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Conserved domains on  [gi|182765445|ref|NP_001116824|]
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palmitoyl-protein thioesterase ABHD10, mitochondrial precursor [Rattus norvegicus]

Protein Classification

alpha/beta hydrolase( domain architecture ID 10787854)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917|37582413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
62-293 1.02e-20

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 88.85  E-value: 1.02e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445  62 LKGKNPGIIFIPGYLSNMNGKKAVAieEFCKSIGHAFIRFDYSGVGSSDGNLAECSVGKWRKDVLSILDDIAEG--PQIL 139
Cdd:COG1647   11 LEGGRKGVLLLHGFTGSPAEMRPLA--EALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILKAGydKVIV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445 140 VGSSLGGWLMLHAAIARPEkVIALIGIASATDGVVTQFHSLPVEMQ--KEIEMKGEWSLPSKYNKEGYYSIP-------Y 210
Cdd:COG1647   89 IGLSMGGLLALLLAARYPD-VAGLVLLSPALKIDDPSAPLLPLLKYlaRSLRGIGSDIEDPEVAEYAYDRTPlralaelQ 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445 211 SFIKEAAHHclLHSpipVTCPVRLLHGMKDEIVPWHRSLQVADRVVSPDVDVILRKHSDHRMKETADIHLLICTIDDLID 290
Cdd:COG1647  168 RLIREVRRD--LPK---ITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVITLDKDREEVAEEILDFLE 242


                 ...
gi 182765445 291 KLS 293
Cdd:COG1647  243 RLA 245
 
Name Accession Description Interval E-value
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
62-293 1.02e-20

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 88.85  E-value: 1.02e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445  62 LKGKNPGIIFIPGYLSNMNGKKAVAieEFCKSIGHAFIRFDYSGVGSSDGNLAECSVGKWRKDVLSILDDIAEG--PQIL 139
Cdd:COG1647   11 LEGGRKGVLLLHGFTGSPAEMRPLA--EALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILKAGydKVIV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445 140 VGSSLGGWLMLHAAIARPEkVIALIGIASATDGVVTQFHSLPVEMQ--KEIEMKGEWSLPSKYNKEGYYSIP-------Y 210
Cdd:COG1647   89 IGLSMGGLLALLLAARYPD-VAGLVLLSPALKIDDPSAPLLPLLKYlaRSLRGIGSDIEDPEVAEYAYDRTPlralaelQ 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445 211 SFIKEAAHHclLHSpipVTCPVRLLHGMKDEIVPWHRSLQVADRVVSPDVDVILRKHSDHRMKETADIHLLICTIDDLID 290
Cdd:COG1647  168 RLIREVRRD--LPK---ITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVITLDKDREEVAEEILDFLE 242


                 ...
gi 182765445 291 KLS 293
Cdd:COG1647  243 RLA 245
PLN02578 PLN02578
hydrolase
 28-169 5.18e-07

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 50.22  E-value: 5.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445  28 ARKPPWAWWLSACRQKTTLSFLKRPElpSLAYKR----------------LKGKNPGIIFIPGYlsnmnGKKAV----AI 87
Cdd:PLN02578  34 IFGGIVASGVSVMGSSSASQSVQGLE--RLPFKKegynfwtwrghkihyvVQGEGLPIVLIHGF-----GASAFhwryNI 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445  88 EEFCKSigHAFIRFDYSGVGSSDGNLAECSVGKWRKDVLSILDDIAEGPQILVGSSLGGWLMLHAAIARPEKVIALIGIA 167
Cdd:PLN02578 107 PELAKK--YKVYALDLLGFGWSDKALIEYDAMVWRDQVADFVKEVVKEPAVLVGNSLGGFTALSTAVGYPELVAGVALLN 184


                 ..
gi 182765445 168 SA 169
Cdd:PLN02578 185 SA 186
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
141-281 1.68e-05

