NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|57528225|ref|NP_001009640|]
View 

U3 small nucleolar RNA-associated protein 4 homolog [Rattus norvegicus]

Protein Classification

WD40 and YncE domain-containing protein( domain architecture ID 11455443)

WD40 and YncE domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-306 7.18e-35

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 7.18e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225   7 HRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLsANYFQEKFFPGHESRGTeALCW-AEGQRLFSAGLNGEILE 85
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVT-SVAFsPDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225  86 YDLQALNIKYTLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFEVTPDKIQfaRNFDRQKSRILSLSWHPAGTHVAAGSI 165
Cdd:COG2319 189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSA 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 166 D-YISVFDVKSGSITRKMvldRQHLGVtksrciVWGVAFLSDG-TVISVDSVGKVQLWDSATGTLVKSHLIANADVQSIA 243
Cdd:COG2319 267 DgTVRLWDLATGELLRTL---TGHSGG------VNSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 337

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 57528225 244 VADQEDSFVVGTAEGTVfhfQLVSVTSNSsekqwvRTKPFQHHTHDVRTVAHSP--TALISGGTD 306
Cdd:COG2319 338 FSPDGKTLASGSDDGTV---RLWDLATGE------LLRTLTGHTGAVTSVAFSPdgRTLASGSAD 393
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
442-547 5.22e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.37  E-value: 5.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 442 HILFSEDSTKLFVA-SNQGSLHVIHLSEGSFkhLHTFQPQSGTVEamclLAVSPDGNWLAASGTSAG-----VHIYDLHH 515
Cdd:COG3391 114 GLAVDPDGGRLYVAdSGNGRVSVIDTATGKV--VATIPVGAGPHG----IAVDPDGKRLYVANSGSNtvsviVSVIDTAT 187

                        90       100       110
                ....*....|....*....|....*....|..
gi 57528225 516 LKLHCTVPAYNFPVtALAIAPNTNNLVIAHSD 547
Cdd:COG3391 188 GKVVATIPVGGGPV-GVAVSPDGRRLYVANRG 218
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-306 7.18e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 7.18e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225   7 HRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLsANYFQEKFFPGHESRGTeALCW-AEGQRLFSAGLNGEILE 85
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVT-SVAFsPDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225  86 YDLQALNIKYTLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFEVTPDKIQfaRNFDRQKSRILSLSWHPAGTHVAAGSI 165
Cdd:COG2319 189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSA 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 166 D-YISVFDVKSGSITRKMvldRQHLGVtksrciVWGVAFLSDG-TVISVDSVGKVQLWDSATGTLVKSHLIANADVQSIA 243
Cdd:COG2319 267 DgTVRLWDLATGELLRTL---TGHSGG------VNSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 337

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 57528225 244 VADQEDSFVVGTAEGTVfhfQLVSVTSNSsekqwvRTKPFQHHTHDVRTVAHSP--TALISGGTD 306
Cdd:COG2319 338 FSPDGKTLASGSDDGTV---RLWDLATGE------LLRTLTGHTGAVTSVAFSPdgRTLASGSAD 393
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-306 1.75e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.37  E-value: 1.75e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225  16 PSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANyFQEKFFPGHESRGTEALCWAEGQRLFSAGLNGEILEYDLQALNIKY 95
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225  96 TLDAFGGPIWSMTASPSGsQLLVGC-EDGSVKLFEVTPDKIQFArnFDRQKSRILSLSWHPAGTHVAAGSID-YISVFDV 173
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDG-RILSSSsRDKTIKVWDVETGKCLTT--LRGHTDWVNSVAFSPDGTFVASSSQDgTIKLWDL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 174 KSGSitrkmvLDRQHLGVTKSrciVWGVAFLSDG-TVISVDSVGKVQLWDSATGTLVKSHLIANADVQSIAVADQEDSFV 252
Cdd:cd00200 165 RTGK------CVATLTGHTGE---VNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 57528225 253 VGTAEGTVFHFQLVSvtsnssekqWVRTKPFQHHTHDVRTVAHSPTA--LISGGTD 306
Cdd:cd00200 236 SGSEDGTIRVWDLRT---------GECVQTLSGHTNSVTSLAWSPDGkrLASGSAD 282
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
442-547 5.22e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.37  E-value: 5.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 442 HILFSEDSTKLFVA-SNQGSLHVIHLSEGSFkhLHTFQPQSGTVEamclLAVSPDGNWLAASGTSAG-----VHIYDLHH 515
Cdd:COG3391 114 GLAVDPDGGRLYVAdSGNGRVSVIDTATGKV--VATIPVGAGPHG----IAVDPDGKRLYVANSGSNtvsviVSVIDTAT 187

