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Conserved domains on  [gi|157820139|ref|NP_001101213|]
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equilibrative nucleobase transporter 1 [Rattus norvegicus]

Protein Classification

MFS transporter( domain architecture ID 1905563)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FucP super family cl43255
Fucose permease [Carbohydrate transport and metabolism];
51-165 6.76e-03

Fucose permease [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG0738:

Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 38.68  E-value: 6.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820139  51 VLGGNATGLPDLKAQ----DEKFSLIFTLASFMNNFMTFPTGYIFDRFKTAVARLLAIFFYTCATLIIAFtsADTAMLLF 126
Cdd:COG0738   23 ATALWGPLIPALKDAfglsDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFAL--APSYPLLL 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 157820139 127 LAMPMLAVG-GILFLITNLQIGNLFGKHRSTIITFYNGAF 165
Cdd:COG0738  101 LALFLLGLGlGLLDVAANPYVAALGPETAASRLNLLHAFF 140
 
Name Accession Description Interval E-value
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
51-165 6.76e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 38.68  E-value: 6.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820139  51 VLGGNATGLPDLKAQ----DEKFSLIFTLASFMNNFMTFPTGYIFDRFKTAVARLLAIFFYTCATLIIAFtsADTAMLLF 126
Cdd:COG0738   23 ATALWGPLIPALKDAfglsDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFAL--APSYPLLL 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 157820139 127 LAMPMLAVG-GILFLITNLQIGNLFGKHRSTIITFYNGAF 165
Cdd:COG0738  101 LALFLLGLGlGLLDVAANPYVAALGPETAASRLNLLHAFF 140
MFS_1 pfam07690
Major Facilitator Superfamily;
70-172 8.78e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.17  E-value: 8.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820139   70 SLIFTLASFMNNFMTFPTGYIFDRFKTAVARLLAIFFYTCATLIIAFTSADTAMLLFLAMPMLA--VGGILFLITNLQIG 147
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLgfGFGLVFPALNALVS 317

                          90       100
                  ....*....|....*....|....*.
gi 157820139  148 NLFGKH-RSTIITFYNGAFDSSSAVF 172
Cdd:pfam07690 318 DLAPKEeRGTASGLYNTAGSLGGALG 343
 
Name Accession Description Interval E-value
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
51-165 6.76e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 38.68  E-value: 6.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820139  51 VLGGNATGLPDLKAQ----DEKFSLIFTLASFMNNFMTFPTGYIFDRFKTAVARLLAIFFYTCATLIIAFtsADTAMLLF 126
Cdd:COG0738   23 ATALWGPLIPALKDAfglsDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFAL--APSYPLLL 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 157820139 127 LAMPMLAVG-GILFLITNLQIGNLFGKHRSTIITFYNGAF 165
Cdd:COG0738  101 LALFLLGLGlGLLDVAANPYVAALGPETAASRLNLLHAFF 140
MFS_1 pfam07690
Major Facilitator Superfamily;
70-172 8.78e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.17  E-value: 8.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820139   70 SLIFTLASFMNNFMTFPTGYIFDRFKTAVARLLAIFFYTCATLIIAFTSADTAMLLFLAMPMLA--VGGILFLITNLQIG 147
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLgfGFGLVFPALNALVS 317

                          90       100
                  ....*....|....*....|....*.
gi 157820139  148 NLFGKH-RSTIITFYNGAFDSSSAVF 172
Cdd:pfam07690 318 DLAPKEeRGTASGLYNTAGSLGGALG 343
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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