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Conserved domains on  [gi|189011701|ref|NP_001121041|]
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protein phosphatase 1 regulatory subunit 42 [Rattus norvegicus]

Protein Classification

protein phosphatase 1 regulatory subunit 42( domain architecture ID 15347297)

protein phosphatase 1 regulatory subunit 42 (PPP1R42) regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 27-246 1.85e-100

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


:

Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 295.54  E-value: 1.85e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701  27 LKKITHINFSDRNIDSIDDLSLCKNLSVLYLYDNRISQVTNLNYTTNLTHLYLQNNCISCIENLSSLKKLEKLYLGGNYI 106
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701 107 AVVEGLEGLEELRELHVESQRLPLGEKLLFDPRTLRSLAKSLSTLNISNNNIDDIKDLEMLENLNHLIAVDNQLMHVKDL 186
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDPRSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701 187 EVLLRKLMKLWKMDLNGNPVCLKPKYRDRLILMSKSLEFLDGKEIKNLERQFLMNWKASK 246
Cdd:cd21340  161 LDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQFLKRLKARK 220
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 27-246 1.85e-100

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 295.54  E-value: 1.85e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701  27 LKKITHINFSDRNIDSIDDLSLCKNLSVLYLYDNRISQVTNLNYTTNLTHLYLQNNCISCIENLSSLKKLEKLYLGGNYI 106
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701 107 AVVEGLEGLEELRELHVESQRLPLGEKLLFDPRTLRSLAKSLSTLNISNNNIDDIKDLEMLENLNHLIAVDNQLMHVKDL 186
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDPRSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701 187 EVLLRKLMKLWKMDLNGNPVCLKPKYRDRLILMSKSLEFLDGKEIKNLERQFLMNWKASK 246
Cdd:cd21340  161 LDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQFLKRLKARK 220
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-206 1.36e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 1.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701  27 LKKITHINFSDRNIDSI-DDLSLCKNLSVLYLYDNRISQVTN-LNYTTNLTHLYLQNNCISCI-ENLSSLKKLEKLYLGG 103
Cdd:COG4886  135 LTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSG 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701 104 NYIAVVeglegleelrelhvesqrlplgekllfdPRTLRSLaKSLSTLNISNNNIDDIKDLEMLENLNHLIAVDNQLMHV 183
Cdd:COG4886  215 NQLTDL----------------------------PEPLANL-TNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL 265

                        170       180
                 ....*....|....*....|...
gi 189011701 184 KDLEvllrKLMKLWKMDLNGNPV 206
Cdd:COG4886  266 PPLA----NLTNLKTLDLSNNQL 284
LRR_9 pfam14580
Leucine-rich repeat;
144-254 2.07e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 50.53  E-value: 2.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701  144 LAKSLSTLNISNNNIDDIKD--LEMLENLNHLIAVDNQLMHVKDLEVLLrKLMKLWKMDLNGNPVCLKPKYRDRLILMSK 221
Cdd:pfam14580  62 LLRRLKTLLLNNNRICRIGEglGEALPNLTELILTNNNLQELGDLDPLA-SLKKLTFLSLLRNPVTNKPHYRLYVIYKVP 140

                          90       100       110
                  ....*....|....*....|....*....|...
gi 189011701  222 SLEFLDGKEIKNLERQFLMNWKASKEAKKISKK 254
Cdd:pfam14580 141 QLRLLDFRKVKQKERQAAEKMFRSKQGKQLAKE 173
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 27-246 1.85e-100

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 295.54  E-value: 1.85e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701  27 LKKITHINFSDRNIDSIDDLSLCKNLSVLYLYDNRISQVTNLNYTTNLTHLYLQNNCISCIENLSSLKKLEKLYLGGNYI 106
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701 107 AVVEGLEGLEELRELHVESQRLPLGEKLLFDPRTLRSLAKSLSTLNISNNNIDDIKDLEMLENLNHLIAVDNQLMHVKDL 186
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDPRSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701 187 EVLLRKLMKLWKMDLNGNPVCLKPKYRDRLILMSKSLEFLDGKEIKNLERQFLMNWKASK 246
Cdd:cd21340  161 LDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQFLKRLKARK 220
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-206 1.36e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 1.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701  27 LKKITHINFSDRNIDSI-DDLSLCKNLSVLYLYDNRISQVTN-LNYTTNLTHLYLQNNCISCI-ENLSSLKKLEKLYLGG 103
Cdd:COG4886  135 LTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSG 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701 104 NYIAVVeglegleelrelhvesqrlplgekllfdPRTLRSLaKSLSTLNISNNNIDDIKDLEMLENLNHLIAVDNQLMHV 183
Cdd:COG4886  215 NQLTDL----------------------------PEPLANL-TNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL 265

                        170       180
                 ....*....|....*....|...
gi 189011701 184 KDLEvllrKLMKLWKMDLNGNPV 206
Cdd:COG4886  266 PPLA----NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-206 6.81e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 6.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701  27 LKKITHINFSDRNIDSI-DDLSLCKNLSVLYLYDNRISQV-TNLNYTTNLTHLYLQNNCISCIENLSSLKKLEKLYLGGN 104
Cdd:COG4886  181 LTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNN 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701 105 YIAVVEGLEGLEELRELHVESQRL-PLGEKLLFDPRTLRSLAKSLSTLNISNNNIDDIKDLEMLENLNHLIAVDNQLMHV 183
Cdd:COG4886  261 QLTDLPPLANLTNLKTLDLSNNQLtDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340

