIAlsyANSCLNPILYAFLDENFRKSF 282
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
35-142 5.60e-06

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 47.19  E-value: 5.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  35 SLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQ--------MFAI 106
Cdd:cd15352   9 TLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQhmdnvfdsMICI 88
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 47577687 107 HSLSGMEStvLLAMAFDRYVAICHPLRHATVLTLPR 142
Cdd:cd15352  89 SLVASICN--LLAIAVDRYVTIFYALRYHSIMTVRK 122
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
38-304 6.23e-06

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 46.87  E-value: 6.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  38 LIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILIsTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMESTVL 117
Cdd:cd14982  12 ILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLF-VLTLPFRIYYYLNGGWWPFGDFLCRLTGLLFYINMYGSILF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 118 LA-MAFDRYVAICHPLRhATVLTLPRVAKiGMAAVVRGAALMAPLPVFIKRLPFCRSNilSHSYCLHQDVMKLACADIRV 196
Cdd:cd14982  91 LTcISVDRYLAVVHPLK-SRRLRRKRYAV-GVCAGVWILVLVASVPLLLLRSTIAKEN--NSTTCFEFLSEWLASAAPIV 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 197 NIIYGLI-VIISAIgldslfISFSYLLILKTVLGLTREAQ-----AKAFGTCVSHVCAVFIFYVPF-----IGLSMVHRF 265
Cdd:cd14982 167 LIALVVGfLIPLLI------ILVCYSLIIRALRRRSKQSQksvrkRKALRMILIVLAVFLVCFLPYhvtriLYLLVRLSF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 47577687 266 SKRHDSLLPVIMANIYLL----VPPVLNPIVYGVKTKEIRQRI 304
Cdd:cd14982 241 IADCSARNSLYKAYRITLclasLNSCLDPLIYYFLSKTFRKRL 283
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
33-304 7.38e-06

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 46.82  E-value: 7.38e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  33 LCSLY----LIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMP-----KMMAIFWFNSTTIQFDACLIQM 103
Cdd:cd14993   3 LIVLYvvvfLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPltlleNVYRPWVFGEVLCKAVPYLQGV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 104 FAIHS-LSgmestvLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCL 182
Cdd:cd14993  83 SVSASvLT------LVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEPGTITIYI 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 183 hqdvmklaCADI----RVNIIYGLIVIISAIGLDSLFISFSYLLILKTvlgLTREAQAKAFGTCVSH------------- 245
Cdd:cd14993 157 --------CTEDwpspELRKAYNVALFVVLYVLPLLIISVAYSLIGRR---LWRRKPPGDRGSANSTssrrilrskkkva 225
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47577687 246 ---VCAVFIF---YVPFIGLSMVHRFSKRHDSLLPVIMANIYLLV------PPVLNPIVYGVKTKEIRQRI 304
Cdd:cd14993 226 rmlIVVVVLFalsWLPYYVLSILLDFGPLSSEESDENFLLILPFAqllgysNSAINPIIYCFMSKKFRRGF 296
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
34-181 7.53e-06

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 46.79  E-value: 7.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  34 CSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMP-----KMMAIFWFNSTTiqfdaCLIQMFAIHS 108
Cdd:cd15978   8 SLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPftlipNLLKDFIFGSAV-----CKTATYFMGI 82
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47577687 109 LSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYC 181
Cdd:cd15978  83 SVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFTRINNSTGNMC 155
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
28-302 9.40e-06

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 46.15  E-value: 9.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  28 WLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMP-KMMAIFWFNSTTIQFDACLIQMFAI 106
Cdd:cd15052   2 WAALLLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 107 HSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVA-KIGMAAVVrGAALMAPLPVFIKRLPfcrSNILSHSYCLHQD 185
Cdd:cd15052  82 VLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFlKIAIVWLI-SIGISSPIPVLGIIDT---TNVLNNGTCVLFN 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 186 vmklacadiRVNIIYGLIViisaigldSLFISFSYLLIL--KTVLGLTREAQA-KAFGTcvshVCAVF-IFYVPFIGLSM 261
Cdd:cd15052 158 ---------PNFVIYGSIV--------AFFIPLLIMVVTyaLTIRLLSNEQKAsKVLGI----VFAVFvICWCPFFITNI 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 47577687 262 VHRFSKRHDSLLPVIMANIYL---LVPPVLNPIVYGVKTKEIRQ 302
Cdd:cd15052 217 LTGLCEECNCRISPWLLSVFVwlgYVSSTINPIIYTIFNKTFRR 260
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
27-151 1.03e-05

