first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726  97 RRDYYDDFLQRLLEQGIHSDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTG 176
Cdd:cd18295   2 RRDYYDEFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTG 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 54400726 177 RLDIGVEHVSDCERLAKQCQLWDLLDDLEAKCEKVSEF 214
Cdd:cd18295  82 RLEIHVDDVEDCKRLAKQCRLEELIEELEAKCKKVREF 119

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 54400726 376 LEEDSVVGVWRIAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVREEAAAVAARQETDSIPLVDDIRFHV 447
Cdd:cd18497   1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELVREDAASVKNRQETDSIPIIDDIRYHL 72

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726  97 RRDYYDDFLQRLLEQGIHSDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTG 176
Cdd:cd18295   2 RRDYYDEFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTG 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 54400726 177 RLDIGVEHVSDCERLAKQCQLWDLLDDLEAKCEKVSEF 214
Cdd:cd18295  82 RLEIHVDDVEDCKRLAKQCRLEELIEELEAKCKKVREF 119

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 54400726 376 LEEDSVVGVWRIAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVREEAAAVAARQETDSIPLVDDIRFHV 447
Cdd:cd18497   1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELVREDAASVKNRQETDSIPIIDDIRYHL 72

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726    273 DICFRVADSSFLCHKAFFCGRSDYFRALLDDHFRESEEPVasgdppvVTLHDISPDIFTHVLYYVYSDHTELPPELAYDV 352
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSE-------IYLDDVSPEDFRALLNFLYTGKLDLPEENVEEL 73

                           90       100
                   ....*....|....*....|....
gi 54400726    353 LSVADMYLLPGLKRLCGRSLAQLL 376
Cdd:smart00225  74 LELADYLQIPGLVELCEEFLLKLL 97

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726    116 DVVFVVHGKPFRAHRCILGARSTYFANMLDTKWK--GKSVVVLRHplINPVAFGALLQYLYTGRLDIGVEHVSDCERLAK 193
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDD--VSPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                           90
                   ....*....|....*..
gi 54400726    194 QCQLWDLLDDLEAKCEK 210
Cdd:smart00225  79 YLQIPGLVELCEEFLLK 95

Ankyrin repeats (3 copies);

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726     6 LFASCRKGDVGRVRYLLEQRDVEVNVRDKwdsTPLYYACLCGHEELVRYLLANGARCEAN 65
Cdd:pfam12796  34 LHLAAKNGHLEIVKLLLEHADVNLKDNGR---TALHYAARSGHLEIVKLLLEKGADINVK 90

ankyrin repeat protein; Provisional

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 54400726   17 RVRYLLEQrDVEVNVRDKWDSTPLYYACLCGHEELVRYLLANGARCEANTFDGERCL 73
Cdd:PHA03100 174 RVNYLLSY-GVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPL 229

hypothetical protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726  105 LQRLLEQGIHSDVVFVV-HGKPFRAHRCILGARSTYFANMLDTKWKGKSVVV-LRHPLINPVAFGALLQYLYTgrldigv 182
Cdd:PHA02713  16 ISNLLDDDILCDVIITIgDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLVTrVNLQMFDKDAVKNIVQYLYN------- 88

                         90       100
                 ....*....|....*....|....*...
gi 54400726  183 EHVSDCERL-AKQCQLWDLLDDLEAKCE 209
Cdd:PHA02713  89 RHISSMNVIdVLKCADYLLIDDLVTDCE 116

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726  97 RRDYYDDFLQRLLEQGIHSDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTG 176
Cdd:cd18295   2 RRDYYDEFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTG 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 54400726 177 RLDIGVEHVSDCERLAKQCQLWDLLDDLEAKCEKVSEF 214
Cdd:cd18295  82 RLEIHVDDVEDCKRLAKQCRLEELIEELEAKCKKVREF 119

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 54400726 376 LEEDSVVGVWRIAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVREEAAAVAARQETDSIPLVDDIRFHV 447
Cdd:cd18497   1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELVREDAASVKNRQETDSIPIIDDIRYHL 72

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726 269 SSCPDICFRVADSSFLCHKAFFCGRSDYFRALLDDHFRESEEpvasgdpPVVTLHDISPDIFTHVLYYVYSDHTELPPEL 348
Cdd:cd18286  15 GEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNS-------SEITLTGVSHAAVSFVLLFIYGGVLDLPDDV 87

