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Conserved domains on  [gi|189011652|ref|NP_001121000|]
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transmembrane protease serine 13 [Rattus norvegicus]

Protein Classification

SRCR_2 and Tryp_SPc domain-containing protein( domain architecture ID 12173813)

SRCR_2 and Tryp_SPc domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 297-526 2.99e-99

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


:

Pssm-ID: 214473  Cd Length: 229  Bit Score: 299.59  E-value: 2.99e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   297 RIVGGALTSESKWPWQVSLHF-GTTHICGGTLIDAQWVLTAAHCFfvtREKILEGWKVYAGTSNLHQLPEA--ASISQII 373
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYgGGRHFCGGSLISPRWVLTAAHCV---RGSDPSNIRVRLGSHDLSSGEEGqvIKVSKVI 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   374 INGNYTDEQDDYDIALVRLSKPLTLSAHIHPACLPLHGQTFGLNETCWITGFGKTKETDEKTSPFLREVQVNLIDFKKCN 453
Cdd:smart00020  78 IHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSNYNVPAGTTCTVSGWGRTSEGAGSLPDTLQEVNVPIVSNATCR 157

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189011652   454 DYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCeQNNRWYLAGVTSWGTGCGQKNKPGVYTKVTEVLPWI 526
Cdd:smart00020 158 RAYSGGGAITDNMLCAGGLEGGKDACQGDSGGPLVC-NDGRWVLVGIVSWGSGCARPGKPGVYTRVSSYLDWI 229
SRCR_2 pfam15494
Scavenger receptor cysteine-rich domain; SRCR_2 is a scavenger receptor cysteine-rich domain ...
 203-293 2.90e-26

Scavenger receptor cysteine-rich domain; SRCR_2 is a scavenger receptor cysteine-rich domain family found largely on vertebrate sequences up-stream of the trypsin-like transmembrane serine protease, Spinesin.


:

Pssm-ID: 464747  Cd Length: 99  Bit Score: 102.41  E-value: 2.90e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652  203 WDKSLLKVYSGSSGEWLPVCSSSWNDTDSERTCQQLGFDSAYRTTEVAHRDVTSSF-------LLSEYNSTIQESL-TRS 274
Cdd:pfam15494   1 GENFLLQVYSSARPSWLPVCSDDWNPAYGRAACQQLGYLRLTHHKSVNLTDISSNSsqsfmklNSSSLNTDLYEALqPRD 80

                          90
                  ....*....|....*....
gi 189011652  275 ECPSRRYVSLQCAHCGLRA 293
Cdd:pfam15494  81 SCSSGSVVSLRCSECGLRS 99
PHA03378 super family cl33729
EBNA-3B; Provisional
 11-122 4.93e-12

EBNA-3B; Provisional


The actual alignment was detected with superfamily member PHA03378:

Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 68.94  E-value: 4.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652  11 PARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPPSRSSSGRSSSARSASTTSSPT 90
Cdd:PHA03378 673 PYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPG 752

                         90       100       110
                 ....*....|....*....|....*....|..
gi 189011652  91 RVylvrAIPVGTVIRASPARSAPATRATRESP 122
Cdd:PHA03378 753 RA----RPPAAAPGRARPPAAAPGAPTPQPPP 780
 
Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 297-526 2.99e-99

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 299.59  E-value: 2.99e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   297 RIVGGALTSESKWPWQVSLHF-GTTHICGGTLIDAQWVLTAAHCFfvtREKILEGWKVYAGTSNLHQLPEA--ASISQII 373
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYgGGRHFCGGSLISPRWVLTAAHCV---RGSDPSNIRVRLGSHDLSSGEEGqvIKVSKVI 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   374 INGNYTDEQDDYDIALVRLSKPLTLSAHIHPACLPLHGQTFGLNETCWITGFGKTKETDEKTSPFLREVQVNLIDFKKCN 453
Cdd:smart00020  78 IHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSNYNVPAGTTCTVSGWGRTSEGAGSLPDTLQEVNVPIVSNATCR 157

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189011652   454 DYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCeQNNRWYLAGVTSWGTGCGQKNKPGVYTKVTEVLPWI 526
Cdd:smart00020 158 RAYSGGGAITDNMLCAGGLEGGKDACQGDSGGPLVC-NDGRWVLVGIVSWGSGCARPGKPGVYTRVSSYLDWI 229
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 298-526 4.93e-97

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 293.80  E-value: 4.93e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652 298 IVGGALTSESKWPWQVSLHFGT-THICGGTLIDAQWVLTAAHCFfvtREKILEGWKVYAGTSNLHQLPE---AASISQII 373
Cdd:cd00190    1 IVGGSEAKIGSFPWQVSLQYTGgRHFCGGSLISPRWVLTAAHCV---YSSAPSNYTVRLGSHDLSSNEGggqVIKVKKVI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652 374 INGNYTDEQDDYDIALVRLSKPLTLSAHIHPACLPLHGQTFGLNETCWITGFGKTKETDeKTSPFLREVQVNLIDFKKCN 453
Cdd:cd00190   78 VHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYNLPAGTTCTVSGWGRTSEGG-PLPDVLQEVNVPIVSNAECK 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189011652 454 DYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQKNKPGVYTKVTEVLPWI 526
Cdd:cd00190  157 RAYSYGGTITDNMLCAGGLEGGKDACQGDSGGPLVCNDNGRGVLVGIVSWGSGCARPNYPGVYTRVSSYLDWI 229
Trypsin pfam00089
Trypsin;
298-526 1.03e-69

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 223.09  E-value: 1.03e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652  298 IVGGALTSESKWPWQVSLHFGT-THICGGTLIDAQWVLTAAHCFFVTREkilegWKVYAGTSNLHQLPEA---ASISQII 373
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQLSSgKHFCGGSLISENWVLTAAHCVSGASD-----VKVVLGAHNIVLREGGeqkFDVEKII 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652  374 INGNYTDEQDDYDIALVRLSKPLTLSAHIHPACLPLHGQTFGLNETCWITGFGKTKETDEKTSpfLREVQVNLIDFKKCN 453
Cdd:pfam00089  76 VHPNYNPDTLDNDIALLKLESPVTLGDTVRPICLPDASSDLPVGTTCTVSGWGNTKTLGPSDT--LQEVTVPVVSRETCR 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189011652  454 DYlvYDSYLTPRMMCAGDlrGGRDSCQGDSGGPLVCEQNnrwYLAGVTSWGTGCGQKNKPGVYTKVTEVLPWI 526
Cdd:pfam00089 154 SA--YGGTVTDTMICAGA--GGKDACQGDSGGPLVCSDG---ELIGIVSWGYGCASGNYPGVYTPVSSYLDWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 287-526 2.23e-69

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 223.76  E-value: 2.23e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652 287 AHCGLRAMTGRIVGGALTSESKWPWQVSLHF---GTTHICGGTLIDAQWVLTAAHCFFVTRekiLEGWKVYAGTSNLH-Q 362
Cdd:COG5640   20 AAAPAADAAPAIVGGTPATVGEYPWMVALQSsngPSGQFCGGTLIAPRWVLTAAHCVDGDG---PSDLRVVIGSTDLStS 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652 363 LPEAASISQIIINGNYTDEQDDYDIALVRLSKPLTLSAhihPACLPLHGQTFGLNETCWITGFGKTKETDEKTSPFLREV 442
Cdd:COG5640   97 GGTVVKVARIVVHPDYDPATPGNDIALLKLATPVPGVA---PAPLATSADAAAPGTPATVAGWGRTSEGPGSQSGTLRKA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652 443 QVNLIDFKKCNdylVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQKNKPGVYTKVTEV 522
Cdd:COG5640  174 DVPVVSDATCA---AYGGFDGGTMLCAGYPEGGKDACQGDSGGPLVVKDGGGWVLVGVVSWGGGPCAAGYPGVYTRVSAY 250


                 ....
gi 189011652 523 LPWI 526
Cdd:COG5640  251 RDWI 254
SRCR_2 pfam15494
Scavenger receptor cysteine-rich domain; SRCR_2 is a scavenger receptor cysteine-rich domain ...
 203-293 2.90e-26

Scavenger receptor cysteine-rich domain; SRCR_2 is a scavenger receptor cysteine-rich domain family found largely on vertebrate sequences up-stream of the trypsin-like transmembrane serine protease, Spinesin.


