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Conserved domains on  [gi|157822385|ref|NP_001099844|]
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lipase member K precursor [Rattus norvegicus]

Protein Classification

lipase family protein( domain architecture ID 706631)

lipase family protein that may function as a lipase, catalyzing the hydrolysis of ester bonds of insoluble substrates such a triglycerides

EC:  3.1.1.-
Gene Ontology:  GO:0016298|GO:0016788|GO:0006629

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN02872 super family cl28691
triacylglycerol lipase
34-388 5.68e-54

triacylglycerol lipase


The actual alignment was detected with superfamily member PLN02872:

Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 183.53  E-value: 5.68e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385  34 SEIISYWGYPYERHDVVTEDGYILGTYRIPhGKGCSRKAVPKAVVYLQHGLIASASNWICNLPNNSLAFLLADSGYDVWL 113
Cdd:PLN02872  34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVS-SRNPRLGSQRGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWV 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385 114 GNSRGNTWSRKHLRLSPKSPEYWAFSLDEMAKYDLPATINLILEKSGQKqLFYVGHSQGTTIAFIAFsTNPELAKKIRMF 193
Cdd:PLN02872 113 GNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSITNSK-IFIVGHSQGTIMSLAAL-TQPNVVEMVEAA 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385 194 FALAPVVTVKYTQSPM-KKLTTLSRKAVKILFGDKMFSTHTWLEQFIATKVCNRKLfrqLCSNFLFSLSGfdpQN--LNM 270
Cdd:PLN02872 191 ALLCPISYLDHVTAPLvLRMVFMHLDQMVVAMGIHQLNFRSDVLVKLLDSICEGHM---DCNDLLTSITG---TNccFNA 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385 271 SRLDVYMAQSPAGTSVQNMLHWAQAVNSGQLQAFDWGNPdQNMMHFNQLTPPVYNISKMRVPTAMWS--GGRDVVADEKD 348
Cdd:PLN02872 265 SRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGIF-KNLKLYGQVNPPAFDLSLIPKSLPLWMgyGGTDGLADVTD 343
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 157822385 349 ---TKNLLPKVANLIYykeIPHYNHMDFYLGQDAPQEVYRDLI 388
Cdd:PLN02872 344 vehTLAELPSKPELLY---LENYGHIDFLLSTSAKEDVYNHMI 383
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
34-388 5.68e-54

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 183.53  E-value: 5.68e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385  34 SEIISYWGYPYERHDVVTEDGYILGTYRIPhGKGCSRKAVPKAVVYLQHGLIASASNWICNLPNNSLAFLLADSGYDVWL 113
Cdd:PLN02872  34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVS-SRNPRLGSQRGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWV 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385 114 GNSRGNTWSRKHLRLSPKSPEYWAFSLDEMAKYDLPATINLILEKSGQKqLFYVGHSQGTTIAFIAFsTNPELAKKIRMF 193
Cdd:PLN02872 113 GNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSITNSK-IFIVGHSQGTIMSLAAL-TQPNVVEMVEAA 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385 194 FALAPVVTVKYTQSPM-KKLTTLSRKAVKILFGDKMFSTHTWLEQFIATKVCNRKLfrqLCSNFLFSLSGfdpQN--LNM 270
Cdd:PLN02872 191 ALLCPISYLDHVTAPLvLRMVFMHLDQMVVAMGIHQLNFRSDVLVKLLDSICEGHM---DCNDLLTSITG---TNccFNA 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385 271 SRLDVYMAQSPAGTSVQNMLHWAQAVNSGQLQAFDWGNPdQNMMHFNQLTPPVYNISKMRVPTAMWS--GGRDVVADEKD 348
Cdd:PLN02872 265 SRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGIF-KNLKLYGQVNPPAFDLSLIPKSLPLWMgyGGTDGLADVTD 343
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 157822385 349 ---TKNLLPKVANLIYykeIPHYNHMDFYLGQDAPQEVYRDLI 388
Cdd:PLN02872 344 vehTLAELPSKPELLY---LENYGHIDFLLSTSAKEDVYNHMI 383
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
33-95 3.00e-29