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 46.43  E-value: 1.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  27 FWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFaI 106
Cdd:cd14969   1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGF-A 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47577687 107 HSLSGMESTVLLA-MAFDRYVAICHPLRhATVLTlPRVAKIGMAAV 151
Cdd:cd14969  80 VTFLGLVSISTLAaLAFERYLVIVRPLK-AFRLS-KRRALILIAFI 123
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
34-302 1.12e-05

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 46.31  E-value: 1.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  34 CSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPkmMAIFWFNSTTIQFDACLIQMFAIHSLSGME 113
Cdd:cd15070   8 ILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLFMSCLLVVFTHAS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 114 STVLLAMAFDRYVAICHPLRHATVLTLPRV-AKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSyCLHQDVMKLaca 192
Cdd:cd15070  86 IMSLLAIAVDRYLRVKLTVRYRIVTTQRRIwLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTTPLQ-CQFTSVMRM--- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 193 DIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGLT--REAQA---KAFGTCVSHVCAVFIFYVPFIGLSMVHRFSK 267
Cdd:cd15070 162 DYMVYFSFFTWILIPLVIMCALYVDIFYIIRNKLSQNATgfRETGAfygREFKTAKSLALVLFLFAVCWLPLSIINCVVY 241
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577687 268 RHDSLLPVIMANIYLL--VPPVLNPIVYGVKTKEIRQ 302
Cdd:cd15070 242 FNPKVPKIALYLGILLshANSMMNPIVYACKIKKFKE 278
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
33-304 1.32e-05

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 46.15  E-value: 1.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  33 LCSLYLIAVLGNLTIIYI-VRTEHRLHEPMYIFLCMLSGLDILISTSSMPkmMAIFWfnSTTIQFDA----CLIQMFAIH 107
Cdd:cd15382   7 YSVLFLIAAVGNLTVLLIlLRNRRRKRSRVNILLMHLAIADLLVTFIMMP--LEIGW--AATVAWLAgdflCRLMLFFRA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 108 SLSGMESTVLLAMAFDRYVAICHPLRhatVLTLPRVAKIGMAAVVRGAALMAPLPVFIkrlpFCRSNILSHSYcLHQDVM 187
Cdd:cd15382  83 FGLYLSSFVLVCISLDRYFAILKPLR---LSDARRRGRIMLAVAWVISFLCSIPQSFI----FHVESHPCVTW-FSQCVT 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 188 KLACADIRVNIIYGLIVIISAIGLDSLFISFSYLLILKTVLGLTREAQAKAFGTCVSH---------------------- 245
Cdd:cd15382 155 FNFFPSHDHELAYNIFNMITMYALPLIIIVFCYSLILCEISRKSKEKKEDVSEKSSSVrlrrssvgllerarsrtlkmti 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47577687 246 -VCAVFIF-YVPFIGLSMVHRFSKRHDSLLPVIMAN---IYLLVPPVLNPIVYGVKTKEIRQRI 304
Cdd:cd15382 235 vIVLVFIIcWTPYFIMSLWYWFDRESASKVDPRIQKglfLFAVSNSCMNPIVYGYFSIDLRREL 298
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
36-183 2.06e-05

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 45.19  E-value: 2.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMP-----KMMAIFWFNSTTIQFDACLIqmfaihSLS 110
Cdd:cd15979  10 IFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPftlipNLMGTFIFGEVICKAVAYLM------GVS 83
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47577687 111 GMESTV-LLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLH 183
Cdd:cd15979  84 VSVSTFsLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDRPRGHQCRH 157
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
27-184 3.11e-05

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 44.64  E-value: 3.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  27 FWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAI 106
Cdd:cd15389   1 ALLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 107 HSLSGMESTVLLAMAFDRYVAICHPLRhatvltlPRVAKIGMAAVVRGAALMA-----PLPVFIKRLPFCRSNILSHSYC 181
Cdd:cd15389  81 YCSVYVSTLTLTAIALDRHRVILHPLK-------PRITPCQGVVVIAIIWIMAsclslPHAIYQKLVEFEYSNERTRSRC 153

                ...
gi 47577687 182 LHQ 184
Cdd:cd15389 154 LPS 156
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
28-224 3.21e-05

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 44.80  E-value: 3.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  28 WLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIH 107
Cdd:cd15054   2 WVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 108 SLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRgAALMAPLPVFIK--RLPFCRSNILSHSYCLHQD 185
Cdd:cd15054  82 MCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTL-AALASFLPIELGwhELGHERTLPNLTSGTVEGQ 160
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 47577687 186 VMklacadIRVNIIYGLIVIISAIGLDSLFISFSYLLIL 224
Cdd:cd15054 161 CR------LLVSLPYALVASCLTFFLPSGAICFTYCRIL 193
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
38-144 4.03e-05

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 44.65  E-value: 4.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  38 LIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMM-----AIFWFNSTTIQFDACLIQMFAIHSLSGm 112
Cdd:cd15312  12 LLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMvrsveSCWYFGDLFCKIHSSLDMMLSTTSIFH- 90
                        90       100       110
                ....*....|....*....|....*....|..
gi 47577687 113 estvLLAMAFDRYVAICHPLRHATVLTLPRVA 144
Cdd:cd15312  91 ----LCFIAVDRYYAVCDPLHYRTKITTPVIK 118
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
38-152 4.97e-05

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 44.25  E-value: 4.97e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  38 LIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMESTVL 117
Cdd:cd15083  12 LIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTL 91
                        90       100       110
                ....*....|....*....|....*....|....*
gi 47577687 118 LAMAFDRYVAICHPLRHATVLTLPRVAkiGMAAVV 152
Cdd:cd15083  92 AAIAVDRYLVITRPMKASVRISHRRAL--IVIAVV 124
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
36-165 6.48e-05

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 43.72  E-value: 6.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSsMPKMMAIFWfNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15131  10 LFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLC-MPLDLYRLW-QYRPWNFGDLLCKLFQFVSESCTYST 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577687 116 VL--LAMAFDRYVAICHPLRHATVLTLPRVAKIGMaaVVRGAALMAPLPVFI 165
Cdd:cd15131  88 ILniTALSVERYFAICFPLRAKVVVTKRRVKLVIL--VLWAVSFLSAGPIFV 137
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
33-144 9.05e-05

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 43.31  E-value: 9.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  33 LCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMP----KMMAIFWFNSTTIqfdaCLIQmfaiHS 108
Cdd:cd15055   7 LSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPfsmiRSIETCWYFGDTF----CKLH----SS 78
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 47577687 109 LSGMESTV----LLAMAFDRYVAICHPLRHATVLTLPRVA 144
Cdd:cd15055  79 LDYILTSAsifnLVLIAIDRYVAVCDPLLYPTKITIRRVK 118
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
28-164 9.31e-05

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 43.38  E-value: 9.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  28 WLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMP-KMMAIFWFNSTTIQFDACLIQMFAI 106
Cdd:cd15304   2 WPALLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLD 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 47577687 107 HSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVF 164
Cdd:cd15304  82 VLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVF 139
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
38-164 9.33e-05

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 43.40  E-value: 9.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  38 LIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPkmMAIFWFNSTTIQFDACLIqmfaIHSLSGMESTV- 116
Cdd:cd14968  12 VLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCLF----MACLVLVLTQSs 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 47577687 117 ---LLAMAFDRYVAICHPLRHATVLTlPRVAKIGMAAVVRGAALMAPLPVF 164
Cdd:cd14968  86 ifsLLAIAIDRYLAIKIPLRYKSLVT-GRRAWGAIAVCWVLSFLVGLTPMF 135
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
36-164 1.10e-04

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 43.00  E-value: 1.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIV---RTEHRLHePMYIFLCMLSGLDILISTSSMPKMMAI----FWFN--STTIQFDACLIQMFai 106
Cdd:cd14981  10 MFVFGVLGNLLALIVLarsSKSHKWS-VFYRLVAGLAITDLLGILLTSPVVLAVyasnFEWDggQPLCDYFGFMMSFF-- 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 47577687 107 hSLSGMesTVLLAMAFDRYVAICHPLRHATVLTLPRvAKIGMAAVVRGAALMAPLPVF 164
Cdd:cd14981  87 -GLSSL--LIVCAMAVERFLAITHPFFYNSHVKKRR-ARLMLGAVWAFALLIASLPLL 140
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
33-134 1.12e-04

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 42.80  E-value: 1.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  33 LCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGM 112
Cdd:cd15050   7 LSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTA 86
                        90       100
                ....*....|....*....|..
gi 47577687 113 ESTVLLAMAFDRYVAICHPLRH 134
Cdd:cd15050  87 SIFSLFILCIDRYRSVQQPLKY 108
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
39-142 1.26e-04

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 43.00  E-value: 1.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  39 IAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPkmMAIFWFNSTTIQFDACLiqMFAIHSLSGMESTV-- 116
Cdd:cd15069  13 LSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIP--FAITISLGFCTDFHSCL--FLACFVLVLTQSSIfs 88
                        90       100
                ....*....|....*....|....*.
gi 47577687 117 LLAMAFDRYVAICHPLRHATVLTLPR 142
Cdd:cd15069  89 LLAVAVDRYLAIKVPLRYKSLVTGKR 114
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
38-141 1.33e-04

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 42.92  E-value: 1.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  38 LIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMP-----KMMAIFWFNSTTIQFDACLIQMFAIHSLSGm 112
Cdd:cd15318  12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPfstirSVESCWYFGDSFCRLHTCLDTLFCLTSIFH- 90
                        90       100
                ....*....|....*....|....*....
gi 47577687 113 estvLLAMAFDRYVAICHPLRHATVLTLP 141
Cdd:cd15318  91 ----LCFISIDRHCAICDPLLYPSKFTIR 115
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
33-165 1.36e-04

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 42.78  E-value: 1.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  33 LCSLY----LIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPkmmaifwfnsttIQFDACLIQMFAI-H 107
Cdd:cd15393   3 LSILYgiisLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIP------------FQFQAALLQRWVLpR 70
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47577687 108 SLSGMESTV-----------LLAMAFDRYVAICHPLRHATVltlPRVAKIGMaAVVRGAALMAPLPVFI 165
Cdd:cd15393  71 FMCPFCPFVqvlsvnvsvftLTVIAVDRYRAVIHPLKARCS---KKSAKIII-LIIWILALLVALPVAL 135
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
36-165 1.40e-04

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 42.73  E-value: 1.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILIS-----TSSMPKMMAIFW-FNSTTIQFDAcLIQMFAIhSL 109
Cdd:cd15392  10 IFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAvfcvpFSFIALLILQYWpFGEFMCPVVN-YLQAVSV-FV 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47577687 110 SgmeSTVLLAMAFDRYVAICHPLRhatvltlPRVAK---IGMAAVVRGAALMAPLPVFI 165
Cdd:cd15392  88 S---AFTLVAISIDRYVAIMWPLR-------PRMTKrqaLLLIAVIWIFALATALPIAI 136
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
36-182 1.41e-04

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 42.88  E-value: 1.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15202  10 IIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVSAY 89
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47577687 116 VLLAMAFDRYVAICHPLRhatvltlPRVAKIGMAAVVRGAALMA-----PLPVFIKRLPFCRSNILSHSYCL 182
Cdd:cd15202  90 TLTAIAVDRYQAIMHPLK-------PRISKTKAKFIIAVIWTLAlafalPHAICSKLETFKYSEDIVRSLCL 154
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
34-163 2.47e-04

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 41.93  E-value: 2.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  34 CSLYLIAVLGNL-TIIYIVRTEHrLHEPMYIFLCMLSGLDILISTSSMPKMMAIFW------FNSTTIQFDACLIQMFAI 106
Cdd:cd15134   8 GIIFVTGVVGNLcTCIVIARNRS-MHTATNYYLFSLAVSDLLLLILGLPFELYTIWqqypwvFGEVFCKLRAFLSEMSSY 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47577687 107 HSLsgmesTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPV 163
Cdd:cd15134  87 ASV-----LTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAI 138
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
36-181 2.62e-04

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 41.83  E-value: 2.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMP-----KMMAIFWFNSTTIQFDACLIQMFAIHSLs 110
Cdd:cd15321  16 LILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPfslanELMGYWYFRKTWCEIYLALDVLFCTSSI- 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 111 gmesTVLLAMAFDRYVAICHPLRHATVLTlPRVAKIGMAAVVRGAALMAPLPVFIKR--------LPFCRSN-----ILS 177
Cdd:cd15321  95 ----VHLCAISLDRYWSVSRAIEYNSKRT-PRRIKCIILIVWLIAAVISLPPLIYKGkqkdeqggLPQCKLNeeawyILS 169

                ....
gi 47577687 178 HSYC 181
Cdd:cd15321 170 SSIG 173
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
39-146 2.97e-04

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 41.69  E-value: 2.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  39 IAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFN--------STTIQFDACLIQMFAIHSLS 110
Cdd:cd15350  13 VGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADmgylnrrgPFETKLDDIMDSLFCLSLLG 92
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 47577687 111 GMEStvLLAMAFDRYVAICHPLRHATVLTLPRVAKI 146
Cdd:cd15350  93 SIFS--ILAIAADRYITIFHALRYHNIMTMRRTLVI 126
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
38-146 4.52e-04

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 41.46  E-value: 4.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  38 LIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAI---FWFNSTTIQFDACLIQMFAIHSLSGmes 114
Cdd:cd15068  12 VLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIstgFCAACHGCLFIACFVLVLTQSSIFS--- 88
                        90       100       110
                ....*....|....*....|....*....|..
gi 47577687 115 tvLLAMAFDRYVAICHPLRHATVLTLPRVAKI 146
Cdd:cd15068  89 --LLAIAIDRYIAIRIPLRYNGLVTGTRAKGI 118
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
38-141 5.27e-04