Pssm-ID: 464747  Cd Length: 99  Bit Score: 102.41  E-value: 2.90e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652  203 WDKSLLKVYSGSSGEWLPVCSSSWNDTDSERTCQQLGFDSAYRTTEVAHRDVTSSF-------LLSEYNSTIQESL-TRS 274
Cdd:pfam15494   1 GENFLLQVYSSARPSWLPVCSDDWNPAYGRAACQQLGYLRLTHHKSVNLTDISSNSsqsfmklNSSSLNTDLYEALqPRD 80

                          90
                  ....*....|....*....
gi 189011652  275 ECPSRRYVSLQCAHCGLRA 293
Cdd:pfam15494  81 SCSSGSVVSLRCSECGLRS 99
PHA03378 PHA03378
EBNA-3B; Provisional
 11-122 4.93e-12

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 68.94  E-value: 4.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652  11 PARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPPSRSSSGRSSSARSASTTSSPT 90
Cdd:PHA03378 673 PYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPG 752

                         90       100       110
                 ....*....|....*....|....*....|..
gi 189011652  91 RVylvrAIPVGTVIRASPARSAPATRATRESP 122
Cdd:PHA03378 753 RA----RPPAAAPGRARPPAAAPGAPTPQPPP 780
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 215-288 1.03e-07

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 50.03  E-value: 1.03e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 189011652   215 SGEWLPVCSSSWNDTDSERTCQQLGFDSAYRTTEVAH-RDVTSSFLLSEYNSTIQESlTRSECPSRRYVSLQCAH 288
Cdd:smart00202  19 NGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYfGPGSGPIWLDNVRCSGTEA-SLSDCPHSGWGSHNCSH 92
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 9-69 3.30e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.60  E-value: 3.30e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 189011652    9 ASPARPSPQASPARASPQASPARTPPPQASPARASP-------PQASPARAsPARASPVRASPARAPP 69
Cdd:pfam03154 192 TQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhtliqqtPTLHPQRL-PSPHPPLQPMTQPPPP 258
COG5373 COG5373
Uncharacterized membrane protein [Function unknown];
9-69 3.40e-03

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 444140 [Multi-domain]  Cd Length: 854  Bit Score: 40.37  E-value: 3.40e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189011652   9 ASPARPSPQASPARASPQASPARTPPPqaSPARASPPQASPARASPARASPVRASPARAPP 69
Cdd:COG5373   43 AASAPAEPEPEAAAAATAAAPEAAPAP--VPEAPAAPPAAAEAPAPAAAAPPAEAEPAAAP 101
KREPA2 cd23959
Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of ...
 8-69 5.03e-03

Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of the parasitic protozoan's KREPA RNA editing catalytic complex (RECC). Kinetoplastid RNA editing (KRE) proteins occur as pairs or sets of related proteins in multiple complexes. KREPA complex is composed of six components (KREPA1-6), which share a conserved C-terminal region containing an oligonucleotide-binding (OB)-fold-like domain. KREPAs are responsible for the site-specific insertion and deletion of U nucleotides in the kinetoplastid mitochondria pre-messenger RNA. Apart from the conserved C-terminal OB-fold domain, KREPA1, KREPA2, and KREPA3 contain two conserved C2H2 zinc-finger domains. KREPA2 and kinetoplastid RNA editing ligase 1 (KREL1) are specific for ligation post-U-deletion and are paralogous to KREL2 and KREPA1 that are specific for ligation post-U-insertion. KREPA2, is critical for RECC stability and KREL1 integration into the complex.


Pssm-ID: 467780 [Multi-domain]  Cd Length: 424  Bit Score: 39.47  E-value: 5.03e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189011652   8 NASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPvraSPARAPP 69
Cdd:cd23959  168 AAAAAQQSSASPGEVASPFASGTVSASPFATATDTAPSSGAPDGFPAEASAP---SPFAAPA 226
 
Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 297-526 2.99e-99

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 299.59  E-value: 2.99e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   297 RIVGGALTSESKWPWQVSLHF-GTTHICGGTLIDAQWVLTAAHCFfvtREKILEGWKVYAGTSNLHQLPEA--ASISQII 373
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYgGGRHFCGGSLISPRWVLTAAHCV---RGSDPSNIRVRLGSHDLSSGEEGqvIKVSKVI 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   374 INGNYTDEQDDYDIALVRLSKPLTLSAHIHPACLPLHGQTFGLNETCWITGFGKTKETDEKTSPFLREVQVNLIDFKKCN 453
Cdd:smart00020  78 IHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSNYNVPAGTTCTVSGWGRTSEGAGSLPDTLQEVNVPIVSNATCR 157

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189011652   454 DYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCeQNNRWYLAGVTSWGTGCGQKNKPGVYTKVTEVLPWI 526
Cdd:smart00020 158 RAYSGGGAITDNMLCAGGLEGGKDACQGDSGGPLVC-NDGRWVLVGIVSWGSGCARPGKPGVYTRVSSYLDWI 229
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 298-526 4.93e-97

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 293.80  E-value: 4.93e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652 298 IVGGALTSESKWPWQVSLHFGT-THICGGTLIDAQWVLTAAHCFfvtREKILEGWKVYAGTSNLHQLPE---AASISQII 373
Cdd:cd00190    1 IVGGSEAKIGSFPWQVSLQYTGgRHFCGGSLISPRWVLTAAHCV---YSSAPSNYTVRLGSHDLSSNEGggqVIKVKKVI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652 374 INGNYTDEQDDYDIALVRLSKPLTLSAHIHPACLPLHGQTFGLNETCWITGFGKTKETDeKTSPFLREVQVNLIDFKKCN 453
Cdd:cd00190   78 VHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYNLPAGTTCTVSGWGRTSEGG-PLPDVLQEVNVPIVSNAECK 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189011652 454 DYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQKNKPGVYTKVTEVLPWI 526
Cdd:cd00190  157 RAYSYGGTITDNMLCAGGLEGGKDACQGDSGGPLVCNDNGRGVLVGIVSWGSGCARPNYPGVYTRVSSYLDWI 229
Trypsin pfam00089
Trypsin;
298-526 1.03e-69

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 223.09  E-value: 1.03e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652  298 IVGGALTSESKWPWQVSLHFGT-THICGGTLIDAQWVLTAAHCFFVTREkilegWKVYAGTSNLHQLPEA---ASISQII 373
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQLSSgKHFCGGSLISENWVLTAAHCVSGASD-----VKVVLGAHNIVLREGGeqkFDVEKII 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652  374 INGNYTDEQDDYDIALVRLSKPLTLSAHIHPACLPLHGQTFGLNETCWITGFGKTKETDEKTSpfLREVQVNLIDFKKCN 453
Cdd:pfam00089  76 VHPNYNPDTLDNDIALLKLESPVTLGDTVRPICLPDASSDLPVGTTCTVSGWGNTKTLGPSDT--LQEVTVPVVSRETCR 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189011652  454 DYlvYDSYLTPRMMCAGDlrGGRDSCQGDSGGPLVCEQNnrwYLAGVTSWGTGCGQKNKPGVYTKVTEVLPWI 526
Cdd:pfam00089 154 SA--YGGTVTDTMICAGA--GGKDACQGDSGGPLVCSDG---ELIGIVSWGYGCASGNYPGVYTPVSSYLDWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 287-526 2.23e-69

