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Conserved domains on  [gi|61557121|ref|NP_001013173|]
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leucine-rich repeat protein SHOC-2 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-448 8.00e-36

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 138.91  E-value: 8.00e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 114 ILPPSVKELTQLTELYLYSNKlqslpaEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDS 193
Cdd:COG4886  87 LGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 194 LTTLYLRFNRITAVEKDVRNLPRLSTLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNEL 273
Cdd:COG4886 161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 274 LDLPDtIGNLSSLNRLGLRYNRLSAIPrSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ 353
Cdd:COG4886 241 TDLPE-LGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 354 FSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILS 433
Cdd:COG4886 319 LLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398

                       330
                ....*....|....*
gi 61557121 434 NNLLKKLPHGLGNLR 448
Cdd:COG4886 399 GVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
387-560 2.76e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 2.76e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 387 KDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLlkklphGLGNLRKLRELDLEENKLESLPNE 466
Cdd:COG4886  58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEE 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 467 IAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELALCSKLSIM 546
Cdd:COG4886 132 LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNN-QITDLPEPLGNLTNLEEL 210

                       170
                ....*....|....
gi 61557121 547 SIENCPLSHLPPQI 560
Cdd:COG4886 211 DLSGNQLTDLPEPL 224
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-448 8.00e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 138.91  E-value: 8.00e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 114 ILPPSVKELTQLTELYLYSNKlqslpaEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDS 193
Cdd:COG4886  87 LGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 194 LTTLYLRFNRITAVEKDVRNLPRLSTLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNEL 273
Cdd:COG4886 161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 274 LDLPDtIGNLSSLNRLGLRYNRLSAIPrSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ 353
Cdd:COG4886 241 TDLPE-LGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 354 FSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILS 433
Cdd:COG4886 319 LLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398

                       330
                ....*....|....*
gi 61557121 434 NNLLKKLPHGLGNLR 448
Cdd:COG4886 399 GVLLLTLALLDAVNT 413
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-483 4.26e-25

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 110.32  E-value: 4.26e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  115 LPPSVKELTQLTELYLYSNKLQ-SLPAEVGCLVNLMTLALSENSLTSlpdsldnlkklrmldlrhnklrEIPSVVYRLDS 193
Cdd:PLN00113 252 IPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSG----------------------EIPELVIQLQN 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  194 LTTLYLRFNRITA-VEKDVRNLPRLSTLSIRENKIK-QLPAEIGELCNLITLDVAHNQLE-HLPKEIGNCTQITNLDLQH 270
Cdd:PLN00113 310 LEILHLFSNNFTGkIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFS 389

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  271 NELLD-LPDTIGNLSSLNRLGLRYNRLSA-IPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFqlypV 348
Cdd:PLN00113 390 NSLEGeIPKSLGACRSLRRVRLQDNSFSGeLPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKF----F 465

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  349 GGPSQFS---TIYSLNMEHNRINK-IP--FGIFSRakvLSKLNMKDNQLTS-LPLDFGTWTSMVELNLATNQLT-KIPED 420
Cdd:PLN00113 466 GGLPDSFgskRLENLDLSRNQFSGaVPrkLGSLSE---LMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSgQIPAS 542

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 61557121  421 VSGLVSLEVLILSNNLLK-KLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQL 483
Cdd:PLN00113 543 FSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPSTGAFLAINASAVAGNIDL 607
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
387-560 2.76e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 2.76e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 387 KDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLlkklphGLGNLRKLRELDLEENKLESLPNE 466
Cdd:COG4886  58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEE 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 467 IAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELALCSKLSIM 546
Cdd:COG4886 132 LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNN-QITDLPEPLGNLTNLEEL 210

                       170
                ....*....|....
gi 61557121 547 SIENCPLSHLPPQI 560
Cdd:COG4886 211 DLSGNQLTDLPEPL 224
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 360-528 2.63e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 80.99  E-value: 2.63e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 360 LNMEHNRINKIpfGIFSRAKVLSKLNMKDNQLTSLPlDFGTWTSMVELNLATNQLTKIpEDVSGLVSLEVLILSNNLLKK 439
Cdd:cd21340   7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 440 LpHGLGNLRKLRELDLE------ENKLESLPNEIAYLKD-LQKLVLTNNQLTTLpRGIGHLTNLTHLGLGENLLTHLPE- 511
Cdd:cd21340  83 V-EGLENLTNLEELHIEnqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEEl 160

