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Conserved domains on  [gi|58865544|ref|NP_001011984|]
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ankyrin repeat and SOCS box protein 2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
119-400 6.45e-46

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 164.36  E-value: 6.45e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 119 EALKAMIQDGKNLAEPNKEGWLPLHEAAYYGKLGCLKVLQRAYPGTIDQRTLQEETALYLATCREHLDCLLSLLQAGAEP 198
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 199 DISNKSRETPLYKACERKNAEAVRILVQYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLFVA 278
Cdd:COG0666  81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 279 AQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLLP 358
Cdd:COG0666 161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 58865544 359 VTSR-TRVRRSGISPLHLAAERNHDAVLEALLAARFDVNTPLA 400
Cdd:COG0666 241 AGADlNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 590-634 1.50e-23

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239691  Cd Length: 45  Bit Score: 93.39  E-value: 1.50e-23
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 58865544 590 EPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ 634
Cdd:cd03721   1 EPPRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQETQ 45
Ank_2 pfam12796
Ankyrin repeats (3 copies);
373-469 5.22e-10

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.28  E-value: 5.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544   373 LHLAAERNHDAVLEALLAARFDVNtplaperarLYEDRRTSALYFAVVNNNVYATELLLlAGADPNRDVI--SPLLVAIR 450
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADAN---------LQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKDNgrTALHYAAR 70

                          90
                  ....*....|....*....
gi 58865544   451 HGCLRTMQLLLDHGANIDA 469
Cdd:pfam12796  71 SGHLEIVKLLLEKGADINV 89
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
119-400 6.45e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 164.36  E-value: 6.45e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 119 EALKAMIQDGKNLAEPNKEGWLPLHEAAYYGKLGCLKVLQRAYPGTIDQRTLQEETALYLATCREHLDCLLSLLQAGAEP 198
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 199 DISNKSRETPLYKACERKNAEAVRILVQYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLFVA 278
Cdd:COG0666  81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 279 AQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLLP 358
Cdd:COG0666 161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 58865544 359 VTSR-TRVRRSGISPLHLAAERNHDAVLEALLAARFDVNTPLA 400
Cdd:COG0666 241 AGADlNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 590-634 1.50e-23

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 93.39  E-value: 1.50e-23
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 58865544 590 EPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ 634
Cdd:cd03721   1 EPPRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQETQ 45
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 150-469 2.00e-23

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 105.15  E-value: 2.00e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  150 KLG--CLKVLQRAYPGTIDQRTLQEETALYLATCREHL--DCLL---SLLQAGAEPDISNKSRETPLYKACERKNAEAVR 222
Cdd:PHA02876 116 KLDeaCIHILKEAISGNDIHYDKINESIEYMKLIKERIqqDELLiaeMLLEGGADVNAKDIYCITPIHYAAERGNAKMVN 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  223 ILVQYNADAN-----------------------------HRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNVYSIT 273
Cdd:PHA02876 196 LLLSYGADVNiialddlsvlecavdsknidtikaiidnrSNINKNDLSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNT 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  274 PLFVAAQSGQLEAL-RFLAKHGADINTQASDSASALYEACKNEHE-DVVEFLLSQGADANKANKDGLLPLHVASKKGNYR 351
Cdd:PHA02876 276 PLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYDtENIRTLIMLGADVNAADRLYITPLHQASTLDRNK 355

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  352 -IVQMLLPVTSRTRVRR-SGISPLHLAAERNHDAVLEALLAARFDVNTplaperarlYEDRRTSALYFAVVNNNVY-ATE 428
Cdd:PHA02876 356 dIVITLLELGANVNARDyCDKTPIHYAAVRNNVVIINTLLDYGADIEA---------LSQKIGTALHFALCGTNPYmSVK 426

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 58865544  429 LLLLAGAD---PNRDVISPLLVAIRHGC-LRTMQLLLDHGANIDA 469
Cdd:PHA02876 427 TLIDRGANvnsKNKDLSTPLHYACKKNCkLDVIEMLLDNGADVNA 471
Ank_2 pfam12796
Ankyrin repeats (3 copies);
176-268 3.08e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 79.77  E-value: 3.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544   176 LYLATCREHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVQYnADANHRCNrGWTALHESVSRNDLEVME 255
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 58865544   256 ILVSGGAKVEAKN 268
Cdd:pfam12796  79 LLLEKGADINVKD 91
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 591-629 3.32e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 58.33  E-value: 3.32e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 58865544   591 PPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLK 629
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
373-469 5.22e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.28  E-value: 5.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544   373 LHLAAERNHDAVLEALLAARFDVNtplaperarLYEDRRTSALYFAVVNNNVYATELLLlAGADPNRDVI--SPLLVAIR 450
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADAN---------LQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKDNgrTALHYAAR 70

                          90
                  ....*....|....*....
gi 58865544   451 HGCLRTMQLLLDHGANIDA 469
Cdd:pfam12796  71 SGHLEIVKLLLEKGADINV 89
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 140-357 1.43e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 60.80  E-value: 1.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 140 LPLHEAAYYGKLGCLKVLQRAYPGTIDQRTLQEETALYLATCREHLDCLLSLLQAGaePDISNKSRETPLYKacerknae 219
Cdd:cd22192  19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAA--PELVNEPMTSDLYQ-------- 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 220 avrilvqynadanhrcnrGWTALHESVSRNDLEVMEILVSGGAKV------------EAKNV--YSITPLFVAAQSGQLE 285
Cdd:cd22192  89 ------------------GETALHIAVVNQNLNLVRELIARGADVvspratgtffrpGPKNLiyYGEHPLSFAACVGNEE 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 286 ALRFLAKHGADINTQASDSASALY----EACKNEHEDVVEFLLSQGADANKA------NKDGLLPLHVASKKGNYRIVQM 355
Cdd:cd22192 151 IVRLLIEHGADIRAQDSLGNTVLHilvlQPNKTFACQMYDLILSYDKEDDLQpldlvpNNQGLTPFKLAAKEGNIVMFQH 230


                ..
gi 58865544 356 LL 357
Cdd:cd22192 231 LV 232
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 593-631 3.41e-08

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 49.71  E-value: 3.41e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 58865544    593 RPLAHLCRLRVRKAIGKyriklLDTLPLPGRLIRYLKYE 631
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 237-357 5.61e-07

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 52.78  E-value: 5.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544   237 RGWTALHESVSRNDLEVMEILVSGGAKVEAKNV--------------YSITPLFVAAQSGQLEALRFLAKHGADINTQAS 302
Cdd:TIGR00870 127 PGITALHLAAHRQNYEIVKLLLERGASVPARACgdffvksqgvdsfyHGESPLNAAACLGSPSIVALLSEDPADILTADS 206