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 44.91  E-value: 1.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445  141 GSSLGGWLMLHAAIARPEKVIALIGIASATDgvVTQFHSLPVEMQKEIEMkgEWSLPsKYNKEGY-YSIPYSFIKEaahh 219
Cdd:pfam00326  70 GGSYGGYLTGAALNQRPDLFKAAVAHVPVVD--WLAYMSDTSLPFTERYM--EWGNP-WDNEEGYdYLSPYSPADN---- 140

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 182765445  220 cllhspIPVTCPVRLLHGMKDEIVPWHRSLQVADRVVSPDVDVILR--KHSDHRM-KETADIHLL 281
Cdd:pfam00326 141 ------VKVYPPLLLIHGLLDDRVPPWQSLKLVAALQRKGVPFLLLifPDEGHGIgKPRNKVEEY 199
Esterase_713_like-1 cd12808
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated ...
 135-166 7.04e-05

Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.


Pssm-ID: 214007  Cd Length: 309  Bit Score: 43.77  E-value: 7.04e-05
                         10        20        30
                 ....*....|....*....|....*....|..
gi 182765445 135 GPQILVGSSLGGWLMLHAAIARPEKVIALIGI 166
Cdd:cd12808  188 GPCIVVAHSQGGGFAFEAARARPDLVRAVVAL 219
hydr2_PEP TIGR03101
exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha ...
 64-180 1.10e-03

exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 1, TIGR03100) of the same superfamily.


Pssm-ID: 274428  Cd Length: 266  Bit Score: 39.80  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445   64 GKNPGIIFIPGYLSNMN-GKKAVAI--EEFCKSiGHAFIRFDYSGVGSSDGNLAECSVGKWRKDVLSI---LDDIAEGPQ 137
Cdd:TIGR03101  23 GPRGVVIYLPPFAEEMNkSRRMVALqaRAFAAG-GFGVLQIDLYGCGDSAGDFAAARWDVWKEDVAAAyrwLIEQGHPPV 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 182765445  138 ILVGSSLGGWLMLHAAIARPEKVIALIGIASATDGVV--TQFHSL 180
Cdd:TIGR03101 102 TLWGLRLGALLALDAANPLAAKCNRLVLWQPVVSGKQqlQQFLRL 146
 
Name Accession Description Interval E-value
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
62-293 1.02e-20

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 88.85  E-value: 1.02e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445  62 LKGKNPGIIFIPGYLSNMNGKKAVAieEFCKSIGHAFIRFDYSGVGSSDGNLAECSVGKWRKDVLSILDDIAEG--PQIL 139
Cdd:COG1647   11 LEGGRKGVLLLHGFTGSPAEMRPLA--EALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILKAGydKVIV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445 140 VGSSLGGWLMLHAAIARPEkVIALIGIASATDGVVTQFHSLPVEMQ--KEIEMKGEWSLPSKYNKEGYYSIP-------Y 210
Cdd:COG1647   89 IGLSMGGLLALLLAARYPD-VAGLVLLSPALKIDDPSAPLLPLLKYlaRSLRGIGSDIEDPEVAEYAYDRTPlralaelQ 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445 211 SFIKEAAHHclLHSpipVTCPVRLLHGMKDEIVPWHRSLQVADRVVSPDVDVILRKHSDHRMKETADIHLLICTIDDLID 290
Cdd:COG1647  168 RLIREVRRD--LPK---ITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVITLDKDREEVAEEILDFLE 242


                 ...
gi 182765445 291 KLS 293
Cdd:COG1647  243 RLA 245
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
63-281 1.21e-16