                        170       180
                 ....*....|....*....|...
gi 189011701 184 KDLEVLLRKLMKLWKMDLNGNPV 206
Cdd:COG4886  341 ALSLSLLALLTLLLLLNLLSLLL 363
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-196 6.25e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 6.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701  27 LKKITHINFSDRNIDSI-DDLSLCKNLSVLYLYDNRISQVTNLNYTTNLTHLYLQNNCISCIENLSSLKKLEKLYLGGNY 105
Cdd:COG4886  204 LTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQ 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701 106 IAVVE-GLEGLEELRELHVESQRLPLGEKLLFDPRTLRSLAKSLSTLNISNNNIDDIKDLEMLENLNHLIAVDNQLMHVK 184
Cdd:COG4886  284 LTDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLL 363

                        170
                 ....*....|..
gi 189011701 185 DLEVLLRKLMKL 196
Cdd:COG4886  364 TLLLTLGLLGLL 375
LRR_9 pfam14580
Leucine-rich repeat;
144-254 2.07e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 50.53  E-value: 2.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701  144 LAKSLSTLNISNNNIDDIKD--LEMLENLNHLIAVDNQLMHVKDLEVLLrKLMKLWKMDLNGNPVCLKPKYRDRLILMSK 221
Cdd:pfam14580  62 LLRRLKTLLLNNNRICRIGEglGEALPNLTELILTNNNLQELGDLDPLA-SLKKLTFLSLLRNPVTNKPHYRLYVIYKVP 140

                          90       100       110
                  ....*....|....*....|....*....|...
gi 189011701  222 SLEFLDGKEIKNLERQFLMNWKASKEAKKISKK 254
Cdd:pfam14580 141 QLRLLDFRKVKQKERQAAEKMFRSKQGKQLAKE 173
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-206 2.12e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 2.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701  37 DRNIDSIDDLSLCKNLSVLYLYDNRisqvtNLNYTTNLTHLYLQNNCISCI-ENLSSLKKLEKLYLGGNYIAVVeglegl 115
Cdd:COG4886   83 SLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDL------ 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701 116 eelrelhvesqrlplgekllfdPRTLRSLaKSLSTLNISNNNIDDI-KDLEMLENLNHLIAVDNQLmhvKDLEVLLRKLM 194
Cdd:COG4886  152 ----------------------PEPLGNL-TNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQI---TDLPEPLGNLT 205

                        170
                 ....*....|..
gi 189011701 195 KLWKMDLNGNPV 206
Cdd:COG4886  206 NLEELDLSGNQL 217
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 72-104 6.28e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 6.28e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 189011701   72 TNLTHLYLQNNCISCIENLSSLKKLEKLYLGGN 104
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-180 7.35e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.54  E-value: 7.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701  27 LKKITHINFSDRNIDSIDDLSLCKNLSVLYLYDNRISQVTNLNYTTNLTHLYLQNNCISCIeNLSSLKKLEKLYLGGNYI 106
Cdd:COG4886  227 LTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL-KLKELELLLGLNSLLLLL 305

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 189011701 107 AVVEGLEGLEELRELHVESQRLPLGEKLLFDPRTLRSLAKSLSTLNISNNNIDDIKDLEMLENLNHLIAVDNQL 180
Cdd:COG4886  306 LLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATL 379
LRR_9 pfam14580
Leucine-rich repeat;
1-101 7.67e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 42.83  E-value: 7.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701    1 MVRLTVDLIAKN-SNLKPRKE-------------ETLVQCLKKITHINFSDRNIDSIDDLSLCKNLSVLYLYDNRISQVT 66
Cdd:pfam14580   1 MVKLTAELIEQSaQYTNPVREreldlrgykipiiENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 189011701   67 -NLN-YTTNLTHLYLQNNCI---SCIENLSSLKKLEKLYL 101
Cdd:pfam14580  81 eGLGeALPNLTELILTNNNLqelGDLDPLASLKKLTFLSL 120
LRR_8 pfam13855
Leucine rich repeat;
51-106 2.34e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 2.34e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701   51 NLSVLYLYDNRISQV--TNLNYTTNLTHLYLQNNCISCIEN--LSSLKKLEKLYLGGNYI 106
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-206 3.60e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 3.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701  39 NIDSIDDLSLCKNLSVLYLYDNRISQVTNLNYTTNLTHLYLQNNcisciENLSSLKKLEKLYLGGNYIAVVeglegleel 118
Cdd:COG4886   63 SSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDL--------- 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701 119 relhvesqrlplgekllfdPRTLRSLaKSLSTLNISNNNIDDI-KDLEMLENLNHLIAVDNQLmhvKDLEVLLRKLMKLW 197
Cdd:COG4886  129 -------------------PEELANL-TNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQL---TDLPEELGNLTNLK 185


                 ....*....
gi 189011701 198 KMDLNGNPV 206
Cdd:COG4886  186 ELDLSNNQI 194
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 67-206 1.87e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189011701  67 NLNYTTNLTHLYLQNNCISC-----IENLSSLKKLEKLYLGGNYIAVVEGLEGLEELRELHVESQRLPLGEKLLFDpRTL 141
Cdd:cd00116   76 GLTKGCGLQELDLSDNALGPdgcgvLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEG-ASC 154

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 189011701 142 RSLAK------SLSTLNISNNNIDD------IKDLEMLENLNHLIAVDNQLMH--VKDLEVLLRKLMKLWKMDLNGNPV 206
Cdd:cd00116  155 EALAKalranrDLKELNLANNGIGDagiralAEGLKANCNLEVLDLNNNGLTDegASALAETLASLKSLEVLNLGDNNL 233
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 50-92 2.07e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 2.07e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 189011701   50 KNLSVLYLYDNRISQVTNLNYTTNLTHLYL-QNNCISCIENLSS 92
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLsGNNKITDLSDLAN 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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