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Conserved domains on  [gi|56090230|ref|NP_001007617|]
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WD repeat and SOCS box-containing protein 2 isoform 1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-360 2.94e-63

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 208.23  E-value: 2.94e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230  30 WSVAFSPDGSWFAWSQGHCVVKLvpWPLEEQFIPKGFEAKSRSskndskgrgslkektldcgqiVWGLAFSPwpsppsrk 109
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRL--WDLATGLLLRTLTGHTGA---------------------VRSVAFSP-------- 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 110 lwlrhhpqvpdvSCLILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPNGSLiLVSASRDKTLRIWDLNKhGKQ 189
Cdd:COG2319 131 ------------DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLAT-GKL 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 190 IQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPY 269
Cdd:COG2319 197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 270 TGERLRSLHHtqleapvddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVA-FAPMTNGLCC-TFFPHGGV 347
Cdd:COG2319 277 TGELLRTLTG------------HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGHTGAVRSvAFSPDGKT 344

                       330
                ....*....|...
gi 56090230 348 IATGTRDGHVQFW 360
Cdd:COG2319 345 LASGSDDGTVRLW 357
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 364-402 1.15e-20

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239702  Cd Length: 39  Bit Score: 84.01  E-value: 1.15e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 56090230 364 RVLSSLKHLCRKALRRFLTTYQVLALPIPKKMKDFLTYR 402
Cdd:cd03733   1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-360 2.94e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 208.23  E-value: 2.94e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230  30 WSVAFSPDGSWFAWSQGHCVVKLvpWPLEEQFIPKGFEAKSRSskndskgrgslkektldcgqiVWGLAFSPwpsppsrk 109
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRL--WDLATGLLLRTLTGHTGA---------------------VRSVAFSP-------- 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 110 lwlrhhpqvpdvSCLILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPNGSLiLVSASRDKTLRIWDLNKhGKQ 189
Cdd:COG2319 131 ------------DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLAT-GKL 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 190 IQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPY 269
Cdd:COG2319 197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 270 TGERLRSLHHtqleapvddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVA-FAPMTNGLCC-TFFPHGGV 347
Cdd:COG2319 277 TGELLRTLTG------------HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGHTGAVRSvAFSPDGKT 344

                       330
                ....*....|...
gi 56090230 348 IATGTRDGHVQFW 360
Cdd:COG2319 345 LASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 121-360 2.19e-54

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.76  E-value: 2.19e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 121 VSCL-------ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPNGSLiLVSASRDKTLRIWDLNKhGKQIQVL 193
Cdd:cd00200  12 VTCVafspdgkLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLET-GECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 194 SGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGER 273
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 274 LRSLHHtqleapvddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVA-FAPMTNGL-CCTFFPHGGVIATG 351
Cdd:cd00200 170 VATLTG------------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGtLRGHENGVnSVAFSPDGYLLASG 237


                ....*....
gi 56090230 352 TRDGHVQFW 360
Cdd:cd00200 238 SEDGTIRVW 246
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 364-402 1.15e-20

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 84.01  E-value: 1.15e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 56090230 364 RVLSSLKHLCRKALRRFLTTYQVLALPIPKKMKDFLTYR 402
Cdd:cd03733   1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 360-402 6.15e-13

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 62.70  E-value: 6.15e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 56090230    360 WTAPRVLSSLKHLCRKALRRFLTTYQVLALPIPKKMKDFLTYR 402
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
PTZ00421 PTZ00421
coronin; Provisional
 126-308 2.85e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 61.83  E-value: 2.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230  126 LATGLNDGQIKIWEVQT-GLL------LLNLSGHQDVVRDLSFTPNGSLILVSASRDKTLRIWDLNKhGKQIQVLSGHLQ 198
Cdd:PTZ00421  91 LFTASEDGTIMGWGIPEeGLTqnisdpIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER-GKAVEVIKCHSD 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230  199 WVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS-CDFSPDSALLVTASYDTS----VIMWDPytger 273
Cdd:PTZ00421 170 QITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQrCLWAKRKDLIITLGCSKSqqrqIMLWDT----- 244