                        90       100       110
                ....*....|....*....|....*....|..
gi 57528225 516 LKLHCTVPAYNFPVtALAIAPNTNNLVIAHSD 547
Cdd:COG3391 188 GKVVATIPVGGGPV-GVAVSPDGRRLYVANRG 218
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 445-590 6.53e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 6.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 445 FSEDSTKLFVASNQGSLHVIHLSEGSFkhLHTFQPQSGTVEAmclLAVSPDGNWLAASGTSAGVHIYDLHHLKLHCTVPA 524
Cdd:cd00200  17 FSPDGKLLATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRD---VAASADGTYLASGSSDKTIRLWDLETGECVRTLTG 91

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 57528225 525 YNFPVTALAIAPNTNNLVIAHSDQQVFEFSIPDKQYtewsrsVQKQGFHQLWlqrdtpITHISIHP 590
Cdd:cd00200  92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC------LTTLRGHTDW------VNSVAFSP 145
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 107-202 8.32e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.80  E-value: 8.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225   107 MTASPSGSQLLVGCEDGSVKLFEVTPDKIqFARNFDRQKSRILSLSWHPAGTHVAAGSID-YISVFDVKSGSITRKmvLD 185
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRV-WTLSPDKEDLEVTSLAWRPDGKLLAVGYSDgTVRLLDAENGKIVHH--FS 77

                          90
                  ....*....|....*..
gi 57528225   186 RQHLGVTksrCIVWGVA 202
Cdd:pfam12894  78 AGSDLIT---CLGWGEN 91
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 92-129 1.12e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.12e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 57528225     92 NIKYTLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFE 129
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-306 7.18e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 7.18e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225   7 HRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLsANYFQEKFFPGHESRGTeALCW-AEGQRLFSAGLNGEILE 85
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVT-SVAFsPDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225  86 YDLQALNIKYTLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFEVTPDKIQfaRNFDRQKSRILSLSWHPAGTHVAAGSI 165
Cdd:COG2319 189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSA 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 166 D-YISVFDVKSGSITRKMvldRQHLGVtksrciVWGVAFLSDG-TVISVDSVGKVQLWDSATGTLVKSHLIANADVQSIA 243
Cdd:COG2319 267 DgTVRLWDLATGELLRTL---TGHSGG------VNSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 337

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 57528225 244 VADQEDSFVVGTAEGTVfhfQLVSVTSNSsekqwvRTKPFQHHTHDVRTVAHSP--TALISGGTD 306
Cdd:COG2319 338 FSPDGKTLASGSDDGTV---RLWDLATGE------LLRTLTGHTGAVTSVAFSPdgRTLASGSAD 393
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-306 1.75e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.37  E-value: 1.75e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225  16 PSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANyFQEKFFPGHESRGTEALCWAEGQRLFSAGLNGEILEYDLQALNIKY 95
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225  96 TLDAFGGPIWSMTASPSGsQLLVGC-EDGSVKLFEVTPDKIQFArnFDRQKSRILSLSWHPAGTHVAAGSID-YISVFDV 173
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDG-RILSSSsRDKTIKVWDVETGKCLTT--LRGHTDWVNSVAFSPDGTFVASSSQDgTIKLWDL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 174 KSGSitrkmvLDRQHLGVTKSrciVWGVAFLSDG-TVISVDSVGKVQLWDSATGTLVKSHLIANADVQSIAVADQEDSFV 252
Cdd:cd00200 165 RTGK------CVATLTGHTGE---VNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 57528225 253 VGTAEGTVFHFQLVSvtsnssekqWVRTKPFQHHTHDVRTVAHSPTA--LISGGTD 306
Cdd:cd00200 236 SGSEDGTIRVWDLRT---------GECVQTLSGHTNSVTSLAWSPDGkrLASGSAD 282
WD40 COG2319
WD40 repeat [General function prediction only];
17-260 5.36e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.79  E-value: 5.36e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225  17 SGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYfQEKFFPGHESRGTeALCWA-EGQRLFSAGLNGEILEYDLQALNIKY 95
Cdd:COG2319 163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVR-SVAFSpDGKLLASGSADGTVRLWDLATGKLLR 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225  96 TLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFEVTPDKIQfaRNFDRQKSRILSLSWHPAGTHVAAGSIDY-ISVFDVK 174
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLA 318