                       170
                ....*....|....*....
gi 61557121 512 --EIGTLENLEELYLNDNP 528
Cdd:cd21340 161 ldLLSSWPSLRELDLTGNP 179
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 353-562 1.30e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 83.74  E-value: 1.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  353 QFSTIYSLNMEHNRIN-KIPFGIFSRAKVLSKLNMKDNQLTSlPLDFGTWTSMVELNLATNQLT-KIPEDVSGLVSLEVL 430
Cdd:PLN00113  91 RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  431 ILSNN-LLKKLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQLT-TLPRGIGHLTNLTHLGLGENLLT 507
Cdd:PLN00113 170 DLGGNvLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLT 249

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 61557121  508 -HLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVA 562
Cdd:PLN00113 250 gPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVI 305
LRR_8 pfam13855
Leucine rich repeat;
123-181 4.83e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 4.83e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 61557121   123 TQLTELYLYSNKLQSLPAEV-GCLVNLMTLALSENSLTSL-PDSLDNLKKLRMLDLRHNKL 181
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 383-528 4.70e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.97  E-value: 4.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 383 KLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTK----IPEDVSGLVSLEVLILSNNLL-----KKLPHGLGNLR-KLRE 452
Cdd:cd00116  62 ETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPdgcgVLESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPpALEK 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 453 LDLEENKL-----ESLPNEIAYLKDLQKLVLTNNQL-----TTLPRGIGHLTNLTHLGLGENLLTH-----LPEEIGTLE 517
Cdd:cd00116 142 LVLGRNRLegascEALAKALRANRDLKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLTDegasaLAETLASLK 221

                       170
                ....*....|.
gi 61557121 518 NLEELYLNDNP 528
Cdd:cd00116 222 SLEVLNLGDNN 232
LRR_8 pfam13855
Leucine rich repeat;
426-483 1.63e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.63e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121   426 SLEVLILSNNLLKKLPHG-LGNLRKLRELDLEENKLESL-PNEIAYLKDLQKLVLTNNQL 483
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-448 8.00e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 138.91  E-value: 8.00e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 114 ILPPSVKELTQLTELYLYSNKlqslpaEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDS 193
Cdd:COG4886  87 LGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 194 LTTLYLRFNRITAVEKDVRNLPRLSTLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNEL 273
Cdd:COG4886 161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 274 LDLPDtIGNLSSLNRLGLRYNRLSAIPrSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ 353
Cdd:COG4886 241 TDLPE-LGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 354 FSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILS 433
Cdd:COG4886 319 LLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398

                       330
                ....*....|....*
gi 61557121 434 NNLLKKLPHGLGNLR 448
Cdd:COG4886 399 GVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
260-556 7.29e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 133.52  E-value: 7.29e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 260 CTQITNLDLQHNELLDLPDTIGNLSSLNRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLA 339
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 340 RNCFQLYPVGGPSQFSTIYSLNMEHNRInkipfgiFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPE 419
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 420 DVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHL 499
Cdd:COG4886 154 PLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETL 233

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 61557121 500 GLGENLLTHLPeEIGTLENLEELYLNDNpNLHSLPFELALcSKLSIMSIENCPLSHL 556
Cdd:COG4886 234 DLSNNQLTDLP-ELGNLTNLEELDLSNN-QLTDLPPLANL-TNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-498 4.87e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 122.35  E-value: 4.87e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  81 TRKKSSNAEVTKELNKCREENSMRLDLSKRSIHILPPSVKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160
Cdd:COG4886   8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 161 LPDSLDNLKKLRMLDLRHNKLreipsvVYRLDSLTTLYLRFNRITAVEKDVRNLPRLSTLSIRENKIKQLPAEIGELCNL 240
Cdd:COG4886  88 GLTDLGDLTNLTELDLSGNEE------LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 241 ITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLNRLGLRYNRLSAIPRSLAKCSALEELNLENNNIS 320
Cdd:COG4886 162 KSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLT 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 321 TLPEslLSSLVKLNSLTLARNcfQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGT 400
Cdd:COG4886 242 DLPE--LGNLTNLEELDLSNN--QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 401 WTsMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTN 480
Cdd:COG4886 318 LL-LTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTT 396

                       410
                ....*....|....*...
gi 61557121 481 NQLTTLPRGIGHLTNLTH 498
Cdd:COG4886 397 TAGVLLLTLALLDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
144-539 6.30e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 119.27  E-value: 6.30e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 144 CLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITAVEKDVRNLPRLSTLSIR 223
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 224 ENKIKQLPAEIGELCNLITLDVAHNqlehlpKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLNRLGLRYNRLSAIPRSL 303
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 304 AKCSAleelnlennnistlpesllsslvklnsltlarncfqlypvggpsqfstiyslnmehnrinkipfgifsrakvLSK 383
Cdd:COG4886 156 GNLTN------------------------------------------------------------------------LKS 163

