SUMO-specific isopeptidase USPL1 isoform 2 [Rattus norvegicus]
Protein Classification
Peptidase_C98 domain-containing protein( domain architecture ID 10634616)
Peptidase_C98 domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| Peptidase_C98 | pfam15499 | Ubiquitin-specific peptidase-like, SUMO isopeptidase; Peptidase_C98 is a small family of SUMO ... |
215-487 | 4.37e-170 | |||||
Ubiquitin-specific peptidase-like, SUMO isopeptidase; Peptidase_C98 is a small family of SUMO - small ubiquitin-related modifier - isopeptidases found in eukaryotes. Reversible attachment of SUMO is an essential protein modification in all eukaryotic cells, The family neither binds nor cleaves ubiquitin, but is a potent SUMO isopeptidase, and the invariant residues required for SUMO binding and cleavage, in UniProtKB:Q5W0Q7, are Cys-236, His-456 and Asp-472, all of which are fully conserved in the family. Member proteins are low-abundance proteins that colocalize with coilin in Cajal bodies. Peptidase_C98 depletion does not affect global sumoylation, but causes striking coilin mis-localization and impairs cell proliferation, functions that are not dependent on the catalytic activity. Thus, Peptidase_C98 represents a third type of SUMO protease, with essential functions in Cajal body biology. : Pssm-ID: 464750 Cd Length: 272 Bit Score: 481.04 E-value: 4.37e-170
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| Name | Accession | Description | Interval | E-value | |||||
| Peptidase_C98 | pfam15499 | Ubiquitin-specific peptidase-like, SUMO isopeptidase; Peptidase_C98 is a small family of SUMO ... |
215-487 | 4.37e-170 | |||||
Ubiquitin-specific peptidase-like, SUMO isopeptidase; Peptidase_C98 is a small family of SUMO - small ubiquitin-related modifier - isopeptidases found in eukaryotes. Reversible attachment of SUMO is an essential protein modification in all eukaryotic cells, The family neither binds nor cleaves ubiquitin, but is a potent SUMO isopeptidase, and the invariant residues required for SUMO binding and cleavage, in UniProtKB:Q5W0Q7, are Cys-236, His-456 and Asp-472, all of which are fully conserved in the family. Member proteins are low-abundance proteins that colocalize with coilin in Cajal bodies. Peptidase_C98 depletion does not affect global sumoylation, but causes striking coilin mis-localization and impairs cell proliferation, functions that are not dependent on the catalytic activity. Thus, Peptidase_C98 represents a third type of SUMO protease, with essential functions in Cajal body biology. Pssm-ID: 464750 Cd Length: 272 Bit Score: 481.04 E-value: 4.37e-170
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| Name | Accession | Description | Interval | E-value | |||||
| Peptidase_C98 | pfam15499 | Ubiquitin-specific peptidase-like, SUMO isopeptidase; Peptidase_C98 is a small family of SUMO ... |
215-487 | 4.37e-170 | |||||
Ubiquitin-specific peptidase-like, SUMO isopeptidase; Peptidase_C98 is a small family of SUMO - small ubiquitin-related modifier - isopeptidases found in eukaryotes. Reversible attachment of SUMO is an essential protein modification in all eukaryotic cells, The family neither binds nor cleaves ubiquitin, but is a potent SUMO isopeptidase, and the invariant residues required for SUMO binding and cleavage, in UniProtKB:Q5W0Q7, are Cys-236, His-456 and Asp-472, all of which are fully conserved in the family. Member proteins are low-abundance proteins that colocalize with coilin in Cajal bodies. Peptidase_C98 depletion does not affect global sumoylation, but causes striking coilin mis-localization and impairs cell proliferation, functions that are not dependent on the catalytic activity. Thus, Peptidase_C98 represents a third type of SUMO protease, with essential functions in Cajal body biology. Pssm-ID: 464750 Cd Length: 272 Bit Score: 481.04 E-value: 4.37e-170
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