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 223.76  E-value: 2.23e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652 287 AHCGLRAMTGRIVGGALTSESKWPWQVSLHF---GTTHICGGTLIDAQWVLTAAHCFFVTRekiLEGWKVYAGTSNLH-Q 362
Cdd:COG5640   20 AAAPAADAAPAIVGGTPATVGEYPWMVALQSsngPSGQFCGGTLIAPRWVLTAAHCVDGDG---PSDLRVVIGSTDLStS 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652 363 LPEAASISQIIINGNYTDEQDDYDIALVRLSKPLTLSAhihPACLPLHGQTFGLNETCWITGFGKTKETDEKTSPFLREV 442
Cdd:COG5640   97 GGTVVKVARIVVHPDYDPATPGNDIALLKLATPVPGVA---PAPLATSADAAAPGTPATVAGWGRTSEGPGSQSGTLRKA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652 443 QVNLIDFKKCNdylVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQKNKPGVYTKVTEV 522
Cdd:COG5640  174 DVPVVSDATCA---AYGGFDGGTMLCAGYPEGGKDACQGDSGGPLVVKDGGGWVLVGVVSWGGGPCAAGYPGVYTRVSAY 250


                 ....
gi 189011652 523 LPWI 526
Cdd:COG5640  251 RDWI 254
SRCR_2 pfam15494
Scavenger receptor cysteine-rich domain; SRCR_2 is a scavenger receptor cysteine-rich domain ...
 203-293 2.90e-26

Scavenger receptor cysteine-rich domain; SRCR_2 is a scavenger receptor cysteine-rich domain family found largely on vertebrate sequences up-stream of the trypsin-like transmembrane serine protease, Spinesin.


Pssm-ID: 464747  Cd Length: 99  Bit Score: 102.41  E-value: 2.90e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652  203 WDKSLLKVYSGSSGEWLPVCSSSWNDTDSERTCQQLGFDSAYRTTEVAHRDVTSSF-------LLSEYNSTIQESL-TRS 274
Cdd:pfam15494   1 GENFLLQVYSSARPSWLPVCSDDWNPAYGRAACQQLGYLRLTHHKSVNLTDISSNSsqsfmklNSSSLNTDLYEALqPRD 80

                          90
                  ....*....|....*....
gi 189011652  275 ECPSRRYVSLQCAHCGLRA 293
Cdd:pfam15494  81 SCSSGSVVSLRCSECGLRS 99
eMpr COG3591
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, ...
 318-506 1.42e-14

V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442810 [Multi-domain]  Cd Length: 194  Bit Score: 72.40  E-value: 1.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652 318 GTTHICGGTLIDAQWVLTAAHCFF-VTREKILEGWKVYAGTSNLHqlPEAASISQIIINGNYTDEQD-DYDIALVRLSKP 395
Cdd:COG3591    9 GGGGVCTGTLIGPNLVLTAGHCVYdGAGGGWATNIVFVPGYNGGP--YGTATATRFRVPPGWVASGDaGYDYALLRLDEP 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652 396 LTLSAhihpACLPLHGQTFGL-NETCWITGFGKtketDEKTSPFLRevqvnlidfkkCNDYLVYDSyltprmmcAGDLRG 474
Cdd:COG3591   87 LGDTT----GWLGLAFNDAPLaGEPVTIIGYPG----DRPKDLSLD-----------CSGRVTGVQ--------GNRLSY 139

                        170       180       190
                 ....*....|....*....|....*....|..
gi 189011652 475 GRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTG 506
Cdd:COG3591  140 DCDTTGGSSGSPVLDDSDGGGRVVGVHSAGGA 171
PHA03378 PHA03378
EBNA-3B; Provisional
 11-122 4.93e-12

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 68.94  E-value: 4.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652  11 PARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPPSRSSSGRSSSARSASTTSSPT 90
Cdd:PHA03378 673 PYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPG 752

                         90       100       110
                 ....*....|....*....|....*....|..
gi 189011652  91 RVylvrAIPVGTVIRASPARSAPATRATRESP 122
Cdd:PHA03378 753 RA----RPPAAAPGRARPPAAAPGAPTPQPPP 780
PHA03378 PHA03378
EBNA-3B; Provisional
 8-122 1.23e-11

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 67.40  E-value: 1.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   8 NASPARPS----PQASPARA-SPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPPSRSSSGRSSSARS 82
Cdd:PHA03378 675 QPSPTGANtmlpIQWAPGTMqPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRA 754

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 189011652  83 ASTTSSPTRVylvrAIPVGTVIRASPARSAPATRATRESP 122
Cdd:PHA03378 755 RPPAAAPGRA----RPPAAAPGAPTPQPPPQAPPAPQQRP 790
PHA03378 PHA03378
EBNA-3B; Provisional
 7-69 1.50e-10

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 63.93  E-value: 1.50e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 189011652   7 RNASPARPsPQASPARAS-PQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPP 69
Cdd:PHA03378 699 RAPTPMRP-PAAPPGRAQrPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAP 761
PHA03378 PHA03378
EBNA-3B; Provisional
 7-127 2.86e-10

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 63.16  E-value: 2.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   7 RNASPARPSPQASPARAS-PQASPARTPPPQASPARASPPQASPARASPARASPVRASPA---RAPPSRSSSGRSSSARS 82
Cdd:PHA03378 718 AAATGRARPPAAAPGRARpPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQpppQAPPAPQQRPRGAPTPQ 797

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 189011652  83 ASTTSSPTRVYLV-RAIPVGTVIRASPARSAPATRATRESPGLSFP 127
Cdd:PHA03378 798 PPPQAGPTSMQLMpRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKP 843
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 3-138 3.52e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 59.34  E-value: 3.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   3 RGSHRNASPARPSPQASPARASPQASP-ARTPPPQAS----PARASPPQASPARASPARASPVRASPARAPPSRSSSGRS 77
Cdd:PRK14951 367 AAAAEAAAPAEKKTPARPEAAAPAAAPvAQAAAAPAPaaapAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVA 446

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189011652  78 SSARSASTTSSPTRVYLVRAIPvGTVIRASPARSAPATRATRESPGLSFPkfSWQETQRQL 138
Cdd:PRK14951 447 LAPAPPAQAAPETVAIPVRVAP-EPAVASAAPAPAAAPAAARLTPTEEGD--VWHATVQQL 504
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
9-142 9.83e-09

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 57.96  E-value: 9.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   9 ASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASP------ARASPVRASPARAPPSRSSSGRSSSARS 82
Cdd:PRK12323 453 APAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPweelppEFASPAPAQPDAAPAGWVAESIPDPATA 532

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189011652  83 ASTTSSPTRVYLVRAIPVGTViRASPARSAPATRATRESPGLSfPKF--SWQETQRQLPLIG 142
Cdd:PRK12323 533 DPDDAFETLAPAPAAAPAPRA-AAATEPVVAPRPPRASASGLP-DMFdgDWPALAARLPVRG 592
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
4-142 4.27e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 56.04  E-value: 4.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   4 GSHRNASPAR----PSPQASPARASPQASPARTPPPQASPARASPPQAS--PARASPARASPVRASPARAPPSRSSSGRS 77
Cdd:PRK12323 367 QSGGGAGPATaaaaPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAarAVAAAPARRSPAPEALAAARQASARGPGG 446

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 189011652  78 SSARSASTTSSP---TRVYLVRAIPVGTVIRASPARSAPAtRATRESPGLSFPkfsWQETQRQLPLIG 142
Cdd:PRK12323 447 APAPAPAPAAAPaaaARPAAAGPRPVAAAAAAAPARAAPA-AAPAPADDDPPP---WEELPPEFASPA 510
PHA03378 PHA03378
EBNA-3B; Provisional
 10-122 7.39e-08

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 55.46  E-value: 7.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652  10 SPARPsPQASPARAS-PQASPARTPPPQASPARASP---PQASPARASPARASPVRASPARAPPsrssSGRSSSARSAST 85
Cdd:PHA03378 742 GRARP-PAAAPGRARpPAAAPGRARPPAAAPGAPTPqppPQAPPAPQQRPRGAPTPQPPPQAGP----TSMQLMPRAAPG 816

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 189011652  86 TSSPTRvYLVRAIPVGTVIRASPARSAPAtRATRESP 122
Cdd:PHA03378 817 QQGPTK-QILRQLLTGGVKRGRPSLKKPA-ALERQAA 851
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 215-288 1.03e-07

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 50.03  E-value: 1.03e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 189011652   215 SGEWLPVCSSSWNDTDSERTCQQLGFDSAYRTTEVAH-RDVTSSFLLSEYNSTIQESlTRSECPSRRYVSLQCAH 288
Cdd:smart00202  19 NGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYfGPGSGPIWLDNVRCSGTEA-SLSDCPHSGWGSHNCSH 92
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 7-123 1.81e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 54.22  E-value: 1.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   7 RNASPARPSPQASPARASP-QASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPPSRSSSGRSSSARSAST 85
Cdd:PRK07764 383 RRLGVAGGAGAPAAAAPSAaAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAP 462

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 189011652  86 TSSPTrvylvraiPVGTVIRASPARSAPATRATRESPG 123
Cdd:PRK07764 463 SAQPA--------PAPAAAPEPTAAPAPAPPAAPAPAA 492
PHA03247 PHA03247
large tegument protein UL36; Provisional
 4-139 2.05e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 2.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652    4 GSHRNASPARPSPQASPA--RASPQASPARTPPPQASPARASPPQ-------ASPARASPARASPVRASPARAPPSRSSS 74
Cdd:PHA03247 2753 GPARPARPPTTAGPPAPAppAAPAAGPPRRLTRPAVASLSESRESlpspwdpADPPAAVLAPAAALPPAASPAGPLPPPT 2832

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 189011652   75 GRSSSARSASTTSSPTRVYLVRAI-PVGTVIRASPARSAPATRATRESP---GLSFPKFSWQETQRQLP 139
Cdd:PHA03247 2833 SAQPTAPPPPPGPPPPSLPLGGSVaPGGDVRRRPPSRSPAAKPAAPARPpvrRLARPAVSRSTESFALP 2901
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 9-118 2.00e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 50.75  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   9 ASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPPSRSSSGRSSSARSASTTSS 88
Cdd:PRK07764 413 AAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAA 492

                         90       100       110
                 ....*....|....*....|....*....|
gi 189011652  89 PTRVYLVRAIPVGTVIRASPARSAPATRAT 118
Cdd:PRK07764 493 APAAPAAPAAPAGADDAATLRERWPEILAA 522
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 16-125 2.35e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 50.48  E-value: 2.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652  16 PQASPARASPQASPARTPPPQASPARASPPQASPARAsPARASPVRASPARAPPSRSSSGRSSSARSASTTSSPTRVYLV 95
Cdd:PRK14951 366 PAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPA-PAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAA 444

                         90       100       110
                 ....*....|....*....|....*....|
gi 189011652  96 RAIPVGTVIRASPARSAPATRATRESPGLS 125
Cdd:PRK14951 445 VALAPAPPAQAAPETVAIPVRVAPEPAVAS 474
PHA03247 PHA03247
large tegument protein UL36; Provisional
 3-122 2.89e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 2.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652    3 RGSHRNASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPArappsrsssgrsssars 82
Cdd:PHA03247 2672 RAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPA----------------- 2734

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 189011652   83 asttssPTRVYLVRAIPVGTVIRASPARSA-PATRATRESP 122
Cdd:PHA03247 2735 ------LPAAPAPPAVPAGPATPGGPARPArPPTTAGPPAP 2769
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
3-127 3.39e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 49.85  E-value: 3.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   3 RGSHRNASPARPSPQASPARASPQASPARTPPPQ-ASPARASPPQASPARASPARASPVRASPARAP---PSRSSSGRSS 78
Cdd:PRK07003 380 VPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKaAAAAAATRAEAPPAAPAPPATADRGDDAADGDapvPAKANARASA 459

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 189011652  79 SARSASTTSSPTRVYLVRAIPVGTVirASPARSAPATRATRESPGLSFP 127
Cdd:PRK07003 460 DSRCDERDAQPPADSGSASAPASDA--PPDAAFEPAPRAAAPSAATPAA 506
PHA03247 PHA03247
large tegument protein UL36; Provisional
 5-122 4.47e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 4.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652    5 SHRNASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPAR---ASPARASPVRASPARAPPSRSSSGRSSSAR 81
Cdd:PHA03247 2727 AARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAapaAGPPRRLTRPAVASLSESRESLPSPWDPAD 2806

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 189011652   82 SASTTSSPTRVYLVRAIPVGTVirASPARSAPATRATRESP 122
Cdd:PHA03247 2807 PPAAVLAPAAALPPAASPAGPL--PPPTSAQPTAPPPPPGP 2845
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
9-127 6.35e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 49.08  E-value: 6.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   9 ASPARPSP-QASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPPSRSSSGRSSSARSASTTS 87
Cdd:PRK07003 425 APPAAPAPpATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATP 504

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 189011652  88 SPTRVYLVRAipVGTVIRASPARSAPATRATRESPGLSFP 127
Cdd:PRK07003 505 AAVPDARAPA--AASREDAPAAAAPPAPEARPPTPAAAAP 542
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2-127 1.22e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652    2 DRGSHRNASPARPSPqasparasPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPPSRSSSGRSSSAR 81
Cdd:PHA03247 2604 DRGDPRGPAPPSPLP--------PDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ 2675

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 189011652   82 SASTTSSPTRVYLVRAI-PVGTVIRASPARSAPATRATRESPGLSFP 127
Cdd:PHA03247 2676 ASSPPQRPRRRAARPTVgSLTSLADPPPPPPTPEPAPHALVSATPLP 2722
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 9-69 1.24e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 48.35  E-value: 1.24e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189011652    9 ASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPP 69
Cdd:PRK12270   54 AASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVE 114
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 4-120 1.35e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.06  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   4 GSHRNASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPArASPARASPVRASPARAPPSRSSSGRSSSARSA 83
Cdd:PRK07764 668 GWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQA-DDPAAQPPQAAQGASAPSPAADDPVPLPPEPD 746

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 189011652  84 STTSSPTRVYLVRAIPVGTVIRASPARSAPATRATRE 120
Cdd:PRK07764 747 DPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEE 783
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 2-69 1.70e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 47.40  E-value: 1.70e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 189011652   2 DRGSHRNASPARPSPQASPARASPQASPAR-----TPPPQASPARASPPQASPARASP-ARASPVRASPARAPP 69
Cdd:PRK14951 400 APAPAAAPAAAASAPAAPPAAAPPAPVAAPaaaapAAAPAAAPAAVALAPAPPAQAAPeTVAIPVRVAPEPAVA 473
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 9-69 1.78e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.67  E-value: 1.78e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189011652   9 ASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPP 69
Cdd:PRK07764 661 DASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQP 721
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
9-124 2.76e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 47.15  E-value: 2.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   9 ASPARPSPQASPARASPQASPArtppPQASPARASPPQASPARASPARASPVRASPARAPPSRSSSGRSSSARSASTTSS 88
Cdd:PRK07003 454 NARASADSRCDERDAQPPADSG----SASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPA 529

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 189011652  89 PtrvylvRAIPvgtvirASPARSAPATRATRESPGL 124
Cdd:PRK07003 530 P------EARP------PTPAAAAPAARAGGAAAAL 553
flhF PRK06995
flagellar biosynthesis protein FlhF;
5-139 3.15e-05

flagellar biosynthesis protein FlhF;


Pssm-ID: 235904 [Multi-domain]  Cd Length: 484  Bit Score: 46.50  E-value: 3.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   5 SHRNASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPPSRSSSGRSSSARSAS 84
Cdd:PRK06995  46 SDLAALAPPAAAAPAAAQPPPAAAPAAVSRPAAPAAEPAPWLVEHAKRLTAQREQLVARAAAPAAPEAQAPAAPAERAAA 125

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 189011652  85 TTSSPTRVYLVRAIP---VGTVIRASPARSAPAT----------------RATRESpglSFPKFSWQETQRQLP 139
Cdd:PRK06995 126 ENAARRLARAAAAAPrprVPADAAAAVADAVKARierivndtvmqelrslRGMLEE---QLASLAWGERQRRDP 196
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1-69 3.81e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 3.81e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 189011652    1 MDRGSHRNASPARPSPQASPARASPQASPARTPPPQASPArASPPQASPARASPARASPVRASPARAPP 69
Cdd:PHA03307  137 MLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPL-SSPEETARAPSSPPAEPPPSTPPAAASP 204
PHA03247 PHA03247
large tegument protein UL36; Provisional
 9-115 4.60e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 4.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652    9 ASPARPSPQASPARA-SPQASPARTPPPQ--ASPARASPPQASPARASPARASPVRASPARAPPSRSSSGRSSSARSAST 85
Cdd:PHA03247 2718 ATPLPPGPAAARQASpALPAAPAPPAVPAgpATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                          90       100       110
                  ....*....|....*....|....*....|
gi 189011652   86 TSSPTRVYLVRAiPVGTVIRASPARSAPAT 115
Cdd:PHA03247 2798 LPSPWDPADPPA-AVLAPAAALPPAASPAG 2826
PHA03247 PHA03247
large tegument protein UL36; Provisional
 7-123 8.35e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 8.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652    7 RNASPARPSPQAS-PA--------RASPQASPARTP-PPQASPARASPPQASPARASPARASPVRASPARAPPSRSSSGR 76
Cdd:PHA03247 2566 RSVPPPRPAPRPSePAvtsrarrpDAPPQSARPRAPvDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPT 2645

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 189011652   77 SSSARSASTTSSPTRVYLV-RAIPVGTVIRASPARSAPATRATRESPG 123
Cdd:PHA03247 2646 VPPPERPRDDPAPGRVSRPrRARRLGRAAQASSPPQRPRRRAARPTVG 2693
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 3-69 8.51e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 45.12  E-value: 8.51e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 189011652   3 RGSHRNASPARPSPqASPARASPQASPARTPPPQASPARASPPQASPArasPARASPVRASPARAPP 69
Cdd:PRK14965 386 SAAWGAPTPAAPAA-PPPAAAPPVPPAAPARPAAARPAPAPAPPAAAA---PPARSADPAAAASAGD 448
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 9-69 8.53e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 45.19  E-value: 8.53e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189011652   9 ASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPArASPArASPVRASPARAPP 69
Cdd:PRK14950 372 TAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVP-PRPV-APPVPHTPESAPK 430
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
9-121 9.19e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 45.23  E-value: 9.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   9 ASPARPSPQASPARASPQASPARTPPPQASPARASP-PQASPARASPARASPVRASPARAPPSRSSSGRSSSARSASTTS 87
Cdd:PRK07003 407 GAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAaDGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPP 486

                         90       100       110
                 ....*....|....*....|....*....|....
gi 189011652  88 SPTRVYLVRAIPVGTVIRASPARSAPATRATRES 121
Cdd:PRK07003 487 DAAFEPAPRAAAPSAATPAAVPDARAPAAASRED 520
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
9-127 1.02e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 45.23  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   9 ASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPPsRSSSGRSSSARSASTTSS 88
Cdd:PRK07003 367 APGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPP-AAPAPPATADRGDDAADG 445

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 189011652  89 PTRVYLVRAIPVGTVIRASPARSAPAT-RATRESPGLSFP 127
Cdd:PRK07003 446 DAPVPAKANARASADSRCDERDAQPPAdSGSASAPASDAP 485
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 4-66 1.05e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.16  E-value: 1.05e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 189011652    4 GSHRNASPARPSPQASPARASPQASPARTPPPQASPARASP--PQASPARASPARASPVRASPAR 66
Cdd:PHA03307  335 SSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPssPAASAGRPTRRRARAAVAGRAR 399
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 216-288 1.58e-04

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 40.82  E-value: 1.58e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 189011652  216 GEWLPVCSSSWNDTDSERTCQQLGFDSA---YRTTEVAHRDVTSSFLLSEYNSTIQE-SLtrSECPSRRYVSLQCAH 288
Cdd:pfam00530  15 GSWGTVCDDGWDLRDAHVVCRQLGCGGAvsaPSGCSYFGPGSTGPIWLDDVRCSGNEtSL--WQCPHRPWGNHNCSH 89
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 8-69 2.20e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 44.03  E-value: 2.20e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189011652   8 NASPARPSPQASPARASPQASPArTPPPQASPARASPPQASParaSPARASPVRASPARAPP 69
Cdd:PRK14950 390 KAAAAANIPPKEPVRETATPPPV-PPRPVAPPVPHTPESAPK---LTRAAIPVDEKPKYTPP 447
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 10-69 2.37e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 44.09  E-value: 2.37e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652  10 SPARPSPQASPARASPQASPARTPPPQASPArasPPQASPARASPARASPVRASPARAPP 69
Cdd:PRK07994 362 AAPLPEPEVPPQSAAPAASAQATAAPTAAVA---PPQAPAVPPPPASAPQQAPAVPLPET 418
PHA03247 PHA03247
large tegument protein UL36; Provisional
 3-127 3.00e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 3.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652    3 RGSHRNASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPAR--APPSRSSSGRSSSA 80
Cdd:PHA03247 2865 RPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQpqPPPPPPPRPQPPLA 2944

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 189011652   81 RSASTTSSPTRVYLVRAIPVGTVIR---ASPARSAPATRATRESPGLSFP 127
Cdd:PHA03247 2945 PTTDPAGAGEPSGAVPQPWLGALVPgrvAVPRFRVPQPAPSREAPASSTP 2994
PHA03377 PHA03377
EBNA-3C; Provisional
 5-137 3.20e-04

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 43.50  E-value: 3.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652    5 SHRNASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPPSRSSSGRSSSARSAS 84
Cdd:PHA03377  543 SGRRQKRATPPKVSPSDRGPPKASPPVMAPPSTGPRVMATPSTGPRDMAPPSTGPRQQAKCKDGPPASGPHEKQPPSSAP 622

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 189011652   85 TTSSPTRVYLV---RAIPVGTvirASPARSAPATRATRESPGLSFPKFSWQETQRQ 137
Cdd:PHA03377  623 RDMAPSVVRMFlreRLLEQST---GPKPKSFWEMRAGRDGSGIQQEPSSRRQPATQ 675
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
9-69 3.27e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 43.61  E-value: 3.27e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189011652   9 ASPARPSPQASPARASPQASPARTP--PPQASPARASPPQASPARASPARASPVRASPARAPP 69
Cdd:PRK14971 387 AAAPQPSAAAAASPSPSQSSAAAQPsaPQSATQPAGTPPTVSVDPPAAVPVNPPSTAPQAVRP 449
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 9-69 3.30e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.60  E-value: 3.30e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 189011652    9 ASPARPSPQASPARASPQASPARTPPPQASPARASP-------PQASPARAsPARASPVRASPARAPP 69
Cdd:pfam03154 192 TQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhtliqqtPTLHPQRL-PSPHPPLQPMTQPPPP 258
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 9-139 3.31e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 43.26  E-value: 3.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   9 ASPARPSPQASPARASPQASPARTPPPQASPARASPPQasPARASPARASPVRASPARAPPSRSSSGRSSSARSasttss 88
Cdd:PRK14950 363 VPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPK--EPVRETATPPPVPPRPVAPPVPHTPESAPKLTRA------ 434