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58865544   303 DS-----ASALYEACKNEHEDVV----EFLLSQGADANKA-------NKDGLLPLHVASKKGNYRIVQMLL 357
Cdd:TIGR00870 207 LGntllhLLVMENEFKAEYEELScqmyNFALSLLDKLRDSkelevilNHQGLTPLKLAAKEGRIVLFRLKL 277
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 339-486 7.47e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.86  E-value: 7.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 339 LPLHVASKKGNYRIVQMLLpVTSRTRVRRSGI---SPLHLAAERNHDAVLEALL-AARFDVNTPLAPErarLYEDRrtSA 414
Cdd:cd22192  19 SPLLLAAKENDVQAIKKLL-KCPSCDLFQRGAlgeTALHVAALYDNLEAAVVLMeAAPELVNEPMTSD---LYQGE--TA 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 415 LYFAVVNNNVYATELLLLAGAD------------PNRDVI-----SPLLVAIRHGCLRTMQLLLDHGANIDA-------- 469
Cdd:cd22192  93 LHIAVVNQNLNLVRELIARGADvvspratgtffrPGPKNLiyygeHPLSFAACVGNEEIVRLLIEHGADIRAqdslgntv 172

                       170
                ....*....|....*....
gi 58865544 470 --YIATHPTAFPATIMFAM 486
Cdd:cd22192 173 lhILVLQPNKTFACQMYDL 191
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 406-503 1.40e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 47.29  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  406 LYEDRRTSALYFAVVNNNVYATELLLLAGADPNR----DVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPAT 481
Cdd:PHA02884  65 LSENSKTNPLIYAIDCDNDDAAKLLIRYGADVNRyaeeAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELA 144

                         90       100
                 ....*....|....*....|..
gi 58865544  482 IMFamkCLSLLKFLMdlgCDGE 503
Cdd:PHA02884 145 LMI---CNNFLAFMI---CDNE 160
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 273-298 1.71e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 1.71e-03
                           10        20
                   ....*....|....*....|....*.
gi 58865544    273 TPLFVAAQSGQLEALRFLAKHGADIN 298
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
119-400 6.45e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 164.36  E-value: 6.45e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 119 EALKAMIQDGKNLAEPNKEGWLPLHEAAYYGKLGCLKVLQRAYPGTIDQRTLQEETALYLATCREHLDCLLSLLQAGAEP 198
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 199 DISNKSRETPLYKACERKNAEAVRILVQYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLFVA 278
Cdd:COG0666  81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 279 AQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLLP 358
Cdd:COG0666 161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 58865544 359 VTSR-TRVRRSGISPLHLAAERNHDAVLEALLAARFDVNTPLA 400
Cdd:COG0666 241 AGADlNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
110-357 2.82e-44

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 159.73  E-value: 2.82e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 110 LKAIKEGDEEALKAMIQDGKNLAEPNKEGWLPLHEAAYYGKLGCLKVLQRAYPGTIDQRTLQEETALYLATCREHLDCLL 189
Cdd:COG0666  25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVK 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 190 SLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVQYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNV 269
Cdd:COG0666 105 LLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDN 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 270 YSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGN 349
Cdd:COG0666 185 DGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGA 264


                ....*...
gi 58865544 350 YRIVQMLL 357
Cdd:COG0666 265 ALIVKLLL 272
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
165-438 1.25e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 152.80  E-value: 1.25e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 165 IDQRTLQEETALYLATCREHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVQYNADANHRCNRGWTALHE 244
Cdd:COG0666  14 ALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 245 SVSRNDLEVMEILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLL 324
Cdd:COG0666  94 AARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 325 SQGADANKANKDGLLPLHVASKKGNYRIVQMLL----PVTSRTRvrrSGISPLHLAAERNHDAVLEALLAARFDVNTPLa 400
Cdd:COG0666 174 EAGADVNARDNDGETPLHLAAENGHLEIVKLLLeagaDVNAKDN---DGKTALDLAAENGNLEIVKLLLEAGADLNAKD- 249

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 58865544 401 perarlyeDRRTSALYFAVVNNNVYATELLLLAGADPN 438
Cdd:COG0666 250 --------KDGLTALLLAAAAGAALIVKLLLLALLLLA 279
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
110-341 6.56e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 147.79  E-value: 6.56e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 110 LKAIKEGDEEALKAMIQDGKNLAEPNKEGWLPLHEAAYYGKLGCLKVLQRAyPGTIDQRTLQEETALYLATCREHLDCLL 189
Cdd:COG0666  59 LAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEA-GADVNARDKDGETPLHLAAYNGNLEIVK 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 190 SLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVQYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNV 269
Cdd:COG0666 138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN 217

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 58865544 270 YSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLSQGADANKANKDGLLPL 341
Cdd:COG0666 218 DGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
188-477 1.09e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 136.24  E-value: 1.09e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 188 LLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVQYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAK 267
Cdd:COG0666   4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 268 NVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLSQGADANKANKDGllplhvaskk 347
Cdd:COG0666  84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDG---------- 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 348 gnyrivqmllpvtsrtrvrrsgISPLHLAAERNHDAVLEALLAARFDVNTPlaperarlyEDRRTSALYFAVVNNNVYAT 427
Cdd:COG0666 154 ----------------------NTPLHLAAANGNLEIVKLLLEAGADVNAR---------DNDGETPLHLAAENGHLEIV 202

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 58865544 428 ELLLLAGADPN---RDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTA 477
Cdd:COG0666 203 KLLLEAGADVNakdNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 590-634 1.50e-23

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 93.39  E-value: 1.50e-23
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 58865544 590 EPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ 634
Cdd:cd03721   1 EPPRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQETQ 45
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 150-469 2.00e-23

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 105.15  E-value: 2.00e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  150 KLG--CLKVLQRAYPGTIDQRTLQEETALYLATCREHL--DCLL---SLLQAGAEPDISNKSRETPLYKACERKNAEAVR 222
Cdd:PHA02876 116 KLDeaCIHILKEAISGNDIHYDKINESIEYMKLIKERIqqDELLiaeMLLEGGADVNAKDIYCITPIHYAAERGNAKMVN 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  223 ILVQYNADAN-----------------------------HRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNVYSIT 273
Cdd:PHA02876 196 LLLSYGADVNiialddlsvlecavdsknidtikaiidnrSNINKNDLSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNT 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  274 PLFVAAQSGQLEAL-RFLAKHGADINTQASDSASALYEACKNEHE-DVVEFLLSQGADANKANKDGLLPLHVASKKGNYR 351
Cdd:PHA02876 276 PLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYDtENIRTLIMLGADVNAADRLYITPLHQASTLDRNK 355

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  352 -IVQMLLPVTSRTRVRR-SGISPLHLAAERNHDAVLEALLAARFDVNTplaperarlYEDRRTSALYFAVVNNNVY-ATE 428
Cdd:PHA02876 356 dIVITLLELGANVNARDyCDKTPIHYAAVRNNVVIINTLLDYGADIEA---------LSQKIGTALHFALCGTNPYmSVK 426

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 58865544  429 LLLLAGAD---PNRDVISPLLVAIRHGC-LRTMQLLLDHGANIDA 469
Cdd:PHA02876 427 TLIDRGANvnsKNKDLSTPLHYACKKNCkLDVIEMLLDNGADVNA 471
PHA03095 PHA03095
ankyrin-like protein; Provisional
 199-480 2.42e-23