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 56090230  274 lrslhhTQLEAPVDDSDVHMSSLRSVCFSPEGLYL 308
Cdd:PTZ00421 245 ------RKMASPYSTVDLDQSSALFIPFFDEDTNL 273
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 228-267 8.91e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 8.91e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 56090230    228 SYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWD 267
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
230-267 1.49e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 1.49e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 56090230   230 TLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWD 267
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 368-400 9.42e-06

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 42.15  E-value: 9.42e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 56090230   368 SLKHLCRKALRRFLTTY---QVLALPIPKKMKDFLT 400
Cdd:pfam07525   4 SLQHLCRLAIRRALGKRrlgAIDKLPLPPLLKDYLL 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-360 2.94e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 208.23  E-value: 2.94e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230  30 WSVAFSPDGSWFAWSQGHCVVKLvpWPLEEQFIPKGFEAKSRSskndskgrgslkektldcgqiVWGLAFSPwpsppsrk 109
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRL--WDLATGLLLRTLTGHTGA---------------------VRSVAFSP-------- 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 110 lwlrhhpqvpdvSCLILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPNGSLiLVSASRDKTLRIWDLNKhGKQ 189
Cdd:COG2319 131 ------------DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLAT-GKL 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 190 IQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPY 269
Cdd:COG2319 197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 270 TGERLRSLHHtqleapvddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVA-FAPMTNGLCC-TFFPHGGV 347
Cdd:COG2319 277 TGELLRTLTG------------HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGHTGAVRSvAFSPDGKT 344

                       330
                ....*....|...
gi 56090230 348 IATGTRDGHVQFW 360
Cdd:COG2319 345 LASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
125-370 1.48e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.59  E-value: 1.48e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 125 ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPNGSlILVSASRDKTLRIWDLNKhGKQIQVLSGHLQWVYCCS 204
Cdd:COG2319  92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGK-TLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVA 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 205 ISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLHHtqlea 284
Cdd:COG2319 170 FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG----- 244

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 285 pvddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVAFAPMTNG--LCCTFFPHGGVIATGTRDGHVQFWTA 362
Cdd:COG2319 245 -------HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGgvNSVAFSPDGKLLASGSDDGTVRLWDL 317

                       250
                ....*....|
gi 56090230 363 --PRVLSSLK 370
Cdd:COG2319 318 atGKLLRTLT 327
WD40 COG2319
WD40 repeat [General function prediction only];
10-323 1.40e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 188.20  E-value: 1.40e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230  10 LAELKPGRPHQFDWKSSCETWSVAFSPDGSWFAWSQGHCVVKLvpWPLEEQFIPKGFEAKSRSskndskgrgslkektld 89
Cdd:COG2319 104 LWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL--WDLATGKLLRTLTGHSGA----------------- 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230  90 cgqiVWGLAFSP----------------WPSPPSRKLW-LRHHPQVpdVSCL-------ILATGLNDGQIKIWEVQTGLL 145
Cdd:COG2319 165 ----VTSVAFSPdgkllasgsddgtvrlWDLATGKLLRtLTGHTGA--VRSVafspdgkLLASGSADGTVRLWDLATGKL 238

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 146 LLNLSGHQDVVRDLSFTPNGSLiLVSASRDKTLRIWDLNKhGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWS 225
Cdd:COG2319 239 LRTLTGHSGSVRSVAFSPDGRL-LASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 226 MRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLhhtqleapvddsDVHMSSLRSVCFSPEG 305
Cdd:COG2319 317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL------------TGHTGAVTSVAFSPDG 384

                       330
                ....*....|....*...
gi 56090230 306 LYLATVADDRLLRIWALE 323
Cdd:COG2319 385 RTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 121-360 2.19e-54

