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Conserved domains on  [gi|153792626|ref|NP_001092973|]
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vomeronasal 2 receptor, 52 precursor [Rattus norvegicus]

Protein Classification

vomeronasal type-2 receptor( domain architecture ID 11659857)

vomeronasal type-2 receptor is a member of the class C family of seven-transmembrane G protein-coupled receptors and most likely involved with detecting protein pheromones for social and sexual cues between members of the same species

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmC_V2R_pheromone cd15283
vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G ...
597-848 7.79e-153

vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors; This group represents vomeronasal type-2 pheromone receptors (V2Rs). Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are coexpressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are coexpressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, producing the second messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones.


:

Pssm-ID: 320410 [Multi-domain]  Cd Length: 252  Bit Score: 448.26  E-value: 7.79e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 597 TLGAVLVFVALSFSAFSAMILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSV 676
Cdd:cd15283    1 PLGIALTVLSLLGSVLTAAVLVVFIKHRDTPIVKANNSELSYLLLLSLKLCFLCSLLFIGQPSTWTCMLRQTAFGISFVL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 677 AVSTILAKTFIVVVAFKAIKPGSALKMSMVIRLSNTIVFCGSIIQVCICAVWLGTYPPFPDVDMHSEFGQIILWCNEGST 756
Cdd:cd15283   81 CISCILAKTIVVVAAFKATRPGSNIMKWFGPGQQRAIIFICTLVQVVICAIWLATSPPFPDKNMHSEHGKIILECNEGSV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 757 FAFYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLSSKGKTMVAVEILSILASSAGLLG 836
Cdd:cd15283  161 VAFYCVLGYIGLLALVSFLLAFLARKLPDNFNEAKFITFSMLVFCAVWVAFVPAYISSPGKYMVAVEIFAILASSAGLLG 240
                        250
                 ....*....|..
gi 153792626 837 CIFLPKCYVILM 848
Cdd:cd15283  241 CIFAPKCYIILL 252
Periplasmic_Binding_Protein_type1 super family cl10011
Type 1 periplasmic binding fold superfamily; Type 1 periplasmic binding fold superfamily. This ...
178-516 8.59e-100

Type 1 periplasmic binding fold superfamily; Type 1 periplasmic binding fold superfamily. This model and hierarchy represent the ligand binding domains of the LacI family of transcriptional regulators, periplasmic binding proteins of the ABC-type transport systems, the family C G-protein couples receptors (GPCRs), membrane bound guanylyl cyclases including the family of natriuretic peptide receptors (NPRs), and the N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domains of the ionotropic glutamate receptors (iGluRs). In LacI-like transcriptional regulator and the bacterial periplasmic binding proteins, the ligands are monosaccharides, including lactose, ribose, fructose, xylose, arabinose, galactose/glucose and other sugars, with a few exceptions. Periplasmic sugar binding proteins are one of the components of ABC transporters and are involved in the active transport of water-soluble ligands. The LacI family of proteins consists of transcriptional regulators related to the lac repressor. In this case, the sugar binding domain binds a sugar which changes the DNA binding activity of the repressor domain. The periplasmic binding proteins are the primary receptors for chemotaxis and transport of many sugar based solutes. The core structures of periplasmic binding proteins are classified into two types, and they differ in number and order of beta strands: type 1 has six beta strands while type 2 has five beta strands per sub-domain. These two structural folds are thought to be distantly related via a common ancestor. Notably, while the N-terminal LIVBP-like domain of iGluRs belongs to the type 1 periplasmic-binding fold protein superfamily, the glutamate-binding domain of the iGluR is structurally similar to the type 2 periplasmic-binding fold.


The actual alignment was detected with superfamily member cd06365:

Pssm-ID: 471960 [Multi-domain]  Cd Length: 464  Bit Score: 318.43  E-value: 8.59e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 178 ISYAPFDQSLGTGVQLQSPYQFPVHTTALYQGIIQLLLYFSWVWVGLVVPDDVRGELFLRDITEEMNNHGLCVAFAEKVP 257
Cdd:cd06365  128 ISYGAFDPLLSDKVQFPSFYRTVPSDTSQSLAIVQLLKHFGWTWVGLIISDDDYGEQFSQDLKKEMEKNGICVAFVEKIP 207
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 258 EFPAKDTVNRglFIERFT--LTRVIVAFGDTYSLLRFAYNIFCNTPFGNVWITTSDWDITTLSFrqNLSYTYFGGELSFS 335
Cdd:cd06365  208 TNSSLKRIIK--YINQIIksSANVIIIYGDTDSLLELLFRLWEQLVTGKVWITTSQWDISTLPF--EFYLNLFNGTLGFS 283
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 336 VHTDEILGFKDFLRSVQPRKYPQDIFIQDVWSILFECPYTYlYGIRELSQCEQNGNLSTRLLYVWDMNTSPSSYKIHDAV 415
Cdd:cd06365  284 QHSGEIPGFKEFLQSVHPSKYPEDIFLKTLWESYFNCKWPD-QNCKSLQNCCGNESLETLDVHSFDMTMSRLSYNVYNAV 362
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 416 YAIAQALHEELSFKLEENSLNKDVSKAPHLWKLHPFLQNGQLGRSTNEEAVMN-KEVSATKLDIFNYQSLQSGTKAQVKV 494
Cdd:cd06365  363 YAVAHALHEMLLCQPKTGPGNCSDRRNFQPWQLHHYLKKVQFTNPAGDEVNFDeKGDLPTKYDILNWQIFPNGTGTKVKV 442
                        330       340
                 ....*....|....*....|..
gi 153792626 495 GEFVFESYSVQNFSLNDKLITW 516
Cdd:cd06365  443 GTFDPSAPSGQQLIINDSMIEW 464
NCD3G pfam07562
Nine Cysteines Domain of family 3 GPCR; This conserved sequence contains several ...
524-577 8.05e-28

Nine Cysteines Domain of family 3 GPCR; This conserved sequence contains several highly-conserved Cys residues that are predicted to form disulphide bridges. It is predicted to lie outside the cell membrane, tethered to the pfam00003 in several receptor proteins.


:

Pssm-ID: 462210  Cd Length: 53  Bit Score: 106.18  E-value: 8.05e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 153792626  524 PFSVCSQSCPLGFRKTPVEGKPFCCFDCLLCPDGEIANeTDMDQCIKCPEDQYP 577
Cdd:pfam07562   1 PSSVCSESCPPGQRKSQQGGAPVCCWDCVPCPEGEISN-TDSDTCKKCPEGQWP 53
Mt_ATP-synt_D super family cl05445
ATP synthase D chain, mitochondrial (ATP5H); This family consists of several ATP synthase D ...
81-171 1.44e-04

ATP synthase D chain, mitochondrial (ATP5H); This family consists of several ATP synthase D chain, mitochondrial (ATP5H) proteins. Subunit d has no extensive hydrophobic sequences, and is not apparently related to any subunit described in the simpler ATP synthases in bacteria and chloroplasts.


The actual alignment was detected with superfamily member pfam05873:

Pssm-ID: 461764 [Multi-domain]  Cd Length: 154  Bit Score: 42.99  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626   81 PNSPTKINMDYpntpEKQDLVSKSylimMLEDFKKD--------VENSLREQVEAYREESQKCLKEFQENTIKQLKELKM 152
Cdd:pfam05873  44 PEEPPKIDWAY----YKKNVAKPG----LVDDFEKKyealkipyPEDTYTSEVDAQEKEVVKEIKEFIEESNKRIAEYEK 115
                          90       100       110
                  ....*....|....*....|....*....|...
gi 153792626  153 EIEAIKK----EHM----------ETTLDIENQ 171
Cdd:pfam05873 116 ELEKLKNllpfEQMtmedfceafpELALDPINK 148
 
Name Accession Description Interval E-value
7tmC_V2R_pheromone cd15283
vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G ...
597-848 7.79e-153

vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors; This group represents vomeronasal type-2 pheromone receptors (V2Rs). Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are coexpressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are coexpressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, producing the second messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones.


Pssm-ID: 320410 [Multi-domain]  Cd Length: 252  Bit Score: 448.26  E-value: 7.79e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 597 TLGAVLVFVALSFSAFSAMILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSV 676
Cdd:cd15283    1 PLGIALTVLSLLGSVLTAAVLVVFIKHRDTPIVKANNSELSYLLLLSLKLCFLCSLLFIGQPSTWTCMLRQTAFGISFVL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 677 AVSTILAKTFIVVVAFKAIKPGSALKMSMVIRLSNTIVFCGSIIQVCICAVWLGTYPPFPDVDMHSEFGQIILWCNEGST 756
Cdd:cd15283   81 CISCILAKTIVVVAAFKATRPGSNIMKWFGPGQQRAIIFICTLVQVVICAIWLATSPPFPDKNMHSEHGKIILECNEGSV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 757 FAFYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLSSKGKTMVAVEILSILASSAGLLG 836
Cdd:cd15283  161 VAFYCVLGYIGLLALVSFLLAFLARKLPDNFNEAKFITFSMLVFCAVWVAFVPAYISSPGKYMVAVEIFAILASSAGLLG 240
                        250
                 ....*....|..
gi 153792626 837 CIFLPKCYVILM 848
Cdd:cd15283  241 CIFAPKCYIILL 252
PBP1_pheromone_receptor cd06365
Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within ...
178-516 8.59e-100

Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptor, the GABAb receptor, the calcium-sensing receptor (CaSR), the T1R taste receptor, and a small group of uncharacterized orphan receptors.


Pssm-ID: 380588 [Multi-domain]  Cd Length: 464  Bit Score: 318.43  E-value: 8.59e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 178 ISYAPFDQSLGTGVQLQSPYQFPVHTTALYQGIIQLLLYFSWVWVGLVVPDDVRGELFLRDITEEMNNHGLCVAFAEKVP 257
Cdd:cd06365  128 ISYGAFDPLLSDKVQFPSFYRTVPSDTSQSLAIVQLLKHFGWTWVGLIISDDDYGEQFSQDLKKEMEKNGICVAFVEKIP 207
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 258 EFPAKDTVNRglFIERFT--LTRVIVAFGDTYSLLRFAYNIFCNTPFGNVWITTSDWDITTLSFrqNLSYTYFGGELSFS 335
Cdd:cd06365  208 TNSSLKRIIK--YINQIIksSANVIIIYGDTDSLLELLFRLWEQLVTGKVWITTSQWDISTLPF--EFYLNLFNGTLGFS 283
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 336 VHTDEILGFKDFLRSVQPRKYPQDIFIQDVWSILFECPYTYlYGIRELSQCEQNGNLSTRLLYVWDMNTSPSSYKIHDAV 415
Cdd:cd06365  284 QHSGEIPGFKEFLQSVHPSKYPEDIFLKTLWESYFNCKWPD-QNCKSLQNCCGNESLETLDVHSFDMTMSRLSYNVYNAV 362
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 416 YAIAQALHEELSFKLEENSLNKDVSKAPHLWKLHPFLQNGQLGRSTNEEAVMN-KEVSATKLDIFNYQSLQSGTKAQVKV 494
Cdd:cd06365  363 YAVAHALHEMLLCQPKTGPGNCSDRRNFQPWQLHHYLKKVQFTNPAGDEVNFDeKGDLPTKYDILNWQIFPNGTGTKVKV 442
                        330       340
                 ....*....|....*....|..
gi 153792626 495 GEFVFESYSVQNFSLNDKLITW 516
Cdd:cd06365  443 GTFDPSAPSGQQLIINDSMIEW 464
7tm_3 pfam00003
7 transmembrane sweet-taste receptor of 3 GCPR; This is a domain of seven transmembrane ...
592-842 1.24e-79

7 transmembrane sweet-taste receptor of 3 GCPR; This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.