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 103.57  E-value: 2.42e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  199 DISNKSRETPLYK---ACERKNAEAVRILVQYNADANHRCNRGWTALHESVSRN---DLEVMEILVSGGAKVEAKNVYSI 272
Cdd:PHA03095   5 ESVDIIMEAALYDyllNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSsekVKDIVRLLLEAGADVNAPERCGF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  273 TPLFVAAQSGQ-LEALRFLAKHGADINTQ--ASDSASALYEACKNEHEDVVEFLLSQGADANKANKDGLLPLHV--ASKK 347
Cdd:PHA03095  85 TPLHLYLYNATtLDVIKLLIKAGADVNAKdkVGRTPLHVYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVllKSRN 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  348 GNYRIVQMLLPVTSRTRVRRS-GISPLHLAAE--RNHDAVLEALLAARFDV-------NTPL------APERARL----- 406
Cdd:PHA03095 165 ANVELLRLLIDAGADVYAVDDrFRSLLHHHLQsfKPRARIVRELIRAGCDPaatdmlgNTPLhsmatgSSCKRSLvlpll 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  407 -------YEDRR-TSALYFAVVNNNVYATELLLLAGADPN---RDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHP 475
Cdd:PHA03095 245 iagisinARNRYgQTPLHYAAVFNNPRACRRLIALGADINavsSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVAATLN 324


                 ....*
gi 58865544  476 TAFPA 480
Cdd:PHA03095 325 TASVA 329
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 176-357 2.47e-21

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 97.04  E-value: 2.47e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  176 LYLATCREHLDCLLSLLQAGAEPDISNKSRETPL-----YKACERKNAEAVRILVQYNADANHRCNRGWTALHESVSR-- 248
Cdd:PHA03100  39 LYLAKEARNIDVVKILLDNGADINSSTKNNSTPLhylsnIKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKks 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  249 NDLEVMEILVSGGAKVEAKNVYSITPLFVAAQSGQ--LEALRFLAKHGADINtqASDSA------------------SAL 308
Cdd:PHA03100 119 NSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDIN--AKNRVnyllsygvpinikdvygfTPL 196

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 58865544  309 YEACKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLL 357
Cdd:PHA03100 197 HYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
284-501 5.58e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.48  E-value: 5.58e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 284 LEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLL-PVTSR 362
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLaAGADI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 363 TRVRRSGISPLHLAAERNHDAVLEALLAARFDVNTPlaperarlyEDRRTSALYFAVVNNNVYATELLLLAGADPN---R 439
Cdd:COG0666  81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR---------DKDGETPLHLAAYNGNLEIVKLLLEAGADVNaqdN 151

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 58865544 440 DVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAfpatIMFAMKC--LSLLKFLMDLGCD 501
Cdd:COG0666 152 DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETP----LHLAAENghLEIVKLLLEAGAD 211
Ank_2 pfam12796
Ankyrin repeats (3 copies);
176-268 3.08e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 79.77  E-value: 3.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544   176 LYLATCREHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVQYnADANHRCNrGWTALHESVSRNDLEVME 255
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 58865544   256 ILVSGGAKVEAKN 268
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 198-473 4.33e-18

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 87.03  E-value: 4.33e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  198 PDISNKSRETPLYKACERKNAEAVRILVQYNADANHRCNRGWTALH-----ESVSRNDLEVMEILVSGGAKVEAKNVYSI 272
Cdd:PHA03100  28 NDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHylsniKYNLTDVKEIVKLLLEYGANVNAPDNNGI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  273 TPLFVAAQ--SGQLEALRFLAKHGADINTQASDSASALYEACKNEHED--VVEFLLSQGADANKANK-DGLL----PLHV 343
Cdd:PHA03100 108 TPLLYAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINAKNRvNYLLsygvPINI 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  344 ASKKGNyrivqmllpvtsrtrvrrsgiSPLHLAAERNHdavleallaarfdvntplaPErarlyedrrtsalyfaVVNnn 423
Cdd:PHA03100 188 KDVYGF---------------------TPLHYAVYNNN-------------------PE----------------FVK-- 209

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 58865544  424 vyateLLLLAGADPN-RDVI--SPLLVAIRHGCLRTMQLLLDHGANIDAYIAT 473
Cdd:PHA03100 210 -----YLLDLGANPNlVNKYgdTPLHIAILNNNKEIFKLLLNNGPSIKTIIET 257
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 92-390 1.51e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 85.40  E-value: 1.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544   92 KYSSNLFKTSQMAAMDPVLKAIKEGDEEALKAMIQDGKNLAEPNKEGWLPLHEAAyygKLGCLKVLQRAYPGTIDqrtlq 171
Cdd:PHA02874  22 KNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAI---KIGAHDIIKLLIDNGVD----- 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  172 eeTALYLATCREHlDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVQYNADANHRCNRGWTALHESVSRNDL 251
Cdd:PHA02874  94 --TSILPIPCIEK-DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFF 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  252 EVMEILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNeHEDVVEFLLSQgADAN 331
Cdd:PHA02874 171 DIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIH-NRSAIELLINN-ASIN 248

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 58865544  332 KANKDGLLPLHVA-SKKGNYRIVQMLLPVTSRTRVR-RSGISPLHLAAER-NHDAVLEALLA 390
Cdd:PHA02874 249 DQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKdNKGENPIDTAFKYiNKDPVIKDIIA 310
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 108-347 1.57e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 85.70  E-value: 1.57e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  108 PVLKAIKEGDEEALKAMIQDGKNLAEPNKEGWLPLH-------------------------------EAAYYGKLGCLK- 155
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHiickepnklgmkemirsinkcsvfytlvaikDAFNNRNVEIFKi 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  156 VLQRAYPGTIDQRTLQEETALYLATCREHLDCLLslLQAGAEPDISNKSR-ETPLYKACERKNAEAVRILVQYNADAN-- 232
Cdd:PHA02878 120 ILTNRYKNIQTIDLVYIDKKSKDDIIEAEITKLL--LSYGADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNip 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  233 HRCNRgwTALHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLFVAAQS-GQLEALRFLAKHGADINTQAS-DSASALYE 310
Cdd:PHA02878 198 DKTNN--SPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYiLGLTALHS 275

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 58865544  311 ACKNEheDVVEFLLSQGADANKANKDGLLPLHVASKK 347
Cdd:PHA02878 276 SIKSE--RKLKLLLEYGADINSLNSYKLTPLSSAVKQ 310
Ank_2 pfam12796
Ankyrin repeats (3 copies);
308-397 1.88e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.46  E-value: 1.88e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544   308 LYEACKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLLPvTSRTRVRRSGISPLHLAAERNHDAVLEA 387
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|
gi 58865544   388 LLAARFDVNT 397
Cdd:pfam12796  80 LLEKGADINV 89
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 199-399 4.80e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 83.86  E-value: 4.80e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  199 DISNKSRETPLYKACERKNAEAVRILVQYNADANHRC----NRGWTALheSVSRNDL---------------------EV 253
Cdd:PHA02874  29 NISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINtkipHPLLTAI--KIGAHDIikllidngvdtsilpipciekDM 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  254 MEILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLSQGADANKA 333
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 58865544  334 NKDGLLPLHVASKKGNYRIVQMLLPVTSRTRVR-RSGISPLHLAAERNHDAVlEALLAARF----DVN--TPL 399
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKcKNGFTPLHNAIIHNRSAI-ELLINNASindqDIDgsTPL 258
Ank_2 pfam12796
Ankyrin repeats (3 copies);
275-357 9.57e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 75.54  E-value: 9.57e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544   275 LFVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLSQgADANKANkDGLLPLHVASKKGNYRIVQ 354
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ...
gi 58865544   355 MLL 357
Cdd:pfam12796  79 LLL 81
Ank_2 pfam12796
Ankyrin repeats (3 copies);
242-334 1.35e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 75.15  E-value: 1.35e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544   242 LHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHgADINTQASDSaSALYEACKNEHEDVVE 321
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 58865544   322 FLLSQGADANKAN 334
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 184-463 3.66e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 81.46  E-value: 3.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  184 HLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVR-ILVQYNadanhRCNRGWT--ALHESVSRNDLEVMEILVSG 260
Cdd:PHA02878  49 NLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKeMIRSIN-----KCSVFYTlvAIKDAFNNRNVEIFKIILTN 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  261 gakvEAKNVYSITPLFVAAQSG----QLEALRFLAKHGADINTQASDS-ASALYEACKNEHEDVVEFLLSQGADANKANK 335
Cdd:PHA02878 124 ----RYKNIQTIDLVYIDKKSKddiiEAEITKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNIPDK 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  336 DGLLPLHVASKKGNYRIVQMLLPVTSRTRVRRS-GISPLHLAAERNHD-AVLEALLAARFDVNtplaperARLYeDRRTS 413
Cdd:PHA02878 200 TNNSPLHHAVKHYNKPIVHILLENGASTDARDKcGNTPLHISVGYCKDyDILKLLLEHGVDVN-------AKSY-ILGLT 271