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.76  E-value: 2.19e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 121 VSCL-------ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPNGSLiLVSASRDKTLRIWDLNKhGKQIQVL 193
Cdd:cd00200  12 VTCVafspdgkLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLET-GECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 194 SGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGER 273
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 274 LRSLHHtqleapvddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVA-FAPMTNGL-CCTFFPHGGVIATG 351
Cdd:cd00200 170 VATLTG------------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGtLRGHENGVnSVAFSPDGYLLASG 237


                ....*....
gi 56090230 352 TRDGHVQFW 360
Cdd:cd00200 238 SEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 126-360 3.61e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 173.29  E-value: 3.61e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPNGSlILVSASRDKTLRIWDLNKhGKQIQVLSGHLQWVYCCSI 205
Cdd:cd00200  66 LASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAF 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 206 SPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLHhtqleap 285
Cdd:cd00200 144 SPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR------- 216

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56090230 286 vddsdVHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVAFAPMTNG--LCCTFFPHGGVIATGTRDGHVQFW 360
Cdd:cd00200 217 -----GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNsvTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 112-321 7.54e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 167.13  E-value: 7.54e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 112 LRHHPQvpDVSCL-------ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPNGSLIlVSASRDKTLRIWDLN 184
Cdd:cd00200  89 LTGHTS--YVSSVafspdgrILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV-ASSSQDGTIKLWDLR 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 185 KhGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVI 264
Cdd:cd00200 166 T-GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIR 244

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 56090230 265 MWDPYTGERLRSLHHtqleapvddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWA 321
Cdd:cd00200 245 VWDLRTGECVQTLSG------------HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
91-371 9.89e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.39  E-value: 9.89e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230  91 GQIVWGLAFSPWPSPPSRKLWLRHHPQVPDVSC----LILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPNGS 166
Cdd:COG2319  12 ASADLALALLAAALGALLLLLLGLAAAVASLAAspdgARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 167 lILVSASRDKTLRIWDLNkHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCD 246
Cdd:COG2319  92 -LLASASADGTVRLWDLA-TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVA 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 247 FSPDSALLVTASYDTSVIMWDPYTGERLRSLhhtqleapvddsDVHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKA 326
Cdd:COG2319 170 FSPDGKLLASGSDDGTVRLWDLATGKLLRTL------------TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56090230 327 PVAFAPMTNG--LCCTFFPHGGVIATGTRDGHVQFW--TAPRVLSSLKH 371
Cdd:COG2319 238 LLRTLTGHSGsvRSVAFSPDGRLLASGSADGTVRLWdlATGELLRTLTG 286
WD40 COG2319
WD40 repeat [General function prediction only];
30-270 1.29e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.31  E-value: 1.29e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230  30 WSVAFSPDGSWFAWSQGHCVVKLvpWPLEEQFIPKGFEAKSRSskndskgrgslkektldcgqiVWGLAFSPwpsppsrk 109
Cdd:COG2319 208 RSVAFSPDGKLLASGSADGTVRL--WDLATGKLLRTLTGHSGS---------------------VRSVAFSP-------- 256

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 110 lwlrhhpqvpdvSCLILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPNGSLiLVSASRDKTLRIWDLNKhGKQ 189
Cdd:COG2319 257 ------------DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKL-LASGSDDGTVRLWDLAT-GKL 322

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 190 IQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPY 269
Cdd:COG2319 323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402


                .
gi 56090230 270 T 270
Cdd:COG2319 403 T 403
WD40 COG2319
WD40 repeat [General function prediction only];
126-371 7.39e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.33  E-value: 7.39e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPNGsLILVSASRDKTLRIWDLNKhGKQIQVLSGHLQWVYCCSI 205
Cdd:COG2319   9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDG-ARLAAGAGDLTLLLLDAAA-GALLATLLGHTAAVLSVAF 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 206 SPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLHHtqleap 285
Cdd:COG2319  87 SPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG------ 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 286 vddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVA-FAPMTNGL-CCTFFPHGGVIATGTRDGHVQFW--T 361
Cdd:COG2319 161 ------HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGHTGAVrSVAFSPDGKLLASGSADGTVRLWdlA 234

