NCBI Conserved Domain Search

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 211.46 E-value: 1.71e-63

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  261 GTVTEFKHPGHFYVQLYSSEVLEYMNQLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEGVDVLQKKAHV 340
Cdd:cd20408     1 GTVTEFKNPGEFYIQIYTLEVLESLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQKKAGV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 157818831  341 LYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGEWTEDCV 390
Cdd:cd20408    81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 198.05 E-value: 4.33e-59

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  937 ANVLEIISPTLFYAIPSEMPENQEKLCVLTAELLEHCNAQKGQPPYRPRTGEACCAKYTNDDFWYRAIVLEASDSDVKVL 1016
Cdd:cd20411     1 ALVLEVISPDLFYALPKTGQVNVEKLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLETSDSEVKVL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 157818831 1017 YADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEG 1052
Cdd:cd20411    81 YADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 146.06 E-value: 3.20e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  511 GHKLAELQESLSEYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPK 590
Cdd:cd20409     1 GRQLAELQESLSAYCKVAPASSDFSPAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPS 80


                  ..
gi 157818831  591 LL 592
Cdd:cd20409    81 LL 82

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 128.63 E-value: 1.15e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831   488 DEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCSHVtPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESVL 567
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASK-PPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVE 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 157818831   568 VGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAG 605
Cdd:pfam00567   80 VLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 127.86 E-value: 1.96e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831   708 ETVDVMVCMMHSPGEFYCHclKDDALKKLDDLNKSLADYCAQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGNV 787
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQ--PKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLV 78

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 157818831   788 KVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWL 824
Cdd:pfam00567   79 EVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQL 115

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 114.75 E-value: 1.17e-30

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 157818831  755 FKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFL 813
Cdd:cd20410     1 FKPIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 113.60 E-value: 2.02e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831   257 MEIKGTVTEFKHPGHFYVQlySSEVLEYMNQLSASLKETYANMVPEdGYLPVKGEVCVAKYTVDQTWNRAVVEgVDVLQK 336
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQ--PKSDSKKLEKLTEELQEYYASKPPE-SLPPAVGDGCVAAFSEDGKWYRAKIT-ESLDDG 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 157818831   337 KAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSG 377
Cdd:pfam00567   77 LVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 109.37 E-value: 5.76e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831   933 KTVPANVLEIISPTLFYAIPSEmpeNQEKLCVLTAELLEHCNaQKGQPPYRPRTGEACCAKYTNDDFWYRAIVLE-ASDS 1011
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKS---DSKKLEKLTEELQEYYA-SKPPESLPPAVGDGCVAAFSEDGKWYRAKITEsLDDG 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 157818831  1012 DVKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEG 1052
Cdd:pfam00567   77 LVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 105.22 E-value: 1.60e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  513 KLAELQESLSEYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAyASEESVLVGYVDYGNFEILSLKRLCPIIPKLL 592
Cdd:cd20411    25 KLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLE-TSDSEVKVLYADYGNTETLPLSRILPITKSHL 103

                          90
                  ....*....|...
gi 157818831  593 DLPMQALNCVLAG 605
Cdd:cd20411   104 ELPFQIIRCSLAG 116

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 96.67 E-value: 2.16e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  492 GVVAHIQTPEDFF--CQQLQSGHKLAELQESLSEYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAY-ASEESVLV 568
Cdd:cd20408     1 GTVTEFKNPGEFYiqIYTLEVLESLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVdVQQKKAGV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 157818831  569 GYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGMWTPEAI 618
Cdd:cd20408    81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 93.20 E-value: 3.88e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  939 VLEIISPTLFYAIPsEMPENQEKLCVLTAELLEHCNAQKGQPPYRPRTGEACCAKYTNDDFWYRAIV--LEASDSDVKVL 1016
Cdd:cd20408     3 VTEFKNPGEFYIQI-YTLEVLESLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVqtVDVQQKKAGVF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 157818831 1017 YADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEGLTELNGS 1059
Cdd:cd20408    82 YIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGS 124

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 92.55 E-value: 5.02e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  482 LTLNVGDEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCSHvtpRSDFYPTIGDMCCAQFSEDDQWYRASVLAYA 561
Cdd:cd20439     4 YLFKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSLMKQIQSYYLI---HNDPYKHGQIACVAKYSKDGKWYRAAVLKQV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 157818831  562 SEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGV 606
Cdd:cd20439    81 SAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 89.83 E-value: 4.33e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  270 GHFYVQLYSSEVLE-YMNQLSA-SLKETYAnmvPEDGYLPVKGEVCVAKYTVDQTWNRAVV-----EGVDVLQKKAHVLY 342
Cdd:cd20443     2 GRFYVQVVSDQRLSsIQQQLEGlSLKDKAN---PPGGFNPKKGELVLAQFSADNSWNRAMVvnaprQGTQSPKDEYEVFY 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 157818831  343 IDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGV-VP 380
Cdd:cd20443    79 IDYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAHIkVP 117

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 87.12 E-value: 3.18e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  719 SPGEFYC-HCLKDDALKKLDDLNKSLADYC-AQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSgNVKVHFVDYGN 796
Cdd:cd20411     8 SPDLFYAlPKTGQVNVEKLKALMTELAEYCsKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLETSDS-EVKVLYADYGN 86

                          90       100
                  ....*....|....*....|....*...
gi 157818831  797 VEEVTTDQLHAIAPQFLLLPFQGMQCWL 824
Cdd:cd20411    87 TETLPLSRILPITKSHLELPFQIIRCSL 114

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 83.96 E-value: 5.98e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  719 SPGEFYCHCLKDDALKKLDDLNKSLAD-YCAQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGN-VKVHFVDYGN 796
Cdd:cd20408     8 NPGEFYIQIYTLEVLESLVKLTSQLKKtYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQKkAGVFYIDYGN 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 157818831  797 VEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKHWTKEA 838
Cdd:cd20408    88 EETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEEC 129

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 84.09 E-value: 7.36e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  492 GVVAHIQTPEDFFCQQlqSGHKLAELQESLSEYCSHVTPRSDFYPTI--GDMCCAQFSEDDQWYRASVLAYASEEsVLVG 569
Cdd:cd20426     3 AYATAVDSPEYFWCQF--ATEKIQCLAVKVQEAGEQVADRGNFIPSIyvGDPCIVKYSEDNHWYRALVTKINDNL-VSVR 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 157818831  570 YVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGMWTPEA 617
Cdd:cd20426    80 FVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEA 127

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 81.19 E-value: 1.59e-18

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157818831  285 MNQLSaslKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEGVDVlQKKAHVLYIDYGNEEIIPVDRIHQL 359
Cdd:cd20433     9 MEKLR---FEIASNPPLPGSYTPRKGDLCAAKFVEDGEWYRAKVEKVEG-DKKVHVLYIDYGNREVLPSTRLAAL 79

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 80.96 E-value: 2.18e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  960 EKLCVLTAELLEHCNAQKGQPPYRPRTGEACCAKYTNDDFWYRAIVLE-ASDSDVKVLYADYGNVERLPFSRVQPITASH 1038
Cdd:cd20409     2 RQLAELQESLSAYCKVAPASSDFSPAVGEVCCAQFTEDNQWYRASVLAySSEDSVLVGYIDFGNSEEVALSRLRPIPPSL 81


                  .
gi 157818831 1039 L 1039
Cdd:cd20409    82 L 82

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 75.41 E-value: 2.06e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  734 KKLDDLNKSLADYCAQKPPNGFKAE--VGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQ 811
Cdd:cd20412     4 LQLDKLVQEMTQYYESEENRHTLLTvqVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALRSD 83

                          90
                  ....*....|.
gi 157818831  812 FLLLPFQGMQC 822
Cdd:cd20412    84 FLSLPFQAIEC 94

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 74.64 E-value: 3.51e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  510 SGHKLAELQESL-SEYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPII 588
Cdd:cd20433     1 TGPQLEKLMEKLrFEIASNPPLPGSYTPRKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALP 80


                  .
gi 157818831  589 P 589
Cdd:cd20433    81 P 81

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 74.81 E-value: 8.40e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  504 FCQQLQSGHKLAELQESLSEYC--SHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVL------AYASEESVLVGYVDYGN 575
Cdd:cd20443     4 FYVQVVSDQRLSSIQQQLEGLSlkDKANPPGGFNPKKGELVLAQFSADNSWNRAMVVnaprqgTQSPKDEYEVFYIDYGN 83

                          90       100       110
                  ....*....|....*....|....*....|...
gi 157818831  576 FEILSLKRLCPIIPKLLDLPMQALNCVLAGVKP 608
Cdd:cd20443    84 QETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 74.03 E-value: 1.97e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  712 VMVCMMHSPGEFYCHCLKDDALkkLDDLNKSLADYCAQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHF 791
Cdd:cd20440    14 VYITHVYSPAKFYCQLDRNTEI--LEALMEKIAEISKLFNSQILDNCKTRLCLAKYFEDGQWYRALAHPVESSSHLSVYF 91

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 157818831  792 VDYGNVEEVTTDQLHAI---APQFLLLPFQGMQCWL 824
Cdd:cd20440    92 VDYGNKQIVEKNEVLPIpdtAVDLLLTPMQAIKCCL 127

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 71.01 E-value: 2.29e-15

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 157818831  759 VGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAI 808
Cdd:cd20379     1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 73.22 E-value: 3.30e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  706 VDETVDVMVCMMHSPGEFYCHCLKDDalKKLDDLNKSLADYCAQKppngfKAEVGRPC------CACFAGDGNWYRALVK 779
Cdd:cd20437     1 VGTTEKVKITAAVSPSKFYCQLLSWE--PELSKLTTQMTLHYESV-----SKELNPSCenfgllCAAKGKDGQWHRGFLQ 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 157818831  780 EILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWL 824
Cdd:cd20437    74 QLLPPSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 71.18 E-value: 5.81e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  735 KLDDLNKSLADYCAQKPPNG--FKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQF 812
Cdd:cd20433     4 QLEKLMEKLRFEIASNPPLPgsYTPRKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALPPAF 83

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 70.06 E-value: 5.89e-15

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 157818831  534 FYPTIGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKLL 592
Cdd:cd20410     1 FKPIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 71.75 E-value: 1.13e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  704 FTVDETVDVMVCMMHSPGEFYCHCLKDdaLKKLDDLNKSLADYCAqkppngFKAEVGRPC-CACFA---GDGNWYRALVK 779
Cdd:cd20439     6 FKPGSVVDVKCSYVNSPGDFWCQLQTK--SSELKSLMKQIQSYYL------IHNDPYKHGqIACVAkysKDGKWYRAAVL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 157818831  780 EILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDI 827
Cdd:cd20439    78 KQVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 69.08 E-value: 1.23e-14

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 157818831  538 IGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPI 587
Cdd:cd20379     1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 69.82 E-value: 1.55e-14

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157818831  542 CCAQFSEDDQWYRASVL-AYASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLG 611
Cdd:cd20423     9 CLAKYSEDGKWCRALIDnVYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSG 79

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 69.25 E-value: 2.76e-14

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157818831  978 GQPPYRPRTGEACCAKYTNDDFWYRAIVlEASDSD--VKVLYADYGNVERLPFSRVQPITAS 1037
Cdd:cd20433    22 LPGSYTPRKGDLCAAKFVEDGEWYRAKV-EKVEGDkkVHVLYIDYGNREVLPSTRLAALPPA 82

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 69.41 E-value: 5.97e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  710 VDVMVCMMHSPGEFYCHCLKDDALKKL--DDLN--KSLADYCAQKPPNgfkaeVGRPCCACFAGDGNWYRALVKEILPSG 785
Cdd:cd20425     2 TEVYVSHVNSPSDFYVQLAQDEDELSMisEKLNasKANDEEVECESLQ-----LGDLICAEYPEDGLWYRAVVKEKIPNN 76

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 157818831  786 NVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWL 824
Cdd:cd20425    77 LVSVQFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 69.85 E-value: 7.23e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  711 DVMVCMMHSPGEFYCHcLKDDALKkLDDLNKSLAD-YCAQKPPNGF--KAEVGRPCCACFAGDGnWYRALVKEILPSGnV 787
Cdd:cd20422     3 DAQVEFVKDPSEFWIR-LGEHAVP-FSKLMRSMTAfYSQASKLDGVvlKPQPGQLCCAKWKEDR-YYRAIVTAVKGKM-V 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 157818831  788 KVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKHWTKEATARFQ 843
Cdd:cd20422    79 EVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFK 134

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 68.23 E-value: 8.30e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  514 LAELQEslsEYCSHVTPRSDFY-PTIGDMCCAQFsEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKLL 592
Cdd:cd20415     5 TKKIQE---FYKEGDDGGLEILcPVQGQACVALF-EDGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFL 80

                          90
                  ....*....|....*.
gi 157818831  593 DLPMQALNCVLAGVKP 608
Cdd:cd20415    81 SLPEKARECRLAFIEP 96

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 69.02 E-value: 8.98e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  494 VAHIQTPEDFFCQQLQSGHKLAELQESLSEYcSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDY 573
Cdd:cd20440    16 ITHVYSPAKFYCQLDRNTEILEALMEKIAEI-SKLFNSQILDNCKTRLCLAKYFEDGQWYRALAHPVESSSHLSVYFVDY 94

                          90       100       110
                  ....*....|....*....|....*....|...
gi 157818831  574 GNFEILSLKRLCPI---IPKLLDLPMQALNCVL 603
Cdd:cd20440    95 GNKQIVEKNEVLPIpdtAVDLLLTPMQAIKCCL 127

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 68.63 E-value: 1.14e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  263 VTEFKHPGHFY-VQLYSSEVLEYMNQLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVegVDVLQKKAHVL 341
Cdd:cd20411     3 VLEVISPDLFYaLPKTGQVNVEKLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTGDKNWYRAVV--LETSDSEVKVL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 157818831  342 YIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSG 377
Cdd:cd20411    81 YADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 69.04 E-value: 1.30e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  756 KAEVGRPCCACFAGDGNWYRALVKEILpSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKHWT 835
Cdd:cd20438    54 KPEPGLLCCARYSKDRHYYRAVITEVL-DLKVSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWT 132


                  ....*...
gi 157818831  836 KEATARFQ 843
Cdd:cd20438   133 KNANDFFK 140

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 67.82 E-value: 1.36e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  532 SDFYPtigDM-CCAQFSeDDQWYRASVLAYASEESV--LVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKP 608
Cdd:cd20418     2 TDFRP---EMpCLAEYS-DGKWYRAKLLSILEFNPVkiLVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKP 77

                          90       100
                  ....*....|....*....|....
gi 157818831  609 SLGM-----------WTPEAICVM 621
Cdd:cd20418    78 PLNDseteripycpeWSMKALWAM 101

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 66.71 E-value: 1.85e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  735 KLDDLNKSLADYCAQKPPN-GFKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFL 813
Cdd:cd20409     3 QLAELQESLSAYCKVAPASsDFSPAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPSLL 82

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 68.31 E-value: 2.59e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  490 FC-GVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCSHVTPRSDFY--PTIGDMCCAQFsEDDQWYRASVLAyASEESV 566
Cdd:cd20422     1 FYdAQVEFVKDPSEFWIRLGEHAVPFSKLMRSMTAFYSQASKLDGVVlkPQPGQLCCAKW-KEDRYYRAIVTA-VKGKMV 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 157818831  567 LVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGMWTPEAICVMRK 623
Cdd:cd20422    79 EVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFKR 135

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 67.48 E-value: 2.93e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  494 VAHIQTPEDFFCQQLQSGHKLAELQESLSEYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDY 573
Cdd:cd20425     6 VSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVECESLQLGDLICAEYPEDGLWYRAVVKEKIPNNLVSVQFIDY 85

                          90       100       110
                  ....*....|....*....|....*....|
gi 157818831  574 GNFEILSLKRLCPIIPKLLDLPMQALNCVL 603
Cdd:cd20425    86 GNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 65.39 E-value: 7.15e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  513 KLAELQESLSEYCSHVTPRSDF-YPTIGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKL 591
Cdd:cd20412     5 QLDKLVQEMTQYYESEENRHTLlTVQVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALRSDF 84

                          90
                  ....*....|
gi 157818831  592 LDLPMQALNC 601
Cdd:cd20412    85 LSLPFQAIEC 94

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 64.81 E-value: 8.13e-13

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157818831  759 VGRPCCACFAGDGNWYRALVKEI-LPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQP 829
Cdd:cd20423     5 PNPVCLAKYSEDGKWCRALIDNVyEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQ 76

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 66.75 E-value: 9.56e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  719 SPGEFYCHClkddALKKLDDLNKSLADYCAQKPPNGFKA---EVGRPCCACFAGDGNWYRALVKEIlPSGNVKVHFVDYG 795
Cdd:cd20426    10 SPEYFWCQF----ATEKIQCLAVKVQEAGEQVADRGNFIpsiYVGDPCIVKYSEDNHWYRALVTKI-NDNLVSVRFVDYG 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 157818831  796 NVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKHWTKEATARF 842
Cdd:cd20426    85 NEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYF 131

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 63.30 E-value: 1.31e-12

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 157818831  987 GEACCAKYTNDDFWYRAIVLEASDSD-VKVLYADYGNVERLPFSRVQPI 1034
Cdd:cd20379     2 GDLCAAKYEEDGKWYRARVLEVLSNDkVEVFFVDYGNTETVPLSDLRPL 50

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 64.04 E-value: 1.38e-12

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157818831  312 VCVAKYTVDQTWNRAVVEGVDVLQKKAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAG 383
Cdd:cd20423     8 VCLAKYSEDGKWCRALIDNVYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSG 79

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 62.92 E-value: 1.77e-12

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 157818831  309 KGEVCVAKYTVDQTWNRAVVEGVDvLQKKAHVLYIDYGNEEIIPVDRIHQL 359
Cdd:cd20379     1 VGDLCAAKYEEDGKWYRARVLEVL-SNDKVEVFFVDYGNTETVPLSDLRPL 50

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 65.57 E-value: 2.08e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  492 GVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCSHVTPRSDFY--PTIGDMCCAQFSEDDQWYRAsVLAYASEESVLVG 569
Cdd:cd20438     9 AFVEYVLNPSNFWIRTDEYNNEFQALMKNIADIYNLCGNDEELLkkPEPGLLCCARYSKDRHYYRA-VITEVLDLKVSVY 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 157818831  570 YVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGMWTPEAICVMRK 623
Cdd:cd20438    88 FLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWTKNANDFFKK 141

MYND finger;

Pssm-ID: 460312 Cd Length: 39 Bit Score: 62.05 E-value: 2.79e-12

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 157818831   162 CHRCGLFGS--LRCSQCKQTYYCSTACQRRDWSSHSTIC 198
Cdd:pfam01753    1 CAVCGKEALklLRCSRCKSVYYCSKECQKADWPYHKKEC 39

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 62.36 E-value: 3.08e-12

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 157818831  982 YRPRTGEACCAKYTNDDFWYRAIVLEASDSD-VKVLYADYGNVERLPFSRVQPITASHL 1039
Cdd:cd20410     1 FKPIVGEPCCAFFSGDGNWYRAMVKEILPGGaVKVHFVDYGNVEEVTLDKLRKITSTFL 59

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 64.75 E-value: 3.51e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  703 EFTVDETVDVMVCMMHSPGEFYCH--CLKddalKKLDDLNKSLADYCAQKPPNGFKA---EVGRPCCACfAGDGNWYRAL 777
Cdd:cd20421     6 QLQVGVTETVVVTEVTDPHRIFCQlrSLS----QELKRLSESMHQYYEGRVGSGYETrpeKLGSPCAAR-GSDGRWYRAV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 157818831  778 VKEILPSGN-VKVHFVDYGNVEEVTTDQLHAIAPQFLLLP 816
Cdd:cd20421    81 LQQVFSANRvVEVLHVDYGRKEVVSVSNLRYLAPEYFRMP 120

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 64.45 E-value: 3.67e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  484 LNVGDEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCSHVTP-RSDFYPtiGDMCCAQFSeDDQWYRASVLayAS 562
Cdd:cd20424     8 IKIGSEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRLSSEIRKlELSVNP--GTLCLAKYS-DQHWYRGIII--TN 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 157818831  563 EESVLVGYVDYGNFEILSLKRLCPI---IPKLLDLPMQALNCVL 603
Cdd:cd20424    83 KNSTEVFFVDYGNTEKVEKEDMLPIpsdAYELLLLPMQAIKCSL 126

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 63.61 E-value: 4.61e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  500 PEDFFCQQLQSGHKLAELQESLSEYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEIL 579
Cdd:cd20441     2 PSRFFIQLSEDEKVILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGNTAVV 81

                          90       100
                  ....*....|....*....|....*..
gi 157818831  580 SLKRLCPIIPKLLDLPMQALNCVLAGV 606
Cdd:cd20441    82 DKSNIYTLQEKFLSLPRLSIPCSLSGV 108

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 62.88 E-value: 4.71e-12

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157818831  989 ACCAKYTNDDFWYRAIVLEASDS--DVKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEGLTELNG 1058
Cdd:cd20423     8 VCLAKYSEDGKWCRALIDNVYEPveMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSG 79

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 62.31 E-value: 5.79e-12

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157818831  517 LQESLSEYCSHVTPRSDfYPTIGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKL 591
Cdd:cd20430     1 LSDELAEVCPTAPPLFG-TPDPNKIYGGKFSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETVSRSSIVELPPDL 74

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 62.84 E-value: 8.68e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  719 SPGEFYCHCLKDDA--LKKLDDLNkSLADYCAQKPPNgfKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGN 796
Cdd:cd20441     1 SPSRFFIQLSEDEKviLQLAEELN-ETSEKSRENAAV--KLKVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGN 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 157818831  797 VEEVTTDQLHAIAPQFLLLPFQGMQCWLVDI 827
Cdd:cd20441    78 TAVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 61.07 E-value: 1.48e-11

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157818831  763 CCACFAGDGnWYRALVKEILPSGN-VKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQP 829
Cdd:cd20407    10 ICAAPVMNA-WYRAQVVGVFEETDeVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 62.48 E-value: 1.51e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  980 PPYRPRTGEACCAKYTNDDFWYRAIVLEA-------SDSDVKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEG 1052
Cdd:cd20443    34 GGFNPKKGELVLAQFSADNSWNRAMVVNAprqgtqsPKDEYEVFYIDYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAH 113


                  .
gi 157818831 1053 L 1053
Cdd:cd20443   114 I 114

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 62.91 E-value: 1.56e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  711 DVMVCMMHSPGEFYCHCLKDDALkkLDDLNKSLADYCAQKPPNGFKAEVGRPCCACFAgDGNWYRALVKEILPsgNVKVH 790
Cdd:cd20424    15 EVYITYVNDPWTFYCQLARNAGV--LDQLASAISRLSSEIRKLELSVNPGTLCLAKYS-DQHWYRGIIITNKN--STEVF 89

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 157818831  791 FVDYGNVEEVTTDQLHAI---APQFLLLPFQGMQCWL 824
Cdd:cd20424    90 FVDYGNTEKVEKEDMLPIpsdAYELLLLPMQAIKCSL 126

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 62.90 E-value: 1.84e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  949 YAIPSEMPE---------NQEKLCVLTAELLEHcNAQKGQPPYRPRTGEACCAKYTNDDFWYRAIVLEASDSDVKVLYAD 1019
Cdd:cd20426     4 YATAVDSPEyfwcqfateKIQCLAVKVQEAGEQ-VADRGNFIPSIYVGDPCIVKYSEDNHWYRALVTKINDNLVSVRFVD 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 157818831 1020 YGNVERLPFSRVQPITASHLQLPFRIIRCSLEGLTELNGSSSQ 1062
Cdd:cd20426    83 YGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSD 125

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 60.93 E-value: 1.87e-11

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157818831  285 MNQLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEGVdVLQKKAHVLYIDYGNEEIIPVDRIHQLSRSI 363
Cdd:cd20409     4 LAELQESLSAYCKVAPASSDFSPAVGEVCCAQFTEDNQWYRASVLAY-SSEDSVLVGYIDFGNSEEVALSRLRPIPPSL 81

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 61.29 E-value: 2.25e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  517 LQESLSEYCSH-VTPRSDFYPTIGDMCCAQfSEDDQWYRASVLAyASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLP 595
Cdd:cd20427     3 MEDEMKEFYSKsSTAMCLRSPSVGQLVAVK-AEEDAWLRAQVIE-VEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLP 80

                          90
                  ....*....|...
gi 157818831  596 MQALNCVLAGVKP 608
Cdd:cd20427    81 FQATKCKLAGLEP 93

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 57.28 E-value: 2.17e-10

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 157818831    536 PTIGDMCCAQFsEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKL 591
Cdd:smart00333    3 FKVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 59.43 E-value: 2.24e-10

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157818831  981 PYRPrtGE-ACCAKYTNDDFWYRAIVL-EASDSDVKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEGL 1053
Cdd:cd20439    53 PYKH--GQiACVAKYSKDGKWYRAAVLkQVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 59.00 E-value: 2.64e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  939 VLEIISPTLFYAIPSEmPENQEKLCVLTAELLEHCNAQKGQPPYRP-----RTGEACCAKYTNDDFWYRAIVLEASDSD- 1012
Cdd:cd20419     2 VEYIESPSQFYVRFYS-KDTSEMLEDMMIEMRRCYSNEHVSERYVMpeafiQPGQVCCVRIPEDVWWYRVIIHQVLNKQe 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 157818831 1013 VKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSL 1050
Cdd:cd20419    81 VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 57.30 E-value: 3.57e-10

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157818831  742 SLADYCAQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQF 812
Cdd:cd20430     4 ELAEVCPTAPPLFGTPDPNKIYGGKFSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETVSRSSIVELPPDL 74

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 59.02 E-value: 4.04e-10

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157818831  983 RPRTGEACCAKYTNDDFWYRAIVLEASDSDVKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSL 1050
Cdd:cd20438    54 KPEPGLLCCARYSKDRHYYRAVITEVLDLKVSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSL 121

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 56.51 E-value: 4.39e-10

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 157818831    758 EVGRPCCACFaGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQF 812
Cdd:smart00333    4 KVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 59.28 E-value: 5.21e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  260 KGTVTEFKHPGHFYVQLY-SSEVLEYMNQLSASLKETYANMVPEDgylPVKGEVCVAKYTVDQTWNRAVVEGVDVLQKKA 338
Cdd:cd20442     5 KGTLLSVSKNGTFYVRLLrNSEQLTDLESLIAKEAKKCKFVPVED---IKEGLECLAKSKKNLKWYRAVVEHLYPETEKM 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 157818831  339 HVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKC 373
Cdd:cd20442    82 LVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLC 116

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 58.59 E-value: 5.28e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  493 VVAHIQTPEDFFCQQLQSGHKLAELQESLSEY--CSHVTPRSDFYPTIGDMCCAQfSEDDQWYRASVL-AYASEESVLVG 569
Cdd:cd20421    16 VVTEVTDPHRIFCQLRSLSQELKRLSESMHQYyeGRVGSGYETRPEKLGSPCAAR-GSDGRWYRAVLQqVFSANRVVEVL 94

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 157818831  570 YVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAG 605
Cdd:cd20421    95 HVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 57.01 E-value: 7.27e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  941 EIISPTLFYAIpSEMPENQEKLCVLTAELlehcNAQKGQP-PYRPRTGEACCAKYTNDDF--WYRAIVLEASDSDVKVLY 1017
Cdd:cd20431     2 EVVEVGHFWGY-RIDENSSEILQQLTAEI----NQRQLVPlTTKPVPNLLCLAPFTDADMkkYYRAKILYVSGSSAEVFF 76

                          90       100
                  ....*....|....*....|....*
gi 157818831 1018 ADYGNVERLPFSRVQPITASHLQLP 1042
Cdd:cd20431    77 VDYGNTSQVPSSLLREIPETLLTLP 101

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 56.06 E-value: 9.84e-10

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157818831  538 IGDMCCAQFseDDQWYRASVLAYASE-ESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKP 608
Cdd:cd20407     7 VGVICAAPV--MNAWYRAQVVGVFEEtDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 56.69 E-value: 1.64e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  494 VAHIQTPEDF---FCQQLQS---GHKLAELQESLS-EYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESV 566
Cdd:cd20419     2 VEYIESPSQFyvrFYSKDTSemlEDMMIEMRRCYSnEHVSERYVMPEAFIQPGQVCCVRIPEDVWWYRVIIHQVLNKQEV 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 157818831  567 LVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVL 603
Cdd:cd20419    82 EVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 56.70 E-value: 1.78e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  269 PGHFYVQLYSSEVLeyMNQLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEgvdvlQKKA----HVLYID 344
Cdd:cd20425    12 PSDFYVQLAQDEDE--LSMISEKLNASKANDEEVECESLQLGDLICAEYPEDGLWYRAVVK-----EKIPnnlvSVQFID 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 157818831  345 YGNEEIIPVDRIHQLSRSISLFPPSAIKCYV 375
Cdd:cd20425    85 YGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 56.74 E-value: 2.40e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  259 IKGTVTEFKHPGHFYVQLYSSEV--LEYMNQLSASLKETYANMVPEdgylPVKGEVCVAKYTVDQTWNRAVVEGVDvlQK 336
Cdd:cd20426     1 IEAYATAVDSPEYFWCQFATEKIqcLAVKVQEAGEQVADRGNFIPS----IYVGDPCIVKYSEDNHWYRALVTKIN--DN 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 157818831  337 KAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGEWTEDCV 390
Cdd:cd20426    75 LVSVRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEAN 128

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 55.92 E-value: 2.90e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  714 VCMMHSPGEFYCHCLKDDALKKLDDLNKSLADYCAQK------PPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGNV 787
Cdd:cd20419     2 VEYIESPSQFYVRFYSKDTSEMLEDMMIEMRRCYSNEhvseryVMPEAFIQPGQVCCVRIPEDVWWYRVIIHQVLNKQEV 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 157818831  788 KVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWL 824
Cdd:cd20419    82 EVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 56.68 E-value: 2.97e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  711 DVMVCMMHSPGEFYCHcLKDDALKKLDDLNKSLADY--CAQKPPNGFkaeVGRPCCA--C-FAGDGNWYRALVKEILPSG 785
Cdd:cd20428     3 NVRVTNVCSDGTLYCQ-VPSKGLSKLNEILDKIEYYfhSRQMTSEYF---VSLPFCGkiClARYKGKWARVEITNVHSSR 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 157818831  786 NVKVHFVDYGNVEEVTTDQLHAIAPQFL----LLPFQGMQCWLVDIQPKNKHWTKEA 838
Cdd:cd20428    79 ALDVHFLDTGTVASVKVSELREIPPPFLreliSIPPQALKCCLADLPLNIGMWTPDA 135

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 55.13 E-value: 4.05e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  944 SPTLFYAipsEMPENQEKLCVLTAELLEHCNAQKGQPPYRPRTGEACCAKYTNDDFWYRAIVLE-ASDSDVKVLYADYGN 1022
Cdd:cd20441     1 SPSRFFI---QLSEDEKVILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDEDLALYRAVITAvLPGKSFKVEFIDYGN 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 157818831 1023 VERLPFSRVQPITASHLQLPFRIIRCSLEGL 1053
Cdd:cd20441    78 TAVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 55.98 E-value: 4.47e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  260 KGTVTEFKHPGHFYVQLYSSEVLeyMNQLSASLKETYANMVPEDGYL--PVKGEVCVAKYTvDQTWNRAVVegVDVLQKK 337
Cdd:cd20422     3 DAQVEFVKDPSEFWIRLGEHAVP--FSKLMRSMTAFYSQASKLDGVVlkPQPGQLCCAKWK-EDRYYRAIV--TAVKGKM 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 157818831  338 AHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGEWTEDCVVAVK 394
Cdd:cd20422    78 VEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFK 134

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 55.98 E-value: 5.02e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  983 RPRTGEACCAKYtNDDFWYRAIVLEASDSDVKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEGLTELNGSSSQ 1062
Cdd:cd20422    49 KPQPGQLCCAKW-KEDRYYRAIVTAVKGKMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSP 127


                  ...
gi 157818831 1063 PVM 1065
Cdd:cd20422   128 EAI 130

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 54.61 E-value: 5.17e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  965 LTAELLEHCNAQKGQPPYR-PRTGEACCAKYTNDDFWYRAIVLEASDSD-VKVLYADYGNVERLPFSRVQPITASHLQLP 1042
Cdd:cd20412     9 LVQEMTQYYESEENRHTLLtVQVGDIVAAPFRHDGSWYRARVLGFLENGnLDLYFVDYGDSGYVPLEDLRALRSDFLSLP 88


                  ....*..
gi 157818831 1043 FRIIRCS 1049
Cdd:cd20412    89 FQAIECS 95

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 55.14 E-value: 8.92e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  504 FCQQLQSG-HKLAELQESLSEYCSHVTPRSDFY---PTIGDMCCAQFSedDQWYRASVLAYASEESVLVGYVDYG---NF 576
Cdd:cd20428    16 YCQVPSKGlSKLNEILDKIEYYFHSRQMTSEYFvslPFCGKICLARYK--GKWARVEITNVHSSRALDVHFLDTGtvaSV 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 157818831  577 EILSLKRLCPIIPK-LLDLPMQALNCVLAGVKPSLGMWTPEAICVMR 622
Cdd:cd20428    94 KVSELREIPPPFLReLISIPPQALKCCLADLPLNIGMWTPDAVLWLR 140

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 52.28 E-value: 1.21e-08

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 157818831    307 PVKGEVCVAKYTvDQTWNRAVVEGVDVlQKKAHVLYIDYGNEEIIPVDRIHQL 359
Cdd:smart00333    3 FKVGDKVAARWE-DGEWYRARIVKVDG-EQLYEVFFIDYGNEEVVPPSDLRQL 53

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 53.59 E-value: 1.33e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157818831  759 VGRPCCACFAgDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQP 829
Cdd:cd20415    27 QGQACVALFE-DGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410500 Cd Length: 91 Bit Score: 53.26 E-value: 1.35e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 157818831  770 DGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGM 820
Cdd:cd20429    41 ENNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLIEKFRQLPFQAI 91

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 53.58 E-value: 1.87e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  943 ISPTLFYAipsEMPENQEKLCVLTAELLEHCNA-QKGQPPYRPRTGEACCAKyTNDDFWYRAIVLEA-SDSDVKVLYADY 1020
Cdd:cd20437    13 VSPSKFYC---QLLSWEPELSKLTTQMTLHYESvSKELNPSCENFGLLCAAK-GKDGQWHRGFLQQLlPPSQVKVWFIDY 88

                          90       100       110
                  ....*....|....*....|....*....|
gi 157818831 1021 GNVERLPFSRVQPITASHLQLPFRIIRCSL 1050
Cdd:cd20437    89 GNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 53.21 E-value: 1.94e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  269 PGHFYVQLYSSE-----VLEYMNQLSASLKETYANMvpedgylPVKGEVCVAKYTVDQTWNRAVVEgvDVL-QKKAHVLY 342
Cdd:cd20441     2 PSRFFIQLSEDEkvilqLAEELNETSEKSRENAAVK-------LKVGDLVAAEYDEDLALYRAVIT--AVLpGKSFKVEF 72

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 157818831  343 IDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGV 378
Cdd:cd20441    73 IDYGNTAVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 53.61 E-value: 2.66e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  939 VLEIISPTLFYAIPSEMPENQEKLCVLTAELLEHCNAQKgqppYRPRTGEACCAKYTNDDFWYRAIVLEA-SDSDVKVLY 1017
Cdd:cd20440    16 ITHVYSPAKFYCQLDRNTEILEALMEKIAEISKLFNSQI----LDNCKTRLCLAKYFEDGQWYRALAHPVeSSSHLSVYF 91

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 157818831 1018 ADYGNVERLPFSRVQPI--TASHLQL-PFRIIRCSL 1050
Cdd:cd20440    92 VDYGNKQIVEKNEVLPIpdTAVDLLLtPMQAIKCCL 127

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 53.19 E-value: 3.07e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  491 CGVVAHIQ-----TPEDFFCQQLQSGHKLAELQESLSEYCSHVTPRSDfyPTI---GDMCCAQfSEDDQWYRASVLAYAS 562
Cdd:cd20437     1 VGTTEKVKitaavSPSKFYCQLLSWEPELSKLTTQMTLHYESVSKELN--PSCenfGLLCAAK-GKDGQWHRGFLQQLLP 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 157818831  563 EESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLA 604
Cdd:cd20437    78 PSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLS 119

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 53.02 E-value: 5.05e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157818831  764 CACFAGDGNWYRALVKEILPSG------NVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQP--KNKHW 834
Cdd:cd20435    56 CAVEDENNLYHRVKVLEITEKDdktkprEVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKPvdNDTEW 134

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 51.67 E-value: 5.25e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  982 YRPRTGEACCAKYtNDDFWYRA-IVLEASDSDVKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSL 1050
Cdd:cd20415    23 LCPVQGQACVALF-EDGAWYRArIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRL 91

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 50.42 E-value: 5.72e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 157818831  305 YLPVKGEVCVAKYTVDQTWNRAVVEgvDVLQK-KAHVLYIDYGNEEIIPVDRIHQLS 360
Cdd:cd20410     1 FKPIVGEPCCAFFSGDGNWYRAMVK--EILPGgAVKVHFVDYGNVEEVTLDKLRKIT 55

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 52.64 E-value: 6.13e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157818831  536 PTIGDMCCAQfSEDDQWYRASVLAYASEES------VLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKP 608
Cdd:cd20435    50 VKVGDLCAVE-DENNLYHRVKVLEITEKDDktkpreVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKP 127

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 52.86 E-value: 6.75e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  269 PGHFYVQlysseVLEYMNQLSASLK---ETYANMVPEDGYL--PVKGEVCVAKYTVDQTWNRAVVegVDVLQKKAHVLYI 343
Cdd:cd20438    17 PSNFWIR-----TDEYNNEFQALMKniaDIYNLCGNDEELLkkPEPGLLCCARYSKDRHYYRAVI--TEVLDLKVSVYFL 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 157818831  344 DYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGEWTE 387
Cdd:cd20438    90 DFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWTK 133

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.

Pssm-ID: 410469 Cd Length: 56 Bit Score: 49.96 E-value: 8.55e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 157818831  538 IGDMCCAQFSEDDQWYRASVLA-YASEESVLVGYVDYGNFEILSLKRLCPIIPK 590
Cdd:cd20398     3 VGDKCRAVYSEDGIIYEATIVSiDAERGTCVVRYTGYGNEEEQNLSDLLPPSGE 56

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 49.56 E-value: 9.79e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 157818831  310 GEVCVAKYTVDQTWNRAVVEGVDVLQKKAHVLYIDYGNEEIIPVDRIHQL 359
Cdd:cd21182     1 GDKCLAPYSDDGKYYEATIEEITEESDTATVVFDGYGNSEEVPLSDLKPL 50

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 51.30 E-value: 1.18e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  263 VTEFKHPGHFYVQLYSSEVLEYMNQLSASLKETYANMVPEDGY-LP----VKGEVCVAKYTVDQTWNRAVVegVDVL-QK 336
Cdd:cd20419     2 VEYIESPSQFYVRFYSKDTSEMLEDMMIEMRRCYSNEHVSERYvMPeafiQPGQVCCVRIPEDVWWYRVII--HQVLnKQ 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 157818831  337 KAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKC 373
Cdd:cd20419    80 EVEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPA 116

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 49.12 E-value: 1.31e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 157818831  987 GEACCAKYTNDDFWYRAIVLEASDSD-VKVLYaDYGNVERLPFSRVQP 1033
Cdd:cd04508     1 GDRVEAKWSDDGQWYPATVVAVNDDGkYTVLF-DDGNEEEVSEDDIRP 47

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 52.35 E-value: 1.37e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  513 KLAELQESLSEYCSHV---TPRSDFYPTI----GDMCCAQFSEDDQWYRASVL-AYASEESVLVGYVDYGNFEILSL--- 581
Cdd:cd20442    20 RLLRNSEQLTDLESLIakeAKKCKFVPVEdikeGLECLAKSKKNLKWYRAVVEhLYPETEKMLVFFVDHGITEVVSMgni 99

                          90       100
                  ....*....|....*....|
gi 157818831  582 KRLCpiiPKLLDLPMQALNC 601
Cdd:cd20442   100 KQLS---NDLLQIPRQAVLC 116

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 51.26 E-value: 1.43e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  261 GTVTEFK-----HPGHFYVQLYSSEV-LEYMNQLSASLKETYAN-MVPEDGYLpvkGEVCVAKYTvDQTWNRAVVEGVdV 333
Cdd:cd20437     2 GTTEKVKitaavSPSKFYCQLLSWEPeLSKLTTQMTLHYESVSKeLNPSCENF---GLLCAAKGK-DGQWHRGFLQQL-L 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 157818831  334 LQKKAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVS 376
Cdd:cd20437    77 PPSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLS 119

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 48.79 E-value: 1.68e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 157818831  539 GDMCCAQFSEDDQWYRASVLA-YASEESVLVGYVDYGNFEILSLKRLCPI 587
Cdd:cd21182     1 GDKCLAPYSDDGKYYEATIEEiTEESDTATVVFDGYGNSEEVPLSDLKPL 50

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 50.54 E-value: 2.67e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  721 GEFYchcLKDDALKKLDDLNKSLADYCAQK---PPNGFKAEVGRPCCACFAGDGNWYRALVKE------ILPSGNVKVHF 791
Cdd:cd20443     2 GRFY---VQVVSDQRLSSIQQQLEGLSLKDkanPPGGFNPKKGELVLAQFSADNSWNRAMVVNaprqgtQSPKDEYEVFY 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 157818831  792 VDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQP 829
Cdd:cd20443    79 IDYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 49.33 E-value: 4.27e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157818831  761 RPCCACFA--GDGNWYRALVKEILPSGNVK--VHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKN 831
Cdd:cd20418     5 RPEMPCLAeySDGKWYRAKLLSILEFNPVKilVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPL 79

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 47.30 E-value: 6.31e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 157818831  307 PVKGEVCVAKYtvDQTWNRAVVEGVDVLQKKAHVLYIDYGNEEIIPVDRIHQLS 360
Cdd:cd20444     1 PTPGQMVIAKF--DGNHYRAIVLRVLNPDLKILVRFVDFGNVEVMKLENLYECP 52

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 49.41 E-value: 8.00e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  261 GTVTEFK-----HPGHFYVQLY--SSEVLEYMNQLSaSLKETYANMvpedgYLPvkGEV-CVAKYTVDQTWNRAVVEGVd 332
Cdd:cd20439     9 GSVVDVKcsyvnSPGDFWCQLQtkSSELKSLMKQIQ-SYYLIHNDP-----YKH--GQIaCVAKYSKDGKWYRAAVLKQ- 79

                          90
                  ....*....|....*..
gi 157818831  333 VLQKKAHVLYIDYGNEE 349
Cdd:cd20439    80 VSAKEVDVIFVDYGNQE 96

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 48.56 E-value: 9.76e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157818831  985 RTGEACCAKYtNDDFWYRAIVLEASD-SDVKVL--YADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEGLTELNGSS 1060
Cdd:cd20418     5 RPEMPCLAEY-SDGKWYRAKLLSILEfNPVKILvrHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPLNDS 82

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 49.04 E-value: 9.83e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  263 VTEFKHPGHFYVQL-YSSEVLEYMNQLSASLKETYANMVpedgyLPVK-GEVCVAKYTvDQTWNRAVVegvDVLQKKAHV 340
Cdd:cd20424    18 ITYVNDPWTFYCQLaRNAGVLDQLASAISRLSSEIRKLE-----LSVNpGTLCLAKYS-DQHWYRGII---ITNKNSTEV 88

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 157818831  341 LYIDYGNEEIIPVDRIHQL---SRSISLFPPSAIKC 373
Cdd:cd20424    89 FFVDYGNTEKVEKEDMLPIpsdAYELLLLPMQAIKC 124

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 47.29 E-value: 1.04e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 157818831  307 PVKGEVCVAKYTVDQTWNRAVVEGVDVlQKKAHVLYIDYGNEEIIPVDRIHQLS 360
Cdd:cd20430    19 PDPNKIYGGKFSEDNCWYRCKVKSILS-DEKCTVQYIDYGNTETVSRSSIVELP 71

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 48.96 E-value: 1.09e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  262 TVTEFKHPGHFYVQL--YSSEVleymNQLSASLKETY-ANMVPEDGYLPVK-GEVCVAKyTVDQTWNRAVVEGVDVLQKK 337
Cdd:cd20421    16 VVTEVTDPHRIFCQLrsLSQEL----KRLSESMHQYYeGRVGSGYETRPEKlGSPCAAR-GSDGRWYRAVLQQVFSANRV 90

                          90       100
                  ....*....|....*....|...
gi 157818831  338 AHVLYIDYGNEEIIPVDRIHQLS 360
Cdd:cd20421    91 VEVLHVDYGRKEVVSVSNLRYLA 113

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 48.65 E-value: 1.22e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  942 IISPTLFYAipsEMPENQEKLCVLTAELLEHCNA-QKGQPPYRPrtGEACCAKYTnDDFWYRAIVLEASDSdVKVLYADY 1020
Cdd:cd20424    21 VNDPWTFYC---QLARNAGVLDQLASAISRLSSEiRKLELSVNP--GTLCLAKYS-DQHWYRGIIITNKNS-TEVFFVDY 93

                          90       100       110
                  ....*....|....*....|....*....|...
gi 157818831 1021 GNVERLPFSRVQPITASH---LQLPFRIIRCSL 1050
Cdd:cd20424    94 GNTEKVEKEDMLPIPSDAyelLLLPMQAIKCSL 126

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410470 [Multi-domain] Cd Length: 55 Bit Score: 46.53 E-value: 1.36e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 157818831  759 VGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQL 805
Cdd:cd20399     3 VGDKCMAVWSEDGQYYEATIEEISEDGTCTVTFDGYGNTEVTPLSQL 49

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 46.09 E-value: 1.60e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 157818831  760 GRPCCACFAGDGNWYRALVKEILPSGN-VKVHFVDYGNVEEVTTDQLHAI 808
Cdd:cd21182     1 GDKCLAPYSDDGKYYEATIEEITEESDtATVVFDGYGNSEEVPLSDLKPL 50

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 47.42 E-value: 1.72e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157818831  765 ACFAGDGNWYRALVKEIlPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQP 829
Cdd:cd20427    30 AVKAEEDAWLRAQVIEV-EEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQATKCKLAGLEP 93

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 45.76 E-value: 2.22e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 157818831  536 PTIGDMCCAQFseDDQWYRASVL-AYASEESVLVGYVDYGNFEILSLKRL--CP 586
Cdd:cd20444     1 PTPGQMVIAKF--DGNHYRAIVLrVLNPDLKILVRFVDFGNVEVMKLENLyeCP 52

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 47.45 E-value: 2.46e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  939 VLEIISPTLFYAipsEMPENQEKLCVLTAELlehcNAQKGQPPYRP----RTGEACCAKYTNDDFWYRAIVLEASDSD-V 1013
Cdd:cd20425     6 VSHVNSPSDFYV---QLAQDEDELSMISEKL----NASKANDEEVEceslQLGDLICAEYPEDGLWYRAVVKEKIPNNlV 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 157818831 1014 KVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSL 1050
Cdd:cd20425    79 SVQFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 47.07 E-value: 4.34e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  263 VTEFKHPGHFYVQLYSSEvlEYMNQLSASLKEtYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEGVDVLQkKAHVLY 342
Cdd:cd20440    16 ITHVYSPAKFYCQLDRNT--EILEALMEKIAE-ISKLFNSQILDNCKTRLCLAKYFEDGQWYRALAHPVESSS-HLSVYF 91

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 157818831  343 IDYGNEEIIPVDR---IHQLSRSISLFPPSAIKCY 374
Cdd:cd20440    92 VDYGNKQIVEKNEvlpIPDTAVDLLLTPMQAIKCC 126

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 47.25 E-value: 4.97e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  268 HPGHFYVQL-----YSSEVLEYMN----QLSASLKETYA---NMVPEDgyLPVKGEVCVAKYTvDQTWNRAVVEGV---- 331
Cdd:cd20435     1 DATHYSARIlehrsSDGEVTKSMSstylKLSMKLNMYYSdpsNRILHG--KVKVGDLCAVEDE-NNLYHRVKVLEItekd 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 157818831  332 -DVLQKKAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVP 380
Cdd:cd20435    78 dKTKPREVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKP 127

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 46.23 E-value: 5.18e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  496 HIQTPEDFFCQQ--LQSGHKLAELQESLSEYcSHVTPRSDFYPTigDMCCAQFSEDDQ--WYRASVLaYASEESVLVGYV 571
Cdd:cd20431     2 EVVEVGHFWGYRidENSSEILQQLTAEINQR-QLVPLTTKPVPN--LLCLAPFTDADMkkYYRAKIL-YVSGSSAEVFFV 77

                          90       100
                  ....*....|....*....|....
gi 157818831  572 DYGNFEILSLKRLCPIIPKLLDLP 595
Cdd:cd20431    78 DYGNTSQVPSSLLREIPETLLTLP 101

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 45.28 E-value: 6.50e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157818831  989 ACCAKYTNDDfWYRAIVLEASDSD--VKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEGLT 1054
Cdd:cd20407     9 VICAAPVMNA-WYRAQVVGVFEETdeVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIE 75