Pssm-ID: 459626 [Multi-domain]  Cd Length: 247  Bit Score: 257.20  E-value: 1.24e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626  592 LSHEDTLGAVLVFVALSFSAFSAMILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPkTVTCVLRQVIFG 671
Cdd:pfam00003   1 LDLSAPWGIVLEALAALGILLTLVLLVVFLLHRKTPIVKASNRSLSFLLLLGLLLLFLLAFLFIGKP-TVTCALRRFLFG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626  672 VVFSVAVSTILAKTFIVVVAFKAIKPGSALKMSMVIrlsntiVFCGSIIQVCICAVWLGTyPPFPDVDMHSEfGQIILWC 751
Cdd:pfam00003  80 VGFTLCFSCLLAKTFRLVLIFRRRKPGPRGWQLLLL------ALGLLLVQVIILTEWLID-PPFPEKDNLSE-GKIILEC 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626  752 NEGSTFAF-YCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLS-SKGKTM---VAVEILS 826
Cdd:pfam00003 152 EGSTSIAFlDFVLAYVGLLLLAGFLLAFKTRKLPDNFNEAKFITFSMLLSVLIWVAFIPMYLYgNKGKGTwdpVALAIFA 231
                         250
                  ....*....|....*.
gi 153792626  827 ILASSAGLLGCIFLPK 842
Cdd:pfam00003 232 ILASGWVLLGLYFIPK 247
NCD3G pfam07562
Nine Cysteines Domain of family 3 GPCR; This conserved sequence contains several ...
524-577 8.05e-28

Nine Cysteines Domain of family 3 GPCR; This conserved sequence contains several highly-conserved Cys residues that are predicted to form disulphide bridges. It is predicted to lie outside the cell membrane, tethered to the pfam00003 in several receptor proteins.


Pssm-ID: 462210  Cd Length: 53  Bit Score: 106.18  E-value: 8.05e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 153792626  524 PFSVCSQSCPLGFRKTPVEGKPFCCFDCLLCPDGEIANeTDMDQCIKCPEDQYP 577
Cdd:pfam07562   1 PSSVCSESCPPGQRKSQQGGAPVCCWDCVPCPEGEISN-TDSDTCKKCPEGQWP 53
ANF_receptor pfam01094
Receptor family ligand binding region; This family includes extracellular ligand binding ...
178-424 4.23e-10

Receptor family ligand binding region; This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.


Pssm-ID: 460062 [Multi-domain]  Cd Length: 347  Bit Score: 62.40  E-value: 4.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626  178 ISYAPFDQSLGTGVQlqSPYQFPVHTTALYQG--IIQLLLYFSWVWVGLVVPDDVRGELFLRDITEEMNNHGLCVAFAEK 255
Cdd:pfam01094  78 ISYGSTSPALSDLNR--YPTFLRTTPSDTSQAdaIVDILKHFGWKRVALIYSDDDYGESGLQALEDALRERGIRVAYKAV 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626  256 VPEFPAKDTVNRGLFIERFTLTRVIVAF---GDTYSLLRFAYNIfcN-TPFGNVWITTsDWDITTLSFRQNLSYTYFGGE 331
Cdd:pfam01094 156 IPPAQDDDEIARKLLKEVKSRARVIVVCcssETARRLLKAAREL--GmMGEGYVWIAT-DGLTTSLVILNPSTLEAAGGV 232
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626  332 LSFSVHTDEILGFKDFLRsvqprkypqdifiqdvwsilfecpytylygiRELSQCEQNGNLSTRllyvwdMNTSPSSYkI 411
Cdd:pfam01094 233 LGFRLHPPDSPEFSEFFW-------------------------------EKLSDEKELYENLGG------LPVSYGAL-A 274
                         250
                  ....*....|...
gi 153792626  412 HDAVYAIAQALHE 424
Cdd:pfam01094 275 YDAVYLLAHALHN 287
Mt_ATP-synt_D pfam05873
ATP synthase D chain, mitochondrial (ATP5H); This family consists of several ATP synthase D ...
81-171 1.44e-04

ATP synthase D chain, mitochondrial (ATP5H); This family consists of several ATP synthase D chain, mitochondrial (ATP5H) proteins. Subunit d has no extensive hydrophobic sequences, and is not apparently related to any subunit described in the simpler ATP synthases in bacteria and chloroplasts.


Pssm-ID: 461764 [Multi-domain]  Cd Length: 154  Bit Score: 42.99  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626   81 PNSPTKINMDYpntpEKQDLVSKSylimMLEDFKKD--------VENSLREQVEAYREESQKCLKEFQENTIKQLKELKM 152
Cdd:pfam05873  44 PEEPPKIDWAY----YKKNVAKPG----LVDDFEKKyealkipyPEDTYTSEVDAQEKEVVKEIKEFIEESNKRIAEYEK 115
                          90       100       110
                  ....*....|....*....|....*....|...
gi 153792626  153 EIEAIKK----EHM----------ETTLDIENQ 171
Cdd:pfam05873 116 ELEKLKNllpfEQMtmedfceafpELALDPINK 148
CBD_MYO6-like cd21759
calmodulin binding domain found in unconventional myosin-VI and similar proteins; Myosins, ...
119-171 2.28e-03

calmodulin binding domain found in unconventional myosin-VI and similar proteins; Myosins, which are actin-based motor molecules with ATPase activity, include unconventional myosins that serve in intracellular movements. Myosin-VI, also called unconventional myosin-6 (MYO6), is a reverse-direction motor protein that moves towards the minus-end of actin filaments. It is required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Myosin-VI appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. It modulates RNA polymerase II-dependent transcription. As part of the DISP (DOCK7-Induced Septin disPlacement) complex, Myosin-VI may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Myosin-VI is encoded by gene MYO6, the human homolog of the gene responsible for deafness in Snell's waltzer mice. It is mutated in autosomal dominant non-syndromic hearing loss. This family also includes Drosophila melanogaster unconventional myosin VI Jaguar (Jar; also called myosin heavy chain 95F (Mhc95F), or 95F MHC), which is a motor protein necessary for the morphogenesis of epithelial tissues during Drosophila development. Jar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. It contributes to synaptic transmission and development at the Drosophila neuromuscular junction. Together with CLIP-190 (CAP-Gly domain-containing/cytoplasmic linker protein 190), Jar may coordinate the interaction between the actin and microtubule cytoskeleton. Jar may link endocytic vesicles to microtubules and possibly be involved in transport in the early embryo and in the dynamic process of dorsal closure; its function is believed to change during the life cycle. This model corresponds to the calmodulin (CaM) binding domain (CBD), which consists of three subdomains: a unique insert (Insert 2 or Ins2), an IQ motif, and a proximal tail domain (PTD, also known as lever arm extension or LAE).


Pssm-ID: 409646 [Multi-domain]  Cd Length: 149  Bit Score: 39.41  E-value: 2.28e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 153792626 119 NSLREQVEAYREESQKcLKEFQENTIKQLKELKMEIEA----IKKEHMETTLDIENQ 171
Cdd:cd21759   75 RALEKQLKEMEEIASQ-LKKDKDKWTKQVKELKKEIDAlikkIKTNDMITRKEIDKL 130
 
Name Accession Description Interval E-value
7tmC_V2R_pheromone cd15283
vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G ...
597-848 7.79e-153

vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors; This group represents vomeronasal type-2 pheromone receptors (V2Rs). Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are coexpressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are coexpressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, producing the second messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones.


Pssm-ID: 320410 [Multi-domain]  Cd Length: 252  Bit Score: 448.26  E-value: 7.79e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 597 TLGAVLVFVALSFSAFSAMILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSV 676
Cdd:cd15283    1 PLGIALTVLSLLGSVLTAAVLVVFIKHRDTPIVKANNSELSYLLLLSLKLCFLCSLLFIGQPSTWTCMLRQTAFGISFVL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 677 AVSTILAKTFIVVVAFKAIKPGSALKMSMVIRLSNTIVFCGSIIQVCICAVWLGTYPPFPDVDMHSEFGQIILWCNEGST 756
Cdd:cd15283   81 CISCILAKTIVVVAAFKATRPGSNIMKWFGPGQQRAIIFICTLVQVVICAIWLATSPPFPDKNMHSEHGKIILECNEGSV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 757 FAFYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLSSKGKTMVAVEILSILASSAGLLG 836
Cdd:cd15283  161 VAFYCVLGYIGLLALVSFLLAFLARKLPDNFNEAKFITFSMLVFCAVWVAFVPAYISSPGKYMVAVEIFAILASSAGLLG 240
                        250
                 ....*....|..
gi 153792626 837 CIFLPKCYVILM 848
Cdd:cd15283  241 CIFAPKCYIILL 252
7tmC_V2R_AA_sensing_receptor-like cd15044
vomeronasal type-2 pheromone receptors, amino acid-sensing receptors and closely related ...
598-848 3.44e-120

vomeronasal type-2 pheromone receptors, amino acid-sensing receptors and closely related proteins; member of the class C family of seven-transmembrane G protein-coupled receptors; This group is composed of vomeronasal type-2 pheromone receptors (V2Rs), a subgroup of broad-spectrum amino-acid sensing receptors including calcium-sensing receptor (CaSR) and GPRC6A, as well as their closely related proteins. Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are co-expressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are co-expressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, producing the second messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones. CaSR is a widely expressed GPCR that is involved in sensing small changes in extracellular levels of calcium ion to maintain a constant level of the extracellular calcium via modulating the synthesis and secretion of calcium regulating hormones, such as parathyroid hormone (PTH), in order to regulate Ca(2+)transport into or out of the extracellular fluid via kidney, intestine, and/or bone. For instance, when Ca2+ is high, CaSR downregulates PTH synthesis and secretion, leading to an increase in renal Ca2+ excretion, a decrease in intestinal Ca2+ absorption, and a reduction in release of skeletal Ca2+. GRPC6A (GPCR, class C, group 6, subtype A) is a widely expressed amino acid-sensing GPCR that is most closely related to CaSR. GPRC6A is most potently activated by the basic amino acids L-arginine, L-lysine, and L-ornithine and less potently by small aliphatic amino acids. Moreover, the receptor can be either activated or modulated by divalent cations such as Ca2+. GPRC6A is expressed in the testis, but not the ovary and specifically also binds to the osteoblast-derived hormone osteocalcin (OCN), which regulates testosterone production by the testis and male fertility independently of the hypothalamic-pituitary axis. Furthermore, GPRC6A knockout studies suggest that GRPC6A is involved in regulation of bone metabolism, male reproduction, energy homeostasis, glucose metabolism, and in activation of inflammation response, as well as prostate cancer growth and progression, among others.