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 175 SGSITrkmvldRQHLGVTKSrciVWGVAFLSDG-TVISVDSVGKVQLWDSATGTLVKSHLIANADVQSIAVADQEDSFVV 253
Cdd:COG2319 319 TGKLL------RTLTGHTGA---VRSVAFSPDGkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389


                ....*..
gi 57528225 254 GTAEGTV 260
Cdd:COG2319 390 GSADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
55-550 2.87e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.70  E-value: 2.87e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225  55 FPGHESRGTEALCWAEGQRLFSAGLNGEILEYDLQALNIKYTLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFEVTPDK 134
Cdd:COG2319  32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 135 IqfARNFDRQKSRILSLSWHPAGTHVAAGSIDY-ISVFDVKSGSITRkmVLDRQHLGVtksrcivWGVAFLSDG-TVISV 212
Cdd:COG2319 112 L--LRTLTGHTGAVRSVAFSPDGKTLASGSADGtVRLWDLATGKLLR--TLTGHSGAV-------TSVAFSPDGkLLASG 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 213 DSVGKVQLWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTAEGTVfhfQLVSVTSNssekQWVRTkpFQHHTHDVRT 292
Cdd:COG2319 181 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV---RLWDLATG----KLLRT--LTGHSGSVRS 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 293 VAHSP--TALISGGTDthlvirplmekvevknydaalrkitfphrrliscskrrqlllfqfaHHLELWRLgstaATGKNG 370
Cdd:COG2319 252 VAFSPdgRLLASGSAD----------------------------------------------GTVRLWDL----ATGELL 281

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 371 DTLplsknadhllhlktKGPENIICSCVspcgswiaystasrfflyrlkyerdnislqrvsklpaflrsalhilFSEDST 450
Cdd:COG2319 282 RTL--------------TGHSGGVNSVA----------------------------------------------FSPDGK 301

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 451 KLFVASNQGSLHVIHLSEGsfKHLHTFQPQSGTVEAmclLAVSPDGNWLAASGTSAGVHIYDLHHLKLHCTVPAYNFPVT 530
Cdd:COG2319 302 LLASGSDDGTVRLWDLATG--KLLRTLTGHTGAVRS---VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT 376

                       490       500
                ....*....|....*....|
gi 57528225 531 ALAIAPNTNNLVIAHSDQQV 550
Cdd:COG2319 377 SVAFSPDGRTLASGSADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
16-513 2.50e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.01  E-value: 2.50e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225  16 PSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYfQEKFFPGHESRGTEALCWAEGQRLFSAGLNGEILEYDLQALNIKY 95
Cdd:COG2319  36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGA-LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225  96 TLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFEVTPDKiqFARNFDRQKSRILSLSWHPAGTHVAAGSIDY-ISVFDVK 174
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGtVRLWDLA 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 175 SGSITRKMvldRQHLGVtksrciVWGVAFLSDG-TVISVDSVGKVQLWDSATGTLVKSHLIANADVQSIAVADQEDSFVV 253
Cdd:COG2319 193 TGKLLRTL---TGHTGA------VRSVAFSPDGkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 254 GTAEGTVfhfQLVSVTSnsseKQWVRTkpFQHHTHDVRTVAHSP--TALISGGTDthlvirplmekvevknydaalrkit 331
Cdd:COG2319 264 GSADGTV---RLWDLAT----GELLRT--LTGHSGGVNSVAFSPdgKLLASGSDD------------------------- 309

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 332 fphrrliscskrrqlllfqfaHHLELWRLgstaATGKNGDTLplsknadhllhlktKGPENIICSCVspcgswiaystas 411
Cdd:COG2319 310 ---------------------GTVRLWDL----ATGKLLRTL--------------TGHTGAVRSVA------------- 337

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 412 rfflyrlkyerdnislqrvsklpaflrsalhilFSEDSTKLFVASNQGSLHVIHLSEGsfKHLHTFQPQSGTVEAmclLA 491
Cdd:COG2319 338 ---------------------------------FSPDGKTLASGSDDGTVRLWDLATG--ELLRTLTGHTGAVTS---VA 379

