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Conserved domains on  [gi|157819159|ref|NP_001101466|]
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kelch-like protein 21 [Rattus norvegicus]

Protein Classification

kelch-like protein 21( domain architecture ID 13033132)

kelch-like protein 21 (KLHL21) is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis

Gene Symbol:  KLHL21
Gene Ontology:  GO:0005515
PubMed:  19995937|27387502|23676014|17120193|15544948|10603472

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-138 6.30e-75

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 234.66  E-value: 6.30e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  14 DPAHALSLLRGLSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDF 93
Cdd:cd18250    1 DPAHALHLLRGLSELRAERKFFDVTLCA-GGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDF 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 157819159  94 SYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANC 138
Cdd:cd18250   80 SYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 133-232 4.23e-57

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


:

Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 186.93  E-value: 4.23e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPP 211
Cdd:cd18460    1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELaKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                         90       100
                 ....*....|....*....|.
gi 157819159 212 RRAAHWPQLLEAVRLPFVRRF 232
Cdd:cd18460   81 HRQHFWPELLQHVRLPFVRRF 101
PHA03098 super family cl33709
kelch-like protein; Provisional
 49-547 9.25e-41

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 155.31  E-value: 9.25e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  49 AHRAVLAAASPYFRAMFAGQLREsraERVRLHGvPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAF 128
Cdd:PHA03098  25 VHKIILSSSSEYFKKMFKNNFKE---NEINLNI-DYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINY 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 129 LQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGA-EQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVR 207
Cdd:PHA03098 101 IIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNdPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLT 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 208 ADPPRRAAHWPQLLEAVRLPFVRrfyllahveaeplvarcPPCLRLLREAR-DFQAARYDRHDRGPC---------PRMR 277
Cdd:PHA03098 181 SKKNNKYKDICLILKVLRITFLS-----------------EEGIKKLKRWKlRIKKKKIVFNKRCIKiiyskkynlNKIL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 278 PRPSTGLAEILVLvggcDQDCDELVTVDCYNPQTGQWRYLAEfpDHLGGGYSIVALGNDIYVTGGSDGSRL-YDCVWRYN 356
Cdd:PHA03098 244 PRSSTFGSIIYIH----ITMSIFTYNYITNYSPLSEINTIID--IHYVYCFGSVVLNNVIYFIGGMNKNNLsVNSVVSYD 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 357 SSVNEWTEVAPMLKAREYHSSSVLNGLLYVVAA-------DSTERYDHATDSWEALQPMTYPMDNCSTTACRGRLYAIGS 429
Cdd:PHA03098 318 TKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGiynsislNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 430 LA--GKETMVIQCYDPDTDLWSMVNCgqLPPWSFAPKTVTLNGLMYFVRDDSAE--------VDVYNPTKDEWDKIPSMN 499
Cdd:PHA03098 398 ISknDELLKTVECFSLNTNKWSKGSP--LPISHYGGCAIYHDGKIYVIGGISYIdnikvyniVESYNPVTNKWTELSSLN 475

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*...
gi 157819159 500 QVHVGGSLAALGGKLYVSGGYDNTFELSDvVEAYDPETRAWSVVGRLP 547
Cdd:PHA03098 476 FPRINASLCIFNNKIYVVGGDKYEYYINE-IEVYDDKTNTWTLFCKFP 522
 
Name Accession Description Interval E-value
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-138 6.30e-75

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 234.66  E-value: 6.30e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  14 DPAHALSLLRGLSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDF 93
Cdd:cd18250    1 DPAHALHLLRGLSELRAERKFFDVTLCA-GGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDF 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 157819159  94 SYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANC 138
Cdd:cd18250   80 SYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 133-232 4.23e-57

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 186.93  E-value: 4.23e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPP 211
Cdd:cd18460    1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELaKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                         90       100
                 ....*....|....*....|.
gi 157819159 212 RRAAHWPQLLEAVRLPFVRRF 232
Cdd:cd18460   81 HRQHFWPELLQHVRLPFVRRF 101
PHA03098 PHA03098
kelch-like protein; Provisional
 49-547 9.25e-41

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 155.31  E-value: 9.25e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  49 AHRAVLAAASPYFRAMFAGQLREsraERVRLHGvPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAF 128
Cdd:PHA03098  25 VHKIILSSSSEYFKKMFKNNFKE---NEINLNI-DYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINY 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 129 LQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGA-EQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVR 207
Cdd:PHA03098 101 IIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNdPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLT 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 208 ADPPRRAAHWPQLLEAVRLPFVRrfyllahveaeplvarcPPCLRLLREAR-DFQAARYDRHDRGPC---------PRMR 277
Cdd:PHA03098 181 SKKNNKYKDICLILKVLRITFLS-----------------EEGIKKLKRWKlRIKKKKIVFNKRCIKiiyskkynlNKIL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 278 PRPSTGLAEILVLvggcDQDCDELVTVDCYNPQTGQWRYLAEfpDHLGGGYSIVALGNDIYVTGGSDGSRL-YDCVWRYN 356
Cdd:PHA03098 244 PRSSTFGSIIYIH----ITMSIFTYNYITNYSPLSEINTIID--IHYVYCFGSVVLNNVIYFIGGMNKNNLsVNSVVSYD 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 357 SSVNEWTEVAPMLKAREYHSSSVLNGLLYVVAA-------DSTERYDHATDSWEALQPMTYPMDNCSTTACRGRLYAIGS 429
Cdd:PHA03098 318 TKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGiynsislNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 430 LA--GKETMVIQCYDPDTDLWSMVNCgqLPPWSFAPKTVTLNGLMYFVRDDSAE--------VDVYNPTKDEWDKIPSMN 499
Cdd:PHA03098 398 ISknDELLKTVECFSLNTNKWSKGSP--LPISHYGGCAIYHDGKIYVIGGISYIdnikvyniVESYNPVTNKWTELSSLN 475

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*...
gi 157819159 500 QVHVGGSLAALGGKLYVSGGYDNTFELSDvVEAYDPETRAWSVVGRLP 547
Cdd:PHA03098 476 FPRINASLCIFNNKIYVVGGDKYEYYINE-IEVYDDKTNTWTLFCKFP 522
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
289-534 1.26e-37

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 140.68  E-value: 1.26e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 289 VLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPdhlGGGYS---IVALGNDIYVTGGSDG----SRLYDCVWRYNSSVNE 361
Cdd:COG3055   25 VYVAGGLSGGSASNSFEVYDPATNTWSELAPLP---GPPRHhaaAVAQDGKLYVFGGFTGanpsSTPLNDVYVYDPATNT 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 362 WTEVAPMLKAREYHSSSVLNGLLYVV-------AADSTERYDHATDSWEALQPMTYPMDNCS-TTACRGRLYAIGSLAGk 433
Cdd:COG3055  102 WTKLAPMPTPRGGATALLLDGKIYVVggwddggNVAWVEVYDPATGTWTQLAPLPTPRDHLAaAVLPDGKILVIGGRNG- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 434 etmviqcyDPDTDLWSmvNCGQLPPWSFAPKTVTLNGLMYFV---RDDSAEVDVYNPTKDEWDKIPSMNQVHVGGSLAAL 510
Cdd:COG3055  181 --------SGFSNTWT--TLAPLPTARAGHAAAVLGGKILVFggeSGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLT 250

                        250       260
                 ....*....|....*....|....*..
gi 157819159 511 GGKLYVSGGYDNT---FELSDVVEAYD 534
Cdd:COG3055  251 DGKVYVIGGETKPgvrTPLVTSAEVYD 277
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 25-133 6.78e-35

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 127.37  E-value: 6.78e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159   25 LSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVaVSGD 104
Cdd:pfam00651   1 LNELREQGELCDVTL-VVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*....
gi 157819159  105 NAEPLLRAADLLQFPAVKEACGAFLQQQL 133
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 138-239 9.39e-32

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 118.42  E-value: 9.39e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  138 CLDMQDFAEAFSCSGLASAAQRFILRHVGELGA-EQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAH 216
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKsEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 157819159  217 WPQLLEAVRLPFVRRFYLLAHVE 239
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 36-133 1.39e-27

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 106.62  E-value: 1.39e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159    36 DVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADL 115
Cdd:smart00225   1 DVTL-VVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 157819159   116 LQFPAVKEACGAFLQQQL 133
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 138-237 1.10e-26

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 103.96  E-value: 1.10e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159   138 CLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAH 216
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVsSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 157819159   217 WPQLLEAVRLPFVRRFYLLAH 237
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 327-368 4.84e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 54.93  E-value: 4.84e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 157819159  327 GYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWTEVAPM 368
Cdd:pfam01344   4 GAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45
Kelch smart00612
Kelch domain;
337-382 2.93e-09

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 52.95  E-value: 2.93e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 157819159   337 IYVTGGSDGSRLYDCVWRYNSSVNEWTEVAPMLKAREYHSSSVLNG 382
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
 
Name Accession Description Interval E-value
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-138 6.30e-75

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 234.66  E-value: 6.30e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  14 DPAHALSLLRGLSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDF 93
Cdd:cd18250    1 DPAHALHLLRGLSELRAERKFFDVTLCA-GGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDF 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 157819159  94 SYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANC 138
Cdd:cd18250   80 SYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 133-232 4.23e-57

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 186.93  E-value: 4.23e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPP 211
Cdd:cd18460    1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELaKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                         90       100
                 ....*....|....*....|.
gi 157819159 212 RRAAHWPQLLEAVRLPFVRRF 232
Cdd:cd18460   81 HRQHFWPELLQHVRLPFVRRF 101
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-139 6.04e-45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 155.76  E-value: 6.04e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  10 LPFSDPAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQL 89
Cdd:cd18259    8 LDFCLPSHPQSILDGLQTLRSNPKLSDVTL-LVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMES 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 157819159  90 LLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCL 139
Cdd:cd18259   87 LIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCL 136
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-139 2.12e-44

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 154.10  E-value: 2.12e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18256    3 HASLILAQLNKLRGQHEFCDVQLQV-GMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYT 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCL 139
Cdd:cd18256   82 GVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCI 124
PHA03098 PHA03098
kelch-like protein; Provisional
 49-547 9.25e-41

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 155.31  E-value: 9.25e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  49 AHRAVLAAASPYFRAMFAGQLREsraERVRLHGvPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAF 128
Cdd:PHA03098  25 VHKIILSSSSEYFKKMFKNNFKE---NEINLNI-DYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINY 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 129 LQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGA-EQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVR 207
Cdd:PHA03098 101 IIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNdPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLT 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 208 ADPPRRAAHWPQLLEAVRLPFVRrfyllahveaeplvarcPPCLRLLREAR-DFQAARYDRHDRGPC---------PRMR 277
Cdd:PHA03098 181 SKKNNKYKDICLILKVLRITFLS-----------------EEGIKKLKRWKlRIKKKKIVFNKRCIKiiyskkynlNKIL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 278 PRPSTGLAEILVLvggcDQDCDELVTVDCYNPQTGQWRYLAEfpDHLGGGYSIVALGNDIYVTGGSDGSRL-YDCVWRYN 356
Cdd:PHA03098 244 PRSSTFGSIIYIH----ITMSIFTYNYITNYSPLSEINTIID--IHYVYCFGSVVLNNVIYFIGGMNKNNLsVNSVVSYD 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 357 SSVNEWTEVAPMLKAREYHSSSVLNGLLYVVAA-------DSTERYDHATDSWEALQPMTYPMDNCSTTACRGRLYAIGS 429
Cdd:PHA03098 318 TKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGiynsislNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 430 LA--GKETMVIQCYDPDTDLWSMVNCgqLPPWSFAPKTVTLNGLMYFVRDDSAE--------VDVYNPTKDEWDKIPSMN 499
Cdd:PHA03098 398 ISknDELLKTVECFSLNTNKWSKGSP--LPISHYGGCAIYHDGKIYVIGGISYIdnikvyniVESYNPVTNKWTELSSLN 475

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*...
gi 157819159 500 QVHVGGSLAALGGKLYVSGGYDNTFELSDvVEAYDPETRAWSVVGRLP 547
Cdd:PHA03098 476 FPRINASLCIFNNKIYVVGGDKYEYYINE-IEVYDDKTNTWTLFCKFP 522
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-141 6.00e-40

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 142.66  E-value: 6.00e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  12 FSDPAHALSLLRGLSQLRAERKFLDVTLEAAG-------GRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPP 84
Cdd:cd18273    4 LEDAAHARALLAQLKSFYDARLLTDVTIEVNGpgsgpgsGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDS 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 157819159  85 DMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDM 141
Cdd:cd18273   84 ESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGI 140
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-141 1.43e-39

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 141.66  E-value: 1.43e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  12 FSDPAHALSLLRGLSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLH-GVPPDMLQLL 90
Cdd:cd18267   18 FHKSSYADSVLTHLNLLRQQRLFTDVLLHA-GNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHdSIHPEVLELL 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 157819159  91 LDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDM 141
Cdd:cd18267   97 LDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-141 8.58e-39