                       250
                ....*....|
gi 56090230 362 APRVLSSLKH 371
Cdd:COG2319 235 TGKLLRTLTG 244
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 190-360 1.56e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.50  E-value: 1.56e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 190 IQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPY 269
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 270 TGERLRSLHHtqleapvddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVAFAPMTNG--LCCTFFPHGGV 347
Cdd:cd00200  82 TGECVRTLTG------------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwvNSVAFSPDGTF 149

                       170
                ....*....|...
gi 56090230 348 IATGTRDGHVQFW 360
Cdd:cd00200 150 VASSSQDGTIKLW 162
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 364-402 1.15e-20

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 84.01  E-value: 1.15e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 56090230 364 RVLSSLKHLCRKALRRFLTTYQVLALPIPKKMKDFLTYR 402
Cdd:cd03733   1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
 364-402 2.46e-19

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 80.71  E-value: 2.46e-19
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 56090230 364 RVLSSLKHLCRKALRRFLTTYQVLALPIPKKMKDFLTYR 402
Cdd:cd03745   1 RVLPSLRHLCRKALRHFLTTYQVLALPIPKKMKEFLTYR 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 231-360 2.45e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 84.69  E-value: 2.45e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 231 LIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLHhtqleapvddsdVHMSSLRSVCFSPEGLYLAT 310
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK------------GHTGPVRDVAASADGTYLAS 68

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 56090230 311 VADDRLLRIWALELKAPVA-FAPMTNG-LCCTFFPHGGVIATGTRDGHVQFW 360
Cdd:cd00200  69 GSSDKTIRLWDLETGECVRtLTGHTSYvSSVAFSPDGRILSSSSRDKTIKVW 120
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 364-403 3.99e-13

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 63.29  E-value: 3.99e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 56090230 364 RVLSSLKHLCRKALRRFLTTYQVLALPIPKKMKDFLTYRT 403
Cdd:cd03746   1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYRT 40
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 360-402 6.15e-13

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 62.70  E-value: 6.15e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 56090230    360 WTAPRVLSSLKHLCRKALRRFLTTYQVLALPIPKKMKDFLTYR 402
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
PTZ00421 PTZ00421
coronin; Provisional
 126-308 2.85e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 61.83  E-value: 2.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230  126 LATGLNDGQIKIWEVQT-GLL------LLNLSGHQDVVRDLSFTPNGSLILVSASRDKTLRIWDLNKhGKQIQVLSGHLQ 198
Cdd:PTZ00421  91 LFTASEDGTIMGWGIPEeGLTqnisdpIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER-GKAVEVIKCHSD 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230  199 WVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS-CDFSPDSALLVTASYDTS----VIMWDPytger 273
Cdd:PTZ00421 170 QITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQrCLWAKRKDLIITLGCSKSqqrqIMLWDT----- 244

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 56090230  274 lrslhhTQLEAPVDDSDVHMSSLRSVCFSPEGLYL 308
Cdd:PTZ00421 245 ------RKMASPYSTVDLDQSSALFIPFFDEDTNL 273
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 368-402 2.38e-09

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 52.47  E-value: 2.38e-09
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 56090230 368 SLKHLCRKALRRFL---TTYQVLALPIPKKMKDFLTYR 402
Cdd:cd03587   4 SLQHLCRLAIRRCLgkrRLDLIDKLPLPPRLKDYLLYK 41
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 367-402 6.71e-08

