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Conserved domains on  [gi|157820769|ref|NP_001101817|]
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uncharacterized protein C1orf53 homolog [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF5522 pfam17653
Family of unknown function (DUF5522); This is a family of unknown function. Family members are ...
73-120 4.56e-24

Family of unknown function (DUF5522); This is a family of unknown function. Family members are found in Bacteria and Eukaryotes. In algae, this family is found on the N-terminal of diphthamide synthase family pfam01902 and is predicted to be a membrane transporter belonging to The ATP-binding Cassette (ABC) family. In nematoda, it is found on the N-terminal side of ribosomal protein family L14 pfam00238. It is also found on the N-terminal of Cob(I)alamin adenosyltransferase pfam01923 in other eukaryotes. Family members found in homo sapiens such as Swiss:Q5VUE5, have been shown to be highly expressed in 15 high-grade neuroendocrine tumor cell lines and YAP1-positive small-cell lung cancer cell lines as well as being up-regulated in two human Multiple Myloma cell lines in response to selective nuclear export inhibitor KPT-276. The HMM profile of this family reveals 4 highly conserved cysteines.


:

Pssm-ID: 435947  Cd Length: 48  Bit Score: 87.28  E-value: 4.56e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 157820769   73 LHRAACAAGQLSYLDPATGYVVLTRLAHLQRGACCGSACRHCPYGQVN 120
Cdd:pfam17653   1 AHPEALEEGKDYYLDPETGYMVFTEQYHLKRGYCCGNGCRHCPYGHKN 48
 
Name Accession Description Interval E-value
DUF5522 pfam17653
Family of unknown function (DUF5522); This is a family of unknown function. Family members are ...
73-120 4.56e-24

Family of unknown function (DUF5522); This is a family of unknown function. Family members are found in Bacteria and Eukaryotes. In algae, this family is found on the N-terminal of diphthamide synthase family pfam01902 and is predicted to be a membrane transporter belonging to The ATP-binding Cassette (ABC) family. In nematoda, it is found on the N-terminal side of ribosomal protein family L14 pfam00238. It is also found on the N-terminal of Cob(I)alamin adenosyltransferase pfam01923 in other eukaryotes. Family members found in homo sapiens such as Swiss:Q5VUE5, have been shown to be highly expressed in 15 high-grade neuroendocrine tumor cell lines and YAP1-positive small-cell lung cancer cell lines as well as being up-regulated in two human Multiple Myloma cell lines in response to selective nuclear export inhibitor KPT-276. The HMM profile of this family reveals 4 highly conserved cysteines.


Pssm-ID: 435947  Cd Length: 48  Bit Score: 87.28  E-value: 4.56e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 157820769   73 LHRAACAAGQLSYLDPATGYVVLTRLAHLQRGACCGSACRHCPYGQVN 120
Cdd:pfam17653   1 AHPEALEEGKDYYLDPETGYMVFTEQYHLKRGYCCGNGCRHCPYGHKN 48
 
Name Accession Description Interval E-value
DUF5522 pfam17653
Family of unknown function (DUF5522); This is a family of unknown function. Family members are ...
73-120 4.56e-24

Family of unknown function (DUF5522); This is a family of unknown function. Family members are found in Bacteria and Eukaryotes. In algae, this family is found on the N-terminal of diphthamide synthase family pfam01902 and is predicted to be a membrane transporter belonging to The ATP-binding Cassette (ABC) family. In nematoda, it is found on the N-terminal side of ribosomal protein family L14 pfam00238. It is also found on the N-terminal of Cob(I)alamin adenosyltransferase pfam01923 in other eukaryotes. Family members found in homo sapiens such as Swiss:Q5VUE5, have been shown to be highly expressed in 15 high-grade neuroendocrine tumor cell lines and YAP1-positive small-cell lung cancer cell lines as well as being up-regulated in two human Multiple Myloma cell lines in response to selective nuclear export inhibitor KPT-276. The HMM profile of this family reveals 4 highly conserved cysteines.


Pssm-ID: 435947  Cd Length: 48  Bit Score: 87.28  E-value: 4.56e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 157820769   73 LHRAACAAGQLSYLDPATGYVVLTRLAHLQRGACCGSACRHCPYGQVN 120
Cdd:pfam17653   1 AHPEALEEGKDYYLDPETGYMVFTEQYHLKRGYCCGNGCRHCPYGHKN 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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