NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|58865554|ref|NP_001011993|]
View 

pyrroline-5-carboxylate reductase 3 [Rattus norvegicus]

Protein Classification

pyrroline-5-carboxylate reductase family protein( domain architecture ID 11417420)

pyrroline-5-carboxylate reductase family protein similar to pyrroline-5-carboxylate reductase that catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline

CATH:  1.10.3730.10|3.40.50.720
EC:  1.-.-.-
Gene Ontology:  GO:0004735|GO:0055129

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 8-273 4.74e-99

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


:

Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 290.81  E-value: 4.74e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   8 PRRVGFVGAGRMAEAIAQGLIRAGkVEAKQVLASAPTDKNLCHFRA-LGCQTTHSNHEVLQNCPLVIFATKPQVLPAVLA 86
Cdd:COG0345   2 SMKIGFIGAGNMGSAIIKGLLKSG-VPPEDIIVSDRSPERLEALAErYGVRVTTDNAEAAAQADVVVLAVKPQDLAEVLE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554  87 EVAPVVTTEHIIVSVAAGISLSSMEELLPPKTRVLRVSPNLPCVVQEGAMVMTRGHHAGNEDAKLLQNLLEACGQCIEVP 166
Cdd:COG0345  81 ELAPLLDPDKLVISIAAGVTLATLEEALGGGAPVVRAMPNTPALVGEGVTALAAGEAVSEEDRELVEALFSAVGKVVWVD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554 167 ESYVDIHTGLSGSGVAFVCTFSEALAEGAIKMGMPSDLAHRIAAQTLLGTAKMLQQEGKHPAQLRTDVLTPAGTTIHGLH 246
Cdd:COG0345 161 EELMDAVTALSGSGPAYVFLFIEAMADAGVALGLPRETARELAAQTVLGAAKLLLESGEHPAELRDRVTSPGGTTIAGLK 240

                       250       260
                ....*....|....*....|....*..
gi 58865554 247 ALEQGGFRAAAMSAVEAATCRAKELSK 273
Cdd:COG0345 241 VLEEGGLRAAVIEAVEAAAERSKELGK 267
 
Name Accession Description Interval E-value
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 8-273 4.74e-99

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 290.81  E-value: 4.74e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   8 PRRVGFVGAGRMAEAIAQGLIRAGkVEAKQVLASAPTDKNLCHFRA-LGCQTTHSNHEVLQNCPLVIFATKPQVLPAVLA 86
Cdd:COG0345   2 SMKIGFIGAGNMGSAIIKGLLKSG-VPPEDIIVSDRSPERLEALAErYGVRVTTDNAEAAAQADVVVLAVKPQDLAEVLE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554  87 EVAPVVTTEHIIVSVAAGISLSSMEELLPPKTRVLRVSPNLPCVVQEGAMVMTRGHHAGNEDAKLLQNLLEACGQCIEVP 166
Cdd:COG0345  81 ELAPLLDPDKLVISIAAGVTLATLEEALGGGAPVVRAMPNTPALVGEGVTALAAGEAVSEEDRELVEALFSAVGKVVWVD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554 167 ESYVDIHTGLSGSGVAFVCTFSEALAEGAIKMGMPSDLAHRIAAQTLLGTAKMLQQEGKHPAQLRTDVLTPAGTTIHGLH 246
Cdd:COG0345 161 EELMDAVTALSGSGPAYVFLFIEAMADAGVALGLPRETARELAAQTVLGAAKLLLESGEHPAELRDRVTSPGGTTIAGLK 240