                        90       100
                ....*....|....*....|
gi 54400726 349 -AYDVLSVADMYLLPGLKRL 367
Cdd:cd18286  88 nLGELLSLADMYGLDGLKDV 107

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726   105 LQRLLEQGIHSDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGveh 184
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLISE--- 77

                          90       100
                  ....*....|....*....|....*...
gi 54400726   185 vsdcERLAKQCQLWDLL--DDLEAKCEK 210
Cdd:pfam00651  78 ----ENVDDLLAAADKLqiPSLVDKCEE 101

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726 269 SSCPDICFRVADSSFLCHKAFFCGRSDYFRALLDDHFRESEEPVasgdppvVTLHDISPDIFTHVLYYVYSDHTELPPEL 348
Cdd:cd18314   4 SEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKE-------VTLEDVEPEIFETVLKYMYTGQVTLSEEN 76

                        90       100
                ....*....|....*....|
gi 54400726 349 AYDVLSVADMYLLPGLKRLC 368
Cdd:cd18314  77 VLDLLMLASKYQVPDLEKLC 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726 103 DFLQRLLEQGIHSDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWK--GKSVVVLRHplINPVAFGALLQYLYTGRLDI 180
Cdd:cd18287  11 EDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMResQQSEIELKD--TNAEAFKALLKYIYTGRLTL 88

                        90
                ....*....|....*..
gi 54400726 181 G---VEHVSDCERLAKQ 194
Cdd:cd18287  89 TdlkEDVLLDVLGLAHQ 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726 273 DICFRVADSSFLCHKAFFCGRSDYFRALLDDHFREseepvasGDPPVVTLHDISPDIFTHVLYYVYSDHTE---LPPELA 349
Cdd:cd18297  14 DVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTE-------AQTPVIEIPDIRYDIFQLMMQYLYTGGVEsldVAQDDA 86

                        90       100       110
                ....*....|....*....|....*....|.
gi 54400726 350 YDVLSVADMYLLPGLKRLCGRSLAQLLEEDS 380
Cdd:cd18297  87 LELLRAASFFQLDGLKRHCEILLSQQIDLDN 117

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726 269 SSCPDICFRVADSSFLCHKAFFCGRSDYFRALLDDHFRESEepvASGdppvVTLHDISPDIFTHVLYYVYSDHTELPPEL 348
Cdd:cd18352  11 ATLSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKE---ARD----IEIPNIRWEVFELMMRFIYTGSVDITNDI 83

                        90       100       110
                ....*....|....*....|....*....|...
gi 54400726 349 AYDVLSVADMYLLPGLKRLCGRSLAQLLEEDSV 381
Cdd:cd18352  84 AKDLLRAADQYLLEGLKRLCEYTIAQDLTLENI 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726 273 DICFRVADSSFLCHKAFFCGRSDYFRALLDDHFRESEEpvasgdpPVVTLHDISPDIFTHVLYYVYSDH---TELPPELA 349
Cdd:cd18287  24 DVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQ-------SEIELKDTNAEAFKALLKYIYTGRltlTDLKEDVL 96

                        90
                ....*....|....*.
gi 54400726 350 YDVLSVADMYLLPGLK 365
Cdd:cd18287  97 LDVLGLAHQYGFEELE 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726 115 SDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQ 194
Cdd:cd18297  13 SDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVESLDVAQDDALELLRA 92

                        90
                ....*....|....*
gi 54400726 195 CQLWdLLDDLEAKCE 209
Cdd:cd18297  93 ASFF-QLDGLKRHCE 106

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726 115 SDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWKGKSV--VVLRHplINPVAFGALLQYLYTGRLDIGVEHVSDCERLA 192
Cdd:cd18314   7 SDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLkeVTLED--VEPEIFETVLKYMYTGQVTLSEENVLDLLMLA 84

                ....*....
gi 54400726 193 KQCQLWDLL 201
Cdd:cd18314  85 SKYQVPDLE 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726 273 DICFRVADSSFLCHKAFFCGRSDYFRALLDDHFRESEEpvasgdpPVVTLHDISPDIFTHVLYYVY------------SD 340
Cdd:cd18280  16 DVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENE-------GEIVIEDVEPPVFKALLHFIYkdelpddvepagSD 88

                        90       100       110
                ....*....|....*....|....*....|..
gi 54400726 341 HTELPPELAYDVLSVADMYLLPGLKRLCGRSL 372
Cdd:cd18280  89 SSSLDTTMAQHLLAAADRYALERLRLLCESRL 120

