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Conserved domains on  [gi|157821063|ref|NP_001101112|]
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tubby-related protein 1 isoform 2 [Rattus norvegicus]

Protein Classification

tubby family protein( domain architecture ID 10471804)

tubby family protein plays an important role in maintenance and function of neuronal cells during post differentiation and development in mammals, and may participate in the abscisic acid (ABA) signaling pathway in plants

CATH:  3.20.90.10
Gene Ontology:  GO:0006355
PubMed:  21722349
SCOP:  4001052

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Tub pfam01167
Tub family;
221-462 9.89e-132

Tub family;


:

Pssm-ID: 460094  Cd Length: 251  Bit Score: 380.77  E-value: 9.89e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821063  221 LQPAPQGRAVRCRLTRDKKGMdrGMYPSYFLHLD---TEKKVFLLAGRKRKRSKTANYLISSDPTNLSRGGENFIGKLRS 297
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLElspGDGGKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821063  298 NLLGNRFTVFDN-----GQNPQRGGGG----DVESLRQELAAVVYETNVLGFRGPRRMTVIIPGMNSDNERVPIRPRnSS 368
Cdd:pfam01167  79 NFLGTKFTLYDNqppynGANPSKSRSSfgskKVSPGRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQ-SE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821063  369 DGLLVRWQNKTLESLIELHNKPPIWNEDSGSYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLC 448
Cdd:pfam01167 158 SSLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPLS 237
                         250
                  ....*....|....
gi 157821063  449 ALQAFAIALSSFDG 462
Cdd:pfam01167 238 AFQAFAICLSSFDT 251
PHA03247 super family cl33720
large tegument protein UL36; Provisional
24-113 4.21e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 4.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821063   24 SPEPPPRPKQRP-AQGQKLRKKKPETPESPESKPPRRAGAGRRKHGEPPADPAEPRTEQTVYAKflRDPEAKKRDPREtf 102
Cdd:PHA03247  417 TPAPTPVPASAPpPPATPLPSAEPGSDDGPAPPPERQPPAPATEPAPDDPDDATRKALDALRER--RPPEPPGADLAE-- 492
                          90
                  ....*....|.
gi 157821063  103 LVARAPDVGGG 113
Cdd:PHA03247  493 LLGRHPDTAGT 503
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
24-210 4.34e-03

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 39.67  E-value: 4.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821063  24 SPEPPPRPKQRPA----QGQKLRK--KKPETPESPESK-PPRRAGAGRRKHG-------EPPADPA---EPRTEQTVYAK 86
Cdd:PTZ00449 599 RPRSAQRPTRPKSpklpELLDIPKspKRPESPKSPKRPpPPQRPSSPERPEGpkiikspKPPKSPKppfDPKFKEKFYDD 678
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821063  87 FL----RDPEAKKRDPRETFLVARAPDVGGGDVGSPDAPQKPLKTKKKEVGEGTkLRKVKKKGAGETDK----NPSESPA 158
Cdd:PTZ00449 679 YLdaaaKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEEFP-FEPIGDPDAEQPDDieffTPPEEER 757
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 157821063 159 TVRKKIPASMFLvgEGGTAEKGVKKKVMRNSNQKGRAKGKGKKKEERAPSPP 210
Cdd:PTZ00449 758 TFFHETPADTPL--PDILAEEFKEEDIHAETGEPDEAMKRPDSPSEHEDKPP 807
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
221-462 9.89e-132