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 58865544  414 ALYFAVVNNNVyaTELLLLAGADPNR---DVISPLLVAIR-HGCLRTMQLLLDH 463
Cdd:PHA02878 272 ALHSSIKSERK--LKLLLEYGADINSlnsYKLTPLSSAVKqYLCINIGRILISN 323
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 109-367 4.90e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 81.65  E-value: 4.90e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  109 VLKAIKEGDEEALKAMIQDGKNLAEPNKEGWLPLHEAAYYGKLGCL--KVLQRAypGTIDQRTLQEETALYL-ATCREHL 185
Cdd:PHA02876 244 LLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRLvpKLLERG--ADVNAKNIKGETPLYLmAKNGYDT 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  186 DCLLSLLQAGAEPDISNKSRETPLYKACE-RKNAEAVRILVQYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKV 264
Cdd:PHA02876 322 ENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADI 401

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  265 EAKNVYSITPL-FVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHE-DVVEFLLSQGADANKANKDGLLPLH 342
Cdd:PHA02876 402 EALSQKIGTALhFALCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNCKlDVIEMLLDNGADVNAINIQNQYPLL 481

                        250       260
                 ....*....|....*....|....*
gi 58865544  343 VAskKGNYRIVQMLLPVTSRTRVRR 367
Cdd:PHA02876 482 IA--LEYHGIVNILLHYGAELRDSR 504
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 108-298 9.27e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 79.65  E-value: 9.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  108 PVLKAIKEGDEEALKAMIQDGK--NLAEPNKEGwlPLHEAAYYGKLGCLKVLQRAYPGTIDQRTLQEETALYLATCREHL 185
Cdd:PHA02875  38 PIKLAMKFRDSEAIKLLMKHGAipDVKYPDIES--ELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  186 DCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVQYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVE 265
Cdd:PHA02875 116 DIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANID 195

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 58865544  266 --AKNVySITPLFVAAQSGQLEALRFLAKHGADIN 298
Cdd:PHA02875 196 yfGKNG-CVAALCYAIENNKIDIVRLFIKRGADCN 229
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 185-396 2.65e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 78.49  E-value: 2.65e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  185 LDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVQYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKv 264
Cdd:PHA02875  15 LDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKF- 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  265 eAKNVY---SITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLSQGADANKANKDGLLPL 341
Cdd:PHA02875  94 -ADDVFykdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPL 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 58865544  342 HVASKKGNYRIVQMLLPVTSRTRV--RRSGISPLHLAAERNHDAVLEALLAARFDVN 396
Cdd:PHA02875 173 IIAMAKGDIAICKMLLDSGANIDYfgKNGCVAALCYAIENNKIDIVRLFIKRGADCN 229
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 188-336 6.78e-15

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 78.37  E-value: 6.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  188 LLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVQYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAkveAK 267
Cdd:PLN03192 541 LEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFAS---IS 617

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  268 NVYSITPLF-VAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLSQGADANKANKD 336
Cdd:PLN03192 618 DPHAAGDLLcTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 242-501 1.08e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 77.41  E-value: 1.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  242 LHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASA-------------- 307
Cdd:PHA02876 149 IKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVlecavdsknidtik 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  308 ------------------------------LYEA---------CKNE--HEDV--------VEFLLSQGADANKANKDGL 338
Cdd:PHA02876 229 aiidnrsninkndlsllkairnedletsllLYDAgfsvnsiddCKNTplHHASqapslsrlVPKLLERGADVNAKNIKGE 308

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  339 LPLHVASKKG----NYRIVQMLLPVTSRTrvRRSGISPLHLAA--ERNHDAVLeALLAARFDVNtplaperARLYEDRrt 412
Cdd:PHA02876 309 TPLYLMAKNGydteNIRTLIMLGADVNAA--DRLYITPLHQAStlDRNKDIVI-TLLELGANVN-------ARDYCDK-- 376

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  413 SALYFAVVNNNVYATELLLLAGADPnrDVISPLLVAIRHGCL------RTMQLLLDHGANIDA---YIAThptafPATIM 483
Cdd:PHA02876 377 TPIHYAAVRNNVVIINTLLDYGADI--EALSQKIGTALHFALcgtnpyMSVKTLIDRGANVNSknkDLST-----PLHYA 449

                        330
                 ....*....|....*....
gi 58865544  484 FAMKC-LSLLKFLMDLGCD 501
Cdd:PHA02876 450 CKKNCkLDVIEMLLDNGAD 468
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 590-631 7.81e-14

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 65.59  E-value: 7.81e-14
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 58865544 590 EPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYE 631
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 592-631 1.29e-13

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 65.18  E-value: 1.29e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 58865544 592 PRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYE 631
Cdd:cd03587   2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 278-475 2.78e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.95  E-value: 2.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  278 AAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLL 357
Cdd:PHA02875   9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  358 PVTSRTR--VRRSGISPLHLAAERNHDAVLEALLAARFDVNTPlaperarlyEDRRTSALYFAVVNNNVYATELLLLAGA 435
Cdd:PHA02875  89 DLGKFADdvFYKDGMTPLHLATILKKLDIMKLLIARGADPDIP---------NTDKFSPLHLAVMMGDIKGIELLIDHKA 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 58865544  436 DPNRD---VISPLLVAIRHGCLRTMQLLLDHGANIDaYIATHP 475
Cdd:PHA02875 160 CLDIEdccGCTPLIIAMAKGDIAICKMLLDSGANID-YFGKNG 201
PHA03095 PHA03095
ankyrin-like protein; Provisional
 110-358 8.48e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 70.82  E-value: 8.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  110 LKAIKEGDEEALKAMIQDGKNLAEPNKEGWLPLHEAAYYG-KLGCLKVLQRA-----YPGTIDQRTLQeetaLYLATCRE 183
Cdd:PHA03095  55 LHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNAtTLDVIKLLIKAgadvnAKDKVGRTPLH----VYLSGFNI 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  184 HLDCLLSLLQAGAEPDISNKSRETPLYKACERKNA--EAVRILVQYNADANHRCNRGWTALH---ESVsRNDLEVMEILV 258
Cdd:PHA03095 131 NPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNAnvELLRLLIDAGADVYAVDDRFRSLLHhhlQSF-KPRARIVRELI 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  259 SGGAKVEAKNVYSITPLFVAAQSGQLEA--LRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLSQGADANKANKD 336
Cdd:PHA03095 210 RAGCDPAATDMLGNTPLHSMATGSSCKRslVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSD 289