Ankyrin repeat [Signal transduction mechanisms];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726   6 LFASCRKGDVGRVRYLLEqRDVEVNVRDKWDSTPLYYACLCGHEELVRYLLANGARCEANTFDGERCLYGALSDPIRRAL 85
Cdd:COG0666 157 LHLAAANGNLEIVKLLLE-AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235

                        90       100       110
                ....*....|....*....|....*....|...
gi 54400726  86 RDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVV 118
Cdd:COG0666 236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIV 268

Ankyrin repeat [Signal transduction mechanisms];

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 54400726   1 MDTSDLFASCRKGDVGRVRYLLEQrDVEVNVRDKWDSTPLYYACLCGHEELVRYLLANGARCEANTFDGERCLYGA 76
Cdd:COG0666  86 GGNTLLHAAARNGDLEIVKLLLEA-GADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726 273 DICFRVADSSFLCHKAFFCGRSDYFRALLDDHFRESEEpvasgdpPVVTLHDISPDIFTHVLYYVYSDHTELPPEL-AYD 351
Cdd:cd18300  11 DVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSA-------KEVELPGVSKETFLALLEYLYTDQAPILEDGdCVG 83

                        90
                ....*....|....*..
gi 54400726 352 VLSVADMYLLPGLKRLC 368
Cdd:cd18300  84 LIVLANRLCLPRLVALC 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726 253 LRGDLGEL---PFpcpdgFSSCpdiCFRVADSSFLCHKAFFCGRSDYFRALLDDHFRESeepvaSGDPpvVTLHDISPDI 329
Cdd:cd18344  10 LTDDLGELwenSL-----FTDC---CLLVAGHEFRAHKAILAARSPVFRAMFEHEMEER-----LKNP--IEIHDLDPQV 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 54400726 330 FTHVLYYVYsdhTELPPEL-----AYDVLSVADMYLLPGLKRLCGRSLAQLL 376
Cdd:cd18344  75 FKEMMGFIY---TGKAPHLhshsmACDVLAAADKYGLEGLKVLCEDALCRNL 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726 273 DICFRVADSSFLCHKAFFCGRSDYFRALLDDHFRESEEPVasgdppvVTLHDISPDIFTHVLYYVYSDHTELPPELAYDV 352
Cdd:cd18256  22 DVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDV-------VQIHGVEPDIFHILLDFIYTGVVEVTVSNVQEL 94

                        90       100       110
                ....*....|....*....|....*....|.
gi 54400726 353 LSVADMYLLPGLKRLCGRSLAQLLEEDSVVG 383
Cdd:cd18256  95 LVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125

Ankyrin repeats (3 copies);

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726     6 LFASCRKGDVGRVRYLLEQRDVEVNVRDKwdsTPLYYACLCGHEELVRYLLANGARCEAN 65
Cdd:pfam12796  34 LHLAAKNGHLEIVKLLLEHADVNLKDNGR---TALHYAARSGHLEIVKLLLEKGADINVK 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726 273 DICFRVADSSFLCHKAFFCGRSDYFRALLDDHFRESEEPVasgdppvVTLHDISPDIFTHVLYYVYSDHTELPPELAYDV 352
Cdd:cd18240  19 DVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKV-------YKIPGVSPEMMELIIEYAYTRTVPITAENVEEL 91

                        90
                ....*....|....*.
gi 54400726 353 LSVADMYLLPGLKRLC 368
Cdd:cd18240  92 LPAADQFNIMGIVKAC 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726 105 LQRLLEQGIHSDVVFVVHGKPFRAHRCILGARSTYFANML--DTKWKGKSVVVLRHplINPVAFGALLQYLYTGRLDIGV 182
Cdd:cd18242  12 MNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFtsEMSEKGKSEVELQG--LTASTMEILLDFVYTETVHVTV 89

                ....*
gi 54400726 183 EHVSD 187
Cdd:cd18242  90 ENVQE 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400726 273 DICFRVADSSFLCHKAFFCGRSDYFRALLDDHFREseepvasGDPPVVTLHDISPDIFTHVLYYVYSDHTELPPELAYDV 352
Cdd:cd18298  14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNE-------DDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPPEDAIGL 86

                        90       100
                ....*....|....*....|..
gi 54400726 353 LSVADMYLLPGLKRLCGRSLAQ 374
Cdd:cd18298  87 LDLANSYCEERLKKLCEDIIKQ 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 54400726 105 LQRLLEQGIHSDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDI 180
Cdd:cd18331  15 LNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFNILLDFMYTSRLNL 90