|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD7 |
cd17399 |
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ... |
32-445 |
1.31e-178 |
|
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340957 Cd Length: 419 Bit Score: 508.35 E-value: 1.31e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 32 RRWVFLLVVSLLSCSNAMLWLTFAPVADTIAQHFSLSMDQINWLSLIYLVLSIPFGMAAIWVLDSVGLRGATILGAWLNF 111
Cdd:cd17399 1 RRWFVLLVVCLLNCSNAMIWISFAPVADYTAEYYNVSLDAVNWLSLIYMIVSIPVGFVAMWLLDTLGLRTAIILGAWLNF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 112 SGSLLRAVPCLAVRIPS-PFAFFMSGQSLCALAQTLVISSPAKLAALWFPEHQRATANMIGTMSNPLGILIANVLSPALV 190
Cdd:cd17399 81 IGAVIRVISSLPFVDPSfRFPVLMTGQTLAAFAQPFILFLPTKLAALWFPDNQRAIANMLASMSNPLGVLLANLLSPLIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 191 KKAEDIPMMLGIYIVPAALACLLATVCLWESVPPTPPSAGAASStSESFLHGLKLLMKNKAYVILAVCFGGGIGVFSSFS 270
Cdd:cd17399 161 KSSEDIFLLLSIYTIPALIAVVLATFGVRSSVPPTPPSASAAHE-SEPFFVGLKQLFKNKQYLILMLCFGGGIGLFNALS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 271 ALLEQIFCANGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKHFTEATKIGLCLTSLTFVAFALVSQLQGQTFALAAIC 350
Cdd:cd17399 240 TLLEQILCPSGYSNNFAGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVLC 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 351 SLLGLFGFSVAPVVMELAVECSFPVGEGASAGLIFVLGQAEGVLIMLLLTAVTVR-----RTGPSFSTCRQGEDPLDWTV 425
Cdd:cd17399 320 GLFGFFGFAIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIMQALATPlsvydLPIQCASSASGNITPLDWTV 399
|
410 420
....*....|....*....|
gi 157822105 426 SLLLLAGLCTLFTCVLVIFF 445
Cdd:cd17399 400 PLLVMAGLAAVLAIIFVVFF 419
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
32-445 |
1.42e-121 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 362.49 E-value: 1.42e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 32 RRWVFLLVVSLLSCSNAMLWLTFAPVADTIAQHFSLSMDQINWLSLIYLVLSIPFGMAAIWVLDSVGLRGATILGAWLNF 111
Cdd:cd17334 1 RRWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 112 SGSLLRAVPCLAVRipsPFAFFMSGQSLCALAQTLVISSPAKLAALWFPEHQRATANMIGTMSNPLGILIANVLSPALVK 191
Cdd:cd17334 81 LGSVLKCIPLGQQP---KFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 192 KAED-IPMMLGIYIVPAALACLLATVCLWESVPPTPPSAGAASSTSE-------SFLHGLKLLMKNKAYVILAVCFGGGI 263
Cdd:cd17334 158 PPKGtKKEFGAVFYGEFGFACLLLALVLALFPPKPKYPPSAASARQQnsehvilELQKSISELLRNEPFVLLAVAFSIMM 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 264 GVFSSFSALLEQIFCANGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKHFTEATKIGLCLTSLTFVAFALVSQ---LQ 340
Cdd:cd17334 238 GVFAGFSSVLAQILLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRTRMFKLIGLIILALGTVVCTFFMLLVDrygLP 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 341 GQTFALAAICSLLGLFGFSVAPVVMELAVECSFPVGEGASAGLIFVLGQAEGVLIMLLLTAVTVrrtgpsfstcrqgedP 420
Cdd:cd17334 318 YVTLAFYLLCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLG---------------P 382
|
410 420
....*....|....*....|....*
gi 157822105 421 LDWTVSLLLLAGLCTLFTCVLVIFF 445
Cdd:cd17334 383 TPTESKYLLWFILCTVGSCLGALFF 407
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
32-402 |
1.36e-66 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 220.57 E-value: 1.36e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 32 RRWVFLLVVSLLSCSNAMLWLTFAPVADTIAQHFSLSMDQINWLSLIYLVLSIPFGMAAIWVLDSVGLRGATILGAWLNF 111