                       250       260
                ....*....|....*....|....*..
gi 58865554 247 ALEQGGFRAAAMSAVEAATCRAKELSK 273
Cdd:COG0345 241 VLEEGGLRAAVIEAVEAAAERSKELGK 267
PLN02688 PLN02688
pyrroline-5-carboxylate reductase
 10-273 9.04e-91

pyrroline-5-carboxylate reductase


Pssm-ID: 178291 [Multi-domain]  Cd Length: 266  Bit Score: 269.52  E-value: 9.04e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   10 RVGFVGAGRMAEAIAQGLIRAGKVEAKQVLASAPTDKNLC-HFRALGCQTTHSNHEVLQNCPLVIFATKPQVLPAVLAEV 88
Cdd:PLN02688   2 RVGFIGAGKMAEAIARGLVASGVVPPSRISTADDSNPARRdVFQSLGVKTAASNTEVVKSSDVIILAVKPQVVKDVLTEL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   89 APVVTTEHIIVSVAAGISLSSMEELLPPKtRVLRVSPNLPCVVQEGAMVMTRGHHAGNEDAKLLQNLLEACGQCIEVPES 168
Cdd:PLN02688  82 RPLLSKDKLLVSVAAGITLADLQEWAGGR-RVVRVMPNTPCLVGEAASVMSLGPAATADDRDLVATLFGAVGKIWVVDEK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554  169 YVDIHTGLSGSGVAFVCTFSEALAEGAIKMGMPSDLAHRIAAQTLLGTAKMLQQEGKHPAQLRTDVLTPAGTTIHGLHAL 248
Cdd:PLN02688 161 LLDAVTGLSGSGPAYIFLAIEALADGGVAAGLPRDVALSLAAQTVLGAAKMVLETGKHPGQLKDMVTSPGGTTIAGVHEL 240

                        250       260
                 ....*....|....*....|....*
gi 58865554  249 EQGGFRAAAMSAVEAATCRAKELSK 273
Cdd:PLN02688 241 EKGGFRAALMNAVVAAAKRSRELSK 265
proC TIGR00112
pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline ...
 27-270 3.15e-72

pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline biosynthesis. Among the four paralogs in Bacillus subtilis (proG, proH, proI, and comER), ComER is the most divergent and does not prevent proline auxotrophy from mutation of the other three. It is excluded from the seed and scores between the trusted and noise cutoffs. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 272911 [Multi-domain]  Cd Length: 245  Bit Score: 221.75  E-value: 3.15e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554    27 LIRAGKVEAKQVLASAP-TDKNLCHFRALGCQTTHSNHEVLQNCPLVIFATKPQVLPAVLAEVAPVVTTEHIIVSVAAGI 105
Cdd:TIGR00112   1 LLKAGALAPYDIYVINRsPEKLAALAKELGIVASSDAQEAVKEADVVFLAVKPQDLEEVLSELKSEKGKDKLLISIAAGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   106 SLSSMEELLPPKTRVLRVSPNLPCVVQEGAMVMTRGHHAGNEDAKLLQNLLEACGQCIEVPESYVDIHTGLSGSGVAFVC 185
Cdd:TIGR00112  81 TLEKLSQLLGGTRRVVRVMPNTPAKVGAGVTAIAANANVSEEDRALALALFKAVGSVVELPEALMDAVTALSGSGPAYVF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   186 TFSEALAEGAIKMGMPSDLAHRIAAQTLLGTAKMLQQEGKHPAQLRTDVLTPAGTTIHGLHALEQGGFRAAAMSAVEAAT 265
Cdd:TIGR00112 161 LFIEALADAGVKQGLPRELALELAAQTVKGAAKLLEESGEHPALLKDQVTSPGGTTIAGLAVLEEKGVRGAVIEAIEAAV 240


                  ....*
gi 58865554   266 CRAKE 270
Cdd:TIGR00112 241 RRSRE 245
P5CR_dimer pfam14748
Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of ...
 167-254 4.58e-37

Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of two domains, an N-terminal catalytic domain (pfam03807) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 464294 [Multi-domain]  Cd Length: 104  Bit Score: 126.74  E-value: 4.58e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   167 ESYVDIHTGLSGSGVAFVCTFSEALAEGAIKMGMPSDLAHRIAAQTLLGTAKMLQQEGKHPAQLRTDVLTPAGTTIHGLH 246
Cdd:pfam14748   1 ESLMDAVTALSGSGPAYVFLFIEALADAGVAMGLPREEARELAAQTVLGAAKLLLTSGEHPAELRDKVTSPGGTTIAGLA 80