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 108.01  E-value: 3.00e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157822385   33 ISEIISYWGYPYERHDVVTEDGYILGTYRIPHGKGCSRKAVPKAVVYLQHGLIASASNWICNL 95
Cdd:pfam04083   1 VSEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRNNSNGKGGKPVVLLQHGLLASSDNWVTNG 63
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
45-190 7.53e-07

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 49.62  E-value: 7.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385  45 ERHDVVTEDGYILGTYRIPHGKGcsrkavPKAVVYLQHGLIASASNWicnlpnNSLAFLLADSGYDVWLGNSRGntwsrk 124
Cdd:COG2267    4 RLVTLPTRDGLRLRGRRWRPAGS------PRGTVVLVHGLGEHSGRY------AELAEALAAAGYAVLAFDLRG------ 65
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157822385 125 HLRlSPKSPEYWAfSLDEMAKyDLPATINLILEKSGQKqLFYVGHSQGTTIAFIAFSTNPELAKKI 190
Cdd:COG2267   66 HGR-SDGPRGHVD-SFDDYVD-DLRAALDALRARPGLP-VVLLGHSMGGLIALLYAARYPDRVAGL 127
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
34-388 5.68e-54

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 183.53  E-value: 5.68e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385  34 SEIISYWGYPYERHDVVTEDGYILGTYRIPhGKGCSRKAVPKAVVYLQHGLIASASNWICNLPNNSLAFLLADSGYDVWL 113
Cdd:PLN02872  34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVS-SRNPRLGSQRGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWV 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385 114 GNSRGNTWSRKHLRLSPKSPEYWAFSLDEMAKYDLPATINLILEKSGQKqLFYVGHSQGTTIAFIAFsTNPELAKKIRMF 193
Cdd:PLN02872 113 GNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSITNSK-IFIVGHSQGTIMSLAAL-TQPNVVEMVEAA 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385 194 FALAPVVTVKYTQSPM-KKLTTLSRKAVKILFGDKMFSTHTWLEQFIATKVCNRKLfrqLCSNFLFSLSGfdpQN--LNM 270
Cdd:PLN02872 191 ALLCPISYLDHVTAPLvLRMVFMHLDQMVVAMGIHQLNFRSDVLVKLLDSICEGHM---DCNDLLTSITG---TNccFNA 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385 271 SRLDVYMAQSPAGTSVQNMLHWAQAVNSGQLQAFDWGNPdQNMMHFNQLTPPVYNISKMRVPTAMWS--GGRDVVADEKD 348
Cdd:PLN02872 265 SRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGIF-KNLKLYGQVNPPAFDLSLIPKSLPLWMgyGGTDGLADVTD 343
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 157822385 349 ---TKNLLPKVANLIYykeIPHYNHMDFYLGQDAPQEVYRDLI 388
Cdd:PLN02872 344 vehTLAELPSKPELLY---LENYGHIDFLLSTSAKEDVYNHMI 383
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
33-95 3.00e-29

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 108.01  E-value: 3.00e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157822385   33 ISEIISYWGYPYERHDVVTEDGYILGTYRIPHGKGCSRKAVPKAVVYLQHGLIASASNWICNL 95
Cdd:pfam04083   1 VSEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRNNSNGKGGKPVVLLQHGLLASSDNWVTNG 63
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
77-376 1.11e-22