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 44.16 E-value: 6.71e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 157818831  987 GEACCAKYTNDDFWYRAIVLE--ASDSDVKVLYADYGNVERLPFSRVQPI 1034
Cdd:cd21182     1 GDKCLAPYSDDGKYYEATIEEitEESDTATVVFDGYGNSEEVPLSDLKPL 50

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 44.57 E-value: 7.02e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 157818831    987 GEACCAKYtNDDFWYRAIVLEASDSD-VKVLYADYGNVERLPFSRVQPI 1034
Cdd:smart00333    6 GDKVAARW-EDGEWYRARIVKVDGEQlYEVFFIDYGNEEVVPPSDLRQL 53

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 46.65 E-value: 7.66e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  928 ELPVNKTVPANVLEIISPTLFYA-IPSEMPENQEklcvLTAELLEHCNAQKGQPPY-RPRTGEACCAKYTNDDFWYRAIV 1005
Cdd:cd20421     6 QLQVGVTETVVVTEVTDPHRIFCqLRSLSQELKR----LSESMHQYYEGRVGSGYEtRPEKLGSPCAARGSDGRWYRAVL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 157818831 1006 LE--ASDSDVKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEG 1052
Cdd:cd20421    82 QQvfSANRVVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 45.50 E-value: 8.83e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  968 ELLEHCNAQKGQPPYR-PRTGEACCAKyTNDDFWYRAIVLEASDSDVKVLYADYGNVERLPFSRVQPITASHLQLPFRII 1046
Cdd:cd20427     6 EMKEFYSKSSTAMCLRsPSVGQLVAVK-AEEDAWLRAQVIEVEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQAT 84


                  ....*..
gi 157818831 1047 RCSLEGL 1053
Cdd:cd20427    85 KCKLAGL 91

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 45.07 E-value: 1.23e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157818831  751 PPNGFkaevgrpCCACFA-GDGN-WYRALVKEILPSgNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLP 816
Cdd:cd20431    42 VPNLL-------CLAPFTdADMKkYYRAKILYVSGS-SAEVFFVDYGNTSQVPSSLLREIPETLLTLP 101

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 45.12 E-value: 1.27e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157818831  305 YLPVKGEVCVAKYTvDQTWNRAVVEGVdVLQKKAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKC 373
Cdd:cd20415    23 LCPVQGQACVALFE-DGAWYRARIIGL-PGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKAREC 89

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 42.96 E-value: 1.62e-05

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 157818831  767 FAGDGNWYRALVKEILPSGNVKVHFvDYGNVEEVTTDQL 805
Cdd:cd04508     8 WSDDGQWYPATVVAVNDDGKYTVLF-DDGNEEEVSEDDI 45

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 43.10 E-value: 1.75e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 157818831  759 VGRPCCACFAGDGNWYRALVKEILPSGNVK-VHFVDYGNVEEV 800
Cdd:cd20413     3 PGDECLAKYWEDNKFYRAEVTAVHPSGKTAvVKFMEYGNYEEV 45

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410488 Cd Length: 68 Bit Score: 43.58 E-value: 1.87e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 157818831  987 GEACCAKYTnDDFWYRAIVLEASDSDVKVLYADYGNVERLPFSRVQPI 1034
Cdd:cd20417     4 GEGCVVRGS-DTLWYRGKVLEVIGGMVRVQYVDQGYIEKIPQCHLYPM 50

Tudor domain found in Tudor domain-containing protein 10 (TDRD10) and similar proteins; TDRD10 is widely expressed and localized both to the nucleus and cytoplasm, and may play general roles like regulation of RNA metabolism. It contains a Tudor domain and an RNA recognition motif (RRM). The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410503 Cd Length: 139 Bit Score: 45.50 E-value: 2.31e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  245 FSDLRSLQLrkSMEIKGT----VTE-FKHPGHFYVQLYSSEVLEYMNQLSASLketyANMVPEDGYLP----VKGEVCVA 315
Cdd:cd20432     6 FGDLSWLAS--IMKVHGEvgllVTDtFPHTPYFWAILLTEESQQNMQQLFSTL----AEVESQQPFLAkedvHRGRRCLA 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 157818831  316 KYTVDQ---TWNRAVVegVDVLQKKAHVLYIDYGNEEIIPVDRIHQLS 360
Cdd:cd20432    80 ECPLGEeggAWNRCWV--LDVVEDFAVVFFVDFGSTANIPLPSLRSLD 125

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 43.94 E-value: 3.14e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157818831  313 CVAKYTvDQTWNRAVVEGVDVLQK-KAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGE 384
Cdd:cd20418    10 CLAEYS-DGKWYRAKLLSILEFNPvKILVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPLND 81

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 45.10 E-value: 3.56e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  310 GEVCVAKYTVDQTWNRAVVegVDVLQKKAHVLYIDYGNEEIipVDRIHQLSRSISLF--PPSAIKCYVSGVVPAAGEWTE 387
Cdd:cd20436    50 GEFCLVEDTTSGEWYRGRV--LEKIDEKYEVFLIDRGEVLN--VHATNMASASGELFqlPPKAVCGIFANILPIGEKWSS 125

                          90
                  ....*....|....*
gi 157818831  388 DCVVAVKALLFEQYC 402
Cdd:cd20436   126 TAVNYFSSLIGSQVK 140

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 45.10 E-value: 3.66e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  538 IGDMCCAQFSEDDQWYRASVLAyASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGMWTPEA 617
Cdd:cd20436    49 VGEFCLVEDTTSGEWYRGRVLE-KIDEKYEVFLIDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIGEKWSSTA 127


                  .
gi 157818831  618 I 618
Cdd:cd20436   128 V 128

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 43.53 E-value: 4.50e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  264 TEFKHPGHFYVQLYSSEVLEYMNQLSASLKE-TYANMVPEdgylPVKGEVCVAKYT--VDQTWNRAVVegVDVLQKKAHV 340
Cdd:cd20431     1 TEVVEVGHFWGYRIDENSSEILQQLTAEINQrQLVPLTTK----PVPNLLCLAPFTdaDMKKYYRAKI--LYVSGSSAEV 74

                          90
                  ....*....|...
gi 157818831  341 LYIDYGNEEIIPV 353
Cdd:cd20431    75 FFVDYGNTSQVPS 87

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410470 [Multi-domain] Cd Length: 55 Bit Score: 41.91 E-value: 4.51e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 157818831  537 TIGDMCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCP 586
Cdd:cd20399     2 KVGDKCMAVWSEDGQYYEATIEEISEDGTCTVTFDGYGNTEVTPLSQLKP 51

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 42.28 E-value: 6.79e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157818831  965 LTAELLEHCnaQKGQPPYR-PRTGEACCAKYTNDDFWYRAIVLEA-SDSDVKVLYADYGNVE 1024
Cdd:cd20430     1 LSDELAEVC--PTAPPLFGtPDPNKIYGGKFSEDNCWYRCKVKSIlSDEKCTVQYIDYGNTE 60

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 41.56 E-value: 6.91e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 157818831  309 KGEVCVAKYTVDQTWNRAVVEGVDVLQKKAHVLYIDYGNEEIIPVDRIHQL 359
Cdd:cd20413     3 PGDECLAKYWEDNKFYRAEVTAVHPSGKTAVVKFMEYGNYEEVLLSDIKPI 53

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 44.26 E-value: 9.48e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  958 NQEKLCVLTAELLEHCNAQKGQPPYRPRTGEACCAKYTNDDFWYRAIVLEASDSDVK--VLYADYGNVERLPFSRVQPIT 1035
Cdd:cd20442    24 NSEQLTDLESLIAKEAKKCKFVPVEDIKEGLECLAKSKKNLKWYRAVVEHLYPETEKmlVFFVDHGITEVVSMGNIKQLS 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 157818831 1036 ASHLQLPFRIIRCSLEGLTELNGSSSqpvmELLRNAMLNQSVAL 1079
Cdd:cd20442   104 NDLLQIPRQAVLCRWNWPESSKELSF----EILWKSLAGKEVKL 143

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410455 Cd Length: 55 Bit Score: 41.06 E-value: 1.12e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 157818831  764 CACFA--GDGNWYRALVKEILPSGNVKVHFVDYGNVEEVttdQLHAIAP 810
Cdd:cd20384     9 SRCLAkyDDGLWYPATVTDIDEDGKYTVKFDSYGEVAVV---ELDDILP 54