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 40.89  E-value: 5.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  38 LIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMM-----AIFWFNSTTIQFDACLIQMFAIHSLSGm 112
Cdd:cd15317  12 LITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMirtveTCWYFGDLFCKFHTGLDLLLCTTSIFH- 90
                        90       100
                ....*....|....*....|....*....
gi 47577687 113 estvLLAMAFDRYVAICHPLRHATVLTLP 141
Cdd:cd15317  91 ----LCFIAIDRYYAVCDPLRYPSKITVQ 115
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
38-146 5.61e-04

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 40.83  E-value: 5.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  38 LIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSS-MPKMMAIFWFNSTTIQFDA-CLIQMFAIHSLSGMEST 115
Cdd:cd14995  12 GVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAgLPNEIESLLGPDSWIYGYAgCLLITYLQYLGINASSL 91
                        90       100       110
                ....*....|....*....|....*....|.
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTLPRVAKI 146
Cdd:cd14995  92 SITAFTIERYIAICHPMKAQFICTVSRAKKI 122
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
36-165 6.09e-04

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 40.92  E-value: 6.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVR--TEHRLHEPMYIF------LCMLSGLDILISTSSMPKMmaIFWFNSTTIQFDACLIQMFAih 107
Cdd:cd15094  10 ICIVGLVGNGLVIYVVLryAKMKTVTNLYILnlavadECFLIGLPFLIVTMILKYW--PFGAAMCKIYMVLTSINQFT-- 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 47577687 108 slsgmESTVLLAMAFDRYVAICHPLRHATVLTlPRVAKIgMAAVVRGAALMAPLPVFI 165
Cdd:cd15094  86 -----SSFTLTVMSADRYLAVCHPIRSMRYRT-PFIAKV-VCATTWSISFLVMLPIIL 136
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
33-163 6.70e-04

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 40.59  E-value: 6.70e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  33 LCSLY-LIAVLGNLTIIYIVRTEHRLH-EPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTtiqfDACLIQMFAIHSLS 110
Cdd:cd15341   6 LCTLCgLLCILENVAVLYLILSSPKLRrKPSYLFIGSLALADFLASVVFACSFVDFHVFHGV----DSSAIFLLKLGGVT 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47577687 111 gMESTV----LLAMAFDRYVAICHPLRHATVLTLPRvAKIGMAAVVRGAALMAPLPV 163
Cdd:cd15341  82 -MSFTAslgsLLLMAFDRYVCIYYPSEYKALVTRKR-ALVALAVMWVLTALIAYLPL 136
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
36-304 7.23e-04

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 40.34  E-value: 7.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACliQMFAIHSLSGMEST 115
Cdd:cd15001   9 TFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLC--KAVAYLQLLSFICS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 V--LLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFCRSNILSHSYCLHqdvmklACAD 193
Cdd:cd15001  87 VltLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHCQK------AWPS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 194 IRVNIIYGLIVIISAIGLDSLFISFSYllILKTVLGLTReaqakafgTCVSHVCAVFIFYVPFIGLSMVHRF---SKRHD 270
Cdd:cd15001 161 TLYSRLYVVYLAIVIFFIPLIVMTFAY--ARDTRKQVIK--------MLISVVVLFAVCWGPLLIDNLLVSFdviSTLHT 230
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577687 271 SLLPVIMANIYLLV--PPVLNPIVYGVKTKEIRQRI 304
Cdd:cd15001 231 QALKYMRIAFHLLSyaNSCINPIIYAFMSKNFRSSF 266
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
31-164 7.30e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 40.90  E-value: 7.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  31 FPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMA-----IFW-FNSTTIQFDACLIQMF 104
Cdd:cd15005   5 TTLGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMAsvrhgSGWiYGALSCKVIAFLAVLF 84
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47577687 105 AIHSlsgmeSTVLLAMAFDRYVAICHPLRHATVLTLPR-VAKIGMAAVVRGAalMAPLPVF 164
Cdd:cd15005  85 CFHS-----AFTLFCIAVTRYMAIAHHRFYAKRMTFWTcLAVICMAWTLSVA--MAFPPVF 138
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
36-167 8.01e-04

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 40.31  E-value: 8.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMP-----KMMAIFWFNSTTIQFDACLIQMFAIHSLs 110
Cdd:cd15322  10 LMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPfslanEVMGYWYFGKVWCEIYLALDVLFCTSSI- 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47577687 111 gmesTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKR 167
Cdd:cd15322  89 ----VHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEK 141
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
38-164 1.01e-03

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 40.22  E-value: 1.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  38 LIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPkmMAIFWFNSTTIQFDACLIQMFAIHSLSGMESTVL 117
Cdd:cd15071  12 LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAIIINIGPQTEFYSCLMVACPVLILTQSSILAL 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 47577687 118 LAMAFDRYVAICHPLRHATVLTlPRVAKIGMAAVVRGAALMAPLPVF 164
Cdd:cd15071  90 LAIAVDRYLRVKIPTRYKSVVT-PRRAAVAIAGCWILSFLVGLTPMF 135
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
38-302 1.02e-03

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 40.09  E-value: 1.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  38 LIAVLGNLTIIYIVRTEHRLHEPMYI--FLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAIHSLSGMEST 115
Cdd:cd15002  11 LLGFAGNLMVIGILLNNARKGKPSLIdsLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHACMAAKSF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 116 VLLAMAFDRYVAICHPLRhaTVLTLPRVAKiGMAAVVRGAALMAPLPVFIkrlpFCRSNILSHSYCLHQDVMKLACADIr 195
Cdd:cd15002  91 TIAVLAKACYMYVVNPTK--QVTIKQRRIT-AVVASIWVPACLLPLPQWL----FRTVKQSEGVYLCILCIPPLAHEFM- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 196 vnIIYGLIVIISAIGLDSLFISFSYLLI---LKTVLGLTREAQAKAFGTCVSH-----VCAVFIFYVPFIG--LSMVHRf 265
Cdd:cd15002 163 --SAFVKLYPLFVFCLPLTFALFYFWRAygqCQRRGTKTQNLRNQIRSRKLTHmllsvVLAFTILWLPEWVawLWLIHI- 239
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577687 266 SKRHDSLLPVIMANIYLLVP--PVLNPIVYGVKTKEIRQ 302
Cdd:cd15002 240 KSSGSSPPQLFNVLAQLLAFsiSSVNPIIFLLMSEEFRE 278
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
29-151 1.08e-03

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 40.03  E-value: 1.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  29 LAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIqFDACLIQMFaiHS 108
Cdd:cd15067   2 LGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGYWL-FGRDWCDVW--HS 78
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 47577687 109 LSGMESTV----LLAMAFDRYVAICHPLRHATVLTlPRVAKIGMAAV 151
Cdd:cd15067  79 FDVLASTAsilnLCVISLDRYWAITDPISYPSRMT-KRRALIMIALV 124
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
26-301 1.18e-03

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 40.02  E-value: 1.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  26 QFWLAFpLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMP-----KMMAIFWFNSTTIqfdaCL 100
Cdd:cd15053   1 NYWALF-LLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPfavyvEVNGGKWYLGPIL----CD 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 101 IQMFAIHSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLPFcrsnilshsy 180
Cdd:cd15053  76 IYIAMDVMCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPY---------- 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 181 clhqdvmklacADIRVNIIY-GLIVIISAIGldSLFISFSYLLIL--KTVLGLTREAQAKafgTCVSHVCAVFIF-YVPF 256
Cdd:cd15053 146 -----------RDPEECRFYnPDFIIYSSIS--SFYIPCIVMLLLyyRIFRALRREKKAT---KTLAIVLGVFLFcWLPF 209
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 47577687 257 IGLSMVHRFSKRHDSLLPVIMANIYLL------VPPVLNPIVYGVKTKEIR 301
Cdd:cd15053 210 FTLNILNAICPKLQNQSCHVGPALFSLttwlgyVNSFLNPIIYTIFNIEFR 260
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
27-309 1.39e-03

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 39.55  E-value: 1.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  27 FWLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFAI 106
Cdd:cd15299   4 VLIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSID 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 107 HSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVA-KIGMAAVVrGAALMAPLPVFIKRLPFCRSNILSHSYC--LH 183
Cdd:cd15299  84 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGvMIGLAWVI-SFVLWAPAILFWQYFVGKRTVPPDECFIqfLS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 184 QDVMKLACAdirvniiygliviISAIGLDSLFISFSYLLILKTVLgltreAQAKAFGTCVSHVCAVFIFYVPFIGLSMVH 263
Cdd:cd15299 163 EPIITFGTA-------------IAAFYLPVTIMTILYWRIYKETI-----KEKKAAQTLSAILLAFIITWTPYNIMVLVN 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 47577687 264 RFSkrhDSLLPVIMANI-YLL--VPPVLNPIVYGVKTKEIRQRILRLFL 309
Cdd:cd15299 225 TFC---DSCIPKTYWNLgYWLcyINSTVNPVCYALCNKTFRTTFKMLLL 270
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
28-209 1.42e-03