                  ....*...
gi 58865554   247 ALEQGGFR 254
Cdd:pfam14748  81 VLEEGGFR 88
 
Name Accession Description Interval E-value
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 8-273 4.74e-99

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 290.81  E-value: 4.74e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   8 PRRVGFVGAGRMAEAIAQGLIRAGkVEAKQVLASAPTDKNLCHFRA-LGCQTTHSNHEVLQNCPLVIFATKPQVLPAVLA 86
Cdd:COG0345   2 SMKIGFIGAGNMGSAIIKGLLKSG-VPPEDIIVSDRSPERLEALAErYGVRVTTDNAEAAAQADVVVLAVKPQDLAEVLE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554  87 EVAPVVTTEHIIVSVAAGISLSSMEELLPPKTRVLRVSPNLPCVVQEGAMVMTRGHHAGNEDAKLLQNLLEACGQCIEVP 166
Cdd:COG0345  81 ELAPLLDPDKLVISIAAGVTLATLEEALGGGAPVVRAMPNTPALVGEGVTALAAGEAVSEEDRELVEALFSAVGKVVWVD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554 167 ESYVDIHTGLSGSGVAFVCTFSEALAEGAIKMGMPSDLAHRIAAQTLLGTAKMLQQEGKHPAQLRTDVLTPAGTTIHGLH 246
Cdd:COG0345 161 EELMDAVTALSGSGPAYVFLFIEAMADAGVALGLPRETARELAAQTVLGAAKLLLESGEHPAELRDRVTSPGGTTIAGLK 240

                       250       260
                ....*....|....*....|....*..
gi 58865554 247 ALEQGGFRAAAMSAVEAATCRAKELSK 273
Cdd:COG0345 241 VLEEGGLRAAVIEAVEAAAERSKELGK 267
PLN02688 PLN02688
pyrroline-5-carboxylate reductase
 10-273 9.04e-91

pyrroline-5-carboxylate reductase


Pssm-ID: 178291 [Multi-domain]  Cd Length: 266  Bit Score: 269.52  E-value: 9.04e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   10 RVGFVGAGRMAEAIAQGLIRAGKVEAKQVLASAPTDKNLC-HFRALGCQTTHSNHEVLQNCPLVIFATKPQVLPAVLAEV 88
Cdd:PLN02688   2 RVGFIGAGKMAEAIARGLVASGVVPPSRISTADDSNPARRdVFQSLGVKTAASNTEVVKSSDVIILAVKPQVVKDVLTEL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   89 APVVTTEHIIVSVAAGISLSSMEELLPPKtRVLRVSPNLPCVVQEGAMVMTRGHHAGNEDAKLLQNLLEACGQCIEVPES 168
Cdd:PLN02688  82 RPLLSKDKLLVSVAAGITLADLQEWAGGR-RVVRVMPNTPCLVGEAASVMSLGPAATADDRDLVATLFGAVGKIWVVDEK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554  169 YVDIHTGLSGSGVAFVCTFSEALAEGAIKMGMPSDLAHRIAAQTLLGTAKMLQQEGKHPAQLRTDVLTPAGTTIHGLHAL 248
Cdd:PLN02688 161 LLDAVTGLSGSGPAYIFLAIEALADGGVAAGLPRDVALSLAAQTVLGAAKMVLETGKHPGQLKDMVTSPGGTTIAGVHEL 240

                        250       260
                 ....*....|....*....|....*
gi 58865554  249 EQGGFRAAAMSAVEAATCRAKELSK 273
Cdd:PLN02688 241 EKGGFRAALMNAVVAAAKRSRELSK 265
PRK11880 PRK11880
pyrroline-5-carboxylate reductase; Reviewed
 9-274 6.16e-80