                        250       260
                 ....*....|....*....|..
gi 58865544  337 GLLPLHVASKKGNYRIVQMLLP 358
Cdd:PHA03095 290 GNTPLSLMVRNNNGRAVRAALA 311
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 591-629 3.32e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 58.33  E-value: 3.32e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 58865544   591 PPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLK 629
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
112-202 6.74e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.97  E-value: 6.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544   112 AIKEGDEEALKAMIQDGKNLAEPNKEGWLPLHEAAYYGKLGCLKVLQRAYPGtidQRTLQEETALYLATCREHLDCLLSL 191
Cdd:pfam12796   4 AAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV---NLKDNGRTALHYAARSGHLEIVKLL 80

                          90
                  ....*....|.
gi 58865544   192 LQAGAEPDISN 202
Cdd:pfam12796  81 LEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 271-467 1.12e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.21  E-value: 1.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  271 SITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLSQGADANkankdgLLPLHVASKKGNY 350
Cdd:PHA02874  35 TTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTS------ILPIPCIEKDMIK 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  351 RIVQMLLPVTSRTRVRRSGispLHLAAERNHDAVLEALLAARFDVNtplaperarLYEDRRTSALYFAVVNNNVYATELL 430
Cdd:PHA02874 109 TILDCGIDVNIKDAELKTF---LHYAIKKGDLESIKMLFEYGADVN---------IEDDNGCYPIHIAIKHNFFDIIKLL 176

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 58865544  431 LLAGADPN---RDVISPLLVAIRHGCLRTMQLLLDHGANI 467
Cdd:PHA02874 177 LEKGAYANvkdNNGESPLHNAAEYGDYACIKLLIDHGNHI 216
Ank_4 pfam13637
Ankyrin repeats (many copies);
273-324 3.77e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.74  E-value: 3.77e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 58865544   273 TPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLL 324
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
306-357 4.59e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.36  E-value: 4.59e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 58865544   306 SALYEACKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLL 357
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
373-469 5.22e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.28  E-value: 5.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544   373 LHLAAERNHDAVLEALLAARFDVNtplaperarLYEDRRTSALYFAVVNNNVYATELLLlAGADPNRDVI--SPLLVAIR 450
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADAN---------LQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKDNgrTALHYAAR 70

                          90
                  ....*....|....*....
gi 58865544   451 HGCLRTMQLLLDHGANIDA 469
Cdd:pfam12796  71 SGHLEIVKLLLEKGADINV 89
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 140-357 1.43e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 60.80  E-value: 1.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 140 LPLHEAAYYGKLGCLKVLQRAYPGTIDQRTLQEETALYLATCREHLDCLLSLLQAGaePDISNKSRETPLYKacerknae 219
Cdd:cd22192  19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAA--PELVNEPMTSDLYQ-------- 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 220 avrilvqynadanhrcnrGWTALHESVSRNDLEVMEILVSGGAKV------------EAKNV--YSITPLFVAAQSGQLE 285
Cdd:cd22192  89 ------------------GETALHIAVVNQNLNLVRELIARGADVvspratgtffrpGPKNLiyYGEHPLSFAACVGNEE 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 286 ALRFLAKHGADINTQASDSASALY----EACKNEHEDVVEFLLSQGADANKA------NKDGLLPLHVASKKGNYRIVQM 355
Cdd:cd22192 151 IVRLLIEHGADIRAQDSLGNTVLHilvlQPNKTFACQMYDLILSYDKEDDLQpldlvpNNQGLTPFKLAAKEGNIVMFQH 230


                ..
gi 58865544 356 LL 357
Cdd:cd22192 231 LV 232
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 300-469 9.51e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 57.97  E-value: 9.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  300 QASDSASA-----LYEACKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLLPVTSRTRV--------- 365
Cdd:PHA02878  28 NYSTSASLipfipLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVfytlvaikd 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  366 ----------------RRSGISPLHLAA--ERNHDAVLEA-----LLAARFDVNtplaperaRLYEDRRTSALYFAVVNN 422
Cdd:PHA02878 108 afnnrnveifkiiltnRYKNIQTIDLVYidKKSKDDIIEAeitklLLSYGADIN--------MKDRHKGNTALHYATENK 179

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 58865544  423 NVYATELLLLAGADPN---RDVISPLLVAIRHGCLRTMQLLLDHGANIDA 469
Cdd:PHA02878 180 DQRLTELLLSYGANVNipdKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 202-348 1.82e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 55.21  E-value: 1.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  202 NKSRETPLYKACERKNA--EAVRILVQYNADANHRC-NRGWTALHESVSRN---DLEVMEILVSGGAKVEAKNVYSITPL 275
Cdd:PHA02859  48 NDLYETPIFSCLEKDKVnvEILKFLIENGADVNFKTrDNNLSALHHYLSFNknvEPEILKILIDSGSSITEEDEDGKNLL 127

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 58865544  276 --FVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHED-VVEFLLSQGADANKANKDGLLPLHVASKKG 348
Cdd:PHA02859 128 hmYMCNFNVRINVIKLLIDSGVSFLNKDFDNNNILYSYILFHSDKkIFDFLTSLGIDINETNKSGYNCYDLIKFRN 203
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 175-299 2.14e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 56.98  E-value: 2.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  175 ALYLATCREHLDCLLSLLQAGAEPDISNKSRETPL--YKACERKNAEAVRILVQYNADANHRC----------------N 236
Cdd:PHA03100 111 LYAISKKSNSYSIVEYLLDNGANVNIKNSDGENLLhlYLESNKIDLKILKLLIDKGVDINAKNrvnyllsygvpinikdV 190

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 58865544  237 RGWTALHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINT 299
Cdd:PHA03100 191 YGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 593-631 3.41e-08

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 49.71  E-value: 3.41e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 58865544    593 RPLAHLCRLRVRKAIGKyriklLDTLPLPGRLIRYLKYE 631
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 108-292 4.91e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 56.17  E-value: 4.91e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 108 PVLKAIKEGDEEALKAMI-QDGKNLAEPNKEGWLPLHEAAYYGKLGCLKVLQRAYPGTIDQRTLQE----ETALYLATCR 182
Cdd:cd22192  20 PLLLAAKENDVQAIKKLLkCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELVNEPMTSDlyqgETALHIAVVN 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 183 EHLDCLLSLLQAGAepDISN---------KSR-------ETPL-YKACErKNAEAVRILVQYNADANHRCNRGWTALHES 245
Cdd:cd22192 100 QNLNLVRELIARGA--DVVSpratgtffrPGPknliyygEHPLsFAACV-GNEEIVRLLIEHGADIRAQDSLGNTVLHIL 176