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 384 LNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESL 463
Cdd:COG4886 164 LDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 61557121 464 PnEIAYLKDLQKLVLTNNQLTTLPrGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELAL 539
Cdd:COG4886 244 P-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
319-557 1.05e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.50  E-value: 1.05e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 319 ISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDF 398
Cdd:COG4886   7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 399 GTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVL 478
Cdd:COG4886  87 LGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDL 166

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 61557121 479 TNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELALCSKLSIMSIENCPLSHLP 557
Cdd:COG4886 167 SNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNNQLTDLP 244
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-483 4.26e-25

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 110.32  E-value: 4.26e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  115 LPPSVKELTQLTELYLYSNKLQ-SLPAEVGCLVNLMTLALSENSLTSlpdsldnlkklrmldlrhnklrEIPSVVYRLDS 193
Cdd:PLN00113 252 IPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSG----------------------EIPELVIQLQN 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  194 LTTLYLRFNRITA-VEKDVRNLPRLSTLSIRENKIK-QLPAEIGELCNLITLDVAHNQLE-HLPKEIGNCTQITNLDLQH 270
Cdd:PLN00113 310 LEILHLFSNNFTGkIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFS 389

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  271 NELLD-LPDTIGNLSSLNRLGLRYNRLSA-IPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFqlypV 348
Cdd:PLN00113 390 NSLEGeIPKSLGACRSLRRVRLQDNSFSGeLPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKF----F 465

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  349 GGPSQFS---TIYSLNMEHNRINK-IP--FGIFSRakvLSKLNMKDNQLTS-LPLDFGTWTSMVELNLATNQLT-KIPED 420
Cdd:PLN00113 466 GGLPDSFgskRLENLDLSRNQFSGaVPrkLGSLSE---LMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSgQIPAS 542

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 61557121  421 VSGLVSLEVLILSNNLLK-KLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQL 483
Cdd:PLN00113 543 FSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPSTGAFLAINASAVAGNIDL 607
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
387-560 2.76e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 2.76e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 387 KDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLlkklphGLGNLRKLRELDLEENKLESLPNE 466
Cdd:COG4886  58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEE 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 467 IAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELALCSKLSIM 546
Cdd:COG4886 132 LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNN-QITDLPEPLGNLTNLEEL 210

                       170
                ....*....|....
gi 61557121 547 SIENCPLSHLPPQI 560
Cdd:COG4886 211 DLSGNQLTDLPEPL 224
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 101-543 2.45e-22

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 101.85  E-value: 2.45e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  101 NSMR---LDLSKRSIH-ILPPSVKELTQLTELYLYSNKLQ-SLPAEVGCLV-NLMTLALSENSLTSlPDSLDNLKKLRML 174
Cdd:PLN00113  67 NSSRvvsIDLSGKNISgKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFTG-SIPRGSIPNLETL 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  175 DLRHNKLR-EIPSVVYRLDSLTTLYLRFNRITA-VEKDVRNLPRLSTLSIRENK-IKQLPAEIGELCNLITLDVAHNQLE 251
Cdd:PLN00113 146 DLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGkIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLS 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  252 -HLPKEIGNCTQITNLDLQHNELL-DLPDTIGNLSSLNRLGLRYNRLSA-IPRSLAkcsaleelnlennnistlpeslls 328
Cdd:PLN00113 226 gEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSGpIPPSIF------------------------ 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  329 SLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRIN-KIPFGIFSRAKvLSKLNMKDNQLT-SLPLDFGTWTSMVE 406
Cdd:PLN00113 282 SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPR-LQVLQLWSNKFSgEIPKNLGKHNNLTV 360

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  407 LNLATNQLT-KIPEDVSGLVSLEVLIL-SNNLLKKLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQL 483
Cdd:PLN00113 361 LDLSTNNLTgEIPEGLCSSGNLFKLILfSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNL 440

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  484 T-------------------------TLPRGIGHlTNLTHLGLGENLLTH-LPEEIGTLENLEELYLNDNPNLHSLPFEL 537
Cdd:PLN00113 441 QgrinsrkwdmpslqmlslarnkffgGLPDSFGS-KRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSGEIPDEL 519


                 ....*.
gi 61557121  538 ALCSKL 543
Cdd:PLN00113 520 SSCKKL 525
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
81-371 1.82e-20

