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Conserved domains on  [gi|68163378|ref|NP_001020146|]
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MORN repeat-containing protein 4 [Rattus norvegicus]

Protein Classification

MORN repeat-containing protein( domain architecture ID 11468649)

membrane-occupation-and-recognition-nexus (MORN) repeat-containing protein may be involved in protein-protein interactions

PubMed:  33296386|35568981

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
5-118 1.08e-31

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 113.51  E-value: 1.08e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163378   5 KGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFSQGKFNGVGVFIRYDNMT 84
Cdd:COG4642 162 QGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDR 241

                        90       100       110
                ....*....|....*....|....*....|....
gi 68163378  85 FEGEFKNGRVDGFGLLTFPDGShglpRNEGLFEN 118
Cdd:COG4642 242 YEGEFKNGKRHGQGTMTYADGS----VYEGEWKN 271
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
5-118 1.08e-31

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 113.51  E-value: 1.08e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163378   5 KGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFSQGKFNGVGVFIRYDNMT 84
Cdd:COG4642 162 QGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDR 241

                        90       100       110
                ....*....|....*....|....*....|....
gi 68163378  85 FEGEFKNGRVDGFGLLTFPDGShglpRNEGLFEN 118
Cdd:COG4642 242 YEGEFKNGKRHGQGTMTYADGS----VYEGEWKN 271
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 6-77 2.85e-14

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 68.71  E-value: 2.85e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 68163378    6 GSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFSQGKFNGVGVF 77
Cdd:PLN03185 116 GKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGVF 187
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
16-35 1.13e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 34.62  E-value: 1.13e-03
                           10        20
                   ....*....|....*....|
gi 68163378     16 YRGEWKEGRRHGFGQLMFAD 35
Cdd:smart00698   3 YEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 16-38 1.34e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 34.31  E-value: 1.34e-03
                          10        20
                  ....*....|....*....|...
gi 68163378    16 YRGEWKEGRRHGFGQLMFADGGT 38
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
5-118 1.08e-31

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 113.51  E-value: 1.08e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163378   5 KGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFSQGKFNGVGVFIRYDNMT 84
Cdd:COG4642 162 QGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDR 241

                        90       100       110
                ....*....|....*....|....*....|....
gi 68163378  85 FEGEFKNGRVDGFGLLTFPDGShglpRNEGLFEN 118
Cdd:COG4642 242 YEGEFKNGKRHGQGTMTYADGS----VYEGEWKN 271
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
4-121 1.05e-28

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 105.81  E-value: 1.05e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163378   4 TKGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFSQGKFNGVGVFIRYDNM 83
Cdd:COG4642 138 GGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGD 217

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 68163378  84 TFEGEFKNGRVDGFGLLTFPDGShglpRNEGLFENNKL 121
Cdd:COG4642 218 RYEGEFKNGKRHGQGTLTYADGD----RYEGEFKNGKR 251
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
5-121 3.86e-25

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 96.56  E-value: 3.86e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163378   5 KGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFSQGKFNGVGVFIRYDNMT 84
Cdd:COG4642 116 GGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDV 195

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 68163378  85 FEGEFKNGRVDGFGLLTFPDGShglpRNEGLFENNKL 121
Cdd:COG4642 196 YEGEFKNGQRHGQGTYTYADGD----RYEGEFKNGKR 228
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
5-120 4.03e-15

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 69.99  E-value: 4.03e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163378   5 KGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFSQGKFNGVGVFIRYDNMT 84
Cdd:COG4642  93 GGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDR 172

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 68163378  85 FEGEFKNGRVDGFGLLTFPDGShglpRNEGLFENNK 120
Cdd:COG4642 173 YEGEFKNGKRHGQGTLTYANGD----VYEGEFKNGQ 204
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 6-77 2.85e-14

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 68.71  E-value: 2.85e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 68163378    6 GSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFSQGKFNGVGVF 77
Cdd:PLN03185 116 GKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGVF 187
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 6-116 3.17e-14

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 68.32  E-value: 3.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163378    6 GSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFSQGKFNGVGVFIRYDNMTF 85
Cdd:PLN03185  70 GTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSY 149

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 68163378   86 EGEFKNGRVDGFGLLTFPDG-------SHGLPRNEGLF 116
Cdd:PLN03185 150 EGQWLDGMMHGFGVYTWSDGgcyvgtwTRGLKDGKGVF 187
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 6-105 5.55e-14

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 67.94  E-value: 5.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163378    6 GSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFSQGKFNGVGVFIRYDNMTF 85
Cdd:PLN03185   1 GELVLSNGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTY 80

                         90       100
                 ....*....|....*....|
gi 68163378   86 EGEFKNGRVDGFGLLTFPDG 105
Cdd:PLN03185  81 KGRWRLNLKHGLGYQRYPNG 100
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 5-105 1.31e-12

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 63.70  E-value: 1.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163378    5 KGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFSQGKFNGVGVFIRYDNMT 84
Cdd:PLN03185  46 NGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNV 125

                         90       100
                 ....*....|....*....|.
gi 68163378   85 FEGEFKNGRVDGFGLLTFPDG 105
Cdd:PLN03185 126 YLGDMKGGKMSGKGTLTWVSG 146
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
6-121 6.02e-11

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 58.43  E-value: 6.02e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163378   6 GSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFSQGKFNGVGVFIRYDNMTF 85
Cdd:COG4642  71 GVTAAGGGGGGGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVY 150

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 68163378  86 EGEFKNGRVDGFGLLTFPDGShglpRNEGLFENNKL 121
Cdd:COG4642 151 EGEFKNGKPHGQGTLTYADGD----RYEGEFKNGKR 182
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 5-61 1.48e-08

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 52.14  E-value: 1.48e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 68163378    5 KGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLtFSDGSR 61
Cdd:PLN03185 138 KGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGVF-YPAGSR 193
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
16-35 1.13e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 34.62  E-value: 1.13e-03
                           10        20
                   ....*....|....*....|
gi 68163378     16 YRGEWKEGRRHGFGQLMFAD 35
Cdd:smart00698   3 YEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 16-38 1.34e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 34.31  E-value: 1.34e-03
                          10        20
                  ....*....|....*....|...
gi 68163378    16 YRGEWKEGRRHGFGQLMFADGGT 38
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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