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 58865544 246 VSRND----LEVMEILVSGGAKVEAKNVYSI------TPLFVAAQSGQLEALRFLAK 292
Cdd:cd22192 177 VLQPNktfaCQMYDLILSYDKEDDLQPLDLVpnnqglTPFKLAAKEGNIVMFQHLVQ 233
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 592-631 5.14e-08

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 49.22  E-value: 5.14e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 58865544 592 PRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYE 631
Cdd:cd03718   3 PLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLYQ 42
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 279-357 5.42e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 56.06  E-value: 5.42e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 58865544  279 AQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLL 357
Cdd:PTZ00322  90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 592-631 1.19e-07

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 48.19  E-value: 1.19e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 58865544 592 PRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYE 631
Cdd:cd03720   3 PRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 590-631 1.45e-07

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 48.30  E-value: 1.45e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 58865544 590 EPPRPLAHLCRLRVRKAIGKYRIK---LLDTLPLPGRLIRYLKYE 631
Cdd:cd03730   1 TNPRSLKHLCRLKIRACMGRLRLRcpvFMSFLPLPNRLKAYILYK 45
Ank_4 pfam13637
Ankyrin repeats (many copies);
205-258 2.01e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.04  E-value: 2.01e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 58865544   205 RETPLYKACERKNAEAVRILVQYNADANHRCNRGWTALHESVSRNDLEVMEILV 258
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 592-631 2.87e-07

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 47.26  E-value: 2.87e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 58865544 592 PRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYE 631
Cdd:cd03743   3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 592-630 3.14e-07

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 46.82  E-value: 3.14e-07
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 58865544 592 PRPLAHLCRLRVRKAIGKYRIkllDTLPLPGRLIRYLKY 630
Cdd:cd03717   3 VRSLQHLCRFVIRQCTRRDLI---DQLPLPRRLKDYLKE 38
PHA02798 PHA02798
ankyrin-like protein; Provisional
 221-450 3.86e-07

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 52.91  E-value: 3.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  221 VRILVQYNADANHRCNRGWTALHESVSR---NDLEVMEILVSGGAKVEAKNVYSITPLFVAAQSG---QLEALRFLAKHG 294
Cdd:PHA02798  92 VKILIENGADINKKNSDGETPLYCLLSNgyiNNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNhhiDIEIIKLLLEKG 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  295 ADINTQAS----DSASALYEACKNEHE-DVVEFLLSQGADANKANK-------DGLLPLHVASKKGNYRIVQMLLPVTSR 362
Cdd:PHA02798 172 VDINTHNNkekyDTLHCYFKYNIDRIDaDILKLFVDNGFIINKENKshkkkfmEYLNSLLYDNKRFKKNILDFIFSYIDI 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  363 TRVRRSGISPLHLAAERNHDAVLEALLAARFDVN--TPLAperarlyedrrTSALYFAVVNNNVYATELLLlaGADPNRD 440
Cdd:PHA02798 252 NQVDELGFNPLYYSVSHNNRKIFEYLLQLGGDINiiTELG-----------NTCLFTAFENESKFIFNSIL--NKKPNKN 318

                        250
                 ....*....|
gi 58865544  441 VISPLLVAIR 450
Cdd:PHA02798 319 TISYTYYKLR 328
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 237-357 5.61e-07

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 52.78  E-value: 5.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544   237 RGWTALHESVSRNDLEVMEILVSGGAKVEAKNV--------------YSITPLFVAAQSGQLEALRFLAKHGADINTQAS 302
Cdd:TIGR00870 127 PGITALHLAAHRQNYEIVKLLLERGASVPARACgdffvksqgvdsfyHGESPLNAAACLGSPSIVALLSEDPADILTADS 206

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58865544   303 DS-----ASALYEACKNEHEDVV----EFLLSQGADANKA-------NKDGLLPLHVASKKGNYRIVQMLL 357
Cdd:TIGR00870 207 LGntllhLLVMENEFKAEYEELScqmyNFALSLLDKLRDSkelevilNHQGLTPLKLAAKEGRIVLFRLKL 277
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
 593-632 7.35e-07

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 46.24  E-value: 7.35e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 58865544 593 RPLAHLCRLRVRKAIgkyRIKLLDTLPLPGRLIRYLKYEN 632
Cdd:cd03741   4 QSLQHLCRFVIRKLV---RRDHIPALPLPRRLIDYLREKH 40
Ank_4 pfam13637
Ankyrin repeats (many copies);
106-157 9.00e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 9.00e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 58865544   106 MDPVLKAIKEGDEEALKAMIQDGKNLAEPNKEGWLPLHEAAYYGKLGCLKVL 157
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 151-357 1.82e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 51.03  E-value: 1.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 151 LGCLKVLQRAYPGTIDQRTLQEETALYLATCREH---LDCLLSLLQAGaepdisnksretplykacerKNAEAVRILVqy 227
Cdd:cd21882   5 LGLLECLRWYLTDSAYQRGATGKTCLHKAALNLNdgvNEAIMLLLEAA--------------------PDSGNPKELV-- 62

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 228 NADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNV-------------YSITPLFVAAQSGQLEALRFLAKHG 294
Cdd:cd21882  63 NAPCTDEFYQGQTALHIAIENRNLNLVRLLVENGADVSARATgrffrkspgnlfyFGELPLSLAACTNQEEIVRLLLENG 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 295 ADI-NTQASDSAS-----ALYEACKNEHED------VVEFLLSQGADANK-------ANKDGLLPLHVASKKGNYRIVQM 355
Cdd:cd21882 143 AQPaALEAQDSLGntvlhALVLQADNTPENsafvcqMYNLLLSYGAHLDPtqqleeiPNHQGLTPLKLAAVEGKIVMFQH 222


                ..
gi 58865544 356 LL 357
Cdd:cd21882 223 IL 224
Ank_5 pfam13857
Ankyrin repeats (many copies);
191-243 1.93e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.42  E-value: 1.93e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 58865544   191 LLQAG-AEPDISNKSRETPLYKACERKNAEAVRILVQYNADANHRCNRGWTALH 243
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 586-630 2.51e-06

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 44.59  E-value: 2.51e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 58865544    586 KEKAEPPRPLAHLCRLRVRKAIGKYRIKlldTLPLPGRLIRYLKY 630
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIK---TLPLPPKLKDYLSY 42
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 242-436 2.79e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 50.64  E-value: 2.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  242 LHESVSRNDLEVMEILVSGGAkvEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVE 321
Cdd:PLN03192 498 LQHHKELHDLNVGDLLGDNGG--EHDDPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVL 575

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  322 FLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLLPVTSRTRVRRSGiSPLHLAAERNHDAVLEALLAARFDVNTplap 401
Cdd:PLN03192 576 VLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISDPHAAG-DLLCTAAKRNDLTAMKELLKQGLNVDS---- 650

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 58865544  402 erarlyEDRR-TSALYFAVVNNNVYATELLLLAGAD 436
Cdd:PLN03192 651 ------EDHQgATALQVAMAEDHVDMVRLLIMNGAD 680
PHA02946 PHA02946
ankyin-like protein; Provisional
 175-375 3.85e-06