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 77.36  E-value: 1.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445  63 KGKNPGIIFIPGYLSNMNGKKAVAIEEFCkSIGHAFIRFDYSGVGSSDGNLAecsvGKWRKDVLSILDDIAEGPQI---- 138
Cdd:COG1506   20 GKKYPVVVYVHGGPGSRDDSFLPLAQALA-SRGYAVLAPDYRGYGESAGDWG----GDEVDDVLAAIDYLAARPYVdpdr 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445 139 --LVGSSLGGWLMLHAAIARPEKVIALIGIASATDgVVTQFHSlpVEMQKEIEMKGEWSLPSKYNKegyysipYSFIKEA 216
Cdd:COG1506   95 igIYGHSYGGYMALLAAARHPDRFKAAVALAGVSD-LRSYYGT--TREYTERLMGGPWEDPEAYAA-------RSPLAYA 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 182765445 217 AHhcllhspipVTCPVRLLHGMKDEIVPWHRSLQVADRVVSPDVDVILR--KHSDHRMKETADIHLL 281
Cdd:COG1506  165 DK---------LKTPLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLvyPGEGHGFSGAGAPDYL 222
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 57-270 1.74e-16

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 76.58  E-value: 1.74e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445  57 LAYKRLKGKNPGIIFIPGYLSNMNGKKAVaIEEFCKsiGHAFIRFDYSGVGSSDGNLAECSVGKWRKDVLSILDDIAEGP 136
Cdd:COG0596   14 LHYREAGPDGPPVVLLHGLPGSSYEWRPL-IPALAA--GYRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDALGLER 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445 137 QILVGSSLGGWLMLHAAIARPEKVIALIGIASATDGVVTQFH---SLPVEMQKEIEMKGEWSLPSKYNKegyysipysfi 213
Cdd:COG0596   91 VVLVGHSMGGMVALELAARHPERVAGLVLVDEVLAALAEPLRrpgLAPEALAALLRALARTDLRERLAR----------- 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 182765445 214 keaahhcllhspipVTCPVRLLHGMKDEIVPWHRSLQVADRVvsPDVDVILRKHSDH 270
Cdd:COG0596  160 --------------ITVPTLVIWGEKDPIVPPALARRLAELL--PNAELVVLPGAGH 200
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
69-270 1.21e-14

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 71.57  E-value: 1.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445  69 IIFIPGYLSNMNGKKAVAiEEFCKSiGHAFIRFDYSGVGSSDGNLAEC-SVGKWRKDVLSILDDIAE---GPQILVGSSL 144
Cdd:COG2267   31 VVLVHGLGEHSGRYAELA-EALAAA-GYAVLAFDLRGHGRSDGPRGHVdSFDDYVDDLRAALDALRArpgLPVVLLGHSM 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445 145 GGWLMLHAAIARPEKVIALIGIASAtdgvvtqfhslpvemqkeiemkgewslpskYNKEGYYSIPYSFIKEAAHHCLLHS 224
Cdd:COG2267  109 GGLIALLYAARYPDRVAGLVLLAPA------------------------------YRADPLLGPSARWLRALRLAEALAR 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 182765445 225 pipVTCPVRLLHGMKDEIVPWHRSLQVADRvVSPDVDVILRKHSDH 270
Cdd:COG2267  159 ---IDVPVLVLHGGADRVVPPEAARRLAAR-LSPDVELVLLPGARH 200
PLN02578 PLN02578
hydrolase
 28-169 5.18e-07

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 50.22  E-value: 5.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445  28 ARKPPWAWWLSACRQKTTLSFLKRPElpSLAYKR----------------LKGKNPGIIFIPGYlsnmnGKKAV----AI 87
Cdd:PLN02578  34 IFGGIVASGVSVMGSSSASQSVQGLE--RLPFKKegynfwtwrghkihyvVQGEGLPIVLIHGF-----GASAFhwryNI 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445  88 EEFCKSigHAFIRFDYSGVGSSDGNLAECSVGKWRKDVLSILDDIAEGPQILVGSSLGGWLMLHAAIARPEKVIALIGIA 167
Cdd:PLN02578 107 PELAKK--YKVYALDLLGFGWSDKALIEYDAMVWRDQVADFVKEVVKEPAVLVGNSLGGFTALSTAVGYPELVAGVALLN 184


                 ..
gi 182765445 168 SA 169
Cdd:PLN02578 185 SA 186
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 63-258 1.87e-06

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 47.99  E-value: 1.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445  63 KGKNPGIIFIPGYLSN--MNGKKAVAIEEfcksIGHAFIRFDYSGVGSSDGNLAEcsVGK-WRKDV------LSILDDIA 133
Cdd:COG1073   34 SKKYPAVVVAHGNGGVkeQRALYAQRLAE----LGFNVLAFDYRGYGESEGEPRE--EGSpERRDAraavdyLRTLPGVD 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445 134 EGPQILVGSSLGGWLMLHAAIARPEkVIALIgiasaTDGVVTQFHSLPVEMQKEIEMKG--------EWSLPSKYNKEgy 205
Cdd:COG1073  108 PERIGLLGISLGGGYALNAAATDPR-VKAVI-----LDSPFTSLEDLAAQRAKEARGAYlpgvpylpNVRLASLLNDE-- 179

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 182765445 206 YSiPYSFIKEaahhcllhspipVTCPVRLLHGMKDEIVPWHRSLQVADRVVSP 258
Cdd:COG1073  180 FD-PLAKIEK------------ISRPLLFIHGEKDEAVPFYMSEDLYEAAAEP 219
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
63-270 1.34e-05

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 45.15  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445  63 KGKNPGIIFI----PGYLSNMNGKKAVAIEEFCKSIGHAFIRFDYSGVGSSDGNLAEcSVGKwRKDVLSILDDIAE---G 135
Cdd:COG2945   19 EGPPRGVALIlhphPLFGGTMDNKVVYTLARALVAAGFAVLRFNFRGVGRSEGEFDE-GRGE-LDDAAAALDWLRAqnpL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445 136 PQILVGSSLGGWLMLHAAIARPEkVIALIGIAsatdgvvtqfhsLPVEMQkeiemkgewslpskynkegyysiPYSFIKe 215
Cdd:COG2945   97 PLWLAGFSFGAYVALQLAMRLPE-VEGLILVA------------PPVNRY-----------------------DFSFLA- 139

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 182765445 216 aahhcllhspiPVTCPVRLLHGMKDEIVPWHRSLQVADRvVSPDVDVILRKHSDH 270
Cdd:COG2945  140 -----------PCPAPTLVIHGEQDEVVPPAEVLDWARP-LSPPLPVVVVPGADH 182
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
141-281 1.68e-05

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 44.91  E-value: 1.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445  141 GSSLGGWLMLHAAIARPEKVIALIGIASATDgvVTQFHSLPVEMQKEIEMkgEWSLPsKYNKEGY-YSIPYSFIKEaahh 219
Cdd:pfam00326  70 GGSYGGYLTGAALNQRPDLFKAAVAHVPVVD--WLAYMSDTSLPFTERYM--EWGNP-WDNEEGYdYLSPYSPADN---- 140

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 182765445  220 cllhspIPVTCPVRLLHGMKDEIVPWHRSLQVADRVVSPDVDVILR--KHSDHRM-KETADIHLL 281
Cdd:pfam00326 141 ------VKVYPPLLLIHGLLDDRVPPWQSLKLVAALQRKGVPFLLLifPDEGHGIgKPRNKVEEY 199
Esterase_713_like-1 cd12808
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated ...
 135-166 7.04e-05

Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.


Pssm-ID: 214007  Cd Length: 309  Bit Score: 43.77  E-value: 7.04e-05
                         10        20        30
                 ....*....|....*....|....*....|..
gi 182765445 135 GPQILVGSSLGGWLMLHAAIARPEKVIALIGI 166
Cdd:cd12808  188 GPCIVVAHSQGGGFAFEAARARPDLVRAVVAL 219
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 95-169 8.15e-05

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 43.78  E-value: 8.15e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 182765445  95 GHAFIRFDYSGVGSSDGNLAECSVGKWRKDVLSILDDIAEGPQILVGSSLGGWLMLHAAIARPEKVIALIGIASA 169
Cdd:PRK14875 157 GRPVIALDLPGHGASSKAVGAGSLDELAAAVLAFLDALGIERAHLVGHSMGGAVALRLAARAPQRVASLTLIAPA 231
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 95-270 1.02e-04

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 42.59  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445   95 GHAFIRFDYSGVGSSDGNLAEC-SVGKWRKDVLSILDDIAEG----PQILVGSSLGGWLMLHAAIARPEKVIALIGIASA 169
Cdd:pfam12146  31 GFAVYAYDHRGHGRSDGKRGHVpSFDDYVDDLDTFVDKIREEhpglPLFLLGHSMGGLIAALYALRYPDKVDGLILSAPA 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445  170 TDGVVTQFHSLPVEMQKEIEMKG-EWSLPSKYNKEGYYSIPySFIKEAAHHCLLHSPIPV-------------------- 228
Cdd:pfam12146 111 LKIKPYLAPPILKLLAKLLGKLFpRLRVPNNLLPDSLSRDP-EVVAAYAADPLVHGGISArtlyelldagerllrraaai 189

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 182765445  229 TCPVRLLHGMKDEIVPWHRSLQVADRVVSPDVDVILRKHSDH 270
Cdd:pfam12146 190 TVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYH 231
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 69-175 2.01e-04

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 42.11  E-value: 2.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445   69 IIFIPGYLSNMNG--KKAVAIEEfcksIGHAFIRFDYSGVGSSDGNLAECSVGKW--RKDVLSILDDIAEGPQILVGSSL 144
Cdd:pfam00561   3 VLLLHGLPGSSDLwrKLAPALAR----DGFRVIALDLRGFGKSSRPKAQDDYRTDdlAEDLEYILEALGLEKVNLVGHSM 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 182765445  145 GGWLMLHAAIARPEKVIALIGIASATDGVVT 175
Cdd:pfam00561  79 GGLIALAYAAKYPDRVKALVLLGALDPPHEL 109
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 69-277 4.75e-04

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 40.53  E-value: 4.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445   69 IIFIPGYlsnmnGKKAVAIEEFCKSiGHAFIRFDYSGVGSSDGNLAECSVgkwRKDVLSILDDIAEGPQ-ILVGSSLGGW 147
Cdd:pfam12697   1 VVLVHGA-----GLSAAPLAALLAA-GVAVLAPDLPGHGSSSPPPLDLAD---LADLAALLDELGAARPvVLVGHSLGGA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445  148 LMLHAAIARPEKVIAL------IGIASATDGVVTQFHSLPVEMQKEIEMKGEWSLPSKYNKEGYYSIPYSFIKEAAHHCL 221
Cdd:pfam12697  72 VALAAAAAALVVGVLVaplaapPGLLAALLALLARLGAALAAPAWLAAESLARGFLDDLPADAEWAAALARLAALLAALA 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 182765445  222 LHSPIP---VTCPVRLLHGMKDEIVPWHRSLQVAdrvvSPDVDVILRKHSDHRMKETAD 277
Cdd:pfam12697 152 LLPLAAwrdLPVPVLVLAEEDRLVPELAQRLLAA----LAGARLVVLPGAGHLPLDDPE 206
hydr2_PEP TIGR03101
exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha ...
 64-180 1.10e-03

exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 1, TIGR03100) of the same superfamily.


Pssm-ID: 274428  Cd Length: 266  Bit Score: 39.80  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 182765445   64 GKNPGIIFIPGYLSNMN-GKKAVAI--EEFCKSiGHAFIRFDYSGVGSSDGNLAECSVGKWRKDVLSI---LDDIAEGPQ 137
Cdd:TIGR03101  23 GPRGVVIYLPPFAEEMNkSRRMVALqaRAFAAG-GFGVLQIDLYGCGDSAGDFAAARWDVWKEDVAAAyrwLIEQGHPPV 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 182765445  138 ILVGSSLGGWLMLHAAIARPEKVIALIGIASATDGVV--TQFHSL 180
Cdd:TIGR03101 102 TLWGLRLGALLALDAANPLAAKCNRLVLWQPVVSGKQqlQQFLRL 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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