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 41.42 E-value: 1.29e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157818831  310 GEVCVAkyTVDQTWNRAVVEGVDVLQKKAHVLYIDYGNEEIIPVDRIHQLsRSISL-FPPSAIKCYVSGVVP 380
Cdd:cd20407     8 GVICAA--PVMNAWYRAQVVGVFEETDEVEIKYLDYGGYERVPVDDLRQI-RSDFMtLPFQATECYLANIEP 76

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 40.87 E-value: 1.35e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 157818831  988 EACCAKYtnDDFWYRAIVLE-ASDSDVKVLYADYGNVERLPFSRVQPIT 1035
Cdd:cd20445     3 ELCIAKY--MDKWYRAVCLEsVGDGRPTVLFCDYGNILMARLTDIRPFP 49

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 41.64 E-value: 1.74e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  287 QLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVegVDVLQKKAHVLYIDYGNEEIIPVDRIHQLSRSISLF 366
Cdd:cd20427     2 QMEDEMKEFYSKSSTAMCLRSPSVGQLVAVKAEEDAWLRAQV--IEVEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSL 79

                          90
                  ....*....|....
gi 157818831  367 PPSAIKCYVSGVVP 380
Cdd:cd20427    80 PFQATKCKLAGLEP 93

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410500 Cd Length: 91 Bit Score: 40.93 E-value: 2.72e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  961 KLCVLTAELLEHCNAQKGQPpYRPRTGEACCAKYTNDdfWYRAIVLEA-SDSDVKVLYADYGNVERLPFSRVQPITASHL 1039
Cdd:cd20429     8 KLEVLMEEMILYYNKTEERP-VAIEKNKVYAAKIENN--WYRVLVKGIlTNGLVSVYELDYGKHELVSIRKVQPLIEKFR 84


                  ....*..
gi 157818831 1040 QLPFRII 1046
Cdd:cd20429    85 QLPFQAI 91

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 42.41 E-value: 2.74e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  986 TGEACCAKYTNDDFWYRAIVLEASDSDVKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEGLTELNGSSSQPVM 1065
Cdd:cd20436    49 VGEFCLVEDTTSGEWYRGRVLEKIDEKYEVFLIDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIGEKWSSTAV 128


                  ....*.
gi 157818831 1066 ELLRNA 1071
Cdd:cd20436   129 NYFSSL 134

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 39.63 E-value: 2.76e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 157818831  539 GDMCCAQFSEDDQWYRASVLAYASEESV-LVGYVDYGNFEILSLKRLCPI 587
Cdd:cd20413     4 GDECLAKYWEDNKFYRAEVTAVHPSGKTaVVKFMEYGNYEEVLLSDIKPI 53

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 39.11 E-value: 3.59e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 157818831  539 GDMCCAQFSEDDQWYRASVLAYASEESVLVGYvDYGNFEILSLKRLCP 586
Cdd:cd04508     1 GDRVEAKWSDDGQWYPATVVAVNDDGKYTVLF-DDGNEEEVSEDDIRP 47

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 39.33 E-value: 5.04e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157818831  311 EVCVAKYtvDQTWNRAV-VEGVDvlQKKAHVLYIDYGNEEIIPVDrihqlsrSISLFPPSAIK 372
Cdd:cd20445     3 ELCIAKY--MDKWYRAVcLESVG--DGRPTVLFCDYGNILMARLT-------DIRPFPPTFAT 54

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410488 Cd Length: 68 Bit Score: 38.96 E-value: 8.77e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  764 CACFAGDGNWYRALVKEILpSGNVKVHFVDYGNVEEVTTDQLHAIA-----PQFlLLPFQ 818
Cdd:cd20417     7 CVVRGSDTLWYRGKVLEVI-GGMVRVQYVDQGYIEKIPQCHLYPMVlypdiPQF-CIPCQ 64

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410500 Cd Length: 91 Bit Score: 39.39 E-value: 9.79e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  506 QQLQSGHKLAELQESLSEYCSHVTPRSdfyPTIG--DMCCAQFseDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKR 583
Cdd:cd20429     1 QPWQELHKLEVLMEEMILYYNKTEERP---VAIEknKVYAAKI--ENNWYRVLVKGILTNGLVSVYELDYGKHELVSIRK 75

                          90
                  ....*....|....*.
gi 157818831  584 LCPIIPKLLDLPMQAL 599
Cdd:cd20429    76 VQPLIEKFRQLPFQAI 91

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 38.05 E-value: 1.07e-03

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 157818831  770 DGNWYRALVKEIL-PSGNVKVHFVDYGNVEEVTTDQL 805
Cdd:cd20444    12 DGNHYRAIVLRVLnPDLKILVRFVDFGNVEVMKLENL 48

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 37.71 E-value: 1.72e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 157818831  985 RTGEACCAKYTNDDFWYRAIV--LEASDSDVKVLYADYGNVERLPFSRVQPI 1034
Cdd:cd20413     2 KPGDECLAKYWEDNKFYRAEVtaVHPSGKTAVVKFMEYGNYEEVLLSDIKPI 53

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410455 Cd Length: 55 Bit Score: 37.59 E-value: 1.80e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 157818831  987 GEACCAKYTnDDFWYRAIVLEASDSD-VKVLYADYGNVERLPFSRVQPI 1034
Cdd:cd20384     8 GSRCLAKYD-DGLWYPATVTDIDEDGkYTVKFDSYGEVAVVELDDILPL 55

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 37.79 E-value: 1.83e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 157818831  771 GNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLP 816
Cdd:cd20445    11 DKWYRAVCLESVGDGRPTVLFCDYGNILMARLTDIRPFPPTFATEP 56

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 36.80 E-value: 3.17e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 157818831  310 GEVCVAKYTVDQTWNRAVVEGVDvLQKKAHVLYiDYGNEEIIPVDRI 356
Cdd:cd04508     1 GDRVEAKWSDDGQWYPATVVAVN-DDGKYTVLF-DDGNEEEVSEDDI 45

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 38.05 E-value: 3.81e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  288 LSASLKETYANMVPEDGYLPVK-GEVCVAKYTVDQTWNRAVVEGVdVLQKKAHVLYIDYGNEEIIPVDRIHQLsRS--IS 364
Cdd:cd20412     9 LVQEMTQYYESEENRHTLLTVQvGDIVAAPFRHDGSWYRARVLGF-LENGNLDLYFVDYGDSGYVPLEDLRAL-RSdfLS 86


                  ....*....
gi 157818831  365 LfPPSAIKC 373
Cdd:cd20412    87 L-PFQAIEC 94

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 38.19 E-value: 7.69e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  262 TVTEFKHPGHFYVQLYS------SEVLEYMNQLSASLKETYANMVPedgyLPVKGEVCVAKYTvdQTWNRavVEGVDVLQ 335
Cdd:cd20428     5 RVTNVCSDGTLYCQVPSkglsklNEILDKIEYYFHSRQMTSEYFVS----LPFCGKICLARYK--GKWAR--VEITNVHS 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818831  336 KKA-HVLYIDYGNEEIIPVDRIH----QLSRSISLFPPSAIKCYVSGVVPAAGEWTEDCV 390
Cdd:cd20428    77 SRAlDVHFLDTGTVASVKVSELReippPFLRELISIPPQALKCCLADLPLNIGMWTPDAV 136

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 35.74 E-value: 8.84e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 157818831  984 PRTGEACCAKYtnDDFWYRAIVLEASDSDVK--VLYADYGNVE 1024
Cdd:cd20444     1 PTPGQMVIAKF--DGNHYRAIVLRVLNPDLKilVRFVDFGNVE 41

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.

Pssm-ID: 410469 Cd Length: 56 Bit Score: 35.71 E-value: 9.75e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 157818831  758 EVGRPCCACFAGDGNWYRALVKEI-LPSGNVKVHFVDYGNVEEV 800
Cdd:cd20398     2 KVGDKCRAVYSEDGIIYEATIVSIdAERGTCVVRYTGYGNEEEQ 45

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410487 Cd Length: 82 Bit Score: 36.31 E-value: 9.79e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157818831  288 LSASLKETYANMVPEdgylPVKGEV---CVAKYTVDQTWNRAVVEGVdVLQKKAHVLYIDYGNEEIIPVDRIHQLSRSI 363
Cdd:cd20416     1 LQEKMIAEYENSKPE----PVKWENdmhCAVQIQDKKQWRRGQIIRV-VSDTLVEVFLYDFGNKEVVNIDCLRKLEENL 74