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Conserved domains on  [gi|157823457|ref|NP_001102186|]
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DDB1- and CUL4-associated factor 4 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
369-470 2.35e-09

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.15  E-value: 2.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823457 369 HDSAVTSVQVFKEEQYLMASDMAGKIKLWDLRATKCVRQYEGH---VNEYAYLPlhmheeEG-ILVAVGQDCYTRIWSLH 444
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHtgaVRSVAFSP------DGkLLASGSADGTVRLWDLA 234

                         90       100
                 ....*....|....*....|....*.
gi 157823457 445 DARLLRTIPSPcptsKANIPSVAFSP 470
Cdd:COG2319  235 TGKLLRTLTGH----SGSVRSVAFSP 256
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 263-470 1.23e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 1.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823457 263 LFVSSHQGT----DQPGMLCSFRIPGA----WSCAWSLNvqANNCFSTGLSRRVLLTNVVTGHRQSYWT--NSDVLAQQF 332
Cdd:cd00200   24 LATGSGDGTikvwDLETGELLRTLKGHtgpvRDVAASAD--GTYLASGSSDKTIRLWDLETGECVRTLTghTSYVSSVAF 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823457 333 AVKTPLLFNGCRSGEIFAIDLRSPSQakgwKATQIFHDSAVTSVQVFKEEQYLMASDMAGKIKLWDLRATKCVRQYEGHV 412
Cdd:cd00200  102 SPDGRILSSSSRDKTIKVWDVETGKC----LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHT 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 157823457 413 NEYAYLPLhmHEEEGILVAVGQDCYTRIWSLHDARLLRTIPSpcptSKANIPSVAFSP 470
Cdd:cd00200  178 GEVNSVAF--SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG----HENGVNSVAFSP 229
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
369-470 2.35e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.15  E-value: 2.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823457 369 HDSAVTSVQVFKEEQYLMASDMAGKIKLWDLRATKCVRQYEGH---VNEYAYLPlhmheeEG-ILVAVGQDCYTRIWSLH 444
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHtgaVRSVAFSP------DGkLLASGSADGTVRLWDLA 234

                         90       100
                 ....*....|....*....|....*.
gi 157823457 445 DARLLRTIPSPcptsKANIPSVAFSP 470
Cdd:COG2319  235 TGKLLRTLTGH----SGSVRSVAFSP 256
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 315-442 5.62e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.34  E-value: 5.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823457 315 TGHrqsywtNSDVLAQQFAVKTPLLFNGCRSGEIFAIDLRSPSqakgWKATQIFHDSAVTSVQVFKEEQYLMASDMAGKI 394
Cdd:cd00200  174 TGH------TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK----CLGTLRGHENGVNSVAFSPDGYLLASGSEDGTI 243

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 157823457 395 KLWDLRATKCVRQYEGHVNE-YAylpLHMHEEEGILVAVGQDCYTRIWS 442
Cdd:cd00200  244 RVWDLRTGECVQTLSGHTNSvTS---LAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 263-470 1.23e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 1.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823457 263 LFVSSHQGT----DQPGMLCSFRIPGA----WSCAWSLNvqANNCFSTGLSRRVLLTNVVTGHRQSYWT--NSDVLAQQF 332
Cdd:cd00200   24 LATGSGDGTikvwDLETGELLRTLKGHtgpvRDVAASAD--GTYLASGSSDKTIRLWDLETGECVRTLTghTSYVSSVAF 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823457 333 AVKTPLLFNGCRSGEIFAIDLRSPSQakgwKATQIFHDSAVTSVQVFKEEQYLMASDMAGKIKLWDLRATKCVRQYEGHV 412
Cdd:cd00200  102 SPDGRILSSSSRDKTIKVWDVETGKC----LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHT 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 157823457 413 NEYAYLPLhmHEEEGILVAVGQDCYTRIWSLHDARLLRTIPSpcptSKANIPSVAFSP 470
Cdd:cd00200  178 GEVNSVAF--SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG----HENGVNSVAFSP 229
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
369-470 2.35e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.15  E-value: 2.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823457 369 HDSAVTSVQVFKEEQYLMASDMAGKIKLWDLRATKCVRQYEGH---VNEYAYLPlhmheeEG-ILVAVGQDCYTRIWSLH 444
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHtgaVRSVAFSP------DGkLLASGSADGTVRLWDLA 234

                         90       100
                 ....*....|....*....|....*.
gi 157823457 445 DARLLRTIPSPcptsKANIPSVAFSP 470
Cdd:COG2319  235 TGKLLRTLTGH----SGSVRSVAFSP 256
WD40 COG2319
WD40 repeat [General function prediction only];
344-470 3.04e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.15  E-value: 3.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823457 344 RSGEIFAIDLRSPSQAKGWKATQIFHDSAVTSVQVFKEEQYLMASDMAGKIKLWDLRATKCVRQYEGH---VNEYAYLPl 420
Cdd:COG2319   52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHtgaVRSVAFSP- 130

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 157823457 421 hmheeEG-ILVAVGQDCYTRIWSLHDARLLRTIPSPcptsKANIPSVAFSP 470
Cdd:COG2319  131 -----DGkTLASGSADGTVRLWDLATGKLLRTLTGH----SGAVTSVAFSP 172
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 315-442 5.62e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.34  E-value: 5.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823457 315 TGHrqsywtNSDVLAQQFAVKTPLLFNGCRSGEIFAIDLRSPSqakgWKATQIFHDSAVTSVQVFKEEQYLMASDMAGKI 394
Cdd:cd00200  174 TGH------TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK----CLGTLRGHENGVNSVAFSPDGYLLASGSEDGTI 243

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 157823457 395 KLWDLRATKCVRQYEGHVNE-YAylpLHMHEEEGILVAVGQDCYTRIWS 442
Cdd:cd00200  244 RVWDLRTGECVQTLSGHTNSvTS---LAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 263-470 1.23e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 1.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823457 263 LFVSSHQGT----DQPGMLCSFRIPGA----WSCAWSLNvqANNCFSTGLSRRVLLTNVVTGHRQSYWT--NSDVLAQQF 332
Cdd:cd00200   24 LATGSGDGTikvwDLETGELLRTLKGHtgpvRDVAASAD--GTYLASGSSDKTIRLWDLETGECVRTLTghTSYVSSVAF 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823457 333 AVKTPLLFNGCRSGEIFAIDLRSPSQakgwKATQIFHDSAVTSVQVFKEEQYLMASDMAGKIKLWDLRATKCVRQYEGHV 412
Cdd:cd00200  102 SPDGRILSSSSRDKTIKVWDVETGKC----LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHT 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 157823457 413 NEYAYLPLhmHEEEGILVAVGQDCYTRIWSLHDARLLRTIPSpcptSKANIPSVAFSP 470
Cdd:cd00200  178 GEVNSVAF--SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG----HENGVNSVAFSP 229
WD40 COG2319
WD40 repeat [General function prediction only];
369-470 1.83e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.46  E-value: 1.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823457 369 HDSAVTSVQVFKEEQYLMASDMAGKIKLWDLRATKCVRQYEGH---VNEYAYLPlhmheeEG-ILVAVGQDCYTRIWSLH 444
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHsgsVRSVAFSP------DGrLLASGSADGTVRLWDLA 276

                         90       100
                 ....*....|....*....|....*.
gi 157823457 445 DARLLRTIPSPcptsKANIPSVAFSP 470
Cdd:COG2319  277 TGELLRTLTGH----SGGVNSVAFSP 298
WD40 COG2319
WD40 repeat [General function prediction only];
369-470 2.03e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.46  E-value: 2.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823457 369 HDSAVTSVQVFKEEQYLMASDMAGKIKLWDLRATKCVRQYEGH---VNEYAYLPlhmheEEGILVAVGQDCYTRIWSLHD 445
Cdd:COG2319  287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHtgaVRSVAFSP-----DGKTLASGSDDGTVRLWDLAT 361

                         90       100
                 ....*....|....*....|....*
gi 157823457 446 ARLLRTIPSPcptsKANIPSVAFSP 470
Cdd:COG2319  362 GELLRTLTGH----TGAVTSVAFSP 382
WD40 COG2319
WD40 repeat [General function prediction only];
369-470 3.10e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 3.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823457 369 HDSAVTSVQVFKEEQYLMASDMAGKIKLWDLRATKCVRQYEGH---VNEYAYLPlhmheeEG-ILVAVGQDCYTRIWSLH 444
Cdd:COG2319  245 HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHsggVNSVAFSP------DGkLLASGSDDGTVRLWDLA 318

                         90       100
                 ....*....|....*....|....*.
gi 157823457 445 DARLLRTIPSPcptsKANIPSVAFSP 470
Cdd:COG2319  319 TGKLLRTLTGH----TGAVRSVAFSP 340
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 369-470 2.74e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.26  E-value: 2.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823457 369 HDSAVTSVQVFKEEQYLMASDMAGKIKLWDLRATKCVRQYEGH---VNEYAYLPLHMHeeegiLVAVGQDCYTRIWSLHD 445
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHtgpVRDVAASADGTY-----LASGSSDKTIRLWDLET 82

                         90       100
                 ....*....|....*....|....*
gi 157823457 446 ARLLRTIPSpcptSKANIPSVAFSP 470
Cdd:cd00200   83 GECVRTLTG----HTSYVSSVAFSP 103
WD40 COG2319
WD40 repeat [General function prediction only];
283-445 2.98e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 2.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823457 283 PGAWSCAWSLNVQAnnCFSTGLSRRVLLTNVVTGHRQSYWTNSDVLAQQFAVkTP---LLFNGCRSGEIFAIDLRSPSQA 359
Cdd:COG2319  247 GSVRSVAFSPDGRL--LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF-SPdgkLLASGSDDGTVRLWDLATGKLL 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823457 360 KGWKAtqifHDSAVTSVQVFKEEQYLMASDMAGKIKLWDLRATKCVRQYEGH---VNEYAYLPlhmheEEGILVAVGQDC 436
Cdd:COG2319  324 RTLTG----HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHtgaVTSVAFSP-----DGRTLASGSADG 394


                 ....*....
gi 157823457 437 YTRIWSLHD 445
Cdd:COG2319  395 TVRLWDLAT 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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