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Conserved domains on  [gi|157817121|ref|NP_001101676|]
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dynein regulatory complex subunit 5 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 10061432)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 177-484 1.94e-76

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


:

Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 242.65  E-value: 1.94e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 177 DLVPLCRNYVRRIHVDQFLPPVRMPTPPQGEEQSDSGSEGEGNEPEKNHYQ-LQALVGGLKYLEELDlvYGVKDCGMNFE 255
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPsLKELCLSLNETGRIP--RGLQSLLQGLT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 256 --WNLFLFTYRDCHS---LAATIKACH---TLKIFRLTRSKVDDDKARILIRSLLDH-PALEELDLSHNLIGDRGARAAA 326
Cdd:cd00116   79 kgCGLQELDLSDNALgpdGCGVLESLLrssSLQELKLNNNGLGDRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 327 KLLSH-SRLRVLNLANNQLRASGAQSLAHALAHNTNLVSLNLRLNCIEDEGGQAIAHALETNKCLTVLNLGGNELSE-PT 404
Cdd:cd00116  159 KALRAnRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDaGA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 405 ATLLSQVLPVNTTLISLNLSCNHIGQDGGKQLLEGMSDNKTILEFDLRLSDVAQESEYLIGQVLHNNREaaRQRTLSPGH 484
Cdd:cd00116  239 AALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGN--ELESLWVKD 316
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 177-484 1.94e-76

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 242.65  E-value: 1.94e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 177 DLVPLCRNYVRRIHVDQFLPPVRMPTPPQGEEQSDSGSEGEGNEPEKNHYQ-LQALVGGLKYLEELDlvYGVKDCGMNFE 255
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPsLKELCLSLNETGRIP--RGLQSLLQGLT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 256 --WNLFLFTYRDCHS---LAATIKACH---TLKIFRLTRSKVDDDKARILIRSLLDH-PALEELDLSHNLIGDRGARAAA 326
Cdd:cd00116   79 kgCGLQELDLSDNALgpdGCGVLESLLrssSLQELKLNNNGLGDRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 327 KLLSH-SRLRVLNLANNQLRASGAQSLAHALAHNTNLVSLNLRLNCIEDEGGQAIAHALETNKCLTVLNLGGNELSE-PT 404
Cdd:cd00116  159 KALRAnRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDaGA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 405 ATLLSQVLPVNTTLISLNLSCNHIGQDGGKQLLEGMSDNKTILEFDLRLSDVAQESEYLIGQVLHNNREaaRQRTLSPGH 484
Cdd:cd00116  239 AALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGN--ELESLWVKD 316
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 266-486 5.38e-35

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 135.69  E-value: 5.38e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 266 CHSLAATIKACHTLKIFRLTRSKVDDDKARILIRSLLDHPALEELDLSHNLIGDRGARAAAKLLSH-SRLRVLNLANNQL 344
Cdd:COG5238  197 IEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNnTTVETLYLSGNQI 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 345 RASGAQSLAHALAHNTNLVSLNLRLNCIEDEGGQAIAHALETNKCLTVLNLGGNELSEPTATLLSQVLPVNTTLISLNLS 424
Cdd:COG5238  277 GAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLS 356

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157817121 425 CNHIGQDGGKQLLEGMSDNKTILEFDLRLSDV-AQESEYLIGQVLHNNreaARQRTLSPGHLT 486
Cdd:COG5238  357 DNQIGDEGAIALAKYLEGNTTLRELNLGKNNIgKQGAEALIDALQTNR---LHTLILDGNLIG 416
LRR_6 pfam13516
Leucine Rich repeat;
358-381 1.31e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 38.76  E-value: 1.31e-04
                          10        20
                  ....*....|....*....|....
gi 157817121  358 HNTNLVSLNLRLNCIEDEGGQAIA 381
Cdd:pfam13516   1 SNTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
304-331 3.32e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 37.77  E-value: 3.32e-04
                           10        20
                   ....*....|....*....|....*...
gi 157817121   304 HPALEELDLSHNLIGDRGARAAAKLLSH 331
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 307-428 8.22e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.06  E-value: 8.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 307 LEELDLSHNLIGDRGARaaaKLLSHSRLRVLNLANNQLraSGaqSLAHALAHNTNLVSLNLRLNCIEDEggqaIAHALET 386
Cdd:PLN00113 477 LENLDLSRNQFSGAVPR---KLGSLSELMQLKLSENKL--SG--EIPDELSSCKKLVSLDLSHNQLSGQ----IPASFSE 545

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157817121 387 NKCLTVLNLGGNELSEPTATLLSQVlpvnTTLISLNLSCNHI 428
Cdd:PLN00113 546 MPVLSQLDLSQNQLSGEIPKNLGNV----ESLVQVNISHNHL 583
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 177-484 1.94e-76

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 242.65  E-value: 1.94e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 177 DLVPLCRNYVRRIHVDQFLPPVRMPTPPQGEEQSDSGSEGEGNEPEKNHYQ-LQALVGGLKYLEELDlvYGVKDCGMNFE 255
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPsLKELCLSLNETGRIP--RGLQSLLQGLT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 256 --WNLFLFTYRDCHS---LAATIKACH---TLKIFRLTRSKVDDDKARILIRSLLDH-PALEELDLSHNLIGDRGARAAA 326
Cdd:cd00116   79 kgCGLQELDLSDNALgpdGCGVLESLLrssSLQELKLNNNGLGDRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 327 KLLSH-SRLRVLNLANNQLRASGAQSLAHALAHNTNLVSLNLRLNCIEDEGGQAIAHALETNKCLTVLNLGGNELSE-PT 404
Cdd:cd00116  159 KALRAnRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDaGA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 405 ATLLSQVLPVNTTLISLNLSCNHIGQDGGKQLLEGMSDNKTILEFDLRLSDVAQESEYLIGQVLHNNREaaRQRTLSPGH 484
Cdd:cd00116  239 AALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGN--ELESLWVKD 316
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 266-486 5.38e-35

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 135.69  E-value: 5.38e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 266 CHSLAATIKACHTLKIFRLTRSKVDDDKARILIRSLLDHPALEELDLSHNLIGDRGARAAAKLLSH-SRLRVLNLANNQL 344
Cdd:COG5238  197 IEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNnTTVETLYLSGNQI 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 345 RASGAQSLAHALAHNTNLVSLNLRLNCIEDEGGQAIAHALETNKCLTVLNLGGNELSEPTATLLSQVLPVNTTLISLNLS 424
Cdd:COG5238  277 GAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLS 356

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157817121 425 CNHIGQDGGKQLLEGMSDNKTILEFDLRLSDV-AQESEYLIGQVLHNNreaARQRTLSPGHLT 486
Cdd:COG5238  357 DNQIGDEGAIALAKYLEGNTTLRELNLGKNNIgKQGAEALIDALQTNR---LHTLILDGNLIG 416
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 277-471 1.10e-30

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 123.75  E-value: 1.10e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 277 HTLKIFRLTRSKVDDDKARILIRSLLDHPALEELDLSHNLIGDRGARAAAKLLSHS-RLRVLNLANNQLRASGAQSLAHA 355
Cdd:COG5238  180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNkSLTTLDLSNNQIGDEGVIALAEA 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 356 LAHNTNLVSLNLRLNCIEDEGGQAIAHALETNKCLTVLNLGGNELSEPTATLLSQVLPVNTTLISLNLSCNHIGQDGGKQ 435
Cdd:COG5238  260 LKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIA 339

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 157817121 436 LLEGMSDNKTILEFDLRLSDVAQESEYLIGQVLHNN 471
Cdd:COG5238  340 LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGN 375
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 267-438 1.08e-28

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 117.97  E-value: 1.08e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 267 HSLAATIKACHTLKIFRLTRSKVDDDKARILIRSLLDHPALEELDLSHNLIGDRGARAAAKLLSHSR-LRVLNLANNQLR 345
Cdd:COG5238  254 IALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKtLHTLNLAYNGIG 333

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 346 ASGAQSLAHALAHNTNLVSLNLRLNCIEDEGGQAIAHALETNKCLTVLNLGGNELSEPTATLLSQVLPVNTtLISLNLSC 425
Cdd:COG5238  334 AQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDG 412

                        170
                 ....*....|...
gi 157817121 426 NHIGQDGGKQLLE 438
Cdd:COG5238  413 NLIGAEAQQRLEQ 425
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 307-472 3.45e-27

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 113.73  E-value: 3.45e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 307 LEELDLSHNLIGDRGARAAAK-LLSHSRLRVLNLANNQLRASGAQSLAHALAHNTNLVSLNLRLNCIEDEGGQAIAHALE 385
Cdd:COG5238  182 VETVYLGCNQIGDEGIEELAEaLTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALK 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 386 TNKCLTVLNLGGNELSEPTATLLSQVLPVNTTLISLNLSCNHIGQDGGKQLLEGMSDNKTILEFDLRLSDVAQESEYLIG 465
Cdd:COG5238  262 NNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALA 341


                 ....*..
gi 157817121 466 QVLHNNR 472
Cdd:COG5238  342 KALQENT 348
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 267-471 5.75e-22

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 98.32  E-value: 5.75e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 267 HSLAATIKACHTLKI-FRLTRSKVDDD---------KARILIRSLLDHPALEELDLSHNL--IGDRGARAAAKLLSHSRL 334
Cdd:COG5238  103 VALAETATAVATPPPdLRRIMAKTLEDslilylalpRRINLIQVLKDPLGGNAVHLLGLAarLGLLAAISMAKALQNNSV 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 335 RVLNLANNQLRASGAQSLAHALAHNTNLVSLNLRLNCIEDEGGQAIAHALETNKCLTVLNLGGNELSEPTATLLSQVLPV 414
Cdd:COG5238  183 ETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKN 262

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 157817121 415 NTTLISLNLSCNHIGQDGGKQLLEGMSDNKTILEFDLRLSDVAQESEYLIGQVLHNN 471
Cdd:COG5238  263 NTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGN 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 306-472 2.85e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.11  E-value: 2.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 306 ALEELDLSHNLIGDRGARAAAKLLSHSRlrvlNLANNQLRASGAQSLAHALAHNTNLvsLNLRLNCIEDEGGQAIAHALE 385
Cdd:COG5238  104 ALAETATAVATPPPDLRRIMAKTLEDSL----ILYLALPRRINLIQVLKDPLGGNAV--HLLGLAARLGLLAAISMAKAL 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 386 TNKCLTVLNLGGNELSEPTATLLSQVLPVNTTLISLNLSCNHIGQDGGKQLLEGMSDNKTILEFDLRLSDVAQESEYLIG 465
Cdd:COG5238  178 QNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALA 257


                 ....*..
gi 157817121 466 QVLHNNR 472
Cdd:COG5238  258 EALKNNT 264
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 230-358 3.22e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 59.03  E-value: 3.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 230 ALVGGL---KYLEELDLVY-GVKDCGMNFewnlflftyrdchsLAATIKACHTLKIFRLTRSKVDDDKARILIRSLLDHP 305
Cdd:COG5238  311 ALAEGLqgnKTLHTLNLAYnGIGAQGAIA--------------LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNT 376

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 157817121 306 ALEELDLSHNLIGDRGARAAAKLLSHSRLRVLNLANNQLRASGAQSLAHALAH 358
Cdd:COG5238  377 TLRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLIGAEAQQRLEQLLER 429
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
268-438 9.72e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.17  E-value: 9.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 268 SLAATIKACHTLKIFRLTRSKVDDdkariLIRSLLDHPALEELDLSHNLIGDrgarAAAKLLSHSRLRVLNLANNQLRas 347
Cdd:COG4886  150 DLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQITD----LPEPLGNLTNLEELDLSGNQLT-- 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 348 gaqSLAHALAHNTNLVSLNLRLNCIEDeggqaiAHALETNKCLTVLNLGGNELSE-PTATLLSQvlpvnttLISLNLSCN 426
Cdd:COG4886  219 ---DLPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQLTDlPPLANLTN-------LKTLDLSNN 282

                        170
                 ....*....|..
gi 157817121 427 HIGQDGGKQLLE 438
Cdd:COG4886  283 QLTDLKLKELEL 294
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
253-428 7.46e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 7.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 253 NFEWNLFLFTYRDCHSLAATIKACHTLKIFRLTRSKVDDDKARILIRSLLDHPALEELDLSHNligdrgaraaAKLLSHS 332
Cdd:COG4886   44 SLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN----------EELSNLT 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 333 RLRVLNLANNQLrasgaQSLAHALAHNTNLVSLNLRLNCIEDeggqaIAHALETNKCLTVLNLGGNELSEptatlLSQVL 412
Cdd:COG4886  114 NLESLDLSGNQL-----TDLPEELANLTNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTD-----LPEEL 178

                        170
                 ....*....|....*.
gi 157817121 413 PVNTTLISLNLSCNHI 428
Cdd:COG4886  179 GNLTNLKELDLSNNQI 194
LRR_6 pfam13516
Leucine Rich repeat;
358-381 1.31e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 38.76  E-value: 1.31e-04
                          10        20
                  ....*....|....*....|....
gi 157817121  358 HNTNLVSLNLRLNCIEDEGGQAIA 381
Cdd:pfam13516   1 SNTHLTTLDLSDNDIGDEGAEALA 24
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
268-476 2.87e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 2.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 268 SLAATIKACHTLKIFRLTRSKVDDdkarilIRSLLDHPALEELDLSHNLIGDrgaraAAKLLSHSRLRVLNLANNQLRAS 347
Cdd:COG4886  219 DLPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQLTD-----LPPLANLTNLKTLDLSNNQLTDL 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 348 GAQSLAHALAHNTNLVSLNLRLNCIEDEGGQAIAHALETNkcLTVLNLGGNELSEPTATLLSQVLPVNTTLISLNLSCNH 427
Cdd:COG4886  288 KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLL--LLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTL 365

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 157817121 428 IGQDGGKQLLEGMSDNKTILEFDLRLSDVAQESEYLIGQVLHNNREAAR 476
Cdd:COG4886  366 LLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
304-331 3.32e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 37.77  E-value: 3.32e-04
                           10        20
                   ....*....|....*....|....*...
gi 157817121   304 HPALEELDLSHNLIGDRGARAAAKLLSH 331
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 305-398 3.36e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 3.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 305 PALEELDLSHN-------LIGDRGARAAaklLSHSrLRVLNLANNQLRasgaqSLAhALAHNTNLVSLNLRLNCIEDegG 377
Cdd:cd21340   90 TNLEELHIENQrlppgekLTFDPRSLAA---LSNS-LRVLNISGNNID-----SLE-PLAPLRNLEQLDASNNQISD--L 157

                         90       100
                 ....*....|....*....|.
gi 157817121 378 QAIAHALETNKCLTVLNLGGN 398
Cdd:cd21340  158 EELLDLLSSWPSLRELDLTGN 178
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
331-358 1.73e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 35.85  E-value: 1.73e-03
                           10        20
                   ....*....|....*....|....*...
gi 157817121   331 HSRLRVLNLANNQLRASGAQSLAHALAH 358
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 307-428 8.22e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.06  E-value: 8.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817121 307 LEELDLSHNLIGDRGARaaaKLLSHSRLRVLNLANNQLraSGaqSLAHALAHNTNLVSLNLRLNCIEDEggqaIAHALET 386
Cdd:PLN00113 477 LENLDLSRNQFSGAVPR---KLGSLSELMQLKLSENKL--SG--EIPDELSSCKKLVSLDLSHNQLSGQ----IPASFSE 545

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157817121 387 NKCLTVLNLGGNELSEPTATLLSQVlpvnTTLISLNLSCNHI 428
Cdd:PLN00113 546 MPVLSQLDLSQNQLSGEIPKNLGNV----ESLVQVNISHNHL 583
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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