Cdd:cd17398 1 RRWIMLFLFCLYSMSNAFQWIQYAIISNIIVDYYGVSDTAVDWTSMIYMLTYIPLIFPATWLLEKYGLRVTVLLGSFLNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 112 SGSLLRavpCLAVRiPSPFAFFMSGQSLCALAQTLVISSPAKLAALWFPEHQRATANMIGTMSNPLGILIANVLSPALVK 191
Cdd:cd17398 81 LGAWLK---LFSSS-PDLFWVAMAGQTICALAQVFILGIPPRLAAVWFGPDEVSTATAIGVFGNQLGVALGFVLPPLLVP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 192 KAEDIP-----MMLGIYIVPA-ALACLLATVCLWESVPPTPPSAGAAS-----STSESFLHGLKLLMKNKAYVILAVCFG 260
Cdd:cd17398 157 NSENKDeigkgLSILFYGVAGiCTALFILVIIFFKEKPPIPPSRAQAAaqelrSEDQSYLGSLKRLFKNKGFLLLLITYG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 261 GGIGVFSSFSALLEQI---FCANGysNEFSGLCGALFIVFGILGALLLGLYVDRTKHFTEATKIGLCLTSLTFVAFAlVS 337
Cdd:cd17398 237 INTGVYYAISTLLNQMvleYFPNE--EVNAGWIGLTLVIAGLVGSVVAGIWLDKTKKYKETTIIVYILSFIGMVAFT-FT 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157822105 338 QLQGQTFALAAICSLLGLFGFSVAPVVMELAVECSFPVGEGASAGLIFVLGQAEGVLIMLLLTAV 402
Cdd:cd17398 314 LDLGSIWVVFLTAGALGFFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASAQIFGIIFTLVMGAL 378
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
32-400 |
4.03e-44 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 160.16 E-value: 4.03e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 32 RRWVFLLVVSLLSCSNAMLWLTFAPVADTIAQHFSLSMDQINWLSLIYLVLSIPFGMAAIWVLDSVGLRGATILGAWLNF 111
Cdd:cd17397 1 RRWYILLVFSLLAFTQGAVWNTWGPIADSAKPAFGWSDSDIALLANWGPIGFVPTFFFMAWLMDVKGLRIAVLSSAFLVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 112 SGSLLRAVPclavrIPSPFAFFM--SGQSLCALAQTLVISSPAKLAALWFPEHQRATANMIGTMSNPLGILIANVLSPAL 189
Cdd:cd17397 81 AGTGLRCIP-----VPNHLATWLihIGQFLNGLAGPVAMAAAPFLSATWFPPNQRATATAIASIFNYLGGAASFLIGPLV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 190 VKKAEdipmmLGIyivpaALACLLATVCLWESVPPTPPSAgAASSTSESFLHGLKLLMKNKAYVILAVCFGGGIGVFSSF 269
Cdd:cd17397 156 LMYLE-----FGW-----SALIFLAMLIYFPSKPPTPPSV-SASTQRLSYKSGILSLLKNKRFWLIALAYGIPTGVYAGW 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 270 SALLEQIFCANGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKHFTEatKIGLCLTS---LTFVAFALV--SQLQGQTF 344
Cdd:cd17397 225 SGVLDVNLTPFGVSQVEAGWIGFYSTVAGCVGGIIVGRFADRFGGRMK--LILLLLFSgatGSFLWFTLIclKLLPFSTV 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 157822105 345 ALAAICSLLGLFGFSVAPVVMELAVECSFPVGEGASAGLIFVLGQAEGVLIMLLLT 400
Cdd:cd17397 303 SLYTSCILLGVFLNGSVPLFYELAVEAAYPVPEGITSGVLTFLNNVFGLVFLLILI 358
|
|
| MFS_FLVCR1 |
cd17455 |
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ... |
32-403 |
5.91e-44 |
|
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341013 Cd Length: 407 Bit Score: 160.38 E-value: 5.91e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 32 RRWVFLLVVSLLSCSNAMLWLTFAPVADTIAQHFSLSMDQINWLSLIYLVLSIPFGMAAIWVLDSVGLRGATILGAWLNF 111
Cdd:cd17455 1 RRFAVLAVFSLYSLVNAFQWIQYSIITNIFTEFYGVSSGAIDWLSVVYMVAYVPLIFPATWLLDLKGLRVTALLGAGLNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 112 SGSLLRavpCLAVRiPSPFAFFMSGQSLCALAQTLVISSPAKLAALWFPEHQRATANMIGTMSNPLGILIANVLSPALVK 191
Cdd:cd17455 81 LGAWVK---CASVR-PDLFGVTMLAQVLCSVAQVFILGLPSRIASVWFGPREVSTACAVAVLGNQLGTAIGFLLPPVLVP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 192 KAEDIPMMLG-----IYIVPAALACLL--ATVCLWESVPPTPPSAGAA-----SSTSESFLHGLKLLMKNKAYVILAVCF 259
Cdd:cd17455 157 NTVDDIDLMGhnisiMFYGTAAVSTLLfiLTIIVFKEKPPLPPSQAQAvlqgiPSEDYSYKQSIINLFKNVPFVLLLISY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 260 GGGIGVFSSFSALLEQIFCANGYSNEF-SGLCGALFIVFGILGALLLGLYVDRTKHFTEATKIGLCLTSLTFVAFALVSQ 338