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 48.36  E-value: 6.71e-08
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 56090230 367 SSLKHLCRKALRRFLTTYQVLALPIPKKMKDFLTYR 402
Cdd:cd03717   4 RSLQHLCRFVIRQCTRRDLIDQLPLPRRLKDYLKEY 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 228-267 8.91e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 8.91e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 56090230    228 SYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWD 267
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
230-267 1.49e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 1.49e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 56090230   230 TLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWD 267
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 367-402 1.78e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 47.02  E-value: 1.78e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 56090230    367 SSLKHLCRKALRRFLttYQVLALPIPKKMKDFLTYR 402
Cdd:smart00969   1 RSLQHLCRLAIRRSL--GGIDKLPLPPRLKDYLLYY 34
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-182 3.15e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 3.15e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 56090230    142 TGLLLLNLSGHQDVVRDLSFTPNGSLiLVSASRDKTLRIWD 182
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 132-267 9.82e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 9.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230  132 DGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPNGSLILVSASRDKTLRIWDLNKhGKQIQVLSGHLQwvYCCSISPDCS- 210
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQ-GVSIGTIKTKAN--ICCVQFPSESg 630

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 56090230  211 -MLCSAAGEKSVFLWSMRSYTL-IRKLEGHQSSVVSCDFSpDSALLVTASYDTSVIMWD 267
Cdd:PLN00181 631 rSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWD 688
WD40 pfam00400
WD domain, G-beta repeat;
143-182 1.03e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.03e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 56090230   143 GLLLLNLSGHQDVVRDLSFTPNGSLiLVSASRDKTLRIWD 182
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 106-226 1.34e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 50.33  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230  106 PSRKLW--LRHHPQVPDvSCLILATGlndGQIKI-WEVQTGLLL--------------LNLSGHQDVVRDLSFTPNGSLI 168
Cdd:PTZ00420  14 PSNNLFddLRICSRVID-SCGIACSS---GFVAVpWEVEGGGLIgairlenqmrkppvIKLKGHTSSILDLQFNPCFSEI 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 56090230  169 LVSASRDKTLRIWDLNKHGKQIQ-------VLSGHLQWVYCCSISP-DCSMLCSAAGEKSVFLWSM 226
Cdd:PTZ00420  90 LASGSEDLTIRVWEIPHNDESVKeikdpqcILKGHKKKISIIDWNPmNYYIMCSSGFDSFVNIWDI 155
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 187-225 9.39e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 9.39e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 56090230    187 GKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWS 225
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 368-400 9.42e-06

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 42.15  E-value: 9.42e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 56090230   368 SLKHLCRKALRRFLTTY---QVLALPIPKKMKDFLT 400
Cdd:pfam07525   4 SLQHLCRLAIRRALGKRrlgAIDKLPLPPLLKDYLL 39
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 368-402 1.44e-05

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 41.71  E-value: 1.44e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 56090230 368 SLKHLCRKALRRFLTTY---QVLALPIPKKMKDFLTYR 402
Cdd:cd03716   5 SLQHLCRLAIRRCLGRRrleLIKKLPLPPRLKDYLLYE 42
PTZ00421 PTZ00421
coronin; Provisional
 115-258 1.54e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 1.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230  115 HPQVPDVscliLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPNGSLiLVSASRDKTLRIWDlNKHGKQIQVLS 194
Cdd:PTZ00421 134 HPSAMNV----LASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSL-LCTTSKDKKLNIID-PRDGTIVSSVE 207

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56090230  195 GHL-----QWVYCCSISPDCSMLCSAAGEKSVFLWSmrsytlIRKLEG-------HQSSVVSCD-FSPDSALLVTAS 258
Cdd:PTZ00421 208 AHAsaksqRCLWAKRKDLIITLGCSKSQQRQIMLWD------TRKMASpystvdlDQSSALFIPfFDEDTNLLYIGS 278
WD40 pfam00400
WD domain, G-beta repeat;
187-225 3.63e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.63e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 56090230   187 GKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWS 225
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 149-268 3.68e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 3.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230  149 LSGHQDVVRDLSFTPNGSLILVSASRDKTLRIWDLNKHGKQ------IQVLSGHLQWVYCCSISPDC-SMLCSAAGEKSV 221
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTqnisdpIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVV 150