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 189011652  89 ptrvylvrAIPVGTVIRASPARSAPATRATRESPG--LSFPKFSWQETQRQLP 139
Cdd:PRK14950 435 --------AIPVDEKPKYTPPAPPKEEEKALIADGdvLEQLEAIWKQILRDVP 479
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 7-68 5.94e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 42.42  E-value: 5.94e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189011652   7 RNASPARPSPQASPARASPQASPARTPPPQAsPARASPPQASPARASPARASPVRASPARAP 68
Cdd:PRK14965 380 GAPAPPSAAWGAPTPAAPAAPPPAAAPPVPP-AAPARPAAARPAPAPAPPAAAAPPARSADP 440
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 9-69 6.24e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.85  E-value: 6.24e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189011652    9 ASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPP 69
Cdd:PHA03307  327 SSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTR 387
PHA03378 PHA03378
EBNA-3B; Provisional
 11-127 6.66e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.75  E-value: 6.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652  11 PARPSPQASPARASPQASPARTPPPQ--ASPARASPPQASPARASPARASPVRASPARAPPSRSSSGRSSSARSASTTSS 88
Cdd:PHA03378 646 LVFPTPHQPPQVEITPYKPTWTQIGHipYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRAR 725

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 189011652  89 PTRVYLVRA-IPVGTVIRASPARSAP-ATRATRESPGLSFP 127
Cdd:PHA03378 726 PPAAAPGRArPPAAAPGRARPPAAAPgRARPPAAAPGRARP 766
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 1-65 6.66e-04

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 41.80  E-value: 6.66e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 189011652   1 MDRGSHRNASP-ARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASpvRASPA 65
Cdd:PHA03201   1 MKRARSRSPSPpRRPSPPRPTPPRSPDASPEETPPSPPGPGAEPPPGRAAGPAAPRRRP--RGCPA 64
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 2-123 6.79e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 6.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   2 DRGSHRNASPARPSPQASP---ARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPPSRSSSGRSS 78
Cdd:PRK07764 591 APGAAGGEGPPAPASSGPPeeaARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWP 670

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 189011652  79 SARSASTTSSPTrvylVRAIPVGTVIRASPARSAPATRATRESPG 123
Cdd:PRK07764 671 AKAGGAAPAAPP----PAPAPAAPAAPAGAAPAQPAPAPAATPPA 711
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 5-69 7.19e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 42.36  E-value: 7.19e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 189011652   5 SHRNASPARPSPQASPARASPQASPARTPPPQASPARASP--PQASPARASPARAspvrASPARAPP 69
Cdd:PRK14959 415 TPSSAAPATPAPSAAPSPRVPWDDAPPAPPRSGIPPRPAPrmPEASPVPGAPDSV----ASASDAPP 477
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 9-127 8.13e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 8.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652    9 ASPARPSPQASPARASPQA------SPARTPPPQASPARASPPqaSPARASPARASPVRASPA-------RAPPSRSSSG 75
Cdd:PHA03307  163 ASDAASSRQAALPLSSPEEtarapsSPPAEPPPSTPPAAASPR--PPRRSSPISASASSPAPApgrsaadDAGASSSDSS 240

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 189011652   76 RSSSARSASTTSSPTRVYLVRAIPVGTVIRASPARSAPATRATRESPGLSFP 127
Cdd:PHA03307  241 SSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPR 292
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
11-69 8.45e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 42.07  E-value: 8.45e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 189011652  11 PARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPP 69
Cdd:PRK14971 386 PAAAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNPPSTAP 444
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 9-118 8.80e-04

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 41.86  E-value: 8.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   9 ASPARPSpqASPARASPQASPARTPPPQAS--PARASPPQASPArASPARASPVRASPARAPPSRSSSGRSSSARSASTT 86
Cdd:PTZ00436 241 AAPAKAA--AAPAKAAAPPAKAAAPPAKAAapPAKAAAPPAKAA-APPAKAAAPPAKAAAAPAKAAAAPAKAAAAPAKAA 317

                         90       100       110
                 ....*....|....*....|....*....|..
gi 189011652  87 SSPTRvylVRAIPVGTVIRASPARSAPATRAT 118
Cdd:PTZ00436 318 APPAK---AAAPPAKAATPPAKAAAPPAKAAA 346
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 12-69 9.22e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 42.04  E-value: 9.22e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 189011652  12 ARPSPQASPARASPQASPARTPPPQASPARASPP-QASPARASPARASPvrASPARAPP 69
Cdd:PRK14965 378 ERGAPAPPSAAWGAPTPAAPAAPPPAAAPPVPPAaPARPAAARPAPAPA--PPAAAAPP 434
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 15-69 1.02e-03

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 41.82  E-value: 1.02e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 189011652  15 SPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPP 69
Cdd:PRK01297  12 GEAEQPAPAPPSPAAAPAPPPPAKTAAPATKAAAPAAAAPRAEKPKKDKPRRERK 66
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 15-69 1.02e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 40.98  E-value: 1.02e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 189011652  15 SPQASPARASPQASPARTPPPQASPARASPPQASPARA-SPARASPVRASPARAPP 69
Cdd:PLN02983 144 PPPPAPVVMMQPPPPHAMPPASPPAAQPAPSAPASSPPpTPASPPPAKAPKSSHPP 199
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 3-69 1.08e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 1.08e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189011652   3 RGSHRNASPARPSPQASP--ARASPQASPARTPP----PQASPARASPPQASPARASPARASPVRASPARAPP 69
Cdd:PRK07764 424 APAAAPQPAPAPAPAPAPpsPAGNAPAGGAPSPPpaaaPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAA 496
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 11-69 1.34e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 41.47  E-value: 1.34e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 189011652  11 PARPSPQASPARASPQAsPARTPPPQASPARASPPQASPARASPArasPVRASPARAPP 69
Cdd:PRK14954 397 PDLPQPDRHPGPAKPEA-PGARPAELPSPASAPTPEQQPPVARSA---PLPPSPQASAP 451
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 8-69 1.36e-03

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 41.06  E-value: 1.36e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 189011652    8 NASPArPSPQASPARASPQASPARTPPPQA-----SPARASPPQASPARASPARASPVRASPARAPP 69
Cdd:pfam07174  38 HADPE-PAPPPPSTATAPPAPPPPPPAPAApapppPPAAPNAPNAPPPPADPNAPPPPPADPNAPPP 103
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 9-66 1.40e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 41.39  E-value: 1.40e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   9 ASPARPSPQASPARASPQASPARTPPPQASPARASPPQ--ASPARASPARASPVRASPAR 66
Cdd:PRK07994 391 VAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQlqRAQGATKAKKSEPAAASRAR 450
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 10-69 1.79e-03

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 40.61  E-value: 1.79e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189011652  10 SPARPSPQ-ASPARASPQASPARTPPpqaSPARASPPQASPArASPARASPVRASPARAPP 69
Cdd:PHA02682  85 SPACAAPApACPACAPAAPAPAVTCP---APAPACPPATAPT-CPPPAVCPAPARPAPACP 141
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 12-69 2.02e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.03  E-value: 2.02e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 189011652   12 ARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPP 69
Cdd:PRK12270   34 ADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAA 91
PRK12373 PRK12373
NADH-quinone oxidoreductase subunit E;
7-68 2.06e-03

NADH-quinone oxidoreductase subunit E;


Pssm-ID: 237082 [Multi-domain]  Cd Length: 400  Bit Score: 40.56  E-value: 2.06e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 189011652   7 RNASPARPSPQASPARASPQASPA-----RTPPPQASPARASPPQASPARASPARASPVRASPARAP 68
Cdd:PRK12373 236 GDAAPVPPSEAARPKSADAETNAAlktpaTAPKAAAKNAKAPEAQPVSGTAAAEPAPKEAAKAAAAA 302
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 23-69 2.10e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 40.21  E-value: 2.10e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 189011652  23 ASPQASPART-----PPPQASPARASPPQASPArASPARASPVrASPARAPP 69
Cdd:PLN02983 140 ALPQPPPPAPvvmmqPPPPHAMPPASPPAAQPA-PSAPASSPP-PTPASPPP 189
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 9-127 2.36e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 2.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   9 ASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASP-VRASPARAPPSRSSSGRSSSARSASTTS 87
Cdd:PRK07764 616 AAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGdGWPAKAGGAAPAAPPPAPAPAAPAAPAG 695

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 189011652  88 SPTRVYLVRAIPVGTVIRASPARSAPATRATRESPGLSFP 127
Cdd:PRK07764 696 AAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAA 735
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 17-137 2.38e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 2.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652  17 QASPARASPQASPARTPPPQASPARASPPQASPARASPARASPvrASPARAPPSRSSSGRSSSARSASTTSSPTRVYLVR 96
Cdd:PRK07764 587 VVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAP--AGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASD 664

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 189011652  97 AIPVGTVIRASPARSAPATRATRESPGLSFPKFSWQETQRQ 137
Cdd:PRK07764 665 GGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP 705
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2-123 2.58e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.92  E-value: 2.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652    2 DRGSHRNASPARPSPQASPARASPQ--------ASPARTPPPQASPARASPPQASPARASPARASP---VRASPARAPPS 70
Cdd:PHA03307  114 PDPPPPTPPPASPPPSPAPDLSEMLrpvgspgpPPAASPPAAGASPAAVASDAASSRQAALPLSSPeetARAPSSPPAEP 193

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 189011652   71 RSSSGRSSSARSASTTSSPTRVYLVRAIPVGTVIRASPARSAPATRATRESPG 123
Cdd:PHA03307  194 PPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSG 246
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
16-122 2.66e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 2.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652  16 PQASPARASPqASPARTPPPQASPARASPPQASPARASPAraspvrASPARAPPSRSSSGRSSSARSASTTSSPTRVYLV 95
Cdd:PRK12323 365 PGQSGGGAGP-ATAAAAPVAQPAPAAAAPAAAAPAPAAPP------AAPAAAPAAAAAARAVAAAPARRSPAPEALAAAR 437

                         90       100
                 ....*....|....*....|....*..
gi 189011652  96 RAIPVGTVIRASPARSAPATRATRESP 122
Cdd:PRK12323 438 QASARGPGGAPAPAPAPAAAPAAAARP 464
PRK06975 PRK06975
bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed
 9-65 3.05e-03

bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed


Pssm-ID: 235899 [Multi-domain]  Cd Length: 656  Bit Score: 40.47  E-value: 3.05e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 189011652   9 ASPARPSPqASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPA 65
Cdd:PRK06975 270 AQPATAAP-APSRMTDTNDSKSVTSQPAAAAAAPAPPPNPPATPPEPPARRGRGSAA 325
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 10-68 3.16e-03

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 39.84  E-value: 3.16e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189011652  10 SPARPSPQAS---PARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAP 68
Cdd:PHA02682  99 APAAPAPAVTcpaPAPACPPATAPTCPPPAVCPAPARPAPACPPSTRQCPPAPPLPTPKPAP 160
COG5373 COG5373
Uncharacterized membrane protein [Function unknown];
9-69 3.40e-03

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 444140 [Multi-domain]  Cd Length: 854  Bit Score: 40.37  E-value: 3.40e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189011652   9 ASPARPSPQASPARASPQASPARTPPPqaSPARASPPQASPARASPARASPVRASPARAPP 69
Cdd:COG5373   43 AASAPAEPEPEAAAAATAAAPEAAPAP--VPEAPAAPPAAAEAPAPAAAAPPAEAEPAAAP 101
DUF6264 pfam19779
Family of unknown function (DUF6264); This family of putative integral membrane proteins is ...
 13-69 3.65e-03

Family of unknown function (DUF6264); This family of putative integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 179 and 218 amino acids in length.


Pssm-ID: 466182  Cd Length: 182  Bit Score: 38.79  E-value: 3.65e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 189011652   13 RPSPQAsPARASPQASPArTPPPQASPARASPPQASPARASPARASPVRASPARAPP 69
Cdd:pfam19779  14 RAPIGD-PAAAAAAAPPA-APAPAAPAPPAAPAAPPAAPPPPGAPAPGAPAAARRAR 68
QWRF pfam04484
QWRF family; AUG8 belongs to the plant QWRF motif-containing protein family, which also ...
 2-69 3.70e-03

QWRF family; AUG8 belongs to the plant QWRF motif-containing protein family, which also includes microtubule-associated protein ENDOSPERM DEFECTIVE 1 and SNOWY COTYLEDON 3. AUG8 binds the microtubule plus-end and participates in the reorientation of microtubules in hypocotyls (the stem of a germinating seedling).


Pssm-ID: 461327 [Multi-domain]  Cd Length: 304  Bit Score: 39.65  E-value: 3.70e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189011652    2 DRGShRNASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPAR-----ASPARASPvraSPARAPP 69
Cdd:pfam04484  33 DPGS-PTSSSSKVPSKKSRLDGAPSSSPRSRANSRASPGRGSSRALSPSKlgsstSSPSRGLP---SPSRPRS 101
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 9-68 3.73e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 40.23  E-value: 3.73e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   9 ASPARPsPQASPARASPQASPARTPPPQASPARASPPQASPArasPARASPVRASPARAP 68
Cdd:PRK07994 366 PEPEVP-PQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASA---PQQAPAVPLPETTSQ 421
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 10-68 3.75e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 39.44  E-value: 3.75e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652  10 SPARPSPQASPARASPQASPartPPPQASPARASPPQASPARAS-PARASPVRASPARAP 68
Cdd:PLN02983 156 PPPHAMPPASPPAAQPAPSA---PASSPPPTPASPPPAKAPKSShPPLKSPMAGTFYRSP 212
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 5-69 3.92e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 3.92e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 189011652    5 SHRNASPARPSPQASPARASPQASP-ARTPPPQASPARASPPQASPARASPARASPVRASPARAPP 69
Cdd:PHA03307  102 REGSPTPPGPSSPDPPPPTPPPASPpPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAA 167
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 9-68 4.24e-03

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 39.90  E-value: 4.24e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189011652   9 ASPARPSPQASPARASPQASPAR-TPPPQASPARASPPQAS-PARASPARASPVRASPARAP 68
Cdd:PRK01297  14 AEQPAPAPPSPAAAPAPPPPAKTaAPATKAAAPAAAAPRAEkPKKDKPRRERKPKPASLWKL 75
FimV COG3170
Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];
16-63 4.46e-03

Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];