Pssm-ID: 320172 [Multi-domain]  Cd Length: 251  Bit Score: 363.71  E-value: 3.44e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 598 LGAVLVFVALSFSAFSAMILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVA 677
Cdd:cd15044    2 LGILLVILSILGIIFVLVVGGVFVRYRNTPIVKANNRELSYLILLSLFLCFSSSLFFIGEPQDWTCKLRQTMFGVSFTLC 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 678 VSTILAKTFIVVVAFKAIKPGSaLKMSMVIRLSNTIVFCGSIIQVCICAVWLGTYPPFPDVDMHSEFGQIILWCNEGSTF 757
Cdd:cd15044   82 ISCILTKTLKVLLAFSADKPLT-QKFLMCLYLPILIVFTCTGIQVVICTVWLIFAPPTVEVNVSPLPRVIILECNEGSIL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 758 AFYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLSSKGKTMVAVEILSILASSAGLLGC 837
Cdd:cd15044  161 AFGTMLGYIAFLAFLCFLFAFKARKLPDNYNEAKFITFGMLVFFIVWISFVPAYLSTKGKFVVAVEIIAILASSYGLLGC 240
                        250
                 ....*....|.
gi 153792626 838 IFLPKCYVILM 848
Cdd:cd15044  241 IFLPKCYVILL 251
PBP1_pheromone_receptor cd06365
Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within ...
178-516 8.59e-100

Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptor, the GABAb receptor, the calcium-sensing receptor (CaSR), the T1R taste receptor, and a small group of uncharacterized orphan receptors.


Pssm-ID: 380588 [Multi-domain]  Cd Length: 464  Bit Score: 318.43  E-value: 8.59e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 178 ISYAPFDQSLGTGVQLQSPYQFPVHTTALYQGIIQLLLYFSWVWVGLVVPDDVRGELFLRDITEEMNNHGLCVAFAEKVP 257
Cdd:cd06365  128 ISYGAFDPLLSDKVQFPSFYRTVPSDTSQSLAIVQLLKHFGWTWVGLIISDDDYGEQFSQDLKKEMEKNGICVAFVEKIP 207
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 258 EFPAKDTVNRglFIERFT--LTRVIVAFGDTYSLLRFAYNIFCNTPFGNVWITTSDWDITTLSFrqNLSYTYFGGELSFS 335
Cdd:cd06365  208 TNSSLKRIIK--YINQIIksSANVIIIYGDTDSLLELLFRLWEQLVTGKVWITTSQWDISTLPF--EFYLNLFNGTLGFS 283
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 336 VHTDEILGFKDFLRSVQPRKYPQDIFIQDVWSILFECPYTYlYGIRELSQCEQNGNLSTRLLYVWDMNTSPSSYKIHDAV 415
Cdd:cd06365  284 QHSGEIPGFKEFLQSVHPSKYPEDIFLKTLWESYFNCKWPD-QNCKSLQNCCGNESLETLDVHSFDMTMSRLSYNVYNAV 362
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 416 YAIAQALHEELSFKLEENSLNKDVSKAPHLWKLHPFLQNGQLGRSTNEEAVMN-KEVSATKLDIFNYQSLQSGTKAQVKV 494
Cdd:cd06365  363 YAVAHALHEMLLCQPKTGPGNCSDRRNFQPWQLHHYLKKVQFTNPAGDEVNFDeKGDLPTKYDILNWQIFPNGTGTKVKV 442
                        330       340
                 ....*....|....*....|..
gi 153792626 495 GEFVFESYSVQNFSLNDKLITW 516
Cdd:cd06365  443 GTFDPSAPSGQQLIINDSMIEW 464
7tm_3 pfam00003
7 transmembrane sweet-taste receptor of 3 GCPR; This is a domain of seven transmembrane ...
592-842 1.24e-79

7 transmembrane sweet-taste receptor of 3 GCPR; This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.


Pssm-ID: 459626 [Multi-domain]  Cd Length: 247  Bit Score: 257.20  E-value: 1.24e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626  592 LSHEDTLGAVLVFVALSFSAFSAMILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPkTVTCVLRQVIFG 671
Cdd:pfam00003   1 LDLSAPWGIVLEALAALGILLTLVLLVVFLLHRKTPIVKASNRSLSFLLLLGLLLLFLLAFLFIGKP-TVTCALRRFLFG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626  672 VVFSVAVSTILAKTFIVVVAFKAIKPGSALKMSMVIrlsntiVFCGSIIQVCICAVWLGTyPPFPDVDMHSEfGQIILWC 751
Cdd:pfam00003  80 VGFTLCFSCLLAKTFRLVLIFRRRKPGPRGWQLLLL------ALGLLLVQVIILTEWLID-PPFPEKDNLSE-GKIILEC 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626  752 NEGSTFAF-YCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLS-SKGKTM---VAVEILS 826
Cdd:pfam00003 152 EGSTSIAFlDFVLAYVGLLLLAGFLLAFKTRKLPDNFNEAKFITFSMLLSVLIWVAFIPMYLYgNKGKGTwdpVALAIFA 231
                         250
                  ....*....|....*.
gi 153792626  827 ILASSAGLLGCIFLPK 842
Cdd:pfam00003 232 ILASGWVLLGLYFIPK 247
7tmC_V2R-like cd15280
vomeronasal type-2 receptor-like proteins, member of the class C family of seven-transmembrane ...
598-849 3.05e-73

vomeronasal type-2 receptor-like proteins, member of the class C family of seven-transmembrane G protein-coupled receptors; This group represents vomeronasal type-2 receptor-like proteins that are closely related to the V2R family of vomeronasal GPCRs. Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are coexpressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are co-expressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, generating the secondary messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones. Human V2R1-like protein, also known as putative calcium-sensing receptor-like 1 (CASRL1), is not included here because it is a nonfunctional pseudogene.


Pssm-ID: 320407 [Multi-domain]  Cd Length: 253  Bit Score: 240.46  E-value: 3.05e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 598 LGAVLVFVALsFSAFSAMILR-LFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSV 676
Cdd:cd15280    2 LGITLIALSI-FGALVVLAVTvVYIMHRHTPLVKANDRELSFLIQMSLVITFLTSILFIGKPENWSCMARQITLALGFSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 677 AVSTILAKTFIVVVAFKAIKPGSALkMSMVIRLSNTIVFCGSIIQVCICAVWLGTYPPFPDVDMHSEFGQIILWCNEGST 756
Cdd:cd15280   81 CLSSILGKTISLFLRYRASKSETRL-DSMHPIYQKIIVLICVLIEVGICTAYLILEPPRMYKNTEVQNVKIIFECNEGSI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 757 FAFYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLSSKGKTMVAVEILSILASSAGLLG 836
Cdd:cd15280  160 EFLCSIFGFDVFLALLCFLTAFVARKLPDNFNEGKFITFGMLVFFIVWISFVPAYLSTRGKFKVAVEIFAILASSFGLLG 239
                        250
                 ....*....|...
gi 153792626 837 CIFLPKCYVILMK 849
Cdd:cd15280  240 CIFVPKCYIILLK 252
7tm_classC_mGluR-like cd13953
metabotropic glutamate receptor-like class C family of seven-transmembrane G protein-coupled ...
597-847 1.03e-67

metabotropic glutamate receptor-like class C family of seven-transmembrane G protein-coupled receptors superfamily; The class C GPCRs consist of glutamate receptors (mGluR1-8), the extracellular calcium-sensing receptors (caSR), the gamma-amino-butyric acid type B receptors (GABA-B), the vomeronasal type-2 pheromone receptors (V2R), the type 1 taste receptors (TAS1R), and the promiscuous L-alpha-amino acid receptor (GPRC6A), as well as several orphan receptors. Structurally, these receptors are typically composed of a large extracellular domain containing a Venus flytrap module which possesses the orthosteric agonist-binding site, a cysteine-rich domain (CRD) with the exception of GABA-B receptors, and the seven-transmembrane domains responsible for G protein activation. Moreover, the Venus flytrap module shows high structural homology with bacterial periplasmic amino acid-binding proteins, which serve as primary receptors in transport of a variety of soluble substrates such as amino acids and polysaccharides, among many others. The class C GPCRs exist as either homo- or heterodimers, which are essential for their function. The GABA-B1 and GABA-B2 receptors form a heterodimer via interactions between the N-terminal Venus flytrap modules and the C-terminal coiled-coiled domains. On the other hand, heterodimeric CaSRs and Tas1Rs and homodimeric mGluRs utilize Venus flytrap interactions and intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD), which can also acts as a molecular link to mediate the signal between the Venus flytrap and the 7TMs. Furthermore, members of the class C GPCRs bind a variety of endogenous ligands, ranging from amino acids, ions, to pheromones and sugar molecules, and play important roles in many physiological processes such as synaptic transmission, calcium homeostasis, and the sensation of sweet and umami tastes.


Pssm-ID: 320091 [Multi-domain]  Cd Length: 251  Bit Score: 225.19  E-value: 1.03e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 597 TLGAVLVFVALSFSAFSAMILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSV 676
Cdd:cd13953    1 PLAIVLLVLAALGLLLTIFIWVVFIRYRNTPVVKASNRELSYLLLFGILLCFLLAFLFLLPPSDVLCGLRRFLFGLSFTL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 677 AVSTILAKTFIVVVAFKAIKPGSALKMSMVIRLSNTIVFCGSIIQVCICAVWLGTYPPFPDVDMHSeFGQIILWCNEGST 756
Cdd:cd13953   81 VFSTLLVKTNRIYRIFKSGLRSSLRPKLLSNKSQLLLVLFLLLVQVAILIVWLILDPPKVEKVIDS-DNKVVELCCSTGN 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 757 FAFYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLSSKGKTMVAVEILSILASSAGLLG 836
Cdd:cd13953  160 IGLILSLVYNILLLLICTYLAFKTRKLPDNFNEARYIGFSSLLSLVIWIAFIPTYFTTSGPYRDAILSFGLLLNATVLLL 239
                        250
                 ....*....|.
gi 153792626 837 CIFLPKCYVIL 847
Cdd:cd13953  240 CLFLPKIYIIL 250
7tmC_CaSR cd15282
calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled ...
598-847 2.04e-62

calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors; CaSR is a widely expressed GPCR that is involved in sensing small changes in extracellular levels of calcium ion to maintain a constant level of the extracellular calcium via modulating the synthesis and secretion of calcium regulating hormones, such as parathyroid hormone (PTH), in order to regulate Ca(2+)transport into or out of the extracellular fluid via kidney, intestine, and/or bone. For instance, when Ca2+ is high, CaSR downregulates PTH synthesis and secretion, leading to an increase in renal Ca2+ excretion, a decrease in intestinal Ca2+ absorption, and a reduction in release of skeletal Ca2+. CaSR is coupled to both G(q/11)-dependent activation of phospholipase and, subsequently, intracellular calcium mobilization and protein kinase C activation as well as G(i/o)-dependent inhibition of adenylate cyclase leading to inhibition of cAMP formation. CaSR is closely related to GRPC6A (GPCR, class C, group 6, subtype A), which is an amino acid-sensing GPCR that is most potently activated by the basic amino acids L-arginine, L-lysine, and L-ornithine. These receptors contain a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD), and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TASR1 receptors.


Pssm-ID: 320409 [Multi-domain]  Cd Length: 252  Bit Score: 210.96  E-value: 2.04e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 598 LGAVLVFVALSFSAFSAMILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVA 677
Cdd:cd15282    2 FGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLICCFSSSLIFIGEPQDWTCRLRQPAFGISFVLC 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 678 VSTILAKTFIVVVAFKAIKPGSALKMSMVIRLSNTIVFCGSIIQVCICAVWLGTYPPFPDVDMHSEFGQIILWCNEGSTF 757
Cdd:cd15282   82 ISCILVKTNRVLLVFEAKIPTSLHRKWWGLNLQFLLVFLCTFVQIVICVIWLYTAPPSSYRNHELEDEIIFITCNEGSLM 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 758 AFYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLSSKGKTMVAVEILSILASSAGLLGC 837
Cdd:cd15282  162 ALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILASSFGLLAC 241
                        250
                 ....*....|
gi 153792626 838 IFLPKCYVIL 847
Cdd:cd15282  242 IFFNKVYIIL 251
7tmC_GPRC6A cd15281
class C of seven-transmembrane G protein-coupled receptors, subtype 6A; GRPC6A (GPCR, class C, ...
601-847 3.48e-54

class C of seven-transmembrane G protein-coupled receptors, subtype 6A; GRPC6A (GPCR, class C, group 6, subtype A) is a widely expressed amino acid-sensing GPCR that is most closely related to CaSR. GPRC6A is most potently activated by the basic amino acids L-arginine, L-lysine, and L-ornithine and less potently by small aliphatic amino acids. Moreover, the receptor can be either activated or modulated by divalent cations such as Ca2+ and Mg2+. GPRC6A is expressed in the testis, but not the ovary and specifically also binds to the osteoblast-derived hormone osteocalcin (OCN), which regulates testosterone production by the testis and male fertility independently of the hypothalamic-pituitary axis. Furthermore, GPRC6A knockout studies suggest that GRPC6A is involved in regulation of bone metabolism, male reproduction, energy homeostasis, glucose metabolism, and in activation of inflammation response, as well as prostate cancer growth and progression, among others. GPRC6A has been suggested to couple to the Gq subtype of G proteins, leading to IP3 production and intracellular calcium mobilization. GPRC6A contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD), and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320408  Cd Length: 249  Bit Score: 188.06  E-value: 3.48e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 601 VLVFVALSFSAFSAMILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVAVST 680
Cdd:cd15281    5 VLLILSALGVLLIFFISALFTKNLNTPVVKAGGGPLCYVILLSHFGSFISTVFFIGEPSDLTCKTRQTLFGISFTLCVSC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 681 ILAKTFIVVVAFkAIKPgsalKMSMVIRLSN---TIVFCGSIIQVCICAVWLGTYPPFPDVDMhSEFGQIILWCNEGSTF 757
Cdd:cd15281   85 ILVKSLKILLAF-SFDP----KLQELLKCLYkpiMIVFICTGIQVIICTVWLVFYKPFVDKNF-SLPESIILECNEGSYV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 758 AFYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLSSKGKTMVAVEILSILASSAGLLGC 837
Cdd:cd15281  159 AFGLMLGYIALLAFICFIFAFKGRKLPENYNEAKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEMIVILISNYGILSC 238
                        250
                 ....*....|
gi 153792626 838 IFLPKCYVIL 847
Cdd:cd15281  239 TFLPKCYIIL 248
7tmC_mGluRs cd15045
metabotropic glutamate receptors, member of the class C family of seven-transmembrane G ...
605-848 6.79e-42

metabotropic glutamate receptors, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group I mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to (Gi/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320173 [Multi-domain]  Cd Length: 253  Bit Score: 153.56  E-value: 6.79e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 605 VALSFSAFSAM----ILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVAVST 680
Cdd:cd15045    5 GAMAFASLGILltlfVLVVFVRYRDTPVVKASGRELSYVLLAGILLSYVMTFVLVAKPSTIVCGLQRFGLGLCFTVCYAA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 681 ILAKTFIVVVAFKAIKpGSALKMSMvIRLSNTIVFCGSII--QVCICAVWLGTYPPFPDVDmHSEFGQIILWCNEGSTFA 758
Cdd:cd15045   85 ILTKTNRIARIFRLGK-KSAKRPRF-ISPRSQLVITGLLVsvQVLVLAVWLILSPPRATHH-YPTRDKNVLVCSSALDAS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 759 FYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLSSKGKTMVAVEILSILASSAGL--LG 836
Cdd:cd15045  162 YLIGLAYPILLIILCTVYAFKTRKIPEGFNEAKYIGFTMYTTCIIWLAFVPLYFTTASNIEVRITTLSVSISLSATvqLA 241
                        250
                 ....*....|..
gi 153792626 837 CIFLPKCYVILM 848
Cdd:cd15045  242 CLFAPKVYIILF 253
7tmC_TAS1R1 cd15289
type 1 taste receptor subtype 1, member of the class C of seven-transmembrane G ...
619-847 1.31e-38

type 1 taste receptor subtype 1, member of the class C of seven-transmembrane G protein-coupled receptors; This group represents TAS1R1, which is a member of the type I taste receptor (TAS1R) family that belongs to the class C of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320416  Cd Length: 253  Bit Score: 144.49  E-value: 1.31e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 619 LFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVAVSTILAKTFIVVVAFK-AIKP 697
Cdd:cd15289   23 LFALNLTTPVVKSAGGRTCFLMLGSLAAASCSLYCHFGEPTWLACLLKQPLFSLSFTVCLSCIAVRSFQIVCIFKlASKL 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 698 GSALKMSMVIRLSNTIVFCGSIIQVCICAVWLGTYPPFPDVDMHSEFGQIILWCNEGSTFAFYCVLGYLGFLASLSLLIA 777
Cdd:cd15289  103 PRFYETWAKNHGPELFILISSAVQLLISLLWLVLNPPVPTKDYDRYPDLIVLECSQTLSVGSFLELLYNCLLSISCFVFS 182
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 778 FLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLSSKGKTMVAVEILSILASSAGLLGCIFLPKCYVIL 847
Cdd:cd15289  183 YMGKDLPANYNEAKCITFSLLIYFISWISFFTTYSIYRGKYLMAINVLAILSSLLGIFGGYFLPKVYIIL 252
7tmC_mGluRs_group2_3 cd15934
metabotropic glutamate receptors in group 2 and 3, member of the class C family of ...
619-847 9.64e-38

metabotropic glutamate receptors in group 2 and 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. The mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group I mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to (Gi/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320600  Cd Length: 252  Bit Score: 141.60  E-value: 9.64e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 619 LFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVAVSTILAKTFIVVVAFKAIKpg 698
Cdd:cd15934   23 VFIRYNDTPVVKASGRELSYVLLTGILLCYLMTFVLLAKPSVITCALRRLGLGLGFSICYAALLTKTNRISRIFNSGK-- 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 699 SALKMSMVIRLSNTIVFCGSII--QVCICAVWLGTYPPFPDVDmHSEFGQIILWCNeGSTFAFYCVLGYLGFLASLSLLI 776
Cdd:cd15934  101 RSAKRPRFISPKSQLVICLGLIsvQLIGVLVWLVVEPPGTRID-YPRRDQVVLKCK-ISDSSLLISLVYNMLLIILCTVY 178
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 153792626 777 AFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYL--SSKGKTMVAVEILSILASSAGLLGCIFLPKCYVIL 847
Cdd:cd15934  179 AFKTRKIPENFNEAKFIGFTMYTTCIIWLAFVPIYFgtSNDFKIQTTTLCVSISLSASVALGCLFAPKVYIIL 251
7tmC_TAS1R3 cd15290
type 1 taste receptor subtype 3, member of the class C of seven-transmembrane G ...
600-847 1.39e-35

type 1 taste receptor subtype 3, member of the class C of seven-transmembrane G protein-coupled receptors; This group represents TAS1R3, which is a member of the type I taste receptor (TAS1R) family that belongs to the class C of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320417 [Multi-domain]  Cd Length: 253  Bit Score: 135.57  E-value: 1.39e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 600 AVLVFVALSFS-AFSAMILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVAV 678
Cdd:cd15290    3 SLGLLLLGVLLlVLQCSVGVLFLKHRGTPLVQASGGPLSIFALLSLMGACLSLLLFLGQPSDVVCRLQQPLNALFLTVCL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 679 STILAKTF--IVVVAFkaikPGSALKMSMVIR--LSNTIVFCGSIIQVCICAVWLGTYPPFPDVDMHSE-FGQIILWCNE 753
Cdd:cd15290   83 STILSISLqiFLVTEF----PKCAASHLHWLRgpGSWLVVLICCLVQAGLCGWYVQDGPSLSEYDAKMTlFVEVFLRCPV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 754 GSTFAFYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLSSKGKTMVAVEILSILASSAG 833
Cdd:cd15290  159 EPWLGFGLMHGFNGALALISFMCTFMAQKPLKQYNLARDITFSTLIYCVTWVIFIPIYAGLQVKLRSIAQVGFILLSNLG 238
                        250
                 ....*....|....
gi 153792626 834 LLGCIFLPKCYVIL 847
Cdd:cd15290  239 LLAAYYLPKCYLLL 252
7tmC_TAS1R cd15046
type 1 taste receptors, member of the class C of seven-transmembrane G protein-coupled ...
600-848 1.84e-35

type 1 taste receptors, member of the class C of seven-transmembrane G protein-coupled receptors; This subfamily represents the type I taste receptors (TAS1Rs) that belongs to the class C family of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320174 [Multi-domain]  Cd Length: 253  Bit Score: 135.35  E-value: 1.84e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 600 AVLVFVALSFSAFSAMILRLFICYrDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVAVS 679
Cdd:cd15046    5 AVLLLAALGLLSTLAILVIFWRNF-NTPVVRSAGGPMCFLMLTLLLVAYMSVPVYFGPPKVSTCLLRQALFPLCFTVCLA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 680 TILAKTFIVVVAFK-AIKPGSALKMSMVIRLSNTIVFCGSIIQVCICAVWLGTYPPFPDVDMHSEFGQIILWCNEGSTFA 758
Cdd:cd15046   84 CIAVRSFQIVCIFKmASRFPRAYSYWVKYHGPYVSIAFITVLKMVIVVIGMLATPPSPTTDTDPDPKITIVSCNPNYRNS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 759 FYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLSSKGKTMVAVEILSILASSAGLLGCI 838
Cdd:cd15046  164 SLFNTSLDLLLSVVCFSFSYMGKDLPTNYNEAKFITFSLTFYFTSWISFCTFMLAYSGVLVTIVDLLATLLSLLAFSLGY 243
                        250
                 ....*....|
gi 153792626 839 FLPKCYVILM 848
Cdd:cd15046  244 FLPKCYIILF 253
PBP1_CaSR cd06364
ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors ...
208-516 2.15e-35

ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the CaSR calcium-sensing receptor, which is a member of the family C receptors within the G-protein coupled receptor superfamily. CaSR provides feedback control of extracellular calcium homeostasis by responding sensitively to acute fluctuations in extracellular ionized Ca2+ concentration. This ligand-binding domain has homology to the bacterial leucine-isoleucine-valine binding protein (LIVBP) and a leucine binding protein (LBP). CaSR is widely expressed in mammalian tissues and is active in tissues that are not directly involved in extracellular calcium homeostasis. Moreover, CaSR responds to aromatic, aliphatic, and polar amino acids, but not to positively charged or branched chain amino acids, which suggests that changes in plasma amino acid levels are likely to modulate whole body calcium metabolism. Additionally, the family C GPCRs includes at least two receptors with broad-spectrum amino acid-sensing properties: GPRC6A which recognizes basic and various aliphatic amino acids, its gold-fish homolog the 5.24 chemoreceptor, and a specific taste receptor (T1R) which responds to aliphatic, polar, charged, and branched amino acids, but not to aromatic amino acids.


Pssm-ID: 380587 [Multi-domain]  Cd Length: 473  Bit Score: 140.85  E-value: 2.15e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 208 QGIIQLLLYFSWVWVGLVVPDDVRGELFLRDITEEMNNHGLCVAFAEKVPEFPAKDTVNRGLFIERFTLTRVIVAF---G 284
Cdd:cd06364  158 RALAQLVKHFGWTWVGAIASDDDYGRNGIKAFLEEAEKLGICIAFSETIPRTYSQEKILRIVEVIKKSTAKVIVVFsseG 237
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 285 DTYSLLR-FAY-NIfcnTpfGNVWITTSDWdITTLSFRQNLSYTYFGGELSFSVHTDEILGFKDFLRSVQPRKYPQDIFI 362
Cdd:cd06364  238 DLEPLIKeLVRqNI---T--GRQWIASEAW-ITSSLLATPEYFPVLGGTIGFAIRRGEIPGLKEFLLRVHPSKSPSNPFV 311
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 363 QDVWSILFECPYTYLYGIRELSQ----C---EQNGNLSTRLLyvwDMNTSPSSYKIHDAVYAIAQALHeELSFKLEENSL 435
Cdd:cd06364  312 KEFWEETFNCSLSSSSKSNSSSSsrppCtgsENLENVQNPYT---DVSQLRISYNVYKAVYAIAHALH-DLLQCEPGKGP 387
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 436 NKDVSKAP----HLWKLHPFLQNGQLgRSTNEEAV---MNKEVSAtKLDIFNYQSLQSGTKAQVKVGEFVFESYSVQNFS 508
Cdd:cd06364  388 FSNGSCADikkvEPWQLLYYLKHVNF-TTKFGEEVyfdENGDPVA-SYDIINWQLSDDGTIQFVTVGYYDASAPSGEELV 465

                 ....*...
gi 153792626 509 LNDKLITW 516
Cdd:cd06364  466 INESKILW 473
7tmC_mGluR_group1 cd15285
metabotropic glutamate receptors in group 1, member of the class C family of ...
605-848 5.27e-35

metabotropic glutamate receptors in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors; Group 1 mGluRs includes mGluR1 and mGluR5, as well as their closely related invertebrate receptors. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320412  Cd Length: 250  Bit Score: 133.92  E-value: 5.27e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 605 VALSFSAF----SAMILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVAVST 680
Cdd:cd15285    5 VAMVFACVgilaTLFVTVVFIRHNDTPVVKASTRELSYIILAGILLCYASTFALLAKPSTISCYLQRILPGLSFAMIYAA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 681 ILAKTF----IVVVAFKAIKPGSALKMSmvirLSNTIVFCGSII--QVCICAVWLGTYPP-----FPDVDmhsefgQIIL 749
Cdd:cd15285   85 LVTKTNriarILAGSKKKILTRKPRFMS----ASAQVVITGILIsvEVAIIVVMLILEPPdatldYPTPK------RVRL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 750 WCNEgSTFAFYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLSSKGKTMVAVeiLSILA 829
Cdd:cd15285  155 ICNT-STLGFVVPLGFDFLLILLCTLYAFKTRNLPENFNEAKFIGFTMYTTCVIWLAFLPIYFGSDNKEITLC--FSVSL 231
                        250
                 ....*....|....*....
gi 153792626 830 SSAGLLGCIFLPKCYVILM 848
Cdd:cd15285  232 SATVALVFLFFPKVYIILF 250
7tmC_mGluR2 cd15447
metabotropic glutamate receptor 2 in group 2, member of the class C family of ...
616-847 3.89e-34

metabotropic glutamate receptor 2 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) in group 2 include mGluR 2 and 3. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320563  Cd Length: 254  Bit Score: 131.59  E-value: 3.89e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 616 ILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVAVSTILAKTFIVVVAFKAI 695
Cdd:cd15447   20 VVGVFVKNNETPVVKASGRELCYILLLGVLLCYLMTFIFIAKPSTAVCTLRRLGLGTSFAVCYSALLTKTNRIARIFSGA 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 696 KPGSalKMSMVIRLSNTIVFCGSII--QVCICAVWLGTYPPFPDVDMHSEFGQII-LWCNEGSTfAFYCVLGYLGFLASL 772
Cdd:cd15447  100 KDGA--QRPRFISPASQVAICLALIscQLLVVLIWLLVEAPGTRKETAPERRYVVtLKCNSRDS-SMLISLTYNVLLIIL 176
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 153792626 773 SLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLSSKGKTMVAVEILSILASSAG--LLGCIFLPKCYVIL 847
Cdd:cd15447  177 CTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGsvVLGCLFAPKLHIIL 253
7tmC_TAS1R2a-like cd15287
type 1 taste receptor subtype 2a and similar proteins, member of the class C of ...
599-847 1.48e-31

type 1 taste receptor subtype 2a and similar proteins, member of the class C of seven-transmembrane G protein-coupled receptors; This group includes TAS1R2a and its similar proteins found in fish. They are members of the type I taste receptor (TAS1R) family that belongs to the class C of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320414  Cd Length: 252  Bit Score: 124.03  E-value: 1.48e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 599 GAVLVFV-ALSFSAFSAMILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVA 677
Cdd:cd15287    2 VAILIMVgACVLVGLTLAVSVLFAINYNTPVVRSAGGPMCFLILGCLSLCSVSVFFYFGKPTVASCILRYFPFLLFYTVC 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 678 VSTILAKTFIVVVAFK-AIKPGSALKMSMVIRLSNTIVFCGSIIQVCICAVWLGTYPPFPDVDMHSEFGQIILWCNeGST 756
Cdd:cd15287   82 LACFVVRSFQIVCIFKiAAKFPKLHSWWVKYHGQWLLIAVAFVIQALLLITGFSFSPPKPYNDTSWYPDKIILSCD-INL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 757 FAFYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLSSKGKTMVAVEILSILASSAGLLG 836
Cdd:cd15287  161 KATSMSLVLLLSLCCLCFIFSYMGKDLPKNYNEAKAITFCLLLLILTWIIFATEYMLYRGKYIQLLNALAVLSSLYSFLL 240
                        250
                 ....*....|.
gi 153792626 837 CIFLPKCYVIL 847
Cdd:cd15287  241 WYFLPKCYIII 251
7tmC_mGluR_group2 cd15284
metabotropic glutamate receptors in group 2, member of the class C family of ...
615-847 2.06e-31

metabotropic glutamate receptors in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) in group 2 include mGluR 2 and 3. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320411  Cd Length: 254  Bit Score: 123.42  E-value: 2.06e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 615 MILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVAVSTILAKTFIVVVAFKA 694
Cdd:cd15284   19 FVIGVFIKHNNTPLVKASGRELCYILLFGVFLCYCMTFIFIAKPSPAICTLRRLGLGTSFAVCYSALLTKTNRIARIFSG 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 695 IKPGSalKMSMVIRLSNTIVFCGSII--QVCICAVWLGTYPPFPDVDMHSEFGQI-ILWCNEGSTfAFYCVLGYLGFLAS 771
Cdd:cd15284   99 VKDGA--QRPRFISPSSQVFICLALIsvQLLVVSVWLLVEAPGTRRYTLPEKRETvILKCNVRDS-SMLISLTYDVVLVI 175
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 153792626 772 LSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLSSKGKTMVAVEILSILASSAG--LLGCIFLPKCYVIL 847
Cdd:cd15284  176 LCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGfvVLGCLFAPKVHIIL 253
7tmC_mGluR4 cd15452
metabotropic glutamate receptor 4 in group 3, member of the class C family of ...
601-847 3.63e-30

metabotropic glutamate receptor 4 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The receptors in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320568 [Multi-domain]  Cd Length: 327  Bit Score: 122.01  E-value: 3.63e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 601 VLVFVALSFSAFSAMILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVAVST 680
Cdd:cd15452    5 VPLLLAVLGIIATLFVVVTFVRYNDTPIVKASGRELSYVLLTGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 681 ILAKTFIV----------VVAFKAIKPGSALkmsmvirlsnTIVFCGSIIQVCICAVWLGTYPPFPDVDMHS------EF 744
Cdd:cd15452   85 LLTKTNRIyrifeqgkrsVSAPRFISPASQL----------VITFSLISLQLLGVCVWFLVDPSHSVVDYEDqrtpdpQF 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 745 GQIILWCNEgSTFAFYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYL---SSKGKTMVA 821
Cdd:cd15452  155 ARGVLKCDI-SDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFgtsQSAEKMYIQ 233
                        250       260
                 ....*....|....*....|....*...
gi 153792626 822 VEILSILAS-SAGL-LGCIFLPKCYVIL 847
Cdd:cd15452  234 TTTLTISVSlSASVsLGMLYMPKVYVIL 261
7tmC_mGluR_group3 cd15286
metabotropic glutamate receptors in group 3, member of the class C family of ...
600-848 3.89e-30

