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Conserved domains on  [gi|72086149|ref|NP_001025223|]
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NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [Rattus norvegicus]

Protein Classification

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5( domain architecture ID 7224)

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (NDUFS5) is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis

Gene Symbol:  NDUFS5
Gene Ontology:  GO:0005747|GO:0032981
PubMed:  27626371

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDUFS5-like super family cl10892
mitochondrial complex I subunit NDUFS5 and similar proteins; Ndufs5 (NADH dehydrogenase ...
 1-96 2.90e-59

mitochondrial complex I subunit NDUFS5 and similar proteins; Ndufs5 (NADH dehydrogenase [ubiquinone] iron-sulfur protein 5) is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Complex I is a 45-subunit complex that functions in the transfer of electrons from NADH to the respiratory chain. It plays a key role in cellular energy metabolism, generating a major portion of the proton motive force that drives aerobic ATP synthesis. Ndufs5 is a component of the iron-sulfur (IP) subcomplex and does not seem to be involved in catalysis.


The actual alignment was detected with superfamily member pfam10200:

Pssm-ID: 472051  Cd Length: 96  Bit Score: 176.57  E-value: 2.90e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72086149     1 MPFLDVQKRLGISLDRHFIFLSAEQPYKNAARCHAFEKEWIECAHGIGATRAKKECKIEYEDFEECFLRFKTIRRMHEIK 80
Cdd:pfam10200   1 MPFLDLQKRLGINLDRWLLIQSGEQPHKRAARCHAFEKEWIECAHGIGKTRAKKECKIEFEDFYECLLRQKTMKRLHAIR 80

                          90
                  ....*....|....*.
gi 72086149    81 KQREKLMKEGKYTPPP 96
Cdd:pfam10200  81 KQREKLIKEGKYTPPP 96
 
Name Accession Description Interval E-value
Ndufs5 pfam10200
NADH:ubiquinone oxidoreductase, NDUFS5-15kDa; This is a family of short, approximately 105 ...
 1-96 2.90e-59

NADH:ubiquinone oxidoreductase, NDUFS5-15kDa; This is a family of short, approximately 105 amino acid residue, proteins which form part of NADH:ubiquinone oxidoreductase complex I. Complex I is the first multisubunit inner membrane protein complex of the mitochondrial electron transport chain and it transfers two electrons from NADH to ubiquinone. The protein carries four highly conserved cysteine residues but these do not appear to be in a configuration which would favour metal binding so the exact function of the protein is uncertain.


Pssm-ID: 431131  Cd Length: 96  Bit Score: 176.57  E-value: 2.90e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72086149     1 MPFLDVQKRLGISLDRHFIFLSAEQPYKNAARCHAFEKEWIECAHGIGATRAKKECKIEYEDFEECFLRFKTIRRMHEIK 80
Cdd:pfam10200   1 MPFLDLQKRLGINLDRWLLIQSGEQPHKRAARCHAFEKEWIECAHGIGKTRAKKECKIEFEDFYECLLRQKTMKRLHAIR 80

                          90
                  ....*....|....*.
gi 72086149    81 KQREKLMKEGKYTPPP 96
Cdd:pfam10200  81 KQREKLIKEGKYTPPP 96
NDUFS5-like cd24141
mitochondrial complex I subunit NDUFS5 and similar proteins; Ndufs5 (NADH dehydrogenase ...
 22-87 4.29e-21

mitochondrial complex I subunit NDUFS5 and similar proteins; Ndufs5 (NADH dehydrogenase [ubiquinone] iron-sulfur protein 5) is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Complex I is a 45-subunit complex that functions in the transfer of electrons from NADH to the respiratory chain. It plays a key role in cellular energy metabolism, generating a major portion of the proton motive force that drives aerobic ATP synthesis. Ndufs5 is a component of the iron-sulfur (IP) subcomplex and does not seem to be involved in catalysis.


Pssm-ID: 467941  Cd Length: 66  Bit Score: 79.24  E-value: 4.29e-21
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 72086149  22 SAEQPYKNAARCHAFEKEWIECAHGIGatRAKKECKIEYEDFEECFLRFKTIRRMHEIKKQREKLM 87
Cdd:cd24141   3 SGFGPRGGPGRCFPFWQDFSECMSEAD--RAPKECKPEREDYLECLHHRKELARLKAIKKEREKQE 66
 
Name Accession Description Interval E-value
Ndufs5 pfam10200
NADH:ubiquinone oxidoreductase, NDUFS5-15kDa; This is a family of short, approximately 105 ...
 1-96 2.90e-59

NADH:ubiquinone oxidoreductase, NDUFS5-15kDa; This is a family of short, approximately 105 amino acid residue, proteins which form part of NADH:ubiquinone oxidoreductase complex I. Complex I is the first multisubunit inner membrane protein complex of the mitochondrial electron transport chain and it transfers two electrons from NADH to ubiquinone. The protein carries four highly conserved cysteine residues but these do not appear to be in a configuration which would favour metal binding so the exact function of the protein is uncertain.


Pssm-ID: 431131  Cd Length: 96  Bit Score: 176.57  E-value: 2.90e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72086149     1 MPFLDVQKRLGISLDRHFIFLSAEQPYKNAARCHAFEKEWIECAHGIGATRAKKECKIEYEDFEECFLRFKTIRRMHEIK 80
Cdd:pfam10200   1 MPFLDLQKRLGINLDRWLLIQSGEQPHKRAARCHAFEKEWIECAHGIGKTRAKKECKIEFEDFYECLLRQKTMKRLHAIR 80

                          90
                  ....*....|....*.
gi 72086149    81 KQREKLMKEGKYTPPP 96
Cdd:pfam10200  81 KQREKLIKEGKYTPPP 96
NDUFS5-like cd24141
mitochondrial complex I subunit NDUFS5 and similar proteins; Ndufs5 (NADH dehydrogenase ...
 22-87 4.29e-21

mitochondrial complex I subunit NDUFS5 and similar proteins; Ndufs5 (NADH dehydrogenase [ubiquinone] iron-sulfur protein 5) is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Complex I is a 45-subunit complex that functions in the transfer of electrons from NADH to the respiratory chain. It plays a key role in cellular energy metabolism, generating a major portion of the proton motive force that drives aerobic ATP synthesis. Ndufs5 is a component of the iron-sulfur (IP) subcomplex and does not seem to be involved in catalysis.


Pssm-ID: 467941  Cd Length: 66  Bit Score: 79.24  E-value: 4.29e-21
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 72086149  22 SAEQPYKNAARCHAFEKEWIECAHGIGatRAKKECKIEYEDFEECFLRFKTIRRMHEIKKQREKLM 87
Cdd:cd24141   3 SGFGPRGGPGRCFPFWQDFSECMSEAD--RAPKECKPEREDYLECLHHRKELARLKAIKKEREKQE 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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