Cdd:cd17455 237 GIMTGTFYSVSTLLNQMIITHYEGEEVnAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLD 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157822105 339 LqGQTFALAAICSLLGLFGFSVAPVVMELAVECSFPVGEGASAGLIFVLGQAEGVLIMLLLTAVT 403
Cdd:cd17455 317 L-GYLIVVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIIFTLIQGKLT 380
|
|
| MFS_FLVCR2 |
cd17456 |
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ... |
32-394 |
6.54e-43 |
|
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341014 Cd Length: 406 Bit Score: 157.25 E-value: 6.54e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 32 RRWVFLLVVSLLSCSNAMLWLTFAPVADTIAQHFSLSMDQINWLSLIYLVLSIPFGMAAIWVLDSVGLRGATILGAWLNF 111
Cdd:cd17456 1 RRWVIVLLFSSYSLCNAFQWIQYGIINNIFMHFYGVSSFAIDWLSMSYMLTYIPLIFPVAWLLDKRGLRVIALVGSALNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 112 SGSLLRavpcLAVRIPSPFAFFMSGQSLCALAQTLVISSPAKLAALWFPEHQRATANMIGTMSNPLGILIANVLSPALVK 191
Cdd:cd17456 81 LGAWIK----TGSARPDLFPVTVLGQLVCSVAQVFILGMPSRIASVWFGSSEVSTACSIGVFGNQLGVAIGFLLPPVLVP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 192 KAEDIPMMLG----IYIVPAALACLL--ATVCLWESVPPTPPSAGAA-----SSTSESFLHGLKLLMKNKAYVILAVCFG 260
Cdd:cd17456 157 NIDDLDELAYhisiMFYGTAAVATLLfiLVIIVFQEKPKIPPSQAQAaiqsiPSQDYSYLQSILRLLKNVNFILLVVSYG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 261 GGIGVFSSFSALLEQIFCANGYSNEFS-GLCGALFIVFGILGALLLGLYVDRTKHFTEATKIGLCLTSLTFVAFALVSQL 339
Cdd:cd17456 237 LNTGCFYALSTLLNRMVIFHYPGEEVNaGRIGLTIVVAGMVGALISGIWLDRTKTYKQTTLAVYIMSLVGMVVYTFTLNL 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 157822105 340 qGQTFALAAICSLLGLFGFSVAPVVMELAVECSFPVGEGASAGLIFVLGQAEGVL 394
Cdd:cd17456 317 -GHLWVVFITAGTLGFFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSAQVFGII 370
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
40-411 |
5.63e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 88.64 E-value: 5.63e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 40 VSLLSCSNAMLWLTFAPVADTIAQHFSLSMDQINWLSLIYLVLSIPFGMAAIWVLDSVGLRGATILGAWLNFSGSLLRAV 119
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 120 PclavripSPFAFFMSGQSLCALAQTLVISSPAKLAALWFPEHQRATANMIGTMSNPLGILIANVLSPALVKKAEDI-PM 198
Cdd:cd06174 81 A-------PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwRA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 199 MLGIYIVPAALACLLATvcLWESVPPTPPSAGAASSTSESFLHGLKLLMKNKAYVILA-VCFGGGIGVFSSFSALLEQIF 277
Cdd:cd06174 154 VFLIAAALALLAAILLL--LVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLlAIFLVNLAYYSFSTLLPLFLL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 278 CANGYSNEFSGLCGALFIVFGILGALLLGLYVDRtkHFTEATKIGLCLTSLTFVAFALVsqLQGQTFALAAICSLLGLFG 357
Cdd:cd06174 232 DLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR--LIGRKPLLLIGLLLMALGLALLL--LAPSLLLLLLLLLLLGFGL 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 157822105 358 FSVAPVVMELAVECSFPVGEGASAGLIFVLGQAEGVLIMLLLTAVTVRRTGPSF 411
Cdd:cd06174 308 GGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTG 361
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
31-402 |
7.69e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 88.40 E-value: 7.69e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 31 ARRWVFLLVVSLLSCSNAMLWLTFAPVADTIAQHFSLSMDQINWL----SLIYLVLSIPFGMAAiwvlDSVGLRGATILG 106
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLfaipVLVGALLRIPLGFLV----DRFGPRRVLLIG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 107 AwlnfsgsLLRAVPCLAVRIPSPFAFFMSGQSLCALAQTLVISSPAKLAALWFPEHQRATANMIGTMSNPLGILIANVLS 186
Cdd:COG2223 77 L-------LLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 187 PALVkKAEDIPMMLGIYivpaALACLLATVCLWESVPPTPPSAGAASSTSesfLHGLKLLMKNKA----YVILAVCFGGG 262
Cdd:COG2223 150 PLLI-AAFGWRNAFLIL----GILLLVVAVLAWLFLRDPPAGAAAAAKAS---LRDQLEALRDPRfwllSLLYFGTFGSF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 263 IGVFSSFSALLEQIFcanGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKhfteATKIGLCLTSLTFVAFALVSQLQGQ 342
Cdd:COG2223 222 IGFSSWLPPYLVDQF---GLSAATAGLLAALFALLGALGRPLGGWLSDRIG----GRRVLLIVFALMALGLLLLALALGS 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157822105 343 TFALAAICSLLGLF-GFSVAPVVMELAVecSFPVGE-GASAGLIFVLGQAEGVLIMLLLTAV 402
Cdd:COG2223 295 LWLFLVLFLLLGLAlGGGNGAVFALVPD--IFPTKNaGAVYGLVGAAGGLGGFLGPLLFGAL 354
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
19-370 |
9.02e-18 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 85.31 E-value: 9.02e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 19 TPGDALPGPRVYARRWVFLLVVSLLSCSNAMLWLTFAPVADTIAQHFSLSMDQINWLSLIYLVLSIPFGMAAIWVLDSVG 98
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 99 LRGATILGAWLNFSGSLLRAVpclavrIPSPFAFFMsGQSLCALAQTLVISSPAKLAALWFPEHqRATANMIGTMSNPLG 178
Cdd:COG2807 82 LERTLLLALLLLAAGLLLRSL------APSVALLLA-GTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 179 ILIANVLSPALVkKAEDIPMMLGIYIVPAALACLLATVCLWESVPPTPPSAGAASSTSesflhglklLMKNKAYVILAVC 258
Cdd:COG2807 154 AALAAGLTVPLA-AALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRS---------LWRSPLAWLLTLF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 259 FGGGIGVFSSFSALLEQIFCANGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKHFTEATKIGLCLTSLTFVAFALvsq 338
Cdd:COG2807 224 FGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLL--- 300
|
330 340 350
....*....|....*....|....*....|..
gi 157822105 339 lqGQTFALAAICSLLGLFGFSVAPVVMELAVE 370
Cdd:COG2807 301 --APGSLPWLWAVLLGLGQGGLFPLALTLIGL 330
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
40-394 |
1.42e-14 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 75.15 E-value: 1.42e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 40 VSLLSCSNAMLWLTFAPV-ADTIAQHFSLSMDQINWLSLIYLVLSIPFGMAAIWVLDSVGLRGATILGAwlnfsgsLLRA 118
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGL-------LLFA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 119 VPCLAVRIPSPFAFFMSGQSLCALAQTLVISSPAKLAALWFPEHQRATANMIGTMSNPLGILIANVLSPALVkkaeDIPM 198
Cdd:pfam07690 74 LGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA----SLFG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 199 MLGIYIVPAALACLLATVCLWESVPPTPPSAGAASSTSESFLHGLKLLMKNKAYVILAVCFGGGIGVFS--SFSALLEQI 276
Cdd:pfam07690 150 WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGllTYLPLYQEV 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 277 FcanGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKHFTeaTKIGLCLTSLTFVAFALVSQLQGQTFALAAICSLLGLF 356
Cdd:pfam07690 230 L---GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRR--RLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFG 304
|
330 340 350
....*....|....*....|....*....|....*...
gi 157822105 357 GFSVAPVVMELAVECSFPVGEGASAGLIFVLGQAEGVL 394
Cdd:pfam07690 305 FGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
27-390 |
4.79e-14 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 73.47 E-value: 4.79e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 27 PRVYARRWVFLLVVSLLSCSNAMLWLTFAPVADTIAQHFSLSMDQINWLSLIYLVLSIPFGMAAIWVLDSVGLRGATILG 106
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 107 AWLNFSGSLLRAVpclavrIPSpFAFFMSGQSLCALAQTLVISSPAKLAALWFPEHQRATANMIGTMSNPLGILIANVLS 186
Cdd:COG2814 82 LLLFALGSLLCAL------APS-LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 187 PALVkKAEDIPMMLGIYIVPAALACLLATVCLWESVPPTPPSAGAAsstsesflhgLKLLMKNK----AYVILAVCFGGG 262
Cdd:COG2814 155 GLLA-DLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGS----------LRELLRRPrlllLLLLAFLLGFGF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 263 IGVFSSFSALLEQIFcanGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKHFTeATKIGLCLTSLTFVAFALVSQLqgq 342
Cdd:COG2814 224 FALFTYLPLYLQEVL---GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR-LLLIGLLLLALGLLLLALAGSL--- 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 157822105 343 tFALAAICSLLGLFGFSVAPVVMELAVECSFPVGEGASAGLIFVLGQA 390
Cdd:COG2814 297 -WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
32-408 |
4.84e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 67.20 E-value: 4.84e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 32 RRWVFLLVVSLLSCSNAMLWLTFAPVADTIAQHFSLSMDQINWLSLIYLVLSIPFGMAAIWVLDSVGLRGATILGAWLNF 111
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 112 SGSLLRAVpclavrIPSPFAFFMsGQSLCALAQTLVISSPAKLAALWFPEHQRATANMIGTMSNPLGILIANVLSPALVk 191
Cdd:COG2271 87 LATLLFGF------ATSFWQLLL-LRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLL- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 192 KAEDIPMMLGIYIVPAALACLLATVCLWesvpptppsagaasstsesflhglkllmknkayvILAVCFGGGIGVFSSFS- 270
Cdd:COG2271 159 AAFGWRAAFLILGLPGLLLALLRFWLLA----------------------------------LAYFLVYFALYGFLTWLp 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 271 ALLEQIFcanGYSNEFSGLCGALFIVFGILGALLLGLYVDRtkhFTEATKIGLCLTSLTFVAFALVSQLQGQTFALAAIC 350
Cdd:COG2271 205 TYLVEVR---GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR---LGRRRKLVLAIGLLLAALALLLLALLPSPALAIALL 278
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 157822105 351 SLLGLFGFSVAPVVMELAVECSFPVGEGASAGLIFVLGQAeGVLIMLLLTAVTVRRTG 408
Cdd:COG2271 279 FLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFL-GGALGPLLVGYLLDATG 335
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
32-412 |
4.70e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 52.16 E-value: 4.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 32 RRWVFLLVVSLLSCSNAMLWLTFAPVADTIAQHFSLSMDQINWLSLI----YLVLSIPFGmaaiWVLDSVGLRGATILGA 107
Cdd:COG0738 5 NYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAfflgYLLASLPAG----RLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 108 WLNFSGSLLRAVpclavrIPSpFAFFMSGQSLCALAQTLVISSPAKLAALWFPEHQRATANMIGTMsNPLGILIANVLSP 187
Cdd:COG0738 81 LLMALGLLLFAL------APS-YPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAF-FSLGALLGPLLGG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 188 ALVKKAEDIPMMLGiYIVPAALACLLATVCLWESVPPTPPSAGAASSTSESFLHglklLMKNKAYVILAVCF----GGGI 263
Cdd:COG0738 153 LLILLGLSLSWHLP-YLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKS----LLKNPRLLLGGLAIflyvGAEG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 264 GVFSSFSALLEQIFcanGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKhfteATKIGLCLTSLTFVAFALVSQLQGQT 343
Cdd:COG0738 228 AIGDWLPLYLKDVL---GLSEATAALGLSLFWGGMTIGRFLGGFLLKRFG----PVRLLRLSALLAAVGLLLALLAPGPW 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157822105 344 FALAAIcSLLGLFGFSVAPVVMELAVEcSFPVGEGASAGLIFVLGQAeGVLIMLLLTAVTVRRTGPSFS 412
Cdd:COG0738 301 LALIGL-ALVGLGLSLMFPTIFSLALD-GLGKRTAAAVSAVLIMGIV-GGAIGPPLIGFLADAFGLRAA 366
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
162-365 |
3.96e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.13 E-value: 3.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 162 HQRATANMIGTMSNPLGILIANVLSPALVK-----KAEDIPMMLGIYIVPAALACLLATVCLWESVPPTPPSAgaassts 236
Cdd:COG2211 143 EERTRLSSWRFAFAGLGGLLASVLPPPLVAafggdAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKV------- 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 237 eSFLHGLKLLMKNKAYVILAVCFGGGIGVFSSFSALLEQIF-CANGYSNEFSGLCGALFIVFGILGALLLGLYVDRT-KH 314
Cdd:COG2211 216 -SLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFkYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFgKK 294
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 157822105 315 FTeaTKIGLCLTSLTFVAFALVSQLQGQTFALAAICSLLGLFGFSVAPVVM 365
Cdd:COG2211 295 KA--FIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAM 343
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
37-402 |
5.78e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 48.34 E-value: 5.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 37 LLVVSLLSCSNAMLWLTFAPVadtIAQHFSLSMDQINWL----SLIYLVLSIPFGMAAiwvlDSVGLRGATILGAwlnfs 112
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPL---YAESLGASVAQIGLIvaayALAQLLFSPPAGRLS----DRFGRKRLLLLGL----- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 113 gsLLRAVPCLAVRIPSPFAFFMSGQSLCALAQTLVISSPAKLAALWFPEHQRATANMIGTMSNPLGILIANVLSPALVkk 192
Cdd:cd17325 69 --LLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLA-- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 193 aeDIPMMLGIYIVPAALAcLLATVCLWESVPPTPPSAGAASSTSESFLHGLKLLMKNKAYVILAVCFGGGIGVFSSFSAL 272
Cdd:cd17325 145 --DALGYRAPFLVCAALA-LLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 273 L----EQIFcanGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKHFTEATkIGLCLTSLTFVAFALVSQLqgqtFALAA 348
Cdd:cd17325 222 LplyaAELG---GLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLIL-IGLLLSAVALLLLPLATSF----WLLLL 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 157822105 349 ICSLLGLFGFSVAPVVMELAVECSFPVGEGASAGL---IFVLGQAEGVLIMLLLTAV 402
Cdd:cd17325 294 LLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLfntAFSLGMVLGPLLGGFLYDA 350
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
55-372 |
5.67e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 45.23 E-value: 5.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 55 APVADTIAQHFSLSMDQINWL----SLIYLVLSIPFGMAAiwvlDSVGLRGATILGAwlnfsgsLLRAVPCLAVRIPSPF 130
Cdd:cd17324 19 QGLLPDIARDFGVSVAQAGLLvsayALGYALGALLLGPLS----DRIERRRLLLVLL-------LLFILGNLLAALAPSF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 131 AFFMSGQSLCALAQTLVISSPAKLAALWFPEHQRATA-------NMIGTM-SNPLGILIANVLSPALVkkaedipmMLGI 202
Cdd:cd17324 88 ALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAiglvfsgLTLGLVlGRPLGGLLGQLLGWRAA--------FLAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 203 yivpaALACLLATVCLWESVPPTPPSAgaasSTSESFLHGLKLLMKNK----AYVILAVCFGGGIGVFSSFSALLEQIFc 278
Cdd:cd17324 160 -----AVLALLAALLLWRLLPSLPPKK----PGSLGLLSSLLLLLRNPrlrlAYLITFLLFGGFFALYTYLAPFLTDVP- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 279 anGYSNEFSGLCGALFIVFGILGALLLGLYVDRtkHFTEATKIGLCLTSLTFVAFALVSQLqgqTFALAAICSLLGLFGF 358
Cdd:cd17324 230 --GFSSSAIIGLLLLFGVAGVVGSPLAGRLADR--GGRRALLIALLLLAAALLLLTLLGPS---PLLLLVGLVLWGLGFF 302
|
330
....*....|....