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 237008 [Multi-domain]  Cd Length: 267  Bit Score: 241.97  E-value: 6.16e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554    9 RRVGFVGAGRMAEAIAQGLIRAGkVEAKQVLASAPTDKNLCHFRA-LGCQTTHSNHEVLQNCPLVIFATKPQVLPAVLAE 87
Cdd:PRK11880   3 KKIGFIGGGNMASAIIGGLLASG-VPAKDIIVSDPSPEKRAALAEeYGVRAATDNQEAAQEADVVVLAVKPQVMEEVLSE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   88 VAPVVTTehIIVSVAAGISLSSMEELLPPKTRVLRVSPNLPCVVQEGAMVMTRGHHAGNEDAKLLQNLLEACGQCIEVP- 166
Cdd:PRK11880  82 LKGQLDK--LVVSIAAGVTLARLERLLGADLPVVRAMPNTPALVGAGMTALTANALVSAEDRELVENLLSAFGKVVWVDd 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554  167 ESYVDIHTGLSGSGVAFVCTFSEALAEGAIKMGMPSDLAHRIAAQTLLGTAKMLQQEGKHPAQLRTDVLTPAGTTIHGLH 246
Cdd:PRK11880 160 EKQMDAVTAVSGSGPAYVFLFIEALADAGVKLGLPREQARKLAAQTVLGAAKLLLESGEHPAELRDNVTSPGGTTIAALR 239

                        250       260
                 ....*....|....*....|....*...
gi 58865554  247 ALEQGGFRAAAMSAVEAATCRAKELSKK 274
Cdd:PRK11880 240 VLEEKGLRAAVIEAVQAAAKRSKELGKE 267
proC TIGR00112
pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline ...
 27-270 3.15e-72

pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline biosynthesis. Among the four paralogs in Bacillus subtilis (proG, proH, proI, and comER), ComER is the most divergent and does not prevent proline auxotrophy from mutation of the other three. It is excluded from the seed and scores between the trusted and noise cutoffs. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 272911 [Multi-domain]  Cd Length: 245  Bit Score: 221.75  E-value: 3.15e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554    27 LIRAGKVEAKQVLASAP-TDKNLCHFRALGCQTTHSNHEVLQNCPLVIFATKPQVLPAVLAEVAPVVTTEHIIVSVAAGI 105
Cdd:TIGR00112   1 LLKAGALAPYDIYVINRsPEKLAALAKELGIVASSDAQEAVKEADVVFLAVKPQDLEEVLSELKSEKGKDKLLISIAAGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   106 SLSSMEELLPPKTRVLRVSPNLPCVVQEGAMVMTRGHHAGNEDAKLLQNLLEACGQCIEVPESYVDIHTGLSGSGVAFVC 185
Cdd:TIGR00112  81 TLEKLSQLLGGTRRVVRVMPNTPAKVGAGVTAIAANANVSEEDRALALALFKAVGSVVELPEALMDAVTALSGSGPAYVF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   186 TFSEALAEGAIKMGMPSDLAHRIAAQTLLGTAKMLQQEGKHPAQLRTDVLTPAGTTIHGLHALEQGGFRAAAMSAVEAAT 265
Cdd:TIGR00112 161 LFIEALADAGVKQGLPRELALELAAQTVKGAAKLLEESGEHPALLKDQVTSPGGTTIAGLAVLEEKGVRGAVIEAIEAAV 240