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 49.67  E-value: 3.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  175 ALYLATCREHLDCLLSLLQAgAEPdiSNKSRETPLYKACERKNAEAVRILVQYNADANHRCNRGWTALHESVSRNDLEVM 254
Cdd:PHA02946  12 SLYAKYNSKNLDVFRNMLQA-IEP--SGNYHILHAYCGIKGLDERFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  255 EILVSGGAKVEAKNVYSITPLFVAAQSGQ--LEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLSQGADA-- 330
Cdd:PHA02946  89 AMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAKINNSVDEEGCGPLLACTDPSERVFKKIMSIGFEAri 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  331 ---------------------------------NKANKDGLLPLHVASKK--GNYRIVQMLLPVTSRTRVRRSGISPLHL 375
Cdd:PHA02946 169 vdkfgknhihrhlmsdnpkastiswmmklgispSKPDHDGNTPLHIVCSKtvKNVDIINLLLPSTDVNKQNKFGDSPLTL 248
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 339-486 7.47e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.86  E-value: 7.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 339 LPLHVASKKGNYRIVQMLLpVTSRTRVRRSGI---SPLHLAAERNHDAVLEALL-AARFDVNTPLAPErarLYEDRrtSA 414
Cdd:cd22192  19 SPLLLAAKENDVQAIKKLL-KCPSCDLFQRGAlgeTALHVAALYDNLEAAVVLMeAAPELVNEPMTSD---LYQGE--TA 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 415 LYFAVVNNNVYATELLLLAGAD------------PNRDVI-----SPLLVAIRHGCLRTMQLLLDHGANIDA-------- 469
Cdd:cd22192  93 LHIAVVNQNLNLVRELIARGADvvspratgtffrPGPKNLiyygeHPLSFAACVGNEEIVRLLIEHGADIRAqdslgntv 172

                       170
                ....*....|....*....
gi 58865544 470 --YIATHPTAFPATIMFAM 486
Cdd:cd22192 173 lhILVLQPNKTFACQMYDL 191
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 590-631 9.20e-06

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 43.09  E-value: 9.20e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 58865544 590 EPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYE 631
Cdd:cd03719   1 AEPHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYLLYQ 42
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 592-631 9.55e-06

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 43.05  E-value: 9.55e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 58865544 592 PRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYE 631
Cdd:cd03744   3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLYQ 42
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 590-631 1.17e-05

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 42.90  E-value: 1.17e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 58865544 590 EPPRPLAHLCRLRVRKAIGKYRIKLLDT---LPLPGRLIRYLKYE 631
Cdd:cd03731   1 ENPRPLKHLCRLKIRKLMGLQKLQQPSSmkkLPLPPALKRYILYK 45
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 406-503 1.40e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 47.29  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  406 LYEDRRTSALYFAVVNNNVYATELLLLAGADPNR----DVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPAT 481
Cdd:PHA02884  65 LSENSKTNPLIYAIDCDNDDAAKLLIRYGADVNRyaeeAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELA 144

                         90       100
                 ....*....|....*....|..
gi 58865544  482 IMFamkCLSLLKFLMdlgCDGE 503
Cdd:PHA02884 145 LMI---CNNFLAFMI---CDNE 160
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 219-357 1.43e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 48.22  E-value: 1.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 219 EAVRILVQY-----------NADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKN--------------VYSIT 273
Cdd:cd22194 111 EIVRILLAFaeengildrfiNAEYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNAHAkgvffnpkykhegfYFGET 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 274 PLFVAAQSGQLEALRFLAKHGADINTqASDSAS-----ALYEACKN--EHEDVV----EFLLSQGADAN---KANKDGLL 339
Cdd:cd22194 191 PLALAACTNQPEIVQLLMEKESTDIT-SQDSRGntvlhALVTVAEDskTQNDFVkrmyDMILLKSENKNletIRNNEGLT 269

                       170
                ....*....|....*...
gi 58865544 340 PLHVASKKGNYRIVQMLL 357
Cdd:cd22194 270 PLQLAAKMGKAEILKYIL 287
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 592-630 3.92e-05

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 41.31  E-value: 3.92e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 58865544 592 PRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKY 630
Cdd:cd03729   3 PLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSY 41
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 592-630 4.10e-05

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 41.02  E-value: 4.10e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 58865544 592 PRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKY 630
Cdd:cd03724   3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQY 41
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 592-631 5.30e-05

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 40.99  E-value: 5.30e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 58865544 592 PRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYE 631
Cdd:cd03726   3 PRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHK 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
238-290 7.92e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 7.92e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 58865544   238 GWTALHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFL 290
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 108-225 1.24e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.87  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  108 PVLKAIKEGDEEALKAMIQDGKNLAEPNKEGWLPLHEAAYYGK-LGCLKVLQRAYPGTIDQRTLQEETALYLATCREhlD 186
Cdd:PHA02878 204 PLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYCKdYDILKLLLEHGVDVNAKSYILGLTALHSSIKSE--R 281

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 58865544  187 CLLSLLQAGAEPDISNKSRETPLYKAC-ERKNAEAVRILV 225
Cdd:PHA02878 282 KLKLLLEYGADINSLNSYKLTPLSSAVkQYLCINIGRILI 321
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 268-352 1.75e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 43.27  E-value: 1.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  268 NVYSITPLF--VAAQSGQLEALRFLAKHGADINTQASDSA-SALYEAC---KNEHEDVVEFLLSQGADANKANKDGLLPL 341
Cdd:PHA02859  48 NDLYETPIFscLEKDKVNVEILKFLIENGADVNFKTRDNNlSALHHYLsfnKNVEPEILKILIDSGSSITEEDEDGKNLL 127

                         90
                 ....*....|.
gi 58865544  342 HVASKKGNYRI 352
Cdd:PHA02859 128 HMYMCNFNVRI 138
Ank_4 pfam13637
Ankyrin repeats (many copies);
174-225 1.85e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 1.85e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 58865544   174 TALYLATCREHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILV 225
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 237-357 3.91e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 43.64  E-value: 3.91e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 237 RGWTALHESVSRNDLEVMEILVSGGAKVEAKN--------------VYSITPLFVAAQSGQLEALRFLAKH---GADINt 299
Cdd:cd22196  93 KGQTALHIAIERRNMHLVELLVQNGADVHARAsgeffkkkkggpgfYFGELPLSLAACTNQLDIVKFLLENphsPADIS- 171

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58865544 300 qASDSAS-----ALYEACKNEHEDvVEF-------LLSQGADANK-------ANKDGLLPLHVASKKGNYRIVQMLL 357
Cdd:cd22196 172 -ARDSMGntvlhALVEVADNTPEN-TKFvtkmyneILILGAKIRPllkleeiTNKKGLTPLKLAAKTGKIGIFAYIL 246
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 592-632 4.11e-04

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 38.58  E-value: 4.11e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 58865544 592 PRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYEN 632
Cdd:cd03723   3 PRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLLLEP 43
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 237-357 4.69e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 43.25  E-value: 4.69e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 237 RGWTALHESVSRNDLEVMEILVSGGAKVEAKN--------------VYSITPLFVAAQSGQLEALRFLAKHG-ADINTQA 301
Cdd:cd22193  75 EGQTALHIAIERRQGDIVALLVENGADVHAHAkgrffqpkyqgegfYFGELPLSLAACTNQPDIVQYLLENEhQPADIEA 154

