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Conserved domains on  [gi|72255551|ref|NP_001026833|]
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regulator of microtubule dynamics protein 1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR super family cl33886
Tetratricopeptide (TPR) repeat [General function prediction only];
145-286 8.56e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


The actual alignment was detected with superfamily member COG0457:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.15  E-value: 8.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72255551 145 EALEYAKRALEKKGSSFAAHKWYAICISDVGDYEGIKvkianayvikEHFEKAIELNPKDATSIHLMGIWCYTFAEmpwy 224
Cdd:COG0457  26 EAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEAL----------ADYEQALELDPDDAEALNNLGLALQALGR---- 91

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 72255551 225 qrriaevlfanppsstYEEALKYFHRAEEVDPNfYSKNLLLLGKTYLKLNNKKLAAFWLVKA 286
Cdd:COG0457  92 ----------------YEEALEDYDKALELDPD-DAEALYNLGLALLELGRYDEAIEAYERA 136
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
145-286 8.56e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.15  E-value: 8.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72255551 145 EALEYAKRALEKKGSSFAAHKWYAICISDVGDYEGIKvkianayvikEHFEKAIELNPKDATSIHLMGIWCYTFAEmpwy 224
Cdd:COG0457  26 EAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEAL----------ADYEQALELDPDDAEALNNLGLALQALGR---- 91

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 72255551 225 qrriaevlfanppsstYEEALKYFHRAEEVDPNfYSKNLLLLGKTYLKLNNKKLAAFWLVKA 286
Cdd:COG0457  92 ----------------YEEALEDYDKALELDPD-DAEALYNLGLALLELGRYDEAIEAYERA 136
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 145-207 5.90e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 37.99  E-value: 5.90e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 72255551 145 EALEYAKRALEKKGSSFAAHKWYAICISDVGDYEgikvkiaNAYvikEHFEKAIELNPKDATS 207
Cdd:cd24142  18 LALKFLQRALELEPNNVEALELLGEILLELGDVE-------EAR---EVLLRAIELDPDGGYE 70
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
145-286 8.56e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.15  E-value: 8.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72255551 145 EALEYAKRALEKKGSSFAAHKWYAICISDVGDYEGIKvkianayvikEHFEKAIELNPKDATSIHLMGIWCYTFAEmpwy 224
Cdd:COG0457  26 EAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEAL----------ADYEQALELDPDDAEALNNLGLALQALGR---- 91

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 72255551 225 qrriaevlfanppsstYEEALKYFHRAEEVDPNfYSKNLLLLGKTYLKLNNKKLAAFWLVKA 286
Cdd:COG0457  92 ----------------YEEALEDYDKALELDPD-DAEALYNLGLALLELGRYDEAIEAYERA 136
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
145-310 3.39e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.23  E-value: 3.39e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72255551 145 EALEYAKRALEKKGSSFAAHKWYAICISDVGDYEGikvkianAyviKEHFEKAIELNPKDATSIHLMGiWCYTFAEMpwy 224
Cdd:COG0457  60 EALADYEQALELDPDDAEALNNLGLALQALGRYEE-------A---LEDYDKALELDPDDAEALYNLG-LALLELGR--- 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72255551 225 qrriaevlfanppsstYEEALKYFHRAEEVDPNfYSKNLLLLGKTYLKLNNKKLAAFWLVKAKSYPAHTEEDKQIQTEAA 304
Cdd:COG0457 126 ----------------YDEAIEAYERALELDPD-DADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAAL 188


                ....*.
gi 72255551 305 QLLTGL 310
Cdd:COG0457 189 ALAAAE 194
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 73-275 1.61e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.06  E-value: 1.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72255551  73 QAAVVHATAKVEEILEQADYLYESGETEKLYQLLTQYKESEDVELLWRLARASRDIAQLCKTSEEEKKVLLY------EA 146
Cdd:COG3914  18 LAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQalgryeEA 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72255551 147 LEYAKRALEKKGSSFAAHKWYAICISDVGDYEGikvkianayvIKEHFEKAIELNPKDATSIHLMGiwcytfaempwyqr 226
Cdd:COG3914  98 LALYRRALALNPDNAEALFNLGNLLLALGRLEE----------ALAALRRALALNPDFAEAYLNLG-------------- 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 72255551 227 riaEVLFANppsSTYEEALKYFHRAEEVDPNfYSKNLLLLGKTYLKLNN 275
Cdd:COG3914 154 ---EALRRL---GRLEEAIAALRRALELDPD-NAEALNNLGNALQDLGR 195
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 87-279 1.75e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.41  E-value: 1.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72255551  87 LEQADYLYESGETEKLYQLLTQY--KESEDVELLWRLA----------RASRDIAQLCKTSEEEKKVLLYEALEYAKRAL 154
Cdd:COG2956  12 YFKGLNYLLNGQPDKAIDLLEEAleLDPETVEAHLALGnlyrrrgeydRAIRIHQKLLERDPDRAEALLELAQDYLKAGL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72255551 155 EKKgssfaAHKWYAICISDVGDYEGIKVKIANAYVIKEHFEKAIE-------LNPKDAtsihlmgiwcytfaempWYQRR 227
Cdd:COG2956  92 LDR-----AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEvlerllkLGPENA-----------------HAYCE 149

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 72255551 228 IAEVLFANppsSTYEEALKYFHRAEEVDPNfYSKNLLLLGKTYLKLNNKKLA 279
Cdd:COG2956 150 LAELYLEQ---GDYDEAIEALEKALKLDPD-CARALLLLAELYLEQGDYEEA 197
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 80-258 8.23e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.02  E-value: 8.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72255551  80 TAKVEEILEQADYLYESGETEKLYQLLTQY--KESEDVELLWRLARASRDIAQLcktseeekkvllYEALEYAKRALEKK 157
Cdd:COG4783   1 AACAEALYALAQALLLAGDYDEAEALLEKAleLDPDNPEAFALLGEILLQLGDL------------DEAIVLLHEALELD 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72255551 158 GSSFAAHKWYAICISDVGDYEgikvkiaNAyviKEHFEKAIELNPKDatsihlmgiwcytfaemPWYQRRIAEVLFANPp 237
Cdd:COG4783  69 PDEPEARLNLGLALLKAGDYD-------EA---LALLEKALKLDPEH-----------------PEAYLRLARAYRALG- 120

                       170       180
                ....*....|....*....|.
gi 72255551 238 ssTYEEALKYFHRAEEVDPNF 258
Cdd:COG4783 121 --RPDEAIAALEKALELDPDD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 145-286 9.97e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 9.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72255551 145 EALEYAKRALEKKGSSFAAHKWYAICISDVGDYEGIKVkianayvikeHFEKAIELNPKDatsihlmgiwcytfaemPWY 224
Cdd:COG4783  22 EAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIV----------LLHEALELDPDE-----------------PEA 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 72255551 225 QRRIAEVLFAnppSSTYEEALKYFHRAEEVDPNFYSKnLLLLGKTYLKLNNKKLAAFWLVKA 286
Cdd:COG4783  75 RLNLGLALLK---AGDYDEALALLEKALKLDPEHPEA-YLRLARAYRALGRPDEAIAALEKA 132
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 145-286 1.01e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.10  E-value: 1.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72255551 145 EALEYAKRALEKKGSSFAAHKWYAICISDVGDYEgikvkiaNAyviKEHFEKAIELNPKDAtsihlmgiwcytfaempWY 224
Cdd:COG2956 128 KAIEVLERLLKLGPENAHAYCELAELYLEQGDYD-------EA---IEALEKALKLDPDCA-----------------RA 180

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 72255551 225 QRRIAEVLFANppsSTYEEALKYFHRAEEVDPNfYSKNLLLLGKTYLKLNNKKLAAFWLVKA 286
Cdd:COG2956 181 LLLLAELYLEQ---GDYEEAIAALERALEQDPD-YLPALPRLAELYEKLGDPEEALELLRKA 238
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
191-286 3.11e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.30  E-value: 3.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72255551 191 KEHFEKAIELNPKDATSIHLMGIWCYtfaempwYQRRiaevlfanppsstYEEALKyFHRAEEVDPNfYSKNLLLLGKTY 270
Cdd:COG3063  12 EEYYEKALELDPDNADALNNLGLLLL-------EQGR-------------YDEAIA-LEKALKLDPN-NAEALLNLAELL 69

                        90
                ....*....|....*.
gi 72255551 271 LKLNNKKLAAFWLVKA 286
Cdd:COG3063  70 LELGDYDEALAYLERA 85
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 145-207 5.90e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 37.99  E-value: 5.90e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 72255551 145 EALEYAKRALEKKGSSFAAHKWYAICISDVGDYEgikvkiaNAYvikEHFEKAIELNPKDATS 207
Cdd:cd24142  18 LALKFLQRALELEPNNVEALELLGEILLELGDVE-------EAR---EVLLRAIELDPDGGYE 70
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 73-282 6.16e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 38.05  E-value: 6.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72255551  73 QAAVVHATAKVEEILEQADYLYESG---ETEKLYQLLTQYKeSEDVELLWRLARASRDIAQLcktseeekkvllYEALEY 149
Cdd:COG3914 102 RRALALNPDNAEALFNLGNLLLALGrleEALAALRRALALN-PDFAEAYLNLGEALRRLGRL------------EEAIAA 168

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72255551 150 AKRALEKKGSSFAAHKWYAICISDVGDY-EGIkvkianayvikEHFEKAIELNPKDATSIHLmgiWCYTFAEMP-WYQRR 227
Cdd:COG3914 169 LRRALELDPDNAEALNNLGNALQDLGRLeEAI-----------AAYRRALELDPDNADAHSN---LLFALRQACdWEVYD 234

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 72255551 228 IAEVLFANPPSSTYEEALKYFHRAEEVDPnfysKNLLLLGKTYLKLNNKKLAAFW 282
Cdd:COG3914 235 RFEELLAALARGPSELSPFALLYLPDDDP----AELLALARAWAQLVAAAAAPEL 285
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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