                  ....*
gi 58865554   266 CRAKE 270
Cdd:TIGR00112 241 RRSRE 245
PTZ00431 PTZ00431
pyrroline carboxylate reductase; Provisional
 10-254 2.50e-48

pyrroline carboxylate reductase; Provisional


Pssm-ID: 173621 [Multi-domain]  Cd Length: 260  Bit Score: 161.27  E-value: 2.50e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   10 RVGFVGAGRMAEAIAQGLIRAGKVEAKQVLASAPTDKNLChFRALgcqttHSNHEVLQNCPLVIFATKPQVLPAVLAEVA 89
Cdd:PTZ00431   5 RVGFIGLGKMGSALAYGIENSNIIGKENIYYHTPSKKNTP-FVYL-----QSNEELAKTCDIIVLAVKPDLAGKVLLEIK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   90 PVVTTEhIIVSVAAGISLSSMEELLPPKTRVLRVSPNLPCVVQEGAMVMTRGHHAGNEDAKLLQNLLEACGQCIEVPESY 169
Cdd:PTZ00431  79 PYLGSK-LLISICGGLNLKTLEEMVGVEAKIVRVMPNTPSLVGQGSLVFCANNNVDSTDKKKVIDIFSACGIIQEIKEKD 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554  170 VDIHTGLSGSGVAFVCTFSEALAEGAIKMGMPSDLAHRIAAQTLLGTAKMLQQEGKHPAQLRTDVLTPAGTTIHGLHALE 249
Cdd:PTZ00431 158 MDIATAISGCGPAYVFLFIESLIDAGVKNGLNRDVSKNLVLQTILGSVHMVKASDQPVQQLKDDVCSPGGITIVGLYTLE 237


                 ....*
gi 58865554  250 QGGFR 254
Cdd:PTZ00431 238 KHAFK 242
PRK07679 PRK07679
pyrroline-5-carboxylate reductase; Reviewed
 9-273 2.89e-44

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 181079 [Multi-domain]  Cd Length: 279  Bit Score: 151.08  E-value: 2.89e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554    9 RRVGFVGAGRMAEAIAQGLIRAGKVEAKQVLASAPTDKNLCHF--RALGCQTTHSNHEVLQNCPLVIFATKPQVLPAVLA 86
Cdd:PRK07679   4 QNISFLGAGSIAEAIIGGLLHANVVKGEQITVSNRSNETRLQElhQKYGVKGTHNKKELLTDANILFLAMKPKDVAEALI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   87 EVAPVVTTEHIIVSVAAGISLSSMEELLPPKTRVLRVSPNLPCVVQEGAMVMTRGHHAGNEDAKLLQNLLEACGQCIEVP 166
Cdd:PRK07679  84 PFKEYIHNNQLIISLLAGVSTHSIRNLLQKDVPIIRAMPNTSAAILKSATAISPSKHATAEHIQTAKALFETIGLVSVVE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554  167 ESyvDIH--TGLSGSGVAFVCTFSEALAEGAIKMGMPSDLAHRIAAQTLLGTAKMLQQEGKHPAQLRTDVLTPAGTTIHG 244
Cdd:PRK07679 164 EE--DMHavTALSGSGPAYIYYVVEAMEKAAKKIGLKEDVAKSLILQTMIGAAEMLKASEKHPSILRKEITSPGGTTEAG 241

                        250       260
                 ....*....|....*....|....*....
gi 58865554  245 LHALEQGGFRAAAMSAVEAATCRAKELSK 273
Cdd:PRK07679 242 IEVLQEHRFQQALISCITQATQRSHNLGK 270
P5CR_dimer pfam14748
Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of ...
 167-254 4.58e-37

Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of two domains, an N-terminal catalytic domain (pfam03807) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 464294 [Multi-domain]  Cd Length: 104  Bit Score: 126.74  E-value: 4.58e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   167 ESYVDIHTGLSGSGVAFVCTFSEALAEGAIKMGMPSDLAHRIAAQTLLGTAKMLQQEGKHPAQLRTDVLTPAGTTIHGLH 246
Cdd:pfam14748   1 ESLMDAVTALSGSGPAYVFLFIEALADAGVAMGLPREEARELAAQTVLGAAKLLLTSGEHPAELRDKVTSPGGTTIAGLA 80


