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Conserved domains on  [gi|55742664|ref|NP_001007014|]
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glycoprotein hormone beta-5 precursor [Rattus norvegicus]

Protein Classification

GHB_like domain-containing protein( domain architecture ID 10049220)

GHB_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GHB_like cd00069
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 35-128 4.11e-41

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


:

Pssm-ID: 200450  Cd Length: 96  Bit Score: 131.64  E-value: 4.11e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742664  35 CAVREFTFVAKKPGCR-GLRITTDACWGRCETWEKPILEPPYIEAYHRVCTYNETRQVTVKLPNCAPGVDPFYTYPMAVR 113
Cdd:cd00069   1 CHPRNYTIAVEKEGCGvCLAINTTICAGRCDTRDPVYKSPPYKPSHQPVCTYDEWRYETVRLPGCPPGVDPTYTYPVALS 80

                        90
                ....*....|....*
gi 55742664 114 CDCGACSTATTECET 128
Cdd:cd00069  81 CRCGLCNTDTTDCTR 95
 
Name Accession Description Interval E-value
GHB_like cd00069
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 35-128 4.11e-41

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


Pssm-ID: 200450  Cd Length: 96  Bit Score: 131.64  E-value: 4.11e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742664  35 CAVREFTFVAKKPGCR-GLRITTDACWGRCETWEKPILEPPYIEAYHRVCTYNETRQVTVKLPNCAPGVDPFYTYPMAVR 113
Cdd:cd00069   1 CHPRNYTIAVEKEGCGvCLAINTTICAGRCDTRDPVYKSPPYKPSHQPVCTYDEWRYETVRLPGCPPGVDPTYTYPVALS 80

                        90
                ....*....|....*
gi 55742664 114 CDCGACSTATTECET 128
Cdd:cd00069  81 CRCGLCNTDTTDCTR 95
GHB smart00068
Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones ...
 34-126 1.32e-19

Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology.


Pssm-ID: 214502  Cd Length: 107  Bit Score: 77.32  E-value: 1.32e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742664     34 GCAVREFTFVAKKPGCRG-LRITTDACWGRCETwEKPILEPPYIEAYHRVCTYNETRQVTVKLPNCAPGVDPFYTYPMAV 112
Cdd:smart00068   4 GCRPTNATIAVEKEECPVcITINTTICAGYCYT-RDPVYKSPLPPLPQRVCTYRELRYETVRLPGCPPGVDPVVTYPVAL 82

                           90
                   ....*....|....
gi 55742664    113 RCDCGACSTATTEC 126
Cdd:smart00068  83 SCHCGKCNTDTTDC 96
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 33-127 6.40e-15

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 65.50  E-value: 6.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742664    33 VGCAVREFTFVAKKPGCRG-LRITTDACWGRCETwEKPILEPPYIEAYHRVCTYNETRQVTVKLPNCAPGVDPFYTYPMA 111
Cdd:pfam00007   2 KKCIPTNYTISVEKEGCTScKTINTTICAGYCYT-RDPVYKDGRRAVSQRVCTYRDVTYETVVLPGCPPGVDPTVTYPVA 80

                          90
                  ....*....|....*.
gi 55742664   112 VRCDCGACSTATTECE 127
Cdd:pfam00007  81 LSCHCGNCPTDNSDCT 96
 
Name Accession Description Interval E-value
GHB_like cd00069
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 35-128 4.11e-41

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


Pssm-ID: 200450  Cd Length: 96  Bit Score: 131.64  E-value: 4.11e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742664  35 CAVREFTFVAKKPGCR-GLRITTDACWGRCETWEKPILEPPYIEAYHRVCTYNETRQVTVKLPNCAPGVDPFYTYPMAVR 113
Cdd:cd00069   1 CHPRNYTIAVEKEGCGvCLAINTTICAGRCDTRDPVYKSPPYKPSHQPVCTYDEWRYETVRLPGCPPGVDPTYTYPVALS 80

                        90
                ....*....|....*
gi 55742664 114 CDCGACSTATTECET 128
Cdd:cd00069  81 CRCGLCNTDTTDCTR 95
GHB smart00068
Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones ...
 34-126 1.32e-19

Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology.


Pssm-ID: 214502  Cd Length: 107  Bit Score: 77.32  E-value: 1.32e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742664     34 GCAVREFTFVAKKPGCRG-LRITTDACWGRCETwEKPILEPPYIEAYHRVCTYNETRQVTVKLPNCAPGVDPFYTYPMAV 112
Cdd:smart00068   4 GCRPTNATIAVEKEECPVcITINTTICAGYCYT-RDPVYKSPLPPLPQRVCTYRELRYETVRLPGCPPGVDPVVTYPVAL 82

                           90
                   ....*....|....
gi 55742664    113 RCDCGACSTATTEC 126
Cdd:smart00068  83 SCHCGKCNTDTTDC 96
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 33-127 6.40e-15

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 65.50  E-value: 6.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742664    33 VGCAVREFTFVAKKPGCRG-LRITTDACWGRCETwEKPILEPPYIEAYHRVCTYNETRQVTVKLPNCAPGVDPFYTYPMA 111
Cdd:pfam00007   2 KKCIPTNYTISVEKEGCTScKTINTTICAGYCYT-RDPVYKDGRRAVSQRVCTYRDVTYETVVLPGCPPGVDPTVTYPVA 80

                          90
                  ....*....|....*.
gi 55742664   112 VRCDCGACSTATTECE 127
Cdd:pfam00007  81 LSCHCGNCPTDNSDCT 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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