Pssm-ID: 442403 [Multi-domain]  Cd Length: 508  Bit Score: 39.78  E-value: 4.46e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 189011652  16 PQASPARASPQASPARTPP-PQASPARASPPQASPARASPARASPVRAS 63
Cdd:COG3170  107 PAYAAAAAAPAAAPAPAPAaPAAAAAAADQPAAEAAPAASGEYYPVRPG 155
PHA03247 PHA03247
large tegument protein UL36; Provisional
 4-68 4.62e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 4.62e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 189011652    4 GSHRNASPARPSPQASPARASPQAsPARTPPPQASPARASPPQASPARASP-ARASPVRASPARAP 68
Cdd:PHA03247  400 GGDDQTRPAAPVPASVPTPAPTPV-PASAPPPPATPLPSAEPGSDDGPAPPpERQPPAPATEPAPD 464
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 18-69 4.64e-03

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 39.14  E-value: 4.64e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 189011652   18 ASPARASPQASPARTPPPQASPArASPPQASPARASPARASPVRASPARAPP 69
Cdd:pfam07174  32 ALPAVAHADPEPAPPPPSTATAP-PAPPPPPPAPAAPAPPPPPAAPNAPNAP 82
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
5-69 4.77e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 39.76  E-value: 4.77e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 189011652   5 SHRNASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPP 69
Cdd:PRK14971 405 SSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPVSKVSSLGPS 469
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 5-69 4.85e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.77  E-value: 4.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 189011652    5 SHRNASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPP 69
Cdd:PHA03307  311 SPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAP 375
FimV COG3170
Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];
9-69 4.99e-03

Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];


Pssm-ID: 442403 [Multi-domain]  Cd Length: 508  Bit Score: 39.39  E-value: 4.99e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189011652   9 ASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPP 69
Cdd:COG3170  111 AAAAAPAAAPAPAPAAPAAAAAAADQPAAEAAPAASGEYYPVRPGDTLWSIAARPVRPSSG 171
DUF1986 pfam09342
Domain of unknown function (DUF1986); This domain is found in serine proteases and is ...
 309-408 4.99e-03

Domain of unknown function (DUF1986); This domain is found in serine proteases and is predicted to contain disulphide bonds.


Pssm-ID: 286432  Cd Length: 116  Bit Score: 37.14  E-value: 4.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652  309 WPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFfvtrekilegWKVYAGTSNLHQLPEAASiSQIIINGNYtdEQ----DD 384
Cdd:pfam09342   1 WPWIAKVYLDGNMICSGVLIDASWVIVSGSCL----------RDTNLRHQYISVVLGGAK-TLKSIEGPY--EQivrvDC 67

                          90       100       110
                  ....*....|....*....|....*....|
gi 189011652  385 Y------DIALVRLSKPLTLSAHIHPACLP 408
Cdd:pfam09342  68 RhdipesEISLLHLASPASFSNHVLPTFVP 97
KREPA2 cd23959
Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of ...
 8-69 5.03e-03

Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of the parasitic protozoan's KREPA RNA editing catalytic complex (RECC). Kinetoplastid RNA editing (KRE) proteins occur as pairs or sets of related proteins in multiple complexes. KREPA complex is composed of six components (KREPA1-6), which share a conserved C-terminal region containing an oligonucleotide-binding (OB)-fold-like domain. KREPAs are responsible for the site-specific insertion and deletion of U nucleotides in the kinetoplastid mitochondria pre-messenger RNA. Apart from the conserved C-terminal OB-fold domain, KREPA1, KREPA2, and KREPA3 contain two conserved C2H2 zinc-finger domains. KREPA2 and kinetoplastid RNA editing ligase 1 (KREL1) are specific for ligation post-U-deletion and are paralogous to KREL2 and KREPA1 that are specific for ligation post-U-insertion. KREPA2, is critical for RECC stability and KREL1 integration into the complex.


Pssm-ID: 467780 [Multi-domain]  Cd Length: 424  Bit Score: 39.47  E-value: 5.03e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189011652   8 NASPARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPvraSPARAPP 69
Cdd:cd23959  168 AAAAAQQSSASPGEVASPFASGTVSASPFATATDTAPSSGAPDGFPAEASAP---SPFAAPA 226
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 3-121 5.80e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.77  E-value: 5.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652    3 RGSHRNASPARPSPQASPARASPQASPAR------TPPPQASPARASPPQASPARASPARASPVRASPARAPPSRSSSGR 76
Cdd:PHA03307  274 GWNGPSSRPGPASSSSSPRERSPSPSPSSpgsgpaPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSP 353

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 189011652   77 SSSARSASTTSSPTRvylvraipvGTVIRASPARSAPATRATRES 121
Cdd:PHA03307  354 SRPPPPADPSSPRKR---------PRPSRAPSSPAASAGRPTRRR 389
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 9-127 6.25e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 39.16  E-value: 6.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   9 ASPARPSPQASPARASPQASPART--PPPQAS--PARASPPQASPArASPARASPVRASPARAPPSRSSSGRSSSARSAS 84
Cdd:PTZ00436 230 AKAAAPPAKAAAAPAKAAAAPAKAaaPPAKAAapPAKAAAPPAKAA-APPAKAAAPPAKAAAPPAKAAAAPAKAAAAPAK 308

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 189011652  85 TTSSPTRvylVRAIPVGTVIRASPARSAPATRATRESPGLSFP 127
Cdd:PTZ00436 309 AAAAPAK---AAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAP 348
PRK12495 PRK12495
hypothetical protein; Provisional
 8-120 6.31e-03

hypothetical protein; Provisional


Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 38.31  E-value: 6.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   8 NASPARPSPQASPARASPQASPARTPPPQASPARAS-PPQASPARASP---ARASPVRASPARAPPSRSSSGRSSSARSA 83
Cdd:PRK12495  93 QASPDDDAQPAAEAEAADQSAPPEASSTSATDEAATdPPATAAARDGPtpdPTAQPATPDERRSPRQRPPVSGEPPTPST 172

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 189011652  84 STTSSPTRVYLVRAIPVGTVIRAspARSAPATRATRE 120
Cdd:PRK12495 173 PDAHVAGTLQAARESLVETLARF--ARRAAATDDPRR 207
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 14-127 6.71e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.51  E-value: 6.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011652   14 PSPQASPARASPQASPA--RTPPPQASPARASP--PQASPARASPARASPVRASPARAPPSRSSSGRSSSARSASTTSSP 89
Cdd:pfam05109 455 PTNLTAPASTGPTVSTAdvTSPTPAGTTSGASPvtPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNA 534

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 189011652   90 TRVYLVRAIPVGTVIRASPARSAPATRATRESPGLSFP 127
Cdd:pfam05109 535 TSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIP 572
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 8-67 6.77e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.20  E-value: 6.77e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189011652   8 NASPARPSPQASPARAsPQASPARTPPPQASPARASPPQAS---PARASPARASPVRASPARA 67
Cdd:PRK07764 454 PSPPPAAAPSAQPAPA-PAAAPEPTAAPAPAPPAAPAPAAApaaPAAPAAPAGADDAATLRER 515
PRK14963 PRK14963
DNA polymerase III subunits gamma and tau; Provisional
 11-65 6.98e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184927 [Multi-domain]  Cd Length: 504  Bit Score: 39.05  E-value: 6.98e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 189011652  11 PARPSPQASPARASPQ--ASPARTPPPQASPARASPPqaSPARASPARASPVRASPA 65
Cdd:PRK14963 367 LNRLEKEVRSLRSAPTaaATAAGAPLPDFDPRPRGPP--APEPARSAEAPPLVAPAA 421
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
4-67 7.71e-03

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 38.90  E-value: 7.71e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 189011652    4 GSHRNASPARPSPQASPARASPQ--ASPARTPPPQASPARASPPQA---SPARASPARASPVRASPARA 67
Cdd:pfam03546 240 DSEEEAPAAATPAQAKPALKTPQtkASPRKGTPITPTSAKVPPVRVgtpAPWKAGTVTSPACASSPAVA 308
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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