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 58865544 302 SDSAS-----ALYEACKNEHED------VVEFLLSQGADANKA-------NKDGLLPLHVASKKGNYRIVQMLL 357
Cdd:cd22193 155 QDSRGntvlhALVTVADNTKENtkfvtrMYDMILIRGAKLCPTveleeirNNDGLTPLQLAAKMGKIEILKYIL 228
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 176-278 9.37e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 41.51  E-value: 9.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  176 LYLATCREHLDCLLSLLQAGAEPDI----SNKSRETPLYKACERKNAEAVRILVQYNADANHRCNRG-WTALHESVSRND 250
Cdd:PHA02884  37 LYSSIKFHYTDIIDAILKLGADPEApfplSENSKTNPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAkITPLYISVLHGC 116

                         90       100
                 ....*....|....*....|....*...
gi 58865544  251 LEVMEILVSGGAKVEAKNVYSITPLFVA 278
Cdd:PHA02884 117 LKCLEILLSYGADINIQTNDMVTPIELA 144
Ank_5 pfam13857
Ankyrin repeats (many copies);
290-344 1.03e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.71  E-value: 1.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 58865544   290 LAKHG-ADINTQASDSASALYEACKNEHEDVVEFLLSQGADANKANKDGLLPLHVA 344
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02798 PHA02798
ankyrin-like protein; Provisional
 250-397 1.17e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 41.74  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  250 DLEVMEILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHE-----DVVEFLL 324
Cdd:PHA02798  17 KLSTVKLLIKSCNPNEIVNEYSIFQKYLQRDSPSTDIVKLFINLGANVNGLDNEYSTPLCTILSNIKDykhmlDIVKILI 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  325 SQGADANKANKDGLLPLHVASKKG---NYRIVQ-MLLPVTSRTRVRRSGISPLHLAAERNHDA---VLEALLAARFDVNT 397
Cdd:PHA02798  97 ENGADINKKNSDGETPLYCLLSNGyinNLEILLfMIENGADTTLLDKDGFTMLQVYLQSNHHIdieIIKLLLEKGVDINT 176
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 256-325 1.42e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.81  E-value: 1.42e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  256 ILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLS 325
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 273-298 1.71e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 1.71e-03
                           10        20
                   ....*....|....*....|....*.
gi 58865544    273 TPLFVAAQSGQLEALRFLAKHGADIN 298
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 273-299 2.58e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.70  E-value: 2.58e-03
                          10        20
                  ....*....|....*....|....*..
gi 58865544   273 TPLFVAAQSGQLEALRFLAKHGADINT 299
Cdd:pfam13606   4 TPLHLAARNGRLEIVKLLLENGADINA 30
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
108-209 3.29e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 39.94  E-value: 3.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 108 PVLKAIKEGDEEALKAMIQDGKNLAEPNKEGWLPLHEAAYYGKLGCLKVLQRAYpGTIDQRTLQEETALYLATCREHLDC 187
Cdd:COG0666 189 PLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG-ADLNAKDKDGLTALLLAAAAGAALI 267

                        90       100
                ....*....|....*....|..
gi 58865544 188 LLSLLQAGAEPDISNKSRETPL 209
Cdd:COG0666 268 VKLLLLALLLLAAALLDLLTLL 289
Ank_5 pfam13857
Ankyrin repeats (many copies);
323-376 3.37e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.17  E-value: 3.37e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 58865544   323 LLSQG-ADANKANKDGLLPLHVASKKGNYRIVQMLL-PVTSRTRVRRSGISPLHLA 376
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLaYGVDLNLKDEEGLTALDLA 56
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 243-324 4.72e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 39.72  E-value: 4.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544  243 HESVSRNDLEVMEILVSGgAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEF 322
Cdd:PHA02989 229 NKILSKKEFKVLNFILKY-IKINKKDKKGFNPLLISAKVDNYEAFNYLLKLGDDIYNVSKDGDTVLTYAIKHGNIDMLNR 307


                 ..
gi 58865544  323 LL 324
Cdd:PHA02989 308 IL 309
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 369-396 5.13e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 5.13e-03
                           10        20
                   ....*....|....*....|....*...
gi 58865544    369 GISPLHLAAERNHDAVLEALLAARFDVN 396
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 171-290 5.34e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 39.78  E-value: 5.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 171 QEETALYLATCREHLDCLLSLLQAGAEPDISNKSR--------------ETPLYKACERKNAEAVRILVQ---YNADANH 233
Cdd:cd22193  75 EGQTALHIAIERRQGDIVALLVENGADVHAHAKGRffqpkyqgegfyfgELPLSLAACTNQPDIVQYLLEnehQPADIEA 154

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 58865544 234 RCNRGWTALH-------ESVSRNDL--EVMEILVSGGAKV-------EAKNVYSITPLFVAAQSGQLEALRFL 290
Cdd:cd22193 155 QDSRGNTVLHalvtvadNTKENTKFvtRMYDMILIRGAKLcptveleEIRNNDGLTPLQLAAKMGKIEILKYI 227
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 595-630 5.60e-03

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 35.09  E-value: 5.60e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 58865544 595 LAHLCRLRVRKAIGKYRIKlldTLPLPGRLIRYLKY 630
Cdd:cd03733   6 LQHLCRMALRRVMTTQQVL---ALPIPKKMKEFLTY 38
TRPV2 cd22197
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2; TRPV2 is closely ...
 228-357 6.02e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2; TRPV2 is closely related to TRPV1, sharing high sequence identity (>50%), but TRPV2 shows a higher temperature threshold and sensitivity for activation than TRPV1. TRPV2 can be stimulated by ligands or lipids, and is involved in osmosensation and mechanosensation. TRPV2 is expressed in both neuronal and non-neuronal tissues, and it has been implicated in diverse physiological and pathophysiological processes, including cardiac-structure maintenance, innate immunity, and cancer. TRPV2 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411981 [Multi-domain]  Cd Length: 640  Bit Score: 39.84  E-value: 6.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 228 NADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKN-------------VYSITPLFVAAQSGQLEALRFLAKHG 294
Cdd:cd22197  84 NAQCTDEYYRGHSALHIAIEKRSLQCVKLLVENGADVHARAcgrffqkkqgtcfYFGELPLSLAACTKQWDVVNYLLENP 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865544 295 ADI-NTQASDSAS-----ALYEACKNEHED---VVEF---LLSQGADANKA-------NKDGLLPLHVASKKGNYRIVQM 355
Cdd:cd22197 164 HQPaSLQAQDSLGntvlhALVMIADNSPENsalVIKMydgLLQAGARLCPTvqleeisNHEGLTPLKLAAKEGKIEIFRH 243


                ..
gi 58865544 356 LL 357
Cdd:cd22197 244 IL 245
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 237-266 8.48e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.10  E-value: 8.48e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 58865544    237 RGWTALHESVSRNDLEVMEILVSGGAKVEA 266
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 595-632 8.76e-03

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 34.77  E-value: 8.76e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 58865544 595 LAHLCRLRVRKAIGKYRIK---LLDTLPLPGRLIRYLKYEN 632
Cdd:cd03722   6 LTHLCRLEIRSSLKSERLRsdsFICQLPLPRSLQDYLLYSD 46
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 165-236 9.50e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 38.88  E-value: 9.50e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 58865544  165 IDQRTLQEETALYLATCREHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVQYNADANHRCN 236
Cdd:PHA03100 185 INIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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