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 95.65  E-value: 1.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385   77 VVYLQHGLIASASNWICNLPNnslaflLADSGYDVWLGNSRGNTWSRKHLRLSpkspeywAFSLDEMAKYdlpatINLIL 156
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPA------LARDGFRVIALDLRGFGKSSRPKAQD-------DYRTDDLAED-----LEYIL 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385  157 EKSGQKQLFYVGHSQGTTIAFIAFSTNPElakKIRMFFALAPVvtvkytqSPMKKLTTLSRKAVKIL--FGDKMFS--TH 232
Cdd:pfam00561  64 EALGLEKVNLVGHSMGGLIALAYAAKYPD---RVKALVLLGAL-------DPPHELDEADRFILALFpgFFDGFVAdfAP 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385  233 TWLEQFIATKVcnRKLFRQLCSNFLfslsgFDPQNLNMSRLDVYMAQSPAGTSVQNMLHWAQAVNSGQLQAFDWgnpdqn 312
Cdd:pfam00561 134 NPLGRLVAKLL--ALLLLRLRLLKA-----LPLLNKRFPSGDYALAKSLVTGALLFIETWSTELRAKFLGRLDE------ 200
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157822385  313 mmhfnqltppvyniskmrvPTAMWSGGRDVVADEK---DTKNLLPKVanliYYKEIPHYNHMDFYLG 376
Cdd:pfam00561 201 -------------------PTLIIWGDQDPLVPPQaleKLAQLFPNA----RLVVIPDAGHFAFLEG 244
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
45-190 7.53e-07

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 49.62  E-value: 7.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385  45 ERHDVVTEDGYILGTYRIPHGKGcsrkavPKAVVYLQHGLIASASNWicnlpnNSLAFLLADSGYDVWLGNSRGntwsrk 124
Cdd:COG2267    4 RLVTLPTRDGLRLRGRRWRPAGS------PRGTVVLVHGLGEHSGRY------AELAEALAAAGYAVLAFDLRG------ 65
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157822385 125 HLRlSPKSPEYWAfSLDEMAKyDLPATINLILEKSGQKqLFYVGHSQGTTIAFIAFSTNPELAKKI 190
Cdd:COG2267   66 HGR-SDGPRGHVD-SFDDYVD-DLRAALDALRARPGLP-VVLLGHSMGGLIALLYAARYPDRVAGL 127
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
78-198 3.59e-05

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 42.51  E-value: 3.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385  78 VYLQHGLIASASNWicnlpnNSLAFLLADSGYDVWlgnsrgntwsrkhlrlspkSPEYWAF--SLDEMAKYdLPATINLI 155
Cdd:COG1075    8 VVLVHGLGGSAASW------APLAPRLRAAGYPVY-------------------ALNYPSTngSIEDSAEQ-LAAFVDAV 61
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 157822385 156 LEKSGQKQLFYVGHSQGTTIAFIAFStNPELAKKIRMFFALAP 198
Cdd:COG1075   62 LAATGAEKVDLVGHSMGGLVARYYLK-RLGGAAKVARVVTLGT 103
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
43-190 4.43e-05

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 44.87  E-value: 4.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385  43 PYERHDVVTEDGYILGTYRIPHgkgcsrKAVPKAVVYLQHGLIASASNWicnlpnNSLAFLLADSGYDVWLGNSRGNTWS 122
Cdd:COG4757    6 SPESVTITAADGYPLAARLFPP------AGPPRAVVLINPATGVPQRFY------RPFARYLAERGFAVLTYDYRGIGLS 73
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157822385 123 RkhlrlsPKSPEYWAFSLDEMAKYDLPATINLILEKSGQKQLFYVGHSQGTTIafIAFSTNPELAKKI 190
Cdd:COG4757   74 R------PGSLRGFDAGYRDWGELDLPAVLDALRARFPGLPLLLVGHSLGGQL--LGLAPNAERVDRL 133
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
74-227 6.80e-04

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 41.05  E-value: 6.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822385   74 PKAVVYLQHGLiASASNWICNLpnnslAFLLADSGYDVWLGNSRGntwsrkHLRlSPKSPEYWAfSLDEMAKyDLPATIN 153
Cdd:pfam12146   3 PRAVVVLVHGL-GEHSGRYAHL-----ADALAAQGFAVYAYDHRG------HGR-SDGKRGHVP-SFDDYVD-DLDTFVD 67
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157822385  154 LILEKSGQKQLFYVGHSQGTTIAFIAFSTNPElakKIRMFFALAPVVTVK-YTQSPMKKL--TTLSRKAVKILFGDK 227
Cdd:pfam12146  68 KIREEHPGLPLFLLGHSMGGLIAALYALRYPD---KVDGLILSAPALKIKpYLAPPILKLlaKLLGKLFPRLRVPNN 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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