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 56090230  222 FLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDP 268
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDP 197
PTZ00420 PTZ00420
coronin; Provisional
 105-199 5.12e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.24  E-value: 5.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230  105 PPSRKLwLRHHPQVPDVS---CL--ILATGLNDGQIKIWE----------VQTGLLLLNlsGHQDVVRDLSFTPNGSLIL 169
Cdd:PTZ00420  65 PPVIKL-KGHTSSILDLQfnpCFseILASGSEDLTIRVWEiphndesvkeIKDPQCILK--GHKKKISIIDWNPMNYYIM 141

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 56090230  170 VSASRDKTLRIWDLNKHGKQIQV-----LSGhLQW 199
Cdd:PTZ00420 142 CSSGFDSFVNIWDIENEKRAFQInmpkkLSS-LKW 175
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 125-261 7.10e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 40.04  E-value: 7.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090230 125 ILATGLNDGQIKIWEVQ-TGLLLLNLSGHQDVVRDLSFTPNGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCC 203
Cdd:COG0823   1 LAFTLSRDGNSDIYVVDlDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASP 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56090230 204 SISPDCSMLCSAAGEKSVF-LWSMRsytlirkLEGHQSSVVSCD-----FSPDSALLVTASYDT 261
Cdd:COG0823  81 SWSPDGKRLAFVSRSDGRFdIYVLD-------LDGGAPRRLTDGpgspsWSPDGRRIVFSSDRG 137
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 292-320 8.73e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 8.73e-04
                           10        20
                   ....*....|....*....|....*....
gi 56090230    292 HMSSLRSVCFSPEGLYLATVADDRLLRIW 320
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
 368-400 1.17e-03

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 36.36  E-value: 1.17e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 56090230 368 SLKHLCRKALRRflTTYQVLALPIPKKMKDFLT 400
Cdd:cd03736   5 SLQHLCRITINK--CTRQIQELPLPTRLKDYLT 35
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
 368-401 1.53e-03

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 36.23  E-value: 1.53e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 56090230 368 SLKHLCRKALRRFLTTYQVLALPIPKKMKDFLTY 401
Cdd:cd03741   5 SLQHLCRFVIRKLVRRDHIPALPLPRRLIDYLRE 38
SOCS_CIS1 cd03734
SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like ...
 368-399 3.64e-03

SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. CIS1, like SOCS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. CIS1 binds to cytokine receptors at STAT5-docking sites, which prohibits recruitment of STAT5 to the receptor signaling complex and results in the down-regulation of activation by STAT5.


Pssm-ID: 239703  Cd Length: 41  Bit Score: 34.94  E-value: 3.64e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 56090230 368 SLKHLCRKALRRFLTtyQVLALPIPKKMKDFL 399
Cdd:cd03734   5 SLQHLCRLVINRLVT--DVDCLPLPRRMADYL 34
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 238-289 3.79e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.28  E-value: 3.79e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 56090230   238 HQSSVVSC-DFSPDSALLVTASYDTSVIMWDPYTGERL-RSLHHTQLEAPVDDS 289
Cdd:pfam20426 122 QHKDVVSCvAVTSDGSILATGSYDTTVMVWEVLRGRSSeKRSRNTQTEFPRKDH 175
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 368-399 4.93e-03

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 34.70  E-value: 4.93e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 56090230 368 SLKHLCRKALRRFLTTYQVLALPIPKKMKDFL 399
Cdd:cd03740   5 SLQYLCRFVIRQYTRIDLIQKLPLPNKMKGYL 36
WD40 pfam00400
WD domain, G-beta repeat;
292-320 5.27e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 5.27e-03
                          10        20
                  ....*....|....*....|....*....
gi 56090230   292 HMSSLRSVCFSPEGLYLATVADDRLLRIW 320
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 130-182 9.14e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 37.74  E-value: 9.14e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 56090230   130 LNDGQIkiweVQtgllllNLSGHQDVVRDLSFTPNGSlILVSASRDKTLRIWD 182
Cdd:pfam20426 111 LNDGRM----VQ------SIRQHKDVVSCVAVTSDGS-ILATGSYDTTVMVWE 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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