F-box only protein 34 [Rattus norvegicus]
Protein Classification
F-box protein( domain architecture ID 1903342)
F-box protein functions as the substrate-recognition component of an SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| F-box_SF super family | cl45894 | F-box domain superfamily; This short domain is commonly found at the N-terminus of various ... |
596-643 | 7.02e-25 | ||
F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures. The actual alignment was detected with superfamily member cd22176: Pssm-ID: 459239 Cd Length: 48 Bit Score: 97.60 E-value: 7.02e-25
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| Name | Accession | Description | Interval | E-value | ||
| F-box_FBXO34 | cd22176 | F-box domain found in F-box only protein 34 (FBXO34) and similar proteins; FBXO34, also called ... |
596-643 | 7.02e-25 | ||
F-box domain found in F-box only protein 34 (FBXO34) and similar proteins; FBXO34, also called FBX34, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438947 Cd Length: 48 Bit Score: 97.60 E-value: 7.02e-25
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| F-box | pfam00646 | F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ... |
598-630 | 3.99e-05 | ||
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 425796 Cd Length: 43 Bit Score: 41.37 E-value: 3.99e-05
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| FBOX | smart00256 | A Receptor for Ubiquitination Targets; |
599-632 | 1.79e-04 | ||
A Receptor for Ubiquitination Targets; Pssm-ID: 197608 Cd Length: 41 Bit Score: 39.34 E-value: 1.79e-04
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| Name | Accession | Description | Interval | E-value | ||
| F-box_FBXO34 | cd22176 | F-box domain found in F-box only protein 34 (FBXO34) and similar proteins; FBXO34, also called ... |
596-643 | 7.02e-25 | ||
F-box domain found in F-box only protein 34 (FBXO34) and similar proteins; FBXO34, also called FBX34, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438947 Cd Length: 48 Bit Score: 97.60 E-value: 7.02e-25
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| F-box_FBXO34-like | cd22105 | F-box domain found in F-box only protein 34 (FBXO34), F-box only protein 46 (FBXO46) and ... |
596-642 | 4.18e-21 | ||
F-box domain found in F-box only protein 34 (FBXO34), F-box only protein 46 (FBXO46) and similar proteins; This family includes FBXO34 (also called FBX34) and FBXO46 (also called FBX46), both of which are substrate-recognition components of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. The SCF(FBOX46) complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438877 Cd Length: 47 Bit Score: 86.69 E-value: 4.18e-21
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| F-box_FBXO46 | cd22177 | F-box domain found in F-box only protein 46 (FBXO46) and similar proteins; FBXO46, also called ... |
596-642 | 9.21e-18 | ||
F-box domain found in F-box only protein 46 (FBXO46) and similar proteins; FBXO46, also called FBX46, or F-box only protein 34-like, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438948 Cd Length: 47 Bit Score: 77.26 E-value: 9.21e-18
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| F-box | pfam00646 | F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ... |
598-630 | 3.99e-05 | ||
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 425796 Cd Length: 43 Bit Score: 41.37 E-value: 3.99e-05
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| F-box-like | pfam12937 | F-box-like; This is an F-box-like family. |
596-630 | 6.70e-05 | ||
F-box-like; This is an F-box-like family. Pssm-ID: 463757 [Multi-domain] Cd Length: 45 Bit Score: 40.54 E-value: 6.70e-05
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| F-box_SF | cd09917 | F-box domain superfamily; This short domain is commonly found at the N-terminus of various ... |
597-631 | 6.80e-05 | ||
F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures. Pssm-ID: 438852 Cd Length: 35 Bit Score: 40.51 E-value: 6.80e-05
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| FBOX | smart00256 | A Receptor for Ubiquitination Targets; |
599-632 | 1.79e-04 | ||
A Receptor for Ubiquitination Targets; Pssm-ID: 197608 Cd Length: 41 Bit Score: 39.34 E-value: 1.79e-04
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