                  ....*...
gi 58865554   247 ALEQGGFR 254
Cdd:pfam14748  81 VLEEGGFR 88
PRK07680 PRK07680
late competence protein ComER; Validated
 10-251 1.75e-23

late competence protein ComER; Validated


Pssm-ID: 181080 [Multi-domain]  Cd Length: 273  Bit Score: 96.19  E-value: 1.75e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   10 RVGFVGAGRMAEAIAQGLIRAGKVEAKQVLASAPTDKNLCHF--RALGCQTTHSNHEVLQNCPLVIFATKPQVLPAVLAE 87
Cdd:PRK07680   2 NIGFIGTGNMGTILIEAFLESGAVKPSQLTITNRTPAKAYHIkeRYPGIHVAKTIEEVISQSDLIFICVKPLDIYPLLQK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   88 VAPVVTTEHIIVSVAAGISLSSMEELLPPKtrVLRVSPNLPCVVQEGAMVMTRGHHAGNEDAKLLQNLLEACGQCIEVPE 167
Cdd:PRK07680  82 LAPHLTDEHCLVSITSPISVEQLETLVPCQ--VARIIPSITNRALSGASLFTFGSRCSEEDQQKLERLFSNISTPLVIEE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554  168 SYVDIHTGLSGSGVAFVCTFSEALAEGAIKM-GMPSDLAHRIAAQTLLGTAKMLQQEGKHPAQLRTDVLTPAGTTIHGLH 246
Cdd:PRK07680 160 DITRVSSDIVSCGPAFFSYLLQRFIDAAVEEtNISKEEATTLASEMLIGMGKLLEKGLYTLPTLQEKVCVKGGITGEGIK 239


                 ....*
gi 58865554  247 ALEQG 251
Cdd:PRK07680 240 VLEEE 244
PRK06928 PRK06928
pyrroline-5-carboxylate reductase; Reviewed
 10-244 5.51e-22

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 235888 [Multi-domain]  Cd Length: 277  Bit Score: 92.14  E-value: 5.51e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   10 RVGFVGAGRMAEAIAQGLIRAGKVEAKQVLASAPTDKNlcHFRAL-----GCQTTHSNHEVLQNCPLvIFATKP--QVLP 82
Cdd:PRK06928   3 KIGFIGYGSMADMIATKLLETEVATPEEIILYSSSKNE--HFNQLydkypTVELADNEAEIFTKCDH-SFICVPplAVLP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   83 aVLAEVAPVVTTEHIIVSVAAGISLSSMEELlPPKTRVLRVSPNLPCVVQEGAMVMTRGHHAGNEDAKLLQNLLEACGQC 162
Cdd:PRK06928  80 -LLKDCAPVLTPDRHVVSIAAGVSLDDLLEI-TPGLQVSRLIPSLTSAVGVGTSLVAHAETVNEANKSRLEETLSHFSHV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554  163 IEVPESYVDIHTGLSGSGVAFVCTFSEALAEGAIKMGMPSDL-AHRIAAQTLLGTAKMLQQEGKHPAQLRTDVLTPAGTT 241
Cdd:PRK06928 158 MTIREENMDIASNLTSSSPGFIAAIFEEFAEAAVRNSSLSDEeAFQFLNFALAGTGKLLVEEDYTFSGTIERVATKGGIT 237


                 ...
gi 58865554  242 IHG 244
Cdd:PRK06928 238 AEG 240
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
12-104 1.42e-11

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 59.55  E-value: 1.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554    12 GFVGAGRMAEAIAQGLIRAGKVEAkqVLASAPTDKNLCHF-RALGCQTTH-SNHEVLQNCPLVIFATKPQVLPAVLAEVA 89
Cdd:pfam03807   1 GFIGAGNMGEALARGLVAAGPHEV--VVANSRNPEKAEELaEEYGVGATAvDNEEAAEEADVVFLAVKPEDAPDVLSELS 78

                          90
                  ....*....|....*
gi 58865554    90 PVVtTEHIIVSVAAG 104
Cdd:pfam03807  79 DLL-KGKIVISIAAG 92
PRK06476 PRK06476
pyrroline-5-carboxylate reductase; Reviewed
 10-254 2.15e-07