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 380.77  E-value: 9.89e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821063  221 LQPAPQGRAVRCRLTRDKKGMdrGMYPSYFLHLD---TEKKVFLLAGRKRKRSKTANYLISSDPTNLSRGGENFIGKLRS 297
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLElspGDGGKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821063  298 NLLGNRFTVFDN-----GQNPQRGGGG----DVESLRQELAAVVYETNVLGFRGPRRMTVIIPGMNSDNERVPIRPRnSS 368
Cdd:pfam01167  79 NFLGTKFTLYDNqppynGANPSKSRSSfgskKVSPGRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQ-SE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821063  369 DGLLVRWQNKTLESLIELHNKPPIWNEDSGSYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLC 448
Cdd:pfam01167 158 SSLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPLS 237
                         250
                  ....*....|....
gi 157821063  449 ALQAFAIALSSFDG 462
Cdd:pfam01167 238 AFQAFAICLSSFDT 251
PHA03247 PHA03247
large tegument protein UL36; Provisional
24-113 4.21e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 4.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821063   24 SPEPPPRPKQRP-AQGQKLRKKKPETPESPESKPPRRAGAGRRKHGEPPADPAEPRTEQTVYAKflRDPEAKKRDPREtf 102
Cdd:PHA03247  417 TPAPTPVPASAPpPPATPLPSAEPGSDDGPAPPPERQPPAPATEPAPDDPDDATRKALDALRER--RPPEPPGADLAE-- 492
                          90
                  ....*....|.
gi 157821063  103 LVARAPDVGGG 113
Cdd:PHA03247  493 LLGRHPDTAGT 503
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
24-210 4.34e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 39.67  E-value: 4.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821063  24 SPEPPPRPKQRPA----QGQKLRK--KKPETPESPESK-PPRRAGAGRRKHG-------EPPADPA---EPRTEQTVYAK 86
Cdd:PTZ00449 599 RPRSAQRPTRPKSpklpELLDIPKspKRPESPKSPKRPpPPQRPSSPERPEGpkiikspKPPKSPKppfDPKFKEKFYDD 678
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821063  87 FL----RDPEAKKRDPRETFLVARAPDVGGGDVGSPDAPQKPLKTKKKEVGEGTkLRKVKKKGAGETDK----NPSESPA 158
Cdd:PTZ00449 679 YLdaaaKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEEFP-FEPIGDPDAEQPDDieffTPPEEER 757
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 157821063 159 TVRKKIPASMFLvgEGGTAEKGVKKKVMRNSNQKGRAKGKGKKKEERAPSPP 210
Cdd:PTZ00449 758 TFFHETPADTPL--PDILAEEFKEEDIHAETGEPDEAMKRPDSPSEHEDKPP 807
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
221-462 9.89e-132

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 380.77  E-value: 9.89e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821063  221 LQPAPQGRAVRCRLTRDKKGMdrGMYPSYFLHLD---TEKKVFLLAGRKRKRSKTANYLISSDPTNLSRGGENFIGKLRS 297
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLElspGDGGKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821063  298 NLLGNRFTVFDN-----GQNPQRGGGG----DVESLRQELAAVVYETNVLGFRGPRRMTVIIPGMNSDNERVPIRPRnSS 368
Cdd:pfam01167  79 NFLGTKFTLYDNqppynGANPSKSRSSfgskKVSPGRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQ-SE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821063  369 DGLLVRWQNKTLESLIELHNKPPIWNEDSGSYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLC 448
Cdd:pfam01167 158 SSLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPLS 237
                         250
                  ....*....|....
gi 157821063  449 ALQAFAIALSSFDG 462
Cdd:pfam01167 238 AFQAFAICLSSFDT 251
PHA03247 PHA03247
large tegument protein UL36; Provisional
24-113 4.21e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 4.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821063   24 SPEPPPRPKQRP-AQGQKLRKKKPETPESPESKPPRRAGAGRRKHGEPPADPAEPRTEQTVYAKflRDPEAKKRDPREtf 102
Cdd:PHA03247  417 TPAPTPVPASAPpPPATPLPSAEPGSDDGPAPPPERQPPAPATEPAPDDPDDATRKALDALRER--RPPEPPGADLAE-- 492
                          90
                  ....*....|.
gi 157821063  103 LVARAPDVGGG 113
Cdd:PHA03247  493 LLGRHPDTAGT 503
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
24-210 4.34e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 39.67  E-value: 4.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821063  24 SPEPPPRPKQRPA----QGQKLRK--KKPETPESPESK-PPRRAGAGRRKHG-------EPPADPA---EPRTEQTVYAK 86
Cdd:PTZ00449 599 RPRSAQRPTRPKSpklpELLDIPKspKRPESPKSPKRPpPPQRPSSPERPEGpkiikspKPPKSPKppfDPKFKEKFYDD 678
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821063  87 FL----RDPEAKKRDPRETFLVARAPDVGGGDVGSPDAPQKPLKTKKKEVGEGTkLRKVKKKGAGETDK----NPSESPA 158
Cdd:PTZ00449 679 YLdaaaKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEEFP-FEPIGDPDAEQPDDieffTPPEEER 757
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 157821063 159 TVRKKIPASMFLvgEGGTAEKGVKKKVMRNSNQKGRAKGKGKKKEERAPSPP 210
Cdd:PTZ00449 758 TFFHETPADTPL--PDILAEEFKEEDIHAETGEPDEAMKRPDSPSEHEDKPP 807
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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