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 138.77  E-value: 8.58e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  12 FSDPAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLL 91
Cdd:cd18268    1 FKDQDLSSELLRQLNSLRQERILTDVIL-CTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIV 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 157819159  92 DFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDM 141
Cdd:cd18268   80 DYVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
289-534 1.26e-37

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 140.68  E-value: 1.26e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 289 VLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPdhlGGGYS---IVALGNDIYVTGGSDG----SRLYDCVWRYNSSVNE 361
Cdd:COG3055   25 VYVAGGLSGGSASNSFEVYDPATNTWSELAPLP---GPPRHhaaAVAQDGKLYVFGGFTGanpsSTPLNDVYVYDPATNT 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 362 WTEVAPMLKAREYHSSSVLNGLLYVV-------AADSTERYDHATDSWEALQPMTYPMDNCS-TTACRGRLYAIGSLAGk 433
Cdd:COG3055  102 WTKLAPMPTPRGGATALLLDGKIYVVggwddggNVAWVEVYDPATGTWTQLAPLPTPRDHLAaAVLPDGKILVIGGRNG- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 434 etmviqcyDPDTDLWSmvNCGQLPPWSFAPKTVTLNGLMYFV---RDDSAEVDVYNPTKDEWDKIPSMNQVHVGGSLAAL 510
Cdd:COG3055  181 --------SGFSNTWT--TLAPLPTARAGHAAAVLGGKILVFggeSGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLT 250

                        250       260
                 ....*....|....*....|....*..
gi 157819159 511 GGKLYVSGGYDNT---FELSDVVEAYD 534
Cdd:COG3055  251 DGKVYVIGGETKPgvrTPLVTSAEVYD 277
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-139 1.38e-37

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 135.52  E-value: 1.38e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLH-GVPPDMLQLLLDF 93
Cdd:cd18254    3 PSHPDCVLTHLNTLRKQCMFTDVTL-WAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHdSLHPEVLELLLDF 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 157819159  94 SYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCL 139
Cdd:cd18254   82 AYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 127
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-138 2.21e-37

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 134.83  E-value: 2.21e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18255    1 HSVTLLQGLNALRAKGQLLDVTL-IADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANC 138
Cdd:cd18255   80 SELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-138 3.31e-37

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 134.49  E-value: 3.31e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18242    4 HAKSILNTMNSLRKSNTLCDVTLRV-EGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYT 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANC 138
Cdd:cd18242   83 ETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
312-558 4.37e-37

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 139.14  E-value: 4.37e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 312 GQWRYLAEFPDHLGGGYSiVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWTEVAPM-LKAREYHSSSVLNGLLYVV--- 387
Cdd:COG3055    1 ATWSSLPDLPTPRSEAAA-ALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFggf 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 388 --------AADSTERYDHATDSWEALQPMTYPMDNCSTTACRGRLYAI-GSLAGKETMVIQCYDPDTDLWSMVncGQLPP 458
Cdd:COG3055   80 tganpsstPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVgGWDDGGNVAWVEVYDPATGTWTQL--APLPT 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 459 WSFAPKTVTL-NGLMYFV--RDDSAEVdvynptkDEWDKIPSMNQVHVGGSLAALGGKLYVSGGYDNTFelsDVVEAYDP 535
Cdd:COG3055  158 PRDHLAAAVLpDGKILVIggRNGSGFS-------NTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFS---DEVEAYDP 227

                        250       260
                 ....*....|....*....|...
gi 157819159 536 ETRAWSVVGRLPEPTFWHGSVSI 558
Cdd:COG3055  228 ATNTWTALGELPTPRHGHAAVLT 250
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-139 1.54e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 132.41  E-value: 1.54e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  25 LSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGD 104
Cdd:cd18238    6 LHQFYENGELCDVTLKV-GEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLTVD 84

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 157819159 105 NAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCL 139
Cdd:cd18238   85 NVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCL 119
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-138 2.24e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 131.88  E-value: 2.24e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18253    1 HSESILQVFNEFRDSRLFTDVII-CVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANC 138
Cdd:cd18253   80 GKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-134 4.18e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 131.01  E-value: 4.18e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFS 94
Cdd:cd18235    2 PQHTQKAFDVMNELRKQNLLCDVILVA-DGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 157819159  95 YTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLD 134
Cdd:cd18235   81 YTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQLH 120
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-139 5.25e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 127.48  E-value: 5.25e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  36 DVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADL 115
Cdd:cd18234    3 DVIL-IAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACL 81

                         90       100
                 ....*....|....*....|....
gi 157819159 116 LQFPAVKEACGAFLQQQLDLANCL 139
Cdd:cd18234   82 LQLSEVVEACCGFLMKQLHPSNCL 105
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 25-133 6.78e-35

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 127.37  E-value: 6.78e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159   25 LSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVaVSGD 104
Cdd:pfam00651   1 LNELREQGELCDVTL-VVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*....
gi 157819159  105 NAEPLLRAADLLQFPAVKEACGAFLQQQL 133
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-139 1.28e-34

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 127.22  E-value: 1.28e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  22 LRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAV 101
Cdd:cd18237    9 MGVMNNMRKQKTLCDVIL-IVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISV 87

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 157819159 102 SGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCL 139
Cdd:cd18237   88 NSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-134 1.29e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 124.19  E-value: 1.29e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRV-GDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYT 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLD 134
Cdd:cd18257   80 GTVFISQATVESLLPAANLLQIKLVLKECCDFLESQLD 117
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-139 3.54e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 123.34  E-value: 3.54e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  13 SDPAHALSLLRGLSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLD 92
Cdd:cd18265    2 SGPCHAERILQVLNAYRRSGTFTDVVLLV-DGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 157819159  93 FSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCL 139
Cdd:cd18265   81 YMYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCL 127
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-138 9.13e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 119.57  E-value: 9.13e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  12 FSDPAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLL 91
Cdd:cd18236    2 FDDTGLSLVLQNGLENLRLENSLTDVIL-CVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 157819159  92 DFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANC 138
Cdd:cd18236   81 DYTYTSKVLITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENC 127
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 138-239 9.39e-32

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 118.42  E-value: 9.39e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  138 CLDMQDFAEAFSCSGLASAAQRFILRHVGELGA-EQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAH 216
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKsEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 157819159  217 WPQLLEAVRLPFVRRFYLLAHVE 239
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-139 1.36e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 118.77  E-value: 1.36e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  14 DPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDF 93
Cdd:cd18252    1 DSSHPADFLDAFRTFYLDGLFTDITLQCASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNY 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 157819159  94 SYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCL 139
Cdd:cd18252   81 VYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCL 126
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-139 2.87e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 118.17  E-value: 2.87e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  14 DPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDF 93
Cdd:cd18274    2 DPLHACSILQQLKAMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 157819159  94 SYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCL 139
Cdd:cd18274   82 AYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSI 127
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-116 3.32e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 116.11  E-value: 3.32e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  34 FLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAA 113
Cdd:cd18186    1 LCDVTLVV-GGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAA 79


                 ...
gi 157819159 114 DLL 116
Cdd:cd18186   80 DKL 82
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-134 7.97e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 116.71  E-value: 7.97e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLEAAGG---RDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDF 93
Cdd:cd18248    4 HTKEAFQIMNELRLSQQLCDVTLKVKYQdpkEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEF 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 157819159  94 SYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLD 134
Cdd:cd18248   84 AYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQLD 124
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-132 1.71e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 112.76  E-value: 1.71e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  25 LSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGD 104
Cdd:cd18247   10 MEEIRRQGKLCDVTLKV-GDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGRIAIDTS 88

                         90       100
                 ....*....|....*....|....*...
gi 157819159 105 NAEPLLRAADLLQFPAVKEACGAFLQQQ 132
Cdd:cd18247   89 NVQSLLVGASFLQLQSVKDACCEFLKER 116
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-138 2.90e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 112.04  E-value: 2.90e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  16 AHALSLLRglsQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSY 95
Cdd:cd18240    2 AMACNVFN---ELRLEGKLCDVVIRV-NGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAY 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 157819159  96 TGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANC 138
Cdd:cd18240   78 TRTVPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-140 3.26e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 111.97  E-value: 3.26e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18306    1 HPESVLAKLNALRKNRQFCDVILQV-GGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLD 140
Cdd:cd18306   80 SRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIG 123
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-139 3.57e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 112.16  E-value: 3.57e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18249    6 HPRQTLEAINLLRKHRELCDVVL-VVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCL 139
Cdd:cd18249   85 SQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCL 127
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 36-133 1.39e-27

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 106.62  E-value: 1.39e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159    36 DVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADL 115
Cdd:smart00225   1 DVTL-VVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 157819159   116 LQFPAVKEACGAFLQQQL 133
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-133 3.98e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 106.31  E-value: 3.98e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  14 DPAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDF 93
Cdd:cd18338    1 NPRHMKKAFKVMNELRSQNLLCDVTI-VAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDY 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 157819159  94 SYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQL 133
Cdd:cd18338   80 VYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQL 119
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-139 4.92e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 106.34  E-value: 4.92e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  24 GLSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSG 103
Cdd:cd18269   17 GLKDLLDENKFVDCVLKI-GDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLND 95

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157819159 104 DNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCL 139
Cdd:cd18269   96 QNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCL 131
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-138 7.63e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 105.66  E-value: 7.63e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  12 FSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRD-FPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLL 90
Cdd:cd18239    1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGDGDEtFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNI 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 157819159  91 LDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANC 138
Cdd:cd18239   81 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-139 9.80e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 105.30  E-value: 9.80e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  24 GLSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSG 103
Cdd:cd18340   17 GLKDLLDHNKFVDCVLKI-KEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITE 95

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157819159 104 DNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCL 139
Cdd:cd18340   96 QNVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCL 131
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 138-237 1.10e-26

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 103.96  E-value: 1.10e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159   138 CLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAH 216
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVsSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 157819159   217 WPQLLEAVRLPFVRRFYLLAH 237
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-142 3.77e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 103.59  E-value: 3.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18336    2 HAEQTFRKMENYLQHKQLCDVLL-IAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQ 142
Cdd:cd18336   81 GVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGIR 126
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-140 2.63e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 101.41  E-value: 2.63e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  10 LPFSDpAHALSLLRGLSQLRAERKFLDVTLEAAGgRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQL 89
Cdd:cd18264    5 LAYSK-SHGEAVLSQYQSLRAEGFLCDVVLEAEG-NEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQR 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 157819159  90 LLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLD 140
Cdd:cd18264   83 VLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENCCF 133
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-133 2.94e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 100.95  E-value: 2.94e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  14 DPAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDF 93
Cdd:cd18339    1 NPAHMKKAFKVMNELRSKQLLCDVTI-VAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDY 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 157819159  94 SYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQL 133
Cdd:cd18339   80 IYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQL 119
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-137 2.14e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 98.35  E-value: 2.14e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  16 AHALSLLRGLSQLRAERKFLDVTLEAAGgRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSY 95
Cdd:cd18251    5 AHSQALLDGLVALRDSGILFDVVLVVEG-KPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIY 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157819159  96 TGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLAN 137
Cdd:cd18251   84 TSELELSLDNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-142 2.16e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 98.59  E-value: 2.16e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  12 FSDPAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLL 91
Cdd:cd18337    1 FQALNHAEQTFKKMENYLRHKQLCDVVL-VAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALV 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 157819159  92 DFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQ 142
Cdd:cd18337   80 QYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIR 130
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-138 5.51e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 97.62  E-value: 5.51e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  12 FSDPAHALSLLRGLSQLRAERKFLDVTL--EAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLH------GVP 83
Cdd:cd18241    1 FECSSHCSELSWRQNEQRKQGLFCDITLafGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRkwssepGPD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 157819159  84 PDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANC 138
Cdd:cd18241   81 PDTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-130 5.90e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 93.94  E-value: 5.90e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  21 LLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRES--RAERVRLHGVPPDMLQLLLDFSYTGR 98
Cdd:cd18245    1 LLRALNSFREEPHLCDATL-VVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDdgSTYKIELEGISVEVMEEILDYIYTGQ 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157819159  99 VAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130
Cdd:cd18245   80 IKLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-139 6.17e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 94.53  E-value: 6.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  24 GLSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSG 103
Cdd:cd18341   17 GLKELLDENKFVDCTLKA-GDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLND 95

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157819159 104 DNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCL 139
Cdd:cd18341   96 GNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCL 131
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-139 1.37e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 93.33  E-value: 1.37e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLEAAGGRdFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18276    4 HSLTLLDQLNRMKELAELTDVVLVAEGEK-FPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYS 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCL 139
Cdd:cd18276   83 SDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCL 125
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 133-244 1.48e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 92.68  E-value: 1.48e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGE--LGAEQLErLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADP 210
Cdd:cd18445    1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEvvKGEEFLL-LSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDP 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 157819159 211 PRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLV 244
Cdd:cd18445   80 ENRKEHLAELLEHVRLPLLSPEYLVQRVEEEELI 113
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-141 5.11e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 91.82  E-value: 5.11e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18271    7 HGQQILSVLQNFREQNAFFDFNI-IVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYT 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDM 141
Cdd:cd18271   86 GKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 133-260 1.07e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 91.31  E-value: 1.07e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPP 211
Cdd:cd18452    1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVvQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 157819159 212 RRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDF 260
Cdd:cd18452   81 EREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKF 129
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 134-234 1.11e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 90.16  E-value: 1.11e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 134 DLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELgAEQLERLPLAR--LLRYLRDDGLCVPKEEAAYQLALRWVRADPP 211
Cdd:cd18468    1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDV-ARQEEILSISKddIVEYLSHDSLNTKAEELVFETAIKWLKKDPK 79

                         90       100
                 ....*....|....*....|...
gi 157819159 212 RRAAHWPQLLEAVRLPFVRRFYL 234
Cdd:cd18468   80 NRKQHIAELLAVVRLPFIHPSYL 102
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-142 1.28e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 90.87  E-value: 1.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18335    2 HAEQTFRKMESYLKQQQLCDVIL-IAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQ 142
Cdd:cd18335   81 GCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGIR 126
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-140 1.59e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 90.80  E-value: 1.59e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  16 AHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSY 95
Cdd:cd18261   10 SHKDAVLAALNQQRNDGILCDITL-VAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAY 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 157819159  96 TGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLD 140
Cdd:cd18261   89 TGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYLD 133
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-134 2.04e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 90.47  E-value: 2.04e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  25 LSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGD 104
Cdd:cd18246   30 MNRMRQRGLLCDIVLHV-GTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEG 108

                         90       100       110
                 ....*....|....*....|....*....|
gi 157819159 105 NAEPLLRAADLLQFPAVKEACGAFLQQQLD 134
Cdd:cd18246  109 NVQTLLPAASLLQLNGVRDACCKFLLSQLD 138
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 22-140 2.86e-21

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 89.49  E-value: 2.86e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  22 LRGLSQLRAERKFLDVTLEAAGGRdFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAV 101
Cdd:cd18263    1 LQSIEGLWEKGVGCDVQLEADGSI-FRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHL 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 157819159 102 SGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLD 140
Cdd:cd18263   80 SWENLFEATCTALQLQISGALALCLDFLQREISPARCLD 118
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-141 7.00e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 88.91  E-value: 7.00e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18270    9 YAVSLLEQLKFFYEQQLLTDIVL-IVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYT 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDM 141
Cdd:cd18270   88 GNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRL 132
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-139 1.44e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 88.03  E-value: 1.44e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  12 FSDPAHALSLLRGLSQL-RAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLL 90
Cdd:cd18272    9 FTDRSHSSRVAQSIMDLcLEDGLFADVTI-SVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLL 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 157819159  91 LDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCL 139
Cdd:cd18272   88 VDYIYHGTVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCL 136
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-139 1.01e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 85.41  E-value: 1.01e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  21 LLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAER---VRLHGVPPDMLQLLLDFSYTG 97
Cdd:cd18258    4 MLKELNQQRRAKEFTDLKI-IVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEkleLTMSNINADVLELLLEFVYTG 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157819159  98 RVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCL 139
Cdd:cd18258   83 SLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCL 124
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-140 1.21e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 84.86  E-value: 1.21e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAgqlRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18260    1 YGANLLEGLNRMRQERFLCDLTI-ATKTKSFDVHKVVMASCSEYFRNILK---KDPSLQRVELNDISPLGLATVITYAYT 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLD 140
Cdd:cd18260   77 GKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCMY 120
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-130 1.83e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 84.51  E-value: 1.83e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  10 LPFsdPAHALSLLRGLSQLRAERKFLDVTLEAAGGRdFPAHRAVLAAASPYFRAMFAGQLRESRAERV-------RLHGV 82
Cdd:cd18327    3 IPF--PEHSSELLSCLNEQRRAGLLCDLTIKTRGLE-YRTHRAVLAACSLYFRKLFTGGGGGSGDLGAgggqdvcELDFV 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 157819159  83 PPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130
Cdd:cd18327   80 GPEALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-137 2.07e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 83.86  E-value: 2.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  44 GRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRV---AVSGDNAEPLLRAADLLQFPA 120
Cdd:cd18297   21 GRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVeslDVAQDDALELLRAASFFQLDG 100

                         90
                 ....*....|....*..
gi 157819159 121 VKEACGAFLQQQLDLAN 137
Cdd:cd18297  101 LKRHCEILLSQQIDLDN 117
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-137 2.52e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 83.73  E-value: 2.52e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSllRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFS 94
Cdd:cd18279    1 PECRLA--EDLGNLWENSRFTDCCL-CVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFI 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 157819159  95 YTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLAN 137
Cdd:cd18279   78 YTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 33-125 8.55e-19

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 81.62  E-value: 8.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  33 KFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRA 112
Cdd:cd18314    5 EFSDVVL-CVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLML 83

                         90
                 ....*....|...
gi 157819159 113 ADLLQFPAVKEAC 125
Cdd:cd18314   84 ASKYQVPDLEKLC 96
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-129 9.92e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 82.28  E-value: 9.92e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  33 KFLDVTLEAAGGRdFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSG---DNAEPL 109
Cdd:cd18287   21 EYSDVTFVVEEKR-FPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYTGRLTLTDlkeDVLLDV 99

                         90       100
                 ....*....|....*....|
gi 157819159 110 LRAADLLQFPAVKEACGAFL 129
Cdd:cd18287  100 LGLAHQYGFEELEAAISDYL 119
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 34-117 1.23e-18

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 80.67  E-value: 1.23e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  34 FLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAErVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAA 113
Cdd:cd18315    1 LVDVTL-ACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPV-IILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLA 78


                 ....
gi 157819159 114 DLLQ 117
Cdd:cd18315   79 ELLQ 82
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-129 1.67e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 81.52  E-value: 1.67e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  10 LPFsdPAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQL 89
Cdd:cd18326    3 IPF--PDHSSDILSSLNEQRTQGLLCDVVI-LVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTA 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 157819159  90 LLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFL 129
Cdd:cd18326   80 LLDFAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-145 1.79e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 81.86  E-value: 1.79e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLEAAGGRdFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18266    8 HSNLVLQGLNEQRQRGLFCDVVLVADEQR-VPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVIDFLYS 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFA 145
Cdd:cd18266   87 SELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 133-231 2.31e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 80.43  E-value: 2.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELG-AEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPP 211
Cdd:cd18456    1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSkTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                         90       100
                 ....*....|....*....|
gi 157819159 212 RRAAHWPQLLEAVRLPFVRR 231
Cdd:cd18456   81 GRRQHVPRLMKCVRLPLLSR 100
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-130 8.14e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 79.53  E-value: 8.14e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  10 LPFsdPAHALSLLRGLSQLRAERKFLDVTLEAAGgRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQL 89
Cdd:cd18198    3 IPF--PDHSSEILSGLNEQRTQGLLCDVVILVQG-REYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTA 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 157819159  90 LLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130
Cdd:cd18198   80 LLEFAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 133-238 1.42e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 78.50  E-value: 1.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGA-EQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPP 211
Cdd:cd18457    1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKsEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                         90       100
                 ....*....|....*....|....*..
gi 157819159 212 RRAAHWPQLLEAVRLPFVRRFYLLAHV 238
Cdd:cd18457   81 NREEYLPELLSKVRLPLLRPQFLTDRV 107
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-128 1.77e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 78.26  E-value: 1.77e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFagqlRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDV-GGRVFKAHWSVLACCSHFFQSLY----GDGTSGSVVLPESFAEVFGLLLDFFYT 75

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAF 128
Cdd:cd18232   76 GELALTRENRDRVLLAAKELRVPEAVELCQRF 107
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 137-261 3.57e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 78.18  E-value: 3.57e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 137 NCLDMQDFAEAFSCSGLASAAQRFILRHVGE-LGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAA 215
Cdd:cd18513    5 NCLGIRAFADVHTCTELLQQANAYAEQHFPEvMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKEARLE 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 157819159 216 HWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQ 261
Cdd:cd18513   85 HMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-137 9.50e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 76.43  E-value: 9.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  25 LSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGD 104
Cdd:cd18345    9 LGLLFERSAFSDVTL-CVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKAPNLDK 87

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157819159 105 NAEPLLRAADLLQFPAVKEACGAFLQQQLDLAN 137
Cdd:cd18345   88 MADDLLAAADKYALERLKVMCEEALCSNLSVEN 120
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-137 1.14e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 76.62  E-value: 1.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  14 DPAHALSLLRGLSQLRAERKFLDVTLEAAGgRDFPAHRAVLAAASPYFRAMFAgqlresrAERVRLHGVPPDMLQLLLDF 93
Cdd:cd18243   12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQG-QQFHCHKAVLASCSQYFRSLFS-------INNLVLQGCSSIGLRLVLEY 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 157819159  94 SYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLAN 137
Cdd:cd18243   84 LYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-137 1.77e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 75.81  E-value: 1.77e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  25 LSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGD 104
Cdd:cd18343   12 LGNLWENSRFTDCSL-FVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDK 90

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157819159 105 NAEPLLRAADLLQFPAVKEACGAFLQQQLDLAN 137
Cdd:cd18343   91 MADNLLAAADKYALERLKVMCEEALCNNLSVEN 123
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 136-261 1.96e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 75.84  E-value: 1.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 136 ANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRA 214
Cdd:cd18512    4 TNCLGIRAFADMHACTELLNQANTYAEQHFSDVvLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKEVRQ 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 157819159 215 AHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQ 261
Cdd:cd18512   84 EHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-141 6.70e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 74.61  E-value: 6.70e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  12 FSDPAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLL 91
Cdd:cd18244    8 YNSSIHDTSVSAGFRALYEEGLLLDVTL-VIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVL 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 157819159  92 DFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDM 141
Cdd:cd18244   87 QFMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEI 136
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-131 8.91e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 74.23  E-value: 8.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAER-KFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAER-VRLHGVPPDMLQLLLDFS 94
Cdd:cd18207    9 HSADMLHNLNQQRKSGgRFCDVLLRV-GEESFPAHRAVLAACSEYFESVFSAQEGDGGTPReLEMHTISSKVFGDILDFA 87

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 157819159  95 YTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQ 131
Cdd:cd18207   88 YTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQ 124
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 131-233 1.07e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 72.87  E-value: 1.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 131 QQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELG-AEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRAD 209
Cdd:cd18469    1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSqEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80

                         90       100
                 ....*....|....*....|....
gi 157819159 210 PPRRAAHWPQLLEAVRLPFVRRFY 233
Cdd:cd18469   81 PQARAAHLPELLSLVHLSLLTDQY 104
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 44-137 1.12e-15

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 73.28  E-value: 1.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  44 GRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKE 123
Cdd:cd18352   22 GRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAADQYLLEGLKR 101

                         90
                 ....*....|....
gi 157819159 124 ACGAFLQQQLDLAN 137
Cdd:cd18352  102 LCEYTIAQDLTLEN 115
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 34-134 1.13e-15

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 73.48  E-value: 1.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  34 FLDVTLEAAGgRDFPAHRAVLAAASPYFRAMFAGQLRESRAER-----VRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEP 108
Cdd:cd18296   17 FPDVCFQVEG-HRFPCHKAFFCGRSDYFKALLRDHFAESEENNgsipvVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYD 95

                         90       100
                 ....*....|....*....|....*.
gi 157819159 109 LLRAADLLQFPAVKEACGAFLQQQLD 134
Cdd:cd18296   96 VLYVADMYLLPGLKRLCGTVLAQSLD 121
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-133 3.14e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 72.59  E-value: 3.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLEAAGgRDFPAHRAVLAAASPYFRAMFAGQLRE-----SRAER--VRLHGVPPDMLQL 89
Cdd:cd18228    2 HSQELLGKLNSLRNEGHFCDVTIRVQD-KIFRAHKVVLAACSDFFRSKLVGQASPrlvlvSPAGKcvLDLHHVTVTGFAP 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 157819159  90 LLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQL 133
Cdd:cd18228   81 LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
PHA02790 PHA02790
Kelch-like protein; Provisional
 28-542 3.19e-15

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 78.55  E-value: 3.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  28 LRAERKFLDVtLEAAGGrDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRL-HGVPPDMLQLLLDFSYTGRVAVSGDNA 106
Cdd:PHA02790  16 LSMTKKFKTI-IEAIGG-NIIVNSTILKKLSPYFRTHLRQKYTKNKDPVTRVcLDLDIHSLTSIVIYSYTGKVYIDSHNV 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 107 EPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLARLLRYLR 186
Cdd:PHA02790  94 VNLLRASILTSVEFIIYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLELEDDIIDNFDYLSMKLILE 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 187 DDGLCVPKEEAAYQLALRWVRadppRRAAHWPQLLEAVRlPFVRRFYLlahveaeplvarcppclrllreardfqaaryd 266
Cdd:PHA02790 174 SDELNVPDEDYVVDFVIKWYM----KRRNRLGNLLLLIK-NVIRSNYL-------------------------------- 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 267 rhdrgpcprmRPRPSTGLAEILvlvggcdqDCDELVTVDcYNPQTgQWRY-LAEFPDHLGGGYSIVAL------GNDIYV 339
Cdd:PHA02790 217 ----------SPRGINNVKWIL--------DCTKIFHCD-KQPRK-SYKYpFIEYPMNMDQIIDIFHMctsthvGEVVYL 276