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 95.53  E-value: 1.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121   81 TRKKSSNAEVTKELNKCREENSMRLDLSKRSIHILPPSVKEltQLTELYLYSNKLQSLPAEVGClvNLMTLALSENSLTS 160
Cdd:PRK15370 159 AKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQG--NIKTLYANSNQLTS 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  161 LPDSLDNlkKLRMLDLRHNKLREIPSvvyRLDS-LTTLYLRFNRITAVEKdvrNLPR-LSTLSIRENKIKQLPaeigelc 238
Cdd:PRK15370 235 IPATLPD--TIQEMELSINRITELPE---RLPSaLQSLDLFHNKISCLPE---NLPEeLRYLSVYDNSIRTLP------- 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  239 nlitldvahnqlEHLPkeigncTQITNLDLQHNELLDLPDTIGnlSSLNRLGLRYNRLSAIPRSLAkcSALEELNLENNN 318
Cdd:PRK15370 300 ------------AHLP------SGITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQ 357

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 61557121  319 ISTLPESLLSSlvkLNSLTLARNCFQLYPVGGPSQFSTiysLNMEHNRINKIP 371
Cdd:PRK15370 358 ITVLPETLPPT---ITTLDVSRNALTNLPENLPAALQI---MQASRNNLVRLP 404
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 89-414 5.55e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.98  E-value: 5.55e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121   89 EVTKELNKCREENSMRLDLSKRSIHIlPPSVKELTQLTELYL-YSNKLQSLPAEVGCLVNLMTLALSENSLT-SLPDSLD 166
Cdd:PLN00113 203 QIPRELGQMKSLKWIYLGYNNLSGEI-PYEIGGLTSLNHLDLvYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  167 NLKKLRMLDLRHNKLR-EIPSVVYRLDSLTTLYLRFNRITA-VEKDVRNLPRLSTLSIRENKIK-QLPAEIGELCNLITL 243
Cdd:PLN00113 282 SLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGkIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVL 361

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  244 DVAHNQLE-------------------------HLPKEIGNCTQITNLDLQHN--------------------------- 271
Cdd:PLN00113 362 DLSTNNLTgeipeglcssgnlfklilfsnslegEIPKSLGACRSLRRVRLQDNsfsgelpseftklplvyfldisnnnlq 441

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  272 -------------ELLDL---------PDTIGNlSSLNRLGLRYNRLS-AIPRSLAKCSALEELNLENNNISTLPESLLS 328
Cdd:PLN00113 442 grinsrkwdmpslQMLSLarnkffgglPDSFGS-KRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGEIPDELS 520

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  329 SLVKLnsltlarncfqlypvggpsqfstiYSLNMEHNRIN-KIPFGiFSRAKVLSKLNMKDNQLT-SLPLDFGTWTSMVE 406
Cdd:PLN00113 521 SCKKL------------------------VSLDLSHNQLSgQIPAS-FSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQ 575


                 ....*...
gi 61557121  407 LNLATNQL 414
Cdd:PLN00113 576 VNISHNHL 583
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
262-554 1.40e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 86.67  E-value: 1.40e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  262 QITNLDLQHNELLDLPDTI-GNLSSLNrlgLRYNRLSAIPrslakcsaleelnlennniSTLPESLlsslvklNSLTLAR 340
Cdd:PRK15370 200 QITTLILDNNELKSLPENLqGNIKTLY---ANSNQLTSIP-------------------ATLPDTI-------QEMELSI 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  341 NCFQLYPVGGPSqfsTIYSLNMEHNRINKIPFGIfsrAKVLSKLNMKDNQLTSLPLDFGTwtSMVELNLATNQLTKIPED 420
Cdd:PRK15370 251 NRITELPERLPS---ALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPET 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  421 VSglVSLEVLILSNNLLKKLPhglgnlrklreldleenklESLPNEiaylkdLQKLVLTNNQLTTLPRGIGhlTNLTHLG 500
Cdd:PRK15370 323 LP--PGLKTLEAGENALTSLP-------------------ASLPPE------LQVLDVSKNQITVLPETLP--PTITTLD 373

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 61557121  501 LGENLLTHLPEEI-GTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLS 554
Cdd:PRK15370 374 VSRNALTNLPENLpAALQIMQASRNNLVRLPESLPHFRGEGPQPTRIIVEYNPFS 428
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 360-528 2.63e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 80.99  E-value: 2.63e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 360 LNMEHNRINKIpfGIFSRAKVLSKLNMKDNQLTSLPlDFGTWTSMVELNLATNQLTKIpEDVSGLVSLEVLILSNNLLKK 439
Cdd:cd21340   7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 440 LpHGLGNLRKLRELDLE------ENKLESLPNEIAYLKD-LQKLVLTNNQLTTLpRGIGHLTNLTHLGLGENLLTHLPE- 511
Cdd:cd21340  83 V-EGLENLTNLEELHIEnqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEEl 160

                       170
                ....*....|....*....
gi 61557121 512 --EIGTLENLEELYLNDNP 528
Cdd:cd21340 161 ldLLSSWPSLRELDLTGNP 179
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 353-562 1.30e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 83.74  E-value: 1.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  353 QFSTIYSLNMEHNRIN-KIPFGIFSRAKVLSKLNMKDNQLTSlPLDFGTWTSMVELNLATNQLT-KIPEDVSGLVSLEVL 430
Cdd:PLN00113  91 RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  431 ILSNN-LLKKLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQLT-TLPRGIGHLTNLTHLGLGENLLT 507
Cdd:PLN00113 170 DLGGNvLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLT 249

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 61557121  508 -HLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVA 562
Cdd:PLN00113 250 gPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVI 305
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
216-448 2.60e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 82.44  E-value: 2.60e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  216 RLSTLSIRENKIKQLPAEIGelCNLITLDVAHNQLEHLPKEIGNCTQItnLDLQHNELLDLPDTIGnlSSLNRLGLRYNR 295
Cdd:PRK15370 200 QITTLILDNNELKSLPENLQ--GNIKTLYANSNQLTSIPATLPDTIQE--MELSINRITELPERLP--SALQSLDLFHNK 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  296 LSAIPRSLAKcsALEELNLENNNISTLPESLLSSLVKLNsltLARNCFQLYPVGGPSQFSTiysLNMEHNRINKIPFGIF 375
Cdd:PRK15370 274 ISCLPENLPE--ELRYLSVYDNSIRTLPAHLPSGITHLN---VQSNSLTALPETLPPGLKT---LEAGENALTSLPASLP 345

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 61557121  376 SRAKVLSklnMKDNQLTSLPLDFGtwTSMVELNLATNQLTKIPEDVSGlvSLEVLILSNNLLKKLPHGLGNLR 448
Cdd:PRK15370 346 PELQVLD---VSKNQITVLPETLP--PTITTLDVSRNALTNLPENLPA--ALQIMQASRNNLVRLPESLPHFR 411
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 123-271 8.94e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.67  E-value: 8.94e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 123 TQLTELYLYSNKLQSLPAeVGCLVNLMTLALSENSLTSLpDSLDNLKKLRMLDLRHNKLREIpSVVYRLDSLTTLYLRFN 202
Cdd:cd21340  24 KNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQ 100

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 61557121 203 RI---TAVEKDVRNL----PRLSTLSIRENKIKQLpAEIGELCNLITLDVAHNQLEHLPK---EIGNCTQITNLDLQHN 271
Cdd:cd21340 101 RLppgEKLTFDPRSLaalsNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEElldLLSSWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 122-301 1.00e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.67  E-value: 1.00e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 122 LTQLTELYLYSNKLQSLPAEVGCLvNLMTLALSENSLTSLPDsLDNLKKLRMLDLRHNKLREIPSVVyRLDSLTTLYLRF 201
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIENLE-NLVNLKKLYLGG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 202 NRITAVEkDVRNLPRLSTLSI------RENKIKQLPAEIGELCN-LITLDVAHNQLEHLpKEIGNCTQITNLDLQHNELL 274
Cdd:cd21340  78 NRISVVE-GLENLTNLEELHIenqrlpPGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQIS 155

                       170       180       190
                ....*....|....*....|....*....|
gi 61557121 275 DLPD---TIGNLSSLNRLGLRYNRLSAIPR 301
Cdd:cd21340 156 DLEElldLLSSWPSLRELDLTGNPVCKKPK 185
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
73-460 1.98e-12

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 70.19  E-value: 1.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121   73 KRPNPALGTRKKssnAEVTKELNKCREENSMRLDLSKRSIHILPPSVKelTQLTELYLYSNKLQSLPAevgCLVNLMTLA 152
Cdd:PRK15387 177 RRAAPAEESRGR---AAVVQKMRACLNNGNAVLNVGESGLTTLPDCLP--AHITTLVIPDNNLTSLPA---LPPELRTLE 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  153 LSENSLTSLPDSLDNLKKLRMLDlrhNKLREIPSVVyrlDSLTTLYLRFNRITAVEKDVrnlPRLSTLSIRENKIKQLPA 232
Cdd:PRK15387 249 VSGNQLTSLPVLPPGLLELSIFS---NPLTHLPALP---SGLCKLWIFGNQLTSLPVLP---PGLQELSVSDNQLASLPA 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  233 EIGELCNLITLDvahNQLEHLPKeignctqitnldlqhnelldLPdtignlSSLNRLGLRYNRLSAIPrslakcsaleel 312
Cdd:PRK15387 320 LPSELCKLWAYN---NQLTSLPT--------------------LP------SGLQELSVSDNQLASLP------------ 358

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  313 nlennnisTLPesllsslvklnsltlarncfqlypvggpsqfSTIYSLNMEHNRINKIPfgifSRAKVLSKLNMKDNQLT 392
Cdd:PRK15387 359 --------TLP-------------------------------SELYKLWAYNNRLTSLP----ALPSGLKELIVSGNRLT 395

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 61557121  393 SLPLdfgTWTSMVELNLATNQLTKIPEDVSGLVSLEVLilsNNLLKKLPHGLGNLRKLRELDLEENKL 460
Cdd:PRK15387 396 SLPV---LPSELKELMVSGNRLTSLPMLPSGLLSLSVY---RNQLTRLPESLIHLSSETTVNLEGNPL 457
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
217-522 1.56e-11

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 67.11  E-value: 1.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  217 LSTLSIRENKIKQLPAEIGELcnlITLDVAHNQLEHLPKEIGNctqITNLDLQHNELLDLPDTIGNLSSLNRLGLRYNRL 296
Cdd:PRK15387 224 ITTLVIPDNNLTSLPALPPEL---RTLEVSGNQLTSLPVLPPG---LLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSL 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  297 SAIPRSLAKCSaleelnlennnistLPESLLSSLVKLnsltlarncfqlypvggPSQFSTIYSLNMEHNRINKIPFGifs 376
Cdd:PRK15387 298 PVLPPGLQELS--------------VSDNQLASLPAL-----------------PSELCKLWAYNNQLTSLPTLPSG--- 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  377 rakvLSKLNMKDNQLTSLPLdfgTWTSMVELNLATNQLTKIPEDVSGLvslEVLILSNNLLKKLPHGLGnlrKLRELDLE 456
Cdd:PRK15387 344 ----LQELSVSDNQLASLPT---LPSELYKLWAYNNRLTSLPALPSGL---KELIVSGNRLTSLPVLPS---ELKELMVS 410

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 61557121  457 ENKLESLPneiAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLpeeigTLENLEEL 522
Cdd:PRK15387 411 GNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSER-----TLQALREI 468
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
379-560 3.63e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 3.63e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 379 KVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEEN 458
Cdd:COG4886   4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 459 KLESLPNEIAYLKDLQKLVLTNNQlttlprGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELA 538
Cdd:COG4886  84 LLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNN-QLTDLPEPLG 156

                       170       180
                ....*....|....*....|..
gi 61557121 539 LCSKLSIMSIENCPLSHLPPQI 560
Cdd:COG4886 157 NLTNLKSLDLSNNQLTDLPEEL 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
105-286 8.07e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.10  E-value: 8.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  105 LDLSKRSIHILPPSVKelTQLTELYLYSNKLQSLPAEVGclVNLMTLALSENSLTSLPDSLDnlKKLRMLDLRHNKLREI 184
Cdd:PRK15370 288 LSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVL 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  185 PSVVyrLDSLTTLYLRFNRITavekdvrNLPrlstlsirENkikqLPAEigelcnLITLDVAHNQL----EHLPKEIGNC 260
Cdd:PRK15370 362 PETL--PPTITTLDVSRNALT-------NLP--------EN----LPAA------LQIMQASRNNLvrlpESLPHFRGEG 414

                        170       180
                 ....*....|....*....|....*.
gi 61557121  261 TQITNLDLQHNELLDlpDTIGNLSSL 286
Cdd:PRK15370 415 PQPTRIIVEYNPFSE--RTIQNMQRL 438
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
243-528 4.49e-10

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 62.49  E-value: 4.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  243 LDVAHNQLEHLPkeigNC--TQITNLDLQHNELLDLPDTIGNLSSLNRLGLRYNRLSAIPRSLAKCSaleELNLENNNIS 320
Cdd:PRK15387 206 LNVGESGLTTLP----DClpAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELS---IFSNPLTHLP 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  321 TLPESLLSSLVKLNSLTLarncfqlYPVGGPSqfstIYSLNMEHNRINKIPfgifSRAKVLSKLNMKDNQLTSLPLdfgT 400
Cdd:PRK15387 279 ALPSGLCKLWIFGNQLTS-------LPVLPPG----LQELSVSDNQLASLP----ALPSELCKLWAYNNQLTSLPT---L 340

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  401 WTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLgnlrklRELDLEENKLESLPneiAYLKDLQKLVLTN 480
Cdd:PRK15387 341 PSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGL------KELIVSGNRLTSLP---VLPSELKELMVSG 411

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 61557121  481 NQLTTLPRgigHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNP 528
Cdd:PRK15387 412 NRLTSLPM---LPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNP 456
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
381-557 4.34e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 59.41  E-value: 4.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  381 LSKLNMKDNQLTSLPLdfgTWTSMVELNLATNQLTKIPEDVSGLVSLevLILSNNL--LKKLPHGlgnlrkLRELDLEEN 458
Cdd:PRK15387 244 LRTLEVSGNQLTSLPV---LPPGLLELSIFSNPLTHLPALPSGLCKL--WIFGNQLtsLPVLPPG------LQELSVSDN 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121  459 KLESLPneiAYLKDLQKLVLTNNQLTTLPRgigHLTNLTHLGLGENLLTHLPeeigTL-ENLEELYLNDNpNLHSLPfel 537
Cdd:PRK15387 313 QLASLP---ALPSELCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLP----TLpSELYKLWAYNN-RLTSLP--- 378

                        170       180
                 ....*....|....*....|
gi 61557121  538 ALCSKLSIMSIENCPLSHLP 557
Cdd:PRK15387 379 ALPSGLKELIVSGNRLTSLP 398
LRR_8 pfam13855
Leucine rich repeat;
123-181 4.83e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 4.83e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 61557121   123 TQLTELYLYSNKLQSLPAEV-GCLVNLMTLALSENSLTSL-PDSLDNLKKLRMLDLRHNKL 181
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
147-204 2.12e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.12e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121   147 NLMTLALSENSLTSL-PDSLDNLKKLRMLDLRHNKLREIPSVV-YRLDSLTTLYLRFNRI 204
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAfSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 383-528 4.70e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.97  E-value: 4.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 383 KLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTK----IPEDVSGLVSLEVLILSNNLL-----KKLPHGLGNLR-KLRE 452
Cdd:cd00116  62 ETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPdgcgVLESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPpALEK 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 453 LDLEENKL-----ESLPNEIAYLKDLQKLVLTNNQL-----TTLPRGIGHLTNLTHLGLGENLLTH-----LPEEIGTLE 517
Cdd:cd00116 142 LVLGRNRLegascEALAKALRANRDLKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLTDegasaLAETLASLK 221

                       170
                ....*....|.
gi 61557121 518 NLEELYLNDNP 528
Cdd:cd00116 222 SLEVLNLGDNN 232
PLN03150 PLN03150
hypothetical protein; Provisional
 229-303 8.55e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 8.55e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 61557121  229 QLPAEIGELCNLITLDVAHNQLE-HLPKEIGNCTQITNLDLQHNELL-DLPDTIGNLSSLNRLGLRYNRLSA-IPRSL 303
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGrVPAAL 510
LRR_8 pfam13855
Leucine rich repeat;
426-483 1.63e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.63e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121   426 SLEVLILSNNLLKKLPHG-LGNLRKLRELDLEENKLESL-PNEIAYLKDLQKLVLTNNQL 483
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 377-560 3.06e-06

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 50.26  E-value: 3.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121   377 RAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNL-ATNQLTKIPeDVSGLVSLEVLILSN-NLLKKLPHGLGNLRKLRELD 454
Cdd:PLN03210  609 RPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLrGSKNLKEIP-DLSMATNLETLKLSDcSSLVELPSSIQYLNKLEDLD 687

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121   455 LEE-NKLESLPNEI-------------AYLK-------DLQKLVLTNNQLTTLPRGIgHLTNLTHLGLGENLLTHLPEEI 513
Cdd:PLN03210  688 MSRcENLEILPTGInlkslyrlnlsgcSRLKsfpdistNISWLDLDETAIEEFPSNL-RLENLDELILCEMKSEKLWERV 766

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 61557121   514 GTL--------ENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCP-LSHLPPQI 560
Cdd:PLN03210  767 QPLtplmtmlsPSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENCInLETLPTGI 822
LRR_8 pfam13855
Leucine rich repeat;
473-528 1.28e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.28e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 61557121   473 LQKLVLTNNQLTTLPRGI-GHLTNLTHLGLGENLLTHL-PEEIGTLENLEELYLNDNP 528
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
402-460 1.40e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.40e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 61557121   402 TSMVELNLATNQLTKIPEDV-SGLVSLEVLILSNNLLKKL-PHGLGNLRKLRELDLEENKL 460
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 417-491 1.67e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 1.67e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 61557121  417 IPEDVSGLVSLEVLILSNNLLK-KLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQLT-TLPRGIG 491
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
PLN03150 PLN03150
hypothetical protein; Provisional
 453-527 1.91e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.50  E-value: 1.91e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 61557121  453 LDLEENKLES-LPNEIAYLKDLQKLVLTNNQLT-TLPRGIGHLTNLTHLGLGENLLT-HLPEEIGTLENLEELYLNDN 527
Cdd:PLN03150 423 LGLDNQGLRGfIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGN 500
LRR_8 pfam13855
Leucine rich repeat;
448-506 2.50e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.50e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 61557121   448 RKLRELDLEENKLESLPNEIAY-LKDLQKLVLTNNQLTTL-PRGIGHLTNLTHLGLGENLL 506
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 216-458 3.41e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 3.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 216 RLSTLSIRENKIKQLPaEIGELCNLITLDVAHNQLEHLPKeIGNCTQITNLDLQHNELLDLPDtIGNLSSLNRLGLRYNR 295
Cdd:cd21340   3 RITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 296 LSAIprslakcsaleelnlennnistlpeSLLSSLVKLNSLTLARncfQLYPVGGPSQFStiyslnmehnrinkiPFGIF 375
Cdd:cd21340  80 ISVV-------------------------EGLENLTNLEELHIEN---QRLPPGEKLTFD---------------PRSLA 116

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 376 SRAKVLSKLNMKDNQLTSLpldfgtwtsmvelnlatnqltkipEDVSGLVSLEVLILSNNLL---KKLPHGLGNLRKLRE 452
Cdd:cd21340 117 ALSNSLRVLNISGNNIDSL------------------------EPLAPLRNLEQLDASNNQIsdlEELLDLLSSWPSLRE 172


                ....*.
gi 61557121 453 LDLEEN 458
Cdd:cd21340 173 LDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
193-250 1.66e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.66e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121   193 SLTTLYLRFNRITAVEKDV-RNLPRLSTLSIRENKIKQL-PAEIGELCNLITLDVAHNQL 250
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 260-507 2.13e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 2.13e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 260 CTQITNLD---LQHNELLDLPDTIGNLSSLNRLGLRYNRLSAIPRSLAKCSaleelnlennnistlpeSLLSSLVKLNSL 336
Cdd:cd00116  24 CLQVLRLEgntLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLL-----------------QGLTKGCGLQEL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 337 TLARNCFQLYPVGGPSQFSTIYSL---NMEHNRINKIPF-----GIFSRAKVLSKLNMKDNQLTS-----LPLDFGTWTS 403
Cdd:cd00116  87 DLSDNALGPDGCGVLESLLRSSSLqelKLNNNGLGDRGLrllakGLKDLPPALEKLVLGRNRLEGasceaLAKALRANRD 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121 404 MVELNLATNQL-----TKIPEDVSGLVSLEVLILSNNLL-----KKLPHGLGNLRKLRELDLEENKLESLPneIAYLKD- 472
Cdd:cd00116 167 LKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLTDAG--AAALASa 244

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 61557121 473 -------LQKLVLTNNQLT-----TLPRGIGHLTNLTHLGLGENLLT 507
Cdd:cd00116 245 llspnisLLTLSLSCNDITddgakDLAEVLAEKESLLELDLRGNKFG 291
PLN03150 PLN03150
hypothetical protein; Provisional
 376-445 2.20e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.04  E-value: 2.20e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 61557121  376 SRAKVLSKLNMKDNQLT-SLPLDFGTWTSMVELNLATNQLT-KIPEDVSGLVSLEVLILSNNLLK-KLPHGLG 445
Cdd:PLN03150 439 SKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
PLN03150 PLN03150
hypothetical protein; Provisional
 115-188 7.03e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 7.03e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61557121  115 LPPSVKELTQLTELYLYSNKLQ-SLPAEVGCLVNLMTLALSENSLT-SLPDSLDNLKKLRMLDLRHNKLR-EIPSVV 188
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAAL 510
LRR_8 pfam13855
Leucine rich repeat;
170-227 1.51e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.51e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557121   170 KLRMLDLRHNKLREI-PSVVYRLDSLTTLYLRFNRITAVEKDV-RNLPRLSTLSIRENKI 227
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAfSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
215-273 7.14e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 7.14e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 61557121   215 PRLSTLSIRENKIKQLPAEIGE-LCNLITLDVAHNQLEHL-PKEIGNCTQITNLDLQHNEL 273
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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