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 235812 [Multi-domain]  Cd Length: 258  Bit Score: 50.79  E-value: 2.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   10 RVGFVGAGRMAEAIAQGLIRAGKVEAKQVLA--SAPTDKNLCH-FRALgcQTTHSNHEVLQNCPLVIFATKPQVLPAVLA 86
Cdd:PRK06476   2 KIGFIGTGAITEAMVTGLLTSPADVSEIIVSprNAQIAARLAErFPKV--RIAKDNQAVVDRSDVVFLAVRPQIAEEVLR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554   87 EVApvVTTEHIIVSVAAGISLSSMEELLPPKTRVLRVSPnLPCVVQEgamvmtRGHHAGNEDAKLLQNLLEACGQCIEV- 165
Cdd:PRK06476  80 ALR--FRPGQTVISVIAATDRAALLEWIGHDVKLVRAIP-LPFVAER------KGVTAIYPPDPFVAALFDALGTAVECd 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554  166 -PESYVDIHTGLSGSGVAFvcTFSEALAEGAIKMGMPSDLAHRIAAQTLLGTAKMLQQEGKHP-AQLRTDVLTPAGTTIH 243
Cdd:PRK06476 151 sEEEYDLLAAASALMATYF--GILETATGWLEEQGLKRQKARAYLAPLFASLAQDAVRSTKTDfSALSREFSTKGGLNEQ 228

                        250
                 ....*....|.
gi 58865554  244 GLHALEQGGFR 254
Cdd:PRK06476 229 VLNDFSRQGGY 239
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 10-120 2.26e-05

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 45.03  E-value: 2.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554  10 RVGFVGAGRMAEAIAQGLIRAG-KV-----EAKQV------------LASAPTDKNLchfralgcQTTHSNHEVLQNCPL 71
Cdd:COG0240   2 KIAVLGAGSWGTALAKVLARNGhEVtlwgrDPEVAeeinetrenpryLPGVKLPENL--------RATSDLEEALAGADL 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 58865554  72 VIFATKPQVLPAVLAEVAPVVTTEHIIVSVAAGISLSS-------MEELLPPKTRV 120
Cdd:COG0240  74 VLLAVPSQALREVLEQLAPLLPPGAPVVSATKGIEPGTgllmsevIAEELPGALRI 129
COG5495 COG5495
Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains ...
 10-119 6.73e-05

Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains [General function prediction only];


Pssm-ID: 444246 [Multi-domain]  Cd Length: 286  Bit Score: 43.26  E-value: 6.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554  10 RVGFVGAGRMAEAIAQGLIRAGkVEAKQVLASapTDKNLCHFRA-LGCQTTHSNHEVLQNCPLVIFATKPQVLPAVLAEV 88
Cdd:COG5495   5 KIGIIGAGRVGTALAAALRAAG-HEVVGVYSR--SPASAERAAAlLGAVPALDLEELAAEADLVLLAVPDDAIAEVAAGL 81

                        90       100       110
                ....*....|....*....|....*....|...
gi 58865554  89 A--PVVTTEHIIVSVAAGISLssmeELLPPKTR 119
Cdd:COG5495  82 AaaGALRPGQLVVHTSGALGS----DVLAPAAR 110
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
11-92 8.90e-03

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 36.30  E-value: 8.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865554  11 VGFVGAGRMAEAIAQGLIRAG-KVeakqVLASAPTDKnLCHFRA-LGCQTTH-SNHEVLQNCPLVIFATKPQVLPAVLAE 87
Cdd:COG2085   1 IGIIGTGNIGSALARRLAAAGhEV----VIGSRDPEK-AAALAAeLGPGARAgTNAEAAAAADVVVLAVPYEAVPDVLES 75


                ....*
gi 58865554  88 VAPVV 92
Cdd:COG2085  76 LGDAL 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH