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Conserved domains on  [gi|157823385|ref|NP_001099527|]
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SLIT and NTRK-like protein 6 precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-219 2.80e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 2.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385  68 HLSLLNNGLTTLHTnDFSGLTNALSIHLGFNNIADIeTGAFNGLGLLKQLHINHNSLEILKEdTFHGLENLEFLQADNNF 147
Cdd:COG4886  140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQ 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157823385 148 ITVIEQSaFSKLNRLKVLILNDNAIESLPpNIFRFVPLTHLDLRGNQLQTLPyvgFLEHIGRILDLQLEDNK 219
Cdd:COG4886  217 LTDLPEP-LANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
388-516 3.28e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 3.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385 388 LEMLHLGNNRIEVLEEgSFMNLTRLQKLYLNGNHLTKLYKGmFLGLSSLEYLYLEYNAVKEIlPGTFNPMPKLKVLYLNN 467
Cdd:COG4886  115 LESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSN 191

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 157823385 468 NLLHVLPAHIFLGIPLTRVNLKTNQFTHLPVSniLDDLDLLIQIDLEDN 516
Cdd:COG4886  192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNN 238
LRRCT smart00082
Leucine rich repeat C-terminal domain;
516-566 1.38e-06

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 1.38e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 157823385   516 NPWDCSCDLVGLQQWIHKLGKGTVTDDILCASPGHLDKKELKALNSELLCP 566
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
218-268 6.28e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.18  E-value: 6.28e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 157823385   218 NKWACNCELLQLKNWLEN--MPPQSiiGDVICYSPPLFKGSILSRLKKESICP 268
Cdd:smart00082   1 NPFICDCELRWLLRWLQAneHLQDP--VDLRCASPSSLRGPLLELLHSEFKCP 51
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-219 2.80e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 2.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385  68 HLSLLNNGLTTLHTnDFSGLTNALSIHLGFNNIADIeTGAFNGLGLLKQLHINHNSLEILKEdTFHGLENLEFLQADNNF 147
Cdd:COG4886  140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQ 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157823385 148 ITVIEQSaFSKLNRLKVLILNDNAIESLPpNIFRFVPLTHLDLRGNQLQTLPyvgFLEHIGRILDLQLEDNK 219
Cdd:COG4886  217 LTDLPEP-LANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
388-516 3.28e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 3.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385 388 LEMLHLGNNRIEVLEEgSFMNLTRLQKLYLNGNHLTKLYKGmFLGLSSLEYLYLEYNAVKEIlPGTFNPMPKLKVLYLNN 467
Cdd:COG4886  115 LESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSN 191

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 157823385 468 NLLHVLPAHIFLGIPLTRVNLKTNQFTHLPVSniLDDLDLLIQIDLEDN 516
Cdd:COG4886  192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNN 238
LRR_8 pfam13855
Leucine rich repeat;
387-444 1.51e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.93  E-value: 1.51e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 157823385  387 TLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLYKGMFLGLSSLEYLYLEYN 444
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 344-517 3.60e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 3.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385 344 IHCQERNIESVSDLQPPPhNPRKLILAGNIIHTLMKADLMDYftLEMLHLGNNRIEVLEegSFMNLTRLQKLYLNGNHLT 423
Cdd:cd21340    7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKIENLEFLTN--LTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385 424 KLyKGmFLGLSSLEYLYLEYNAVKEILPGTFNPM------PKLKVLYL-NNNL-----LHVLPAhiflgipLTRVNLKTN 491
Cdd:cd21340   82 VV-EG-LENLTNLEELHIENQRLPPGEKLTFDPRslaalsNSLRVLNIsGNNIdslepLAPLRN-------LEQLDASNN 152

                        170       180
                 ....*....|....*....|....*..
gi 157823385 492 QFTHL-PVSNILDDLDLLIQIDLEDNP 517
Cdd:cd21340  153 QISDLeELLDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
92-146 1.81e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.81e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 157823385   92 SIHLGFNNIADIETGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNN 146
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 68-218 6.75e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 6.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385  68 HLSLLNNGLTTLhtNDFSGLTNALSIHLGFNNIADIEtgAFNGLGLLKQLHINHNSLEILkeDTFHGLENLEFLQADNNF 147
Cdd:cd21340    6 HLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385 148 ITVIE----------------------------QSAFSKLNRLKVLILNDNAIESLPPnIFRFVPLTHLDLRGNQLQTLP 199
Cdd:cd21340   80 ISVVEglenltnleelhienqrlppgekltfdpRSLAALSNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLE 158

                        170       180
                 ....*....|....*....|
gi 157823385 200 YV-GFLEHIGRILDLQLEDN 218
Cdd:cd21340  159 ELlDLLSSWPSLRELDLTGN 178
LRRCT smart00082
Leucine rich repeat C-terminal domain;
516-566 1.38e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 1.38e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 157823385   516 NPWDCSCDLVGLQQWIHKLGKGTVTDDILCASPGHLDKKELKALNSELLCP 566
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 386-516 3.89e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 3.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385 386 FTLEMLHLGNNRIE---VLEEGSFMNLTRLQklyLNGNHLTKLYKGMFLGLSSLEYLYLEYNAVKEILPGTFNPMPKLKV 462
Cdd:PLN00113 140 PNLETLDLSNNMLSgeiPNDIGSFSSLKVLD---LGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKW 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157823385 463 LYLN-NNLLHVLPAHI---------------FLG-IPLTRVNLKTNQFTHL-------PVSNILDDLDLLIQIDLEDN 516
Cdd:PLN00113 217 IYLGyNNLSGEIPYEIggltslnhldlvynnLTGpIPSSLGNLKNLQYLFLyqnklsgPIPPSIFSLQKLISLDLSDN 294
LRRCT smart00082
Leucine rich repeat C-terminal domain;
218-268 6.28e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.18  E-value: 6.28e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 157823385   218 NKWACNCELLQLKNWLEN--MPPQSiiGDVICYSPPLFKGSILSRLKKESICP 268
Cdd:smart00082   1 NPFICDCELRWLLRWLQAneHLQDP--VDLRCASPSSLRGPLLELLHSEFKCP 51
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-219 2.80e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 2.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385  68 HLSLLNNGLTTLHTnDFSGLTNALSIHLGFNNIADIeTGAFNGLGLLKQLHINHNSLEILKEdTFHGLENLEFLQADNNF 147
Cdd:COG4886  140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQ 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157823385 148 ITVIEQSaFSKLNRLKVLILNDNAIESLPpNIFRFVPLTHLDLRGNQLQTLPyvgFLEHIGRILDLQLEDNK 219
Cdd:COG4886  217 LTDLPEP-LANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-213 5.09e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 5.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385  69 LSLLNNGLTTLhTNDFSGLTNALSIHLGFNNIADIETgAFNGLGLLKQLHINHNSLEILKEDtFHGLENLEFLQADNNFI 148
Cdd:COG4886  118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQI 194

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157823385 149 TVIEqSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIgRILDL 213
Cdd:COG4886  195 TDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL-EELDL 257
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
388-516 3.28e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 3.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385 388 LEMLHLGNNRIEVLEEgSFMNLTRLQKLYLNGNHLTKLYKGmFLGLSSLEYLYLEYNAVKEIlPGTFNPMPKLKVLYLNN 467
Cdd:COG4886  115 LESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSN 191

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 157823385 468 NLLHVLPAHIFLGIPLTRVNLKTNQFTHLPVSniLDDLDLLIQIDLEDN 516
Cdd:COG4886  192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNN 238
LRR_8 pfam13855
Leucine rich repeat;
387-444 1.51e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.93  E-value: 1.51e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 157823385  387 TLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLYKGMFLGLSSLEYLYLEYN 444
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
410-470 6.28e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 6.28e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157823385  410 TRLQKLYLNGNHLTKLYKGMFLGLSSLEYLYLEYNAVKEILPGTFNPMPKLKVLYLNNNLL 470
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 344-517 3.60e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 3.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385 344 IHCQERNIESVSDLQPPPhNPRKLILAGNIIHTLMKADLMDYftLEMLHLGNNRIEVLEegSFMNLTRLQKLYLNGNHLT 423
Cdd:cd21340    7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKIENLEFLTN--LTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385 424 KLyKGmFLGLSSLEYLYLEYNAVKEILPGTFNPM------PKLKVLYL-NNNL-----LHVLPAhiflgipLTRVNLKTN 491
Cdd:cd21340   82 VV-EG-LENLTNLEELHIENQRLPPGEKLTFDPRslaalsNSLRVLNIsGNNIdslepLAPLRN-------LEQLDASNN 152

                        170       180
                 ....*....|....*....|....*..
gi 157823385 492 QFTHL-PVSNILDDLDLLIQIDLEDNP 517
Cdd:cd21340  153 QISDLeELLDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
92-146 1.81e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.81e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 157823385   92 SIHLGFNNIADIETGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNN 146
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
363-516 3.06e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.95  E-value: 3.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385 363 NPRKLILAGNIIHTLMKADLMDYFTLEMLHLGNNRievleegSFMNLTRLQKLYLNGNHLTKLYKGMFlGLSSLEYLYLE 442
Cdd:COG4886   73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELA-NLTNLKELDLS 144

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157823385 443 YNAVKEIlPGTFNPMPKLKVLYLNNNLLHVLPAHIFLGIPLTRVNLKTNQFTHLPVSniLDDLDLLIQIDLEDN 516
Cdd:COG4886  145 NNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP--LGNLTNLEELDLSGN 215
LRR_8 pfam13855
Leucine rich repeat;
137-195 3.34e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 3.34e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385  137 NLEFLQADNNFITVIEQSAFSKLNRLKVLILNDNAIESLPPNIFRFVP-LTHLDLRGNQL 195
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-199 6.74e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.79  E-value: 6.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385  43 IMIINCEEKGINTLSQISVPPSRPFHLSLLNNGLTTLHTNDFSGLTNALSIHLGFNNIADIETGAFNGLGLLKQLHinhn 122
Cdd:COG4886   24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT---- 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157823385 123 SLEILKEDTFHGLENLEFLQADNNFITVIEQSaFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLP 199
Cdd:COG4886  100 ELDLSGNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLP 175
LRR_8 pfam13855
Leucine rich repeat;
114-172 1.23e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.23e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 157823385  114 LKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEQSAFSKLNRLKVLILNDNAI 172
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-219 4.34e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 4.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385  68 HLSLLNNGLTTLHtNDFSGLTNALSIHLGFNNIADIETgAFNGLGLLKQLHINHNSLEILKEdtFHGLENLEFLQADNNF 147
Cdd:COG4886  186 ELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQ 261

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157823385 148 ITVIeqSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNK 219
Cdd:COG4886  262 LTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-615 5.12e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 5.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385  95 LGFNNIADIETGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNfitvieqSAFSKLNRLKVLILNDNAIES 174
Cdd:COG4886   55 LLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTD 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385 175 LPPNIFRFVPLTHLDLRGNQLQTLP-YVGFLEHIgRILDLQlednkwacNCELLQLKNWLENMPpqsiigdvicyspplf 253
Cdd:COG4886  128 LPEELANLTNLKELDLSNNQLTDLPePLGNLTNL-KSLDLS--------NNQLTDLPEELGNLT---------------- 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385 254 kgsilsrlkkesicptppvyeehedpagsllaitsstsdsrlsskntsilkqptkapgsvpyltkpstqlpvpycpvpcn 333
Cdd:COG4886      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385 334 ckvlspsgllihcqerniesvsdlqppphnprklilagniihtlmkadlmdyfTLEMLHLGNNRIEVLEEgSFMNLTRLQ 413
Cdd:COG4886  183 -----------------------------------------------------NLKELDLSNNQITDLPE-PLGNLTNLE 208

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385 414 KLYLNGNHLTKLYKGmFLGLSSLEYLYLEYNAVKEiLPGTFNpMPKLKVLYLNNNLLHVLPAHIFLGiPLTRVNLKTNQF 493
Cdd:COG4886  209 ELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTD-LPELGN-LTNLEELDLSNNQLTDLPPLANLT-NLKTLDLSNNQL 284

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385 494 THLPVSNiLDDLDLLIQIDLEDNPWDCSCDLVGLQQWIHKLGKGTVTDDILCASPGHLDKKELKALNSELLCPGLVNNPS 573
Cdd:COG4886  285 TDLKLKE-LELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLL 363

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|..
gi 157823385 574 MPTQTSYIIVTSPTMAADAAGTLLSSLTDAVPLSVLILGLLI 615
Cdd:COG4886  364 TLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTL 405
LRR_8 pfam13855
Leucine rich repeat;
365-422 5.50e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 5.50e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 157823385  365 RKLILAGNIIHTLMKADLMDYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHL 422
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 68-218 6.75e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 6.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385  68 HLSLLNNGLTTLhtNDFSGLTNALSIHLGFNNIADIEtgAFNGLGLLKQLHINHNSLEILkeDTFHGLENLEFLQADNNF 147
Cdd:cd21340    6 HLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385 148 ITVIE----------------------------QSAFSKLNRLKVLILNDNAIESLPPnIFRFVPLTHLDLRGNQLQTLP 199
Cdd:cd21340   80 ISVVEglenltnleelhienqrlppgekltfdpRSLAALSNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLE 158

                        170       180
                 ....*....|....*....|
gi 157823385 200 YV-GFLEHIGRILDLQLEDN 218
Cdd:cd21340  159 ELlDLLSSWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 68-199 1.27e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 1.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385  68 HLSLLNNGLTTLhtNDFSGLTNALSIHLGFNNIADIEtgAFNGLGLLKQLHINHNSLE-----ILKEDTFHGL-ENLEFL 141
Cdd:cd21340   50 HLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPpgeklTFDPRSLAALsNSLRVL 125