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 39.74  E-value: 1.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  28 WLAFPLCSLYLIAVLGNL-TIIYIVRTEhRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMfAI 106
Cdd:cd15058   2 GLLLLLALIILAIVVGNLlVIIAIARTS-RLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWT-SV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 107 HSLSGMEST-VLLAMAFDRYVAICHPLRHATVLTLPRvAKIGMAAVVRGAALMAPLPVFikrLPFCRSNILSHSYClHQD 185
Cdd:cd15058  80 DVLCVTASIeTLCVIAVDRYIAITRPLRYQVLLTKRR-ARVIVCVVWIVSALVSFVPIM---NQWWRANDPEANDC-YQD 154
                       170       180
                ....*....|....*....|....
gi 47577687 186 VmklACADIRVNIIYgliVIISAI 209
Cdd:cd15058 155 P---TCCDFRTNMAY---AIASSV 172
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
38-164 1.47e-03

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 39.61  E-value: 1.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  38 LIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTI-QFDACLIQMFaIHSLSGMES-T 115
Cdd:cd15337  12 ILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGFPLKTISSFNKKWIwGKVACELYGF-AGGIFGFMSiT 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47577687 116 VLLAMAFDRYVAICHPLRHATVLTlPRVAKIGMAAVVRGAALMAPLPVF 164
Cdd:cd15337  91 TLAAISIDRYLVIAKPLEAMKKMT-FKRAFIMIIIIWLWSLLWSIPPFF 138
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
28-135 1.58e-03

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 39.50  E-value: 1.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  28 WLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMP-KMMAIFWFNSTTIQFDACLIQMFAI 106
Cdd:cd15305   2 WPALLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPvSLIAILYDYAWPLPRYLCPIWISLD 81
                        90       100
                ....*....|....*....|....*....
gi 47577687 107 HSLSGMESTVLLAMAFDRYVAICHPLRHA 135
Cdd:cd15305  82 VLFSTASIMHLCAISLDRYVAIRNPIEHS 110
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
36-164 2.41e-03

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 38.87  E-value: 2.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMA--IFWFNSTTIQFdaCLIQMfaihSLSGME 113
Cdd:cd15065   9 IIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVndLLGYWLFGETF--CNIWI----SFDVMC 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47577687 114 STV----LLAMAFDRYVAICHPLRHATVLTlPRVAKIGMAAVVRGAALMAPLPVF 164
Cdd:cd15065  83 STAsilnLCAISLDRYIHIKKPLKYERWMT-TRRALVVIASVWILSALISFLPIH 136
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
28-164 2.55e-03

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 38.80  E-value: 2.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  28 WLAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMA-IFW----FNSTTIQFDACLIQ 102
Cdd:cd15074   2 IIGIYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIIsAFAhrwlFGDIGCVFYGFCGF 81
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47577687 103 MFAIHSLSgmestVLLAMAFDRYVAICHPlRHATVLTLPRVAkIGMAAVVRGAALMAPLPVF 164
Cdd:cd15074  82 LFGCCSIN-----TLTAISIYRYLKICHP-PYGPKLSRRHVC-IVIVAIWLYALFWAVAPLV 136
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
36-169 3.15e-03

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 38.38  E-value: 3.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMP-----KMMAIFWFNSTTIQFDACLIQMFAIHSLs 110
Cdd:cd15323  10 LIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPfslanELMGYWYFGQVWCNIYLALDVLFCTSSI- 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47577687 111 gmesTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAALMAPLPVFIKRLP 169
Cdd:cd15323  89 ----VHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDP 143
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
33-133 3.44e-03

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 38.63  E-value: 3.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  33 LCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILIST-SSMPKMMaifWfnSTTIQF---DACLIQMFAIHS 108
Cdd:cd15386   7 LAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfQVLPQLI---W--EITYRFqgpDLLCRAVKYLQV 81
                        90       100
                ....*....|....*....|....*.
gi 47577687 109 LSGMEST-VLLAMAFDRYVAICHPLR 133
Cdd:cd15386  82 LSMFASTyMLIMMTVDRYIAVCHPLR 107
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
36-164 4.09e-03

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 38.20  E-value: 4.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEpmYIFLCMLSGLDILISTSSMPKMM--AIFWFNSTTIQFDACLIQMFAIHSLSGME 113
Cdd:cd15220   9 LDLTALVGNTAVMVVIAKTPHLRK--FAFVCHLCVVDLLAALLLMPLGIlsSSPFFLGVVFGEAECRVYIFLSVCLVSAS 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 47577687 114 STVLLAMAFDRYVAICHPLRHATVLTLPRVAKIgMAAVVRGAALMAPLPVF 164
Cdd:cd15220  87 ILTISAISVERYYYIVHPMRYEVKMTIGLVAAV-LVGVWVKALLLGLLPVL 136
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
31-162 4.12e-03