                       490       500
                ....*....|....*....|..
gi 57528225 492 VSPDGNWLAASGTSAGVHIYDL 513
Cdd:COG2319 380 FSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
109-550 1.67e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.29  E-value: 1.67e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 109 ASPSGSQLLVGCEDGSVKLFEVTPDkiQFARNFDRQKSRILSLSWHPAGTHVAAGSIDYISVFDVKSGSITRKMVLDRQH 188
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALG--ALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 189 LgvtksrciVWGVAFLSDGTVI-SVDSVGKVQLWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTAEGTVfhfQLVS 267
Cdd:COG2319  80 A--------VLSVAFSPDGRLLaSASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV---RLWD 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 268 VTSnsseKQWVRTkpFQHHTHDVRTVAHSP--TALISGGTDthlvirplmekvevknydaalrkitfphrrliscskrrq 345
Cdd:COG2319 149 LAT----GKLLRT--LTGHSGAVTSVAFSPdgKLLASGSDD--------------------------------------- 183

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 346 lllfqfaHHLELWRLgstaATGKNGDTLplsknadhllhlktKGPENIICS-CVSPCGSWIAYSTASRF-FLYRLKyerd 423
Cdd:COG2319 184 -------GTVRLWDL----ATGKLLRTL--------------TGHTGAVRSvAFSPDGKLLASGSADGTvRLWDLA---- 234

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 424 niSLQRVSKLPAFLRSALHILFSEDSTKLFVASNQGSLHVIHLSEGsfKHLHTFQPQSGTVEAmclLAVSPDGNWLAASG 503
Cdd:COG2319 235 --TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG--ELLRTLTGHSGGVNS---VAFSPDGKLLASGS 307

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*..
gi 57528225 504 TSAGVHIYDLHHLKLHCTVPAYNFPVTALAIAPNTNNLVIAHSDQQV 550
Cdd:COG2319 308 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-411 8.26e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.53  E-value: 8.26e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225  96 TLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFEVTPDKIQFarnfdRQKSRILSL---SWHPAGTHVAAGSIDY-ISVF 171
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-----TLKGHTGPVrdvAASADGTYLASGSSDKtIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 172 DVKSGSITRKMVldrqhlGVTKSrciVWGVAFLSDGTVISVDSV-GKVQLWDSATGTLVKSHLIANADVQSIAVaDQEDS 250
Cdd:cd00200  79 DLETGECVRTLT------GHTSY---VSSVAFSPDGRILSSSSRdKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGT 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 251 FVV-GTAEGTVFhfqLVSVTSNSSEKQwvrtkpFQHHTHDVRTVAHSPTA--LISGGTDTHLVIRPLMEKVEVKNYDAAL 327
Cdd:cd00200 149 FVAsSSQDGTIK---LWDLRTGKCVAT------LTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHE 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 328 RKITF----PHRRLISCSKRRQlllfqfahHLELWRLgstaATGKNGDTLPLSKNAdhllhlktkgpenIICSCVSPCGS 403
Cdd:cd00200 220 NGVNSvafsPDGYLLASGSEDG--------TIRVWDL----RTGECVQTLSGHTNS-------------VTSLAWSPDGK 274


                ....*...
gi 57528225 404 WIAysTAS 411
Cdd:cd00200 275 RLA--SGS 280
WD40 COG2319
WD40 repeat [General function prediction only];
8-131 3.47e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.78  E-value: 3.47e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225   8 RVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLsANYFQEKFFPGHESRGTeALCW-AEGQRLFSAGLNGEILEY 86
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVR-SVAFsPDGKTLASGSDDGTVRLW 357

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 57528225  87 DLQALNIKYTLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFEVT 131
Cdd:COG2319 358 DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-129 1.72e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.35  E-value: 1.72e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225  17 SGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANyFQEKFFPGHESRGTeALCWAEGQRLF-SAGLNGEILEYDLQALNIKY 95
Cdd:cd00200 178 GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVN-SVAFSPDGYLLaSGSEDGTIRVWDLRTGECVQ 255

                        90       100       110
                ....*....|....*....|....*....|....
gi 57528225  96 TLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFE 129
Cdd:cd00200 256 TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
442-547 5.22e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.37  E-value: 5.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 442 HILFSEDSTKLFVA-SNQGSLHVIHLSEGSFkhLHTFQPQSGTVEamclLAVSPDGNWLAASGTSAG-----VHIYDLHH 515
Cdd:COG3391 114 GLAVDPDGGRLYVAdSGNGRVSVIDTATGKV--VATIPVGAGPHG----IAVDPDGKRLYVANSGSNtvsviVSVIDTAT 187