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 340 TGGSDGSRLYDCVWRYNSSVNEWTEVAPMLKAREYHSSSVLNGLLYVVAA----DSTERYDHATDSWEALQPMTYPMDNC 415
Cdd:PHA02790 277 IGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGlpnpTSVERWFHGDAAWVNMPSLLKPRCNP 356

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 416 STTACRGRLYAIGSLAGKETMViQCYDPDTDLWsmvncgQLPPWSFAP--KTVTLN-GLMYFVRDDSAEvdVYNPTKDEW 492
Cdd:PHA02790 357 AVASINNVIYVIGGHSETDTTT-EYLLPNHDQW------QFGPSTYYPhyKSCALVfGRRLFLVGRNAE--FYCESSNTW 427

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 157819159 493 DKIPSMNQVHVGGSLAALGGKLYVSGGYDNTFELsDVVEAYDPETRAWSV 542
Cdd:PHA02790 428 TLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYI-DTIEVYNNRTYSWNI 476
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-130 3.26e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 71.81  E-value: 3.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18332    2 HSSDVLLNLNELRKRDILTDVTL-LVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLDFMYT 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130
Cdd:cd18332   81 SRLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-129 1.16e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 70.48  E-value: 1.16e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159   8 AVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRdFPAHRAVLAAASPYFRAMFAGQ----LRESRAERVRLHGVP 83
Cdd:cd18277    1 SVFAYESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQR-FRAHRSVLAACSSYFHSRIVGQadaeLNITLPEEVTVKGFE 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 157819159  84 PdmlqlLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFL 129
Cdd:cd18277   80 P-----LIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-133 1.82e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 70.24  E-value: 1.82e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGqlRESRAERVRLHG--VPPDMLQLLLD 92
Cdd:cd18194    4 PEHSRQLLQCLREQRSQGFLCDCTV-LVGSAQFPAHRAVLASCSMYFHLFYRD--RLDKRDLVRLNSdiVTAPAFGLLLD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 157819159  93 FSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQL 133
Cdd:cd18194   81 FMYEGRLALRDLPVEDVLAAASYLHMYDIVKVCKGRLQEKA 121
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-137 2.03e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 69.98  E-value: 2.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  14 DPAHALSllRGLSQLRAERKFLDVTLEAAGgRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDF 93
Cdd:cd18344    5 DPRHMLT--DDLGELWENSLFTDCCLLVAG-HEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGF 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 157819159  94 SYTGRVAV--SGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLAN 137
Cdd:cd18344   82 IYTGKAPHlhSHSMACDVLAAADKYGLEGLKVLCEDALCRNLSVEN 127
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-141 2.07e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 69.44  E-value: 2.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  36 DVTLEAaGGRDFPAHRAVLAAASPYFRAmfagqlRESRaERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADL 115
Cdd:cd18275    6 DLVIEV-SGQRIRAHKSVLAAKSDYFRA------RLSR-DILKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARF 77

                         90       100
                 ....*....|....*....|....*.
gi 157819159 116 LQFPAVKEACGAFLQQQLDLANCLDM 141
Cdd:cd18275   78 LQMPCAAQCAVDAVRAQLCLGNCYEV 103
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 132-227 2.41e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 69.28  E-value: 2.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 132 QLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQ-LERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADP 210
Cdd:cd18444    1 QLHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQeFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDL 80

                         90
                 ....*....|....*..
gi 157819159 211 PRRAAHWPQLLEAVRLP 227
Cdd:cd18444   81 PERKKHLAKLLALIRLP 97
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 134-209 3.16e-14

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 67.82  E-value: 3.16e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157819159 134 DLANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRAD 209
Cdd:cd18508    1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEViQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-129 3.30e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 69.59  E-value: 3.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159   5 APLAVlpFSDPAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRE----SRAERVRLH 80
Cdd:cd18278    4 SPMYV--YESTVHCTNILLCLNDQRKQDILCDVTL-IVEGKEFRAHRAVLAACSEYFLQALVGQTENdlvvSLPEEVTAR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 157819159  81 GVPPdmlqlLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFL 129
Cdd:cd18278   81 GFGP-----LLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 36-124 4.22e-14

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 68.82  E-value: 4.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  36 DVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGrVAVSGDNAEP--LLRAA 113
Cdd:cd18286   19 DITIKV-DGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGG-VLDLPDDVNLgeLLSLA 96

                         90
                 ....*....|.
gi 157819159 114 DLLQFPAVKEA 124
Cdd:cd18286   97 DMYGLDGLKDV 107
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-129 4.47e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 68.43  E-value: 4.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  49 AHRAVLAAASPYFRAMFAGQLR-ESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGA 127
Cdd:cd18294   30 AHKCILAARCEVFRAMFLTGPQkESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEVLAAAVEYGLDELRKLCER 109


                 ..
gi 157819159 128 FL 129
Cdd:cd18294  110 FI 111
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-137 4.53e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 68.97  E-value: 4.53e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  25 LSQLRAERKFLDVTLEAAGgRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGD 104
Cdd:cd18342   13 LGGLWENSRFTDCCLCVAG-QEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDK 91

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157819159 105 NAEPLLRAADLLQFPAVKEACGAFLQQQLDLAN 137
Cdd:cd18342   92 MADDLLAAADKYALERLKVMCEDALCSNLSVEN 124
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 43-116 5.38e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 67.31  E-value: 5.38e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157819159  43 GGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLL 116
Cdd:cd01165    6 EGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-131 8.19e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 68.37  E-value: 8.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  10 LPFSDPAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAgqLRESRAERVRLHGVPPDMLQL 89
Cdd:cd18203    1 LRFQLPGHEAATLRNMNQLRSEERFCDVTI-VADSLKFRGHKVVLAACSPFLRDQFL--LNPSSELQVSLMHSSRVVADL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157819159  90 LLDfSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQ 131
Cdd:cd18203   78 LLS-CYTGALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQ 118
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-128 8.38e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 67.98  E-value: 8.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESrAERVRLHGVP-PDMLQLLLDFSY 95
Cdd:cd18215    2 HASDVLLNLNRLRSRDILTDVVL-VVGREQFRAHKTVLMACSGLFYSIFTDQLKNN-VSVINLDPEIePEGFRILLDFMY 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157819159  96 TGRVAVSGDNAEPLLRAADLLQFPAVKEACGAF 128
Cdd:cd18215   80 TSRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-126 1.27e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 67.51  E-value: 1.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  34 FLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLR-ESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRA 112
Cdd:cd18293   15 FCDVLLQA-EGESVPAHCCVLSACSPYLTERLSSEPPpAGQKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLAA 93

                         90
                 ....*....|....
gi 157819159 113 ADLLQFPAVKEACG 126
Cdd:cd18293   94 ARRLQISELESLCL 107
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 133-229 1.53e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 66.69  E-value: 1.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGA-EQLERLPLARLLRYLRDDGLCvPKEEAAYQLALRWVRADPP 211
Cdd:cd18476    1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAAsEDLKELCASELLDYLGDDELC-GEEEQVFETLMVWIRHDPK 79

                         90
                 ....*....|....*...
gi 157819159 212 RRAAHWPQLLEAVRLPFV 229
Cdd:cd18476   80 ARKGYIHDLFKKVRLQYV 97
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-128 2.15e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 66.88  E-value: 2.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQlresrAERVRLHGVPPDMLQLLLDFS 94
Cdd:cd18206    3 PQHSQHVLEQLNQQRQLGLLCDCTF-VVDGVDFKAHKAVLAACSEYFRMLFVDQ-----KDVVHLDISNAAGLGQVLEFM 76

                         90       100       110
                 ....*....|....*....|....*....|....
gi 157819159  95 YTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAF 128
Cdd:cd18206   77 YTAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 132-207 4.06e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 64.72  E-value: 4.06e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157819159 132 QLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGA-EQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVR 207
Cdd:cd18463    1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQhEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVY 77
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 132-227 5.08e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 65.14  E-value: 5.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 132 QLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGE-LGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADP 210
Cdd:cd18459    1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEvMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                         90
                 ....*....|....*..
gi 157819159 211 PRRAAHWPQLLEAVRLP 227
Cdd:cd18459   81 QERRPHLPQVLQHVRLP 97
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-129 6.91e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 65.14  E-value: 6.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRES-RAERVRLHGVPPDMLQLLLDFSY 95
Cdd:cd18199    1 HQSRLLGQLNEQRKQDFFCDCSI-IVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTgRPSTASFDVFSSDAFSIILDFVY 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 157819159  96 TGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFL 129
Cdd:cd18199   80 SGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-129 1.02e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 64.57  E-value: 1.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDvTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQlreSRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18218    1 HSDRLLHLAARLRPAGALCD-TLITVGSQEFPAHSLVLAGASQQLGRQLTNP---NPGQWCLGEGISPSTFKQLLDFVYG 76

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAFL 129
Cdd:cd18218   77 ESVEVQPGELRPLLEAARALEVESLEEACWRAL 109
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 132-228 1.56e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 63.92  E-value: 1.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 132 QLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADP 210
Cdd:cd18447    1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVyKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                         90
                 ....*....|....*...
gi 157819159 211 PRRAAHWPQLLEAVRLPF 228
Cdd:cd18447   81 PNRQPYMVDILAKVRFPL 98
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-125 1.77e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 64.00  E-value: 1.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRaERKFL-DVTLeAAGGRDFPAHRAVLAAASPYFRAMFagqlRESRAERVRL--HGVPPDMLQLLLDF 93
Cdd:cd18217    1 HCEQLLERLNKQR-EAGFLcDCTI-VIGQFQFKAHRNVLAAFSEYFGAQY----KDTEDNIVFLdqSQVSADGFQKLLEF 74

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157819159  94 SYTGRVAVSGDNAEPLLRAADLLQFPAVKEAC 125
Cdd:cd18217   75 IYTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 133-229 2.45e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 63.21  E-value: 2.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGE--LGAEQLErLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADP 210
Cdd:cd18485    1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEvcLHEEVLE-IEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNR 79

                         90
                 ....*....|....*....
gi 157819159 211 PRRAAHWPQLLEAVRLPFV 229
Cdd:cd18485   80 KSRVQHLVELLKQVRLELV 98
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-113 3.18e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 63.76  E-value: 3.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQL-------------RESRAERVRLHGVP 83
Cdd:cd18195    1 HAGALLLQLNEQRLRGLFCDVTL-IAGDTKFRAHRSVLAASSPYFRELLSSPLplgaaavaaapgaTQSPERVLELPGVK 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 157819159  84 PDMLQLLLDFSYTGRVAVSGDNAEPLLRAA 113
Cdd:cd18195   80 AGVFSDVLNFIYSSRVALPGSAAAKELGAA 109
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-129 3.27e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 63.31  E-value: 3.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  16 AHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGV-PPDMLQLLLDFS 94
Cdd:cd18329    3 SHQSRLLQQLDEQRKQELFCDCSI-LVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVfSPDTFTIILDFV 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 157819159  95 YTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFL 129
Cdd:cd18329   82 YSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 23-125 3.45e-12

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 63.00  E-value: 3.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  23 RGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLresraeRVRLHG-VPPDMLQLLLDFSYTGRVAV 101
Cdd:cd18299    1 EDLRNLLHSPSCADVVFILQGGVRIFAHRIVLAAASSVFADLFLMMT------VVTLDSdITPEAFRRVLEFLYTGVLDE 74

                         90       100
                 ....*....|....*....|....
gi 157819159 102 SGDNAEPLLRAADLLQFPAVKEAC 125
Cdd:cd18299   75 NEDDLKELKDAAELLELFDLVMMC 98
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 133-225 4.01e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 62.52  E-value: 4.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGA--EQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADP 210
Cdd:cd18482    1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQQLLAkeEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80

                         90
                 ....*....|....*
gi 157819159 211 PRRAAHWPQLLEAVR 225
Cdd:cd18482   81 KERAASAAEVLKCVR 95
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 34-125 4.24e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 63.03  E-value: 4.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  34 FLDVTLEAAGGRdFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDN-AEPLLRA 112
Cdd:cd18300    9 FSDVTFIVEDGT-IPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEDGdCVGLIVL 87

                         90
                 ....*....|...
gi 157819159 113 ADLLQFPAVKEAC 125
Cdd:cd18300   88 ANRLCLPRLVALC 100
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-130 4.26e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 63.12  E-value: 4.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  10 LPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGgRDFPAHRAVLAAASPYFRAMFA-GQLRESRAERVRlhgvPPDMLQ 88
Cdd:cd18220    1 IQFDVPEYSNTVLSQLNELRLQGKLCDIIVHIQG-QPFRAHKAVLAASSPYFRDHSAlSTMSGLSISVIK----NPNVFE 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157819159  89 LLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130
Cdd:cd18220   76 QLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILE 117
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-129 4.59e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 63.02  E-value: 4.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  25 LSQLRAERK---FLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRES-RAERVRLHGVPPDMLQLLLDFSYTGRVA 100
Cdd:cd18330    6 LGELNEQRKrdfFCDCSI-IVEGRIFKAHRNILFANSGYFRALLIHYIQDSgRHSTASLDIVTSEAFSIILDFLYSGKLD 84

                         90       100
                 ....*....|....*....|....*....
gi 157819159 101 VSGDNAEPLLRAADLLQFPAVKEACGAFL 129
Cdd:cd18330   85 LCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 132-221 4.74e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 62.31  E-value: 4.74e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 132 QLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELG-AEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADP 210
Cdd:cd18458    1 QLDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSqSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDE 80

                         90
                 ....*....|.
gi 157819159 211 PRRAAHWPQLL 221
Cdd:cd18458   81 ENRRQYLEALL 91
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-125 5.09e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 62.98  E-value: 5.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  10 LPFsdPAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQL 89
Cdd:cd18328    3 IPF--PNHSSEVLCSLNEQRHDGLLCDVVL-IVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSA 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157819159  90 LLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEAC 125
Cdd:cd18328   80 ILEFAYTSTLTITTSNVKHILNAAQMLEIQCIINVC 115
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 132-234 5.14e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 62.78  E-value: 5.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 132 QLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQ-LERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADP 210
Cdd:cd18511    1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQeFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                         90       100
                 ....*....|....*....|....
gi 157819159 211 PRRAAHWPQLLEAVRLPFVRRFYL 234
Cdd:cd18511   81 EQRRKDLSKLLAYIRLPLLAPQFL 104
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-125 7.29e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 62.73  E-value: 7.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  36 DVTLEAAGgRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYT----------GRVAVSGDN 105
Cdd:cd18280   16 DVTFNVDG-EKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKdelpddvepaGSDSSSLDT 94

                         90       100
                 ....*....|....*....|..
gi 157819159 106 --AEPLLRAADLLQFPAVKEAC 125
Cdd:cd18280   95 tmAQHLLAAADRYALERLRLLC 116
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-123 8.31e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 62.75  E-value: 8.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFagqlRESRAERVRLHG-VPPDMLQLLLDF 93
Cdd:cd18290    8 PNFGNSILECLNEQRLQGLYCDVSV-VVKGHAFKAHRAVLAASSSYFRDLF----NSSRSAVVELPAaVQPQSFQQILSF 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 157819159  94 SYTGRVAVSGDNAEPLLRAADLLQFPAVKE 123
Cdd:cd18290   83 CYTGRLSMNVGDQFLLMYTAGFLQIQEIME 112
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-123 9.30e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 62.74  E-value: 9.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQlreSRAERVRLHGVPPDMLQLLLDFS 94
Cdd:cd18289   10 PNFGNTVLGCLNEQRLMGLYCDVSI-VVKGQAFKAHRAVLAASSLYFRDLFSGN---SKSAFELPATVPPACFQQILSFC 85

                         90       100
                 ....*....|....*....|....*....
gi 157819159  95 YTGRVAVSGDNAEPLLRAADLLQFPAVKE 123
Cdd:cd18289   86 YTGKLTMAASEQLVVMYTAGFLQIQHIVE 114
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-132 9.57e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 62.25  E-value: 9.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  47 FPAHRAVLAAASPYFRAMFAGQLRESRAErVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACG 126
Cdd:cd18231   28 FPAHKGVLAAYSQFFHSLFTQNKQLQRVE-LSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLNAAAVLQMNDIAASCQ 106


                 ....*.
gi 157819159 127 AFLQQQ 132
Cdd:cd18231  107 ELIDSR 112
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 133-206 1.08e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 60.48  E-value: 1.08e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGA-EQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWV 206
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAAsAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-128 1.68e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 60.97  E-value: 1.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  34 FLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAE---RVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLL 110
Cdd:cd18307    1 FCDVVISV-DNHSFAAHRNVLAAVSPFVKSLISSNDMKATDElsiTIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLL 79

                         90
                 ....*....|....*...
gi 157819159 111 RAADLLQFPAVKEACGAF 128
Cdd:cd18307   80 KGAKYFNIPRLKDHCVDF 97
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-129 1.78e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 60.56  E-value: 1.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  36 DVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRE----SRAERVRLHGVPPdmlqlLLDFSYTGRVAVSGDNAEPLLR 111
Cdd:cd18955    3 DVTI-VVEDQRFRAHRAVLAACSDYFLSRVVGQTDGdlviTLPEEVTVKGFEP-----LLQFAYTAKLLLSKENVLEVCR 76

                         90
                 ....*....|....*...
gi 157819159 112 AADLLQFPAVKEACGAFL 129
Cdd:cd18955   77 CAEFLGVHNIEKACFDFL 94
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-136 2.11e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 61.61  E-value: 2.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAG-QLRESRAERVRLHGVPPDMLQLLLDF 93
Cdd:cd18230    2 TSHYRHLLRELNEQRQHGILCDVCI-IVEGKIFKAHKNVLLGSSRYFKTLYCQvQKTSDQATVTHLDIVTAQGFKAIIDF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 157819159  94 SYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLA 136
Cdd:cd18230   81 MYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDIS 123
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-128 2.29e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 61.15  E-value: 2.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  20 SLLRGLSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFA-GQLRESRAERVRLHGVPP--DMLQLLLDFSYT 96
Cdd:cd18292    3 EFLQDIAQLYNNEELSDIVLRV-GGKVFHAHRLILAKSSDVFRVMLSnDWWSESKQSEIELVEDPEcaAVFEKFLRYLYT 81

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAF 128
Cdd:cd18292   82 GQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-130 2.36e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 61.21  E-value: 2.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRAERKFLDVTLEAAGgRDFPAHRAVLAAASPYFR-AMFAGQLRESRAERVRlhgvPPDMLQLLLDF 93
Cdd:cd18222    6 PDFSNSVLSHLNQLRMQGRLCDIVVNVQG-QSFRAHKVVLAASSPYFRdHMSLNEMSTVSISVIK----NPTVFEQLLSF 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 157819159  94 SYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130
Cdd:cd18222   81 CYTGRICLQLADIISYLTAASFLQMQHIIDKCTQILE 117
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 136-229 2.61e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 60.42  E-value: 2.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 136 ANCLDMQDFAEAFSCSGLASAAQRFILRHVGE-LGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRA 214
Cdd:cd18509    5 SNCLGIRAFADAQGCIELMKVAHSYTMENIMEvIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRC 84

                         90
                 ....*....|....*
gi 157819159 215 AHWPQLLEAVRLPFV 229
Cdd:cd18509   85 SDLSMLLAYIRLPLL 99
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-130 3.10e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 60.72  E-value: 3.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYframFAGQLRESRAERVRLHGV-PPDMLQLLLDF 93
Cdd:cd18227    6 PDFSSTILQKLNQQRQQGQLCDISV-VVQGHLFRAHKAVLAASSPY----FCDQVLLKNSRRIVLPDVmNPRVFENILLS 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 157819159  94 SYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130
Cdd:cd18227   81 CYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELLE 117
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 133-229 4.32e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 59.58  E-value: 4.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPP 211
Cdd:cd18467    1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVcQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                         90
                 ....*....|....*...
gi 157819159 212 RRAAHWPQLLEAVRLPFV 229
Cdd:cd18467   81 ERQKYLAQLLHCVRLPLL 98
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 136-227 4.60e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 59.63  E-value: 4.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 136 ANCLDMQDFAEAFSCSGLASAAQRFILRHVGE---------LGAEQLERLplarllryLRDDGLCVPKEEAAYQLALRWV 206
Cdd:cd18448    5 SNCLGVRTFAEQHNRVDLMKMADKYACDHFNEvveceefvsISAQHLEKL--------ISSSDLNVESESQVYEAVMKWV 76

                         90       100
                 ....*....|....*....|.
gi 157819159 207 RADPPRRAAHWPQLLEAVRLP 227
Cdd:cd18448   77 KHDPQHRKRHLDDLLSQVRLP 97
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-133 4.97e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 60.64  E-value: 4.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  16 AHALSLLRGLSQLRAERKFLDVTL--EAAGGR-DFPAHRAVLAAASPYFRAMFAGQ-LRESRAERVRLHGVPPDMLQLLL 91
Cdd:cd18211    7 SAPSNLLNEMHKLRLLGHLCDVTVqvEHQGSKeEFSAHKAVLAASSKYFKEVFLNEkISDGKNTNVMLNEIYTADFASFL 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157819159  92 DFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQL 133
Cdd:cd18211   87 EFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQLKKQML 128
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 17-121 6.36e-11

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 59.14  E-value: 6.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRamfaGQLRESRAERVRLHG-VPPDMLQLLLDFSY 95
Cdd:cd18262    1 HPSQFFGEAQRLREQRLLLDETV-SVGGRSYGVHSVILAAVSSLFR----ERLLGSNGPLPPLSLeVTPVGWEAVLTFAY 75

                         90       100
                 ....*....|....*....|....*.
gi 157819159  96 TGRVAVSGDNAEPLLRAADLLQFPAV 121
Cdd:cd18262   76 TGVLGRNPATVGDILVAAEALGAPRV 101
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-130 7.63e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 58.73  E-value: 7.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  43 GGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQfpAVK 122
Cdd:cd18319    9 EDRCYNVSKRKLIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHESQGDSTDTLEENELLE--DLV 86


                 ....*...
gi 157819159 123 EAcGAFLQ 130
Cdd:cd18319   87 EA-ASFLQ 93
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 132-229 8.52e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 59.16  E-value: 8.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 132 QLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQ-LERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADP 210
Cdd:cd18510    1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQeFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                         90
                 ....*....|....*....
gi 157819159 211 PRRAAHWPQLLEAVRLPFV 229
Cdd:cd18510   81 QNRQKDLGMLLSYIRLPLL 99
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 133-210 9.73e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 58.01  E-value: 9.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRH---VGELGAEQLErLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRAD 209
Cdd:cd18450    1 LTPENCIGIRKFARYYFCPELERKAYRYILRNfeeVAKDSEEFLE-LSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79


                 .
gi 157819159 210 P 210
Cdd:cd18450   80 P 80
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 34-137 9.92e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 59.30  E-value: 9.92e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  34 FLDVTLEAAGGRDFPAHRAVLAAASPYFRAMF-AGQLRESRAERVRLHgVPPDMLQLLLDFSYTGRVAV--SGDNAEPL- 109
Cdd:cd18302    5 LYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLsSSWIEASSCSALTMP-IPSDILEIILDYLYTDEASAvkESQNVEFLc 83

                         90       100       110
                 ....*....|....*....|....*....|
gi 157819159 110 --LRAADLLQFPAVKEACGAFLQQQLDLAN 137
Cdd:cd18302   84 nvLVIADQLLITRLKEICEVALVELLSLKN 113
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 44-114 1.03e-10

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 59.19  E-value: 1.03e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157819159  44 GRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAAD 114
Cdd:cd18295   28 GESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTGRLEIHVDDVEDCKRLAK 98
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 137-239 1.20e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 58.63  E-value: 1.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 137 NCLDMQDFAEAFSCSGLASAAQRFILRHVGE-LGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAA 215
Cdd:cd18446    5 NCVGILRLADAHSLESLKKQVQNYIIQNFSQvLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKESERLP 84

                         90       100
                 ....*....|....*....|....
gi 157819159 216 HWPQLLEAVRLPFVRRFYLLAHVE 239
Cdd:cd18446   85 LLPRVLENVRLPLLDPWYFVETVE 108
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-129 1.22e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 59.07  E-value: 1.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVrlhgVPPDMLQLLLDFS 94
Cdd:cd18225    4 PNYSRQLLQQLHTLRKEQQFCDCTI-FIGTFHFRAHKLVLAASSLLFKSLLDSTDTISIDASV----VSPEEFALLLEMV 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 157819159  95 YTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFL 129
Cdd:cd18225   79 YTGKLPPGKHNFTKIISVADSLQMFDVAVSCKNLL 113
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-129 1.32e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 58.70  E-value: 1.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRAERKFLDVTLEAAGgRDFPAHRAVLAAASPYFRamfaGQLRESRAERVRLHGV-PPDMLQLLLDF 93
Cdd:cd18210    2 PEITSSLLESLNQQRMEGKLCDISIHVQG-RVFRAHRAVLAASSPYFH----DQVLLKNMSSISLPGVmDPGAFESVLAS 76

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157819159  94 SYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFL 129
Cdd:cd18210   77 AYTGKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-132 1.79e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 59.06  E-value: 1.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRaERKFL-DVTLEAAGGRdFPAHRAVLAAASPYFRAMFAGQLRESRaERVRLHG--VPPDMLQLLL 91
Cdd:cd18956    4 PEHGGRLLGRLRQQR-ELGFLcDCTVLVGDAR-FPAHRAVLAACSVYFHLFYRDRPAGGR-DTVRLNGdiVTAPAFGRLL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 157819159  92 DFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQ 132
Cdd:cd18956   81 DFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLREK 121
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 133-213 2.60e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 56.95  E-value: 2.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL--GAEQLErLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADP 210
Cdd:cd18480    1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLsqSQEFLE-LNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDL 79


