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Conserved domains on  [gi|58865908|ref|NP_001012168|]
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tubby-related protein 2 [Rattus norvegicus]

Protein Classification

tubby family protein( domain architecture ID 11070239)

tubby (TUB) family protein similar to Mus musculus tubby protein that binds to membranes containing phosphatidylinositol 4,5-bisphosphate and functions in signal transduction from heterotrimeric G protein-coupled receptors; tubby family protein plays an important role in maintenance and function of neuronal cells during post differentiation and development in mammals, and may participate in the abscisic acid (ABA) signaling pathway in plants

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tub pfam01167
Tub family;
232-481 1.34e-130

Tub family;


:

Pssm-ID: 460094  Cd Length: 251  Bit Score: 378.46  E-value: 1.34e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865908   232 PAPREHMVQCRIVRNKHGVdkGMFPSYYLYLEAEDGvavRSsplGHFLLAGRKRKRSKTSNYLISLDPKDMSRNGNNFVG 311
Cdd:pfam01167   3 PGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSPG---DG---GKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865908   312 KVRSNVLGTKFTIFDN-----GVNPERNYWIPDSARI---REELGVVCYETNVLGFRGPRKMTVILPGMDSRKQRMKVQP 383
Cdd:pfam01167  75 KLRSNFLGTKFTLYDNqppynGANPSKSRSSFGSKKVspgRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865908   384 QNDqDSILSRVQKGARHGLLLLQNKAPSWSDESGAYVLNFHGRVTRASVKNFQIVHPDEPDHLVLQFGRVAPNIFTMDFR 463
Cdd:pfam01167 155 QSE-SSLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYR 233

                         250
                  ....*....|....*...
gi 58865908   464 YPLCPLQAFAICLSSFDG 481
Cdd:pfam01167 234 YPLSAFQAFAICLSSFDT 251
Tub_N super family cl24783
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 17-136 2.15e-10

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


The actual alignment was detected with superfamily member pfam16322:

Pssm-ID: 465092  Cd Length: 196  Bit Score: 60.21  E-value: 2.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865908    17 LQENVPQAHLPSGAHSALVTMSyvGDGSGERAPLLSPRGAvytrgngpavrhlcwlPDSSDSDVEEVTMEDIPVISRPPK 96
Cdd:pfam16322  57 VQEAAPRSAKRSGAHAALGTQG--GDGKGIDGPAAFLTEE----------------PQDSGSELQILSVGDSPTSPPPDE 118

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 58865908    97 THlanrrrgwlasPGPGISEEEEVEPKDARVEDKTPSPDP 136
Cdd:pfam16322 119 EL-----------QEPGASGEEESSKQDLGDEMQKKGISS 147
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
232-481 1.34e-130

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 378.46  E-value: 1.34e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865908   232 PAPREHMVQCRIVRNKHGVdkGMFPSYYLYLEAEDGvavRSsplGHFLLAGRKRKRSKTSNYLISLDPKDMSRNGNNFVG 311
Cdd:pfam01167   3 PGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSPG---DG---GKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865908   312 KVRSNVLGTKFTIFDN-----GVNPERNYWIPDSARI---REELGVVCYETNVLGFRGPRKMTVILPGMDSRKQRMKVQP 383
Cdd:pfam01167  75 KLRSNFLGTKFTLYDNqppynGANPSKSRSSFGSKKVspgRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865908   384 QNDqDSILSRVQKGARHGLLLLQNKAPSWSDESGAYVLNFHGRVTRASVKNFQIVHPDEPDHLVLQFGRVAPNIFTMDFR 463
Cdd:pfam01167 155 QSE-SSLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYR 233

                         250
                  ....*....|....*...
gi 58865908   464 YPLCPLQAFAICLSSFDG 481
Cdd:pfam01167 234 YPLSAFQAFAICLSSFDT 251
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 17-136 2.15e-10

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


Pssm-ID: 465092  Cd Length: 196  Bit Score: 60.21  E-value: 2.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865908    17 LQENVPQAHLPSGAHSALVTMSyvGDGSGERAPLLSPRGAvytrgngpavrhlcwlPDSSDSDVEEVTMEDIPVISRPPK 96
Cdd:pfam16322  57 VQEAAPRSAKRSGAHAALGTQG--GDGKGIDGPAAFLTEE----------------PQDSGSELQILSVGDSPTSPPPDE 118

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 58865908    97 THlanrrrgwlasPGPGISEEEEVEPKDARVEDKTPSPDP 136
Cdd:pfam16322 119 EL-----------QEPGASGEEESSKQDLGDEMQKKGISS 147
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
232-481 1.34e-130

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 378.46  E-value: 1.34e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865908   232 PAPREHMVQCRIVRNKHGVdkGMFPSYYLYLEAEDGvavRSsplGHFLLAGRKRKRSKTSNYLISLDPKDMSRNGNNFVG 311
Cdd:pfam01167   3 PGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSPG---DG---GKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865908   312 KVRSNVLGTKFTIFDN-----GVNPERNYWIPDSARI---REELGVVCYETNVLGFRGPRKMTVILPGMDSRKQRMKVQP 383
Cdd:pfam01167  75 KLRSNFLGTKFTLYDNqppynGANPSKSRSSFGSKKVspgRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865908   384 QNDqDSILSRVQKGARHGLLLLQNKAPSWSDESGAYVLNFHGRVTRASVKNFQIVHPDEPDHLVLQFGRVAPNIFTMDFR 463
Cdd:pfam01167 155 QSE-SSLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYR 233

                         250
                  ....*....|....*...
gi 58865908   464 YPLCPLQAFAICLSSFDG 481
Cdd:pfam01167 234 YPLSAFQAFAICLSSFDT 251
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 17-136 2.15e-10

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


Pssm-ID: 465092  Cd Length: 196  Bit Score: 60.21  E-value: 2.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865908    17 LQENVPQAHLPSGAHSALVTMSyvGDGSGERAPLLSPRGAvytrgngpavrhlcwlPDSSDSDVEEVTMEDIPVISRPPK 96
Cdd:pfam16322  57 VQEAAPRSAKRSGAHAALGTQG--GDGKGIDGPAAFLTEE----------------PQDSGSELQILSVGDSPTSPPPDE 118

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 58865908    97 THlanrrrgwlasPGPGISEEEEVEPKDARVEDKTPSPDP 136
Cdd:pfam16322 119 EL-----------QEPGASGEEESSKQDLGDEMQKKGISS 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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