metabotropic glutamate receptors in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320413  Cd Length: 271  Bit Score: 120.29  E-value: 3.89e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 600 AVLVFVALSFSAFSAMILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVAVS 679
Cdd:cd15286    4 AVPVALAVLGIIATLFVLVTFVRYNDTPIVRASGRELSYVLLTGIFLCYAITFLMVAEPGVGVCSLRRLFLGLGMSLSYA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 680 TILAKTFIV----------VVAFKAIKPGSALkmsmvirlsnTIVFCGSIIQVCICAVWLGTYPP--FPDVDMHS----E 743
Cdd:cd15286   84 ALLTKTNRIyrifeqgkksVTPPRFISPTSQL----------VITFSLISVQLLGVLAWFAVDPPhaLIDYEEGRtpdpE 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 744 FGQIILWCNEgSTFAFYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYL---SSKGKTMV 820
Cdd:cd15286  154 QARGVLRCDM-SDLSLICCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFgtaQSAEKLYI 232
                        250       260       270
                 ....*....|....*....|....*....|
gi 153792626 821 AVEILSI-LASSAGL-LGCIFLPKCYVILM 848
Cdd:cd15286  233 QTATLTVsMSLSASVsLGMLYMPKVYVILF 262
7tmC_mGluR6 cd15453
metabotropic glutamate receptor 6 in group 3, member of the class C family of ...
600-857 8.44e-29

metabotropic glutamate receptor 6 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The receptors in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320569 [Multi-domain]  Cd Length: 273  Bit Score: 116.67  E-value: 8.44e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 600 AVLVFVALSFsafsamILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVAVS 679
Cdd:cd15453   10 AVLGILATTT------VVITFVRFNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAFRRLFLGLGTTLSYS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 680 TILAKTFIVVVAF----------KAIKPGSALkmsmvirlsnTIVFCGSIIQVCICAVWLGTYPPFPDVDMHS------E 743
Cdd:cd15453   84 ALLTKTNRIYRIFeqgkrsvtppPFISPTSQL----------VITFSLTSLQVVGVIAWLGAQPPHSVIDYEEqrtvdpE 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 744 FGQIILWCNEgSTFAFYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYL---SSKGKTMV 820
Cdd:cd15453  154 QARGVLKCDM-SDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFgtaQSAEKIYI 232
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 153792626 821 AVEILSI-LASSAGL-LGCIFLPKCYVILMKSGDHSRKK 857
Cdd:cd15453  233 QTTTLTVsLSLSASVsLGMLYVPKTYVILFHPEQNVQKR 271
7tmC_mGluR3 cd15448
metabotropic glutamate receptor 3 in group 2, member of the class C family of ...
613-847 1.06e-28

metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) in group 2 include mGluR 2 and 3. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320564  Cd Length: 254  Bit Score: 115.82  E-value: 1.06e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 613 SAMILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVAVSTILAKTFIVVVAF 692
Cdd:cd15448   17 TCMVITVFIKHNNTPLVKASGRELCYILLFGVFLSYCMTFFFIAKPSPVICTLRRLGLGTSFAVCYSALLTKTNCIARIF 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 693 KAIKPGSalKMSMVIRLSNTIVFCGSII--QVCICAVWLGT-YPPFPDVDMHSEFGQIILWCNEGSTfAFYCVLGYLGFL 769
Cdd:cd15448   97 DGVKNGA--QRPKFISPSSQVFICLSLIlvQIVVVSVWLILeAPGTRRYTLPEKRETVILKCNVKDS-SMLISLTYDVVL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 770 ASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLSSKGKTMVAVEILSILASSAG--LLGCIFLPKCYVIL 847
Cdd:cd15448  174 VILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGfvVLGCLFAPKVHIIL 253
NCD3G pfam07562
Nine Cysteines Domain of family 3 GPCR; This conserved sequence contains several ...
524-577 8.05e-28

Nine Cysteines Domain of family 3 GPCR; This conserved sequence contains several highly-conserved Cys residues that are predicted to form disulphide bridges. It is predicted to lie outside the cell membrane, tethered to the pfam00003 in several receptor proteins.


Pssm-ID: 462210  Cd Length: 53  Bit Score: 106.18  E-value: 8.05e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 153792626  524 PFSVCSQSCPLGFRKTPVEGKPFCCFDCLLCPDGEIANeTDMDQCIKCPEDQYP 577
Cdd:pfam07562   1 PSSVCSESCPPGQRKSQQGGAPVCCWDCVPCPEGEISN-TDSDTCKKCPEGQWP 53
7tmC_mGluR8 cd15454
metabotropic glutamate receptor 8 in group 3, member of the class C family of ...
599-860 1.44e-26

metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The receptors in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320570 [Multi-domain]  Cd Length: 311  Bit Score: 111.26  E-value: 1.44e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 599 GAVLVFVALSFSAFSAMILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVAV 678
Cdd:cd15454    3 AVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYAITFLMIATPDTGICSFRRVFLGLGMCFSY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 679 STILAKTFIV----------VVAFKAIKPGSALkmsmvirlsnTIVFCGSIIQVCICAVWLGTYPPFPDVD------MHS 742
Cdd:cd15454   83 AALLTKTNRIhrifeqgkksVTAPKFISPASQL----------VITFSLISVQLLGVFVWFAVDPPHTIVDygeqrtLDP 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 743 EFGQIILWCNEgSTFAFYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYL---SSKGKTM 819
Cdd:cd15454  153 EKARGVLKCDI-SDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFgtaQSAERMY 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 153792626 820 VAVEILSI-LASSAGL-LGCIFLPKCYVILM--KSGDHSRKKFFK 860
Cdd:cd15454  232 IQTTTLTIsMSLSASVsLGMLYMPKVYIIIFhpEQNVQKRKRSFK 276
7tmC_mGluR7 cd15451
metabotropic glutamate receptor 7 in group 3, member of the class C family of ...
603-860 1.91e-26

metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The receptors in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320567  Cd Length: 307  Bit Score: 110.50  E-value: 1.91e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 603 VFVALSFSAFSAMILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVAVSTIL 682
Cdd:cd15451    7 VFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRIFLGLGMCISYAALL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 683 AKTFIVVVAFKAIKpgSALKMSMVIRLSNTIVFCGSIIQVCICAV--WLGTYPPFPDVD------MHSEFGQIILWCNEg 754
Cdd:cd15451   87 TKTNRIYRIFEQGK--KSVTAPRLISPTSQLAITSSLISVQLLGVliWFAVDPPNIIIDydeqktMNPEQARGVLKCDI- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 755 STFAFYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYL---SSKGKTMVAVEILSILA-- 829
Cdd:cd15451  164 TDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFgtaQSAEKLYIQTTTLTISMnl 243
                        250       260       270
                 ....*....|....*....|....*....|...
gi 153792626 830 SSAGLLGCIFLPKCYVILM--KSGDHSRKKFFK 860
Cdd:cd15451  244 SASVALGMLYMPKVYIIIFhpELNVQKRKRSFK 276
7tmC_mGluR5 cd15450
metabotropic glutamate receptor 5 in group 1, member of the class C family of ...
600-847 2.03e-26

metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors; Group 1 mGluRs includes mGluR1 and mGluR5, as well as their closely related invertebrate receptors. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320566  Cd Length: 250  Bit Score: 108.92  E-value: 2.03e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 600 AVLVFVALSFSAfSAMILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVAVS 679
Cdd:cd15450    5 AAVVFACLGLLA-TLFVTVIFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 680 TILAKTF----IVVVAFKAIKPGSALKMSMVIRLsnTIVFCGSIIQVCICAVWLGTYPPFPDVDMHSeFGQIILWCNEgS 755
Cdd:cd15450   84 ALVTKTNriarILAGSKKKICTKKPRFMSACAQL--VIAFILICIQLGIIVALFIMEPPDIMHDYPS-IREVYLICNT-T 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 756 TFAFYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLSSKGKTMVAVEILSILASSAglL 835
Cdd:cd15450  160 NLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVA--L 237
                        250
                 ....*....|..
gi 153792626 836 GCIFLPKCYVIL 847
Cdd:cd15450  238 GCMFVPKVYIIL 249
7tmC_mGluR1 cd15449
metabotropic glutamate receptor 1 in group 1, member of the class C family of ...
605-847 2.03e-23

metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors; Group 1 mGluRs includes mGluR1 and mGluR5, as well as their closely related invertebrate receptors. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320565  Cd Length: 250  Bit Score: 100.47  E-value: 2.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 605 VALSFSAFSAMILR----LFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVAVST 680
Cdd:cd15449    5 IAVAFSCLGILVTMfvtlIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 681 ILAKTFIVVVAFKAIKPGSALKMSMVIRLSNTIVFCGSII--QVCICAVWLGTYPPFPdVDMHSEFGQIILWCNEgSTFA 758
Cdd:cd15449   85 LVTKTNRIARILAGSKKKICTRKPRFMSAWAQVVIASILIsvQLTLVVTLIIMEPPMP-ILSYPSIKEVYLICNT-SNLG 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 759 FYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMLVFFSVWISFVPTYLSSKGKTMVAVEILSILASSAglLGCI 838
Cdd:cd15449  163 VVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVA--LGCM 240

                 ....*....
gi 153792626 839 FLPKCYVIL 847
Cdd:cd15449  241 FTPKMYIII 249
7tmC_TAS1R2 cd15288
type 1 taste receptor subtype 2, member of the class C of seven-transmembrane G ...
600-847 6.63e-22

type 1 taste receptor subtype 2, member of the class C of seven-transmembrane G protein-coupled receptors; This group represents TAS1R2, which is a member of the type I taste receptor (TAS1R) family that belongs to the class C of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320415  Cd Length: 254  Bit Score: 96.01  E-value: 6.63e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 600 AVLVFVALSFSAFSAmILRLFICYRDTPIVRANNRNLSYLLLVSLMLCFFCSLIFIGQPKTVTCVLRQVIFGVVFSVAVS 679
Cdd:cd15288    5 VVALLAALGFLSTLA-ILVIFGRHFQTPVVRSAGGRMCFLMLAPLLVAYVNVPVYVGIPTVFTCLCRQTLFPLCFTVCIS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 680 TILAKTFIVVVAFK-AIKPGSAlkMSMVIRLSNTIVFCGSII--QVCICAVWLGTYPPFPDVDMHSEFGQI-ILWCNEGS 755
Cdd:cd15288   84 CIAVRSFQIVCIFKmARRLPRA--YSYWVKYNGPYVFVALITllKVVIVVINVLAHPTAPTTRADPDDPQVmILQCNPNY 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 756 TFAFYCVLGYLGFLASLSLLIAFLARRLPDSFNEAKTITFSMlVFFSVWISFVPTYLSSKGKTMV-----AVEILSILAS 830
Cdd:cd15288  162 RLALLFNTSLDLLLSVLGFCFAYMGKELPTNYNEAKFITLCM-TFYFASSVFLCTFMSVYEGVLVtifdaLVTVINLLGI 240
                        250
                 ....*....|....*..
gi 153792626 831 SAGLLGciflPKCYVIL 847
Cdd:cd15288  241 SLGYFG----PKCYMIL 253
PBP1_mGluR cd06362
ligand binding domain of metabotropic glutamate receptors (mGluR); Ligand binding domain of ...
208-424 3.76e-15

ligand binding domain of metabotropic glutamate receptors (mGluR); Ligand binding domain of the metabotropic glutamate receptors (mGluR), which are members of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into cellular responses. mGluRs bind to glutamate and function as an excitatory neurotransmitter; they are involved in learning, memory, anxiety, and the perception of pain. Eight subtypes of mGluRs have been cloned so far, and are classified into three groups according to their sequence similarities, transduction mechanisms, and pharmacological profiles. Group I is composed of mGlu1R and mGlu5R that both stimulate PLC hydrolysis. Group II includes mGlu2R and mGlu3R, which inhibit adenylyl cyclase, as do mGlu4R, mGlu6R, mGlu7R, and mGlu8R, which form group III.


Pssm-ID: 380585 [Multi-domain]  Cd Length: 460  Bit Score: 78.87  E-value: 3.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 208 QGIIQLLLYFSWVWVGLVVPDDVRGELFLRDITEEMNNHGLCVAFAEKVPEFPAKDTVNRGLF-IERFTLTRVIVAF--- 283
Cdd:cd06362  165 KAIVDILLHFNWTYVSVVYSEGSYGEEGYKAFKKLARKAGICIAESERISQDSDEKDYDDVIQkLLQKKNARVVVLFadq 244
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 284 GDTYSLLRFAYNIFCNTPFgnVWITTSDWDITTLSFRQNLSYTYfgGELSFSVHTDEILGFKDFLRSVQPRKYPQDIFIQ 363
Cdd:cd06362  245 EDIRGLLRAAKRLGASGRF--IWLGSDGWGTNIDDLKGNEDVAL--GALTVQPYSEEVPRFDDYFKSLTPSNNTRNPWFR 320
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 153792626 364 DVWSILFECPYTYLYGIRELsQCEQNGNLSTRllYVWDMNTSPssykIHDAVYAIAQALHE 424
Cdd:cd06362  321 EFWQELFQCSFRPSRENSCN-DDKLLINKSEG--YKQESKVSF----VIDAVYAFAHALHK 374
PBP1_GPCR_family_C-like cd06350
ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory ...
178-350 4.37e-15

ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate; categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (m; Ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate and are categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). The metabotropic glutamate receptors (mGluR) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. The mGluRs are coupled to G proteins and are thus distinct from the iGluRs which internally contain ligand-gated ion channels. The mGluR structure is divided into three regions: the extracellular region, the seven-spanning transmembrane region and the cytoplasmic region. The extracellular region is further divided into the ligand-binding domain (LBD) and the cysteine-rich domain. The LBD has sequence similarity to the LIVBP, which is a bacterial periplasmic protein (PBP), as well as to the extracellular region of both iGluR and the gamma-aminobutyric acid (GABA)b receptor. iGluRs are divided into three main subtypes based on pharmacological profile: NMDA, AMPA, and kainate receptors. All family C GPCRs have a large extracellular N terminus that contain a domain with homology to bacterial periplasmic amino acid-binding proteins.


Pssm-ID: 380573  Cd Length: 350  Bit Score: 77.72  E-value: 4.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 178 ISYAPfdqslgTGVQLQSPYQFP-----VHT-TALYQGIIQLLLYFSWVWVGLVVPDDVRGELFLRDITEEMNNHGLCVA 251
Cdd:cd06350  122 ISYAS------TSPELSDKIRYPyflrtVPSdTLQAKAIADLLKHFNWNYVSTVYSDDDYGRSGIEAFEREAKERGICIA 195
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 252 FAEKVPEFPAKDTVNRGL-FIERFTLTRVIVAFGDTY---SLLRFAYnifcNTPFGN-VWITTSDWDITTLSFRQNLSyt 326
Cdd:cd06350  196 QTIVIPENSTEDEIKRIIdKLKSSPNAKVVVLFLTESdarELLKEAK----RRNLTGfTWIGSDGWGDSLVILEGYED-- 269
                        170       180
                 ....*....|....*....|....
gi 153792626 327 YFGGELSFSVHTDEILGFKDFLRS 350
Cdd:cd06350  270 VLGGAIGVVPRSKEIPGFDDYLKS 293
7tmC_GABA-B-like cd15047
gamma-aminobutyric acid type B receptor and related proteins, member of the class C family of ...
597-842 4.11e-14

gamma-aminobutyric acid type B receptor and related proteins, member of the class C family of seven-transmembrane G protein-coupled receptors; The type B receptor for gamma-aminobutyric acid, GABA-B, is activated by its endogenous ligand GABA, the principal inhibitory neurotransmitter. The functional GABA-B receptor is an obligatory heterodimer composed of two related subunits, GABA-B1, which is primarily involved in GABA ligand binding, and GABA-B2, which is responsible for both G-protein coupling and trafficking of the heterodimer to the plasma membrane. Activation of GABA-B couples to G(i/o)-type G proteins, which in turn modulate three major downstream effectors: adenylate cyclase, voltage-sensitive Ca2+ channels, and inwardly-rectifying K+ channels. Consequently, GABA-B receptor produces slow and sustained inhibitory responses by decreased neurotransmitter release via inhibition of Ca2+ channels and by postsynaptic hyperpolarization via the activation of K+ channels through the G-protein beta-gamma dimer. The GABA-B is expressed in both pre- and postsynaptic sites of glutamatergic and GABAergic neurons in the brain where it regulates synaptic activity. Thus, the GABA-B receptor agonist, baclofen, is used to treat muscle tightness and cramping caused by spasticity in multiple sclerosis patients. Moreover, GABA-B antagonists improves cognitive performance in mammals, while GABA-B agonists suppress cognitive behavior. In most of the class C family members, the extracellular Venus-flytrap domain in the N-terminus is connected to the seven-transmembrane (7TM) via a cysteine-rich domain (CRD). However, in the GABA-B receptor, the CRD is absent in both subunits and the Venus-flytrap ligand-binding domain is directly connected to the 7TM via a 10-15 amino acids linker, suggesting that GABA-B receptor may utilize a different activation mechanism. Also included in this group are orphan receptors, GPR156 and GPR158, which are closely related to the GABA-B receptor family.


Pssm-ID: 320175  Cd Length: 263  Bit Score: 73.36  E-value: 4.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 597 TLGAVLVFVALSFSAFSAMilrlficYRDTPIVRANNRNLSYLLLVSLMLCFFcSLIFIG----QPKTVTCVLRQVIFGV 672
Cdd:cd15047    8 VLSGIGILLALVFLIFNIK-------FRKNRVIKMSSPLFNNLILLGCILCYI-SVILFGlddsKPSSFLCTARPWLLSI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 673 VFSVAVSTILAKTFIVVVAFKAIKpgsalKMSMVIRLSNTIVFCGSI--IQVCICAVWLGTYPPFPDVDMHSE------- 743
Cdd:cd15047   80 GFTLVFGALFAKTWRIYRIFTNKK-----LKRIVIKDKQLLKIVGILllIDIIILILWTIVDPLKPTRVLVLSeisddvk 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 744 -FGQIILWCNEGSTFAFYCVLGYLGFLASLSLLIAFLARRLPD-SFNEAKTITFS-MLVFFSVWISFVPTYLSSKGKTMV 820
Cdd:cd15047  155 yEYVVHCCSSSNGIIWLGILLAYKGLLLLFGCFLAWKTRNVDIeEFNESKYIGISiYNVLFLSVIGVPLSFVLTDSPDTS 234
                        250       260
                 ....*....|....*....|...
gi 153792626 821 -AVEILSILASSAGLLGCIFLPK 842
Cdd:cd15047  235 yLIISAAILFCTTATLCLLFVPK 257
PBP1_taste_receptor cd06363
ligand-binding domain of the T1R taste receptor; Ligand-binding domain of the T1R taste ...
210-524 5.12e-12

ligand-binding domain of the T1R taste receptor; Ligand-binding domain of the T1R taste receptor. The T1R is a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptors, GABAb receptors, the calcium-sensing receptor (CaSR), the V2R pheromone receptors, and a small group of uncharacterized orphan receptors.


Pssm-ID: 380586 [Multi-domain]  Cd Length: 418  Bit Score: 68.87  E-value: 5.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 210 IIQLLLYFSWVWVGLVVPDDVRGELFLRDITEEMNNHGLCVAFAEKVPEFPA-----KDTVNRglfIERfTLTRVIVAFg 284
Cdd:cd06363  168 MVQLLQEFGWNWVAFLGSDDEYGQDGLQLFSEKAANTGICVAYQGLIPTDTDpkpkyQDILKK---INQ-TKVNVVVVF- 242
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 285 dtySLLRFAYNIFcNTPF-----GNVWITTSDW----DITTLSFRQNLsytyfGGELSFSVHTDEILGFKDFLRSvqprk 355
Cdd:cd06363  243 ---APKQAAKAFF-EEVIrqnltGKVWIASEAWslndTVTSLPGIQSI-----GTVLGFAIQTGTLPGFQEFIYA----- 308
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 356 ypqdifiqdvwsilfecpytylygirelsqceqngnlstrllyvwdmntspSSYKIHDAVYAIAQALHeelsfkleeNSL 435
Cdd:cd06363  309 ---------------------------------------------------FAFSVYAAVYAVAHALH---------NLL 328
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 436 NKDVSKAPHLWKLHPFLQNGQLGRST----NEEAVMNKEVS-ATKLDIFNYQSlQSGTKAQVKVGEFVFesYSVQnFSLN 510
Cdd:cd06363  329 GCNSGACPKGRVVYPWQLLEELKKVNftllNQTIRFDENGDpNFGYDIVQWIW-NNSSWTFEVVGSYST--YPIQ-LTIN 404
                        330
                 ....*....|....
gi 153792626 511 DKLITWGEHHNQTP 524
Cdd:cd06363  405 ESKIKWHTKDSPVP 418
ANF_receptor pfam01094
Receptor family ligand binding region; This family includes extracellular ligand binding ...
178-424 4.23e-10

Receptor family ligand binding region; This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.