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157823385 142 QADNNFITVIEQsaFSKLNRLKVLILNDNAIESLPpNIFRFVP----LTHLDLRGNQLQTLP 199
Cdd:cd21340  126 NISGNNIDSLEP--LAPLRNLEQLDASNNQISDLE-ELLDLLSswpsLRELDLTGNPVCKKP 184
LRRCT smart00082
Leucine rich repeat C-terminal domain;
516-566 1.38e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 1.38e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 157823385   516 NPWDCSCDLVGLQQWIHKLGKGTVTDDILCASPGHLDKKELKALNSELLCP 566
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
434-493 5.57e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 5.57e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157823385  434 SSLEYLYLEYNAVKEILPGTFNPMPKLKVLYLNNNLLHVLPAHIFLGIP-LTRVNLKTNQF 493
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 98-193 7.75e-06

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 46.00  E-value: 7.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385   98 NNIADIETGAFNGLGLLKQLHINhNSLEILKEDTFHG--LENLEFlqadNNFITVIEQSAFSKLNRLKVLILNDNaIESL 175
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLP-SSLTSIGSYAFYNcsLTSITI----PSSLTSIGEYAFSNCSNLKSITLPSN-LTSI 93

                          90
                  ....*....|....*...
gi 157823385  176 PPNIFRFVPLTHLDLRGN 193
Cdd:pfam13306  94 GSYAFSNCSLKSITIPSS 111
LRR_8 pfam13855
Leucine rich repeat;
69-124 1.74e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.74e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 157823385   69 LSLLNNGLTTLHTNDFSGLTNALSIHLGFNNIADIETGAFNGLGLLKQLHINHNSL 124
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 72-180 1.81e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 42.15  E-value: 1.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385   72 LNNGLTTLHTNDFSGLTNALSIHLGfNNIADIETGAFNGLGlLKQLHINhNSLEILKEDTFHGLENLEFLQADNNfITVI 151
Cdd:pfam13306  18 IPSSLTSIGEYAFSNCTSLKSITLP-SSLTSIGSYAFYNCS-LTSITIP-SSLTSIGEYAFSNCSNLKSITLPSN-LTSI 93

                          90       100
                  ....*....|....*....|....*....
gi 157823385  152 EQSAFSKLNrLKVLILNDNaIESLPPNIF 180
Cdd:pfam13306  94 GSYAFSNCS-LKSITIPSS-VTTIGSYAF 120
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 386-516 3.89e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 3.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385 386 FTLEMLHLGNNRIE---VLEEGSFMNLTRLQklyLNGNHLTKLYKGMFLGLSSLEYLYLEYNAVKEILPGTFNPMPKLKV 462
Cdd:PLN00113 140 PNLETLDLSNNMLSgeiPNDIGSFSSLKVLD---LGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKW 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157823385 463 LYLN-NNLLHVLPAHI---------------FLG-IPLTRVNLKTNQFTHL-------PVSNILDDLDLLIQIDLEDN 516
Cdd:PLN00113 217 IYLGyNNLSGEIPYEIggltslnhldlvynnLTGpIPSSLGNLKNLQYLFLyqnklsgPIPPSIFSLQKLISLDLSDN 294
LRRCT smart00082
Leucine rich repeat C-terminal domain;
218-268 6.28e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.18  E-value: 6.28e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 157823385   218 NKWACNCELLQLKNWLEN--MPPQSiiGDVICYSPPLFKGSILSRLKKESICP 268
Cdd:smart00082   1 NPFICDCELRWLLRWLQAneHLQDP--VDLRCASPSSLRGPLLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
161-219 6.73e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 6.73e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385  161 RLKVLILNDNAIESLPPNIFRFVP-LTHLDLRGNQLQTLPYVGFlEHIGRILDLQLEDNK 219
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSnLKVLDLSNNLLTTLSPGAF-SGLPSLRYLDLSGNR 60
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 396-488 5.30e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.91  E-value: 5.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823385  396 NRIEVLEEGSFMNLTRLQKLYLNGNhLTKLYKGMFLGlSSLEYLYLEyNAVKEILPGTFNPMPKLKVLYLNNNlLHVLPA 475
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYN-CSLTSITIP-SSLTSIGEYAFSNCSNLKSITLPSN-LTSIGS 95

                          90
                  ....*....|...
gi 157823385  476 HIFLGIPLTRVNL 488
Cdd:pfam13306  96 YAFSNCSLKSITI 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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