                 ...
gi 157819159 211 PRR 213
Cdd:cd18480   80 EAR 82
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-117 2.84e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 57.70  E-value: 2.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAErvrLHGVPPDMLQLLLDFSYT 96
Cdd:cd18221    1 HYKVMLDRLNEQRELDQFTDITL-IVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPLVE---IEGVSNMAFRHLIEFTYT 76

                         90       100
                 ....*....|....*....|..
gi 157819159  97 GRVAVSG-DNAEPLLRAADLLQ 117
Cdd:cd18221   77 AKLMVQGeEEANDVWKAAEYLQ 98
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 30-99 3.05e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 58.47  E-value: 3.05e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157819159  30 AERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLH--------GVPPDMLQLLLDFSYTGRV 99
Cdd:cd18310   14 PDLFYSDAEIIVEGGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLElrelipggIVGYDAFMLVLSYLYSGRL 91
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-133 3.63e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 57.30  E-value: 3.63e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  41 AAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAErVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPA 120
Cdd:cd18349   18 PGASQRVPAHKYVLAVGSSVFYAMFYGDLAEVKSE-IHIPDVEPAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPA 96

                         90
                 ....*....|...
gi 157819159 121 VKEACGAFLQQQL 133
Cdd:cd18349   97 LAKACVNFLETSL 109
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-133 4.34e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 57.02  E-value: 4.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  48 PAHRAVLAAASPYFRAMFAGQLRESRAErVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGA 127
Cdd:cd18282   24 PAHKYVLATGSSVFYAMFYGGLAENKNE-IEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLARACVQ 102


                 ....*.
gi 157819159 128 FLQQQL 133
Cdd:cd18282  103 FLETSL 108
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-132 4.43e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 57.74  E-value: 4.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFS 94
Cdd:cd18325    4 PDHSRQLLQCLSQQRHQGFLCDCTV-LVGEAQFRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDIVTAPAFSLLLEFM 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 157819159  95 YTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQ 132
Cdd:cd18325   83 YEGKLEFSSLPVEDVLAAASYLHMYDIVKVCKGKLKDK 120
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-131 4.47e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 57.17  E-value: 4.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLEAAGgRDFPAHRAVLAAASPYFRamfaGQLRESRAERVRLHGV-PPDMLQLLLDFSY 95
Cdd:cd18200    1 YSSALLETLNKHRLEGKFCDLSVHVQG-RVFRAHKAVLAASSPYFH----DKLLLNDTNCLVLPSViEAAAFENLLQLIY 75

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157819159  96 TGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQ 131
Cdd:cd18200   76 SGRLTLCMDALPSHLLVASGLQMWQVVDRCSELLKE 111
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 327-368 4.84e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 54.93  E-value: 4.84e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 157819159  327 GYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWTEVAPM 368
Cdd:pfam01344   4 GAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-119 4.86e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 57.50  E-value: 4.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  16 AHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFA--GQLRESraeRVRLHGVPPDMLQLLLDF 93
Cdd:cd18212    5 THKDTVLTNFEEQRKKDFLCDITL-IVENVQFRAHKALLAASSEYFSMMFAdeGEVGQS---IYMLEGMVAETFGALLEF 80

                         90       100
                 ....*....|....*....|....*.
gi 157819159  94 SYTGRVAVSGDNAEPLLRAADLLQFP 119
Cdd:cd18212   81 IYTGCLQVGEKSLEQILATAQFLKVN 106
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-130 6.04e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 57.53  E-value: 6.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRaMFAGQLRESRaERVRLHG--VPPDMLQLLLD 92
Cdd:cd18323    4 PDHSRHLLQSLREQRHQGFLCDCTVLV-GSTQFLAHRAVLASCSPFFH-MFYKEQLDKR-DLVCINNeiVTAPAFSLLLE 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 157819159  93 FSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130
Cdd:cd18323   81 FMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVCKKRLQ 118
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-137 6.25e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 57.45  E-value: 6.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  48 PAHRAVLAAASPYFRAMFAGQLRESRAErVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGA 127
Cdd:cd18281   39 PAHKFVLSIGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVE 117

                         90
                 ....*....|
gi 157819159 128 FLQQQLDLAN 137
Cdd:cd18281  118 FLKKNLSSDN 127
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-151 6.78e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 57.74  E-value: 6.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFS 94
Cdd:cd18324    4 PDHSRHLLQCLSEQRHQGFLCDCTV-LVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFM 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 157819159  95 YTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDlANCLDMQDFAEAFSCS 151
Cdd:cd18324   83 YEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKAT-TEADSTKKEEDASSCS 138
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 133-210 1.23e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 54.82  E-value: 1.23e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGE-LGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADP 210
Cdd:cd18474    1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQaARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79
BTB_POZ_ARMC5 cd18191
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-129 1.58e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349500 [Multi-domain]  Cd Length: 100  Bit Score: 55.20  E-value: 1.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  36 DVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSY--TGRVAVSGDNAEPLLRAA 113
Cdd:cd18191    3 DLRFLLDGGTQLPASRAALTGASEVFRAMLEGGFAEAQQDLVPLRQVPSGAFLPVLHYLHgcRGCDANEDDEKSDQSPEG 82

                         90
                 ....*....|....*...
gi 157819159 114 DLLQFPA--VKEACGAFL 129
Cdd:cd18191   83 DLMKSSLgqTLEVAGRFL 100
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-125 1.87e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 55.74  E-value: 1.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRAERKFLDVTLEAAGGRdFPAHRAVLAAASPYFRAMfagqLRESRAERVRLHGVPPDMLQLLLDFS 94
Cdd:cd18334    2 PNHAKQLLLQLNQQRAKGFLCDVIIVVENAL-FRAHKNILAASSMYFKSL----VLHDNLINLDTDMVNPTVFRQILDFI 76

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 157819159  95 YTGRVAVSGDNAEP----LLRAADLLQFPAVKEAC 125
Cdd:cd18334   77 YTGKLLTSDQPGEQnfnaLLTAASYLQLHDLAALC 111
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-129 2.20e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 55.63  E-value: 2.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18331    7 HASDVLLNLNRLRSRDILTDVVI-VVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFNILLDFMYT 85

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAFL 129
Cdd:cd18331   86 SRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-134 2.28e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 55.73  E-value: 2.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  21 LLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLH--GVPPDMLQLLLDFSYTGR 98
Cdd:cd18201    8 LLQELNEQRKKGILCDVNI-VVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQTTVTHldVVAVQGFSVILDFMYSGN 86

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157819159  99 VAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLD 134
Cdd:cd18201   87 LVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-131 2.31e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 55.25  E-value: 2.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  20 SLLRGLSQLRAERKFLDVTLEAAGGRdFPAHRAVLAAASPYFRAMFAGQLRESRAERVrlhgVPPDMLQLLLDFSYTGRV 99
Cdd:cd18229    4 SLLETLNAQRLGGHFCDVTVRIHDAS-LRAHRCVLAAGSPFFHDKLLLGHSEIEVPPV----VPAQTVRQLVEFMYSGSL 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157819159 100 AVSGDNAEPLLRAADLLQFPAVKEACGAFLQQ 131
Cdd:cd18229   79 VVAQSEALQILTAASILQIKTVIDECTQIISQ 110
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 36-97 2.59e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 54.60  E-value: 2.59e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157819159  36 DVTLEAaGGRDFPAHRAVLAAASPYFRAMFAGQLRESRA----ERVRLHGVPPDMLQLLLDFSYTG 97
Cdd:cd18301   20 DVVFQV-GGKTFPAHKFILASRSDYFRKLFLSSLLTSEDavgcDVVHIEKVPPEIFEQLLQFIYTD 84
Kelch smart00612
Kelch domain;
337-382 2.93e-09

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 52.95  E-value: 2.93e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 157819159   337 IYVTGGSDGSRLYDCVWRYNSSVNEWTEVAPMLKAREYHSSSVLNG 382
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 135-225 2.96e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 54.25  E-value: 2.96e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 135 LANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRR 213
Cdd:cd18455    2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVsSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81

                         90
                 ....*....|..
gi 157819159 214 AAHWPQLLEAVR 225
Cdd:cd18455   82 KVHLKDLMSSCW 93
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 136-226 3.38e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 54.43  E-value: 3.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 136 ANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRA 214
Cdd:cd18464    3 SNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLrKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRH 82

                         90
                 ....*....|..
gi 157819159 215 AHWPQLLEAVRL 226
Cdd:cd18464   83 EVLPELLRSVRL 94
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-125 4.53e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 54.47  E-value: 4.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAER-VRLHGVPPDMLQLLLDFSY 95
Cdd:cd18202    2 HGQTVLDQLNQQRLNNQFCDVTL-LIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEAvVDLSGFCKSSFLPLLEFAY 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 157819159  96 TGRVAVSGDNAEPLLRAADLLQFPAVKEAC 125
Cdd:cd18202   81 TSELTFDFCSMAEVAMLARHLFMNEVLEIC 110
Kelch_6 pfam13964
Kelch motif;
502-549 4.64e-09

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 52.34  E-value: 4.64e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 157819159  502 HVGGSLAALGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEP 549
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTP 49
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-131 7.13e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 54.08  E-value: 7.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRAERKFLDVTLEAAGGRdFPAHRAVLAAASPYFRAMFAgqlrESRAERVRLHGVPPDMLQLLLDFS 94
Cdd:cd18216    1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSL-FRAHKNVLAASSGYFKSLVL----HDNLIHLDQDMVSPTVFQQILDFI 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 157819159  95 YTGRVAvSGDNAEP----LLRAADLLQFPAVKEACGAFLQQ 131
Cdd:cd18216   76 YTGKLL-DSLFEEPnlseVLAAANYLQLPDLAALCRSKLKR 115
PLN02193 PLN02193
nitrile-specifier protein
 327-451 8.26e-09

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 58.04  E-value: 8.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 327 GYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWTEVAPMLKA---REYHSSSVLNGLLYVVAADSTERYDHATDSWE 403
Cdd:PLN02193 221 GVRMVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGptpRSFHSMAADEENVYVFGGVSATARLKTLDSYN 300

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 157819159 404 ALQPMTY----PMDNCSTTA------CRGRLYAIGSLAGKETMVIQCYDPDTDLWSMV 451
Cdd:PLN02193 301 IVDKKWFhcstPGDSFSIRGgaglevVQGKVWVVYGFNGCEVDDVHYYDPVQDKWTQV 358
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 133-226 9.13e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 52.96  E-value: 9.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELG-AEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADpP 211
Cdd:cd18470    1 INVENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSeTDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-Q 79

                         90
                 ....*....|....*
gi 157819159 212 RRAAHWPQLLEAVRL 226
Cdd:cd18470   80 KRVKYAADLLSNIRF 94
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 133-226 1.04e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 53.20  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPP 211
Cdd:cd18462    1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVwQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                         90
                 ....*....|....*
gi 157819159 212 RRAAHWPQLLEAVRL 226
Cdd:cd18462   81 KRIECAYDLLSSIKL 95
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-123 1.10e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 52.91  E-value: 1.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  14 DPAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMF--AGQLresraerVRLHGVPPDMLQLLL 91
Cdd:cd18219    1 DTQYSGSLLKSLNEQRGHGLFCDVTV-IVEDRKFRAHKNILSASSTYFHQLFsvAGQV-------VELNFIRADIFAEIL 72

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157819159  92 DFSYTGR-VAVSGDNAEPLLRAADLLQFPAVKE 123
Cdd:cd18219   73 NYIYSSKiVRVRSDLLEELIKSGQLLGVKFIAE 105
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-137 1.11e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 53.91  E-value: 1.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  41 AAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAErVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPA 120
Cdd:cd18346   38 GPGAQRIPAHRFVLAAGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPA 116

                         90
                 ....*....|....*..
gi 157819159 121 VKEACGAFLQQQLDLAN 137
Cdd:cd18346  117 LEAHCVEFLTKHLRADN 133
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-130 1.57e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 52.97  E-value: 1.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRaervrlhgvppDMLQL------- 89
Cdd:cd18233    1 HSCHLLQQLHEQRIQGLLCDCML-VVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKN-----------DVFHLdiknvgg 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 157819159  90 ---LLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130
Cdd:cd18233   69 igqILDFMYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-101 2.24e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 52.57  E-value: 2.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAErVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18209    1 HAISLLSALNEERLKGQLCDVLL-IVGDQKFRAHKNVLAASSEYFQSLFTEKENESQSV-FQLDFCEPDAFENVLNYIYS 78


                 ....*
gi 157819159  97 GRVAV 101
Cdd:cd18209   79 SSLFV 83
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 133-225 3.00e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 51.77  E-value: 3.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGA-EQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPP 211
Cdd:cd18477    1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKdEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                         90
                 ....*....|....
gi 157819159 212 RRAAHWPQLLEAVR 225
Cdd:cd18477   81 NRQKALPTVFESIR 94
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-131 3.10e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 51.99  E-value: 3.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  20 SLLRGLSQLRAERKFLDVTLEAAGGRdFPAHRAVLAAASPYFRAMFAGQLRESRAERVrlhgVPPDMLQLLLDFSYTGRV 99
Cdd:cd18208   11 SVLETLNEQRNRGHFCDVTVRIHGSM-LRAHRCVLAAGSPFFQDKLLLGYSDIEIPSV----VSVQSVQKLIDFMYSGVL 85

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157819159 100 AVSGDNAEPLLRAADLLQFPAVKEACGAFLQQ 131
Cdd:cd18208   86 RVSQSEALQILTAASILQIKTVIDECTRIVSQ 117
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-124 3.86e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 51.92  E-value: 3.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRglsQLRAERKF---LDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQlrESRAERVRLHGVPPDMLQLLLDF 93
Cdd:cd18193    4 HGLILLQ---QLNAQREFgflCDCTV-AIGDVYFKAHKSVLASFSNYFKMLFVHQ--TSECVRLKPTDIQPDIFSYLLHL 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157819159  94 SYTGRVAVSGDNAEPLLRAADLLQ-FPAVKEA 124
Cdd:cd18193   78 MYTGKMAPQLIDPVRLEQGIKFLHaYPLIQEA 109
PHA02713 PHA02713
hypothetical protein; Provisional
 10-428 5.06e-08

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 55.79  E-value: 5.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  10 LPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAG-QLRESRAERVRLHGVPPDMLQ 88
Cdd:PHA02713   1 MDIDDIKHNRRVVSNISNLLDDDILCDVIITIGDGEEIKAHKTILAAGSKYFRTLFTTpMIIRDLVTRVNLQMFDKDAVK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  89 LLLDFSYTGRvaVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL 168
Cdd:PHA02713  81 NIVQYLYNRH--ISSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMYHRLYEMSHIPIVKYIKRMLMSNIPTL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 169 -GAEQLERLPLARLLRYLR-DDGLCVPKEEAAYQLALRWVRADPPRRAahwpQLL------EAVRLPFVRRFYLLAHVEa 240
Cdd:PHA02713 159 iTTDAFKKTVFEILFDIIStNDNVYLYREGYKVTILLKWLEYNYITEE----QLLcilsciDIQNLDKKSRLLLYSNKT- 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 241 eplVARCPPCLRLLREardfqaaryDRHDRGPCPRMrprpstglaeiLVLVggCdQDCDELVTVDC---YNPQTGQWRYL 317
Cdd:PHA02713 234 ---INMYPSCIQFLLD---------NKQNRNIIPRQ-----------LCLV--C-HDTKYNVCNPCilvYNINTMEYSVI 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 318 AEFPDHLgGGYSIVALGNDIYVTGGSDGSRL-YDCVWRYNSSVNEWTEVAPMLKAREYHSSSVLNGLLYVVAAD------ 390
Cdd:PHA02713 288 STIPNHI-INYASAIVDNEIIIAGGYNFNNPsLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQngtnve 366

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 157819159 391 -STERYDHATDSWEALQPMTYPMDNCSTTACRGRLYAIG 428
Cdd:PHA02713 367 rTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIG 405
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-123 5.46e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 51.36  E-value: 5.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRaERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFS 94
Cdd:cd18192    2 PSHSSYVLQQLNNQR-EWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECFDLILQFM 80

                         90       100
                 ....*....|....*....|....*....
gi 157819159  95 YTGRVAVSGDNAEPLLRAADLLQFPAVKE 123
Cdd:cd18192   81 YLGKIMTAPSDFEQLKVAMNYLQLYYIPE 109
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 503-547 6.04e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 49.15  E-value: 6.04e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 157819159  503 VGGSLAALGGKLYVSGGYDNTFELSDvVEAYDPETRAWSVVGRLP 547
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQSLNS-VEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-127 7.70e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 51.37  E-value: 7.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAG-QLRESRAERVRLhgVPPDMLQLLLDFSY 95
Cdd:cd18224    9 HPNNLLKELNKCRLSETMCDVTI-VVGNRSFAAHKAVLACAAGYFQKLFLStELDVARTYVVDF--ITPANFEKVLSFIY 85

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157819159  96 TGRVAVSGDNAEPLLRAADLLQFPAVKEACGA 127
Cdd:cd18224   86 TSELFTDLINVGVIYEVAEKLGMEDLLKACHS 117
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 133-229 8.27e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 50.29  E-value: 8.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQ-LERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPP 211
Cdd:cd18465    1 MSVETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEdFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPS 80

                         90
                 ....*....|....*...
gi 157819159 212 RRAAHwPQLLEAVRLPFV 229
Cdd:cd18465   81 RRASA-SHVLCHIRFPLM 97
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-126 1.43e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 49.97  E-value: 1.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  36 DVTLEAAGgRDFPAHRAVLAAaSPYFRAMFAGQLRESRAERVRL----HGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLR 111
Cdd:cd18305   17 DITICALG-REWKLHKIYLCQ-SGYFASMFSGSWKESKETVINLeipdDNITVEALNVVFGSLYRDEIEIKPSRVVSILA 94

                         90
                 ....*....|....*
gi 157819159 112 AADLLQFPAVKEACG 126
Cdd:cd18305   95 AATLLQLDGLIQQCS 109
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-98 1.56e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 50.28  E-value: 1.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  16 AHALSLLRglsQLRAERKF---LDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQlrESRAERVRLHGVPPDMLQLLLD 92
Cdd:cd18213    3 SHSLVLLQ---QLNMQREFgflCDCTV-AIGDVYFKAHRAVLAAFSNYFKMIFIHQ--SSECIKIQPTDIQPDIFSYLLH 76


                 ....*.
gi 157819159  93 FSYTGR 98
Cdd:cd18213   77 IMYTGK 82
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 133-229 1.71e-07

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 49.78  E-value: 1.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPP 211
Cdd:cd18466    1 IDPANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVqSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVG 80

                         90
                 ....*....|....*...
gi 157819159 212 RRAAHWPQLLEAVRLPFV 229
Cdd:cd18466   81 KRKKHVVEVLEPVRFPLL 98
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-129 1.96e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 50.05  E-value: 1.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHG--VPPDMLQLLLD 92
Cdd:cd18196    2 PGHFEQIFQQLNYQRLHGQLCDCVI-VVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSevVTAEAFAALID 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 157819159  93 FSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFL 129
Cdd:cd18196   81 MMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYL 117
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 136-226 2.16e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 49.07  E-value: 2.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 136 ANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRA 214
Cdd:cd18514    4 SNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVrESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLEKRK 83

                         90
                 ....*....|..
gi 157819159 215 AHWPQLLEAVRL 226
Cdd:cd18514   84 DYLPELLRNVRL 95
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 134-187 2.86e-07

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 47.27  E-value: 2.86e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 157819159 134 DLANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRD 187
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVsKSEEFLELSVELLLELLSS 55
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-137 3.21e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 49.63  E-value: 3.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  42 AGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAErVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAV 121
Cdd:cd18348   32 GGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDE-IRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHL 110

                         90
                 ....*....|....*.
gi 157819159 122 KEACGAFLQQQLDLAN 137
Cdd:cd18348  111 ARACVNFLETSLSAKN 126
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 133-225 3.36e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 48.61  E-value: 3.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQlERLPLA--RLLRYLRDDGLCVPKEEAAYQLALRWVRADP 210
Cdd:cd18517    1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEE-DFLQLAphELIAIISSDSLNVEKEELVFEAVMKWVRTDK 79

                         90
                 ....*....|....*
gi 157819159 211 PRRAAHWPQLLEAVR 225
Cdd:cd18517   80 ENRVKSLGEIFDCIR 94
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 133-227 3.55e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 48.70  E-value: 3.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQlERLPLAR--LLRYLRDDGLCVPKEEAAYQLALRWVRADP 210
Cdd:cd18483    1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQ-EFLHLTKdqLISILNSDDLNVEKEEHVYESIIHWFEHEQ 79

                         90
                 ....*....|....*...
gi 157819159 211 PRRAAHWPQLL-EAVRLP 227
Cdd:cd18483   80 SKREMHLPEIFaKCIRMP 97
BTB_POZ_BT cd18313
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-96 3.65e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349622 [Multi-domain]  Cd Length: 102  Bit Score: 48.63  E-value: 3.65e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157819159  36 DVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18313    3 DVEIETDNNSHIPAHSNVLASASPVIAGMLKQPRRKSSKKVIKILGVPCDAVRVFIRFLYS 63
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 137-226 5.47e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 48.05  E-value: 5.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 137 NCLDMQDFAEAFSCSGLASAAQRFILRHVGELG-AEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAA 215
Cdd:cd18515    4 NCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICkTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRHC 83

                         90
                 ....*....|.
gi 157819159 216 HWPQLLEAVRL 226
Cdd:cd18515   84 YLSELLQTVRL 94
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 36-114 5.56e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 47.71  E-value: 5.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  36 DVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQlRESRAE---RVRLHGVPPDMLQLLLDFSYTGRVAVSG---DNAEPL 109
Cdd:cd18283    4 DVDL-VFQGTCFPVHRAILSARCPFFRDLLSSS-PGYGAEipvDLPTAGIDVPMFSALLRYLYTGEFGSEDsrsQNLDVL 81


                 ....*
gi 157819159 110 LRAAD 114
Cdd:cd18283   82 IQLSE 86
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-137 9.03e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 48.15  E-value: 9.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  43 GGRDFPAHRAVLAAASPYFRAMFAGQLRESRAErVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVK 122
Cdd:cd18347   34 GSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALE 112

                         90
                 ....*....|....*
gi 157819159 123 EACGAFLQQQLDLAN 137
Cdd:cd18347  113 AHCVEFLKKNLRADN 127
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-125 9.29e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 47.98  E-value: 9.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  15 PAHALSLLRGLSQLRAERKFLDVTLEAAGGRdFPAHRAVLAAASPYFRAMFAgqlrESRAERVRLHGVPPDMLQLLLDFS 94
Cdd:cd18333    2 PSHSRQLLLQLNTQRTKGFLCDVIIVVQNAL-FRAHKNILAASSVYLKSLVV----HDNLINLDHEMVSPGIFRLILDYI 76

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 157819159  95 YTGRVAVSGDNAEP----LLRAADLLQFPAVKEAC 125
Cdd:cd18333   77 YTGRLSEGDPGSEQnlgaVLAAASYLQIPDLVALC 111
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 43-113 9.72e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 46.74  E-value: 9.72e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157819159  43 GGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRL--HGVPPDMLQLLLDFSYTGRV-AVSGDNAEPLLRAA 113
Cdd:cd18190    7 GGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFeeNGISIEAMRAVIDFSVTGRLdLFSVENVHEVLELA 80
BTB_POZ_KBTBD13 cd18320
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-130 9.85e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349629 [Multi-domain]  Cd Length: 83  Bit Score: 46.65  E-value: 9.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  43 GGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPD----MLQLLldfsytgrvavsgDNAEPLLRAADLLQf 118
Cdd:cd18320    9 EEQLFTVDKALLVENSEYFRALFRSGMRECTQDEIRLQGLSARgfriMLRVL-------------AGERPILNGEEILQ- 74

                         90
                 ....*....|..
gi 157819159 119 pAVKeaCGAFLQ 130
Cdd:cd18320   75 -AIE--CAAFLQ 83
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-125 1.16e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 47.90  E-value: 1.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  10 LPFSDPAHALSLLRGLSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAgqLRESRAERVRLHGVPPDMLQL 89
Cdd:cd18214    1 LHFRFENYGDSMLQKMNKLREQNKFCDVTVHI-DDLEVPGHKVVFAAGSPFLRDQFL--LNDSREVQISILQNSEVGRQL 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157819159  90 LLDfSYTGRVAVSGDNAEPLLRAADLLQFPAVKEAC 125
Cdd:cd18214   78 LLS-CYTGVLEFPEMELVNYLTAASFLQMSHIVERC 112
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 44-133 1.29e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 47.15  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  44 GRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGD-NAEPLLRAADLLQFPAVK 122
Cdd:cd18360   19 GTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTDSCCPASIlQAMALLICAEMYQVSRLQ 98

                         90
                 ....*....|.
gi 157819159 123 EACGAFLQQQL 133
Cdd:cd18360   99 HICELYIITQL 109
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-125 1.49e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 47.34  E-value: 1.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLEAAGGRdFPAHRAVLAAASPYFRAMFAgQLRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18204    1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVK-FRAHRCVLAACSTYFKKLFK-KLEVDSSSVIEIDFLRSDIFEEVLNYMYT 78

                         90       100
                 ....*....|....*....|....*....
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEAC 125
Cdd:cd18204   79 AKISVKKEDVNLMMSSGQILGIRFLDKLC 107
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-125 1.99e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 46.57  E-value: 1.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMFagqlrESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18205    1 HPTGLLHKANQMRLAGTLCDVVI-MVDSQEFHAHRTVLACTSKMFEILF-----HRNSQHYTLDFLSPKTFQQILEYAYT 74