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 38.28  E-value: 4.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  31 FPLCSLYL----IAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFW------FNSTTIQFDACL 100
Cdd:cd15133   1 FPVCLTYLlifvVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYELWqnypflLGSGGCYFKTFL 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47577687 101 IQMFAIHSLSGMEstvllAMAFDRYVAICHPLRHATVLTLPRVAKIgmAAVVRGAALMAPLP 162
Cdd:cd15133  81 FETVCLASILNVT-----ALSVERYIAVVHPLAARTCSTRPRVTRV--LGCVWGVSMLCALP 135
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
29-134 4.65e-03

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 37.97  E-value: 4.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  29 LAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMFaIHS 108
Cdd:cd15401   3 LAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGF-LMG 81
                        90       100
                ....*....|....*....|....*..
gi 47577687 109 LSGMESTV-LLAMAFDRYVAICHPLRH 134
Cdd:cd15401  82 LSVIGSVFnITAIAINRYCYICHSLRY 108
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
29-142 5.10e-03

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 37.95  E-value: 5.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  29 LAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLIQMfAIHS 108
Cdd:cd15326   3 LGLVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWA-AVDV 81
                        90       100       110
                ....*....|....*....|....*....|....*
gi 47577687 109 LSGMESTV-LLAMAFDRYVAICHPLRHATVLTLPR 142
Cdd:cd15326  82 LCCTASILsLCAISIDRYIGVRHSLQYPTIVTRKR 116
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
29-132 5.41e-03

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 37.94  E-value: 5.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  29 LAFPLCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDIListssMPKMMAIFWFNS--TTIQFDACLIQMFA- 105
Cdd:cd15079   3 LGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFL-----MMIKMPIFIYNSfyEGWALGPLGCQIYAf 77
                        90       100
                ....*....|....*....|....*...
gi 47577687 106 IHSLSGMESTVLLAM-AFDRYVAICHPL 132
Cdd:cd15079  78 LGSLSGIGSIWTNAAiAYDRYNVIVKPL 105
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
34-223 5.56e-03

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 37.97  E-value: 5.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  34 CSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMP-KMMAIFWFNSTtiqFDACLIQMFA-IHSLSG 111
Cdd:cd15203   8 GLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPfTLIYTLTKNWP---FGSILCKLVPsLQGVSI 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687 112 MESTV-LLAMAFDRYVAICHPLRhaTVLTlPRVAKIGMAAVVRGAALMApLPVFIKR----LPFCRSNIlSHSYCLHQdv 186
Cdd:cd15203  85 FVSTLtLTAIAIDRYQLIVYPTR--PRMS-KRHALLIIALIWILSLLLS-LPLAIFQelsdVPIEILPY-CGYFCTES-- 157
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 47577687 187 mklaCADIRVNIIYGLIVIISAIGLDSLFISFSYLLI 223
Cdd:cd15203 158 ----WPSSSSRLIYTISVLVLQFVIPLLIISFCYFRI 190
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
36-146 6.76e-03

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 37.84  E-value: 6.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  36 LYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILISTSSMP----KMMAIFWFNSTTIQFDACLIQMFAIHSlsg 111
Cdd:cd15205  10 IFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPftllQNISSNWLGGAFMCKMVPFVQSTAVVT--- 86
                        90       100       110
                ....*....|....*....|....*....|....*
gi 47577687 112 mESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKI 146
Cdd:cd15205  87 -SILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTM 120
7tmA_GPR142 cd15129
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G ...
45-164 6.93e-03

G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320257 [Multi-domain]  Cd Length: 270  Bit Score: 37.45  E-value: 6.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  45 LTIIYIVRTEHRLHEPMYIFLCMLSGLDILIstssmpKMMAIFW-FNSTTIQFDACLIQMFaIHSLSGME---------S 114
Cdd:cd15129  20 LTAVALSRLAVRTKKSSYYYLLALTASDILT------QVFIIFVgFILQTAILAREVPHAL-IHTVSVLEfaanhasiwI 92
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47577687 115 TVLLAMafDRYVAICHPLRHATVLTLPRVAKIgmAAVVRGAALMAPLPVF 164
Cdd:cd15129  93 TVLLTV--DRYVALCHPLRYRAVSYPERTRRI--IAAVFVAALATGIPFY 138
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
33-133 7.73e-03

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 37.49  E-value: 7.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577687  33 LCSLYLIAVLGNLTIIYIVRTEHRLHEPMYIFLCMLSGLDILIST-SSMPKMMAIFWFNSTTIQFDACLIQMFAIhslSG 111
Cdd:cd15387   7 LALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfQVLPQLIWDITFRFYGPDFLCRLVKYLQV---VG 83
                        90       100
                ....*....|....*....|....
gi 47577687 112 M--ESTVLLAMAFDRYVAICHPLR 133
Cdd:cd15387  84 MfaSTYMLLLMSIDRCLAICQPLR 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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