gi 157822105 359 SVAPVVMELAVECS 372
Cdd:cd17324 303 AAHSALQTRVLRLA 316
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
49-277 |
1.07e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 44.60 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 49 MLWLTFAPVA-DTIAQHFSLSMDQINWLSLIYL----VLSIPFGMAaiwvLDSVGLRGATILGAwlnfsgsLLRAVPCLA 123
Cdd:TIGR00886 15 LVWFAFSPLAvFLIKDDLGLSTAQLGNLVAVPVlagaVLRIILGFL----VDIFGPRYTTALSL-------LLLAIPCLW 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 124 VRIP-SPFAFFMSGQSLCALA-QTLVISSPakLAALWFPEHQRATANMIGTMSNPLGILIANVLSPALV----------- 190
Cdd:TIGR00886 84 AGLAvQSYSVLLLIRLFIGIAgGSFASCMP--WISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIgslifgggqpa 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 191 KKAEDIPMMLGIYIVPAALACLLATVCLWESVPPTPPSAGAASSTSESFLHGLKLLMkNKAYVilaVCFGGGIGVFSSFS 270
Cdd:TIGR00886 162 HLAWGWAFVIVPAGILLLPALLIFFVGADTPPGKPATGKLSFKEALKVFGNRHTWIL-ALLYS---VTFGSFLGVSSIFA 237
|
....*..
gi 157822105 271 ALLEQIF 277
Cdd:TIGR00886 238 MLFKDQF 244
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
49-277 |
7.22e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 41.85 E-value: 7.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 49 MLWLTFAPVADTIAQHFSLSMDQINWLSLIYLVLSIPFGMAAIWVLDSVGLRGATILgawlnfsGSLLRAVPCLAV-RIP 127
Cdd:cd17341 13 MVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIA-------SLLLLLIPLLALaLAV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 128 SPFAFFMSGQSLCALA-QTLVISSPakLAALWFPEHQRATANM-IGTMSNpLGILIANVLSPALVKKAEDIPMMLG---I 202
Cdd:cd17341 86 SSYWGLLVLGFLLGFAgANFASGQP--WASFWFPKEKIGGAAGgIAGAGN-MGVAVSQLLAPLIAGAIVFDGGFVGwrnA 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157822105 203 YIVPAALAcLLATVCLWESVPPTPPSAGAASSTSESFLHGLkllmKNKAYVILAVCFGGGIGVFSSFSALLEQIF 277
Cdd:cd17341 163 FFVPGILL-AIAAVLVLLFGDDLPTGKASALEFLKVQLAVL----KNYRTWILSLLYGVTFGSFVGFSNVLPTYF 232
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
33-214 |
1.02e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 41.44 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 33 RWVFLLVVSLLSCSNAMLWLTFAPVADTIAQHFSLSMDQINWLSLIYLVLSIPFGMAAIWVLDSVGLRGATILGAWLNFS 112
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 113 GSLLRAVpclavrIPSPFAFFMSGQSLCALAQTLVISSPAKLAALWFPEHqRATANMIGTMSNPLGILIANVLSPALVKK 192
Cdd:cd17353 81 GFILSAF------AISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINT 153
|
170 180
....*....|....*....|..
gi 157822105 193 AEDIPMMLGIYIVPAALACLLA 214
Cdd:cd17353 154 VGVPTTFLILGIIFLIIIVIGA 175
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
34-389 |
1.54e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 40.72 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 34 WVFLLVVSLLSCSNAMLWLTFAPVADTIAQHFSLSMDQInwlSLIYLVLSIPFGMAAI---WVLDSVGLRGATILGAWLn 110
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVI---SLAFTVGLLAFGLAQPfvgRLLDRFGPRRVMLLGLLL- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 111 FSGSLLravpcLAVRIPSPFAFFMSGqSLCALAQTLVISSPAKLA-ALWFPEHQRATANMIGTMSNPLGILIANVLSPAL 189
Cdd:cd17355 78 LAAGLV-----LLALATSLWQLYLLW-GLLGGGGAGTLAAVAFATvAAWWFERRRGLALGILTAGGGLGSLVFLPLGAAL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 190 VKKAEDIPMMLGIYIVpaALACLLATVCLWESVPPTPPSAGAASSTSESFLHGLKLLMKNKAYVILAVCFGGGIGVFSSF 269
Cdd:cd17355 152 IEAFGWRTALLVLALL--ALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 270 SALLEQIFCANGYSNEFSGLCGALFIVFGILGALLLGLYVDRtkhfTEATKIGLCLTSLTFVAFALVSQLQGQTFALAAI 349
Cdd:cd17355 230 IVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDR----YSPRRLLAASYALRALGLALLLLLPFPPLALLLF 305
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 157822105 350 CSLLGLFGFSVAPVVMELAVEcSFPVGEGASA-GLIFVLGQ 389
Cdd:cd17355 306 AALFGLGWGATVPLTAALAAR-YFGARSYGTLfGLVFAPHQ 345
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
31-273 |
1.67e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.56 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 31 ARRWVFLLVVSLLSCSNAMLWLTFAPVADTIAQHFSLSMDQINWLSLIYLVLSIPFGMAAIWVLDSVGLRGATILGAWLN 110
Cdd:COG0477 10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 111 FSGSLLRAVpclavrIPSPfAFFMSGQSLCALAQTLVISSPAKLAALWFPEHQRATANMIGTMSNPLGILIANVLSPALV 190
Cdd:COG0477 90 GLASLLCGL------APSP-ELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 191 kKAEDIPMMLGIyIVPAALACLLATVCLWESVPPTPPSAGAASSTSESFLHGLKLLMKNKAYVILAVCFGGGIGVFSSFS 270
Cdd:COG0477 163 -AALGWRWIFLI-NAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALL 240
|
...
gi 157822105 271 ALL 273
Cdd:COG0477 241 LLL 243
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
37-267 |
1.97e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 40.68 E-value: 1.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 37 LLVVSLLscsNAMLWLTFAPVADTIAQHFSLSMDQINWLS----LIYLVLSIPFGMAAI-----WVLdSVGL---RGATI 104
Cdd:cd17328 4 LFLINLL---NYMDRFTIAGVLPDIQSDFLIDDSLAGLLQtvfiISYMVLSPIFGYLGDrynrkWIL-AVGIliwSAATL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 105 LGAWLNFSGSLL--RAVpclaVRIpspfaffmsGQSLCA-LAQTLVISSpaklaalwFPEHQRATANMIGTMSNPLGILI 181
Cdd:cd17328 80 LSSFAPNFWQLLlfRAL----VGI---------GEASYSpIAPTIIADL--------FPKEKRTRALGVFYFAIPLGSGL 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 182 ANVLSPALVKKAEDIPMmlgIYIVPAALACLLATVCLWesVPPTPPSAGAA-----SSTSESFLHGLKLLMKNKAYVIla 256
Cdd:cd17328 139 GYVVGGLVAQATGGWRW---AFRVTGVLGVLLAILLLL--FVREPPRGAAEggvmaKSTATSFLADLKALAKNPSFIL-- 211
|
250
....*....|.
gi 157822105 257 VCFGGGIGVFS 267
Cdd:cd17328 212 STLGFTAVSFV 222
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
160-410 |
9.73e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.31 E-value: 9.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 160 PEHQRATANMIGTMSNPLGILIANVLsPALVKKAEDIPMMLGIYIVpaaLACLLATVCLWESVPPTPPSAGAASstsesf 239
Cdd:cd17477 114 TNENRGRVLGLYSTVLGLGFALGPLL-LALVGTAGALPFLIAAVLL---LLALVPLLLTRRAAPEIEEAESISL------ 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 240 lhgLKLLMKNKAYVILAVCFGGGIGVFSSFSALLEQifcANGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKHFteat 319
Cdd:cd17477 184 ---RRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGL---RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRR---- 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822105 320 KIGLCLTSLTFVAFALVSQLQGQTFALAAICSLLGLFGFSVAPVVMELAVEcSFPVGEGASAGLIFVLGQAEGVLIMLLL 399
Cdd:cd17477 254 RVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGD-RLPGDELVAANAALLLLYGLGSVIGPLL 332
|
250
....*....|.
gi 157822105 400 TAVTVRRTGPS 410
Cdd:cd17477 333 AGALMDAFGPH 343
|
|
| |