Pssm-ID: 460062 [Multi-domain]  Cd Length: 347  Bit Score: 62.40  E-value: 4.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626  178 ISYAPFDQSLGTGVQlqSPYQFPVHTTALYQG--IIQLLLYFSWVWVGLVVPDDVRGELFLRDITEEMNNHGLCVAFAEK 255
Cdd:pfam01094  78 ISYGSTSPALSDLNR--YPTFLRTTPSDTSQAdaIVDILKHFGWKRVALIYSDDDYGESGLQALEDALRERGIRVAYKAV 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626  256 VPEFPAKDTVNRGLFIERFTLTRVIVAF---GDTYSLLRFAYNIfcN-TPFGNVWITTsDWDITTLSFRQNLSYTYFGGE 331
Cdd:pfam01094 156 IPPAQDDDEIARKLLKEVKSRARVIVVCcssETARRLLKAAREL--GmMGEGYVWIAT-DGLTTSLVILNPSTLEAAGGV 232
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626  332 LSFSVHTDEILGFKDFLRsvqprkypqdifiqdvwsilfecpytylygiRELSQCEQNGNLSTRllyvwdMNTSPSSYkI 411
Cdd:pfam01094 233 LGFRLHPPDSPEFSEFFW-------------------------------EKLSDEKELYENLGG------LPVSYGAL-A 274
                         250
                  ....*....|...
gi 153792626  412 HDAVYAIAQALHE 424
Cdd:pfam01094 275 YDAVYLLAHALHN 287
PBP1_GPC6A-like cd06361
ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a ...
201-353 4.10e-07

ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor; This family includes the ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor, and its fish homolog, the 5.24 chemoreceptor. GPRC6A is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into cellular responses.


Pssm-ID: 380584 [Multi-domain]  Cd Length: 401  Bit Score: 53.14  E-value: 4.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 201 VHTTalyQGIIQLLLYFSWVWVGLVVPDDVRGELFLRDITEEMNNHGLCVAFAEKVPEFPA--------KDTVNRglfIE 272
Cdd:cd06361  155 FHQT---KAMAKLISHFGWNWVGIIYTDDDYGRSALESFIIQAEAENVCIAFKEVLPAYLSdptmnvriNDTIQT---IQ 228
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 273 RFTLTRVIVAFGDTySLLRFAYNIFCNTPFGNVWITTSDWDiTTLSFRQNLSYTYFGGELSFSVHTDEILGFKDFLRSVQ 352
Cdd:cd06361  229 SSSQVNVVVLFLKP-SLVKKLFKEVIERNISKIWIASDNWS-TAREILKMPNINKVGKILGFTFKSGNISSFHNYLKNLL 306

                 .
gi 153792626 353 P 353
Cdd:cd06361  307 I 307
7tmC_GPR158-like cd15293
orphan GPR158 and similar proteins, member of the class C family of seven-transmembrane G ...
605-848 6.81e-07

orphan GPR158 and similar proteins, member of the class C family of seven-transmembrane G protein-coupled receptors; This group includes orphan receptors GPR158, GPR158-like (also called GPR179) and similar proteins. These orphan receptors are closely related to the type B receptor for gamma-aminobutyric acid (GABA-B), which is activated by its endogenous ligand GABA, the principal inhibitory neurotransmitter. The functional GABA-B receptor is an obligatory heterodimer composed of two related subunits, GABA-B1, which is primarily involved in GABA ligand binding, and GABA-B2, which is responsible for both G-protein coupling and trafficking of the heterodimer to the plasma membrane. Activation of GABA-B couples to G(i/o)-type G proteins, which in turn modulate three major downstream effectors: adenylate cyclase, voltage-sensitive Ca2+ channels, and inwardly-rectifying K+ channels. Consequently, GABA-B receptor produces slow and sustained inhibitory responses by decreased neurotransmitter release via inhibition of Ca2+ channels and by postsynaptic hyperpolarization via the activation of K+ channels through the G-protein beta-gamma dimer. The GABA-B is expressed in both pre- and postsynaptic sites of glutamatergic and GABAergic neurons in the brain where it regulates synaptic activity. Thus, the GABA-B receptor agonist, baclofen, is used to treat muscle tightness and cramping caused by spasticity in multiple sclerosis patients. Moreover, GABA-B antagonists improves cognitive performance in mammals, while GABA-B agonists suppress cognitive behavior. In most of the class C family members, the extracellular Venus-flytrap domain in the N-terminus is connected to the seven-transmembrane (7TM) via a cysteine-rich domain (CRD). However, in the GABA-B receptor, the CRD is absent in both subunits and the Venus-flytrap ligand-binding domain is directly connected to the 7TM via a 10-15 amino acids linker, suggesting that GABA-B receptor may utilize a different activation mechanism.


Pssm-ID: 320420  Cd Length: 252  Bit Score: 51.45  E-value: 6.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 605 VALSFSAFSAMILRLFIC----YRDTPIVRANNRNLSYLLLV-SLMLCFFCSLIFIgQPKTVTCVLRQVIFGVVFSVAVS 679
Cdd:cd15293    5 AVLAVQAICILLCLVLALvvfrFRKVKVIKAASPILLELILFgALLLYFPVFILYF-EPSVFRCILRPWFRHLGFAIVYG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 680 TILAKTFIVVVAFKAikpgsalKMSMVIRLSNTIVF--CGSIIQVCIC--AVWLGTYPPFPDVDMHSEFGQI------IL 749
Cdd:cd15293   84 ALILKTYRILVVFRS-------RSARRVHLTDRDLLkrLGLIVLVVLGylAAWTAVNPPNVEVGLTLTSSGLkfnvcsLD 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 750 WCN---EGSTFAFYCVLGYLgflaslslliAFLARRLPDSFNEAKTITFSMLVFFSVWISF---VPTYLSSKGKTMV-AV 822
Cdd:cd15293  157 WWDyvmAIAELLFLLWGVYL----------CYAVRKAPSAFNESRYISLAIYNELLLSVIFniiRFFLLPSLHPDLLfLL 226
                        250       260
                 ....*....|....*....|....*.
gi 153792626 823 EILSILASSAGLLGCIFLPKCYVILM 848
Cdd:cd15293  227 FFLHTQLTVTVTLLLIFGPKFYLVLR 252
PBP1_mGluR_groupII cd06375
ligand binding domain of the group II metabotropic glutamate receptor; Ligand binding domain ...
178-423 8.18e-06

ligand binding domain of the group II metabotropic glutamate receptor; Ligand binding domain of the group II metabotropic glutamate receptor, a family that contains mGlu2R and mGlu3R, all of which inhibit adenylyl cyclase. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes


Pssm-ID: 380598 [Multi-domain]  Cd Length: 462  Bit Score: 49.44  E-value: 8.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 178 ISYAPFDQSLGTgvqlQSPYQFPVHTTA--LYQGI--IQLLLYFSWVWVGLVVPDDVRGELFLRDITEEMNNHGLCVAFA 253
Cdd:cd06375  138 ISYASTSAKLSD----KSRYDYFARTVPpdFYQAKamAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATA 213
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 254 EKVPEFPAK---DTVNRGLFIERFtlTRVIVAF---GDTYSLLRFAYNIfcNTPFgnVWITTSDWDITTLSFRQNLSYTY 327
Cdd:cd06375  214 EKVGRSADRksfDGVIRELLQKPN--ARVVVLFtrsDDARELLAAAKRL--NASF--TWVASDGWGAQESIVKGSEDVAE 287
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626 328 fgGELSFSVHTDEILGFKDFLRSVQPRKYPQDIFIQDVWSILFECpytylygirELSQCEQNGNLSTRLLYVWDMNTSPS 407
Cdd:cd06375  288 --GAITLELASHPIPDFDRYFQSLTPYNNHRNPWFRDFWEQKFQC---------SLQNKSQAASVSDKHLSIDSSNYEQE 356
                        250
                 ....*....|....*....
gi 153792626 408 SyKIH---DAVYAIAQALH 423
Cdd:cd06375  357 S-KIMfvvNAVYAMAHALH 374
Mt_ATP-synt_D pfam05873
ATP synthase D chain, mitochondrial (ATP5H); This family consists of several ATP synthase D ...
81-171 1.44e-04

ATP synthase D chain, mitochondrial (ATP5H); This family consists of several ATP synthase D chain, mitochondrial (ATP5H) proteins. Subunit d has no extensive hydrophobic sequences, and is not apparently related to any subunit described in the simpler ATP synthases in bacteria and chloroplasts.


Pssm-ID: 461764 [Multi-domain]  Cd Length: 154  Bit Score: 42.99  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792626   81 PNSPTKINMDYpntpEKQDLVSKSylimMLEDFKKD--------VENSLREQVEAYREESQKCLKEFQENTIKQLKELKM 152
Cdd:pfam05873  44 PEEPPKIDWAY----YKKNVAKPG----LVDDFEKKyealkipyPEDTYTSEVDAQEKEVVKEIKEFIEESNKRIAEYEK 115
                          90       100       110
                  ....*....|....*....|....*....|...
gi 153792626  153 EIEAIKK----EHM----------ETTLDIENQ 171
Cdd:pfam05873 116 ELEKLKNllpfEQMtmedfceafpELALDPINK 148
CBD_MYO6-like cd21759
calmodulin binding domain found in unconventional myosin-VI and similar proteins; Myosins, ...
119-171 2.28e-03

calmodulin binding domain found in unconventional myosin-VI and similar proteins; Myosins, which are actin-based motor molecules with ATPase activity, include unconventional myosins that serve in intracellular movements. Myosin-VI, also called unconventional myosin-6 (MYO6), is a reverse-direction motor protein that moves towards the minus-end of actin filaments. It is required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Myosin-VI appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. It modulates RNA polymerase II-dependent transcription. As part of the DISP (DOCK7-Induced Septin disPlacement) complex, Myosin-VI may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Myosin-VI is encoded by gene MYO6, the human homolog of the gene responsible for deafness in Snell's waltzer mice. It is mutated in autosomal dominant non-syndromic hearing loss. This family also includes Drosophila melanogaster unconventional myosin VI Jaguar (Jar; also called myosin heavy chain 95F (Mhc95F), or 95F MHC), which is a motor protein necessary for the morphogenesis of epithelial tissues during Drosophila development. Jar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. It contributes to synaptic transmission and development at the Drosophila neuromuscular junction. Together with CLIP-190 (CAP-Gly domain-containing/cytoplasmic linker protein 190), Jar may coordinate the interaction between the actin and microtubule cytoskeleton. Jar may link endocytic vesicles to microtubules and possibly be involved in transport in the early embryo and in the dynamic process of dorsal closure; its function is believed to change during the life cycle. This model corresponds to the calmodulin (CaM) binding domain (CBD), which consists of three subdomains: a unique insert (Insert 2 or Ins2), an IQ motif, and a proximal tail domain (PTD, also known as lever arm extension or LAE).


Pssm-ID: 409646 [Multi-domain]  Cd Length: 149  Bit Score: 39.41  E-value: 2.28e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 153792626 119 NSLREQVEAYREESQKcLKEFQENTIKQLKELKMEIEA----IKKEHMETTLDIENQ 171
Cdd:cd21759   75 RALEKQLKEMEEIASQ-LKKDKDKWTKQVKELKKEIDAlikkIKTNDMITRKEIDKL 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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