                         90       100
                 ....*....|....*....|....*....
gi 157819159  97 GRVAVSGDNAEPLLRAADLLQFPAVKEAC 125
Cdd:cd18205   75 ATLQAKVEDLDDLLYAAEILEIEYLEEQC 103
Kelch smart00612
Kelch domain;
513-558 2.11e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 44.86  E-value: 2.11e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 157819159   513 KLYVSGGYDNTfELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSI 558
Cdd:smart00612   1 KIYVVGGFDGG-QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
Kelch_6 pfam13964
Kelch motif;
327-372 4.43e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 43.86  E-value: 4.43e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 157819159  327 GYSIVALGNDIYVTGG-SDGSRLYDCVWRYNSSVNEWTEVAPMLKAR 372
Cdd:pfam13964   4 FHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_3 pfam13415
Galactose oxidase, central domain;
334-380 6.11e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.43  E-value: 6.11e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 157819159  334 GNDIYVTGGSDGSR--LYDCVWRYNSSVNEWTEVAPMLKAREYHSSSVL 380
Cdd:pfam13415   1 GDKLYIFGGLGFDGqtRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 137-226 1.06e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 44.28  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 137 NCLDMQDFAEAFSCSGLASAAQRFIlRHVGELGAEQLERLPLAR--LLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRA 214
Cdd:cd18479    5 NCVRLLSFADLFSCEELKQSAKRMV-EHKFTAVYHQEAFMQLSHdlLIDILSSDNLNVEKEETVREAAMLWLEYNTESRS 83

                         90
                 ....*....|..
gi 157819159 215 AHWPQLLEAVRL 226
Cdd:cd18479   84 QYLSSVLSQIRI 95
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 137-225 1.37e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 44.12  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 137 NCLDMQDFAEAFSCSGLASAAQRFILRHVGEL---GAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPprR 213
Cdd:cd18471    5 NYLDLYKLADLFNLTLLEEAVVDFLVKHLSELlksHPEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHNC--R 82

                         90
                 ....*....|..
gi 157819159 214 AAHWPQLLEAVR 225
Cdd:cd18471   83 YQYMDELLQYVR 94
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 133-226 1.46e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 43.98  E-value: 1.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGA-EQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPP 211
Cdd:cd18516    1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARdEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQE 80

                         90
                 ....*....|....*
gi 157819159 212 RRAAHWPQLLEAVRL 226
Cdd:cd18516   81 ERTKALPVLLESIRF 95
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-140 1.54e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 44.97  E-value: 1.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  36 DVTLeAAGGRDFPAHRAVLAAASPYFRAMFAGQlRESRAERVRLHGVPPDMLQLLLDFSYTG---RVAVSGDNAEPLLRA 112
Cdd:cd18351   26 DVTF-LVEGRPFYAHKVLLFTASPRFKALLSNK-PSAENTCIEISYVKYHIFQLVMQYLYCGgteSLLIKNNEIMELLSA 103

                         90       100
                 ....*....|....*....|....*...
gi 157819159 113 ADLLQFPAVKEACGAFLQQQLDLANCLD 140
Cdd:cd18351  104 AKFFQLEALQRHCEIICAKSINTENCVD 131
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-113 2.22e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 44.01  E-value: 2.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  17 HALSLLRGLSQLRAERKFLDVTLEAAGGRdFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18223    1 HSDTVLSCLNEQRIQGILCDVTIVVEDTK-FKAHKNVLAASSLYFKNAFSSQEIWISSHVLELPDLKAEVFAEILNFIYS 79

                         90
                 ....*....|....*..
gi 157819159  97 GRVAVSGDNAEPLLRAA 113
Cdd:cd18223   80 SKVVVKRQETVTDLVAA 96
PLN02153 PLN02153
epithiospecifier protein
 327-451 2.35e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 46.90  E-value: 2.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 327 GYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWT-------EVAPmlKAREYHSSSVLNGLLYVVAADST------- 392
Cdd:PLN02153  78 GVRMVAVGTKLYIFGGRDEKREFSDFYSYDTVKNEWTfltkldeEGGP--EARTFHSMASDENHVYVFGGVSKgglmktp 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 393 ------ERYDHATDSWEALQPmtyPMDN------CSTTACRGRLYAIGSLA------GK---ETMVIQCYDPDTDLWSMV 451
Cdd:PLN02153 156 erfrtiEAYNIADGKWVQLPD---PGENfekrggAGFAVVQGKIWVVYGFAtsilpgGKsdyESNAVQFFDPASGKWTEV 232
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 32-65 2.73e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 43.92  E-value: 2.73e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 157819159  32 RKFLDVTLeAAGGRDFPAHRAVLAAASPYFRAMF 65
Cdd:cd18309   18 GDFCDITL-LLDGHPIPAHKAILAARCSYFEAMF 50
BACK_KLHL36 cd18475
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...
 137-229 2.81e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350550  Cd Length: 100  Bit Score: 43.29  E-value: 2.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 137 NCLDMQDFAEAFSCSGLASAAQRFILRHVGELG--AEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRaDPPRRA 214
Cdd:cd18475    5 NYLYLQELASIYSLERLDSFIDSFILQNFGTLSftPDFLQNVSMQKLCQYLSSNQVQHECEHDLLQAALQWLT-QSPERE 83

                         90
                 ....*....|....*
gi 157819159 215 AHWPQLLEAVRLPFV 229
Cdd:cd18475   84 NEAYQVLSNIHFPLI 98
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-116 3.44e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 43.25  E-value: 3.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  35 LDVTLEaagGRDFPAHRAVLAAASPYFRAMFAgqlRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAAD 114
Cdd:cd18226   25 LVITVE---GKEFSAHKVVVAVGSSYFHACLS---KNPNTDAVTLDHVSYSVFQHLLEFLYTSEFFVYENEIPLVLEAAK 98


                 ..
gi 157819159 115 LL 116
Cdd:cd18226   99 FL 100
BTB1_POZ_BTBD8 cd18285
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 21-96 4.68e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349594 [Multi-domain]  Cd Length: 104  Bit Score: 42.72  E-value: 4.68e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157819159  21 LLRGLSQLRAERKFLDVTLEAAGGRdFPAHRAVLAAASPYFRAMFAGQL-RESRAERVRLHGVPPDMLQLLLDFSYT 96
Cdd:cd18285    2 LSQDLLRLLREELHTDVTFYVGSTL-FKAHKAILLARVPEFFSHIIGKLsSLEDQEPINIENLEASEFKTFLRQVYT 77
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 133-225 5.64e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 42.41  E-value: 5.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLE-----RLPLARLLRYLRDDGLCVPKEEAAYQLALRWVR 207
Cdd:cd18473    1 LSPENCCFSANIAARFGLPDALKAAEKYIISNLWRLLASDADdagllELNLESLQAVLEADDIPRVKESRLLTLVLEWLN 80

                         90
                 ....*....|....*...
gi 157819159 208 ADpPRRAAHWPQLLEAVR 225
Cdd:cd18473   81 QD-ESRLAYANALLSRIR 97
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 21-117 6.01e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 42.57  E-value: 6.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  21 LLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMfaGQLRESRAERVRLHG-VPPDMLQLLLDFSYTGRV 99
Cdd:cd18311    1 FLQRLQNLFNKTEYCDLTLQFRDNEQLKVHRLVLSACTDYFNVL--EQTCEIVDDTLIMPNeLQADAVVPVINFMYTGQL 78

                         90
                 ....*....|....*...
gi 157819159 100 AVSGDNAEPLLRAADLLQ 117
Cdd:cd18311   79 EFEEKSYGKLLRTAKELN 96
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 133-217 7.60e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 41.48  E-value: 7.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGE-LGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPP 211
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKvIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*.
gi 157819159 212 RRAAHW 217
Cdd:cd18451   81 ERERYF 86
Kelch_4 pfam13418
Galactose oxidase, central domain;
327-368 8.06e-05

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 40.29  E-value: 8.06e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 157819159  327 GYSIVALGND-IYVTGG--SDGSRLYDCvWRYNSSVNEWTEVAPM 368
Cdd:pfam13418   4 YHTSTSIPDDtIYLFGGegEDGTLLSDL-WVFDLSTNEWTRLGSL 47
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-125 1.06e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 42.16  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159  20 SLLRGLSQLRAERKFLDVTLEAaGGRDFPAHRAVLAAASPYFRAMFAgqLRESRAERVRLHGVPPDMLQLLLDfSYTGRV 99
Cdd:cd18197   11 AVLQKMNLLRQQNLFCDVSIYI-NDTEFHGHKVILAACSTFMRDQFL--LNQSKQVRITILQSAEVGRKLLLS-CYTGAL 86

                         90       100
                 ....*....|....*....|....*.
gi 157819159 100 AVSGDNAEPLLRAADLLQFPAVKEAC 125
Cdd:cd18197   87 EVKKKELLKYLTAASYLQMVHIVEKC 112
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 504-546 1.25e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 39.63  E-value: 1.25e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 157819159  504 GGSLAALGGKLYVSGGYDNTF-ELSDVVEAYDPETRAWSVVGRL 546
Cdd:pfam07646   4 PHASSVPGGKLYVVGGSDGLGdLSSSDVLVYDPETNVWTEVPRL 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 371-409 4.03e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.36  E-value: 4.03e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 157819159  371 AREYHSSSVLNGLLYVV-------AADSTERYDHATDSWEALQPMT 409
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIggfdgnqSLNSVEVYDPETNTWSKLPSMP 46
PRK14131 PRK14131
N-acetylneuraminate epimerase;
308-382 6.19e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 42.31  E-value: 6.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 308 NPQTGQWRYLAEFPdhlGG---GYSIVALGNDIYVTGG-----SDGS-RLYDCVWRYNSSVNEWTEV---APMLKAReyH 375
Cdd:PRK14131  58 NAPSKGWTKIAAFP---GGpreQAVAAFIDGKLYVFGGigktnSEGSpQVFDDVYKYDPKTNSWQKLdtrSPVGLAG--H 132


                 ....*..
gi 157819159 376 SSSVLNG 382
Cdd:PRK14131 133 VAVSLHN 139
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 135-227 9.34e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 38.56  E-value: 9.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 135 LANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAE-QLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPrR 213
Cdd:cd18449    3 LENCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTgDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHEDD-R 81

                         90
                 ....*....|....
gi 157819159 214 AAHWPQLLEAVRLP 227
Cdd:cd18449   82 MQFAAKLMENIRFP 95
Kelch smart00612
Kelch domain;
383-422 1.69e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.38  E-value: 1.69e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 157819159   383 LLYVV-------AADSTERYDHATDSWEALQPMTYPMDNCSTTACRG 422
Cdd:smart00612   1 KIYVVggfdggqRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB2_POZ_BTBD7 cd18284
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 46-102 2.61e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349593  Cd Length: 146  Bit Score: 38.48  E-value: 2.61e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157819159  46 DFPAHRAVLAAASPYFRAMFAGQLRES--RAERVRLHGV------PPDMLQLLLDFSYTGRVAVS 102
Cdd:cd18284   29 ELRCHKAILSARSPFFRNLLQRRIRTGedRTLSTPTRIVldesiiPRRYARVLLHAMYTDSVDLS 93
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 286-321 2.92e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.05  E-value: 2.92e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 157819159  286 EILVLVGGCDQDCdELVTVDCYNPQTGQWRYLAEFP 321
Cdd:pfam01344  12 GKIYVIGGFDGNQ-SLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-114 3.25e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 37.62  E-value: 3.25e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157819159  43 GGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAAD 114
Cdd:cd18298   20 DGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPPEDAIGLLDLAN 91
Kelch_3 pfam13415
Galactose oxidase, central domain;
511-558 3.32e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 35.73  E-value: 3.32e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 157819159  511 GGKLYVSGGYD-NTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSI 558
Cdd:pfam13415   1 GDKLYIFGGLGfDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 30-104 4.97e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 37.64  E-value: 4.97e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157819159  30 AERKFLDVTLEAAGGrDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGD 104
Cdd:cd18358   16 SKGTFSDVTFKLDDG-TINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQLSPTAD 89
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 133-229 6.15e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 36.66  E-value: 6.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819159 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELG-AEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRW------ 205
Cdd:cd18461    1 VDEENILDVYKLADLFHLTHLSEQLDSYILKNFPTFSrTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLYhytpeq 80

                         90       100
                 ....*....|....*....|....*.
gi 157819159 206 VRAD--PPRRAahwPQLLEAVRLPFV 229
Cdd:cd18461   81 VEKDqvSLQEP---PKLLEAVRFPLM 103
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 414-451 7.53e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 34.90  E-value: 7.53e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 157819159  414 NCSTTACRGRLYAIGSLAGKETM-VIQCYDPDTDLWSMV 451
Cdd:pfam01344   4 GAGVVVVGGKIYVIGGFDGNQSLnSVEVYDPETNTWSKL 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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