                        90       100       110
                ....*....|....*....|....*....|..
gi 57528225 516 LKLHCTVPAYNFPVtALAIAPNTNNLVIAHSD 547
Cdd:COG3391 188 GKVVATIPVGGGPV-GVAVSPDGRRLYVANRG 218
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 445-590 6.53e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 6.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 445 FSEDSTKLFVASNQGSLHVIHLSEGSFkhLHTFQPQSGTVEAmclLAVSPDGNWLAASGTSAGVHIYDLHHLKLHCTVPA 524
Cdd:cd00200  17 FSPDGKLLATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRD---VAASADGTYLASGSSDKTIRLWDLETGECVRTLTG 91

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 57528225 525 YNFPVTALAIAPNTNNLVIAHSDQQVFEFSIPDKQYtewsrsVQKQGFHQLWlqrdtpITHISIHP 590
Cdd:cd00200  92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC------LTTLRGHTDW------VNSVAFSP 145
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 107-202 8.32e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.80  E-value: 8.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225   107 MTASPSGSQLLVGCEDGSVKLFEVTPDKIqFARNFDRQKSRILSLSWHPAGTHVAAGSID-YISVFDVKSGSITRKmvLD 185
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRV-WTLSPDKEDLEVTSLAWRPDGKLLAVGYSDgTVRLLDAENGKIVHH--FS 77

                          90
                  ....*....|....*..
gi 57528225   186 RQHLGVTksrCIVWGVA 202
Cdd:pfam12894  78 AGSDLIT---CLGWGEN 91
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 92-129 1.12e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.12e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 57528225     92 NIKYTLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFE 129
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
10-226 2.58e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.06  E-value: 2.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225  10 RFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRGTEALCWAEGQRLF-SAGLNGEILEYDL 88
Cdd:COG3391  18 LAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYvANSGSGRVSVIDL 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225  89 QALNIKYTLDAFGGPiWSMTASPSGSQLLVGCEDGSvKLFEVTPDKIQFARNFDRQKSrILSLSWHPAGTHVAAGSID-- 166
Cdd:COG3391  98 ATGKVVATIPVGGGP-RGLAVDPDGGRLYVADSGNG-RVSVIDTATGKVVATIPVGAG-PHGIAVDPDGKRLYVANSGsn 174

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 57528225 167 ----YISVFDVKSGSITRKMVLDRQhlgvtksrciVWGVAFLSDGTVI---------SVDSVGKVQLWDSATG 226
Cdd:COG3391 175 tvsvIVSVIDTATGKVVATIPVGGG----------PVGVAVSPDGRRLyvanrgsntSNGGSNTVSVIDLATL 237
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 387-511 3.37e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 38.88  E-value: 3.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 387 TKGPENIICSCVSPCGSWIAYST--ASRFFLYRlkYERDNISLQRVSKLPAFLRSALhilFSEDSTKLFVASNQGS---L 461
Cdd:COG0823  27 TNSPGIDTSPAWSPDGRRIAFTSdrGGGPQIYV--VDADGGEPRRLTFGGGYNASPS---WSPDGKRLAFVSRSDGrfdI 101

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 57528225 462 HVIHLSEGSFKHLhTFQPQSGtveamcllAVSPDGNWLA-ASGTSAGVHIY 511
Cdd:COG0823 102 YVLDLDGGAPRRL-TDGPGSP--------SWSPDGRRIVfSSDRGGRPDLY 143
Frtz pfam11768
WD repeat-containing and planar cell polarity effector protein Fritz; Fritz is a probable ...
 103-173 6.84e-03

WD repeat-containing and planar cell polarity effector protein Fritz; Fritz is a probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. In Drosophila melanogaster, fritz regulates both the location and the number of wing cell prehair initiation sites.


Pssm-ID: 432059  Cd Length: 544  Bit Score: 39.49  E-value: 6.84e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 57528225   103 PIWSMTASPSGSQLLVGCEDGSVKLFEVTPDKIQFArnfdrqKSRILS--LSWHPAGTHVAAGSID-YISVFDV 173
Cdd:pfam11768 261 PVISCARNHAEDKLLLGCEDSSLILYEGHRKITLLA------QAAVTPhlIRWHPAGAIILVCSAQgELQIFDM 328
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 490-559 7.52e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 38.86  E-value: 7.52e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528225 490 LAVSPDGNWLAASGTSAGVHIYDLHHLKLHCTVPAYNFPVTALAIAPNTNNLVIAHSDQQVFEFSIPDKQ 559
Cdd:cd00200  15 VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH